-- dump date 20140619_082805 -- class Genbank::misc_feature -- table misc_feature_note -- id note 511145000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 511145000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 511145000003 putative catalytic residues [active] 511145000004 putative nucleotide binding site [chemical binding]; other site 511145000005 putative aspartate binding site [chemical binding]; other site 511145000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 511145000007 dimer interface [polypeptide binding]; other site 511145000008 putative threonine allosteric regulatory site; other site 511145000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 511145000010 putative threonine allosteric regulatory site; other site 511145000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 511145000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 511145000013 homoserine kinase; Region: thrB; TIGR00191 511145000014 Protein of unknown function; Region: YhfT; pfam10797 511145000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511145000016 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511145000017 threonine synthase; Validated; Region: PRK09225 511145000018 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 511145000019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145000020 catalytic residue [active] 511145000021 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 511145000022 hypothetical protein; Validated; Region: PRK02101 511145000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 511145000024 transaldolase-like protein; Provisional; Region: PTZ00411 511145000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 511145000026 active site 511145000027 dimer interface [polypeptide binding]; other site 511145000028 catalytic residue [active] 511145000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 511145000030 MPT binding site; other site 511145000031 trimer interface [polypeptide binding]; other site 511145000032 hypothetical protein; Provisional; Region: PRK10659 511145000033 hypothetical protein; Provisional; Region: PRK10236 511145000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 511145000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 511145000036 hypothetical protein; Provisional; Region: PRK10154 511145000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 511145000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 511145000039 nucleotide binding site [chemical binding]; other site 511145000040 NEF interaction site [polypeptide binding]; other site 511145000041 SBD interface [polypeptide binding]; other site 511145000042 chaperone protein DnaJ; Provisional; Region: PRK10767 511145000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511145000044 HSP70 interaction site [polypeptide binding]; other site 511145000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 511145000046 substrate binding site [polypeptide binding]; other site 511145000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 511145000048 Zn binding sites [ion binding]; other site 511145000049 dimer interface [polypeptide binding]; other site 511145000050 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 511145000051 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511145000052 Hok/gef family; Region: HOK_GEF; pfam01848 511145000053 Hok/gef family; Region: HOK_GEF; pfam01848 511145000054 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 511145000055 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 511145000056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145000057 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 511145000058 putative dimerization interface [polypeptide binding]; other site 511145000059 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 511145000060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 511145000061 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 511145000062 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 511145000063 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 511145000064 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 511145000065 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 511145000066 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 511145000067 active site 511145000068 Riboflavin kinase; Region: Flavokinase; smart00904 511145000069 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 511145000070 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 511145000071 active site 511145000072 HIGH motif; other site 511145000073 KMSKS motif; other site 511145000074 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 511145000075 tRNA binding surface [nucleotide binding]; other site 511145000076 anticodon binding site; other site 511145000077 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511145000078 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 511145000079 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 511145000080 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 511145000081 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 511145000082 Fe-S cluster binding site [ion binding]; other site 511145000083 substrate binding site [chemical binding]; other site 511145000084 catalytic site [active] 511145000085 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 511145000086 active site 511145000087 tetramer interface [polypeptide binding]; other site 511145000088 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 511145000089 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 511145000090 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 511145000091 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 511145000092 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 511145000093 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 511145000094 catalytic site [active] 511145000095 subunit interface [polypeptide binding]; other site 511145000096 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 511145000097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511145000098 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 511145000099 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 511145000100 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511145000101 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511145000102 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 511145000103 IMP binding site; other site 511145000104 dimer interface [polypeptide binding]; other site 511145000105 interdomain contacts; other site 511145000106 partial ornithine binding site; other site 511145000107 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 511145000108 carnitine operon protein CaiE; Provisional; Region: PRK13627 511145000109 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 511145000110 putative trimer interface [polypeptide binding]; other site 511145000111 putative metal binding site [ion binding]; other site 511145000112 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 511145000113 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511145000114 substrate binding site [chemical binding]; other site 511145000115 oxyanion hole (OAH) forming residues; other site 511145000116 trimer interface [polypeptide binding]; other site 511145000117 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 511145000118 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 511145000119 acyl-activating enzyme (AAE) consensus motif; other site 511145000120 putative AMP binding site [chemical binding]; other site 511145000121 putative active site [active] 511145000122 putative CoA binding site [chemical binding]; other site 511145000123 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 511145000124 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 511145000125 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 511145000126 active site 511145000127 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 511145000128 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 511145000129 Ligand binding site [chemical binding]; other site 511145000130 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 511145000131 Electron transfer flavoprotein domain; Region: ETF; pfam01012 511145000132 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 511145000133 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145000134 putative oxidoreductase FixC; Provisional; Region: PRK10157 511145000135 ferredoxin-like protein FixX; Provisional; Region: PRK15449 511145000136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145000137 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 511145000138 putative substrate translocation pore; other site 511145000139 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 511145000140 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 511145000141 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 511145000142 TrkA-N domain; Region: TrkA_N; pfam02254 511145000143 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 511145000144 folate binding site [chemical binding]; other site 511145000145 NADP+ binding site [chemical binding]; other site 511145000146 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 511145000147 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 511145000148 active site 511145000149 metal binding site [ion binding]; metal-binding site 511145000150 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 511145000151 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 511145000152 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 511145000153 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 511145000154 SurA N-terminal domain; Region: SurA_N; pfam09312 511145000155 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 511145000156 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 511145000157 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 511145000158 OstA-like protein; Region: OstA; pfam03968 511145000159 Organic solvent tolerance protein; Region: OstA_C; pfam04453 511145000160 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 511145000161 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 511145000162 putative metal binding site [ion binding]; other site 511145000163 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511145000164 HSP70 interaction site [polypeptide binding]; other site 511145000165 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511145000166 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511145000167 active site 511145000168 ATP-dependent helicase HepA; Validated; Region: PRK04914 511145000169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145000170 ATP binding site [chemical binding]; other site 511145000171 putative Mg++ binding site [ion binding]; other site 511145000172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145000173 nucleotide binding region [chemical binding]; other site 511145000174 ATP-binding site [chemical binding]; other site 511145000175 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 511145000176 DNA polymerase II; Reviewed; Region: PRK05762 511145000177 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 511145000178 active site 511145000179 catalytic site [active] 511145000180 substrate binding site [chemical binding]; other site 511145000181 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 511145000182 active site 511145000183 metal-binding site 511145000184 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 511145000185 intersubunit interface [polypeptide binding]; other site 511145000186 active site 511145000187 Zn2+ binding site [ion binding]; other site 511145000188 L-arabinose isomerase; Provisional; Region: PRK02929 511145000189 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 511145000190 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 511145000191 trimer interface [polypeptide binding]; other site 511145000192 putative substrate binding site [chemical binding]; other site 511145000193 putative metal binding site [ion binding]; other site 511145000194 ribulokinase; Provisional; Region: PRK04123 511145000195 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 511145000196 N- and C-terminal domain interface [polypeptide binding]; other site 511145000197 active site 511145000198 MgATP binding site [chemical binding]; other site 511145000199 catalytic site [active] 511145000200 metal binding site [ion binding]; metal-binding site 511145000201 carbohydrate binding site [chemical binding]; other site 511145000202 homodimer interface [polypeptide binding]; other site 511145000203 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 511145000204 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511145000205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145000206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145000207 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 511145000208 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 511145000209 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 511145000210 Walker A/P-loop; other site 511145000211 ATP binding site [chemical binding]; other site 511145000212 Q-loop/lid; other site 511145000213 ABC transporter signature motif; other site 511145000214 Walker B; other site 511145000215 D-loop; other site 511145000216 H-loop/switch region; other site 511145000217 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 511145000218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145000219 dimer interface [polypeptide binding]; other site 511145000220 conserved gate region; other site 511145000221 putative PBP binding loops; other site 511145000222 ABC-ATPase subunit interface; other site 511145000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145000224 dimer interface [polypeptide binding]; other site 511145000225 conserved gate region; other site 511145000226 putative PBP binding loops; other site 511145000227 ABC-ATPase subunit interface; other site 511145000228 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 511145000229 transcriptional regulator SgrR; Provisional; Region: PRK13626 511145000230 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 511145000231 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 511145000232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145000233 sugar efflux transporter; Region: 2A0120; TIGR00899 511145000234 putative substrate translocation pore; other site 511145000235 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 511145000236 substrate binding site [chemical binding]; other site 511145000237 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 511145000238 substrate binding site [chemical binding]; other site 511145000239 ligand binding site [chemical binding]; other site 511145000240 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 511145000241 2-isopropylmalate synthase; Validated; Region: PRK00915 511145000242 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 511145000243 active site 511145000244 catalytic residues [active] 511145000245 metal binding site [ion binding]; metal-binding site 511145000246 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 511145000247 leu operon leader peptide; Provisional; Region: PRK09925 511145000248 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 511145000249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145000250 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 511145000251 putative substrate binding pocket [chemical binding]; other site 511145000252 putative dimerization interface [polypeptide binding]; other site 511145000253 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 511145000254 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 511145000255 PYR/PP interface [polypeptide binding]; other site 511145000256 dimer interface [polypeptide binding]; other site 511145000257 TPP binding site [chemical binding]; other site 511145000258 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511145000259 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 511145000260 TPP-binding site [chemical binding]; other site 511145000261 dimer interface [polypeptide binding]; other site 511145000262 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 511145000263 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 511145000264 putative valine binding site [chemical binding]; other site 511145000265 dimer interface [polypeptide binding]; other site 511145000266 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 511145000267 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 511145000268 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145000269 DNA binding site [nucleotide binding] 511145000270 domain linker motif; other site 511145000271 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 511145000272 dimerization interface [polypeptide binding]; other site 511145000273 ligand binding site [chemical binding]; other site 511145000274 mraZ protein; Region: TIGR00242 511145000275 MraZ protein; Region: MraZ; pfam02381 511145000276 MraZ protein; Region: MraZ; pfam02381 511145000277 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 511145000278 cell division protein FtsL; Provisional; Region: PRK10772 511145000279 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 511145000280 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 511145000281 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511145000282 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 511145000283 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511145000284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511145000285 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511145000286 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 511145000287 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511145000288 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511145000289 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511145000290 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 511145000291 Mg++ binding site [ion binding]; other site 511145000292 putative catalytic motif [active] 511145000293 putative substrate binding site [chemical binding]; other site 511145000294 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 511145000295 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511145000296 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511145000297 cell division protein FtsW; Provisional; Region: PRK10774 511145000298 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 511145000299 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 511145000300 active site 511145000301 homodimer interface [polypeptide binding]; other site 511145000302 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 511145000303 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511145000304 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511145000305 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511145000306 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 511145000307 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 511145000308 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 511145000309 cell division protein FtsQ; Provisional; Region: PRK10775 511145000310 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 511145000311 Cell division protein FtsQ; Region: FtsQ; pfam03799 511145000312 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 511145000313 Cell division protein FtsA; Region: FtsA; pfam14450 511145000314 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145000315 Cell division protein FtsA; Region: FtsA; pfam14450 511145000316 cell division protein FtsZ; Validated; Region: PRK09330 511145000317 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 511145000318 nucleotide binding site [chemical binding]; other site 511145000319 SulA interaction site; other site 511145000320 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 511145000321 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 511145000322 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 511145000323 SecA regulator SecM; Provisional; Region: PRK02943 511145000324 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 511145000325 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 511145000326 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 511145000327 SEC-C motif; Region: SEC-C; pfam02810 511145000328 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 511145000329 active site 511145000330 8-oxo-dGMP binding site [chemical binding]; other site 511145000331 nudix motif; other site 511145000332 metal binding site [ion binding]; metal-binding site 511145000333 DNA gyrase inhibitor; Reviewed; Region: PRK00418 511145000334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 511145000335 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 511145000336 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 511145000337 CoA-binding site [chemical binding]; other site 511145000338 ATP-binding [chemical binding]; other site 511145000339 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 511145000340 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 511145000341 active site 511145000342 type IV pilin biogenesis protein; Provisional; Region: PRK10573 511145000343 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511145000344 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511145000345 hypothetical protein; Provisional; Region: PRK10436 511145000346 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 511145000347 Walker A motif; other site 511145000348 ATP binding site [chemical binding]; other site 511145000349 Walker B motif; other site 511145000350 putative major pilin subunit; Provisional; Region: PRK10574 511145000351 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 511145000352 Pilin (bacterial filament); Region: Pilin; pfam00114 511145000353 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 511145000354 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 511145000355 dimerization interface [polypeptide binding]; other site 511145000356 active site 511145000357 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 511145000358 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511145000359 amidase catalytic site [active] 511145000360 Zn binding residues [ion binding]; other site 511145000361 substrate binding site [chemical binding]; other site 511145000362 regulatory protein AmpE; Provisional; Region: PRK10987 511145000363 aromatic amino acid transporter; Provisional; Region: PRK10238 511145000364 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145000365 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 511145000366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145000367 DNA-binding site [nucleotide binding]; DNA binding site 511145000368 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 511145000369 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 511145000370 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 511145000371 dimer interface [polypeptide binding]; other site 511145000372 TPP-binding site [chemical binding]; other site 511145000373 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 511145000374 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511145000375 E3 interaction surface; other site 511145000376 lipoyl attachment site [posttranslational modification]; other site 511145000377 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511145000378 E3 interaction surface; other site 511145000379 lipoyl attachment site [posttranslational modification]; other site 511145000380 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511145000381 E3 interaction surface; other site 511145000382 lipoyl attachment site [posttranslational modification]; other site 511145000383 e3 binding domain; Region: E3_binding; pfam02817 511145000384 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 511145000385 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 511145000386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145000387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145000388 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 511145000389 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 511145000390 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 511145000391 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 511145000392 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 511145000393 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 511145000394 substrate binding site [chemical binding]; other site 511145000395 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 511145000396 substrate binding site [chemical binding]; other site 511145000397 ligand binding site [chemical binding]; other site 511145000398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112 511145000399 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 511145000400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145000401 S-adenosylmethionine binding site [chemical binding]; other site 511145000402 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 511145000403 multicopper oxidase; Provisional; Region: PRK10965 511145000404 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 511145000405 Domain 2 interface [polypeptide binding]; other site 511145000406 Domain 3 interface [polypeptide binding]; other site 511145000407 trinuclear Cu binding site [ion binding]; other site 511145000408 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 511145000409 Domain 1 interface [polypeptide binding]; other site 511145000410 Domain 3 interface [polypeptide binding]; other site 511145000411 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 511145000412 Domain 2 interface [polypeptide binding]; other site 511145000413 Domain 1 interface [polypeptide binding]; other site 511145000414 Type 1 (T1) Cu binding site [ion binding]; other site 511145000415 trinuclear Cu binding site [ion binding]; other site 511145000416 Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993 511145000417 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 511145000418 Trp docking motif [polypeptide binding]; other site 511145000419 putative active site [active] 511145000420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511145000421 active site 511145000422 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 511145000423 active site clefts [active] 511145000424 zinc binding site [ion binding]; other site 511145000425 dimer interface [polypeptide binding]; other site 511145000426 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511145000427 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511145000428 Walker A/P-loop; other site 511145000429 ATP binding site [chemical binding]; other site 511145000430 Q-loop/lid; other site 511145000431 ABC transporter signature motif; other site 511145000432 Walker B; other site 511145000433 D-loop; other site 511145000434 H-loop/switch region; other site 511145000435 inner membrane transport permease; Provisional; Region: PRK15066 511145000436 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 511145000437 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 511145000438 active pocket/dimerization site; other site 511145000439 active site 511145000440 phosphorylation site [posttranslational modification] 511145000441 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 511145000442 putative active site [active] 511145000443 putative metal binding site [ion binding]; other site 511145000444 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 511145000445 tetramerization interface [polypeptide binding]; other site 511145000446 active site 511145000447 Uncharacterized conserved protein [Function unknown]; Region: COG5464 511145000448 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 511145000449 Pantoate-beta-alanine ligase; Region: PanC; cd00560 511145000450 active site 511145000451 ATP-binding site [chemical binding]; other site 511145000452 pantoate-binding site; other site 511145000453 HXXH motif; other site 511145000454 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 511145000455 oligomerization interface [polypeptide binding]; other site 511145000456 active site 511145000457 metal binding site [ion binding]; metal-binding site 511145000458 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 511145000459 putative fimbrial protein StaF; Provisional; Region: PRK15262 511145000460 putative fimbrial protein StaE; Provisional; Region: PRK15263 511145000461 Fimbrial protein; Region: Fimbrial; cl01416 511145000462 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 511145000463 PapC N-terminal domain; Region: PapC_N; pfam13954 511145000464 Outer membrane usher protein; Region: Usher; pfam00577 511145000465 PapC C-terminal domain; Region: PapC_C; pfam13953 511145000466 putative chaperone protein EcpD; Provisional; Region: PRK09926 511145000467 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145000468 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145000469 Fimbrial protein; Region: Fimbrial; cl01416 511145000470 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 511145000471 catalytic center binding site [active] 511145000472 ATP binding site [chemical binding]; other site 511145000473 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 511145000474 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 511145000475 active site 511145000476 NTP binding site [chemical binding]; other site 511145000477 metal binding triad [ion binding]; metal-binding site 511145000478 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 511145000479 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 511145000480 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 511145000481 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 511145000482 active site 511145000483 nucleotide binding site [chemical binding]; other site 511145000484 HIGH motif; other site 511145000485 KMSKS motif; other site 511145000486 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 511145000487 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 511145000488 2'-5' RNA ligase; Provisional; Region: PRK15124 511145000489 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 511145000490 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 511145000491 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 511145000492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145000493 ATP binding site [chemical binding]; other site 511145000494 putative Mg++ binding site [ion binding]; other site 511145000495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145000496 nucleotide binding region [chemical binding]; other site 511145000497 ATP-binding site [chemical binding]; other site 511145000498 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 511145000499 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 511145000500 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 511145000501 Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812 511145000502 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 511145000503 Transglycosylase; Region: Transgly; pfam00912 511145000504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 511145000505 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 511145000506 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 511145000507 N-terminal plug; other site 511145000508 ligand-binding site [chemical binding]; other site 511145000509 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 511145000510 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511145000511 Walker A/P-loop; other site 511145000512 ATP binding site [chemical binding]; other site 511145000513 Q-loop/lid; other site 511145000514 ABC transporter signature motif; other site 511145000515 Walker B; other site 511145000516 D-loop; other site 511145000517 H-loop/switch region; other site 511145000518 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 511145000519 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 511145000520 siderophore binding site; other site 511145000521 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 511145000522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511145000523 ABC-ATPase subunit interface; other site 511145000524 dimer interface [polypeptide binding]; other site 511145000525 putative PBP binding regions; other site 511145000526 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511145000527 ABC-ATPase subunit interface; other site 511145000528 dimer interface [polypeptide binding]; other site 511145000529 putative PBP binding regions; other site 511145000530 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 511145000531 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511145000532 inhibitor-cofactor binding pocket; inhibition site 511145000533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145000534 catalytic residue [active] 511145000535 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 511145000536 Cl- selectivity filter; other site 511145000537 Cl- binding residues [ion binding]; other site 511145000538 pore gating glutamate residue; other site 511145000539 dimer interface [polypeptide binding]; other site 511145000540 H+/Cl- coupling transport residue; other site 511145000541 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 511145000542 hypothetical protein; Provisional; Region: PRK10578 511145000543 UPF0126 domain; Region: UPF0126; pfam03458 511145000544 UPF0126 domain; Region: UPF0126; pfam03458 511145000545 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 511145000546 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 511145000547 cobalamin binding residues [chemical binding]; other site 511145000548 putative BtuC binding residues; other site 511145000549 dimer interface [polypeptide binding]; other site 511145000550 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 511145000551 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 511145000552 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511145000553 Zn2+ binding site [ion binding]; other site 511145000554 Mg2+ binding site [ion binding]; other site 511145000555 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 511145000556 serine endoprotease; Provisional; Region: PRK10942 511145000557 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 511145000558 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511145000559 protein binding site [polypeptide binding]; other site 511145000560 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511145000561 protein binding site [polypeptide binding]; other site 511145000562 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 511145000563 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 511145000564 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 511145000565 hypothetical protein; Provisional; Region: PRK13677 511145000566 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 511145000567 putative active site [active] 511145000568 putative metal binding site [ion binding]; other site 511145000569 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 511145000570 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 511145000571 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 511145000572 trimer interface [polypeptide binding]; other site 511145000573 active site 511145000574 substrate binding site [chemical binding]; other site 511145000575 CoA binding site [chemical binding]; other site 511145000576 PII uridylyl-transferase; Provisional; Region: PRK05007 511145000577 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 511145000578 metal binding triad; other site 511145000579 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 511145000580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511145000581 Zn2+ binding site [ion binding]; other site 511145000582 Mg2+ binding site [ion binding]; other site 511145000583 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 511145000584 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 511145000585 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 511145000586 active site 511145000587 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 511145000588 rRNA interaction site [nucleotide binding]; other site 511145000589 S8 interaction site; other site 511145000590 putative laminin-1 binding site; other site 511145000591 elongation factor Ts; Provisional; Region: tsf; PRK09377 511145000592 UBA/TS-N domain; Region: UBA; pfam00627 511145000593 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 511145000594 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 511145000595 putative nucleotide binding site [chemical binding]; other site 511145000596 uridine monophosphate binding site [chemical binding]; other site 511145000597 homohexameric interface [polypeptide binding]; other site 511145000598 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 511145000599 hinge region; other site 511145000600 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: Dxr; TIGR00243 511145000601 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 511145000602 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 511145000603 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 511145000604 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 511145000605 active site 511145000606 dimer interface [polypeptide binding]; other site 511145000607 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 511145000608 zinc metallopeptidase RseP; Provisional; Region: PRK10779 511145000609 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 511145000610 active site 511145000611 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 511145000612 protein binding site [polypeptide binding]; other site 511145000613 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 511145000614 protein binding site [polypeptide binding]; other site 511145000615 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511145000616 putative substrate binding region [chemical binding]; other site 511145000617 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 511145000618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 511145000619 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 511145000620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 511145000621 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 511145000622 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 511145000623 Surface antigen; Region: Bac_surface_Ag; pfam01103 511145000624 periplasmic chaperone; Provisional; Region: PRK10780 511145000625 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 511145000626 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 511145000627 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 511145000628 trimer interface [polypeptide binding]; other site 511145000629 active site 511145000630 UDP-GlcNAc binding site [chemical binding]; other site 511145000631 lipid binding site [chemical binding]; lipid-binding site 511145000632 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511145000633 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 511145000634 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 511145000635 active site 511145000636 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 511145000637 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 511145000638 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 511145000639 RNA/DNA hybrid binding site [nucleotide binding]; other site 511145000640 active site 511145000641 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 511145000642 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 511145000643 putative active site [active] 511145000644 putative PHP Thumb interface [polypeptide binding]; other site 511145000645 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 511145000646 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 511145000647 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 511145000648 generic binding surface II; other site 511145000649 generic binding surface I; other site 511145000650 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 511145000651 lysine decarboxylase LdcC; Provisional; Region: PRK15399 511145000652 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 511145000653 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 511145000654 homodimer interface [polypeptide binding]; other site 511145000655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145000656 catalytic residue [active] 511145000657 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 511145000658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 511145000659 putative metal binding site [ion binding]; other site 511145000660 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 511145000661 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 511145000662 Ligand Binding Site [chemical binding]; other site 511145000663 TilS substrate binding domain; Region: TilS; pfam09179 511145000664 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 511145000665 Rho-binding antiterminator; Provisional; Region: PRK11625 511145000666 hypothetical protein; Provisional; Region: PRK04964 511145000667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 511145000668 hypothetical protein; Provisional; Region: PRK09256 511145000669 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 511145000670 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 511145000671 Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015 511145000672 hypothetical protein; Provisional; Region: PRK11479 511145000673 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511145000674 prolyl-tRNA synthetase; Provisional; Region: PRK09194 511145000675 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 511145000676 dimer interface [polypeptide binding]; other site 511145000677 motif 1; other site 511145000678 active site 511145000679 motif 2; other site 511145000680 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 511145000681 putative deacylase active site [active] 511145000682 motif 3; other site 511145000683 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 511145000684 anticodon binding site; other site 511145000685 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 511145000686 homodimer interaction site [polypeptide binding]; other site 511145000687 cofactor binding site; other site 511145000688 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 511145000689 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 511145000690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145000691 dimer interface [polypeptide binding]; other site 511145000692 conserved gate region; other site 511145000693 putative PBP binding loops; other site 511145000694 ABC-ATPase subunit interface; other site 511145000695 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 511145000696 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 511145000697 Walker A/P-loop; other site 511145000698 ATP binding site [chemical binding]; other site 511145000699 Q-loop/lid; other site 511145000700 ABC transporter signature motif; other site 511145000701 Walker B; other site 511145000702 D-loop; other site 511145000703 H-loop/switch region; other site 511145000704 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 511145000705 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 511145000706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145000707 active site 511145000708 motif I; other site 511145000709 motif II; other site 511145000710 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511145000711 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 511145000712 active site 511145000713 catalytic tetrad [active] 511145000714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145000715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145000716 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 511145000717 putative effector binding pocket; other site 511145000718 dimerization interface [polypeptide binding]; other site 511145000719 hypothetical protein; Provisional; Region: PRK05421 511145000720 putative catalytic site [active] 511145000721 putative metal binding site [ion binding]; other site 511145000722 putative phosphate binding site [ion binding]; other site 511145000723 putative catalytic site [active] 511145000724 putative phosphate binding site [ion binding]; other site 511145000725 putative metal binding site [ion binding]; other site 511145000726 Methyltransferase domain; Region: Methyltransf_31; pfam13847 511145000727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145000728 S-adenosylmethionine binding site [chemical binding]; other site 511145000729 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 511145000730 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 511145000731 N-acetyl-D-glucosamine binding site [chemical binding]; other site 511145000732 catalytic residue [active] 511145000733 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511145000734 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511145000735 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 511145000736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145000737 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 511145000738 RNA/DNA hybrid binding site [nucleotide binding]; other site 511145000739 active site 511145000740 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 511145000741 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 511145000742 active site 511145000743 catalytic site [active] 511145000744 substrate binding site [chemical binding]; other site 511145000745 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 511145000746 putative active site [active] 511145000747 catalytic triad [active] 511145000748 dimer interface [polypeptide binding]; other site 511145000749 multimer interface [polypeptide binding]; other site 511145000750 C-lysozyme inhibitor; Provisional; Region: PRK09993 511145000751 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 511145000752 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 511145000753 active site 511145000754 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 511145000755 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 511145000756 dimer interface [polypeptide binding]; other site 511145000757 active site 511145000758 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 511145000759 putative active site [active] 511145000760 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 511145000761 putative dimer interface [polypeptide binding]; other site 511145000762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 511145000763 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 511145000764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 511145000765 RelB antitoxin; Region: RelB; pfam04221 511145000766 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511145000767 NlpC/P60 family; Region: NLPC_P60; pfam00877 511145000768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 511145000769 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 511145000770 active site 511145000771 DNA polymerase IV; Validated; Region: PRK02406 511145000772 DNA binding site [nucleotide binding] 511145000773 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 511145000774 putative toxin YafO; Provisional; Region: PRK09885 511145000775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511145000776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145000777 Coenzyme A binding pocket [chemical binding]; other site 511145000778 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 511145000779 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 511145000780 metal binding site [ion binding]; metal-binding site 511145000781 dimer interface [polypeptide binding]; other site 511145000782 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511145000783 active site 511145000784 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 511145000785 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 511145000786 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 511145000787 trimer interface [polypeptide binding]; other site 511145000788 eyelet of channel; other site 511145000789 gamma-glutamyl kinase; Provisional; Region: PRK05429 511145000790 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 511145000791 nucleotide binding site [chemical binding]; other site 511145000792 homotetrameric interface [polypeptide binding]; other site 511145000793 putative phosphate binding site [ion binding]; other site 511145000794 putative allosteric binding site; other site 511145000795 PUA domain; Region: PUA; pfam01472 511145000796 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 511145000797 putative catalytic cysteine [active] 511145000798 cryptic prophage CP4-6 511145000799 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 511145000800 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 511145000801 Protein of unknown function (DUF987); Region: DUF987; pfam06174 511145000802 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 511145000803 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 511145000804 MPN+ (JAMM) motif; other site 511145000805 Zinc-binding site [ion binding]; other site 511145000806 Antirestriction protein; Region: Antirestrict; pfam03230 511145000807 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 511145000808 Predicted transcriptional regulator [Transcription]; Region: COG2378 511145000809 Domain of unknown function (DUF932); Region: DUF932; pfam06067 511145000810 Predicted GTPase [General function prediction only]; Region: COG3596 511145000811 YfjP GTPase; Region: YfjP; cd11383 511145000812 G1 box; other site 511145000813 GTP/Mg2+ binding site [chemical binding]; other site 511145000814 Switch I region; other site 511145000815 G2 box; other site 511145000816 Switch II region; other site 511145000817 G3 box; other site 511145000818 G4 box; other site 511145000819 G5 box; other site 511145000820 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 511145000821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145000822 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 511145000823 dimerization interface [polypeptide binding]; other site 511145000824 substrate binding pocket [chemical binding]; other site 511145000825 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511145000826 Helix-turn-helix domain; Region: HTH_38; pfam13936 511145000827 Homeodomain-like domain; Region: HTH_32; pfam13565 511145000828 Integrase core domain; Region: rve; pfam00665 511145000829 Transposase domain (DUF772); Region: DUF772; pfam05598 511145000830 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145000831 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145000832 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145000833 S-methylmethionine transporter; Provisional; Region: PRK11387 511145000834 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145000835 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 511145000836 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 511145000837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145000838 Walker A/P-loop; other site 511145000839 ATP binding site [chemical binding]; other site 511145000840 Q-loop/lid; other site 511145000841 ABC transporter signature motif; other site 511145000842 Walker B; other site 511145000843 D-loop; other site 511145000844 H-loop/switch region; other site 511145000845 TOBE domain; Region: TOBE_2; pfam08402 511145000846 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 511145000847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 511145000848 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 511145000849 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 511145000850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145000851 Helix-turn-helix domain; Region: HTH_28; pfam13518 511145000852 Homeodomain-like domain; Region: HTH_32; pfam13565 511145000853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 511145000854 Integrase core domain; Region: rve; pfam00665 511145000855 Integrase core domain; Region: rve_3; pfam13683 511145000856 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 511145000857 inhibitor site; inhibition site 511145000858 active site 511145000859 dimer interface [polypeptide binding]; other site 511145000860 catalytic residue [active] 511145000861 putative dehydratase; Provisional; Region: PRK08211 511145000862 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511145000863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145000864 putative substrate translocation pore; other site 511145000865 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 511145000866 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 511145000867 inhibitor binding site; inhibition site 511145000868 active site 511145000869 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 511145000870 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 511145000871 Transcriptional regulator [Transcription]; Region: IclR; COG1414 511145000872 Bacterial transcriptional regulator; Region: IclR; pfam01614 511145000873 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 511145000874 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511145000875 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511145000876 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 511145000877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 511145000878 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 511145000879 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 511145000880 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 511145000881 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 511145000882 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 511145000883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511145000884 active site 511145000885 DNA binding site [nucleotide binding] 511145000886 Int/Topo IB signature motif; other site 511145000887 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 511145000888 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 511145000889 XdhC Rossmann domain; Region: XdhC_C; pfam13478 511145000890 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 511145000891 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 511145000892 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 511145000893 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 511145000894 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 511145000895 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 511145000896 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 511145000897 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511145000898 catalytic loop [active] 511145000899 iron binding site [ion binding]; other site 511145000900 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 511145000901 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 511145000902 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 511145000903 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 511145000904 Outer membrane usher protein; Region: Usher; pfam00577 511145000905 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 511145000906 putative fimbrial protein TcfA; Provisional; Region: PRK15308 511145000907 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 511145000908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145000909 DNA binding residues [nucleotide binding] 511145000910 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 511145000911 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 511145000912 Transposase; Region: HTH_Tnp_1; cl17663 511145000913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145000914 putative transposase OrfB; Reviewed; Region: PHA02517 511145000915 HTH-like domain; Region: HTH_21; pfam13276 511145000916 Integrase core domain; Region: rve; pfam00665 511145000917 Integrase core domain; Region: rve_2; pfam13333 511145000918 Predicted membrane protein [Function unknown]; Region: COG3059 511145000919 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 511145000920 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 511145000921 Squalene epoxidase; Region: SE; cl17314 511145000922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145000923 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 511145000924 Cupin; Region: Cupin_6; pfam12852 511145000925 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 511145000926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145000927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145000928 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 511145000929 Cysteine-rich domain; Region: CCG; pfam02754 511145000930 Cysteine-rich domain; Region: CCG; pfam02754 511145000931 iron-sulfur cluster-binding protein; Region: TIGR00273 511145000932 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 511145000933 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 511145000934 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 511145000935 Uncharacterized conserved protein [Function unknown]; Region: COG1556 511145000936 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 511145000937 choline dehydrogenase; Validated; Region: PRK02106 511145000938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145000939 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 511145000940 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 511145000941 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 511145000942 tetrameric interface [polypeptide binding]; other site 511145000943 NAD binding site [chemical binding]; other site 511145000944 catalytic residues [active] 511145000945 transcriptional regulator BetI; Validated; Region: PRK00767 511145000946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145000947 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 511145000948 choline transport protein BetT; Provisional; Region: PRK09928 511145000949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145000950 DNA binding residues [nucleotide binding] 511145000951 dimerization interface [polypeptide binding]; other site 511145000952 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145000953 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 511145000954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145000955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145000956 dimerization interface [polypeptide binding]; other site 511145000957 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 511145000958 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 511145000959 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 511145000960 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 511145000961 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 511145000962 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 511145000963 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 511145000964 CoA binding domain; Region: CoA_binding; pfam02629 511145000965 CoA-ligase; Region: Ligase_CoA; pfam00549 511145000966 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 511145000967 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 511145000968 putative substrate binding site [chemical binding]; other site 511145000969 nucleotide binding site [chemical binding]; other site 511145000970 nucleotide binding site [chemical binding]; other site 511145000971 homodimer interface [polypeptide binding]; other site 511145000972 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 511145000973 cytosine deaminase; Provisional; Region: PRK05985 511145000974 active site 511145000975 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 511145000976 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 511145000977 putative NAD(P) binding site [chemical binding]; other site 511145000978 putative substrate binding site [chemical binding]; other site 511145000979 catalytic Zn binding site [ion binding]; other site 511145000980 structural Zn binding site [ion binding]; other site 511145000981 dimer interface [polypeptide binding]; other site 511145000982 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 511145000983 hypothetical protein; Provisional; Region: PRK09929 511145000984 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 511145000985 Propionate catabolism activator; Region: PrpR_N; pfam06506 511145000986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145000987 Walker A motif; other site 511145000988 ATP binding site [chemical binding]; other site 511145000989 Walker B motif; other site 511145000990 arginine finger; other site 511145000991 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511145000992 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 511145000993 tetramer interface [polypeptide binding]; other site 511145000994 active site 511145000995 Mg2+/Mn2+ binding site [ion binding]; other site 511145000996 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 511145000997 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 511145000998 dimer interface [polypeptide binding]; other site 511145000999 active site 511145001000 citrylCoA binding site [chemical binding]; other site 511145001001 oxalacetate/citrate binding site [chemical binding]; other site 511145001002 coenzyme A binding site [chemical binding]; other site 511145001003 catalytic triad [active] 511145001004 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 511145001005 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 511145001006 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 511145001007 acyl-activating enzyme (AAE) consensus motif; other site 511145001008 putative AMP binding site [chemical binding]; other site 511145001009 putative active site [active] 511145001010 putative CoA binding site [chemical binding]; other site 511145001011 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 511145001012 Na binding site [ion binding]; other site 511145001013 putative substrate binding site [chemical binding]; other site 511145001014 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 511145001015 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 511145001016 active site 511145001017 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 511145001018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145001019 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 511145001020 dimerization interface [polypeptide binding]; other site 511145001021 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 511145001022 active site clefts [active] 511145001023 zinc binding site [ion binding]; other site 511145001024 dimer interface [polypeptide binding]; other site 511145001025 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 511145001026 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 511145001027 oligomer interface [polypeptide binding]; other site 511145001028 active site 511145001029 putative cyanate transporter; Provisional; Region: cynX; PRK09705 511145001030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145001031 putative substrate translocation pore; other site 511145001032 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 511145001033 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511145001034 active site 511145001035 substrate binding site [chemical binding]; other site 511145001036 trimer interface [polypeptide binding]; other site 511145001037 CoA binding site [chemical binding]; other site 511145001038 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 511145001039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145001040 putative substrate translocation pore; other site 511145001041 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 511145001042 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 511145001043 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 511145001044 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 511145001045 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 511145001046 lac repressor; Reviewed; Region: lacI; PRK09526 511145001047 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145001048 DNA binding site [nucleotide binding] 511145001049 domain linker motif; other site 511145001050 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 511145001051 ligand binding site [chemical binding]; other site 511145001052 dimerization interface (open form) [polypeptide binding]; other site 511145001053 dimerization interface (closed form) [polypeptide binding]; other site 511145001054 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 511145001055 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 511145001056 Bacterial transcriptional regulator; Region: IclR; pfam01614 511145001057 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 511145001058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145001059 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 511145001060 putative active site [active] 511145001061 Fe(II) binding site [ion binding]; other site 511145001062 putative dimer interface [polypeptide binding]; other site 511145001063 putative tetramer interface [polypeptide binding]; other site 511145001064 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 511145001065 Putative lysophospholipase; Region: Hydrolase_4; cl19140 511145001066 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 511145001067 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 511145001068 acetaldehyde dehydrogenase; Validated; Region: PRK08300 511145001069 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 511145001070 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 511145001071 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 511145001072 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 511145001073 active site 511145001074 catalytic residues [active] 511145001075 metal binding site [ion binding]; metal-binding site 511145001076 DmpG-like communication domain; Region: DmpG_comm; pfam07836 511145001077 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 511145001078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145001079 putative substrate translocation pore; other site 511145001080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 511145001081 Predicted esterase [General function prediction only]; Region: COG0627 511145001082 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 511145001083 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 511145001084 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 511145001085 substrate binding site [chemical binding]; other site 511145001086 catalytic Zn binding site [ion binding]; other site 511145001087 NAD binding site [chemical binding]; other site 511145001088 structural Zn binding site [ion binding]; other site 511145001089 dimer interface [polypeptide binding]; other site 511145001090 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 511145001091 putative metal binding site [ion binding]; other site 511145001092 putative homodimer interface [polypeptide binding]; other site 511145001093 putative homotetramer interface [polypeptide binding]; other site 511145001094 putative homodimer-homodimer interface [polypeptide binding]; other site 511145001095 putative allosteric switch controlling residues; other site 511145001096 IS2 repressor TnpA; Reviewed; Region: PRK09413 511145001097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145001098 IS2 transposase TnpB; Reviewed; Region: PRK09409 511145001099 HTH-like domain; Region: HTH_21; pfam13276 511145001100 Integrase core domain; Region: rve; pfam00665 511145001101 Integrase core domain; Region: rve_3; pfam13683 511145001102 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 511145001103 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511145001104 DXD motif; other site 511145001105 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 511145001106 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 511145001107 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145001108 substrate binding pocket [chemical binding]; other site 511145001109 membrane-bound complex binding site; other site 511145001110 hinge residues; other site 511145001111 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 511145001112 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 511145001113 Walker A/P-loop; other site 511145001114 ATP binding site [chemical binding]; other site 511145001115 Q-loop/lid; other site 511145001116 ABC transporter signature motif; other site 511145001117 Walker B; other site 511145001118 D-loop; other site 511145001119 H-loop/switch region; other site 511145001120 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 511145001121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145001122 dimer interface [polypeptide binding]; other site 511145001123 conserved gate region; other site 511145001124 putative PBP binding loops; other site 511145001125 ABC-ATPase subunit interface; other site 511145001126 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 511145001127 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 511145001128 active site 511145001129 iron coordination sites [ion binding]; other site 511145001130 substrate binding pocket [chemical binding]; other site 511145001131 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 511145001132 dimer interface [polypeptide binding]; other site 511145001133 active site 511145001134 Schiff base residues; other site 511145001135 putative transposase OrfB; Reviewed; Region: PHA02517 511145001136 HTH-like domain; Region: HTH_21; pfam13276 511145001137 Integrase core domain; Region: rve; pfam00665 511145001138 Integrase core domain; Region: rve_2; pfam13333 511145001139 Transposase; Region: HTH_Tnp_1; cl17663 511145001140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145001141 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 511145001142 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 511145001143 microcin B17 transporter; Reviewed; Region: PRK11098 511145001144 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 511145001145 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 511145001146 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 511145001147 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 511145001148 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 511145001149 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 511145001150 anti-RssB factor; Provisional; Region: PRK10244 511145001151 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 511145001152 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 511145001153 dimer interface [polypeptide binding]; other site 511145001154 active site 511145001155 hypothetical protein; Provisional; Region: PRK11505 511145001156 psiF repeat; Region: PsiF_repeat; pfam07769 511145001157 psiF repeat; Region: PsiF_repeat; pfam07769 511145001158 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 511145001159 MASE2 domain; Region: MASE2; pfam05230 511145001160 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145001161 metal binding site [ion binding]; metal-binding site 511145001162 active site 511145001163 I-site; other site 511145001164 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 511145001165 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 511145001166 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 511145001167 hypothetical protein; Validated; Region: PRK00124 511145001168 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 511145001169 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 511145001170 ADP binding site [chemical binding]; other site 511145001171 magnesium binding site [ion binding]; other site 511145001172 putative shikimate binding site; other site 511145001173 hypothetical protein; Provisional; Region: PRK10380 511145001174 hypothetical protein; Provisional; Region: PRK10481 511145001175 hypothetical protein; Provisional; Region: PRK10579 511145001176 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 511145001177 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511145001178 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145001179 nucleotide binding site [chemical binding]; other site 511145001180 MFS transport protein AraJ; Provisional; Region: PRK10091 511145001181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145001182 putative substrate translocation pore; other site 511145001183 exonuclease subunit SbcC; Provisional; Region: PRK10246 511145001184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145001185 Walker A/P-loop; other site 511145001186 ATP binding site [chemical binding]; other site 511145001187 Q-loop/lid; other site 511145001188 HemX; Region: HemX; cl19375 511145001189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145001190 ABC transporter signature motif; other site 511145001191 Walker B; other site 511145001192 D-loop; other site 511145001193 H-loop/switch region; other site 511145001194 exonuclease subunit SbcD; Provisional; Region: PRK10966 511145001195 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 511145001196 active site 511145001197 metal binding site [ion binding]; metal-binding site 511145001198 DNA binding site [nucleotide binding] 511145001199 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 511145001200 transcriptional regulator PhoB; Provisional; Region: PRK10161 511145001201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145001202 active site 511145001203 phosphorylation site [posttranslational modification] 511145001204 intermolecular recognition site; other site 511145001205 dimerization interface [polypeptide binding]; other site 511145001206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145001207 DNA binding site [nucleotide binding] 511145001208 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 511145001209 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 511145001210 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145001211 putative active site [active] 511145001212 heme pocket [chemical binding]; other site 511145001213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145001214 dimer interface [polypeptide binding]; other site 511145001215 phosphorylation site [posttranslational modification] 511145001216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145001217 ATP binding site [chemical binding]; other site 511145001218 Mg2+ binding site [ion binding]; other site 511145001219 G-X-G motif; other site 511145001220 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 511145001221 putative proline-specific permease; Provisional; Region: proY; PRK10580 511145001222 Spore germination protein; Region: Spore_permease; cl17796 511145001223 maltodextrin glucosidase; Provisional; Region: PRK10785 511145001224 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 511145001225 homodimer interface [polypeptide binding]; other site 511145001226 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 511145001227 active site 511145001228 homodimer interface [polypeptide binding]; other site 511145001229 catalytic site [active] 511145001230 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 511145001231 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 511145001232 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 511145001233 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 511145001234 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 511145001235 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 511145001236 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 511145001237 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 511145001238 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 511145001239 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 511145001240 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 511145001241 Protein export membrane protein; Region: SecD_SecF; pfam02355 511145001242 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 511145001243 active site 511145001244 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 511145001245 hypothetical protein; Provisional; Region: PRK11530 511145001246 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 511145001247 ATP cone domain; Region: ATP-cone; pfam03477 511145001248 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 511145001249 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 511145001250 catalytic motif [active] 511145001251 Zn binding site [ion binding]; other site 511145001252 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 511145001253 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 511145001254 homopentamer interface [polypeptide binding]; other site 511145001255 active site 511145001256 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 511145001257 thiamine monophosphate kinase; Provisional; Region: PRK05731 511145001258 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 511145001259 ATP binding site [chemical binding]; other site 511145001260 dimerization interface [polypeptide binding]; other site 511145001261 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 511145001262 tetramer interfaces [polypeptide binding]; other site 511145001263 binuclear metal-binding site [ion binding]; other site 511145001264 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511145001265 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 511145001266 active site 511145001267 catalytic tetrad [active] 511145001268 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 511145001269 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 511145001270 TPP-binding site; other site 511145001271 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 511145001272 PYR/PP interface [polypeptide binding]; other site 511145001273 dimer interface [polypeptide binding]; other site 511145001274 TPP binding site [chemical binding]; other site 511145001275 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511145001276 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511145001277 substrate binding pocket [chemical binding]; other site 511145001278 chain length determination region; other site 511145001279 active site lid residues [active] 511145001280 substrate-Mg2+ binding site; other site 511145001281 catalytic residues [active] 511145001282 aspartate-rich region 1; other site 511145001283 aspartate-rich region 2; other site 511145001284 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 511145001285 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 511145001286 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 511145001287 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 511145001288 Ligand Binding Site [chemical binding]; other site 511145001289 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511145001290 active site residue [active] 511145001291 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 511145001292 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 511145001293 conserved cys residue [active] 511145001294 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 511145001295 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 511145001296 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 511145001297 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 511145001298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145001299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511145001300 putative substrate translocation pore; other site 511145001301 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 511145001302 putative active site [active] 511145001303 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 511145001304 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 511145001305 Subunit I/III interface [polypeptide binding]; other site 511145001306 Subunit III/IV interface [polypeptide binding]; other site 511145001307 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 511145001308 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 511145001309 D-pathway; other site 511145001310 Putative ubiquinol binding site [chemical binding]; other site 511145001311 Low-spin heme (heme b) binding site [chemical binding]; other site 511145001312 Putative water exit pathway; other site 511145001313 Binuclear center (heme o3/CuB) [ion binding]; other site 511145001314 K-pathway; other site 511145001315 Putative proton exit pathway; other site 511145001316 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 511145001317 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 511145001318 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 511145001319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145001320 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511145001321 putative substrate translocation pore; other site 511145001322 hypothetical protein; Provisional; Region: PRK11627 511145001323 transcriptional regulator BolA; Provisional; Region: PRK11628 511145001324 trigger factor; Provisional; Region: tig; PRK01490 511145001325 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 511145001326 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 511145001327 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 511145001328 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 511145001329 oligomer interface [polypeptide binding]; other site 511145001330 active site residues [active] 511145001331 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 511145001332 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 511145001333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145001334 Walker A motif; other site 511145001335 ATP binding site [chemical binding]; other site 511145001336 Walker B motif; other site 511145001337 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 511145001338 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 511145001339 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 511145001340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145001341 Walker A motif; other site 511145001342 ATP binding site [chemical binding]; other site 511145001343 Walker B motif; other site 511145001344 arginine finger; other site 511145001345 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 511145001346 histone-like DNA-binding protein HU; Region: HU; cd13831 511145001347 dimer interface [polypeptide binding]; other site 511145001348 DNA binding site [nucleotide binding] 511145001349 periplasmic folding chaperone; Provisional; Region: PRK10788 511145001350 SurA N-terminal domain; Region: SurA_N_3; cl07813 511145001351 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 511145001352 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 511145001353 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 511145001354 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 511145001355 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 511145001356 active site 511145001357 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 511145001358 Ligand Binding Site [chemical binding]; other site 511145001359 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 511145001360 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 511145001361 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 511145001362 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 511145001363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145001364 active site 511145001365 motif I; other site 511145001366 motif II; other site 511145001367 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 511145001368 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 511145001369 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511145001370 putative DNA binding site [nucleotide binding]; other site 511145001371 putative Zn2+ binding site [ion binding]; other site 511145001372 AsnC family; Region: AsnC_trans_reg; pfam01037 511145001373 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511145001374 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 511145001375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145001376 Walker A/P-loop; other site 511145001377 ATP binding site [chemical binding]; other site 511145001378 Q-loop/lid; other site 511145001379 ABC transporter signature motif; other site 511145001380 Walker B; other site 511145001381 D-loop; other site 511145001382 H-loop/switch region; other site 511145001383 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 511145001384 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511145001385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145001386 Walker A/P-loop; other site 511145001387 ATP binding site [chemical binding]; other site 511145001388 Q-loop/lid; other site 511145001389 ABC transporter signature motif; other site 511145001390 Walker B; other site 511145001391 D-loop; other site 511145001392 H-loop/switch region; other site 511145001393 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 511145001394 ammonium transporter; Provisional; Region: PRK10666 511145001395 acyl-CoA thioesterase II; Provisional; Region: PRK10526 511145001396 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 511145001397 active site 511145001398 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 511145001399 catalytic triad [active] 511145001400 dimer interface [polypeptide binding]; other site 511145001401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 511145001402 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 511145001403 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 511145001404 DNA binding site [nucleotide binding] 511145001405 active site 511145001406 Uncharacterized conserved protein [Function unknown]; Region: COG5507 511145001407 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 511145001408 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 511145001409 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145001410 Inner membrane protein YlaC; Region: YlaC; pfam10777 511145001411 maltose O-acetyltransferase; Provisional; Region: PRK10092 511145001412 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511145001413 active site 511145001414 substrate binding site [chemical binding]; other site 511145001415 trimer interface [polypeptide binding]; other site 511145001416 CoA binding site [chemical binding]; other site 511145001417 gene expression modulator; Provisional; Region: PRK10945 511145001418 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 511145001419 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 511145001420 MMPL family; Region: MMPL; cl14618 511145001421 MMPL family; Region: MMPL; cl14618 511145001422 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 511145001423 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 511145001424 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145001425 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 511145001426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145001427 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 511145001428 hypothetical protein; Provisional; Region: PRK11281 511145001429 FSIP1 family; Region: FSIP1; pfam15554 511145001430 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 511145001431 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511145001432 hypothetical protein; Provisional; Region: PRK11038 511145001433 primosomal replication protein N''; Provisional; Region: PRK10093 511145001434 hypothetical protein; Provisional; Region: PRK10527 511145001435 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511145001436 active site 511145001437 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 511145001438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145001439 Walker A motif; other site 511145001440 ATP binding site [chemical binding]; other site 511145001441 Walker B motif; other site 511145001442 DNA polymerase III subunit delta'; Validated; Region: PRK08485 511145001443 arginine finger; other site 511145001444 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 511145001445 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 511145001446 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 511145001447 hypothetical protein; Validated; Region: PRK00153 511145001448 recombination protein RecR; Reviewed; Region: recR; PRK00076 511145001449 RecR protein; Region: RecR; pfam02132 511145001450 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 511145001451 putative active site [active] 511145001452 putative metal-binding site [ion binding]; other site 511145001453 tetramer interface [polypeptide binding]; other site 511145001454 heat shock protein 90; Provisional; Region: PRK05218 511145001455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145001456 ATP binding site [chemical binding]; other site 511145001457 Mg2+ binding site [ion binding]; other site 511145001458 G-X-G motif; other site 511145001459 Hsp90 protein; Region: HSP90; pfam00183 511145001460 adenylate kinase; Reviewed; Region: adk; PRK00279 511145001461 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 511145001462 AMP-binding site [chemical binding]; other site 511145001463 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 511145001464 ferrochelatase; Region: hemH; TIGR00109 511145001465 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 511145001466 C-terminal domain interface [polypeptide binding]; other site 511145001467 active site 511145001468 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 511145001469 active site 511145001470 N-terminal domain interface [polypeptide binding]; other site 511145001471 acetyl esterase; Provisional; Region: PRK10162 511145001472 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 511145001473 inosine/guanosine kinase; Provisional; Region: PRK15074 511145001474 adenosine kinase; Provisional; Region: PTZ00247 511145001475 substrate binding site [chemical binding]; other site 511145001476 ATP binding site [chemical binding]; other site 511145001477 putative cation:proton antiport protein; Provisional; Region: PRK10669 511145001478 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 511145001479 TrkA-N domain; Region: TrkA_N; pfam02254 511145001480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145001481 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511145001482 putative substrate translocation pore; other site 511145001483 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 511145001484 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 511145001485 active site 511145001486 metal binding site [ion binding]; metal-binding site 511145001487 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511145001488 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 511145001489 putative deacylase active site [active] 511145001490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 511145001491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145001492 non-specific DNA binding site [nucleotide binding]; other site 511145001493 salt bridge; other site 511145001494 sequence-specific DNA binding site [nucleotide binding]; other site 511145001495 copper exporting ATPase; Provisional; Region: copA; PRK10671 511145001496 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 511145001497 metal-binding site [ion binding] 511145001498 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 511145001499 metal-binding site [ion binding] 511145001500 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511145001501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145001502 motif II; other site 511145001503 glutaminase; Reviewed; Region: PRK12356 511145001504 amino acid transporter; Region: 2A0306; TIGR00909 511145001505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 511145001506 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 511145001507 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 511145001508 DNA binding residues [nucleotide binding] 511145001509 dimer interface [polypeptide binding]; other site 511145001510 copper binding site [ion binding]; other site 511145001511 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 511145001512 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 511145001513 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 511145001514 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 511145001515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145001516 Walker A/P-loop; other site 511145001517 ATP binding site [chemical binding]; other site 511145001518 Q-loop/lid; other site 511145001519 ABC transporter signature motif; other site 511145001520 Walker B; other site 511145001521 D-loop; other site 511145001522 H-loop/switch region; other site 511145001523 TIGR00245 family protein; Region: TIGR00245 511145001524 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 511145001525 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 511145001526 Tetratricopeptide repeat; Region: TPR_20; pfam14561 511145001527 short chain dehydrogenase; Validated; Region: PRK06182 511145001528 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 511145001529 NADP binding site [chemical binding]; other site 511145001530 active site 511145001531 steroid binding site; other site 511145001532 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 511145001533 active site 511145001534 catalytic triad [active] 511145001535 oxyanion hole [active] 511145001536 switch loop; other site 511145001537 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 511145001538 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511145001539 Walker A/P-loop; other site 511145001540 ATP binding site [chemical binding]; other site 511145001541 Q-loop/lid; other site 511145001542 ABC transporter signature motif; other site 511145001543 Walker B; other site 511145001544 D-loop; other site 511145001545 H-loop/switch region; other site 511145001546 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 511145001547 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511145001548 FtsX-like permease family; Region: FtsX; pfam02687 511145001549 FtsX-like permease family; Region: FtsX; pfam02687 511145001550 PAAR motif; Region: PAAR_motif; cl15808 511145001551 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 511145001552 RHS Repeat; Region: RHS_repeat; pfam05593 511145001553 RHS Repeat; Region: RHS_repeat; pfam05593 511145001554 RHS Repeat; Region: RHS_repeat; pfam05593 511145001555 RHS Repeat; Region: RHS_repeat; pfam05593 511145001556 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 511145001557 RHS Repeat; Region: RHS_repeat; pfam05593 511145001558 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 511145001559 RHS Repeat; Region: RHS_repeat; pfam05593 511145001560 Erythromycin esterase; Region: Erythro_esteras; cl17110 511145001561 RHS protein; Region: RHS; pfam03527 511145001562 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 511145001563 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 511145001564 NTF2 fold immunity protein; Region: Imm-NTF2-2; pfam15631 511145001565 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 511145001566 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 511145001567 active site residue [active] 511145001568 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 511145001569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145001570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145001571 dimerization interface [polypeptide binding]; other site 511145001572 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 511145001573 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 511145001574 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 511145001575 Bacterial transcriptional regulator; Region: IclR; pfam01614 511145001576 glyoxylate carboligase; Provisional; Region: PRK11269 511145001577 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 511145001578 PYR/PP interface [polypeptide binding]; other site 511145001579 dimer interface [polypeptide binding]; other site 511145001580 TPP binding site [chemical binding]; other site 511145001581 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511145001582 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 511145001583 TPP-binding site [chemical binding]; other site 511145001584 hydroxypyruvate isomerase; Provisional; Region: PRK09997 511145001585 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 511145001586 tartronate semialdehyde reductase; Provisional; Region: PRK15059 511145001587 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 511145001588 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 511145001589 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 511145001590 Na binding site [ion binding]; other site 511145001591 substrate binding site [chemical binding]; other site 511145001592 allantoinase; Provisional; Region: PRK08044 511145001593 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 511145001594 active site 511145001595 putative uracil/xanthine transporter; Provisional; Region: PRK11412 511145001596 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 511145001597 glycerate kinase II; Provisional; Region: PRK09932 511145001598 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 511145001599 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 511145001600 Cupin domain; Region: Cupin_2; cl17218 511145001601 allantoate amidohydrolase; Region: AllC; TIGR03176 511145001602 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 511145001603 active site 511145001604 metal binding site [ion binding]; metal-binding site 511145001605 dimer interface [polypeptide binding]; other site 511145001606 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 511145001607 membrane protein FdrA; Validated; Region: PRK06091 511145001608 CoA binding domain; Region: CoA_binding; pfam02629 511145001609 CoA-ligase; Region: Ligase_CoA; pfam00549 511145001610 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 511145001611 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 511145001612 putative substrate binding site [chemical binding]; other site 511145001613 nucleotide binding site [chemical binding]; other site 511145001614 nucleotide binding site [chemical binding]; other site 511145001615 homodimer interface [polypeptide binding]; other site 511145001616 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 511145001617 ATP-grasp domain; Region: ATP-grasp; pfam02222 511145001618 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 511145001619 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 511145001620 putative active site [active] 511145001621 putative metal binding site [ion binding]; other site 511145001622 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 511145001623 substrate binding site [chemical binding]; other site 511145001624 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 511145001625 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511145001626 active site 511145001627 HIGH motif; other site 511145001628 KMSKS motif; other site 511145001629 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 511145001630 tRNA binding surface [nucleotide binding]; other site 511145001631 anticodon binding site; other site 511145001632 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 511145001633 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511145001634 RNA binding surface [nucleotide binding]; other site 511145001635 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 511145001636 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 511145001637 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 511145001638 homodimer interface [polypeptide binding]; other site 511145001639 NADP binding site [chemical binding]; other site 511145001640 substrate binding site [chemical binding]; other site 511145001641 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 511145001642 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 511145001643 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145001644 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145001645 outer membrane usher protein FimD; Provisional; Region: PRK15198 511145001646 PapC N-terminal domain; Region: PapC_N; pfam13954 511145001647 Outer membrane usher protein; Region: Usher; pfam00577 511145001648 PapC C-terminal domain; Region: PapC_C; pfam13953 511145001649 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 511145001650 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 511145001651 transcriptional regulator FimZ; Provisional; Region: PRK09935 511145001652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145001653 active site 511145001654 phosphorylation site [posttranslational modification] 511145001655 intermolecular recognition site; other site 511145001656 dimerization interface [polypeptide binding]; other site 511145001657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145001658 DNA binding residues [nucleotide binding] 511145001659 dimerization interface [polypeptide binding]; other site 511145001660 cryptic prophage DLP12 511145001661 integrase; Provisional; Region: int; PHA02601 511145001662 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 511145001663 Int/Topo IB signature motif; other site 511145001664 Transposase; Region: HTH_Tnp_1; cl17663 511145001665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145001666 putative transposase OrfB; Reviewed; Region: PHA02517 511145001667 HTH-like domain; Region: HTH_21; pfam13276 511145001668 Integrase core domain; Region: rve; pfam00665 511145001669 Integrase core domain; Region: rve_2; pfam13333 511145001670 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 511145001671 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 511145001672 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 511145001673 catalytic residues [active] 511145001674 catalytic nucleophile [active] 511145001675 Recombinase; Region: Recombinase; pfam07508 511145001676 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 511145001677 Defensin propeptide; Region: Defensin_propep; pfam00879 511145001678 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 511145001679 substrate binding site [chemical binding]; other site 511145001680 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511145001681 hypothetical protein; Provisional; Region: PRK09741 511145001682 prophage protein NinE; Provisional; Region: PRK09689 511145001683 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 511145001684 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 511145001685 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 511145001686 Transposase domain (DUF772); Region: DUF772; pfam05598 511145001687 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145001688 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145001689 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145001690 Lysis protein S; Region: Lysis_S; pfam04971 511145001691 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 511145001692 catalytic residues [active] 511145001693 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 511145001694 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 511145001695 Bor protein; Region: Lambda_Bor; pfam06291 511145001696 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 511145001697 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 511145001698 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 511145001699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145001700 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511145001701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145001702 outer membrane protease; Reviewed; Region: PRK10993 511145001703 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 511145001704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145001705 hypothetical protein; Provisional; Region: PRK09936 511145001706 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 511145001707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145001708 TPR motif; other site 511145001709 binding surface 511145001710 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 511145001711 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 511145001712 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 511145001713 active site 511145001714 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 511145001715 sensor kinase CusS; Provisional; Region: PRK09835 511145001716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145001717 dimerization interface [polypeptide binding]; other site 511145001718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145001719 dimer interface [polypeptide binding]; other site 511145001720 phosphorylation site [posttranslational modification] 511145001721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145001722 ATP binding site [chemical binding]; other site 511145001723 Mg2+ binding site [ion binding]; other site 511145001724 G-X-G motif; other site 511145001725 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 511145001726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145001727 active site 511145001728 phosphorylation site [posttranslational modification] 511145001729 intermolecular recognition site; other site 511145001730 dimerization interface [polypeptide binding]; other site 511145001731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145001732 DNA binding site [nucleotide binding] 511145001733 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 511145001734 Outer membrane efflux protein; Region: OEP; pfam02321 511145001735 Outer membrane efflux protein; Region: OEP; pfam02321 511145001736 periplasmic copper-binding protein; Provisional; Region: PRK09838 511145001737 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 511145001738 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145001739 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 511145001740 phenylalanine transporter; Provisional; Region: PRK10249 511145001741 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145001742 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 511145001743 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511145001744 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 511145001745 dimer interface [polypeptide binding]; other site 511145001746 FMN binding site [chemical binding]; other site 511145001747 hypothetical protein; Provisional; Region: PRK10250 511145001748 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 511145001749 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 511145001750 Hok/gef family; Region: HOK_GEF; pfam01848 511145001751 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 511145001752 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511145001753 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 511145001754 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 511145001755 outer membrane receptor FepA; Provisional; Region: PRK13524 511145001756 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 511145001757 N-terminal plug; other site 511145001758 ligand-binding site [chemical binding]; other site 511145001759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 511145001760 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 511145001761 Condensation domain; Region: Condensation; pfam00668 511145001762 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 511145001763 acyl-activating enzyme (AAE) consensus motif; other site 511145001764 AMP binding site [chemical binding]; other site 511145001765 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 511145001766 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 511145001767 LPS O-antigen length regulator; Provisional; Region: PRK10381 511145001768 Chain length determinant protein; Region: Wzz; pfam02706 511145001769 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 511145001770 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 511145001771 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511145001772 Walker A/P-loop; other site 511145001773 ATP binding site [chemical binding]; other site 511145001774 Q-loop/lid; other site 511145001775 ABC transporter signature motif; other site 511145001776 Walker B; other site 511145001777 D-loop; other site 511145001778 H-loop/switch region; other site 511145001779 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511145001780 ABC-ATPase subunit interface; other site 511145001781 dimer interface [polypeptide binding]; other site 511145001782 putative PBP binding regions; other site 511145001783 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511145001784 ABC-ATPase subunit interface; other site 511145001785 dimer interface [polypeptide binding]; other site 511145001786 putative PBP binding regions; other site 511145001787 enterobactin exporter EntS; Provisional; Region: PRK10489 511145001788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145001789 putative substrate translocation pore; other site 511145001790 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 511145001791 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 511145001792 siderophore binding site; other site 511145001793 isochorismate synthase EntC; Provisional; Region: PRK15016 511145001794 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 511145001795 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 511145001796 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 511145001797 acyl-activating enzyme (AAE) consensus motif; other site 511145001798 active site 511145001799 AMP binding site [chemical binding]; other site 511145001800 substrate binding site [chemical binding]; other site 511145001801 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 511145001802 hydrophobic substrate binding pocket; other site 511145001803 active site 511145001804 conserved cis-peptide bond; other site 511145001805 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 511145001806 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 511145001807 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 511145001808 putative NAD(P) binding site [chemical binding]; other site 511145001809 active site 511145001810 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 511145001811 CoenzymeA binding site [chemical binding]; other site 511145001812 subunit interaction site [polypeptide binding]; other site 511145001813 PHB binding site; other site 511145001814 carbon starvation protein A; Provisional; Region: PRK15015 511145001815 Carbon starvation protein CstA; Region: CstA; pfam02554 511145001816 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 511145001817 Uncharacterized small protein [Function unknown]; Region: COG2879 511145001818 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 511145001819 putative active site [active] 511145001820 metal binding site [ion binding]; metal-binding site 511145001821 methionine aminotransferase; Validated; Region: PRK09082 511145001822 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145001823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145001824 homodimer interface [polypeptide binding]; other site 511145001825 catalytic residue [active] 511145001826 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 511145001827 ParB-like nuclease domain; Region: ParBc; pfam02195 511145001828 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 511145001829 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 511145001830 Active Sites [active] 511145001831 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 511145001832 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 511145001833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145001834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145001835 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 511145001836 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 511145001837 dimerization domain [polypeptide binding]; other site 511145001838 dimer interface [polypeptide binding]; other site 511145001839 catalytic residues [active] 511145001840 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 511145001841 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 511145001842 dimer interface [polypeptide binding]; other site 511145001843 decamer (pentamer of dimers) interface [polypeptide binding]; other site 511145001844 catalytic triad [active] 511145001845 peroxidatic and resolving cysteines [active] 511145001846 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 511145001847 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 511145001848 catalytic residue [active] 511145001849 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 511145001850 catalytic residues [active] 511145001851 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145001852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145001853 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511145001854 Ligand Binding Site [chemical binding]; other site 511145001855 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 511145001856 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511145001857 NAD binding site [chemical binding]; other site 511145001858 catalytic Zn binding site [ion binding]; other site 511145001859 structural Zn binding site [ion binding]; other site 511145001860 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 511145001861 Rnk N-terminus; Region: Rnk_N; pfam14760 511145001862 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511145001863 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 511145001864 B1 nucleotide binding pocket [chemical binding]; other site 511145001865 B2 nucleotide binding pocket [chemical binding]; other site 511145001866 CAS motifs; other site 511145001867 active site 511145001868 anion transporter; Region: dass; TIGR00785 511145001869 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 511145001870 transmembrane helices; other site 511145001871 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 511145001872 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 511145001873 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 511145001874 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 511145001875 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 511145001876 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 511145001877 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 511145001878 putative active site [active] 511145001879 (T/H)XGH motif; other site 511145001880 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 511145001881 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 511145001882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145001883 putative active site [active] 511145001884 heme pocket [chemical binding]; other site 511145001885 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 511145001886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145001887 ATP binding site [chemical binding]; other site 511145001888 Mg2+ binding site [ion binding]; other site 511145001889 G-X-G motif; other site 511145001890 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 511145001891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145001892 active site 511145001893 phosphorylation site [posttranslational modification] 511145001894 intermolecular recognition site; other site 511145001895 dimerization interface [polypeptide binding]; other site 511145001896 Transcriptional regulator; Region: CitT; pfam12431 511145001897 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 511145001898 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 511145001899 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 511145001900 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511145001901 DNA-binding site [nucleotide binding]; DNA binding site 511145001902 RNA-binding motif; other site 511145001903 chromosome condensation membrane protein; Provisional; Region: PRK14196 511145001904 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 511145001905 lipoyl synthase; Provisional; Region: PRK05481 511145001906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145001907 FeS/SAM binding site; other site 511145001908 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 511145001909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145001910 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145001911 dimerization interface [polypeptide binding]; other site 511145001912 lipoate-protein ligase B; Provisional; Region: PRK14342 511145001913 hypothetical protein; Provisional; Region: PRK04998 511145001914 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 511145001915 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 511145001916 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 511145001917 rare lipoprotein A; Provisional; Region: PRK10672 511145001918 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 511145001919 Sporulation related domain; Region: SPOR; pfam05036 511145001920 cell wall shape-determining protein; Provisional; Region: PRK10794 511145001921 penicillin-binding protein 2; Provisional; Region: PRK10795 511145001922 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 511145001923 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511145001924 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 511145001925 ribosome-associated protein; Provisional; Region: PRK11538 511145001926 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511145001927 catalytic core [active] 511145001928 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 511145001929 active site 511145001930 (T/H)XGH motif; other site 511145001931 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 511145001932 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 511145001933 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 511145001934 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 511145001935 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 511145001936 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 511145001937 active site 511145001938 HIGH motif; other site 511145001939 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511145001940 KMSKS motif; other site 511145001941 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 511145001942 tRNA binding surface [nucleotide binding]; other site 511145001943 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511145001944 hypothetical protein; Provisional; Region: PRK11032 511145001945 Sel1-like repeats; Region: SEL1; smart00671 511145001946 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 511145001947 Sel1-like repeats; Region: SEL1; smart00671 511145001948 Sel1-like repeats; Region: SEL1; smart00671 511145001949 Sel1-like repeats; Region: SEL1; smart00671 511145001950 Sel1-like repeats; Region: SEL1; smart00671 511145001951 Sel1-like repeats; Region: SEL1; smart00671 511145001952 Sel1-like repeats; Region: SEL1; smart00671 511145001953 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 511145001954 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511145001955 HSP70 interaction site [polypeptide binding]; other site 511145001956 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 511145001957 Sel1-like repeats; Region: SEL1; smart00671 511145001958 Sel1-like repeats; Region: SEL1; smart00671 511145001959 Sel1-like repeats; Region: SEL1; smart00671 511145001960 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 511145001961 DnaJ domain; Region: DnaJ; pfam00226 511145001962 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 511145001963 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 511145001964 nucleotide binding site [chemical binding]; other site 511145001965 putative NEF/HSP70 interaction site [polypeptide binding]; other site 511145001966 SBD interface [polypeptide binding]; other site 511145001967 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 511145001968 active site 511145001969 tetramer interface [polypeptide binding]; other site 511145001970 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511145001971 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511145001972 Walker A/P-loop; other site 511145001973 ATP binding site [chemical binding]; other site 511145001974 Q-loop/lid; other site 511145001975 ABC transporter signature motif; other site 511145001976 Walker B; other site 511145001977 D-loop; other site 511145001978 H-loop/switch region; other site 511145001979 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 511145001980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145001981 dimer interface [polypeptide binding]; other site 511145001982 conserved gate region; other site 511145001983 putative PBP binding loops; other site 511145001984 ABC-ATPase subunit interface; other site 511145001985 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 511145001986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145001987 dimer interface [polypeptide binding]; other site 511145001988 conserved gate region; other site 511145001989 putative PBP binding loops; other site 511145001990 ABC-ATPase subunit interface; other site 511145001991 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 511145001992 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145001993 substrate binding pocket [chemical binding]; other site 511145001994 membrane-bound complex binding site; other site 511145001995 hinge residues; other site 511145001996 Transposase domain (DUF772); Region: DUF772; pfam05598 511145001997 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145001998 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145001999 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145002000 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 511145002001 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 511145002002 putative active site [active] 511145002003 catalytic triad [active] 511145002004 putative dimer interface [polypeptide binding]; other site 511145002005 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 511145002006 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511145002007 Transporter associated domain; Region: CorC_HlyC; smart01091 511145002008 metal-binding heat shock protein; Provisional; Region: PRK00016 511145002009 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 511145002010 PhoH-like protein; Region: PhoH; pfam02562 511145002011 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 511145002012 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511145002013 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145002014 FeS/SAM binding site; other site 511145002015 TRAM domain; Region: TRAM; pfam01938 511145002016 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 511145002017 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 511145002018 asparagine synthetase B; Provisional; Region: asnB; PRK09431 511145002019 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 511145002020 active site 511145002021 dimer interface [polypeptide binding]; other site 511145002022 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 511145002023 Ligand Binding Site [chemical binding]; other site 511145002024 Molecular Tunnel; other site 511145002025 UMP phosphatase; Provisional; Region: PRK10444 511145002026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145002027 active site 511145002028 motif I; other site 511145002029 motif II; other site 511145002030 MarR family; Region: MarR_2; cl17246 511145002031 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511145002032 ROK family; Region: ROK; pfam00480 511145002033 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 511145002034 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 511145002035 active site 511145002036 dimer interface [polypeptide binding]; other site 511145002037 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 511145002038 active site 511145002039 trimer interface [polypeptide binding]; other site 511145002040 allosteric site; other site 511145002041 active site lid [active] 511145002042 hexamer (dimer of trimers) interface [polypeptide binding]; other site 511145002043 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 511145002044 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511145002045 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511145002046 active site turn [active] 511145002047 phosphorylation site [posttranslational modification] 511145002048 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 511145002049 HPr interaction site; other site 511145002050 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511145002051 active site 511145002052 phosphorylation site [posttranslational modification] 511145002053 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 511145002054 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 511145002055 active site 511145002056 HIGH motif; other site 511145002057 KMSKS motif; other site 511145002058 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 511145002059 outer membrane porin, OprD family; Region: OprD; pfam03573 511145002060 YbfN-like lipoprotein; Region: YbfN; pfam13982 511145002061 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 511145002062 metal binding site 2 [ion binding]; metal-binding site 511145002063 putative DNA binding helix; other site 511145002064 metal binding site 1 [ion binding]; metal-binding site 511145002065 dimer interface [polypeptide binding]; other site 511145002066 structural Zn2+ binding site [ion binding]; other site 511145002067 ryhB-regulated fur leader peptide; Provisional; Region: PRK14761 511145002068 flavodoxin FldA; Validated; Region: PRK09267 511145002069 LexA regulated protein; Provisional; Region: PRK11675 511145002070 acyl-CoA esterase; Provisional; Region: PRK10673 511145002071 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511145002072 replication initiation regulator SeqA; Provisional; Region: PRK11187 511145002073 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 511145002074 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 511145002075 active site 511145002076 substrate binding site [chemical binding]; other site 511145002077 metal binding site [ion binding]; metal-binding site 511145002078 putrescine transporter; Provisional; Region: potE; PRK10655 511145002079 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 511145002080 ornithine decarboxylase; Provisional; Region: PRK13578 511145002081 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 511145002082 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 511145002083 homodimer interface [polypeptide binding]; other site 511145002084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145002085 catalytic residue [active] 511145002086 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 511145002087 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 511145002088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145002089 active site 511145002090 phosphorylation site [posttranslational modification] 511145002091 intermolecular recognition site; other site 511145002092 dimerization interface [polypeptide binding]; other site 511145002093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145002094 DNA binding site [nucleotide binding] 511145002095 sensor protein KdpD; Provisional; Region: PRK10490 511145002096 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 511145002097 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 511145002098 Ligand Binding Site [chemical binding]; other site 511145002099 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 511145002100 GAF domain; Region: GAF_3; pfam13492 511145002101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145002102 dimer interface [polypeptide binding]; other site 511145002103 phosphorylation site [posttranslational modification] 511145002104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145002105 ATP binding site [chemical binding]; other site 511145002106 Mg2+ binding site [ion binding]; other site 511145002107 G-X-G motif; other site 511145002108 K+-transporting ATPase, c chain; Region: KdpC; pfam02669 511145002109 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 511145002110 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511145002111 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511145002112 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 511145002113 potassium-transporting ATPase subunit F; Provisional; Region: kdpF; PRK14748 511145002114 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 511145002115 PAAR motif; Region: PAAR_motif; cl15808 511145002116 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 511145002117 RHS Repeat; Region: RHS_repeat; pfam05593 511145002118 RHS Repeat; Region: RHS_repeat; pfam05593 511145002119 RHS Repeat; Region: RHS_repeat; pfam05593 511145002120 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 511145002121 RHS Repeat; Region: RHS_repeat; pfam05593 511145002122 RHS Repeat; Region: RHS_repeat; pfam05593 511145002123 RHS protein; Region: RHS; pfam03527 511145002124 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 511145002125 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 511145002126 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511145002127 Transposase [DNA replication, recombination, and repair]; Region: COG5433 511145002128 hypothetical protein; Provisional; Region: PRK10167 511145002129 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 511145002130 DNA photolyase; Region: DNA_photolyase; pfam00875 511145002131 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 511145002132 dipeptide/tripeptide permease D; Provisional; Region: PRK15462 511145002133 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 511145002134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145002135 putative substrate translocation pore; other site 511145002136 metal-binding protein; Provisional; Region: PRK10799 511145002137 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 511145002138 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 511145002139 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 511145002140 putative active site [active] 511145002141 endonuclease VIII; Provisional; Region: PRK10445 511145002142 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 511145002143 DNA binding site [nucleotide binding] 511145002144 catalytic residue [active] 511145002145 putative catalytic residues [active] 511145002146 H2TH interface [polypeptide binding]; other site 511145002147 intercalation triad [nucleotide binding]; other site 511145002148 substrate specificity determining residue; other site 511145002149 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 511145002150 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511145002151 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 511145002152 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 511145002153 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 511145002154 Fimbrial protein; Region: Fimbrial; pfam00419 511145002155 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 511145002156 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145002157 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145002158 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 511145002159 PapC N-terminal domain; Region: PapC_N; pfam13954 511145002160 Outer membrane usher protein; Region: Usher; pfam00577 511145002161 PapC C-terminal domain; Region: PapC_C; pfam13953 511145002162 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 511145002163 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 511145002164 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 511145002165 dimer interface [polypeptide binding]; other site 511145002166 active site 511145002167 citrylCoA binding site [chemical binding]; other site 511145002168 NADH binding [chemical binding]; other site 511145002169 cationic pore residues; other site 511145002170 oxalacetate/citrate binding site [chemical binding]; other site 511145002171 coenzyme A binding site [chemical binding]; other site 511145002172 catalytic triad [active] 511145002173 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 511145002174 Iron-sulfur protein interface; other site 511145002175 proximal quinone binding site [chemical binding]; other site 511145002176 SdhD (CybS) interface [polypeptide binding]; other site 511145002177 proximal heme binding site [chemical binding]; other site 511145002178 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 511145002179 SdhC subunit interface [polypeptide binding]; other site 511145002180 proximal heme binding site [chemical binding]; other site 511145002181 cardiolipin binding site; other site 511145002182 Iron-sulfur protein interface; other site 511145002183 proximal quinone binding site [chemical binding]; other site 511145002184 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 511145002185 L-aspartate oxidase; Provisional; Region: PRK06175 511145002186 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 511145002187 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 511145002188 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 511145002189 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 511145002190 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 511145002191 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 511145002192 TPP-binding site [chemical binding]; other site 511145002193 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 511145002194 dimer interface [polypeptide binding]; other site 511145002195 PYR/PP interface [polypeptide binding]; other site 511145002196 TPP binding site [chemical binding]; other site 511145002197 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 511145002198 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511145002199 E3 interaction surface; other site 511145002200 lipoyl attachment site [posttranslational modification]; other site 511145002201 e3 binding domain; Region: E3_binding; pfam02817 511145002202 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 511145002203 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 511145002204 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 511145002205 CoA-ligase; Region: Ligase_CoA; pfam00549 511145002206 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 511145002207 CoA binding domain; Region: CoA_binding; pfam02629 511145002208 CoA-ligase; Region: Ligase_CoA; pfam00549 511145002209 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 511145002210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145002211 DNA-binding site [nucleotide binding]; DNA binding site 511145002212 UTRA domain; Region: UTRA; pfam07702 511145002213 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 511145002214 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145002215 active site 511145002216 phosphorylation site [posttranslational modification] 511145002217 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 511145002218 active site 511145002219 P-loop; other site 511145002220 phosphorylation site [posttranslational modification] 511145002221 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 511145002222 alpha-mannosidase; Provisional; Region: PRK09819 511145002223 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 511145002224 active site 511145002225 metal binding site [ion binding]; metal-binding site 511145002226 catalytic site [active] 511145002227 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 511145002228 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 511145002229 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 511145002230 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 511145002231 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 511145002232 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 511145002233 hypothetical protein; Provisional; Region: PRK10588 511145002234 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 511145002235 active site 511145002236 colicin uptake protein TolQ; Provisional; Region: PRK10801 511145002237 colicin uptake protein TolR; Provisional; Region: PRK11024 511145002238 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 511145002239 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 511145002240 TolA C-terminal; Region: TolA; pfam06519 511145002241 translocation protein TolB; Provisional; Region: tolB; PRK03629 511145002242 TolB amino-terminal domain; Region: TolB_N; pfam04052 511145002243 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 511145002244 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 511145002245 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 511145002246 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 511145002247 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 511145002248 ligand binding site [chemical binding]; other site 511145002249 tol-pal system protein YbgF; Provisional; Region: PRK10803 511145002250 Tetratricopeptide repeat; Region: TPR_6; pfam13174 511145002251 Tetratricopeptide repeat; Region: TPR_6; pfam13174 511145002252 quinolinate synthetase; Provisional; Region: PRK09375 511145002253 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 511145002254 zinc transporter ZitB; Provisional; Region: PRK03557 511145002255 YbgS-like protein; Region: YbgS; pfam13985 511145002256 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 511145002257 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511145002258 catalytic core [active] 511145002259 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 511145002260 active site 511145002261 catalytic residues [active] 511145002262 galactokinase; Provisional; Region: PRK05101 511145002263 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 511145002264 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511145002265 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511145002266 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 511145002267 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 511145002268 dimer interface [polypeptide binding]; other site 511145002269 active site 511145002270 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 511145002271 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 511145002272 NAD binding site [chemical binding]; other site 511145002273 homodimer interface [polypeptide binding]; other site 511145002274 active site 511145002275 substrate binding site [chemical binding]; other site 511145002276 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 511145002277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 511145002278 Walker A/P-loop; other site 511145002279 ATP binding site [chemical binding]; other site 511145002280 Q-loop/lid; other site 511145002281 ABC transporter signature motif; other site 511145002282 Walker B; other site 511145002283 D-loop; other site 511145002284 H-loop/switch region; other site 511145002285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145002286 Walker A/P-loop; other site 511145002287 ATP binding site [chemical binding]; other site 511145002288 Q-loop/lid; other site 511145002289 ABC transporter signature motif; other site 511145002290 Walker B; other site 511145002291 D-loop; other site 511145002292 H-loop/switch region; other site 511145002293 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 511145002294 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 511145002295 molybdenum-pterin binding domain; Region: Mop; TIGR00638 511145002296 TOBE domain; Region: TOBE; pfam03459 511145002297 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 511145002298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145002299 substrate binding pocket [chemical binding]; other site 511145002300 membrane-bound complex binding site; other site 511145002301 hinge residues; other site 511145002302 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 511145002303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145002304 dimer interface [polypeptide binding]; other site 511145002305 conserved gate region; other site 511145002306 putative PBP binding loops; other site 511145002307 ABC-ATPase subunit interface; other site 511145002308 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 511145002309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145002310 Walker A/P-loop; other site 511145002311 ATP binding site [chemical binding]; other site 511145002312 Q-loop/lid; other site 511145002313 ABC transporter signature motif; other site 511145002314 Walker B; other site 511145002315 D-loop; other site 511145002316 H-loop/switch region; other site 511145002317 molybdenum-pterin binding domain; Region: Mop; TIGR00638 511145002318 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 511145002319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145002320 active site 511145002321 motif I; other site 511145002322 motif II; other site 511145002323 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 511145002324 6-phosphogluconolactonase; Provisional; Region: PRK11028 511145002325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145002326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145002327 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 511145002328 putative dimerization interface [polypeptide binding]; other site 511145002329 PrpF protein; Region: PrpF; pfam04303 511145002330 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 511145002331 anion transporter; Region: dass; TIGR00785 511145002332 transmembrane helices; other site 511145002333 putative hydratase; Provisional; Region: PRK11413 511145002334 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 511145002335 substrate binding site [chemical binding]; other site 511145002336 ligand binding site [chemical binding]; other site 511145002337 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 511145002338 substrate binding site [chemical binding]; other site 511145002339 acyl-CoA thioesterase; Provisional; Region: PRK10531 511145002340 Pectinesterase; Region: Pectinesterase; cl01911 511145002341 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 511145002342 substrate binding site [chemical binding]; other site 511145002343 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 511145002344 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511145002345 inhibitor-cofactor binding pocket; inhibition site 511145002346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145002347 catalytic residue [active] 511145002348 biotin synthase; Provisional; Region: PRK15108 511145002349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145002350 FeS/SAM binding site; other site 511145002351 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 511145002352 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 511145002353 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 511145002354 substrate-cofactor binding pocket; other site 511145002355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145002356 catalytic residue [active] 511145002357 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 511145002358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145002359 S-adenosylmethionine binding site [chemical binding]; other site 511145002360 AAA domain; Region: AAA_26; pfam13500 511145002361 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 511145002362 active site 511145002363 ADP binding site [chemical binding]; other site 511145002364 excinuclease ABC subunit B; Provisional; Region: PRK05298 511145002365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145002366 ATP binding site [chemical binding]; other site 511145002367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145002368 nucleotide binding region [chemical binding]; other site 511145002369 ATP-binding site [chemical binding]; other site 511145002370 Ultra-violet resistance protein B; Region: UvrB; pfam12344 511145002371 UvrB/uvrC motif; Region: UVR; pfam02151 511145002372 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 511145002373 phosphate binding site [ion binding]; other site 511145002374 putative substrate binding pocket [chemical binding]; other site 511145002375 dimer interface [polypeptide binding]; other site 511145002376 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 511145002377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145002378 FeS/SAM binding site; other site 511145002379 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 511145002380 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 511145002381 MPT binding site; other site 511145002382 trimer interface [polypeptide binding]; other site 511145002383 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 511145002384 trimer interface [polypeptide binding]; other site 511145002385 dimer interface [polypeptide binding]; other site 511145002386 putative active site [active] 511145002387 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 511145002388 MoaE interaction surface [polypeptide binding]; other site 511145002389 MoeB interaction surface [polypeptide binding]; other site 511145002390 thiocarboxylated glycine; other site 511145002391 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 511145002392 MoaE homodimer interface [polypeptide binding]; other site 511145002393 MoaD interaction [polypeptide binding]; other site 511145002394 active site residues [active] 511145002395 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 511145002396 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 511145002397 Predicted integral membrane protein [Function unknown]; Region: COG0392 511145002398 cardiolipin synthase 2; Provisional; Region: PRK11263 511145002399 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 511145002400 putative active site [active] 511145002401 catalytic site [active] 511145002402 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 511145002403 putative active site [active] 511145002404 catalytic site [active] 511145002405 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 511145002406 putative catalytic site [active] 511145002407 putative metal binding site [ion binding]; other site 511145002408 putative phosphate binding site [ion binding]; other site 511145002409 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 511145002410 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 511145002411 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 511145002412 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 511145002413 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 511145002414 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511145002415 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511145002416 Walker A/P-loop; other site 511145002417 ATP binding site [chemical binding]; other site 511145002418 Q-loop/lid; other site 511145002419 ABC transporter signature motif; other site 511145002420 Walker B; other site 511145002421 D-loop; other site 511145002422 H-loop/switch region; other site 511145002423 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511145002424 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511145002425 Walker A/P-loop; other site 511145002426 ATP binding site [chemical binding]; other site 511145002427 Q-loop/lid; other site 511145002428 ABC transporter signature motif; other site 511145002429 Walker B; other site 511145002430 D-loop; other site 511145002431 H-loop/switch region; other site 511145002432 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 511145002433 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145002434 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145002435 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 511145002436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145002437 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 511145002438 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 511145002439 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511145002440 ATP binding site [chemical binding]; other site 511145002441 Mg++ binding site [ion binding]; other site 511145002442 motif III; other site 511145002443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145002444 nucleotide binding region [chemical binding]; other site 511145002445 ATP-binding site [chemical binding]; other site 511145002446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 511145002447 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 511145002448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 511145002449 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 511145002450 glycosyl transferase family protein; Provisional; Region: PRK08136 511145002451 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511145002452 putative dehydrogenase; Provisional; Region: PRK10098 511145002453 hypothetical protein; Provisional; Region: PRK10259 511145002454 hypothetical protein; Provisional; Region: PRK11019 511145002455 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 511145002456 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 511145002457 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 511145002458 N-terminal plug; other site 511145002459 ligand-binding site [chemical binding]; other site 511145002460 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 511145002461 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 511145002462 putative mechanosensitive channel protein; Provisional; Region: PRK11465 511145002463 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511145002464 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 511145002465 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511145002466 Walker A/P-loop; other site 511145002467 ATP binding site [chemical binding]; other site 511145002468 Q-loop/lid; other site 511145002469 ABC transporter signature motif; other site 511145002470 Walker B; other site 511145002471 D-loop; other site 511145002472 H-loop/switch region; other site 511145002473 glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494 511145002474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145002475 dimer interface [polypeptide binding]; other site 511145002476 conserved gate region; other site 511145002477 putative PBP binding loops; other site 511145002478 ABC-ATPase subunit interface; other site 511145002479 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 511145002480 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145002481 substrate binding pocket [chemical binding]; other site 511145002482 membrane-bound complex binding site; other site 511145002483 hinge residues; other site 511145002484 Ferritin-like domain; Region: Ferritin; pfam00210 511145002485 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 511145002486 dimerization interface [polypeptide binding]; other site 511145002487 DPS ferroxidase diiron center [ion binding]; other site 511145002488 ion pore; other site 511145002489 threonine and homoserine efflux system; Provisional; Region: PRK10532 511145002490 EamA-like transporter family; Region: EamA; pfam00892 511145002491 outer membrane protein X; Provisional; Region: ompX; PRK09408 511145002492 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 511145002493 Sulfatase; Region: Sulfatase; pfam00884 511145002494 manganese transport regulator MntR; Provisional; Region: PRK11050 511145002495 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 511145002496 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 511145002497 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 511145002498 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 511145002499 transmembrane helices; other site 511145002500 L,D-transpeptidase; Provisional; Region: PRK10260 511145002501 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 511145002502 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 511145002503 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511145002504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145002505 Walker A/P-loop; other site 511145002506 ATP binding site [chemical binding]; other site 511145002507 ABC transporter signature motif; other site 511145002508 Walker B; other site 511145002509 ABC transporter; Region: ABC_tran_2; pfam12848 511145002510 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511145002511 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 511145002512 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 511145002513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145002514 active site 511145002515 motif I; other site 511145002516 motif II; other site 511145002517 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 511145002518 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 511145002519 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 511145002520 dimer interface [polypeptide binding]; other site 511145002521 active site 511145002522 glycine loop; other site 511145002523 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 511145002524 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 511145002525 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 511145002526 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 511145002527 active site 511145002528 intersubunit interactions; other site 511145002529 catalytic residue [active] 511145002530 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 511145002531 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 511145002532 ATP binding site [chemical binding]; other site 511145002533 substrate interface [chemical binding]; other site 511145002534 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 511145002535 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 511145002536 dimer interface [polypeptide binding]; other site 511145002537 putative functional site; other site 511145002538 putative MPT binding site; other site 511145002539 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 511145002540 catalytic nucleophile [active] 511145002541 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 511145002542 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145002543 Walker A/P-loop; other site 511145002544 ATP binding site [chemical binding]; other site 511145002545 Q-loop/lid; other site 511145002546 ABC transporter signature motif; other site 511145002547 Walker B; other site 511145002548 D-loop; other site 511145002549 H-loop/switch region; other site 511145002550 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511145002551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145002552 Walker A/P-loop; other site 511145002553 ATP binding site [chemical binding]; other site 511145002554 Q-loop/lid; other site 511145002555 ABC transporter signature motif; other site 511145002556 Walker B; other site 511145002557 D-loop; other site 511145002558 H-loop/switch region; other site 511145002559 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 511145002560 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 511145002561 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 511145002562 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 511145002563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145002564 dimer interface [polypeptide binding]; other site 511145002565 conserved gate region; other site 511145002566 putative PBP binding loops; other site 511145002567 ABC-ATPase subunit interface; other site 511145002568 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 511145002569 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 511145002570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145002571 dimer interface [polypeptide binding]; other site 511145002572 conserved gate region; other site 511145002573 putative PBP binding loops; other site 511145002574 ABC-ATPase subunit interface; other site 511145002575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145002576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145002577 metal binding site [ion binding]; metal-binding site 511145002578 active site 511145002579 I-site; other site 511145002580 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 511145002581 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511145002582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145002583 FeS/SAM binding site; other site 511145002584 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 511145002585 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 511145002586 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 511145002587 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 511145002588 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 511145002589 putative C-terminal domain interface [polypeptide binding]; other site 511145002590 putative GSH binding site (G-site) [chemical binding]; other site 511145002591 putative dimer interface [polypeptide binding]; other site 511145002592 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 511145002593 N-terminal domain interface [polypeptide binding]; other site 511145002594 dimer interface [polypeptide binding]; other site 511145002595 substrate binding pocket (H-site) [chemical binding]; other site 511145002596 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 511145002597 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 511145002598 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 511145002599 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 511145002600 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 511145002601 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145002602 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 511145002603 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 511145002604 active site 511145002605 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 511145002606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145002607 putative substrate translocation pore; other site 511145002608 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 511145002609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145002610 active site 511145002611 motif I; other site 511145002612 motif II; other site 511145002613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145002614 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 511145002615 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 511145002616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145002617 putative substrate translocation pore; other site 511145002618 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 511145002619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145002620 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 511145002621 putative transporter; Provisional; Region: PRK04972 511145002622 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 511145002623 TrkA-C domain; Region: TrkA_C; pfam02080 511145002624 TrkA-C domain; Region: TrkA_C; pfam02080 511145002625 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 511145002626 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 511145002627 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 511145002628 GSH binding site [chemical binding]; other site 511145002629 catalytic residues [active] 511145002630 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 511145002631 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 511145002632 dimer interface [polypeptide binding]; other site 511145002633 FMN binding site [chemical binding]; other site 511145002634 NADPH bind site [chemical binding]; other site 511145002635 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 511145002636 RimK-like ATP-grasp domain; Region: RimK; pfam08443 511145002637 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 511145002638 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 511145002639 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 511145002640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145002641 Walker A/P-loop; other site 511145002642 ATP binding site [chemical binding]; other site 511145002643 Q-loop/lid; other site 511145002644 ABC transporter signature motif; other site 511145002645 Walker B; other site 511145002646 D-loop; other site 511145002647 H-loop/switch region; other site 511145002648 TOBE domain; Region: TOBE_2; pfam08402 511145002649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145002650 dimer interface [polypeptide binding]; other site 511145002651 conserved gate region; other site 511145002652 putative PBP binding loops; other site 511145002653 ABC-ATPase subunit interface; other site 511145002654 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 511145002655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145002656 dimer interface [polypeptide binding]; other site 511145002657 conserved gate region; other site 511145002658 putative PBP binding loops; other site 511145002659 ABC-ATPase subunit interface; other site 511145002660 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 511145002661 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 511145002662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145002663 S-adenosylmethionine binding site [chemical binding]; other site 511145002664 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 511145002665 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145002666 substrate binding pocket [chemical binding]; other site 511145002667 membrane-bound complex binding site; other site 511145002668 hinge residues; other site 511145002669 arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122 511145002670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145002671 dimer interface [polypeptide binding]; other site 511145002672 conserved gate region; other site 511145002673 putative PBP binding loops; other site 511145002674 ABC-ATPase subunit interface; other site 511145002675 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511145002676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145002677 dimer interface [polypeptide binding]; other site 511145002678 conserved gate region; other site 511145002679 putative PBP binding loops; other site 511145002680 ABC-ATPase subunit interface; other site 511145002681 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 511145002682 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145002683 substrate binding pocket [chemical binding]; other site 511145002684 membrane-bound complex binding site; other site 511145002685 hinge residues; other site 511145002686 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 511145002687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145002688 Walker A/P-loop; other site 511145002689 ATP binding site [chemical binding]; other site 511145002690 Q-loop/lid; other site 511145002691 ABC transporter signature motif; other site 511145002692 Walker B; other site 511145002693 D-loop; other site 511145002694 H-loop/switch region; other site 511145002695 putative lipoprotein; Provisional; Region: PRK10533 511145002696 hypothetical protein; Provisional; Region: PRK02877 511145002697 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 511145002698 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511145002699 amidase catalytic site [active] 511145002700 Zn binding residues [ion binding]; other site 511145002701 substrate binding site [chemical binding]; other site 511145002702 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 511145002703 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 511145002704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511145002705 NAD(P) binding site [chemical binding]; other site 511145002706 active site 511145002707 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 511145002708 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 511145002709 putative NAD(P) binding site [chemical binding]; other site 511145002710 putative active site [active] 511145002711 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 511145002712 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 511145002713 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 511145002714 tetramer interface [polypeptide binding]; other site 511145002715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145002716 catalytic residue [active] 511145002717 pyruvate dehydrogenase; Provisional; Region: PRK09124 511145002718 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 511145002719 PYR/PP interface [polypeptide binding]; other site 511145002720 dimer interface [polypeptide binding]; other site 511145002721 tetramer interface [polypeptide binding]; other site 511145002722 TPP binding site [chemical binding]; other site 511145002723 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511145002724 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 511145002725 TPP-binding site [chemical binding]; other site 511145002726 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 511145002727 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 511145002728 FAD binding pocket [chemical binding]; other site 511145002729 FAD binding motif [chemical binding]; other site 511145002730 phosphate binding motif [ion binding]; other site 511145002731 beta-alpha-beta structure motif; other site 511145002732 NAD binding pocket [chemical binding]; other site 511145002733 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511145002734 catalytic loop [active] 511145002735 iron binding site [ion binding]; other site 511145002736 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 511145002737 cubane metal cluster [ion binding]; other site 511145002738 hybrid metal cluster; other site 511145002739 Predicted membrane protein [Function unknown]; Region: COG2431 511145002740 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 511145002741 amphipathic channel; other site 511145002742 Asn-Pro-Ala signature motifs; other site 511145002743 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 511145002744 AAA domain; Region: AAA_21; pfam13304 511145002745 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 511145002746 putative active site [active] 511145002747 putative metal-binding site [ion binding]; other site 511145002748 Protein of unknown function (DUF535); Region: DUF535; pfam04393 511145002749 macrolide transporter subunit MacA; Provisional; Region: PRK11578 511145002750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145002751 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145002752 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 511145002753 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511145002754 Walker A/P-loop; other site 511145002755 ATP binding site [chemical binding]; other site 511145002756 Q-loop/lid; other site 511145002757 ABC transporter signature motif; other site 511145002758 Walker B; other site 511145002759 D-loop; other site 511145002760 H-loop/switch region; other site 511145002761 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511145002762 FtsX-like permease family; Region: FtsX; pfam02687 511145002763 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511145002764 DNA-binding site [nucleotide binding]; DNA binding site 511145002765 RNA-binding motif; other site 511145002766 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 511145002767 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 511145002768 Clp amino terminal domain; Region: Clp_N; pfam02861 511145002769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145002770 Walker A motif; other site 511145002771 ATP binding site [chemical binding]; other site 511145002772 Walker B motif; other site 511145002773 arginine finger; other site 511145002774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145002775 Walker A motif; other site 511145002776 ATP binding site [chemical binding]; other site 511145002777 Walker B motif; other site 511145002778 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511145002779 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 511145002780 rRNA binding site [nucleotide binding]; other site 511145002781 predicted 30S ribosome binding site; other site 511145002782 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 511145002783 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 511145002784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511145002785 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 511145002786 Walker A/P-loop; other site 511145002787 ATP binding site [chemical binding]; other site 511145002788 Q-loop/lid; other site 511145002789 ABC transporter signature motif; other site 511145002790 Walker B; other site 511145002791 D-loop; other site 511145002792 H-loop/switch region; other site 511145002793 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 511145002794 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511145002795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145002796 Walker A/P-loop; other site 511145002797 ATP binding site [chemical binding]; other site 511145002798 Q-loop/lid; other site 511145002799 ABC transporter signature motif; other site 511145002800 Walker B; other site 511145002801 D-loop; other site 511145002802 H-loop/switch region; other site 511145002803 thioredoxin reductase; Provisional; Region: PRK10262 511145002804 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145002805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145002806 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 511145002807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511145002808 putative DNA binding site [nucleotide binding]; other site 511145002809 putative Zn2+ binding site [ion binding]; other site 511145002810 AsnC family; Region: AsnC_trans_reg; pfam01037 511145002811 DNA translocase FtsK; Provisional; Region: PRK10263 511145002812 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 511145002813 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 511145002814 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 511145002815 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 511145002816 periplasmic chaperone LolA; Region: lolA; TIGR00547 511145002817 recombination factor protein RarA; Reviewed; Region: PRK13342 511145002818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145002819 Walker A motif; other site 511145002820 ATP binding site [chemical binding]; other site 511145002821 Walker B motif; other site 511145002822 arginine finger; other site 511145002823 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 511145002824 seryl-tRNA synthetase; Provisional; Region: PRK05431 511145002825 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 511145002826 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 511145002827 dimer interface [polypeptide binding]; other site 511145002828 active site 511145002829 motif 1; other site 511145002830 motif 2; other site 511145002831 motif 3; other site 511145002832 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 511145002833 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 511145002834 putative [Fe4-S4] binding site [ion binding]; other site 511145002835 putative molybdopterin cofactor binding site [chemical binding]; other site 511145002836 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 511145002837 putative molybdopterin cofactor binding site; other site 511145002838 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 511145002839 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145002840 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 511145002841 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 511145002842 catalytic triad [active] 511145002843 dimer interface [polypeptide binding]; other site 511145002844 conserved cis-peptide bond; other site 511145002845 putative MFS family transporter protein; Provisional; Region: PRK03633 511145002846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145002847 putative substrate translocation pore; other site 511145002848 Amino acid permease; Region: AA_permease_2; pfam13520 511145002849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145002850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145002851 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 511145002852 putative effector binding pocket; other site 511145002853 putative dimerization interface [polypeptide binding]; other site 511145002854 hypothetical protein; Provisional; Region: PRK09739 511145002855 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 511145002856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145002857 FeS/SAM binding site; other site 511145002858 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 511145002859 Pyruvate formate lyase 1; Region: PFL1; cd01678 511145002860 coenzyme A binding site [chemical binding]; other site 511145002861 active site 511145002862 catalytic residues [active] 511145002863 glycine loop; other site 511145002864 formate transporter; Provisional; Region: PRK10805 511145002865 uncharacterized domain; Region: TIGR00702 511145002866 Predicted membrane protein [Function unknown]; Region: COG2323 511145002867 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 511145002868 homodimer interface [polypeptide binding]; other site 511145002869 substrate-cofactor binding pocket; other site 511145002870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145002871 catalytic residue [active] 511145002872 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 511145002873 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 511145002874 hinge; other site 511145002875 active site 511145002876 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 511145002877 cytidylate kinase; Provisional; Region: cmk; PRK00023 511145002878 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 511145002879 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 511145002880 active site 511145002881 CMP-binding site; other site 511145002882 The sites determining sugar specificity; other site 511145002883 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 511145002884 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 511145002885 RNA binding site [nucleotide binding]; other site 511145002886 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 511145002887 RNA binding site [nucleotide binding]; other site 511145002888 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 511145002889 RNA binding site [nucleotide binding]; other site 511145002890 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 511145002891 RNA binding site [nucleotide binding]; other site 511145002892 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 511145002893 RNA binding site [nucleotide binding]; other site 511145002894 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 511145002895 RNA binding site [nucleotide binding]; other site 511145002896 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 511145002897 dimer interface [polypeptide binding]; other site 511145002898 DNA binding site [nucleotide binding] 511145002899 ComEC family competence protein; Provisional; Region: PRK11539 511145002900 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 511145002901 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 511145002902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 511145002903 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 511145002904 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511145002905 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 511145002906 Walker A/P-loop; other site 511145002907 ATP binding site [chemical binding]; other site 511145002908 Q-loop/lid; other site 511145002909 ABC transporter signature motif; other site 511145002910 Walker B; other site 511145002911 D-loop; other site 511145002912 H-loop/switch region; other site 511145002913 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 511145002914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 511145002915 hypothetical protein; Provisional; Region: PRK11827 511145002916 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 511145002917 Ligand binding site; other site 511145002918 oligomer interface; other site 511145002919 hypothetical protein; Provisional; Region: PRK10593 511145002920 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 511145002921 putative active site [active] 511145002922 Methyltransferase domain; Region: Methyltransf_31; pfam13847 511145002923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145002924 S-adenosylmethionine binding site [chemical binding]; other site 511145002925 condesin subunit F; Provisional; Region: PRK05260 511145002926 condesin subunit E; Provisional; Region: PRK05256 511145002927 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 511145002928 MukB N-terminal; Region: MukB; pfam04310 511145002929 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 511145002930 murein L,D-transpeptidase; Provisional; Region: PRK10594 511145002931 K+ potassium transporter; Region: K_trans; cl15781 511145002932 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 511145002933 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 511145002934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 511145002935 Peptidase M15; Region: Peptidase_M15_3; cl01194 511145002936 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 511145002937 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 511145002938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145002939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145002940 homodimer interface [polypeptide binding]; other site 511145002941 catalytic residue [active] 511145002942 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 511145002943 trimer interface [polypeptide binding]; other site 511145002944 eyelet of channel; other site 511145002945 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 511145002946 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 511145002947 putative dimer interface [polypeptide binding]; other site 511145002948 putative anticodon binding site; other site 511145002949 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 511145002950 homodimer interface [polypeptide binding]; other site 511145002951 motif 1; other site 511145002952 motif 2; other site 511145002953 active site 511145002954 motif 3; other site 511145002955 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 511145002956 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 511145002957 active site 511145002958 aminopeptidase N; Provisional; Region: pepN; PRK14015 511145002959 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 511145002960 active site 511145002961 Zn binding site [ion binding]; other site 511145002962 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 511145002963 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 511145002964 Walker A/P-loop; other site 511145002965 ATP binding site [chemical binding]; other site 511145002966 Q-loop/lid; other site 511145002967 ABC transporter signature motif; other site 511145002968 Walker B; other site 511145002969 D-loop; other site 511145002970 H-loop/switch region; other site 511145002971 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 511145002972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145002973 dimer interface [polypeptide binding]; other site 511145002974 conserved gate region; other site 511145002975 putative PBP binding loops; other site 511145002976 ABC-ATPase subunit interface; other site 511145002977 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 511145002978 active site 511145002979 dimer interface [polypeptide binding]; other site 511145002980 non-prolyl cis peptide bond; other site 511145002981 insertion regions; other site 511145002982 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145002983 substrate binding pocket [chemical binding]; other site 511145002984 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 511145002985 membrane-bound complex binding site; other site 511145002986 hinge residues; other site 511145002987 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 511145002988 Fimbrial protein; Region: Fimbrial; cl01416 511145002989 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 511145002990 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145002991 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145002992 outer membrane usher protein; Provisional; Region: PRK15193 511145002993 PapC N-terminal domain; Region: PapC_N; pfam13954 511145002994 Outer membrane usher protein; Region: Usher; pfam00577 511145002995 PapC C-terminal domain; Region: PapC_C; pfam13953 511145002996 Fimbrial protein; Region: Fimbrial; cl01416 511145002997 Fimbrial protein; Region: Fimbrial; cl01416 511145002998 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 511145002999 putativi pili assembly chaperone; Provisional; Region: PRK11385 511145003000 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145003001 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145003002 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 511145003003 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 511145003004 quinone interaction residues [chemical binding]; other site 511145003005 active site 511145003006 catalytic residues [active] 511145003007 FMN binding site [chemical binding]; other site 511145003008 substrate binding site [chemical binding]; other site 511145003009 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 511145003010 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 511145003011 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 511145003012 MOSC domain; Region: MOSC; pfam03473 511145003013 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511145003014 catalytic loop [active] 511145003015 iron binding site [ion binding]; other site 511145003016 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 511145003017 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 511145003018 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 511145003019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145003020 S-adenosylmethionine binding site [chemical binding]; other site 511145003021 ABC transporter ATPase component; Reviewed; Region: PRK11147 511145003022 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511145003023 ABC transporter; Region: ABC_tran_2; pfam12848 511145003024 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511145003025 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 511145003026 Paraquat-inducible protein A; Region: PqiA; pfam04403 511145003027 Paraquat-inducible protein A; Region: PqiA; pfam04403 511145003028 paraquat-inducible protein B; Provisional; Region: PRK10807 511145003029 mce related protein; Region: MCE; pfam02470 511145003030 mce related protein; Region: MCE; pfam02470 511145003031 mce related protein; Region: MCE; pfam02470 511145003032 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 511145003033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 511145003034 ribosome modulation factor; Provisional; Region: PRK14563 511145003035 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 511145003036 active site 1 [active] 511145003037 dimer interface [polypeptide binding]; other site 511145003038 active site 2 [active] 511145003039 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 511145003040 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 511145003041 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 511145003042 outer membrane protein A; Reviewed; Region: PRK10808 511145003043 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 511145003044 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 511145003045 ligand binding site [chemical binding]; other site 511145003046 cell division inhibitor SulA; Region: sula; TIGR00623 511145003047 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 511145003048 TfoX C-terminal domain; Region: TfoX_C; pfam04994 511145003049 TIGR01666 family membrane protein; Region: YCCS 511145003050 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 511145003051 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 511145003052 Predicted membrane protein [Function unknown]; Region: COG3304 511145003053 Domain of unknown function (DUF307); Region: DUF307; pfam03733 511145003054 Domain of unknown function (DUF307); Region: DUF307; pfam03733 511145003055 DNA helicase IV; Provisional; Region: helD; PRK11054 511145003056 DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462 511145003057 Part of AAA domain; Region: AAA_19; pfam13245 511145003058 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 511145003059 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 511145003060 active site 511145003061 dimer interfaces [polypeptide binding]; other site 511145003062 catalytic residues [active] 511145003063 hypothetical protein; Provisional; Region: PRK03641 511145003064 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 511145003065 heat shock protein HspQ; Provisional; Region: PRK14129 511145003066 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 511145003067 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 511145003068 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 511145003069 putative RNA binding site [nucleotide binding]; other site 511145003070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145003071 S-adenosylmethionine binding site [chemical binding]; other site 511145003072 Acylphosphatase; Region: Acylphosphatase; cl00551 511145003073 sulfur transfer protein TusE; Provisional; Region: PRK11508 511145003074 YccA-like proteins; Region: YccA_like; cd10433 511145003075 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 511145003076 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 511145003077 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 511145003078 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 511145003079 hydrogenase 1 large subunit; Provisional; Region: PRK10170 511145003080 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 511145003081 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 511145003082 putative substrate-binding site; other site 511145003083 nickel binding site [ion binding]; other site 511145003084 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 511145003085 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 511145003086 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 511145003087 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 511145003088 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 511145003089 hypothetical protein; Provisional; Region: PRK14749 511145003090 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 511145003091 catalytic core [active] 511145003092 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 511145003093 Chain length determinant protein; Region: Wzz; pfam02706 511145003094 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 511145003095 AAA domain; Region: AAA_31; pfam13614 511145003096 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511145003097 active site 511145003098 polysaccharide export protein Wza; Provisional; Region: PRK15078 511145003099 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 511145003100 SLBB domain; Region: SLBB; pfam10531 511145003101 SLBB domain; Region: SLBB; pfam10531 511145003102 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 511145003103 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 511145003104 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 511145003105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 511145003106 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 511145003107 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 511145003108 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 511145003109 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511145003110 DNA-binding site [nucleotide binding]; DNA binding site 511145003111 RNA-binding motif; other site 511145003112 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511145003113 DNA-binding site [nucleotide binding]; DNA binding site 511145003114 RNA-binding motif; other site 511145003115 cold shock gene; Provisional; Region: PRK09891 511145003116 GnsA/GnsB family; Region: GnsAB; pfam08178 511145003117 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 511145003118 4Fe-4S binding domain; Region: Fer4_5; pfam12801 511145003119 4Fe-4S binding domain; Region: Fer4_5; pfam12801 511145003120 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145003121 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 511145003122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145003123 dimerization interface [polypeptide binding]; other site 511145003124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145003125 dimer interface [polypeptide binding]; other site 511145003126 phosphorylation site [posttranslational modification] 511145003127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145003128 ATP binding site [chemical binding]; other site 511145003129 Mg2+ binding site [ion binding]; other site 511145003130 G-X-G motif; other site 511145003131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145003132 active site 511145003133 phosphorylation site [posttranslational modification] 511145003134 intermolecular recognition site; other site 511145003135 dimerization interface [polypeptide binding]; other site 511145003136 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 511145003137 putative binding surface; other site 511145003138 active site 511145003139 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 511145003140 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 511145003141 putative ligand binding site [chemical binding]; other site 511145003142 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 511145003143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145003144 active site 511145003145 phosphorylation site [posttranslational modification] 511145003146 intermolecular recognition site; other site 511145003147 dimerization interface [polypeptide binding]; other site 511145003148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145003149 DNA binding site [nucleotide binding] 511145003150 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 511145003151 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 511145003152 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 511145003153 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 511145003154 molybdopterin cofactor binding site [chemical binding]; other site 511145003155 substrate binding site [chemical binding]; other site 511145003156 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 511145003157 molybdopterin cofactor binding site; other site 511145003158 chaperone protein TorD; Validated; Region: torD; PRK04976 511145003159 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 511145003160 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 511145003161 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511145003162 HSP70 interaction site [polypeptide binding]; other site 511145003163 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 511145003164 substrate binding site [polypeptide binding]; other site 511145003165 dimer interface [polypeptide binding]; other site 511145003166 hypothetical protein; Provisional; Region: PRK09784 511145003167 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 511145003168 catalytic core [active] 511145003169 hypothetical protein; Provisional; Region: PRK10174 511145003170 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 511145003171 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 511145003172 General stress protein [General function prediction only]; Region: GsiB; COG3729 511145003173 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 511145003174 uracil-xanthine permease; Region: ncs2; TIGR00801 511145003175 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 511145003176 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 511145003177 putative FMN binding site [chemical binding]; other site 511145003178 pyrimidine utilization protein D; Region: RutD; TIGR03611 511145003179 Putative lysophospholipase; Region: Hydrolase_4; cl19140 511145003180 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 511145003181 homotrimer interaction site [polypeptide binding]; other site 511145003182 putative active site [active] 511145003183 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511145003184 catalytic triad [active] 511145003185 conserved cis-peptide bond; other site 511145003186 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 511145003187 active site 511145003188 dimer interface [polypeptide binding]; other site 511145003189 non-prolyl cis peptide bond; other site 511145003190 insertion regions; other site 511145003191 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 511145003192 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 511145003193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145003194 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 511145003195 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 511145003196 Predicted transcriptional regulator [Transcription]; Region: COG3905 511145003197 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 511145003198 Proline dehydrogenase; Region: Pro_dh; pfam01619 511145003199 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 511145003200 Glutamate binding site [chemical binding]; other site 511145003201 NAD binding site [chemical binding]; other site 511145003202 catalytic residues [active] 511145003203 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 511145003204 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 511145003205 Na binding site [ion binding]; other site 511145003206 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 511145003207 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 511145003208 Imelysin; Region: Peptidase_M75; pfam09375 511145003209 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 511145003210 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 511145003211 hypothetical protein; Provisional; Region: PRK10536 511145003212 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 511145003213 N-glycosyltransferase; Provisional; Region: PRK11204 511145003214 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511145003215 DXD motif; other site 511145003216 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 511145003217 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 511145003218 putative active site [active] 511145003219 putative metal binding site [ion binding]; other site 511145003220 Hypothetical glycosyl hydrolase family 13; Region: GHL13; pfam14883 511145003221 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 511145003222 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145003223 metal binding site [ion binding]; metal-binding site 511145003224 active site 511145003225 I-site; other site 511145003226 putative transposase OrfB; Reviewed; Region: PHA02517 511145003227 HTH-like domain; Region: HTH_21; pfam13276 511145003228 Integrase core domain; Region: rve; pfam00665 511145003229 Integrase core domain; Region: rve_2; pfam13333 511145003230 Transposase; Region: HTH_Tnp_1; cl17663 511145003231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145003232 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511145003233 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 511145003234 putative ligand binding site [chemical binding]; other site 511145003235 NAD binding site [chemical binding]; other site 511145003236 dimerization interface [polypeptide binding]; other site 511145003237 catalytic site [active] 511145003238 putative hydrolase; Validated; Region: PRK09248 511145003239 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 511145003240 active site 511145003241 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 511145003242 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 511145003243 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 511145003244 curli assembly protein CsgF; Provisional; Region: PRK10050 511145003245 curli assembly protein CsgE; Provisional; Region: PRK10386 511145003246 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 511145003247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145003248 DNA binding residues [nucleotide binding] 511145003249 dimerization interface [polypeptide binding]; other site 511145003250 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 511145003251 Curlin associated repeat; Region: Curlin_rpt; pfam07012 511145003252 Curlin associated repeat; Region: Curlin_rpt; pfam07012 511145003253 major curlin subunit; Provisional; Region: csgA; PRK10051 511145003254 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; pfam10610 511145003255 Fimbrial protein; Region: Fimbrial; cl01416 511145003256 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 511145003257 putative ADP-ribose binding site [chemical binding]; other site 511145003258 putative active site [active] 511145003259 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 511145003260 PLD-like domain; Region: PLDc_2; pfam13091 511145003261 putative active site [active] 511145003262 catalytic site [active] 511145003263 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 511145003264 PLD-like domain; Region: PLDc_2; pfam13091 511145003265 putative active site [active] 511145003266 catalytic site [active] 511145003267 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 511145003268 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 511145003269 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 511145003270 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 511145003271 Ligand binding site; other site 511145003272 DXD motif; other site 511145003273 lipoprotein; Provisional; Region: PRK10175 511145003274 secY/secA suppressor protein; Provisional; Region: PRK11467 511145003275 drug efflux system protein MdtG; Provisional; Region: PRK09874 511145003276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145003277 putative substrate translocation pore; other site 511145003278 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 511145003279 putative acyl-acceptor binding pocket; other site 511145003280 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 511145003281 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 511145003282 active site residue [active] 511145003283 hypothetical protein; Provisional; Region: PRK03757 511145003284 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 511145003285 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 511145003286 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 511145003287 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 511145003288 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 511145003289 DNA damage-inducible protein I; Provisional; Region: PRK10597 511145003290 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 511145003291 active site 511145003292 substrate binding pocket [chemical binding]; other site 511145003293 dimer interface [polypeptide binding]; other site 511145003294 lipoprotein; Provisional; Region: PRK10598 511145003295 glutaredoxin 2; Provisional; Region: PRK10387 511145003296 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 511145003297 C-terminal domain interface [polypeptide binding]; other site 511145003298 GSH binding site (G-site) [chemical binding]; other site 511145003299 catalytic residues [active] 511145003300 putative dimer interface [polypeptide binding]; other site 511145003301 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 511145003302 N-terminal domain interface [polypeptide binding]; other site 511145003303 multidrug resistance protein MdtH; Provisional; Region: PRK11646 511145003304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145003305 putative substrate translocation pore; other site 511145003306 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 511145003307 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511145003308 hypothetical protein; Provisional; Region: PRK11239 511145003309 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 511145003310 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 511145003311 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 511145003312 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 511145003313 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 511145003314 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 511145003315 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 511145003316 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 511145003317 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 511145003318 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 511145003319 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 511145003320 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 511145003321 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 511145003322 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 511145003323 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 511145003324 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 511145003325 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 511145003326 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 511145003327 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 511145003328 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 511145003329 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 511145003330 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 511145003331 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 511145003332 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 511145003333 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 511145003334 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 511145003335 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 511145003336 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 511145003337 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 511145003338 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 511145003339 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 511145003340 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 511145003341 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 511145003342 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 511145003343 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 511145003344 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 511145003345 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 511145003346 ribonuclease E; Reviewed; Region: rne; PRK10811 511145003347 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 511145003348 homodimer interface [polypeptide binding]; other site 511145003349 oligonucleotide binding site [chemical binding]; other site 511145003350 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 511145003351 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 511145003352 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 511145003353 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 511145003354 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511145003355 RNA binding surface [nucleotide binding]; other site 511145003356 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511145003357 active site 511145003358 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 511145003359 active site 511145003360 dimer interface [polypeptide binding]; other site 511145003361 hypothetical protein; Provisional; Region: PRK11193 511145003362 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 511145003363 putative phosphate acyltransferase; Provisional; Region: PRK05331 511145003364 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 511145003365 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 511145003366 dimer interface [polypeptide binding]; other site 511145003367 active site 511145003368 CoA binding pocket [chemical binding]; other site 511145003369 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 511145003370 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 511145003371 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 511145003372 NAD(P) binding site [chemical binding]; other site 511145003373 homotetramer interface [polypeptide binding]; other site 511145003374 homodimer interface [polypeptide binding]; other site 511145003375 active site 511145003376 acyl carrier protein; Provisional; Region: acpP; PRK00982 511145003377 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 511145003378 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 511145003379 dimer interface [polypeptide binding]; other site 511145003380 active site 511145003381 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 511145003382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145003383 catalytic residue [active] 511145003384 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 511145003385 dimerization interface [polypeptide binding]; other site 511145003386 thymidylate kinase; Validated; Region: tmk; PRK00698 511145003387 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 511145003388 TMP-binding site; other site 511145003389 ATP-binding site [chemical binding]; other site 511145003390 DNA polymerase III subunit delta'; Validated; Region: PRK07993 511145003391 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 511145003392 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 511145003393 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 511145003394 active site 511145003395 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 511145003396 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511145003397 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511145003398 active site turn [active] 511145003399 phosphorylation site [posttranslational modification] 511145003400 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 511145003401 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 511145003402 N-terminal plug; other site 511145003403 ligand-binding site [chemical binding]; other site 511145003404 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 511145003405 nucleotide binding site/active site [active] 511145003406 HIT family signature motif; other site 511145003407 catalytic residue [active] 511145003408 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 511145003409 putative dimer interface [polypeptide binding]; other site 511145003410 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 511145003411 thiamine kinase; Region: ycfN_thiK; TIGR02721 511145003412 Phosphotransferase enzyme family; Region: APH; pfam01636 511145003413 active site 511145003414 substrate binding site [chemical binding]; other site 511145003415 ATP binding site [chemical binding]; other site 511145003416 beta-hexosaminidase; Provisional; Region: PRK05337 511145003417 hypothetical protein; Provisional; Region: PRK04940 511145003418 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 511145003419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145003420 hypothetical protein; Provisional; Region: PRK11280 511145003421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511145003422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145003423 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 511145003424 L,D-transpeptidase; Provisional; Region: PRK10260 511145003425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511145003426 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 511145003427 transcription-repair coupling factor; Provisional; Region: PRK10689 511145003428 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 511145003429 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 511145003430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145003431 ATP binding site [chemical binding]; other site 511145003432 putative Mg++ binding site [ion binding]; other site 511145003433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145003434 nucleotide binding region [chemical binding]; other site 511145003435 ATP-binding site [chemical binding]; other site 511145003436 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 511145003437 Predicted membrane protein [Function unknown]; Region: COG4763 511145003438 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 511145003439 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511145003440 FtsX-like permease family; Region: FtsX; pfam02687 511145003441 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 511145003442 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511145003443 Walker A/P-loop; other site 511145003444 ATP binding site [chemical binding]; other site 511145003445 Q-loop/lid; other site 511145003446 ABC transporter signature motif; other site 511145003447 Walker B; other site 511145003448 D-loop; other site 511145003449 H-loop/switch region; other site 511145003450 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 511145003451 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511145003452 FtsX-like permease family; Region: FtsX; pfam02687 511145003453 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511145003454 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145003455 nucleotide binding site [chemical binding]; other site 511145003456 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 511145003457 NAD+ binding site [chemical binding]; other site 511145003458 substrate binding site [chemical binding]; other site 511145003459 Zn binding site [ion binding]; other site 511145003460 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 511145003461 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 511145003462 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 511145003463 spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500 511145003464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145003465 dimer interface [polypeptide binding]; other site 511145003466 conserved gate region; other site 511145003467 putative PBP binding loops; other site 511145003468 ABC-ATPase subunit interface; other site 511145003469 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 511145003470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145003471 dimer interface [polypeptide binding]; other site 511145003472 conserved gate region; other site 511145003473 putative PBP binding loops; other site 511145003474 ABC-ATPase subunit interface; other site 511145003475 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 511145003476 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 511145003477 Walker A/P-loop; other site 511145003478 ATP binding site [chemical binding]; other site 511145003479 Q-loop/lid; other site 511145003480 ABC transporter signature motif; other site 511145003481 Walker B; other site 511145003482 D-loop; other site 511145003483 H-loop/switch region; other site 511145003484 TOBE domain; Region: TOBE_2; pfam08402 511145003485 peptidase T-like protein; Region: PepT-like; TIGR01883 511145003486 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 511145003487 metal binding site [ion binding]; metal-binding site 511145003488 dimer interface [polypeptide binding]; other site 511145003489 Uncharacterized conserved protein [Function unknown]; Region: COG2850 511145003490 sensor protein PhoQ; Provisional; Region: PRK10815 511145003491 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 511145003492 HAMP domain; Region: HAMP; pfam00672 511145003493 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 511145003494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145003495 ATP binding site [chemical binding]; other site 511145003496 Mg2+ binding site [ion binding]; other site 511145003497 G-X-G motif; other site 511145003498 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 511145003499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145003500 active site 511145003501 phosphorylation site [posttranslational modification] 511145003502 intermolecular recognition site; other site 511145003503 dimerization interface [polypeptide binding]; other site 511145003504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145003505 DNA binding site [nucleotide binding] 511145003506 adenylosuccinate lyase; Provisional; Region: PRK09285 511145003507 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 511145003508 tetramer interface [polypeptide binding]; other site 511145003509 active site 511145003510 putative lysogenization regulator; Reviewed; Region: PRK00218 511145003511 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 511145003512 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 511145003513 Ligand Binding Site [chemical binding]; other site 511145003514 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 511145003515 nudix motif; other site 511145003516 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 511145003517 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 511145003518 probable active site [active] 511145003519 isocitrate dehydrogenase; Reviewed; Region: PRK07006 511145003520 cryptic prophage e14 511145003521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145003522 S-adenosylmethionine binding site [chemical binding]; other site 511145003523 phage exclusion protein Lit; Provisional; Region: PRK09672 511145003524 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 511145003525 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 511145003526 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 511145003527 dimer interface [polypeptide binding]; other site 511145003528 active site 511145003529 Int/Topo IB signature motif; other site 511145003530 Excisionase-like protein; Region: Exc; pfam07825 511145003531 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 511145003532 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511145003533 Catalytic site [active] 511145003534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 511145003535 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 511145003536 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 511145003537 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 511145003538 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511145003539 catalytic residues [active] 511145003540 catalytic nucleophile [active] 511145003541 Presynaptic Site I dimer interface [polypeptide binding]; other site 511145003542 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511145003543 Synaptic Flat tetramer interface [polypeptide binding]; other site 511145003544 Synaptic Site I dimer interface [polypeptide binding]; other site 511145003545 DNA binding site [nucleotide binding] 511145003546 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 511145003547 DNA-binding interface [nucleotide binding]; DNA binding site 511145003548 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 511145003549 active site 511145003550 anti-adapter protein IraM; Provisional; Region: PRK09919 511145003551 Phage envelope protein [General function prediction only]; Region: COG5562 511145003552 transcriptional regulator MirA; Provisional; Region: PRK15043 511145003553 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 511145003554 DNA binding residues [nucleotide binding] 511145003555 Sensors of blue-light using FAD; Region: BLUF; smart01034 511145003556 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145003557 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 511145003558 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 511145003559 phage resistance protein; Provisional; Region: PRK10551 511145003560 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 511145003561 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145003562 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 511145003563 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 511145003564 cell division inhibitor MinD; Provisional; Region: PRK10818 511145003565 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 511145003566 P-loop; other site 511145003567 ADP binding residues [chemical binding]; other site 511145003568 Switch I; other site 511145003569 Switch II; other site 511145003570 septum formation inhibitor; Reviewed; Region: minC; PRK03511 511145003571 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 511145003572 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 511145003573 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 511145003574 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 511145003575 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 511145003576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 511145003577 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 511145003578 hypothetical protein; Provisional; Region: PRK10691 511145003579 hypothetical protein; Provisional; Region: PRK05170 511145003580 Haemolysin E (HlyE); Region: HlyE; pfam06109 511145003581 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 511145003582 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511145003583 Catalytic site [active] 511145003584 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 511145003585 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 511145003586 active site 511145003587 DNA binding site [nucleotide binding] 511145003588 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 511145003589 disulfide bond formation protein B; Provisional; Region: PRK01749 511145003590 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 511145003591 fatty acid metabolism regulator; Provisional; Region: PRK04984 511145003592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145003593 DNA-binding site [nucleotide binding]; DNA binding site 511145003594 FadR C-terminal domain; Region: FadR_C; pfam07840 511145003595 SpoVR family protein; Provisional; Region: PRK11767 511145003596 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 511145003597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145003598 alanine racemase; Reviewed; Region: dadX; PRK03646 511145003599 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 511145003600 active site 511145003601 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511145003602 substrate binding site [chemical binding]; other site 511145003603 catalytic residues [active] 511145003604 dimer interface [polypeptide binding]; other site 511145003605 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 511145003606 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 511145003607 TrkA-C domain; Region: TrkA_C; pfam02080 511145003608 Transporter associated domain; Region: CorC_HlyC; smart01091 511145003609 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 511145003610 dimer interface [polypeptide binding]; other site 511145003611 catalytic triad [active] 511145003612 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 511145003613 N-acetyl-D-glucosamine binding site [chemical binding]; other site 511145003614 catalytic residue [active] 511145003615 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 511145003616 Flagellar regulator YcgR; Region: YcgR; pfam07317 511145003617 PilZ domain; Region: PilZ; pfam07238 511145003618 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 511145003619 trehalase; Provisional; Region: treA; PRK13271 511145003620 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 511145003621 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 511145003622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 511145003623 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511145003624 dimerization domain swap beta strand [polypeptide binding]; other site 511145003625 regulatory protein interface [polypeptide binding]; other site 511145003626 active site 511145003627 regulatory phosphorylation site [posttranslational modification]; other site 511145003628 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 511145003629 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511145003630 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 511145003631 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 511145003632 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 511145003633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145003634 putative active site [active] 511145003635 heme pocket [chemical binding]; other site 511145003636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145003637 Walker A motif; other site 511145003638 ATP binding site [chemical binding]; other site 511145003639 Walker B motif; other site 511145003640 arginine finger; other site 511145003641 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511145003642 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 511145003643 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 511145003644 Autotransporter beta-domain; Region: Autotransporter; pfam03797 511145003645 GTP-binding protein YchF; Reviewed; Region: PRK09601 511145003646 YchF GTPase; Region: YchF; cd01900 511145003647 G1 box; other site 511145003648 GTP/Mg2+ binding site [chemical binding]; other site 511145003649 Switch I region; other site 511145003650 G2 box; other site 511145003651 Switch II region; other site 511145003652 G3 box; other site 511145003653 G4 box; other site 511145003654 G5 box; other site 511145003655 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 511145003656 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 511145003657 putative active site [active] 511145003658 catalytic residue [active] 511145003659 hypothetical protein; Provisional; Region: PRK10692 511145003660 putative transporter; Provisional; Region: PRK11660 511145003661 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 511145003662 Sulfate transporter family; Region: Sulfate_transp; pfam00916 511145003663 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 511145003664 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 511145003665 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511145003666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511145003667 active site 511145003668 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 511145003669 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511145003670 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511145003671 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 511145003672 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 511145003673 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 511145003674 tRNA; other site 511145003675 putative tRNA binding site [nucleotide binding]; other site 511145003676 putative NADP binding site [chemical binding]; other site 511145003677 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 511145003678 peptide chain release factor 1; Validated; Region: prfA; PRK00591 511145003679 This domain is found in peptide chain release factors; Region: PCRF; smart00937 511145003680 RF-1 domain; Region: RF-1; pfam00472 511145003681 HemK family putative methylases; Region: hemK_fam; TIGR00536 511145003682 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; cl17726 511145003683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145003684 S-adenosylmethionine binding site [chemical binding]; other site 511145003685 hypothetical protein; Provisional; Region: PRK10278 511145003686 hypothetical protein; Provisional; Region: PRK10941 511145003687 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 511145003688 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 511145003689 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 511145003690 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 511145003691 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 511145003692 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 511145003693 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 511145003694 cation transport regulator; Reviewed; Region: chaB; PRK09582 511145003695 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 511145003696 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 511145003697 putative active site pocket [active] 511145003698 dimerization interface [polypeptide binding]; other site 511145003699 putative catalytic residue [active] 511145003700 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 511145003701 putative invasin; Provisional; Region: PRK10177 511145003702 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 511145003703 transcriptional regulator NarL; Provisional; Region: PRK10651 511145003704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145003705 active site 511145003706 phosphorylation site [posttranslational modification] 511145003707 intermolecular recognition site; other site 511145003708 dimerization interface [polypeptide binding]; other site 511145003709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145003710 DNA binding residues [nucleotide binding] 511145003711 dimerization interface [polypeptide binding]; other site 511145003712 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 511145003713 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 511145003714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145003715 dimerization interface [polypeptide binding]; other site 511145003716 Histidine kinase; Region: HisKA_3; pfam07730 511145003717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145003718 ATP binding site [chemical binding]; other site 511145003719 Mg2+ binding site [ion binding]; other site 511145003720 G-X-G motif; other site 511145003721 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 511145003722 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 511145003723 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 511145003724 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 511145003725 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 511145003726 [4Fe-4S] binding site [ion binding]; other site 511145003727 molybdopterin cofactor binding site [chemical binding]; other site 511145003728 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 511145003729 molybdopterin cofactor binding site; other site 511145003730 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 511145003731 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145003732 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 511145003733 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 511145003734 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 511145003735 putative protamine-like protein; Provisional; Region: PRK14757 511145003736 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 511145003737 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 511145003738 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 511145003739 putative active site [active] 511145003740 putative substrate binding site [chemical binding]; other site 511145003741 putative cosubstrate binding site; other site 511145003742 catalytic site [active] 511145003743 hypothetical protein; Provisional; Region: PRK01617 511145003744 SEC-C motif; Region: SEC-C; cl19389 511145003745 SEC-C motif; Region: SEC-C; cl19389 511145003746 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 511145003747 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 511145003748 active site 511145003749 nucleophile elbow; other site 511145003750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145003751 active site 511145003752 response regulator of RpoS; Provisional; Region: PRK10693 511145003753 phosphorylation site [posttranslational modification] 511145003754 intermolecular recognition site; other site 511145003755 dimerization interface [polypeptide binding]; other site 511145003756 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 511145003757 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 511145003758 active site 511145003759 tetramer interface; other site 511145003760 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 511145003761 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 511145003762 thymidine kinase; Provisional; Region: PRK04296 511145003763 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 511145003764 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 511145003765 putative catalytic cysteine [active] 511145003766 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 511145003767 putative active site [active] 511145003768 metal binding site [ion binding]; metal-binding site 511145003769 hypothetical protein; Provisional; Region: PRK11111 511145003770 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511145003771 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511145003772 peptide binding site [polypeptide binding]; other site 511145003773 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 511145003774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145003775 dimer interface [polypeptide binding]; other site 511145003776 conserved gate region; other site 511145003777 putative PBP binding loops; other site 511145003778 ABC-ATPase subunit interface; other site 511145003779 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 511145003780 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 511145003781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145003782 dimer interface [polypeptide binding]; other site 511145003783 conserved gate region; other site 511145003784 putative PBP binding loops; other site 511145003785 ABC-ATPase subunit interface; other site 511145003786 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 511145003787 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145003788 Walker A/P-loop; other site 511145003789 ATP binding site [chemical binding]; other site 511145003790 Q-loop/lid; other site 511145003791 ABC transporter signature motif; other site 511145003792 Walker B; other site 511145003793 D-loop; other site 511145003794 H-loop/switch region; other site 511145003795 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511145003796 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 511145003797 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145003798 Walker A/P-loop; other site 511145003799 ATP binding site [chemical binding]; other site 511145003800 Q-loop/lid; other site 511145003801 ABC transporter signature motif; other site 511145003802 Walker B; other site 511145003803 D-loop; other site 511145003804 H-loop/switch region; other site 511145003805 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511145003806 dsDNA-mimic protein; Reviewed; Region: PRK05094 511145003807 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 511145003808 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 511145003809 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 511145003810 putative active site [active] 511145003811 catalytic site [active] 511145003812 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 511145003813 putative active site [active] 511145003814 catalytic site [active] 511145003815 voltage-gated potassium channel; Provisional; Region: PRK10537 511145003816 Ion channel; Region: Ion_trans_2; pfam07885 511145003817 TrkA-N domain; Region: TrkA_N; pfam02254 511145003818 YciI-like protein; Reviewed; Region: PRK11370 511145003819 transport protein TonB; Provisional; Region: PRK10819 511145003820 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 511145003821 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 511145003822 intracellular septation protein A; Reviewed; Region: PRK00259 511145003823 hypothetical protein; Provisional; Region: PRK02868 511145003824 outer membrane protein W; Provisional; Region: PRK10959 511145003825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 511145003826 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 511145003827 dimerization interface [polypeptide binding]; other site 511145003828 metal binding site [ion binding]; metal-binding site 511145003829 General stress protein [General function prediction only]; Region: GsiB; COG3729 511145003830 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 511145003831 substrate binding site [chemical binding]; other site 511145003832 active site 511145003833 catalytic residues [active] 511145003834 heterodimer interface [polypeptide binding]; other site 511145003835 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 511145003836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145003837 catalytic residue [active] 511145003838 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 511145003839 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 511145003840 glutamine binding [chemical binding]; other site 511145003841 catalytic triad [active] 511145003842 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511145003843 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511145003844 anthranilate synthase component I; Provisional; Region: PRK13564 511145003845 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 511145003846 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 511145003847 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 511145003848 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 511145003849 active site 511145003850 hypothetical protein; Provisional; Region: PRK11630 511145003851 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 511145003852 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 511145003853 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511145003854 RNA binding surface [nucleotide binding]; other site 511145003855 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 511145003856 probable active site [active] 511145003857 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 511145003858 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 511145003859 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 511145003860 homodimer interface [polypeptide binding]; other site 511145003861 Walker A motif; other site 511145003862 ATP binding site [chemical binding]; other site 511145003863 hydroxycobalamin binding site [chemical binding]; other site 511145003864 Walker B motif; other site 511145003865 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 511145003866 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 511145003867 NADP binding site [chemical binding]; other site 511145003868 homodimer interface [polypeptide binding]; other site 511145003869 active site 511145003870 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 511145003871 putative inner membrane peptidase; Provisional; Region: PRK11778 511145003872 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 511145003873 tandem repeat interface [polypeptide binding]; other site 511145003874 oligomer interface [polypeptide binding]; other site 511145003875 active site residues [active] 511145003876 hypothetical protein; Provisional; Region: PRK11037 511145003877 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 511145003878 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 511145003879 active site 511145003880 interdomain interaction site; other site 511145003881 putative metal-binding site [ion binding]; other site 511145003882 nucleotide binding site [chemical binding]; other site 511145003883 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511145003884 domain I; other site 511145003885 DNA binding groove [nucleotide binding] 511145003886 phosphate binding site [ion binding]; other site 511145003887 domain II; other site 511145003888 domain III; other site 511145003889 nucleotide binding site [chemical binding]; other site 511145003890 catalytic site [active] 511145003891 domain IV; other site 511145003892 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511145003893 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511145003894 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 511145003895 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 511145003896 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 511145003897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145003898 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 511145003899 substrate binding site [chemical binding]; other site 511145003900 putative dimerization interface [polypeptide binding]; other site 511145003901 aconitate hydratase; Validated; Region: PRK09277 511145003902 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 511145003903 substrate binding site [chemical binding]; other site 511145003904 ligand binding site [chemical binding]; other site 511145003905 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 511145003906 substrate binding site [chemical binding]; other site 511145003907 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 511145003908 dimerization interface [polypeptide binding]; other site 511145003909 active site 511145003910 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 511145003911 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 511145003912 active site 511145003913 Predicted membrane protein [Function unknown]; Region: COG3771 511145003914 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 511145003915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145003916 TPR motif; other site 511145003917 binding surface 511145003918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145003919 binding surface 511145003920 TPR motif; other site 511145003921 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 511145003922 active site 511145003923 dimer interface [polypeptide binding]; other site 511145003924 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 511145003925 putative rRNA binding site [nucleotide binding]; other site 511145003926 lipoprotein; Provisional; Region: PRK10540 511145003927 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511145003928 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 511145003929 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145003930 hypothetical protein; Provisional; Region: PRK13658 511145003931 RNase II stability modulator; Provisional; Region: PRK10060 511145003932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145003933 putative active site [active] 511145003934 heme pocket [chemical binding]; other site 511145003935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145003936 metal binding site [ion binding]; metal-binding site 511145003937 active site 511145003938 I-site; other site 511145003939 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145003940 exoribonuclease II; Provisional; Region: PRK05054 511145003941 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 511145003942 RNB domain; Region: RNB; pfam00773 511145003943 S1 RNA binding domain; Region: S1; pfam00575 511145003944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 511145003945 Uncharacterized conserved protein [Function unknown]; Region: COG2128 511145003946 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 511145003947 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 511145003948 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 511145003949 NAD binding site [chemical binding]; other site 511145003950 homotetramer interface [polypeptide binding]; other site 511145003951 homodimer interface [polypeptide binding]; other site 511145003952 substrate binding site [chemical binding]; other site 511145003953 active site 511145003954 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 511145003955 putative active site [active] 511145003956 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 511145003957 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145003958 Walker A/P-loop; other site 511145003959 ATP binding site [chemical binding]; other site 511145003960 Q-loop/lid; other site 511145003961 ABC transporter signature motif; other site 511145003962 Walker B; other site 511145003963 D-loop; other site 511145003964 H-loop/switch region; other site 511145003965 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 511145003966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145003967 Walker A/P-loop; other site 511145003968 ATP binding site [chemical binding]; other site 511145003969 Q-loop/lid; other site 511145003970 ABC transporter signature motif; other site 511145003971 Walker B; other site 511145003972 D-loop; other site 511145003973 H-loop/switch region; other site 511145003974 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511145003975 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 511145003976 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 511145003977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145003978 dimer interface [polypeptide binding]; other site 511145003979 conserved gate region; other site 511145003980 putative PBP binding loops; other site 511145003981 ABC-ATPase subunit interface; other site 511145003982 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 511145003983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145003984 dimer interface [polypeptide binding]; other site 511145003985 conserved gate region; other site 511145003986 putative PBP binding loops; other site 511145003987 ABC-ATPase subunit interface; other site 511145003988 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 511145003989 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 511145003990 peptide binding site [polypeptide binding]; other site 511145003991 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 511145003992 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145003993 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 511145003994 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 511145003995 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 511145003996 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 511145003997 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 511145003998 catalytic triad [active] 511145003999 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 511145004000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145004001 non-specific DNA binding site [nucleotide binding]; other site 511145004002 salt bridge; other site 511145004003 sequence-specific DNA binding site [nucleotide binding]; other site 511145004004 Cupin domain; Region: Cupin_2; pfam07883 511145004005 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 511145004006 NAD(P) binding site [chemical binding]; other site 511145004007 catalytic residues [active] 511145004008 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 511145004009 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 511145004010 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511145004011 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 511145004012 inhibitor-cofactor binding pocket; inhibition site 511145004013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145004014 catalytic residue [active] 511145004015 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 511145004016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145004017 Walker A motif; other site 511145004018 ATP binding site [chemical binding]; other site 511145004019 Walker B motif; other site 511145004020 arginine finger; other site 511145004021 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 511145004022 phage shock protein PspA; Provisional; Region: PRK10698 511145004023 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 511145004024 phage shock protein B; Provisional; Region: pspB; PRK09458 511145004025 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 511145004026 phage shock protein C; Region: phageshock_pspC; TIGR02978 511145004027 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 511145004028 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511145004029 active site residue [active] 511145004030 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 511145004031 sucrose phosphorylase; Provisional; Region: PRK13840 511145004032 active site 511145004033 homodimer interface [polypeptide binding]; other site 511145004034 catalytic site [active] 511145004035 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511145004036 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 511145004037 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 511145004038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145004039 dimer interface [polypeptide binding]; other site 511145004040 conserved gate region; other site 511145004041 putative PBP binding loops; other site 511145004042 ABC-ATPase subunit interface; other site 511145004043 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511145004044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145004045 dimer interface [polypeptide binding]; other site 511145004046 conserved gate region; other site 511145004047 putative PBP binding loops; other site 511145004048 ABC-ATPase subunit interface; other site 511145004049 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511145004050 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 511145004051 putative NAD(P) binding site [chemical binding]; other site 511145004052 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 511145004053 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 511145004054 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 511145004055 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 511145004056 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 511145004057 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 511145004058 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 511145004059 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 511145004060 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 511145004061 beta-phosphoglucomutase; Region: bPGM; TIGR01990 511145004062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145004063 motif II; other site 511145004064 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 511145004065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511145004066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145004067 DNA binding site [nucleotide binding] 511145004068 domain linker motif; other site 511145004069 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 511145004070 putative dimerization interface [polypeptide binding]; other site 511145004071 putative ligand binding site [chemical binding]; other site 511145004072 Predicted ATPase [General function prediction only]; Region: COG3106 511145004073 hypothetical protein; Provisional; Region: PRK05415 511145004074 Predicted membrane protein [Function unknown]; Region: COG3768 511145004075 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 511145004076 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 511145004077 putative aromatic amino acid binding site; other site 511145004078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145004079 putative active site [active] 511145004080 heme pocket [chemical binding]; other site 511145004081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145004082 Walker A motif; other site 511145004083 ATP binding site [chemical binding]; other site 511145004084 Walker B motif; other site 511145004085 arginine finger; other site 511145004086 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 511145004087 dimer interface [polypeptide binding]; other site 511145004088 catalytic triad [active] 511145004089 peroxidatic and resolving cysteines [active] 511145004090 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 511145004091 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 511145004092 active site 511145004093 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 511145004094 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 511145004095 putative active site [active] 511145004096 Zn binding site [ion binding]; other site 511145004097 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 511145004098 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 511145004099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145004100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145004101 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 511145004102 putative effector binding pocket; other site 511145004103 putative dimerization interface [polypeptide binding]; other site 511145004104 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511145004105 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511145004106 peptide binding site [polypeptide binding]; other site 511145004107 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 511145004108 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511145004109 Transposase domain (DUF772); Region: DUF772; pfam05598 511145004110 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145004111 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145004112 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145004113 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 511145004114 universal stress protein UspE; Provisional; Region: PRK11175 511145004115 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511145004116 Ligand Binding Site [chemical binding]; other site 511145004117 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511145004118 Ligand Binding Site [chemical binding]; other site 511145004119 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 511145004120 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 511145004121 ligand binding site [chemical binding]; other site 511145004122 flexible hinge region; other site 511145004123 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 511145004124 putative switch regulator; other site 511145004125 non-specific DNA interactions [nucleotide binding]; other site 511145004126 DNA binding site [nucleotide binding] 511145004127 sequence specific DNA binding site [nucleotide binding]; other site 511145004128 putative cAMP binding site [chemical binding]; other site 511145004129 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 511145004130 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 511145004131 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 511145004132 DNA binding site [nucleotide binding] 511145004133 active site 511145004134 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 511145004135 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 511145004136 amidohydrolase; Region: amidohydrolases; TIGR01891 511145004137 putative metal binding site [ion binding]; other site 511145004138 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 511145004139 amidohydrolase; Region: amidohydrolases; TIGR01891 511145004140 putative metal binding site [ion binding]; other site 511145004141 dimer interface [polypeptide binding]; other site 511145004142 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 511145004143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145004144 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 511145004145 putative substrate binding pocket [chemical binding]; other site 511145004146 putative dimerization interface [polypeptide binding]; other site 511145004147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 511145004148 Smr domain; Region: Smr; pfam01713 511145004149 PAS domain S-box; Region: sensory_box; TIGR00229 511145004150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145004151 putative active site [active] 511145004152 heme pocket [chemical binding]; other site 511145004153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145004154 metal binding site [ion binding]; metal-binding site 511145004155 active site 511145004156 I-site; other site 511145004157 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 511145004158 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 511145004159 Cl binding site [ion binding]; other site 511145004160 oligomer interface [polypeptide binding]; other site 511145004161 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 511145004162 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511145004163 ATP binding site [chemical binding]; other site 511145004164 Mg++ binding site [ion binding]; other site 511145004165 motif III; other site 511145004166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145004167 nucleotide binding region [chemical binding]; other site 511145004168 ATP-binding site [chemical binding]; other site 511145004169 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 511145004170 putative RNA binding site [nucleotide binding]; other site 511145004171 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 511145004172 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 511145004173 Ligand Binding Site [chemical binding]; other site 511145004174 cryptic prophage Rac 511145004175 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 511145004176 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 511145004177 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 511145004178 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 511145004179 Int/Topo IB signature motif; other site 511145004180 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 511145004181 Protein of unknown function (DUF1187); Region: DUF1187; pfam06688 511145004182 restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710 511145004183 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 511145004184 exonuclease VIII; Reviewed; Region: PRK09709 511145004185 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 511145004186 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 511145004187 hypothetical protein; Reviewed; Region: PRK09790 511145004188 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 511145004189 Superinfection exclusion protein B; Region: SieB; pfam14163 511145004190 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 511145004191 UBA-like domain; Region: UBA_4; pfam14555 511145004192 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 511145004193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145004194 sequence-specific DNA binding site [nucleotide binding]; other site 511145004195 salt bridge; other site 511145004196 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 511145004197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 511145004198 primosomal protein DnaI; Provisional; Region: PRK02854 511145004199 putative replication protein; Provisional; Region: PRK12377 511145004200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145004201 Walker A motif; other site 511145004202 ATP binding site [chemical binding]; other site 511145004203 Walker B motif; other site 511145004204 arginine finger; other site 511145004205 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 511145004206 Cation transport protein; Region: TrkH; cl17365 511145004207 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 511145004208 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 511145004209 ParB-like nuclease domain; Region: ParBc; pfam02195 511145004210 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 511145004211 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 511145004212 Phage Tail Collar Domain; Region: Collar; pfam07484 511145004213 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 511145004214 multiple promoter invertase; Provisional; Region: mpi; PRK13413 511145004215 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511145004216 catalytic residues [active] 511145004217 catalytic nucleophile [active] 511145004218 Presynaptic Site I dimer interface [polypeptide binding]; other site 511145004219 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511145004220 Synaptic Flat tetramer interface [polypeptide binding]; other site 511145004221 Synaptic Site I dimer interface [polypeptide binding]; other site 511145004222 DNA binding site [nucleotide binding] 511145004223 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 511145004224 DNA-binding interface [nucleotide binding]; DNA binding site 511145004225 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511145004226 Ligand Binding Site [chemical binding]; other site 511145004227 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 511145004228 trimer interface [polypeptide binding]; other site 511145004229 eyelet of channel; other site 511145004230 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 511145004231 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511145004232 dimer interface [polypeptide binding]; other site 511145004233 PYR/PP interface [polypeptide binding]; other site 511145004234 TPP binding site [chemical binding]; other site 511145004235 substrate binding site [chemical binding]; other site 511145004236 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 511145004237 Domain of unknown function; Region: EKR; pfam10371 511145004238 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 511145004239 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 511145004240 TPP-binding site [chemical binding]; other site 511145004241 dimer interface [polypeptide binding]; other site 511145004242 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 511145004243 heat-inducible protein; Provisional; Region: PRK10449 511145004244 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 511145004245 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 511145004246 putative ligand binding site [chemical binding]; other site 511145004247 putative NAD binding site [chemical binding]; other site 511145004248 catalytic site [active] 511145004249 hypothetical protein; Provisional; Region: PRK10695 511145004250 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 511145004251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 511145004252 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 511145004253 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 511145004254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145004255 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 511145004256 NAD(P) binding site [chemical binding]; other site 511145004257 catalytic residues [active] 511145004258 tyramine oxidase; Provisional; Region: tynA; PRK14696 511145004259 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511145004260 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 511145004261 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 511145004262 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 511145004263 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 511145004264 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 511145004265 substrate binding site [chemical binding]; other site 511145004266 dimer interface [polypeptide binding]; other site 511145004267 NADP binding site [chemical binding]; other site 511145004268 catalytic residues [active] 511145004269 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 511145004270 substrate binding site [chemical binding]; other site 511145004271 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 511145004272 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 511145004273 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 511145004274 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 511145004275 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 511145004276 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 511145004277 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 511145004278 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 511145004279 FAD binding pocket [chemical binding]; other site 511145004280 FAD binding motif [chemical binding]; other site 511145004281 phosphate binding motif [ion binding]; other site 511145004282 beta-alpha-beta structure motif; other site 511145004283 NAD(p) ribose binding residues [chemical binding]; other site 511145004284 NAD binding pocket [chemical binding]; other site 511145004285 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 511145004286 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511145004287 catalytic loop [active] 511145004288 iron binding site [ion binding]; other site 511145004289 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 511145004290 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511145004291 substrate binding site [chemical binding]; other site 511145004292 oxyanion hole (OAH) forming residues; other site 511145004293 trimer interface [polypeptide binding]; other site 511145004294 enoyl-CoA hydratase; Provisional; Region: PRK08140 511145004295 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511145004296 substrate binding site [chemical binding]; other site 511145004297 oxyanion hole (OAH) forming residues; other site 511145004298 trimer interface [polypeptide binding]; other site 511145004299 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 511145004300 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 511145004301 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511145004302 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511145004303 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 511145004304 CoenzymeA binding site [chemical binding]; other site 511145004305 subunit interaction site [polypeptide binding]; other site 511145004306 PHB binding site; other site 511145004307 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 511145004308 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 511145004309 dimer interface [polypeptide binding]; other site 511145004310 active site 511145004311 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 511145004312 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 511145004313 active site 511145004314 AMP binding site [chemical binding]; other site 511145004315 homodimer interface [polypeptide binding]; other site 511145004316 acyl-activating enzyme (AAE) consensus motif; other site 511145004317 CoA binding site [chemical binding]; other site 511145004318 PaaX-like protein; Region: PaaX; pfam07848 511145004319 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 511145004320 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 511145004321 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 511145004322 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 511145004323 putative trimer interface [polypeptide binding]; other site 511145004324 putative metal binding site [ion binding]; other site 511145004325 IS2 transposase TnpB; Reviewed; Region: PRK09409 511145004326 HTH-like domain; Region: HTH_21; pfam13276 511145004327 Integrase core domain; Region: rve; pfam00665 511145004328 Integrase core domain; Region: rve_3; pfam13683 511145004329 IS2 repressor TnpA; Reviewed; Region: PRK09413 511145004330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145004331 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511145004332 Helix-turn-helix domain; Region: HTH_38; pfam13936 511145004333 Homeodomain-like domain; Region: HTH_32; pfam13565 511145004334 Integrase core domain; Region: rve; pfam00665 511145004335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511145004336 active site 511145004337 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 511145004338 catalytic tetrad [active] 511145004339 Protein of unknown function (DUF342); Region: DUF342; cl19219 511145004340 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 511145004341 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 511145004342 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 511145004343 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 511145004344 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 511145004345 Putative methyltransferase; Region: Methyltransf_20; pfam12147 511145004346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145004347 S-adenosylmethionine binding site [chemical binding]; other site 511145004348 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 511145004349 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 511145004350 active site 511145004351 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cd00127 511145004352 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 511145004353 active site 511145004354 catalytic residues [active] 511145004355 azoreductase; Reviewed; Region: PRK00170 511145004356 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 511145004357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145004358 ATP binding site [chemical binding]; other site 511145004359 putative Mg++ binding site [ion binding]; other site 511145004360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145004361 nucleotide binding region [chemical binding]; other site 511145004362 ATP-binding site [chemical binding]; other site 511145004363 Helicase associated domain (HA2); Region: HA2; pfam04408 511145004364 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 511145004365 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 511145004366 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 511145004367 putative active site [active] 511145004368 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 511145004369 NAD binding site [chemical binding]; other site 511145004370 catalytic residues [active] 511145004371 substrate binding site [chemical binding]; other site 511145004372 cytochrome b561; Provisional; Region: PRK11513 511145004373 hypothetical protein; Provisional; Region: PRK10040 511145004374 small toxic polypeptide; Provisional; Region: PRK09738 511145004375 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 511145004376 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 511145004377 dimer interface [polypeptide binding]; other site 511145004378 ligand binding site [chemical binding]; other site 511145004379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145004380 dimerization interface [polypeptide binding]; other site 511145004381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 511145004382 dimer interface [polypeptide binding]; other site 511145004383 putative CheW interface [polypeptide binding]; other site 511145004384 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 511145004385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145004386 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145004387 dimerization interface [polypeptide binding]; other site 511145004388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 511145004389 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 511145004390 hypothetical protein; Provisional; Region: PRK11415 511145004391 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511145004392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145004393 Coenzyme A binding pocket [chemical binding]; other site 511145004394 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 511145004395 putative trimer interface [polypeptide binding]; other site 511145004396 putative CoA binding site [chemical binding]; other site 511145004397 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 511145004398 putative trimer interface [polypeptide binding]; other site 511145004399 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 511145004400 putative CoA binding site [chemical binding]; other site 511145004401 putative trimer interface [polypeptide binding]; other site 511145004402 putative CoA binding site [chemical binding]; other site 511145004403 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 511145004404 gating phenylalanine in ion channel; other site 511145004405 tellurite resistance protein TehB; Provisional; Region: PRK11207 511145004406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145004407 S-adenosylmethionine binding site [chemical binding]; other site 511145004408 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 511145004409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 511145004410 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 511145004411 Probable transposase; Region: OrfB_IS605; pfam01385 511145004412 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 511145004413 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 511145004414 benzoate transporter; Region: benE; TIGR00843 511145004415 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511145004416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145004417 non-specific DNA binding site [nucleotide binding]; other site 511145004418 salt bridge; other site 511145004419 sequence-specific DNA binding site [nucleotide binding]; other site 511145004420 Cupin domain; Region: Cupin_2; pfam07883 511145004421 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 511145004422 Collagenase; Region: DUF3656; pfam12392 511145004423 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 511145004424 YcfA-like protein; Region: YcfA; pfam07927 511145004425 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 511145004426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145004427 sequence-specific DNA binding site [nucleotide binding]; other site 511145004428 salt bridge; other site 511145004429 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 511145004430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145004431 DNA-binding site [nucleotide binding]; DNA binding site 511145004432 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145004433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145004434 homodimer interface [polypeptide binding]; other site 511145004435 catalytic residue [active] 511145004436 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 511145004437 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511145004438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145004439 Walker A/P-loop; other site 511145004440 ATP binding site [chemical binding]; other site 511145004441 Q-loop/lid; other site 511145004442 ABC transporter signature motif; other site 511145004443 Walker B; other site 511145004444 D-loop; other site 511145004445 H-loop/switch region; other site 511145004446 TOBE domain; Region: TOBE_2; pfam08402 511145004447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145004448 dimer interface [polypeptide binding]; other site 511145004449 conserved gate region; other site 511145004450 putative PBP binding loops; other site 511145004451 ABC-ATPase subunit interface; other site 511145004452 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 511145004453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145004454 dimer interface [polypeptide binding]; other site 511145004455 conserved gate region; other site 511145004456 putative PBP binding loops; other site 511145004457 ABC-ATPase subunit interface; other site 511145004458 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 511145004459 tetrameric interface [polypeptide binding]; other site 511145004460 NAD binding site [chemical binding]; other site 511145004461 catalytic residues [active] 511145004462 substrate binding site [chemical binding]; other site 511145004463 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 511145004464 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 511145004465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 511145004466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 511145004467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145004468 Coenzyme A binding pocket [chemical binding]; other site 511145004469 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 511145004470 Prostaglandin dehydrogenases; Region: PGDH; cd05288 511145004471 NAD(P) binding site [chemical binding]; other site 511145004472 substrate binding site [chemical binding]; other site 511145004473 dimer interface [polypeptide binding]; other site 511145004474 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 511145004475 DNA-binding site [nucleotide binding]; DNA binding site 511145004476 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 511145004477 FCD domain; Region: FCD; pfam07729 511145004478 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 511145004479 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 511145004480 N-terminal plug; other site 511145004481 ligand-binding site [chemical binding]; other site 511145004482 Uncharacterized conserved protein [Function unknown]; Region: COG3391 511145004483 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 511145004484 L-asparagine permease; Provisional; Region: PRK15049 511145004485 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145004486 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 511145004487 C-terminal domain interface [polypeptide binding]; other site 511145004488 GSH binding site (G-site) [chemical binding]; other site 511145004489 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 511145004490 dimer interface [polypeptide binding]; other site 511145004491 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 511145004492 N-terminal domain interface [polypeptide binding]; other site 511145004493 dimer interface [polypeptide binding]; other site 511145004494 substrate binding pocket (H-site) [chemical binding]; other site 511145004495 Transposase [DNA replication, recombination, and repair]; Region: COG5433 511145004496 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511145004497 Transposase [DNA replication, recombination, and repair]; Region: COG5433 511145004498 Transposase [DNA replication, recombination, and repair]; Region: COG5433 511145004499 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 511145004500 active site 1 [active] 511145004501 dimer interface [polypeptide binding]; other site 511145004502 hexamer interface [polypeptide binding]; other site 511145004503 active site 2 [active] 511145004504 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 511145004505 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 511145004506 hypothetical protein; Provisional; Region: PRK10281 511145004507 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 511145004508 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 511145004509 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 511145004510 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 511145004511 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145004512 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 511145004513 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 511145004514 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 511145004515 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 511145004516 [4Fe-4S] binding site [ion binding]; other site 511145004517 molybdopterin cofactor binding site [chemical binding]; other site 511145004518 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 511145004519 molybdopterin cofactor binding site; other site 511145004520 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 511145004521 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 511145004522 aromatic amino acid exporter; Provisional; Region: PRK11689 511145004523 EamA-like transporter family; Region: EamA; pfam00892 511145004524 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 511145004525 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 511145004526 [4Fe-4S] binding site [ion binding]; other site 511145004527 molybdopterin cofactor binding site; other site 511145004528 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 511145004529 molybdopterin cofactor binding site; other site 511145004530 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 511145004531 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145004532 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 511145004533 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 511145004534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145004535 non-specific DNA binding site [nucleotide binding]; other site 511145004536 salt bridge; other site 511145004537 sequence-specific DNA binding site [nucleotide binding]; other site 511145004538 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 511145004539 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 511145004540 NAD binding site [chemical binding]; other site 511145004541 substrate binding site [chemical binding]; other site 511145004542 catalytic Zn binding site [ion binding]; other site 511145004543 tetramer interface [polypeptide binding]; other site 511145004544 structural Zn binding site [ion binding]; other site 511145004545 malate dehydrogenase; Provisional; Region: PRK13529 511145004546 Malic enzyme, N-terminal domain; Region: malic; pfam00390 511145004547 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 511145004548 NAD(P) binding site [chemical binding]; other site 511145004549 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 511145004550 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 511145004551 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 511145004552 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 511145004553 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145004554 Walker A/P-loop; other site 511145004555 ATP binding site [chemical binding]; other site 511145004556 Q-loop/lid; other site 511145004557 ABC transporter signature motif; other site 511145004558 Walker B; other site 511145004559 D-loop; other site 511145004560 H-loop/switch region; other site 511145004561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 511145004562 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 511145004563 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145004564 Walker A/P-loop; other site 511145004565 ATP binding site [chemical binding]; other site 511145004566 Q-loop/lid; other site 511145004567 ABC transporter signature motif; other site 511145004568 Walker B; other site 511145004569 D-loop; other site 511145004570 H-loop/switch region; other site 511145004571 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 511145004572 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 511145004573 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 511145004574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145004575 dimer interface [polypeptide binding]; other site 511145004576 conserved gate region; other site 511145004577 putative PBP binding loops; other site 511145004578 ABC-ATPase subunit interface; other site 511145004579 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511145004580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145004581 dimer interface [polypeptide binding]; other site 511145004582 conserved gate region; other site 511145004583 putative PBP binding loops; other site 511145004584 ABC-ATPase subunit interface; other site 511145004585 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 511145004586 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 511145004587 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 511145004588 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 511145004589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145004590 putative active site [active] 511145004591 heme pocket [chemical binding]; other site 511145004592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145004593 putative active site [active] 511145004594 heme pocket [chemical binding]; other site 511145004595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145004596 metal binding site [ion binding]; metal-binding site 511145004597 active site 511145004598 I-site; other site 511145004599 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145004600 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 511145004601 heme-binding site [chemical binding]; other site 511145004602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145004603 metal binding site [ion binding]; metal-binding site 511145004604 active site 511145004605 I-site; other site 511145004606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 511145004607 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 511145004608 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 511145004609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145004610 catalytic residue [active] 511145004611 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511145004612 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 511145004613 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511145004614 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511145004615 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511145004616 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 511145004617 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 511145004618 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 511145004619 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 511145004620 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 511145004621 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 511145004622 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145004623 FeS/SAM binding site; other site 511145004624 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 511145004625 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 511145004626 Sulfatase; Region: Sulfatase; pfam00884 511145004627 transcriptional regulator YdeO; Provisional; Region: PRK09940 511145004628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145004629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145004630 putative oxidoreductase; Provisional; Region: PRK09939 511145004631 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 511145004632 putative molybdopterin cofactor binding site [chemical binding]; other site 511145004633 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 511145004634 putative molybdopterin cofactor binding site; other site 511145004635 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 511145004636 mannosyl binding site [chemical binding]; other site 511145004637 Fimbrial protein; Region: Fimbrial; pfam00419 511145004638 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 511145004639 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 511145004640 Dif; site of action for XerCD chromosome resolvase; required for proper segregation of circular daughter chromosomes; Dif; recA-independent recombination site in terminus 511145004641 HipA N-terminal domain; Region: couple_hipA; TIGR03071 511145004642 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 511145004643 HipA-like N-terminal domain; Region: HipA_N; pfam07805 511145004644 HipA-like C-terminal domain; Region: HipA_C; pfam07804 511145004645 beta subunit of N-acylethanolamine-hydrolyzing acid amidase; Region: NAAA-beta; pfam15508 511145004646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511145004647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145004648 non-specific DNA binding site [nucleotide binding]; other site 511145004649 salt bridge; other site 511145004650 sequence-specific DNA binding site [nucleotide binding]; other site 511145004651 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 511145004652 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 511145004653 putative N- and C-terminal domain interface [polypeptide binding]; other site 511145004654 putative active site [active] 511145004655 putative MgATP binding site [chemical binding]; other site 511145004656 catalytic site [active] 511145004657 metal binding site [ion binding]; metal-binding site 511145004658 putative carbohydrate binding site [chemical binding]; other site 511145004659 transcriptional regulator LsrR; Provisional; Region: PRK15418 511145004660 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 511145004661 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 511145004662 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 511145004663 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511145004664 Walker A/P-loop; other site 511145004665 ATP binding site [chemical binding]; other site 511145004666 Q-loop/lid; other site 511145004667 ABC transporter signature motif; other site 511145004668 Walker B; other site 511145004669 D-loop; other site 511145004670 H-loop/switch region; other site 511145004671 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511145004672 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145004673 TM-ABC transporter signature motif; other site 511145004674 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145004675 TM-ABC transporter signature motif; other site 511145004676 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 511145004677 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 511145004678 ligand binding site [chemical binding]; other site 511145004679 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 511145004680 putative active site; other site 511145004681 catalytic residue [active] 511145004682 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 511145004683 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 511145004684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145004685 S-adenosylmethionine binding site [chemical binding]; other site 511145004686 Predicted membrane protein [Function unknown]; Region: COG3781 511145004687 altronate oxidoreductase; Provisional; Region: PRK03643 511145004688 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 511145004689 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 511145004690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145004691 metal binding site [ion binding]; metal-binding site 511145004692 active site 511145004693 I-site; other site 511145004694 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 511145004695 glutaminase; Provisional; Region: PRK00971 511145004696 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 511145004697 NAD(P) binding site [chemical binding]; other site 511145004698 catalytic residues [active] 511145004699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145004700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145004701 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 511145004702 putative dimerization interface [polypeptide binding]; other site 511145004703 putative arabinose transporter; Provisional; Region: PRK03545 511145004704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145004705 putative substrate translocation pore; other site 511145004706 inner membrane protein; Provisional; Region: PRK10995 511145004707 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 511145004708 Transcriptional regulators [Transcription]; Region: MarR; COG1846 511145004709 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 511145004710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145004711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145004712 MarB protein; Region: MarB; pfam13999 511145004713 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 511145004714 EamA-like transporter family; Region: EamA; pfam00892 511145004715 EamA-like transporter family; Region: EamA; pfam00892 511145004716 putative transporter; Provisional; Region: PRK10054 511145004717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145004718 putative substrate translocation pore; other site 511145004719 diguanylate cyclase; Provisional; Region: PRK09894 511145004720 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 511145004721 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145004722 metal binding site [ion binding]; metal-binding site 511145004723 active site 511145004724 I-site; other site 511145004725 hypothetical protein; Provisional; Region: PRK10053 511145004726 hypothetical protein; Validated; Region: PRK03657 511145004727 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 511145004728 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 511145004729 active site 511145004730 Zn binding site [ion binding]; other site 511145004731 malonic semialdehyde reductase; Provisional; Region: PRK10538 511145004732 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 511145004733 putative NAD(P) binding site [chemical binding]; other site 511145004734 homodimer interface [polypeptide binding]; other site 511145004735 homotetramer interface [polypeptide binding]; other site 511145004736 active site 511145004737 Transcriptional regulators [Transcription]; Region: GntR; COG1802 511145004738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145004739 DNA-binding site [nucleotide binding]; DNA binding site 511145004740 FCD domain; Region: FCD; pfam07729 511145004741 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 511145004742 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 511145004743 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 511145004744 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 511145004745 cryptic prophage Qin/Kim 511145004746 multiple promoter invertase; Provisional; Region: mpi; PRK13413 511145004747 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511145004748 catalytic residues [active] 511145004749 catalytic nucleophile [active] 511145004750 Presynaptic Site I dimer interface [polypeptide binding]; other site 511145004751 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511145004752 Synaptic Flat tetramer interface [polypeptide binding]; other site 511145004753 Synaptic Site I dimer interface [polypeptide binding]; other site 511145004754 DNA binding site [nucleotide binding] 511145004755 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 511145004756 DNA-binding interface [nucleotide binding]; DNA binding site 511145004757 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 511145004758 Phage Tail Collar Domain; Region: Collar; pfam07484 511145004759 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 511145004760 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 511145004761 GnsA/GnsB family; Region: GnsAB; pfam08178 511145004762 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511145004763 DNA-binding site [nucleotide binding]; DNA binding site 511145004764 RNA-binding motif; other site 511145004765 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 511145004766 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 511145004767 catalytic residues [active] 511145004768 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 511145004769 Lysis protein S; Region: Lysis_S; pfam04971 511145004770 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511145004771 DNA-binding site [nucleotide binding]; DNA binding site 511145004772 RNA-binding motif; other site 511145004773 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511145004774 DNA-binding site [nucleotide binding]; DNA binding site 511145004775 RNA-binding motif; other site 511145004776 Antitermination protein; Region: Antiterm; pfam03589 511145004777 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 511145004778 Antitermination protein; Region: Antiterm; pfam03589 511145004779 Protein of unknown function (DUF968); Region: DUF968; pfam06147 511145004780 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 511145004781 active site 511145004782 Hok/gef family; Region: HOK_GEF; pfam01848 511145004783 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 511145004784 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 511145004785 FlxA-like protein; Region: FlxA; pfam14282 511145004786 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 511145004787 transcriptional repressor DicA; Reviewed; Region: PRK09706 511145004788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145004789 non-specific DNA binding site [nucleotide binding]; other site 511145004790 salt bridge; other site 511145004791 sequence-specific DNA binding site [nucleotide binding]; other site 511145004792 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 511145004793 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 511145004794 DicB protein; Region: DicB; pfam05358 511145004795 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 511145004796 putative oxidoreductase; Provisional; Region: PRK10083 511145004797 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 511145004798 putative NAD(P) binding site [chemical binding]; other site 511145004799 catalytic Zn binding site [ion binding]; other site 511145004800 structural Zn binding site [ion binding]; other site 511145004801 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 511145004802 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 511145004803 putative active site pocket [active] 511145004804 putative metal binding site [ion binding]; other site 511145004805 hypothetical protein; Provisional; Region: PRK02237 511145004806 hypothetical protein; Provisional; Region: PRK13659 511145004807 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511145004808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145004809 Coenzyme A binding pocket [chemical binding]; other site 511145004810 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 511145004811 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 511145004812 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 511145004813 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 511145004814 putative [Fe4-S4] binding site [ion binding]; other site 511145004815 putative molybdopterin cofactor binding site [chemical binding]; other site 511145004816 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 511145004817 putative molybdopterin cofactor binding site; other site 511145004818 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 511145004819 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 511145004820 putative [Fe4-S4] binding site [ion binding]; other site 511145004821 putative molybdopterin cofactor binding site [chemical binding]; other site 511145004822 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 511145004823 putative molybdopterin cofactor binding site; other site 511145004824 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 511145004825 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145004826 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 511145004827 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 511145004828 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 511145004829 Cl- selectivity filter; other site 511145004830 Cl- binding residues [ion binding]; other site 511145004831 pore gating glutamate residue; other site 511145004832 dimer interface [polypeptide binding]; other site 511145004833 putative dithiobiotin synthetase; Provisional; Region: PRK12374 511145004834 AAA domain; Region: AAA_26; pfam13500 511145004835 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 511145004836 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511145004837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145004838 nucleotide binding site [chemical binding]; other site 511145004839 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 511145004840 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 511145004841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145004842 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 511145004843 dimerization interface [polypeptide binding]; other site 511145004844 substrate binding pocket [chemical binding]; other site 511145004845 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 511145004846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145004847 putative substrate translocation pore; other site 511145004848 hypothetical protein; Provisional; Region: PRK14758 511145004849 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 511145004850 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 511145004851 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 511145004852 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 511145004853 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 511145004854 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 511145004855 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 511145004856 ligand binding site [chemical binding]; other site 511145004857 homodimer interface [polypeptide binding]; other site 511145004858 NAD(P) binding site [chemical binding]; other site 511145004859 trimer interface B [polypeptide binding]; other site 511145004860 trimer interface A [polypeptide binding]; other site 511145004861 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 511145004862 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 511145004863 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 511145004864 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 511145004865 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 511145004866 Spore germination protein; Region: Spore_permease; cl17796 511145004867 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 511145004868 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 511145004869 NADP binding site [chemical binding]; other site 511145004870 substrate binding pocket [chemical binding]; other site 511145004871 active site 511145004872 GlpM protein; Region: GlpM; pfam06942 511145004873 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 511145004874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145004875 active site 511145004876 phosphorylation site [posttranslational modification] 511145004877 intermolecular recognition site; other site 511145004878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145004879 DNA binding site [nucleotide binding] 511145004880 sensor protein RstB; Provisional; Region: PRK10604 511145004881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145004882 dimerization interface [polypeptide binding]; other site 511145004883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145004884 dimer interface [polypeptide binding]; other site 511145004885 phosphorylation site [posttranslational modification] 511145004886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145004887 ATP binding site [chemical binding]; other site 511145004888 Mg2+ binding site [ion binding]; other site 511145004889 G-X-G motif; other site 511145004890 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 511145004891 fumarate hydratase; Reviewed; Region: fumC; PRK00485 511145004892 Class II fumarases; Region: Fumarase_classII; cd01362 511145004893 active site 511145004894 tetramer interface [polypeptide binding]; other site 511145004895 fumarate hydratase; Provisional; Region: PRK15389 511145004896 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 511145004897 Fumarase C-terminus; Region: Fumerase_C; pfam05683 511145004898 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 511145004899 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 511145004900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 511145004901 putative outer membrane porin protein; Provisional; Region: PRK11379 511145004902 glucuronide transporter; Provisional; Region: PRK09848 511145004903 putative symporter YagG; Provisional; Region: PRK09669; cl15392 511145004904 beta-D-glucuronidase; Provisional; Region: PRK10150 511145004905 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 511145004906 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 511145004907 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 511145004908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511145004909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145004910 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 511145004911 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 511145004912 NAD binding site [chemical binding]; other site 511145004913 substrate binding site [chemical binding]; other site 511145004914 homotetramer interface [polypeptide binding]; other site 511145004915 homodimer interface [polypeptide binding]; other site 511145004916 active site 511145004917 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 511145004918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145004919 DNA binding site [nucleotide binding] 511145004920 domain linker motif; other site 511145004921 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 511145004922 putative dimerization interface [polypeptide binding]; other site 511145004923 putative ligand binding site [chemical binding]; other site 511145004924 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 511145004925 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 511145004926 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511145004927 active site turn [active] 511145004928 phosphorylation site [posttranslational modification] 511145004929 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 511145004930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145004931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145004932 homodimer interface [polypeptide binding]; other site 511145004933 catalytic residue [active] 511145004934 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 511145004935 active site 511145004936 purine riboside binding site [chemical binding]; other site 511145004937 putative oxidoreductase; Provisional; Region: PRK11579 511145004938 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 511145004939 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 511145004940 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 511145004941 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 511145004942 electron transport complex protein RsxA; Provisional; Region: PRK05151 511145004943 electron transport complex protein RnfB; Provisional; Region: PRK05113 511145004944 Putative Fe-S cluster; Region: FeS; pfam04060 511145004945 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145004946 electron transport complex protein RnfC; Provisional; Region: PRK05035 511145004947 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 511145004948 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 511145004949 SLBB domain; Region: SLBB; pfam10531 511145004950 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 511145004951 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 511145004952 electron transport complex protein RnfG; Validated; Region: PRK01908 511145004953 electron transport complex RsxE subunit; Provisional; Region: PRK12405 511145004954 endonuclease III; Provisional; Region: PRK10702 511145004955 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511145004956 minor groove reading motif; other site 511145004957 helix-hairpin-helix signature motif; other site 511145004958 substrate binding pocket [chemical binding]; other site 511145004959 active site 511145004960 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 511145004961 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 511145004962 putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584 511145004963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145004964 putative substrate translocation pore; other site 511145004965 glutathionine S-transferase; Provisional; Region: PRK10542 511145004966 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 511145004967 C-terminal domain interface [polypeptide binding]; other site 511145004968 GSH binding site (G-site) [chemical binding]; other site 511145004969 dimer interface [polypeptide binding]; other site 511145004970 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 511145004971 N-terminal domain interface [polypeptide binding]; other site 511145004972 dimer interface [polypeptide binding]; other site 511145004973 substrate binding pocket (H-site) [chemical binding]; other site 511145004974 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 511145004975 dimer interface [polypeptide binding]; other site 511145004976 pyridoxal binding site [chemical binding]; other site 511145004977 ATP binding site [chemical binding]; other site 511145004978 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 511145004979 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 511145004980 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 511145004981 active site 511145004982 HIGH motif; other site 511145004983 dimer interface [polypeptide binding]; other site 511145004984 KMSKS motif; other site 511145004985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511145004986 RNA binding surface [nucleotide binding]; other site 511145004987 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 511145004988 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 511145004989 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 511145004990 lysozyme inhibitor; Provisional; Region: PRK11372 511145004991 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 511145004992 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 511145004993 transcriptional regulator SlyA; Provisional; Region: PRK03573 511145004994 Transcriptional regulators [Transcription]; Region: MarR; COG1846 511145004995 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 511145004996 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 511145004997 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145004998 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145004999 Fusaric acid resistance protein family; Region: FUSC; pfam04632 511145005000 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 511145005001 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 511145005002 E-class dimer interface [polypeptide binding]; other site 511145005003 P-class dimer interface [polypeptide binding]; other site 511145005004 active site 511145005005 Cu2+ binding site [ion binding]; other site 511145005006 Zn2+ binding site [ion binding]; other site 511145005007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511145005008 active site 511145005009 catalytic tetrad [active] 511145005010 Predicted Fe-S protein [General function prediction only]; Region: COG3313 511145005011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511145005012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145005013 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 511145005014 FMN binding site [chemical binding]; other site 511145005015 active site 511145005016 substrate binding site [chemical binding]; other site 511145005017 catalytic residue [active] 511145005018 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 511145005019 dimer interface [polypeptide binding]; other site 511145005020 active site 511145005021 metal binding site [ion binding]; metal-binding site 511145005022 glutathione binding site [chemical binding]; other site 511145005023 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 511145005024 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 511145005025 dimer interface [polypeptide binding]; other site 511145005026 catalytic site [active] 511145005027 putative active site [active] 511145005028 putative substrate binding site [chemical binding]; other site 511145005029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145005030 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 511145005031 ATP binding site [chemical binding]; other site 511145005032 putative Mg++ binding site [ion binding]; other site 511145005033 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145005034 nucleotide binding region [chemical binding]; other site 511145005035 ATP-binding site [chemical binding]; other site 511145005036 DEAD/H associated; Region: DEAD_assoc; pfam08494 511145005037 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 511145005038 putative GSH binding site [chemical binding]; other site 511145005039 catalytic residues [active] 511145005040 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511145005041 NlpC/P60 family; Region: NLPC_P60; pfam00877 511145005042 superoxide dismutase; Provisional; Region: PRK10543 511145005043 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 511145005044 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 511145005045 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 511145005046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145005047 putative substrate translocation pore; other site 511145005048 hypothetical protein; Provisional; Region: PRK14756 511145005049 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 511145005050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145005051 DNA binding site [nucleotide binding] 511145005052 domain linker motif; other site 511145005053 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 511145005054 dimerization interface [polypeptide binding]; other site 511145005055 ligand binding site [chemical binding]; other site 511145005056 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 511145005057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145005058 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145005059 dimerization interface [polypeptide binding]; other site 511145005060 putative transporter; Provisional; Region: PRK11043 511145005061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145005062 putative substrate translocation pore; other site 511145005063 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 511145005064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 511145005065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145005066 S-adenosylmethionine binding site [chemical binding]; other site 511145005067 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 511145005068 Lumazine binding domain; Region: Lum_binding; pfam00677 511145005069 Lumazine binding domain; Region: Lum_binding; pfam00677 511145005070 multidrug efflux protein; Reviewed; Region: PRK01766 511145005071 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 511145005072 cation binding site [ion binding]; other site 511145005073 hypothetical protein; Provisional; Region: PRK09945 511145005074 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 511145005075 putative monooxygenase; Provisional; Region: PRK11118 511145005076 hypothetical protein; Provisional; Region: PRK09897 511145005077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 511145005078 hypothetical protein; Provisional; Region: PRK09946 511145005079 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 511145005080 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 511145005081 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 511145005082 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145005083 hypothetical protein; Provisional; Region: PRK09947 511145005084 putative oxidoreductase; Provisional; Region: PRK09849 511145005085 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 511145005086 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 511145005087 hypothetical protein; Provisional; Region: PRK09898 511145005088 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145005089 hypothetical protein; Provisional; Region: PRK10292 511145005090 pyruvate kinase; Provisional; Region: PRK09206 511145005091 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 511145005092 domain interfaces; other site 511145005093 active site 511145005094 murein lipoprotein; Provisional; Region: PRK15396 511145005095 L,D-transpeptidase; Provisional; Region: PRK10260 511145005096 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511145005097 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 511145005098 cysteine desufuration protein SufE; Provisional; Region: PRK09296 511145005099 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 511145005100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511145005101 catalytic residue [active] 511145005102 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 511145005103 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 511145005104 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 511145005105 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 511145005106 Walker A/P-loop; other site 511145005107 ATP binding site [chemical binding]; other site 511145005108 Q-loop/lid; other site 511145005109 ABC transporter signature motif; other site 511145005110 Walker B; other site 511145005111 D-loop; other site 511145005112 H-loop/switch region; other site 511145005113 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 511145005114 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 511145005115 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 511145005116 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 511145005117 CoenzymeA binding site [chemical binding]; other site 511145005118 subunit interaction site [polypeptide binding]; other site 511145005119 PHB binding site; other site 511145005120 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 511145005121 FAD binding domain; Region: FAD_binding_4; pfam01565 511145005122 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 511145005123 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 511145005124 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 511145005125 putative inner membrane protein; Provisional; Region: PRK10983 511145005126 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 511145005127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145005128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511145005129 putative substrate translocation pore; other site 511145005130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145005131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511145005132 putative substrate translocation pore; other site 511145005133 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 511145005134 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 511145005135 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 511145005136 shikimate binding site; other site 511145005137 NAD(P) binding site [chemical binding]; other site 511145005138 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 511145005139 active site 511145005140 catalytic residue [active] 511145005141 dimer interface [polypeptide binding]; other site 511145005142 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 511145005143 Coenzyme A transferase; Region: CoA_trans; smart00882 511145005144 Coenzyme A transferase; Region: CoA_trans; cl17247 511145005145 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 511145005146 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 511145005147 active site 511145005148 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511145005149 Cupin domain; Region: Cupin_2; pfam07883 511145005150 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 511145005151 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511145005152 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 511145005153 Ligand binding site [chemical binding]; other site 511145005154 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 511145005155 Electron transfer flavoprotein domain; Region: ETF; pfam01012 511145005156 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 511145005157 oxidoreductase; Provisional; Region: PRK10015 511145005158 putative oxidoreductase FixC; Provisional; Region: PRK10157 511145005159 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 511145005160 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 511145005161 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 511145005162 acyl-activating enzyme (AAE) consensus motif; other site 511145005163 putative AMP binding site [chemical binding]; other site 511145005164 putative active site [active] 511145005165 putative CoA binding site [chemical binding]; other site 511145005166 phosphoenolpyruvate synthase; Validated; Region: PRK06464 511145005167 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 511145005168 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511145005169 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511145005170 PEP synthetase regulatory protein; Provisional; Region: PRK05339 511145005171 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 511145005172 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 511145005173 hypothetical protein; Validated; Region: PRK00029 511145005174 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 511145005175 NlpC/P60 family; Region: NLPC_P60; pfam00877 511145005176 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 511145005177 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511145005178 Walker A/P-loop; other site 511145005179 ATP binding site [chemical binding]; other site 511145005180 Q-loop/lid; other site 511145005181 ABC transporter signature motif; other site 511145005182 Walker B; other site 511145005183 D-loop; other site 511145005184 H-loop/switch region; other site 511145005185 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 511145005186 catalytic residues [active] 511145005187 dimer interface [polypeptide binding]; other site 511145005188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511145005189 ABC-ATPase subunit interface; other site 511145005190 dimer interface [polypeptide binding]; other site 511145005191 putative PBP binding regions; other site 511145005192 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 511145005193 DNA binding site [nucleotide binding] 511145005194 dimer interface [polypeptide binding]; other site 511145005195 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 511145005196 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511145005197 putative tRNA-binding site [nucleotide binding]; other site 511145005198 B3/4 domain; Region: B3_4; pfam03483 511145005199 tRNA synthetase B5 domain; Region: B5; smart00874 511145005200 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 511145005201 dimer interface [polypeptide binding]; other site 511145005202 motif 1; other site 511145005203 motif 3; other site 511145005204 motif 2; other site 511145005205 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 511145005206 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 511145005207 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 511145005208 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 511145005209 dimer interface [polypeptide binding]; other site 511145005210 motif 1; other site 511145005211 active site 511145005212 motif 2; other site 511145005213 motif 3; other site 511145005214 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 511145005215 23S rRNA binding site [nucleotide binding]; other site 511145005216 L21 binding site [polypeptide binding]; other site 511145005217 L13 binding site [polypeptide binding]; other site 511145005218 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 511145005219 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 511145005220 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 511145005221 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 511145005222 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 511145005223 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 511145005224 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 511145005225 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 511145005226 active site 511145005227 dimer interface [polypeptide binding]; other site 511145005228 motif 1; other site 511145005229 motif 2; other site 511145005230 motif 3; other site 511145005231 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 511145005232 anticodon binding site; other site 511145005233 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 511145005234 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 511145005235 putative substrate binding site [chemical binding]; other site 511145005236 putative ATP binding site [chemical binding]; other site 511145005237 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 511145005238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 511145005239 Phosphotransferase enzyme family; Region: APH; pfam01636 511145005240 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 511145005241 active site 511145005242 substrate binding site [chemical binding]; other site 511145005243 ATP binding site [chemical binding]; other site 511145005244 YniB-like protein; Region: YniB; pfam14002 511145005245 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 511145005246 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 511145005247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145005248 motif II; other site 511145005249 inner membrane protein; Provisional; Region: PRK11648 511145005250 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 511145005251 Cell division activator CedA; Region: CedA; pfam10729 511145005252 hydroperoxidase II; Provisional; Region: katE; PRK11249 511145005253 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 511145005254 tetramer interface [polypeptide binding]; other site 511145005255 heme binding pocket [chemical binding]; other site 511145005256 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 511145005257 domain interactions; other site 511145005258 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 511145005259 putative active site [active] 511145005260 YdjC motif; other site 511145005261 Mg binding site [ion binding]; other site 511145005262 putative homodimer interface [polypeptide binding]; other site 511145005263 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 511145005264 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 511145005265 NAD binding site [chemical binding]; other site 511145005266 sugar binding site [chemical binding]; other site 511145005267 divalent metal binding site [ion binding]; other site 511145005268 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511145005269 dimer interface [polypeptide binding]; other site 511145005270 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 511145005271 Cupin domain; Region: Cupin_2; cl17218 511145005272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145005273 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 511145005274 methionine cluster; other site 511145005275 active site 511145005276 phosphorylation site [posttranslational modification] 511145005277 metal binding site [ion binding]; metal-binding site 511145005278 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 511145005279 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 511145005280 active site 511145005281 P-loop; other site 511145005282 phosphorylation site [posttranslational modification] 511145005283 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 511145005284 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 511145005285 homodimer interface [polypeptide binding]; other site 511145005286 NAD binding pocket [chemical binding]; other site 511145005287 ATP binding pocket [chemical binding]; other site 511145005288 Mg binding site [ion binding]; other site 511145005289 active-site loop [active] 511145005290 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 511145005291 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 511145005292 GIY-YIG motif/motif A; other site 511145005293 active site 511145005294 catalytic site [active] 511145005295 putative DNA binding site [nucleotide binding]; other site 511145005296 metal binding site [ion binding]; metal-binding site 511145005297 hypothetical protein; Provisional; Region: PRK11396 511145005298 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 511145005299 dimer interface [polypeptide binding]; other site 511145005300 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 511145005301 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 511145005302 putative active site [active] 511145005303 Zn binding site [ion binding]; other site 511145005304 succinylarginine dihydrolase; Provisional; Region: PRK13281 511145005305 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 511145005306 NAD(P) binding site [chemical binding]; other site 511145005307 catalytic residues [active] 511145005308 arginine succinyltransferase; Provisional; Region: PRK10456 511145005309 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 511145005310 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511145005311 inhibitor-cofactor binding pocket; inhibition site 511145005312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145005313 catalytic residue [active] 511145005314 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 511145005315 putative catalytic site [active] 511145005316 putative phosphate binding site [ion binding]; other site 511145005317 active site 511145005318 metal binding site A [ion binding]; metal-binding site 511145005319 DNA binding site [nucleotide binding] 511145005320 putative AP binding site [nucleotide binding]; other site 511145005321 putative metal binding site B [ion binding]; other site 511145005322 Uncharacterized conserved protein [Function unknown]; Region: COG0398 511145005323 Uncharacterized conserved protein [Function unknown]; Region: COG0398 511145005324 Uncharacterized conserved protein [Function unknown]; Region: COG2128 511145005325 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 511145005326 hypothetical protein; Provisional; Region: PRK11622 511145005327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 511145005328 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 511145005329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145005330 putative PBP binding loops; other site 511145005331 ABC-ATPase subunit interface; other site 511145005332 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 511145005333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145005334 Walker A/P-loop; other site 511145005335 ATP binding site [chemical binding]; other site 511145005336 Q-loop/lid; other site 511145005337 ABC transporter signature motif; other site 511145005338 Walker B; other site 511145005339 D-loop; other site 511145005340 H-loop/switch region; other site 511145005341 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 511145005342 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 511145005343 active site residue [active] 511145005344 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 511145005345 active site residue [active] 511145005346 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 511145005347 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 511145005348 active site 511145005349 8-oxo-dGMP binding site [chemical binding]; other site 511145005350 nudix motif; other site 511145005351 metal binding site [ion binding]; metal-binding site 511145005352 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 511145005353 glutamate dehydrogenase; Provisional; Region: PRK09414 511145005354 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 511145005355 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 511145005356 NAD(P) binding site [chemical binding]; other site 511145005357 hypothetical protein; Provisional; Region: PRK11380 511145005358 DNA topoisomerase III; Provisional; Region: PRK07726 511145005359 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 511145005360 active site 511145005361 putative interdomain interaction site [polypeptide binding]; other site 511145005362 putative metal-binding site [ion binding]; other site 511145005363 putative nucleotide binding site [chemical binding]; other site 511145005364 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511145005365 domain I; other site 511145005366 DNA binding groove [nucleotide binding] 511145005367 phosphate binding site [ion binding]; other site 511145005368 domain II; other site 511145005369 domain III; other site 511145005370 nucleotide binding site [chemical binding]; other site 511145005371 catalytic site [active] 511145005372 domain IV; other site 511145005373 selenophosphate synthetase; Provisional; Region: PRK00943 511145005374 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 511145005375 dimerization interface [polypeptide binding]; other site 511145005376 putative ATP binding site [chemical binding]; other site 511145005377 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 511145005378 putative FMN binding site [chemical binding]; other site 511145005379 protease 4; Provisional; Region: PRK10949 511145005380 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 511145005381 tandem repeat interface [polypeptide binding]; other site 511145005382 oligomer interface [polypeptide binding]; other site 511145005383 active site residues [active] 511145005384 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 511145005385 tandem repeat interface [polypeptide binding]; other site 511145005386 oligomer interface [polypeptide binding]; other site 511145005387 active site residues [active] 511145005388 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 511145005389 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 511145005390 active site 511145005391 homodimer interface [polypeptide binding]; other site 511145005392 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 511145005393 catalytic triad [active] 511145005394 metal binding site [ion binding]; metal-binding site 511145005395 conserved cis-peptide bond; other site 511145005396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145005397 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 511145005398 putative substrate translocation pore; other site 511145005399 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511145005400 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 511145005401 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145005402 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511145005403 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 511145005404 active site 511145005405 catalytic tetrad [active] 511145005406 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 511145005407 substrate binding site [chemical binding]; other site 511145005408 ATP binding site [chemical binding]; other site 511145005409 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 511145005410 intersubunit interface [polypeptide binding]; other site 511145005411 active site 511145005412 zinc binding site [ion binding]; other site 511145005413 Na+ binding site [ion binding]; other site 511145005414 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511145005415 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 511145005416 inhibitor binding site; inhibition site 511145005417 catalytic Zn binding site [ion binding]; other site 511145005418 structural Zn binding site [ion binding]; other site 511145005419 NADP binding site [chemical binding]; other site 511145005420 tetramer interface [polypeptide binding]; other site 511145005421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145005422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511145005423 putative substrate translocation pore; other site 511145005424 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511145005425 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 511145005426 putative NAD(P) binding site [chemical binding]; other site 511145005427 catalytic Zn binding site [ion binding]; other site 511145005428 structural Zn binding site [ion binding]; other site 511145005429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 511145005430 methionine sulfoxide reductase B; Provisional; Region: PRK00222 511145005431 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 511145005432 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 511145005433 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 511145005434 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 511145005435 active site 511145005436 phosphate binding residues; other site 511145005437 catalytic residues [active] 511145005438 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511145005439 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 511145005440 active site 511145005441 catalytic tetrad [active] 511145005442 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 511145005443 PrkA family serine protein kinase; Provisional; Region: PRK15455 511145005444 PrkA AAA domain; Region: AAA_PrkA; pfam08298 511145005445 Walker A motif; other site 511145005446 ATP binding site [chemical binding]; other site 511145005447 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 511145005448 Uncharacterized conserved protein [Function unknown]; Region: COG2718 511145005449 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 511145005450 metal ion-dependent adhesion site (MIDAS); other site 511145005451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145005452 metal binding site [ion binding]; metal-binding site 511145005453 active site 511145005454 I-site; other site 511145005455 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145005456 metal binding site [ion binding]; metal-binding site 511145005457 active site 511145005458 I-site; other site 511145005459 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 511145005460 putative deacylase active site [active] 511145005461 Predicted membrane protein [Function unknown]; Region: COG2707 511145005462 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511145005463 cyanate transporter; Region: CynX; TIGR00896 511145005464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145005465 putative substrate translocation pore; other site 511145005466 Uncharacterized conserved protein [Function unknown]; Region: COG3189 511145005467 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 511145005468 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 511145005469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145005470 metal binding site [ion binding]; metal-binding site 511145005471 active site 511145005472 I-site; other site 511145005473 hypothetical protein; Provisional; Region: PRK14760 511145005474 hypothetical protein; Provisional; Region: PRK10457 511145005475 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 511145005476 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 511145005477 leucine export protein LeuE; Provisional; Region: PRK10958 511145005478 transcriptional activator TtdR; Provisional; Region: PRK09801 511145005479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145005480 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 511145005481 putative effector binding pocket; other site 511145005482 putative dimerization interface [polypeptide binding]; other site 511145005483 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 511145005484 putative transporter; Provisional; Region: PRK09950 511145005485 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 511145005486 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 511145005487 [2Fe-2S] cluster binding site [ion binding]; other site 511145005488 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 511145005489 putative alpha subunit interface [polypeptide binding]; other site 511145005490 putative active site [active] 511145005491 putative substrate binding site [chemical binding]; other site 511145005492 Fe binding site [ion binding]; other site 511145005493 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 511145005494 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 511145005495 FMN-binding pocket [chemical binding]; other site 511145005496 flavin binding motif; other site 511145005497 phosphate binding motif [ion binding]; other site 511145005498 beta-alpha-beta structure motif; other site 511145005499 NAD binding pocket [chemical binding]; other site 511145005500 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511145005501 catalytic loop [active] 511145005502 iron binding site [ion binding]; other site 511145005503 ribonuclease D; Provisional; Region: PRK10829 511145005504 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 511145005505 catalytic site [active] 511145005506 putative active site [active] 511145005507 putative substrate binding site [chemical binding]; other site 511145005508 Helicase and RNase D C-terminal; Region: HRDC; smart00341 511145005509 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 511145005510 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 511145005511 acyl-activating enzyme (AAE) consensus motif; other site 511145005512 putative AMP binding site [chemical binding]; other site 511145005513 putative active site [active] 511145005514 putative CoA binding site [chemical binding]; other site 511145005515 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 511145005516 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 511145005517 Glycoprotease family; Region: Peptidase_M22; pfam00814 511145005518 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 511145005519 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 511145005520 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 511145005521 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 511145005522 homotrimer interaction site [polypeptide binding]; other site 511145005523 putative active site [active] 511145005524 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 511145005525 hypothetical protein; Provisional; Region: PRK05114 511145005526 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 511145005527 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 511145005528 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 511145005529 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 511145005530 putative active site [active] 511145005531 putative CoA binding site [chemical binding]; other site 511145005532 nudix motif; other site 511145005533 metal binding site [ion binding]; metal-binding site 511145005534 L-serine deaminase; Provisional; Region: PRK15023 511145005535 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 511145005536 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 511145005537 phage resistance protein; Provisional; Region: PRK10551 511145005538 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 511145005539 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145005540 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 511145005541 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 511145005542 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511145005543 Transporter associated domain; Region: CorC_HlyC; smart01091 511145005544 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 511145005545 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 511145005546 active pocket/dimerization site; other site 511145005547 active site 511145005548 phosphorylation site [posttranslational modification] 511145005549 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 511145005550 active site 511145005551 phosphorylation site [posttranslational modification] 511145005552 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 511145005553 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 511145005554 hypothetical protein; Provisional; Region: PRK02913 511145005555 hypothetical protein; Provisional; Region: PRK11469 511145005556 Domain of unknown function DUF; Region: DUF204; pfam02659 511145005557 Domain of unknown function DUF; Region: DUF204; pfam02659 511145005558 Methyltransferase domain; Region: Methyltransf_31; pfam13847 511145005559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145005560 S-adenosylmethionine binding site [chemical binding]; other site 511145005561 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511145005562 DNA-binding site [nucleotide binding]; DNA binding site 511145005563 RNA-binding motif; other site 511145005564 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 511145005565 YebO-like protein; Region: YebO; pfam13974 511145005566 PhoPQ regulatory protein; Provisional; Region: PRK10299 511145005567 YobH-like protein; Region: YobH; pfam13996 511145005568 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 511145005569 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511145005570 dimerization interface [polypeptide binding]; other site 511145005571 putative Zn2+ binding site [ion binding]; other site 511145005572 putative DNA binding site [nucleotide binding]; other site 511145005573 Bacterial transcriptional regulator; Region: IclR; pfam01614 511145005574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145005575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511145005576 putative substrate translocation pore; other site 511145005577 Predicted integral membrane protein [Function unknown]; Region: COG5521 511145005578 heat shock protein HtpX; Provisional; Region: PRK05457 511145005579 carboxy-terminal protease; Provisional; Region: PRK11186 511145005580 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 511145005581 protein binding site [polypeptide binding]; other site 511145005582 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 511145005583 Catalytic dyad [active] 511145005584 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 511145005585 ProP expression regulator; Provisional; Region: PRK04950 511145005586 putative RNA binding sites [nucleotide binding]; other site 511145005587 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 511145005588 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 511145005589 Paraquat-inducible protein A; Region: PqiA; pfam04403 511145005590 Paraquat-inducible protein A; Region: PqiA; pfam04403 511145005591 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 511145005592 mce related protein; Region: MCE; pfam02470 511145005593 mce related protein; Region: MCE; pfam02470 511145005594 mce related protein; Region: MCE; pfam02470 511145005595 mce related protein; Region: MCE; pfam02470 511145005596 mce related protein; Region: MCE; pfam02470 511145005597 mce related protein; Region: MCE; pfam02470 511145005598 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 511145005599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145005600 S-adenosylmethionine binding site [chemical binding]; other site 511145005601 Uncharacterized conserved protein [Function unknown]; Region: COG3270 511145005602 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 511145005603 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 511145005604 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 511145005605 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 511145005606 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 511145005607 hypothetical protein; Provisional; Region: PRK10301 511145005608 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 511145005609 Predicted amidohydrolase [General function prediction only]; Region: COG0388 511145005610 exodeoxyribonuclease X; Provisional; Region: PRK07983 511145005611 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511145005612 active site 511145005613 catalytic site [active] 511145005614 substrate binding site [chemical binding]; other site 511145005615 protease 2; Provisional; Region: PRK10115 511145005616 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 511145005617 Protein of unknown function (DUF533); Region: DUF533; pfam04391 511145005618 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 511145005619 putative metal binding site [ion binding]; other site 511145005620 hypothetical protein; Provisional; Region: PRK13680 511145005621 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 511145005622 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 511145005623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511145005624 ATP-grasp domain; Region: ATP-grasp; pfam02222 511145005625 Entner-Doudoroff aldolase; Region: eda; TIGR01182 511145005626 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 511145005627 active site 511145005628 intersubunit interface [polypeptide binding]; other site 511145005629 catalytic residue [active] 511145005630 phosphogluconate dehydratase; Validated; Region: PRK09054 511145005631 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 511145005632 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 511145005633 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 511145005634 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 511145005635 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 511145005636 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 511145005637 putative active site [active] 511145005638 pyruvate kinase; Provisional; Region: PRK05826 511145005639 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 511145005640 domain interfaces; other site 511145005641 active site 511145005642 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 511145005643 putative acyl-acceptor binding pocket; other site 511145005644 putative peptidase; Provisional; Region: PRK11649 511145005645 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 511145005646 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511145005647 Peptidase family M23; Region: Peptidase_M23; pfam01551 511145005648 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 511145005649 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 511145005650 metal binding site [ion binding]; metal-binding site 511145005651 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 511145005652 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 511145005653 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511145005654 ABC-ATPase subunit interface; other site 511145005655 dimer interface [polypeptide binding]; other site 511145005656 putative PBP binding regions; other site 511145005657 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 511145005658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145005659 Walker A motif; other site 511145005660 ATP binding site [chemical binding]; other site 511145005661 Walker B motif; other site 511145005662 arginine finger; other site 511145005663 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 511145005664 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 511145005665 RuvA N terminal domain; Region: RuvA_N; pfam01330 511145005666 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 511145005667 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 511145005668 hypothetical protein; Provisional; Region: PRK11470 511145005669 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 511145005670 active site 511145005671 putative DNA-binding cleft [nucleotide binding]; other site 511145005672 dimer interface [polypeptide binding]; other site 511145005673 hypothetical protein; Validated; Region: PRK00110 511145005674 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 511145005675 nudix motif; other site 511145005676 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 511145005677 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 511145005678 dimer interface [polypeptide binding]; other site 511145005679 anticodon binding site; other site 511145005680 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 511145005681 homodimer interface [polypeptide binding]; other site 511145005682 motif 1; other site 511145005683 active site 511145005684 motif 2; other site 511145005685 GAD domain; Region: GAD; pfam02938 511145005686 motif 3; other site 511145005687 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511145005688 catalytic triad [active] 511145005689 conserved cis-peptide bond; other site 511145005690 hypothetical protein; Provisional; Region: PRK10302 511145005691 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 511145005692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145005693 S-adenosylmethionine binding site [chemical binding]; other site 511145005694 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 511145005695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145005696 S-adenosylmethionine binding site [chemical binding]; other site 511145005697 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 511145005698 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 511145005699 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 511145005700 molybdopterin cofactor binding site [chemical binding]; other site 511145005701 substrate binding site [chemical binding]; other site 511145005702 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 511145005703 molybdopterin cofactor binding site; other site 511145005704 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 511145005705 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 511145005706 copper homeostasis protein CutC; Provisional; Region: PRK11572 511145005707 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 511145005708 putative metal binding site [ion binding]; other site 511145005709 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 511145005710 arginyl-tRNA synthetase; Region: argS; TIGR00456 511145005711 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 511145005712 active site 511145005713 HIGH motif; other site 511145005714 KMSK motif region; other site 511145005715 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 511145005716 tRNA binding surface [nucleotide binding]; other site 511145005717 anticodon binding site; other site 511145005718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 511145005719 Flagellar protein FlhE; Region: FlhE; pfam06366 511145005720 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 511145005721 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 511145005722 chemotaxis regulator CheZ; Provisional; Region: PRK11166 511145005723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145005724 active site 511145005725 phosphorylation site [posttranslational modification] 511145005726 intermolecular recognition site; other site 511145005727 dimerization interface [polypeptide binding]; other site 511145005728 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 511145005729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145005730 active site 511145005731 phosphorylation site [posttranslational modification] 511145005732 intermolecular recognition site; other site 511145005733 dimerization interface [polypeptide binding]; other site 511145005734 CheB methylesterase; Region: CheB_methylest; pfam01339 511145005735 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 511145005736 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 511145005737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145005738 S-adenosylmethionine binding site [chemical binding]; other site 511145005739 methyl-accepting protein IV; Provisional; Region: PRK09793 511145005740 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 511145005741 dimer interface [polypeptide binding]; other site 511145005742 ligand binding site [chemical binding]; other site 511145005743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145005744 dimerization interface [polypeptide binding]; other site 511145005745 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 511145005746 dimer interface [polypeptide binding]; other site 511145005747 putative CheW interface [polypeptide binding]; other site 511145005748 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 511145005749 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 511145005750 dimer interface [polypeptide binding]; other site 511145005751 ligand binding site [chemical binding]; other site 511145005752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145005753 dimerization interface [polypeptide binding]; other site 511145005754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 511145005755 dimer interface [polypeptide binding]; other site 511145005756 putative CheW interface [polypeptide binding]; other site 511145005757 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 511145005758 putative CheA interaction surface; other site 511145005759 chemotaxis protein CheA; Provisional; Region: PRK10547 511145005760 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 511145005761 putative binding surface; other site 511145005762 active site 511145005763 CheY binding; Region: CheY-binding; pfam09078 511145005764 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 511145005765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145005766 ATP binding site [chemical binding]; other site 511145005767 Mg2+ binding site [ion binding]; other site 511145005768 G-X-G motif; other site 511145005769 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 511145005770 flagellar motor protein MotB; Validated; Region: motB; PRK09041 511145005771 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 511145005772 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 511145005773 ligand binding site [chemical binding]; other site 511145005774 flagellar motor protein MotA; Validated; Region: PRK09110 511145005775 transcriptional activator FlhC; Provisional; Region: PRK12722 511145005776 transcriptional activator FlhD; Provisional; Region: PRK02909 511145005777 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 511145005778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 511145005779 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 511145005780 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 511145005781 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511145005782 Ligand Binding Site [chemical binding]; other site 511145005783 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 511145005784 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 511145005785 active site 511145005786 homotetramer interface [polypeptide binding]; other site 511145005787 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 511145005788 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 511145005789 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145005790 TM-ABC transporter signature motif; other site 511145005791 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 511145005792 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511145005793 Walker A/P-loop; other site 511145005794 ATP binding site [chemical binding]; other site 511145005795 Q-loop/lid; other site 511145005796 ABC transporter signature motif; other site 511145005797 Walker B; other site 511145005798 D-loop; other site 511145005799 H-loop/switch region; other site 511145005800 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511145005801 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 511145005802 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 511145005803 ligand binding site [chemical binding]; other site 511145005804 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 511145005805 Ferritin-like domain; Region: Ferritin; pfam00210 511145005806 ferroxidase diiron center [ion binding]; other site 511145005807 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 511145005808 YecR-like lipoprotein; Region: YecR; pfam13992 511145005809 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 511145005810 Ferritin-like domain; Region: Ferritin; pfam00210 511145005811 ferroxidase diiron center [ion binding]; other site 511145005812 probable metal-binding protein; Region: matur_matur; TIGR03853 511145005813 tyrosine transporter TyrP; Provisional; Region: PRK15132 511145005814 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 511145005815 hypothetical protein; Provisional; Region: PRK10396 511145005816 yecA family protein; Region: ygfB_yecA; TIGR02292 511145005817 SEC-C motif; Region: SEC-C; cl19389 511145005818 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 511145005819 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 511145005820 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 511145005821 GIY-YIG motif/motif A; other site 511145005822 active site 511145005823 catalytic site [active] 511145005824 putative DNA binding site [nucleotide binding]; other site 511145005825 metal binding site [ion binding]; metal-binding site 511145005826 UvrB/uvrC motif; Region: UVR; pfam02151 511145005827 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 511145005828 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 511145005829 response regulator; Provisional; Region: PRK09483 511145005830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145005831 active site 511145005832 phosphorylation site [posttranslational modification] 511145005833 intermolecular recognition site; other site 511145005834 dimerization interface [polypeptide binding]; other site 511145005835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145005836 DNA binding residues [nucleotide binding] 511145005837 dimerization interface [polypeptide binding]; other site 511145005838 hypothetical protein; Provisional; Region: PRK10613 511145005839 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 511145005840 Autoinducer binding domain; Region: Autoind_bind; pfam03472 511145005841 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145005842 DNA binding residues [nucleotide binding] 511145005843 dimerization interface [polypeptide binding]; other site 511145005844 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 511145005845 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511145005846 Walker A/P-loop; other site 511145005847 ATP binding site [chemical binding]; other site 511145005848 Q-loop/lid; other site 511145005849 ABC transporter signature motif; other site 511145005850 Walker B; other site 511145005851 D-loop; other site 511145005852 H-loop/switch region; other site 511145005853 amino acid ABC transporter permease; Provisional; Region: PRK15100 511145005854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145005855 dimer interface [polypeptide binding]; other site 511145005856 conserved gate region; other site 511145005857 putative PBP binding loops; other site 511145005858 ABC-ATPase subunit interface; other site 511145005859 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 511145005860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145005861 catalytic residue [active] 511145005862 cystine transporter subunit; Provisional; Region: PRK11260 511145005863 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145005864 substrate binding pocket [chemical binding]; other site 511145005865 membrane-bound complex binding site; other site 511145005866 hinge residues; other site 511145005867 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 511145005868 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 511145005869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511145005870 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 511145005871 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511145005872 DNA binding residues [nucleotide binding] 511145005873 flagellin; Validated; Region: PRK08026 511145005874 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 511145005875 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 511145005876 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 511145005877 flagellar capping protein; Reviewed; Region: fliD; PRK08032 511145005878 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 511145005879 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 511145005880 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 511145005881 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 511145005882 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 511145005883 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 511145005884 active site 511145005885 Na/Ca binding site [ion binding]; other site 511145005886 catalytic site [active] 511145005887 lipoprotein; Provisional; Region: PRK10397 511145005888 putative inner membrane protein; Provisional; Region: PRK11099 511145005889 Predicted transporter component [General function prediction only]; Region: COG2391 511145005890 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 511145005891 CPxP motif; other site 511145005892 hypothetical protein; Provisional; Region: PRK09951 511145005893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511145005894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145005895 Coenzyme A binding pocket [chemical binding]; other site 511145005896 flagellar hook-basal body complex protein FliE; Region: fliE; TIGR00205 511145005897 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 511145005898 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 511145005899 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 511145005900 flagellar motor switch protein FliG; Region: fliG; TIGR00207 511145005901 FliG N-terminal domain; Region: FliG_N; pfam14842 511145005902 FliG middle domain; Region: FliG_M; pfam14841 511145005903 FliG C-terminal domain; Region: FliG_C; pfam01706 511145005904 flagellar assembly protein H; Validated; Region: fliH; PRK05687 511145005905 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 511145005906 Flagellar assembly protein FliH; Region: FliH; pfam02108 511145005907 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 511145005908 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 511145005909 Walker A motif/ATP binding site; other site 511145005910 Walker B motif; other site 511145005911 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 511145005912 flagellar hook-length control protein; Provisional; Region: PRK10118 511145005913 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 511145005914 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 511145005915 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 511145005916 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 511145005917 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 511145005918 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 511145005919 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 511145005920 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 511145005921 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 511145005922 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 511145005923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145005924 DNA binding residues [nucleotide binding] 511145005925 dimerization interface [polypeptide binding]; other site 511145005926 hypothetical protein; Provisional; Region: PRK10708 511145005927 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 511145005928 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 511145005929 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 511145005930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145005931 active site 511145005932 motif I; other site 511145005933 motif II; other site 511145005934 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 511145005935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145005936 metal binding site [ion binding]; metal-binding site 511145005937 active site 511145005938 I-site; other site 511145005939 Uncharacterized small protein [Function unknown]; Region: COG5475 511145005940 hypothetical protein; Provisional; Region: PRK10062 511145005941 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 511145005942 EamA-like transporter family; Region: EamA; pfam00892 511145005943 EamA-like transporter family; Region: EamA; pfam00892 511145005944 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 511145005945 additional DNA contacts [nucleotide binding]; other site 511145005946 mismatch recognition site; other site 511145005947 active site 511145005948 zinc binding site [ion binding]; other site 511145005949 DNA intercalation site [nucleotide binding]; other site 511145005950 DNA cytosine methylase; Provisional; Region: PRK10458 511145005951 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 511145005952 cofactor binding site; other site 511145005953 DNA binding site [nucleotide binding] 511145005954 substrate interaction site [chemical binding]; other site 511145005955 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 511145005956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511145005957 Zn2+ binding site [ion binding]; other site 511145005958 Mg2+ binding site [ion binding]; other site 511145005959 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 511145005960 chaperone protein HchA; Provisional; Region: PRK04155 511145005961 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 511145005962 dimer interface [polypeptide binding]; other site 511145005963 metal binding site [ion binding]; metal-binding site 511145005964 potential oxyanion hole; other site 511145005965 potential catalytic triad [active] 511145005966 conserved cys residue [active] 511145005967 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 511145005968 HAMP domain; Region: HAMP; pfam00672 511145005969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145005970 dimer interface [polypeptide binding]; other site 511145005971 phosphorylation site [posttranslational modification] 511145005972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145005973 ATP binding site [chemical binding]; other site 511145005974 Mg2+ binding site [ion binding]; other site 511145005975 G-X-G motif; other site 511145005976 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 511145005977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145005978 active site 511145005979 phosphorylation site [posttranslational modification] 511145005980 intermolecular recognition site; other site 511145005981 dimerization interface [polypeptide binding]; other site 511145005982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145005983 DNA binding site [nucleotide binding] 511145005984 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 511145005985 active site 511145005986 homotetramer interface [polypeptide binding]; other site 511145005987 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 511145005988 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 511145005989 Moco binding site; other site 511145005990 metal coordination site [ion binding]; other site 511145005991 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 511145005992 zinc/cadmium-binding protein; Provisional; Region: PRK10306 511145005993 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 511145005994 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 511145005995 putative invasin; Provisional; Region: PRK10177 511145005996 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 511145005997 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 511145005998 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145005999 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145006000 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 511145006001 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 511145006002 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145006003 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145006004 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145006005 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145006006 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145006007 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145006008 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145006009 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 511145006010 shikimate transporter; Provisional; Region: PRK09952 511145006011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145006012 putative substrate translocation pore; other site 511145006013 AMP nucleosidase; Provisional; Region: PRK08292 511145006014 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 511145006015 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 511145006016 hypothetical protein; Provisional; Region: PRK12378 511145006017 MATE family multidrug exporter; Provisional; Region: PRK10189 511145006018 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 511145006019 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 511145006020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145006021 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 511145006022 putative substrate binding site [chemical binding]; other site 511145006023 dimerization interface [polypeptide binding]; other site 511145006024 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 511145006025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145006026 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 511145006027 putative dimerization interface [polypeptide binding]; other site 511145006028 L,D-transpeptidase; Provisional; Region: PRK10190 511145006029 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 511145006030 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 511145006031 putative dimer interface [polypeptide binding]; other site 511145006032 active site pocket [active] 511145006033 putative cataytic base [active] 511145006034 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 511145006035 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 511145006036 homotrimer interface [polypeptide binding]; other site 511145006037 Walker A motif; other site 511145006038 GTP binding site [chemical binding]; other site 511145006039 Walker B motif; other site 511145006040 Transposase domain (DUF772); Region: DUF772; pfam05598 511145006041 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145006042 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145006043 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145006044 cryptic prophage CP4-44 511145006045 IS2 transposase TnpB; Reviewed; Region: PRK09409 511145006046 HTH-like domain; Region: HTH_21; pfam13276 511145006047 Integrase core domain; Region: rve; pfam00665 511145006048 Integrase core domain; Region: rve_3; pfam13683 511145006049 IS2 repressor TnpA; Reviewed; Region: PRK09413 511145006050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145006051 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 511145006052 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 511145006053 hypothetical protein; Provisional; Region: PRK09945 511145006054 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 511145006055 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 511145006056 Autotransporter beta-domain; Region: Autotransporter; smart00869 511145006057 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 511145006058 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 511145006059 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 511145006060 MPN+ (JAMM) motif; other site 511145006061 Zinc-binding site [ion binding]; other site 511145006062 Protein of unknown function (DUF987); Region: DUF987; pfam06174 511145006063 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 511145006064 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 511145006065 hypothetical protein; Provisional; Region: PRK05423 511145006066 Predicted membrane protein [Function unknown]; Region: COG1289 511145006067 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 511145006068 DNA gyrase inhibitor; Provisional; Region: PRK10016 511145006069 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 511145006070 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 511145006071 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 511145006072 exonuclease I; Provisional; Region: sbcB; PRK11779 511145006073 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 511145006074 active site 511145006075 catalytic site [active] 511145006076 substrate binding site [chemical binding]; other site 511145006077 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 511145006078 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 511145006079 CPxP motif; other site 511145006080 Predicted transporter component [General function prediction only]; Region: COG2391 511145006081 Sulphur transport; Region: Sulf_transp; cl19477 511145006082 Sulphur transport; Region: Sulf_transp; cl19477 511145006083 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 511145006084 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145006085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145006086 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 511145006087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145006088 dimerization interface [polypeptide binding]; other site 511145006089 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 511145006090 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 511145006091 putative NAD(P) binding site [chemical binding]; other site 511145006092 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 511145006093 antitoxin YefM; Provisional; Region: PRK11409 511145006094 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 511145006095 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 511145006096 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 511145006097 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 511145006098 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 511145006099 NAD binding site [chemical binding]; other site 511145006100 dimerization interface [polypeptide binding]; other site 511145006101 product binding site; other site 511145006102 substrate binding site [chemical binding]; other site 511145006103 zinc binding site [ion binding]; other site 511145006104 catalytic residues [active] 511145006105 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 511145006106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145006107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145006108 homodimer interface [polypeptide binding]; other site 511145006109 catalytic residue [active] 511145006110 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 511145006111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145006112 active site 511145006113 motif I; other site 511145006114 motif II; other site 511145006115 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 511145006116 putative active site pocket [active] 511145006117 4-fold oligomerization interface [polypeptide binding]; other site 511145006118 metal binding residues [ion binding]; metal-binding site 511145006119 3-fold/trimer interface [polypeptide binding]; other site 511145006120 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 511145006121 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 511145006122 putative active site [active] 511145006123 oxyanion strand; other site 511145006124 catalytic triad [active] 511145006125 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 511145006126 catalytic residues [active] 511145006127 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 511145006128 substrate binding site [chemical binding]; other site 511145006129 glutamase interaction surface [polypeptide binding]; other site 511145006130 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 511145006131 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 511145006132 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 511145006133 metal binding site [ion binding]; metal-binding site 511145006134 chain length determinant protein WzzB; Provisional; Region: PRK15471 511145006135 Chain length determinant protein; Region: Wzz; pfam02706 511145006136 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 511145006137 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 511145006138 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 511145006139 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 511145006140 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 511145006141 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 511145006142 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 511145006143 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 511145006144 Transposase domain (DUF772); Region: DUF772; pfam05598 511145006145 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145006146 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145006147 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145006148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511145006149 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 511145006150 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 511145006151 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 511145006152 trimer interface [polypeptide binding]; other site 511145006153 active site 511145006154 substrate binding site [chemical binding]; other site 511145006155 CoA binding site [chemical binding]; other site 511145006156 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 511145006157 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 511145006158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 511145006159 UDP-galactopyranose mutase; Region: GLF; pfam03275 511145006160 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 511145006161 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 511145006162 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 511145006163 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 511145006164 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 511145006165 substrate binding site; other site 511145006166 tetramer interface; other site 511145006167 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 511145006168 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 511145006169 NADP binding site [chemical binding]; other site 511145006170 active site 511145006171 putative substrate binding site [chemical binding]; other site 511145006172 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 511145006173 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 511145006174 NAD binding site [chemical binding]; other site 511145006175 substrate binding site [chemical binding]; other site 511145006176 homodimer interface [polypeptide binding]; other site 511145006177 active site 511145006178 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 511145006179 active site 511145006180 tetramer interface; other site 511145006181 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 511145006182 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 511145006183 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 511145006184 putative ADP-binding pocket [chemical binding]; other site 511145006185 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 511145006186 colanic acid exporter; Provisional; Region: PRK10459 511145006187 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 511145006188 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 511145006189 CoA-binding domain; Region: CoA_binding_3; pfam13727 511145006190 Bacterial sugar transferase; Region: Bac_transf; pfam02397 511145006191 phosphomannomutase CpsG; Provisional; Region: PRK15414 511145006192 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 511145006193 active site 511145006194 substrate binding site [chemical binding]; other site 511145006195 metal binding site [ion binding]; metal-binding site 511145006196 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 511145006197 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 511145006198 Substrate binding site; other site 511145006199 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 511145006200 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 511145006201 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 511145006202 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 511145006203 active site 511145006204 GDP-Mannose binding site [chemical binding]; other site 511145006205 dimer interface [polypeptide binding]; other site 511145006206 modified nudix motif 511145006207 metal binding site [ion binding]; metal-binding site 511145006208 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 511145006209 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 511145006210 NADP binding site [chemical binding]; other site 511145006211 active site 511145006212 putative substrate binding site [chemical binding]; other site 511145006213 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 511145006214 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 511145006215 NADP-binding site; other site 511145006216 homotetramer interface [polypeptide binding]; other site 511145006217 substrate binding site [chemical binding]; other site 511145006218 homodimer interface [polypeptide binding]; other site 511145006219 active site 511145006220 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 511145006221 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 511145006222 putative trimer interface [polypeptide binding]; other site 511145006223 putative active site [active] 511145006224 putative substrate binding site [chemical binding]; other site 511145006225 putative CoA binding site [chemical binding]; other site 511145006226 putative glycosyl transferase; Provisional; Region: PRK10063 511145006227 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 511145006228 metal-binding site 511145006229 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 511145006230 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 511145006231 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 511145006232 putative acyl transferase; Provisional; Region: PRK10191 511145006233 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 511145006234 trimer interface [polypeptide binding]; other site 511145006235 active site 511145006236 substrate binding site [chemical binding]; other site 511145006237 CoA binding site [chemical binding]; other site 511145006238 putative glycosyl transferase; Provisional; Region: PRK10018 511145006239 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 511145006240 active site 511145006241 tyrosine kinase; Provisional; Region: PRK11519 511145006242 Chain length determinant protein; Region: Wzz; pfam02706 511145006243 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 511145006244 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511145006245 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511145006246 active site 511145006247 polysaccharide export protein Wza; Provisional; Region: PRK15078 511145006248 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 511145006249 SLBB domain; Region: SLBB; pfam10531 511145006250 SLBB domain; Region: SLBB; pfam10531 511145006251 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 511145006252 FOG: CBS domain [General function prediction only]; Region: COG0517 511145006253 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511145006254 Transporter associated domain; Region: CorC_HlyC; smart01091 511145006255 putative assembly protein; Provisional; Region: PRK10833 511145006256 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 511145006257 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 511145006258 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 511145006259 trimer interface [polypeptide binding]; other site 511145006260 active site 511145006261 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 511145006262 ATP-binding site [chemical binding]; other site 511145006263 Sugar specificity; other site 511145006264 Pyrimidine base specificity; other site 511145006265 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 511145006266 putative diguanylate cyclase; Provisional; Region: PRK09776 511145006267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145006268 putative active site [active] 511145006269 heme pocket [chemical binding]; other site 511145006270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145006271 putative active site [active] 511145006272 heme pocket [chemical binding]; other site 511145006273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145006274 putative active site [active] 511145006275 heme pocket [chemical binding]; other site 511145006276 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145006277 metal binding site [ion binding]; metal-binding site 511145006278 active site 511145006279 I-site; other site 511145006280 Putative diguanylate phosphodiesterase; Region: EAL; smart00052 511145006281 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 511145006282 AlkA N-terminal domain; Region: AlkA_N; smart01009 511145006283 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511145006284 minor groove reading motif; other site 511145006285 helix-hairpin-helix signature motif; other site 511145006286 substrate binding pocket [chemical binding]; other site 511145006287 active site 511145006288 putative chaperone; Provisional; Region: PRK11678 511145006289 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 511145006290 nucleotide binding site [chemical binding]; other site 511145006291 putative NEF/HSP70 interaction site [polypeptide binding]; other site 511145006292 SBD interface [polypeptide binding]; other site 511145006293 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 511145006294 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 511145006295 substrate binding site [chemical binding]; other site 511145006296 activation loop (A-loop); other site 511145006297 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 511145006298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 511145006299 Protein phosphatase 2C; Region: PP2C_2; pfam13672 511145006300 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 511145006301 metal ion-dependent adhesion site (MIDAS); other site 511145006302 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 511145006303 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145006304 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145006305 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 511145006306 MMPL family; Region: MMPL; cl14618 511145006307 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 511145006308 MMPL family; Region: MMPL; cl14618 511145006309 MMPL family; Region: MMPL; cl14618 511145006310 putative transporter; Provisional; Region: PRK10504 511145006311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145006312 putative substrate translocation pore; other site 511145006313 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 511145006314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145006315 dimerization interface [polypeptide binding]; other site 511145006316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145006317 dimer interface [polypeptide binding]; other site 511145006318 phosphorylation site [posttranslational modification] 511145006319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145006320 ATP binding site [chemical binding]; other site 511145006321 Mg2+ binding site [ion binding]; other site 511145006322 G-X-G motif; other site 511145006323 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 511145006324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145006325 active site 511145006326 phosphorylation site [posttranslational modification] 511145006327 intermolecular recognition site; other site 511145006328 dimerization interface [polypeptide binding]; other site 511145006329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145006330 DNA binding site [nucleotide binding] 511145006331 Uncharacterized conserved protein [Function unknown]; Region: COG3422 511145006332 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 511145006333 putative protease; Provisional; Region: PRK15452 511145006334 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 511145006335 cryptic prophage PR-X 511145006336 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 511145006337 lipid kinase; Reviewed; Region: PRK13054 511145006338 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 511145006339 Transposase; Region: HTH_Tnp_1; cl17663 511145006340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145006341 putative transposase OrfB; Reviewed; Region: PHA02517 511145006342 HTH-like domain; Region: HTH_21; pfam13276 511145006343 Integrase core domain; Region: rve; pfam00665 511145006344 Integrase core domain; Region: rve_2; pfam13333 511145006345 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 511145006346 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 511145006347 putative NAD(P) binding site [chemical binding]; other site 511145006348 catalytic Zn binding site [ion binding]; other site 511145006349 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 511145006350 active site 511145006351 P-loop; other site 511145006352 phosphorylation site [posttranslational modification] 511145006353 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145006354 active site 511145006355 phosphorylation site [posttranslational modification] 511145006356 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 511145006357 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 511145006358 intersubunit interface [polypeptide binding]; other site 511145006359 active site 511145006360 zinc binding site [ion binding]; other site 511145006361 Na+ binding site [ion binding]; other site 511145006362 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 511145006363 putative active site; other site 511145006364 catalytic residue [active] 511145006365 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 511145006366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145006367 putative substrate translocation pore; other site 511145006368 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 511145006369 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 511145006370 substrate binding site [chemical binding]; other site 511145006371 ATP binding site [chemical binding]; other site 511145006372 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511145006373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145006374 DNA-binding site [nucleotide binding]; DNA binding site 511145006375 UTRA domain; Region: UTRA; pfam07702 511145006376 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 511145006377 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 511145006378 active site 511145006379 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 511145006380 dimer interface [polypeptide binding]; other site 511145006381 substrate binding site [chemical binding]; other site 511145006382 ATP binding site [chemical binding]; other site 511145006383 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 511145006384 substrate binding site [chemical binding]; other site 511145006385 multimerization interface [polypeptide binding]; other site 511145006386 ATP binding site [chemical binding]; other site 511145006387 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 511145006388 putative metal binding site [ion binding]; other site 511145006389 putative homodimer interface [polypeptide binding]; other site 511145006390 putative homotetramer interface [polypeptide binding]; other site 511145006391 putative homodimer-homodimer interface [polypeptide binding]; other site 511145006392 putative allosteric switch controlling residues; other site 511145006393 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 511145006394 Predicted integral membrane protein [Function unknown]; Region: COG5455 511145006395 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 511145006396 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 511145006397 PapC N-terminal domain; Region: PapC_N; pfam13954 511145006398 Outer membrane usher protein; Region: Usher; pfam00577 511145006399 PapC C-terminal domain; Region: PapC_C; pfam13953 511145006400 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 511145006401 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145006402 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145006403 Fimbrial protein; Region: Fimbrial; cl01416 511145006404 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 511145006405 antiporter inner membrane protein; Provisional; Region: PRK11670 511145006406 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 511145006407 Walker A motif; other site 511145006408 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 511145006409 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 511145006410 active site 511145006411 HIGH motif; other site 511145006412 KMSKS motif; other site 511145006413 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 511145006414 tRNA binding surface [nucleotide binding]; other site 511145006415 anticodon binding site; other site 511145006416 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 511145006417 dimer interface [polypeptide binding]; other site 511145006418 putative tRNA-binding site [nucleotide binding]; other site 511145006419 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 511145006420 MoxR-like ATPases [General function prediction only]; Region: COG0714 511145006421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145006422 Walker A motif; other site 511145006423 ATP binding site [chemical binding]; other site 511145006424 Walker B motif; other site 511145006425 arginine finger; other site 511145006426 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 511145006427 metal ion-dependent adhesion site (MIDAS); other site 511145006428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 511145006429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 511145006430 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 511145006431 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 511145006432 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 511145006433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145006434 active site 511145006435 phosphorylation site [posttranslational modification] 511145006436 intermolecular recognition site; other site 511145006437 dimerization interface [polypeptide binding]; other site 511145006438 LytTr DNA-binding domain; Region: LytTR; pfam04397 511145006439 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 511145006440 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 511145006441 GAF domain; Region: GAF; pfam01590 511145006442 Histidine kinase; Region: His_kinase; pfam06580 511145006443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145006444 ATP binding site [chemical binding]; other site 511145006445 Mg2+ binding site [ion binding]; other site 511145006446 G-X-G motif; other site 511145006447 transcriptional regulator MirA; Provisional; Region: PRK15043 511145006448 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 511145006449 DNA binding residues [nucleotide binding] 511145006450 hypothetical protein; Provisional; Region: PRK13681 511145006451 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 511145006452 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 511145006453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145006454 dimer interface [polypeptide binding]; other site 511145006455 conserved gate region; other site 511145006456 putative PBP binding loops; other site 511145006457 ABC-ATPase subunit interface; other site 511145006458 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 511145006459 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 511145006460 Walker A/P-loop; other site 511145006461 ATP binding site [chemical binding]; other site 511145006462 Q-loop/lid; other site 511145006463 ABC transporter signature motif; other site 511145006464 Walker B; other site 511145006465 D-loop; other site 511145006466 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 511145006467 H-loop/switch region; other site 511145006468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145006469 dimer interface [polypeptide binding]; other site 511145006470 conserved gate region; other site 511145006471 putative PBP binding loops; other site 511145006472 ABC-ATPase subunit interface; other site 511145006473 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 511145006474 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 511145006475 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 511145006476 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 511145006477 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 511145006478 D-lactate dehydrogenase; Provisional; Region: PRK11183 511145006479 FAD binding domain; Region: FAD_binding_4; cl19922 511145006480 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 511145006481 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 511145006482 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 511145006483 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 511145006484 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 511145006485 oxidoreductase; Provisional; Region: PRK12743 511145006486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511145006487 NAD(P) binding site [chemical binding]; other site 511145006488 active site 511145006489 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 511145006490 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 511145006491 FMN binding site [chemical binding]; other site 511145006492 active site 511145006493 catalytic residues [active] 511145006494 substrate binding site [chemical binding]; other site 511145006495 hypothetical protein; Provisional; Region: PRK01821 511145006496 hypothetical protein; Provisional; Region: PRK10711 511145006497 cytidine deaminase; Provisional; Region: PRK09027 511145006498 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 511145006499 active site 511145006500 catalytic motif [active] 511145006501 Zn binding site [ion binding]; other site 511145006502 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 511145006503 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 511145006504 active site 511145006505 catalytic motif [active] 511145006506 Zn binding site [ion binding]; other site 511145006507 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 511145006508 putative active site [active] 511145006509 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 511145006510 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 511145006511 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 511145006512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 511145006513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145006514 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 511145006515 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 511145006516 homodimer interface [polypeptide binding]; other site 511145006517 active site 511145006518 FMN binding site [chemical binding]; other site 511145006519 substrate binding site [chemical binding]; other site 511145006520 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145006521 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145006522 TM-ABC transporter signature motif; other site 511145006523 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511145006524 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 511145006525 Walker A/P-loop; other site 511145006526 ATP binding site [chemical binding]; other site 511145006527 Q-loop/lid; other site 511145006528 ABC transporter signature motif; other site 511145006529 Walker B; other site 511145006530 D-loop; other site 511145006531 H-loop/switch region; other site 511145006532 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511145006533 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 511145006534 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 511145006535 ligand binding site [chemical binding]; other site 511145006536 calcium binding site [ion binding]; other site 511145006537 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 511145006538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145006539 DNA binding site [nucleotide binding] 511145006540 domain linker motif; other site 511145006541 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 511145006542 dimerization interface (closed form) [polypeptide binding]; other site 511145006543 ligand binding site [chemical binding]; other site 511145006544 Predicted membrane protein [Function unknown]; Region: COG2311 511145006545 hypothetical protein; Provisional; Region: PRK10835 511145006546 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 511145006547 homodecamer interface [polypeptide binding]; other site 511145006548 active site 511145006549 putative catalytic site residues [active] 511145006550 zinc binding site [ion binding]; other site 511145006551 GTP-CH-I/GFRP interaction surface; other site 511145006552 Predicted esterase [General function prediction only]; Region: COG0627 511145006553 S-formylglutathione hydrolase; Region: PLN02442 511145006554 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 511145006555 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 511145006556 N-terminal plug; other site 511145006557 ligand-binding site [chemical binding]; other site 511145006558 lysine transporter; Provisional; Region: PRK10836 511145006559 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145006560 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 511145006561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145006562 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 511145006563 putative dimerization interface [polypeptide binding]; other site 511145006564 conserved hypothetical integral membrane protein; Region: TIGR00698 511145006565 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 511145006566 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 511145006567 AP (apurinic/apyrimidinic) site pocket; other site 511145006568 DNA interaction; other site 511145006569 Metal-binding active site; metal-binding site 511145006570 putative kinase; Provisional; Region: PRK09954 511145006571 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 511145006572 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 511145006573 substrate binding site [chemical binding]; other site 511145006574 ATP binding site [chemical binding]; other site 511145006575 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 511145006576 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 511145006577 Nucleoside recognition; Region: Gate; pfam07670 511145006578 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 511145006579 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 511145006580 active site 511145006581 tetramer interface [polypeptide binding]; other site 511145006582 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 511145006583 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 511145006584 ligand binding site [chemical binding]; other site 511145006585 flexible hinge region; other site 511145006586 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 511145006587 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 511145006588 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 511145006589 Nucleoside recognition; Region: Gate; pfam07670 511145006590 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 511145006591 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 511145006592 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 511145006593 substrate binding site [chemical binding]; other site 511145006594 ATP binding site [chemical binding]; other site 511145006595 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 511145006596 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 511145006597 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 511145006598 active site 511145006599 P-loop; other site 511145006600 phosphorylation site [posttranslational modification] 511145006601 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 511145006602 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 511145006603 putative substrate binding site [chemical binding]; other site 511145006604 putative ATP binding site [chemical binding]; other site 511145006605 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 511145006606 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145006607 active site 511145006608 phosphorylation site [posttranslational modification] 511145006609 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511145006610 dimerization domain swap beta strand [polypeptide binding]; other site 511145006611 regulatory protein interface [polypeptide binding]; other site 511145006612 active site 511145006613 regulatory phosphorylation site [posttranslational modification]; other site 511145006614 sugar efflux transporter B; Provisional; Region: PRK15011 511145006615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145006616 putative substrate translocation pore; other site 511145006617 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 511145006618 elongation factor P; Provisional; Region: PRK04542 511145006619 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 511145006620 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 511145006621 RNA binding site [nucleotide binding]; other site 511145006622 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 511145006623 RNA binding site [nucleotide binding]; other site 511145006624 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 511145006625 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 511145006626 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 511145006627 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 511145006628 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 511145006629 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 511145006630 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 511145006631 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 511145006632 active site 511145006633 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 511145006634 NlpC/P60 family; Region: NLPC_P60; pfam00877 511145006635 phage resistance protein; Provisional; Region: PRK10551 511145006636 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 511145006637 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145006638 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511145006639 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 511145006640 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 511145006641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145006642 dimer interface [polypeptide binding]; other site 511145006643 conserved gate region; other site 511145006644 putative PBP binding loops; other site 511145006645 ABC-ATPase subunit interface; other site 511145006646 microcin C ABC transporter permease; Provisional; Region: PRK15021 511145006647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145006648 dimer interface [polypeptide binding]; other site 511145006649 conserved gate region; other site 511145006650 putative PBP binding loops; other site 511145006651 ABC-ATPase subunit interface; other site 511145006652 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 511145006653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145006654 Walker A/P-loop; other site 511145006655 ATP binding site [chemical binding]; other site 511145006656 Q-loop/lid; other site 511145006657 ABC transporter signature motif; other site 511145006658 Walker B; other site 511145006659 D-loop; other site 511145006660 H-loop/switch region; other site 511145006661 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511145006662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145006663 Walker A/P-loop; other site 511145006664 ATP binding site [chemical binding]; other site 511145006665 Q-loop/lid; other site 511145006666 ABC transporter signature motif; other site 511145006667 Walker B; other site 511145006668 D-loop; other site 511145006669 H-loop/switch region; other site 511145006670 hypothetical protein; Provisional; Region: PRK11835 511145006671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145006672 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 511145006673 putative substrate translocation pore; other site 511145006674 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 511145006675 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511145006676 RNA binding surface [nucleotide binding]; other site 511145006677 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 511145006678 active site 511145006679 uracil binding [chemical binding]; other site 511145006680 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 511145006681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145006682 ATP binding site [chemical binding]; other site 511145006683 putative Mg++ binding site [ion binding]; other site 511145006684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145006685 nucleotide binding region [chemical binding]; other site 511145006686 ATP-binding site [chemical binding]; other site 511145006687 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 511145006688 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 511145006689 5S rRNA interface [nucleotide binding]; other site 511145006690 CTC domain interface [polypeptide binding]; other site 511145006691 L16 interface [polypeptide binding]; other site 511145006692 nucleoid-associated protein NdpA; Validated; Region: PRK00378 511145006693 hypothetical protein; Provisional; Region: PRK13689 511145006694 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 511145006695 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 511145006696 Sulfatase; Region: Sulfatase; pfam00884 511145006697 Transposase domain (DUF772); Region: DUF772; pfam05598 511145006698 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145006699 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145006700 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145006701 transcriptional regulator NarP; Provisional; Region: PRK10403 511145006702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145006703 active site 511145006704 phosphorylation site [posttranslational modification] 511145006705 intermolecular recognition site; other site 511145006706 dimerization interface [polypeptide binding]; other site 511145006707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145006708 DNA binding residues [nucleotide binding] 511145006709 dimerization interface [polypeptide binding]; other site 511145006710 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 511145006711 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 511145006712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145006713 binding surface 511145006714 TPR motif; other site 511145006715 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 511145006716 catalytic residues [active] 511145006717 central insert; other site 511145006718 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 511145006719 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 511145006720 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 511145006721 heme exporter protein CcmC; Region: ccmC; TIGR01191 511145006722 heme exporter protein CcmB; Region: ccmB; TIGR01190 511145006723 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 511145006724 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 511145006725 Walker A/P-loop; other site 511145006726 ATP binding site [chemical binding]; other site 511145006727 Q-loop/lid; other site 511145006728 ABC transporter signature motif; other site 511145006729 Walker B; other site 511145006730 D-loop; other site 511145006731 H-loop/switch region; other site 511145006732 cytochrome c-type protein NapC; Provisional; Region: PRK10617 511145006733 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 511145006734 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 511145006735 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 511145006736 4Fe-4S binding domain; Region: Fer4_5; pfam12801 511145006737 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145006738 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 511145006739 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145006740 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145006741 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145006742 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 511145006743 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 511145006744 [4Fe-4S] binding site [ion binding]; other site 511145006745 molybdopterin cofactor binding site; other site 511145006746 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 511145006747 molybdopterin cofactor binding site; other site 511145006748 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 511145006749 ferredoxin-type protein; Provisional; Region: PRK10194 511145006750 ferredoxin-type protein NapF; Region: napF; TIGR00402 511145006751 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 511145006752 secondary substrate binding site; other site 511145006753 primary substrate binding site; other site 511145006754 inhibition loop; other site 511145006755 dimerization interface [polypeptide binding]; other site 511145006756 malate:quinone oxidoreductase; Validated; Region: PRK05257 511145006757 Predicted dehydrogenase [General function prediction only]; Region: COG0579 511145006758 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 511145006759 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511145006760 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 511145006761 Walker A/P-loop; other site 511145006762 ATP binding site [chemical binding]; other site 511145006763 Q-loop/lid; other site 511145006764 ABC transporter signature motif; other site 511145006765 Walker B; other site 511145006766 D-loop; other site 511145006767 H-loop/switch region; other site 511145006768 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 511145006769 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 511145006770 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 511145006771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145006772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145006773 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 511145006774 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 511145006775 DNA binding site [nucleotide binding] 511145006776 active site 511145006777 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 511145006778 outer membrane porin protein C; Provisional; Region: PRK10554 511145006779 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 511145006780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145006781 ATP binding site [chemical binding]; other site 511145006782 Mg2+ binding site [ion binding]; other site 511145006783 G-X-G motif; other site 511145006784 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 511145006785 putative binding surface; other site 511145006786 active site 511145006787 transcriptional regulator RcsB; Provisional; Region: PRK10840 511145006788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145006789 active site 511145006790 phosphorylation site [posttranslational modification] 511145006791 intermolecular recognition site; other site 511145006792 dimerization interface [polypeptide binding]; other site 511145006793 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145006794 DNA binding residues [nucleotide binding] 511145006795 dimerization interface [polypeptide binding]; other site 511145006796 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 511145006797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145006798 dimer interface [polypeptide binding]; other site 511145006799 phosphorylation site [posttranslational modification] 511145006800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145006801 ATP binding site [chemical binding]; other site 511145006802 Mg2+ binding site [ion binding]; other site 511145006803 G-X-G motif; other site 511145006804 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 511145006805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145006806 active site 511145006807 phosphorylation site [posttranslational modification] 511145006808 intermolecular recognition site; other site 511145006809 dimerization interface [polypeptide binding]; other site 511145006810 sensory histidine kinase AtoS; Provisional; Region: PRK11360 511145006811 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145006812 putative active site [active] 511145006813 heme pocket [chemical binding]; other site 511145006814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145006815 dimer interface [polypeptide binding]; other site 511145006816 phosphorylation site [posttranslational modification] 511145006817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145006818 ATP binding site [chemical binding]; other site 511145006819 Mg2+ binding site [ion binding]; other site 511145006820 G-X-G motif; other site 511145006821 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 511145006822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145006823 active site 511145006824 phosphorylation site [posttranslational modification] 511145006825 intermolecular recognition site; other site 511145006826 dimerization interface [polypeptide binding]; other site 511145006827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145006828 Walker A motif; other site 511145006829 ATP binding site [chemical binding]; other site 511145006830 Walker B motif; other site 511145006831 arginine finger; other site 511145006832 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511145006833 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 511145006834 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 511145006835 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 511145006836 putative acyltransferase; Provisional; Region: PRK05790 511145006837 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 511145006838 dimer interface [polypeptide binding]; other site 511145006839 active site 511145006840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 511145006841 Predicted secreted protein [Function unknown]; Region: COG5445 511145006842 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 511145006843 Predicted secreted protein [Function unknown]; Region: COG5445 511145006844 Stage II sporulation protein; Region: SpoIID; pfam08486 511145006845 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 511145006846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 511145006847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 511145006848 DNA gyrase subunit A; Validated; Region: PRK05560 511145006849 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 511145006850 CAP-like domain; other site 511145006851 active site 511145006852 primary dimer interface [polypeptide binding]; other site 511145006853 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511145006854 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511145006855 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511145006856 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511145006857 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511145006858 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511145006859 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 511145006860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145006861 S-adenosylmethionine binding site [chemical binding]; other site 511145006862 adhesin; Provisional; Region: PRK09752 511145006863 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 511145006864 Autotransporter beta-domain; Region: Autotransporter; pfam03797 511145006865 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 511145006866 ATP cone domain; Region: ATP-cone; pfam03477 511145006867 Class I ribonucleotide reductase; Region: RNR_I; cd01679 511145006868 active site 511145006869 dimer interface [polypeptide binding]; other site 511145006870 catalytic residues [active] 511145006871 effector binding site; other site 511145006872 R2 peptide binding site; other site 511145006873 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 511145006874 dimer interface [polypeptide binding]; other site 511145006875 putative radical transfer pathway; other site 511145006876 diiron center [ion binding]; other site 511145006877 tyrosyl radical; other site 511145006878 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511145006879 catalytic loop [active] 511145006880 iron binding site [ion binding]; other site 511145006881 hypothetical protein; Provisional; Region: PRK09902 511145006882 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 511145006883 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 511145006884 active site 511145006885 catalytic site [active] 511145006886 metal binding site [ion binding]; metal-binding site 511145006887 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 511145006888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145006889 putative substrate translocation pore; other site 511145006890 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 511145006891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145006892 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 511145006893 FAD binding domain; Region: FAD_binding_2; pfam00890 511145006894 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 511145006895 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 511145006896 Cysteine-rich domain; Region: CCG; pfam02754 511145006897 Cysteine-rich domain; Region: CCG; pfam02754 511145006898 hypothetical protein; Provisional; Region: PRK09956 511145006899 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 511145006900 hypothetical protein; Provisional; Region: PRK09956 511145006901 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 511145006902 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 511145006903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145006904 putative substrate translocation pore; other site 511145006905 L-rhamnonate dehydratase; Provisional; Region: PRK15440 511145006906 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 511145006907 putative active site pocket [active] 511145006908 putative metal binding site [ion binding]; other site 511145006909 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 511145006910 Transcriptional regulator [Transcription]; Region: IclR; COG1414 511145006911 Bacterial transcriptional regulator; Region: IclR; pfam01614 511145006912 hypothetical protein; Provisional; Region: PRK03673 511145006913 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 511145006914 putative MPT binding site; other site 511145006915 Competence-damaged protein; Region: CinA; cl00666 511145006916 YfaZ precursor; Region: YfaZ; pfam07437 511145006917 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 511145006918 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 511145006919 catalytic core [active] 511145006920 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 511145006921 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 511145006922 inhibitor-cofactor binding pocket; inhibition site 511145006923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145006924 catalytic residue [active] 511145006925 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 511145006926 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 511145006927 Ligand binding site; other site 511145006928 Putative Catalytic site; other site 511145006929 DXD motif; other site 511145006930 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 511145006931 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 511145006932 substrate binding site [chemical binding]; other site 511145006933 cosubstrate binding site; other site 511145006934 catalytic site [active] 511145006935 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 511145006936 active site 511145006937 hexamer interface [polypeptide binding]; other site 511145006938 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 511145006939 NAD binding site [chemical binding]; other site 511145006940 substrate binding site [chemical binding]; other site 511145006941 active site 511145006942 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 511145006943 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 511145006944 putative active site [active] 511145006945 putative catalytic site [active] 511145006946 putative Zn binding site [ion binding]; other site 511145006947 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 511145006948 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 511145006949 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 511145006950 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 511145006951 signal transduction protein PmrD; Provisional; Region: PRK15450 511145006952 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 511145006953 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 511145006954 acyl-activating enzyme (AAE) consensus motif; other site 511145006955 putative AMP binding site [chemical binding]; other site 511145006956 putative active site [active] 511145006957 putative CoA binding site [chemical binding]; other site 511145006958 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 511145006959 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 511145006960 active site 511145006961 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 511145006962 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511145006963 substrate binding site [chemical binding]; other site 511145006964 oxyanion hole (OAH) forming residues; other site 511145006965 trimer interface [polypeptide binding]; other site 511145006966 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 511145006967 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 511145006968 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 511145006969 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 511145006970 dimer interface [polypeptide binding]; other site 511145006971 tetramer interface [polypeptide binding]; other site 511145006972 PYR/PP interface [polypeptide binding]; other site 511145006973 TPP binding site [chemical binding]; other site 511145006974 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 511145006975 TPP-binding site; other site 511145006976 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 511145006977 isochorismate synthases; Region: isochor_syn; TIGR00543 511145006978 hypothetical protein; Provisional; Region: PRK10404 511145006979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145006980 Coenzyme A binding pocket [chemical binding]; other site 511145006981 ribonuclease BN; Region: true_RNase_BN; TIGR02649 511145006982 deubiquitinase; Provisional; Region: PRK11836 511145006983 von Willebrand factor; Region: vWF_A; pfam12450 511145006984 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 511145006985 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 511145006986 metal ion-dependent adhesion site (MIDAS); other site 511145006987 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 511145006988 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 511145006989 M28 Zn-Peptidases; Region: M28_like_1; cd05640 511145006990 metal binding site [ion binding]; metal-binding site 511145006991 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 511145006992 Tetratricopeptide repeat; Region: TPR_14; pfam13428 511145006993 Tetratricopeptide repeat; Region: TPR_16; pfam13432 511145006994 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 511145006995 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511145006996 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 511145006997 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511145006998 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 511145006999 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 511145007000 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511145007001 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 511145007002 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 511145007003 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 511145007004 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145007005 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 511145007006 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 511145007007 NADH dehydrogenase subunit G; Validated; Region: PRK08166 511145007008 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511145007009 catalytic loop [active] 511145007010 iron binding site [ion binding]; other site 511145007011 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 511145007012 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 511145007013 [4Fe-4S] binding site [ion binding]; other site 511145007014 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 511145007015 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 511145007016 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 511145007017 SLBB domain; Region: SLBB; pfam10531 511145007018 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 511145007019 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 511145007020 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 511145007021 putative dimer interface [polypeptide binding]; other site 511145007022 [2Fe-2S] cluster binding site [ion binding]; other site 511145007023 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 511145007024 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 511145007025 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 511145007026 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 511145007027 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 511145007028 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 511145007029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145007030 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 511145007031 putative dimerization interface [polypeptide binding]; other site 511145007032 aminotransferase AlaT; Validated; Region: PRK09265 511145007033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145007034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145007035 homodimer interface [polypeptide binding]; other site 511145007036 catalytic residue [active] 511145007037 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511145007038 Zn2+ binding site [ion binding]; other site 511145007039 Mg2+ binding site [ion binding]; other site 511145007040 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 511145007041 transmembrane helices; other site 511145007042 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 511145007043 TrkA-C domain; Region: TrkA_C; pfam02080 511145007044 TrkA-C domain; Region: TrkA_C; pfam02080 511145007045 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 511145007046 putative phosphatase; Provisional; Region: PRK11587 511145007047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145007048 active site 511145007049 motif I; other site 511145007050 motif II; other site 511145007051 hypothetical protein; Validated; Region: PRK05445 511145007052 hypothetical protein; Provisional; Region: PRK01816 511145007053 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 511145007054 phosphate acetyltransferase; Reviewed; Region: PRK05632 511145007055 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511145007056 DRTGG domain; Region: DRTGG; pfam07085 511145007057 phosphate acetyltransferase; Region: pta; TIGR00651 511145007058 hypothetical protein; Provisional; Region: PRK11588 511145007059 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 511145007060 nudix motif; other site 511145007061 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 511145007062 active site 511145007063 metal binding site [ion binding]; metal-binding site 511145007064 homotetramer interface [polypeptide binding]; other site 511145007065 glutathione S-transferase; Provisional; Region: PRK15113 511145007066 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 511145007067 C-terminal domain interface [polypeptide binding]; other site 511145007068 GSH binding site (G-site) [chemical binding]; other site 511145007069 dimer interface [polypeptide binding]; other site 511145007070 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 511145007071 N-terminal domain interface [polypeptide binding]; other site 511145007072 putative dimer interface [polypeptide binding]; other site 511145007073 putative substrate binding pocket (H-site) [chemical binding]; other site 511145007074 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 511145007075 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 511145007076 C-terminal domain interface [polypeptide binding]; other site 511145007077 GSH binding site (G-site) [chemical binding]; other site 511145007078 dimer interface [polypeptide binding]; other site 511145007079 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 511145007080 N-terminal domain interface [polypeptide binding]; other site 511145007081 putative dimer interface [polypeptide binding]; other site 511145007082 active site 511145007083 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 511145007084 homooctamer interface [polypeptide binding]; other site 511145007085 active site 511145007086 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 511145007087 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 511145007088 putative NAD(P) binding site [chemical binding]; other site 511145007089 putative active site [active] 511145007090 hypothetical protein; Provisional; Region: PRK09956 511145007091 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 511145007092 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 511145007093 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511145007094 Walker A/P-loop; other site 511145007095 ATP binding site [chemical binding]; other site 511145007096 Q-loop/lid; other site 511145007097 ABC transporter signature motif; other site 511145007098 Walker B; other site 511145007099 D-loop; other site 511145007100 H-loop/switch region; other site 511145007101 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 511145007102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145007103 dimer interface [polypeptide binding]; other site 511145007104 conserved gate region; other site 511145007105 putative PBP binding loops; other site 511145007106 ABC-ATPase subunit interface; other site 511145007107 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511145007108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145007109 dimer interface [polypeptide binding]; other site 511145007110 conserved gate region; other site 511145007111 putative PBP binding loops; other site 511145007112 ABC-ATPase subunit interface; other site 511145007113 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 511145007114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145007115 substrate binding pocket [chemical binding]; other site 511145007116 membrane-bound complex binding site; other site 511145007117 hinge residues; other site 511145007118 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 511145007119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145007120 substrate binding pocket [chemical binding]; other site 511145007121 membrane-bound complex binding site; other site 511145007122 hinge residues; other site 511145007123 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 511145007124 amidophosphoribosyltransferase; Provisional; Region: PRK09246 511145007125 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 511145007126 active site 511145007127 tetramer interface [polypeptide binding]; other site 511145007128 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511145007129 active site 511145007130 colicin V production protein; Provisional; Region: PRK10845 511145007131 cell division protein DedD; Provisional; Region: PRK11633 511145007132 Sporulation related domain; Region: SPOR; pfam05036 511145007133 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 511145007134 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511145007135 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511145007136 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 511145007137 hypothetical protein; Provisional; Region: PRK10847 511145007138 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 511145007139 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 511145007140 dimerization interface 3.5A [polypeptide binding]; other site 511145007141 active site 511145007142 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 511145007143 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 511145007144 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 511145007145 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 511145007146 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 511145007147 ligand binding site [chemical binding]; other site 511145007148 NAD binding site [chemical binding]; other site 511145007149 catalytic site [active] 511145007150 homodimer interface [polypeptide binding]; other site 511145007151 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 511145007152 putative transporter; Provisional; Region: PRK12382 511145007153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145007154 putative substrate translocation pore; other site 511145007155 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 511145007156 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 511145007157 dimer interface [polypeptide binding]; other site 511145007158 active site 511145007159 Uncharacterized conserved protein [Function unknown]; Region: COG4121 511145007160 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 511145007161 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 511145007162 YfcL protein; Region: YfcL; pfam08891 511145007163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 511145007164 hypothetical protein; Provisional; Region: PRK10621 511145007165 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 511145007166 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 511145007167 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 511145007168 Tetramer interface [polypeptide binding]; other site 511145007169 active site 511145007170 FMN-binding site [chemical binding]; other site 511145007171 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 511145007172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145007173 S-adenosylmethionine binding site [chemical binding]; other site 511145007174 hypothetical protein; Provisional; Region: PRK04946 511145007175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 511145007176 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 511145007177 Fimbrial protein; Region: Fimbrial; cl01416 511145007178 Fimbrial protein; Region: Fimbrial; cl01416 511145007179 Fimbrial protein; Region: Fimbrial; cl01416 511145007180 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145007181 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145007182 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 511145007183 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511145007184 catalytic core [active] 511145007185 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 511145007186 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511145007187 substrate binding site [chemical binding]; other site 511145007188 oxyanion hole (OAH) forming residues; other site 511145007189 trimer interface [polypeptide binding]; other site 511145007190 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 511145007191 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511145007192 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511145007193 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 511145007194 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 511145007195 dimer interface [polypeptide binding]; other site 511145007196 active site 511145007197 conserved hypothetical protein; Region: TIGR00743 511145007198 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 511145007199 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 511145007200 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 511145007201 cryptic prophage CPS-53 511145007202 integrase; Provisional; Region: PRK09692 511145007203 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 511145007204 active site 511145007205 Int/Topo IB signature motif; other site 511145007206 Predicted membrane protein [Function unknown]; Region: COG2246 511145007207 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 511145007208 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 511145007209 Ligand binding site; other site 511145007210 Putative Catalytic site; other site 511145007211 DXD motif; other site 511145007212 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 511145007213 PerC transcriptional activator; Region: PerC; pfam06069 511145007214 Uncharacterized conserved protein [Function unknown]; Region: COG5532 511145007215 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 511145007216 Protein of unknown function (DUF551); Region: DUF551; pfam04448 511145007217 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 511145007218 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 511145007219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145007220 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 511145007221 dimerization interface [polypeptide binding]; other site 511145007222 substrate binding pocket [chemical binding]; other site 511145007223 permease DsdX; Provisional; Region: PRK09921 511145007224 GntP family permease; Region: GntP_permease; pfam02447 511145007225 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 511145007226 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511145007227 catalytic residue [active] 511145007228 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 511145007229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145007230 putative substrate translocation pore; other site 511145007231 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 511145007232 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145007233 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145007234 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 511145007235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145007236 active site 511145007237 phosphorylation site [posttranslational modification] 511145007238 intermolecular recognition site; other site 511145007239 dimerization interface [polypeptide binding]; other site 511145007240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145007241 DNA binding residues [nucleotide binding] 511145007242 dimerization interface [polypeptide binding]; other site 511145007243 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 511145007244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145007245 substrate binding pocket [chemical binding]; other site 511145007246 membrane-bound complex binding site; other site 511145007247 hinge residues; other site 511145007248 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145007249 substrate binding pocket [chemical binding]; other site 511145007250 membrane-bound complex binding site; other site 511145007251 hinge residues; other site 511145007252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145007253 dimer interface [polypeptide binding]; other site 511145007254 phosphorylation site [posttranslational modification] 511145007255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145007256 ATP binding site [chemical binding]; other site 511145007257 Mg2+ binding site [ion binding]; other site 511145007258 G-X-G motif; other site 511145007259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145007260 active site 511145007261 phosphorylation site [posttranslational modification] 511145007262 intermolecular recognition site; other site 511145007263 dimerization interface [polypeptide binding]; other site 511145007264 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 511145007265 putative binding surface; other site 511145007266 active site 511145007267 putative CoA-transferase; Provisional; Region: PRK11430 511145007268 putative transporter YfdV; Provisional; Region: PRK09903 511145007269 oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254 511145007270 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 511145007271 PYR/PP interface [polypeptide binding]; other site 511145007272 dimer interface [polypeptide binding]; other site 511145007273 TPP binding site [chemical binding]; other site 511145007274 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511145007275 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 511145007276 TPP-binding site; other site 511145007277 dimer interface [polypeptide binding]; other site 511145007278 formyl-coenzyme A transferase; Provisional; Region: PRK05398 511145007279 hypothetical protein; Provisional; Region: PRK10316 511145007280 YfdX protein; Region: YfdX; pfam10938 511145007281 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 511145007282 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 511145007283 putative acyl-acceptor binding pocket; other site 511145007284 aminotransferase; Validated; Region: PRK08175 511145007285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145007286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145007287 homodimer interface [polypeptide binding]; other site 511145007288 catalytic residue [active] 511145007289 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 511145007290 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 511145007291 GAF domain; Region: GAF; pfam01590 511145007292 Histidine kinase; Region: His_kinase; pfam06580 511145007293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145007294 ATP binding site [chemical binding]; other site 511145007295 Mg2+ binding site [ion binding]; other site 511145007296 G-X-G motif; other site 511145007297 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 511145007298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145007299 active site 511145007300 phosphorylation site [posttranslational modification] 511145007301 intermolecular recognition site; other site 511145007302 dimerization interface [polypeptide binding]; other site 511145007303 LytTr DNA-binding domain; Region: LytTR; pfam04397 511145007304 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511145007305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145007306 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511145007307 dimerization domain swap beta strand [polypeptide binding]; other site 511145007308 regulatory protein interface [polypeptide binding]; other site 511145007309 active site 511145007310 regulatory phosphorylation site [posttranslational modification]; other site 511145007311 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 511145007312 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 511145007313 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511145007314 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511145007315 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145007316 active site 511145007317 phosphorylation site [posttranslational modification] 511145007318 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 511145007319 oligomer interface [polypeptide binding]; other site 511145007320 active site 511145007321 metal binding site [ion binding]; metal-binding site 511145007322 aminopeptidase; Provisional; Region: PRK09795 511145007323 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 511145007324 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 511145007325 active site 511145007326 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 511145007327 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 511145007328 active site 511145007329 P-loop; other site 511145007330 phosphorylation site [posttranslational modification] 511145007331 glucokinase; Provisional; Region: glk; PRK00292 511145007332 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145007333 nucleotide binding site [chemical binding]; other site 511145007334 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 511145007335 Cl- selectivity filter; other site 511145007336 Cl- binding residues [ion binding]; other site 511145007337 pore gating glutamate residue; other site 511145007338 dimer interface [polypeptide binding]; other site 511145007339 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 511145007340 manganese transport protein MntH; Reviewed; Region: PRK00701 511145007341 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511145007342 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 511145007343 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 511145007344 Nucleoside recognition; Region: Gate; pfam07670 511145007345 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 511145007346 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 511145007347 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511145007348 MASE1; Region: MASE1; pfam05231 511145007349 diguanylate cyclase; Region: GGDEF; smart00267 511145007350 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145007351 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 511145007352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145007353 salt bridge; other site 511145007354 non-specific DNA binding site [nucleotide binding]; other site 511145007355 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 511145007356 sequence-specific DNA binding site [nucleotide binding]; other site 511145007357 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511145007358 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511145007359 active site 511145007360 HIGH motif; other site 511145007361 KMSKS motif; other site 511145007362 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 511145007363 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 511145007364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145007365 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 511145007366 putative dimerization interface [polypeptide binding]; other site 511145007367 putative substrate binding pocket [chemical binding]; other site 511145007368 nucleoside transporter; Region: 2A0110; TIGR00889 511145007369 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 511145007370 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 511145007371 purine nucleoside phosphorylase; Provisional; Region: PRK08202 511145007372 hypothetical protein; Provisional; Region: PRK11528 511145007373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145007374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145007375 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 511145007376 putative dimerization interface [polypeptide binding]; other site 511145007377 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 511145007378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 511145007379 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 511145007380 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 511145007381 nucleotide binding pocket [chemical binding]; other site 511145007382 K-X-D-G motif; other site 511145007383 catalytic site [active] 511145007384 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 511145007385 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 511145007386 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 511145007387 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 511145007388 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 511145007389 Dimer interface [polypeptide binding]; other site 511145007390 BRCT sequence motif; other site 511145007391 cell division protein ZipA; Provisional; Region: PRK03427 511145007392 hypothetical protein; Provisional; Region: PHA03160 511145007393 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 511145007394 FtsZ protein binding site [polypeptide binding]; other site 511145007395 putative sulfate transport protein CysZ; Validated; Region: PRK04949 511145007396 cysteine synthase; Region: PLN02565 511145007397 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 511145007398 dimer interface [polypeptide binding]; other site 511145007399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145007400 catalytic residue [active] 511145007401 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511145007402 dimerization domain swap beta strand [polypeptide binding]; other site 511145007403 regulatory protein interface [polypeptide binding]; other site 511145007404 active site 511145007405 regulatory phosphorylation site [posttranslational modification]; other site 511145007406 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 511145007407 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 511145007408 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511145007409 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511145007410 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 511145007411 HPr interaction site; other site 511145007412 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511145007413 active site 511145007414 phosphorylation site [posttranslational modification] 511145007415 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 511145007416 dimer interface [polypeptide binding]; other site 511145007417 pyridoxal binding site [chemical binding]; other site 511145007418 ATP binding site [chemical binding]; other site 511145007419 hypothetical protein; Provisional; Region: PRK10318 511145007420 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 511145007421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 511145007422 cysteine synthase; Region: PLN02565 511145007423 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 511145007424 dimer interface [polypeptide binding]; other site 511145007425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145007426 catalytic residue [active] 511145007427 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 511145007428 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 511145007429 Walker A/P-loop; other site 511145007430 ATP binding site [chemical binding]; other site 511145007431 Q-loop/lid; other site 511145007432 ABC transporter signature motif; other site 511145007433 Walker B; other site 511145007434 D-loop; other site 511145007435 H-loop/switch region; other site 511145007436 TOBE-like domain; Region: TOBE_3; pfam12857 511145007437 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 511145007438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145007439 dimer interface [polypeptide binding]; other site 511145007440 conserved gate region; other site 511145007441 putative PBP binding loops; other site 511145007442 ABC-ATPase subunit interface; other site 511145007443 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 511145007444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145007445 dimer interface [polypeptide binding]; other site 511145007446 conserved gate region; other site 511145007447 putative PBP binding loops; other site 511145007448 ABC-ATPase subunit interface; other site 511145007449 thiosulfate transporter subunit; Provisional; Region: PRK10852 511145007450 short chain dehydrogenase; Provisional; Region: PRK08226 511145007451 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 511145007452 NAD binding site [chemical binding]; other site 511145007453 homotetramer interface [polypeptide binding]; other site 511145007454 homodimer interface [polypeptide binding]; other site 511145007455 active site 511145007456 transcriptional regulator MurR; Provisional; Region: PRK15482 511145007457 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 511145007458 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 511145007459 putative active site [active] 511145007460 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 511145007461 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 511145007462 putative active site [active] 511145007463 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 511145007464 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511145007465 active site turn [active] 511145007466 phosphorylation site [posttranslational modification] 511145007467 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511145007468 putative periplasmic esterase; Provisional; Region: PRK03642 511145007469 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 511145007470 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 511145007471 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 511145007472 putative acetyltransferase; Provisional; Region: PRK03624 511145007473 Uncharacterized conserved protein [Function unknown]; Region: COG3375 511145007474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145007475 Coenzyme A binding pocket [chemical binding]; other site 511145007476 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 511145007477 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511145007478 active site 511145007479 metal binding site [ion binding]; metal-binding site 511145007480 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 511145007481 transcriptional regulator EutR; Provisional; Region: PRK10130 511145007482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145007483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145007484 carboxysome structural protein EutK; Provisional; Region: PRK15466 511145007485 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 511145007486 Hexamer interface [polypeptide binding]; other site 511145007487 Hexagonal pore residue; other site 511145007488 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 511145007489 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 511145007490 putative hexamer interface [polypeptide binding]; other site 511145007491 putative hexagonal pore; other site 511145007492 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 511145007493 putative hexamer interface [polypeptide binding]; other site 511145007494 putative hexagonal pore; other site 511145007495 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 511145007496 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 511145007497 cryptic prophage Eut/CPZ-55 511145007498 integrase; Provisional; Region: PRK09692 511145007499 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 511145007500 active site 511145007501 Int/Topo IB signature motif; other site 511145007502 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 511145007503 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 511145007504 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 511145007505 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 511145007506 active site 511145007507 metal binding site [ion binding]; metal-binding site 511145007508 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 511145007509 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145007510 nucleotide binding site [chemical binding]; other site 511145007511 nucleotide binding site [chemical binding]; other site 511145007512 Cell division protein FtsA; Region: FtsA; cl17206 511145007513 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 511145007514 putative catalytic cysteine [active] 511145007515 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 511145007516 Hexamer/Pentamer interface [polypeptide binding]; other site 511145007517 central pore; other site 511145007518 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 511145007519 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 511145007520 Hexamer interface [polypeptide binding]; other site 511145007521 Hexagonal pore residue; other site 511145007522 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 511145007523 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 511145007524 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 511145007525 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 511145007526 G1 box; other site 511145007527 GTP/Mg2+ binding site [chemical binding]; other site 511145007528 G2 box; other site 511145007529 Switch I region; other site 511145007530 G3 box; other site 511145007531 Switch II region; other site 511145007532 G4 box; other site 511145007533 G5 box; other site 511145007534 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 511145007535 putative hexamer interface [polypeptide binding]; other site 511145007536 putative hexagonal pore; other site 511145007537 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 511145007538 Malic enzyme, N-terminal domain; Region: malic; pfam00390 511145007539 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 511145007540 putative NAD(P) binding site [chemical binding]; other site 511145007541 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 511145007542 transaldolase-like protein; Provisional; Region: PTZ00411 511145007543 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 511145007544 active site 511145007545 dimer interface [polypeptide binding]; other site 511145007546 catalytic residue [active] 511145007547 transketolase; Reviewed; Region: PRK12753 511145007548 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 511145007549 TPP-binding site [chemical binding]; other site 511145007550 dimer interface [polypeptide binding]; other site 511145007551 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 511145007552 PYR/PP interface [polypeptide binding]; other site 511145007553 dimer interface [polypeptide binding]; other site 511145007554 TPP binding site [chemical binding]; other site 511145007555 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511145007556 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 511145007557 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 511145007558 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511145007559 dimer interface [polypeptide binding]; other site 511145007560 ADP-ribose binding site [chemical binding]; other site 511145007561 active site 511145007562 nudix motif; other site 511145007563 metal binding site [ion binding]; metal-binding site 511145007564 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 511145007565 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145007566 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 511145007567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145007568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145007569 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 511145007570 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 511145007571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145007572 dimerization interface [polypeptide binding]; other site 511145007573 Histidine kinase; Region: HisKA_3; pfam07730 511145007574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145007575 ATP binding site [chemical binding]; other site 511145007576 Mg2+ binding site [ion binding]; other site 511145007577 G-X-G motif; other site 511145007578 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 511145007579 MMPL family; Region: MMPL; cl14618 511145007580 MMPL family; Region: MMPL; cl14618 511145007581 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 511145007582 putative catalytic residues [active] 511145007583 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 511145007584 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 511145007585 metal binding site [ion binding]; metal-binding site 511145007586 dimer interface [polypeptide binding]; other site 511145007587 hypothetical protein; Provisional; Region: PRK13664 511145007588 putative hydrolase; Provisional; Region: PRK11460 511145007589 Predicted esterase [General function prediction only]; Region: COG0400 511145007590 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 511145007591 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 511145007592 Helicase; Region: Helicase_RecD; pfam05127 511145007593 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 511145007594 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 511145007595 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 511145007596 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 511145007597 ATP binding site [chemical binding]; other site 511145007598 active site 511145007599 substrate binding site [chemical binding]; other site 511145007600 lipoprotein; Provisional; Region: PRK11679 511145007601 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 511145007602 dimer interface [polypeptide binding]; other site 511145007603 active site 511145007604 catalytic residue [active] 511145007605 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 511145007606 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 511145007607 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511145007608 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 511145007609 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 511145007610 catalytic triad [active] 511145007611 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 511145007612 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145007613 hydrogenase 4 subunit B; Validated; Region: PRK06521 511145007614 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511145007615 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 511145007616 hydrogenase 4 subunit D; Validated; Region: PRK06525 511145007617 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511145007618 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 511145007619 hydrogenase 4 subunit F; Validated; Region: PRK06458 511145007620 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511145007621 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 511145007622 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 511145007623 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 511145007624 hydrogenase 4 subunit H; Validated; Region: PRK08222 511145007625 4Fe-4S binding domain; Region: Fer4; pfam00037 511145007626 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 511145007627 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 511145007628 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 511145007629 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 511145007630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145007631 Walker A motif; other site 511145007632 ATP binding site [chemical binding]; other site 511145007633 Walker B motif; other site 511145007634 arginine finger; other site 511145007635 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511145007636 putative formate transporter; Provisional; Region: focB; PRK09713 511145007637 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 511145007638 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 511145007639 Peptidase family M48; Region: Peptidase_M48; cl12018 511145007640 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 511145007641 catalytic residues [active] 511145007642 DNA replication initiation factor; Provisional; Region: PRK08084 511145007643 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 511145007644 uracil transporter; Provisional; Region: PRK10720 511145007645 uracil-xanthine permease; Region: ncs2; TIGR00801 511145007646 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511145007647 active site 511145007648 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 511145007649 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 511145007650 dimerization interface [polypeptide binding]; other site 511145007651 putative ATP binding site [chemical binding]; other site 511145007652 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 511145007653 active site 511145007654 substrate binding site [chemical binding]; other site 511145007655 cosubstrate binding site; other site 511145007656 catalytic site [active] 511145007657 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 511145007658 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 511145007659 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 511145007660 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 511145007661 domain interface [polypeptide binding]; other site 511145007662 active site 511145007663 catalytic site [active] 511145007664 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 511145007665 domain interface [polypeptide binding]; other site 511145007666 active site 511145007667 catalytic site [active] 511145007668 exopolyphosphatase; Provisional; Region: PRK10854 511145007669 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 511145007670 MASE1; Region: MASE1; pfam05231 511145007671 diguanylate cyclase; Region: GGDEF; smart00267 511145007672 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145007673 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 511145007674 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 511145007675 GMP synthase; Reviewed; Region: guaA; PRK00074 511145007676 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 511145007677 AMP/PPi binding site [chemical binding]; other site 511145007678 candidate oxyanion hole; other site 511145007679 catalytic triad [active] 511145007680 potential glutamine specificity residues [chemical binding]; other site 511145007681 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 511145007682 ATP Binding subdomain [chemical binding]; other site 511145007683 Ligand Binding sites [chemical binding]; other site 511145007684 Dimerization subdomain; other site 511145007685 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 511145007686 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 511145007687 active site 511145007688 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 511145007689 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 511145007690 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 511145007691 generic binding surface II; other site 511145007692 generic binding surface I; other site 511145007693 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 511145007694 GTP-binding protein Der; Reviewed; Region: PRK00093 511145007695 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 511145007696 G1 box; other site 511145007697 GTP/Mg2+ binding site [chemical binding]; other site 511145007698 Switch I region; other site 511145007699 G2 box; other site 511145007700 Switch II region; other site 511145007701 G3 box; other site 511145007702 G4 box; other site 511145007703 G5 box; other site 511145007704 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 511145007705 G1 box; other site 511145007706 GTP/Mg2+ binding site [chemical binding]; other site 511145007707 Switch I region; other site 511145007708 G2 box; other site 511145007709 G3 box; other site 511145007710 Switch II region; other site 511145007711 G4 box; other site 511145007712 G5 box; other site 511145007713 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 511145007714 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 511145007715 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 511145007716 Trp docking motif [polypeptide binding]; other site 511145007717 active site 511145007718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 511145007719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 511145007720 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 511145007721 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 511145007722 dimer interface [polypeptide binding]; other site 511145007723 motif 1; other site 511145007724 active site 511145007725 motif 2; other site 511145007726 motif 3; other site 511145007727 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 511145007728 anticodon binding site; other site 511145007729 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 511145007730 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 511145007731 cytoskeletal protein RodZ; Provisional; Region: PRK10856 511145007732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145007733 non-specific DNA binding site [nucleotide binding]; other site 511145007734 salt bridge; other site 511145007735 sequence-specific DNA binding site [nucleotide binding]; other site 511145007736 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 511145007737 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 511145007738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145007739 FeS/SAM binding site; other site 511145007740 Nucleoside diphosphate kinase; Region: NDK; pfam00334 511145007741 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 511145007742 active site 511145007743 multimer interface [polypeptide binding]; other site 511145007744 penicillin-binding protein 1C; Provisional; Region: PRK11240 511145007745 Transglycosylase; Region: Transgly; pfam00912 511145007746 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 511145007747 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 511145007748 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 511145007749 MG2 domain; Region: A2M_N; pfam01835 511145007750 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 511145007751 Alpha-2-macroglobulin family; Region: A2M; pfam00207 511145007752 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 511145007753 surface patch; other site 511145007754 thioester region; other site 511145007755 specificity defining residues; other site 511145007756 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 511145007757 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 511145007758 active site residue [active] 511145007759 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 511145007760 active site residue [active] 511145007761 SseB protein N-terminal domain; Region: SseB; pfam07179 511145007762 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 511145007763 SseB protein C-terminal domain; Region: SseB_C; pfam14581 511145007764 aminopeptidase B; Provisional; Region: PRK05015 511145007765 Peptidase; Region: DUF3663; pfam12404 511145007766 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 511145007767 interface (dimer of trimers) [polypeptide binding]; other site 511145007768 Substrate-binding/catalytic site; other site 511145007769 Zn-binding sites [ion binding]; other site 511145007770 hypothetical protein; Provisional; Region: PRK10721 511145007771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511145007772 catalytic loop [active] 511145007773 iron binding site [ion binding]; other site 511145007774 chaperone protein HscA; Provisional; Region: hscA; PRK05183 511145007775 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 511145007776 nucleotide binding site [chemical binding]; other site 511145007777 putative NEF/HSP70 interaction site [polypeptide binding]; other site 511145007778 SBD interface [polypeptide binding]; other site 511145007779 co-chaperone HscB; Provisional; Region: hscB; PRK05014 511145007780 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511145007781 HSP70 interaction site [polypeptide binding]; other site 511145007782 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 511145007783 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 511145007784 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 511145007785 trimerization site [polypeptide binding]; other site 511145007786 active site 511145007787 cysteine desulfurase; Provisional; Region: PRK14012 511145007788 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511145007789 catalytic residue [active] 511145007790 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 511145007791 Rrf2 family protein; Region: rrf2_super; TIGR00738 511145007792 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 511145007793 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 511145007794 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 511145007795 active site 511145007796 dimerization interface [polypeptide binding]; other site 511145007797 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 511145007798 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 511145007799 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 511145007800 PRD domain; Region: PRD; pfam00874 511145007801 PRD domain; Region: PRD; pfam00874 511145007802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145007803 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 511145007804 putative substrate translocation pore; other site 511145007805 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 511145007806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145007807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145007808 dimerization interface [polypeptide binding]; other site 511145007809 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 511145007810 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 511145007811 iron-sulfur cluster [ion binding]; other site 511145007812 [2Fe-2S] cluster binding site [ion binding]; other site 511145007813 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 511145007814 beta subunit interface [polypeptide binding]; other site 511145007815 alpha subunit interface [polypeptide binding]; other site 511145007816 active site 511145007817 substrate binding site [chemical binding]; other site 511145007818 Fe binding site [ion binding]; other site 511145007819 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 511145007820 inter-subunit interface; other site 511145007821 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 511145007822 [2Fe-2S] cluster binding site [ion binding]; other site 511145007823 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 511145007824 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 511145007825 NAD binding site [chemical binding]; other site 511145007826 active site 511145007827 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 511145007828 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 511145007829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145007830 Reductase C-terminal; Region: Reductase_C; pfam14759 511145007831 Predicted membrane protein [Function unknown]; Region: COG2259 511145007832 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 511145007833 active site 511145007834 catalytic residues [active] 511145007835 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511145007836 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 511145007837 putative NAD(P) binding site [chemical binding]; other site 511145007838 catalytic Zn binding site [ion binding]; other site 511145007839 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145007840 TM-ABC transporter signature motif; other site 511145007841 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 511145007842 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511145007843 Walker A/P-loop; other site 511145007844 ATP binding site [chemical binding]; other site 511145007845 Q-loop/lid; other site 511145007846 ABC transporter signature motif; other site 511145007847 Walker B; other site 511145007848 D-loop; other site 511145007849 H-loop/switch region; other site 511145007850 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511145007851 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 511145007852 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 511145007853 ligand binding site [chemical binding]; other site 511145007854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145007855 TPR motif; other site 511145007856 Tetratricopeptide repeat; Region: TPR_16; pfam13432 511145007857 binding surface 511145007858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145007859 binding surface 511145007860 Tetratricopeptide repeat; Region: TPR_16; pfam13432 511145007861 TPR motif; other site 511145007862 TPR repeat; Region: TPR_11; pfam13414 511145007863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145007864 TPR motif; other site 511145007865 binding surface 511145007866 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 511145007867 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511145007868 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145007869 nucleotide binding site [chemical binding]; other site 511145007870 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 511145007871 dimer interface [polypeptide binding]; other site 511145007872 active site 511145007873 glycine-pyridoxal phosphate binding site [chemical binding]; other site 511145007874 folate binding site [chemical binding]; other site 511145007875 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 511145007876 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 511145007877 heme-binding site [chemical binding]; other site 511145007878 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 511145007879 FAD binding pocket [chemical binding]; other site 511145007880 FAD binding motif [chemical binding]; other site 511145007881 phosphate binding motif [ion binding]; other site 511145007882 beta-alpha-beta structure motif; other site 511145007883 NAD binding pocket [chemical binding]; other site 511145007884 Heme binding pocket [chemical binding]; other site 511145007885 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 511145007886 response regulator GlrR; Provisional; Region: PRK15115 511145007887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145007888 active site 511145007889 phosphorylation site [posttranslational modification] 511145007890 intermolecular recognition site; other site 511145007891 dimerization interface [polypeptide binding]; other site 511145007892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145007893 Walker A motif; other site 511145007894 ATP binding site [chemical binding]; other site 511145007895 Walker B motif; other site 511145007896 arginine finger; other site 511145007897 hypothetical protein; Provisional; Region: PRK10722 511145007898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511145007899 HAMP domain; Region: HAMP; pfam00672 511145007900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145007901 dimer interface [polypeptide binding]; other site 511145007902 phosphorylation site [posttranslational modification] 511145007903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145007904 ATP binding site [chemical binding]; other site 511145007905 Mg2+ binding site [ion binding]; other site 511145007906 G-X-G motif; other site 511145007907 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 511145007908 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 511145007909 dimerization interface [polypeptide binding]; other site 511145007910 ATP binding site [chemical binding]; other site 511145007911 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 511145007912 dimerization interface [polypeptide binding]; other site 511145007913 ATP binding site [chemical binding]; other site 511145007914 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 511145007915 putative active site [active] 511145007916 catalytic triad [active] 511145007917 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 511145007918 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145007919 substrate binding pocket [chemical binding]; other site 511145007920 membrane-bound complex binding site; other site 511145007921 hinge residues; other site 511145007922 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 511145007923 N-acetyl-D-glucosamine binding site [chemical binding]; other site 511145007924 catalytic residue [active] 511145007925 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 511145007926 nucleoside/Zn binding site; other site 511145007927 dimer interface [polypeptide binding]; other site 511145007928 catalytic motif [active] 511145007929 hypothetical protein; Provisional; Region: PRK11590 511145007930 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 511145007931 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 511145007932 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 511145007933 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 511145007934 putative active site [active] 511145007935 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 511145007936 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 511145007937 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 511145007938 active site 511145007939 hydrophilic channel; other site 511145007940 dimerization interface [polypeptide binding]; other site 511145007941 catalytic residues [active] 511145007942 active site lid [active] 511145007943 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 511145007944 Recombination protein O N terminal; Region: RecO_N; pfam11967 511145007945 Recombination protein O C terminal; Region: RecO_C; pfam02565 511145007946 GTPase Era; Reviewed; Region: era; PRK00089 511145007947 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 511145007948 G1 box; other site 511145007949 GTP/Mg2+ binding site [chemical binding]; other site 511145007950 Switch I region; other site 511145007951 G2 box; other site 511145007952 Switch II region; other site 511145007953 G3 box; other site 511145007954 G4 box; other site 511145007955 G5 box; other site 511145007956 KH domain; Region: KH_2; pfam07650 511145007957 ribonuclease III; Reviewed; Region: rnc; PRK00102 511145007958 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 511145007959 dimerization interface [polypeptide binding]; other site 511145007960 active site 511145007961 metal binding site [ion binding]; metal-binding site 511145007962 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 511145007963 dsRNA binding site [nucleotide binding]; other site 511145007964 signal peptidase I; Provisional; Region: PRK10861 511145007965 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511145007966 Catalytic site [active] 511145007967 GTP-binding protein LepA; Provisional; Region: PRK05433 511145007968 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 511145007969 G1 box; other site 511145007970 putative GEF interaction site [polypeptide binding]; other site 511145007971 GTP/Mg2+ binding site [chemical binding]; other site 511145007972 Switch I region; other site 511145007973 G2 box; other site 511145007974 G3 box; other site 511145007975 Switch II region; other site 511145007976 G4 box; other site 511145007977 G5 box; other site 511145007978 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 511145007979 Elongation Factor G, domain II; Region: EFG_II; pfam14492 511145007980 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 511145007981 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 511145007982 SoxR reducing system protein RseC; Provisional; Region: PRK10862 511145007983 anti-sigma E factor; Provisional; Region: rseB; PRK09455 511145007984 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 511145007985 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 511145007986 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 511145007987 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 511145007988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511145007989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511145007990 DNA binding residues [nucleotide binding] 511145007991 L-aspartate oxidase; Provisional; Region: PRK09077 511145007992 L-aspartate oxidase; Provisional; Region: PRK06175 511145007993 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 511145007994 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 511145007995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145007996 S-adenosylmethionine binding site [chemical binding]; other site 511145007997 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 511145007998 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511145007999 ATP binding site [chemical binding]; other site 511145008000 Mg++ binding site [ion binding]; other site 511145008001 motif III; other site 511145008002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145008003 nucleotide binding region [chemical binding]; other site 511145008004 ATP-binding site [chemical binding]; other site 511145008005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145008006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145008007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511145008008 dimerization interface [polypeptide binding]; other site 511145008009 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 511145008010 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 511145008011 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 511145008012 ligand binding site [chemical binding]; other site 511145008013 active site 511145008014 UGI interface [polypeptide binding]; other site 511145008015 catalytic site [active] 511145008016 putative methyltransferase; Provisional; Region: PRK10864 511145008017 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 511145008018 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511145008019 thioredoxin 2; Provisional; Region: PRK10996 511145008020 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 511145008021 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511145008022 catalytic residues [active] 511145008023 Uncharacterized conserved protein [Function unknown]; Region: COG3148 511145008024 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 511145008025 CoA binding domain; Region: CoA_binding_2; pfam13380 511145008026 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 511145008027 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 511145008028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 511145008029 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 511145008030 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 511145008031 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 511145008032 domain interface [polypeptide binding]; other site 511145008033 putative active site [active] 511145008034 catalytic site [active] 511145008035 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 511145008036 domain interface [polypeptide binding]; other site 511145008037 putative active site [active] 511145008038 catalytic site [active] 511145008039 lipoprotein; Provisional; Region: PRK10759 511145008040 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 511145008041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145008042 putative substrate translocation pore; other site 511145008043 protein disaggregation chaperone; Provisional; Region: PRK10865 511145008044 Clp amino terminal domain; Region: Clp_N; pfam02861 511145008045 Clp amino terminal domain; Region: Clp_N; pfam02861 511145008046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145008047 Walker A motif; other site 511145008048 ATP binding site [chemical binding]; other site 511145008049 Walker B motif; other site 511145008050 arginine finger; other site 511145008051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145008052 Walker A motif; other site 511145008053 ATP binding site [chemical binding]; other site 511145008054 Walker B motif; other site 511145008055 arginine finger; other site 511145008056 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511145008057 hypothetical protein; Provisional; Region: PRK10723 511145008058 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 511145008059 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511145008060 RNA binding surface [nucleotide binding]; other site 511145008061 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511145008062 active site 511145008063 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 511145008064 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 511145008065 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 511145008066 30S subunit binding site; other site 511145008067 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 511145008068 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 511145008069 Prephenate dehydratase; Region: PDT; pfam00800 511145008070 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 511145008071 putative L-Phe binding site [chemical binding]; other site 511145008072 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 511145008073 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 511145008074 prephenate dehydrogenase; Validated; Region: PRK08507 511145008075 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 511145008076 lipoprotein; Provisional; Region: PRK11443 511145008077 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 511145008078 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 511145008079 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145008080 metal binding site [ion binding]; metal-binding site 511145008081 active site 511145008082 I-site; other site 511145008083 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 511145008084 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 511145008085 ligand binding site [chemical binding]; other site 511145008086 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 511145008087 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 511145008088 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 511145008089 RimM N-terminal domain; Region: RimM; pfam01782 511145008090 PRC-barrel domain; Region: PRC; pfam05239 511145008091 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 511145008092 signal recognition particle protein; Provisional; Region: PRK10867 511145008093 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 511145008094 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511145008095 P loop; other site 511145008096 GTP binding site [chemical binding]; other site 511145008097 Signal peptide binding domain; Region: SRP_SPB; pfam02978 511145008098 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 511145008099 hypothetical protein; Provisional; Region: PRK11573 511145008100 Domain of unknown function DUF21; Region: DUF21; pfam01595 511145008101 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511145008102 Transporter associated domain; Region: CorC_HlyC; smart01091 511145008103 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 511145008104 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 511145008105 dimer interface [polypeptide binding]; other site 511145008106 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 511145008107 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 511145008108 recombination and repair protein; Provisional; Region: PRK10869 511145008109 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 511145008110 Walker A/P-loop; other site 511145008111 ATP binding site [chemical binding]; other site 511145008112 Q-loop/lid; other site 511145008113 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 511145008114 Q-loop/lid; other site 511145008115 ABC transporter signature motif; other site 511145008116 Walker B; other site 511145008117 D-loop; other site 511145008118 H-loop/switch region; other site 511145008119 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 511145008120 hypothetical protein; Validated; Region: PRK01777 511145008121 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 511145008122 putative coenzyme Q binding site [chemical binding]; other site 511145008123 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 511145008124 SmpB-tmRNA interface; other site 511145008125 cryptic prophage CP4-57 511145008126 integrase; Provisional; Region: PRK09692 511145008127 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 511145008128 active site 511145008129 Int/Topo IB signature motif; other site 511145008130 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 511145008131 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 511145008132 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 511145008133 Superfamily II helicase [General function prediction only]; Region: COG1204 511145008134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145008135 ATP binding site [chemical binding]; other site 511145008136 putative Mg++ binding site [ion binding]; other site 511145008137 helicase superfamily c-terminal domain; Region: HELICc; smart00490 511145008138 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 511145008139 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 511145008140 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 511145008141 Predicted GTPase [General function prediction only]; Region: COG3596 511145008142 YfjP GTPase; Region: YfjP; cd11383 511145008143 G1 box; other site 511145008144 GTP/Mg2+ binding site [chemical binding]; other site 511145008145 Switch I region; other site 511145008146 G2 box; other site 511145008147 Switch II region; other site 511145008148 G3 box; other site 511145008149 G4 box; other site 511145008150 G5 box; other site 511145008151 Domain of unknown function (DUF932); Region: DUF932; pfam06067 511145008152 Predicted transcriptional regulator [Transcription]; Region: COG2378 511145008153 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 511145008154 WYL domain; Region: WYL; pfam13280 511145008155 Predicted transcriptional regulator [Transcription]; Region: COG2378 511145008156 Antirestriction protein; Region: Antirestrict; pfam03230 511145008157 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 511145008158 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 511145008159 MPN+ (JAMM) motif; other site 511145008160 Zinc-binding site [ion binding]; other site 511145008161 Protein of unknown function (DUF987); Region: DUF987; pfam06174 511145008162 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 511145008163 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 511145008164 hypothetical protein; Provisional; Region: PRK09945 511145008165 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 511145008166 hypothetical protein; Provisional; Region: PRK09945 511145008167 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 511145008168 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 511145008169 Autotransporter beta-domain; Region: Autotransporter; pfam03797 511145008170 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 511145008171 substrate binding pocket [chemical binding]; other site 511145008172 active site 511145008173 iron coordination sites [ion binding]; other site 511145008174 hydroxyglutarate oxidase; Provisional; Region: PRK11728 511145008175 Predicted dehydrogenase [General function prediction only]; Region: COG0579 511145008176 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 511145008177 tetramerization interface [polypeptide binding]; other site 511145008178 NAD(P) binding site [chemical binding]; other site 511145008179 catalytic residues [active] 511145008180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511145008181 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 511145008182 inhibitor-cofactor binding pocket; inhibition site 511145008183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145008184 catalytic residue [active] 511145008185 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 511145008186 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145008187 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 511145008188 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 511145008189 DNA-binding site [nucleotide binding]; DNA binding site 511145008190 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 511145008191 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 511145008192 bacterial OsmY and nodulation domain; Region: BON; smart00749 511145008193 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511145008194 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 511145008195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511145008196 dimerization interface [polypeptide binding]; other site 511145008197 putative DNA binding site [nucleotide binding]; other site 511145008198 Transcriptional regulators [Transcription]; Region: MarR; COG1846 511145008199 putative Zn2+ binding site [ion binding]; other site 511145008200 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 511145008201 active site residue [active] 511145008202 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 511145008203 Domain in histone-like proteins of HNS family; Region: HNS; cl19571 511145008204 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 511145008205 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 511145008206 hypothetical protein; Provisional; Region: PRK10556 511145008207 hypothetical protein; Provisional; Region: PRK10132 511145008208 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 511145008209 catalytic residues [active] 511145008210 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 511145008211 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 511145008212 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 511145008213 Class I ribonucleotide reductase; Region: RNR_I; cd01679 511145008214 active site 511145008215 dimer interface [polypeptide binding]; other site 511145008216 catalytic residues [active] 511145008217 effector binding site; other site 511145008218 R2 peptide binding site; other site 511145008219 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 511145008220 dimer interface [polypeptide binding]; other site 511145008221 putative radical transfer pathway; other site 511145008222 diiron center [ion binding]; other site 511145008223 tyrosyl radical; other site 511145008224 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 511145008225 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 511145008226 Walker A/P-loop; other site 511145008227 ATP binding site [chemical binding]; other site 511145008228 Q-loop/lid; other site 511145008229 ABC transporter signature motif; other site 511145008230 Walker B; other site 511145008231 D-loop; other site 511145008232 H-loop/switch region; other site 511145008233 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 511145008234 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 511145008235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145008236 dimer interface [polypeptide binding]; other site 511145008237 conserved gate region; other site 511145008238 putative PBP binding loops; other site 511145008239 ABC-ATPase subunit interface; other site 511145008240 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 511145008241 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 511145008242 putative L-valine exporter; Provisional; Region: PRK10408 511145008243 transcriptional repressor MprA; Provisional; Region: PRK10870 511145008244 Transcriptional regulators [Transcription]; Region: MarR; COG1846 511145008245 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 511145008246 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145008247 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145008248 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 511145008249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145008250 putative substrate translocation pore; other site 511145008251 S-ribosylhomocysteinase; Provisional; Region: PRK02260 511145008252 glutamate--cysteine ligase; Provisional; Region: PRK02107 511145008253 Predicted membrane protein [Function unknown]; Region: COG1238 511145008254 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 511145008255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145008256 active site 511145008257 motif I; other site 511145008258 motif II; other site 511145008259 carbon storage regulator; Provisional; Region: PRK01712 511145008260 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 511145008261 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 511145008262 motif 1; other site 511145008263 active site 511145008264 motif 2; other site 511145008265 motif 3; other site 511145008266 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 511145008267 DHHA1 domain; Region: DHHA1; pfam02272 511145008268 recombination regulator RecX; Reviewed; Region: recX; PRK00117 511145008269 recombinase A; Provisional; Region: recA; PRK09354 511145008270 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 511145008271 hexamer interface [polypeptide binding]; other site 511145008272 Walker A motif; other site 511145008273 ATP binding site [chemical binding]; other site 511145008274 Walker B motif; other site 511145008275 hypothetical protein; Validated; Region: PRK03661 511145008276 murein hydrolase B; Provisional; Region: PRK10760 511145008277 lytic murein transglycosylase B; Region: MltB; TIGR02282 511145008278 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 511145008279 N-acetyl-D-glucosamine binding site [chemical binding]; other site 511145008280 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 511145008281 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 511145008282 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 511145008283 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 511145008284 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 511145008285 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 511145008286 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 511145008287 putative NAD(P) binding site [chemical binding]; other site 511145008288 active site 511145008289 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 511145008290 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 511145008291 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 511145008292 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145008293 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 511145008294 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 511145008295 putative active site [active] 511145008296 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 511145008297 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 511145008298 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 511145008299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145008300 Walker A motif; other site 511145008301 ATP binding site [chemical binding]; other site 511145008302 Walker B motif; other site 511145008303 arginine finger; other site 511145008304 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 511145008305 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511145008306 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511145008307 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 511145008308 iron binding site [ion binding]; other site 511145008309 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 511145008310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145008311 Acylphosphatase; Region: Acylphosphatase; pfam00708 511145008312 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 511145008313 HypF finger; Region: zf-HYPF; pfam07503 511145008314 HypF finger; Region: zf-HYPF; pfam07503 511145008315 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 511145008316 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 511145008317 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145008318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511145008319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145008320 DNA binding site [nucleotide binding] 511145008321 domain linker motif; other site 511145008322 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 511145008323 dimerization interface (closed form) [polypeptide binding]; other site 511145008324 ligand binding site [chemical binding]; other site 511145008325 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 511145008326 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511145008327 active site turn [active] 511145008328 phosphorylation site [posttranslational modification] 511145008329 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 511145008330 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 511145008331 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 511145008332 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 511145008333 nickel binding site [ion binding]; other site 511145008334 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 511145008335 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 511145008336 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 511145008337 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145008338 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 511145008339 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 511145008340 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 511145008341 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 511145008342 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 511145008343 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511145008344 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 511145008345 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145008346 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145008347 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 511145008348 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 511145008349 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 511145008350 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511145008351 hydrogenase assembly chaperone; Provisional; Region: PRK10409 511145008352 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 511145008353 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 511145008354 dimerization interface [polypeptide binding]; other site 511145008355 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 511145008356 ATP binding site [chemical binding]; other site 511145008357 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 511145008358 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 511145008359 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 511145008360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145008361 Walker A motif; other site 511145008362 ATP binding site [chemical binding]; other site 511145008363 Walker B motif; other site 511145008364 arginine finger; other site 511145008365 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 511145008366 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 511145008367 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 511145008368 MutS domain I; Region: MutS_I; pfam01624 511145008369 MutS domain II; Region: MutS_II; pfam05188 511145008370 MutS domain III; Region: MutS_III; pfam05192 511145008371 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 511145008372 Walker A/P-loop; other site 511145008373 ATP binding site [chemical binding]; other site 511145008374 Q-loop/lid; other site 511145008375 ABC transporter signature motif; other site 511145008376 Walker B; other site 511145008377 D-loop; other site 511145008378 H-loop/switch region; other site 511145008379 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 511145008380 active site 511145008381 metal binding site [ion binding]; metal-binding site 511145008382 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511145008383 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 511145008384 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145008385 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 511145008386 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 511145008387 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 511145008388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 511145008389 putative aldolase; Validated; Region: PRK08130 511145008390 intersubunit interface [polypeptide binding]; other site 511145008391 active site 511145008392 Zn2+ binding site [ion binding]; other site 511145008393 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 511145008394 hypothetical protein; Provisional; Region: PRK09989 511145008395 putative transporter; Provisional; Region: PRK09821 511145008396 GntP family permease; Region: GntP_permease; pfam02447 511145008397 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 511145008398 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 511145008399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511145008400 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 511145008401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511145008402 DNA binding residues [nucleotide binding] 511145008403 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 511145008404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511145008405 Peptidase family M23; Region: Peptidase_M23; pfam01551 511145008406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145008407 S-adenosylmethionine binding site [chemical binding]; other site 511145008408 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 511145008409 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 511145008410 Permutation of conserved domain; other site 511145008411 active site 511145008412 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 511145008413 homotrimer interaction site [polypeptide binding]; other site 511145008414 zinc binding site [ion binding]; other site 511145008415 CDP-binding sites; other site 511145008416 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 511145008417 substrate binding site; other site 511145008418 dimer interface; other site 511145008419 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 511145008420 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 511145008421 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 511145008422 ligand-binding site [chemical binding]; other site 511145008423 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 511145008424 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 511145008425 CysD dimerization site [polypeptide binding]; other site 511145008426 G1 box; other site 511145008427 putative GEF interaction site [polypeptide binding]; other site 511145008428 GTP/Mg2+ binding site [chemical binding]; other site 511145008429 Switch I region; other site 511145008430 G2 box; other site 511145008431 G3 box; other site 511145008432 Switch II region; other site 511145008433 G4 box; other site 511145008434 G5 box; other site 511145008435 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 511145008436 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 511145008437 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 511145008438 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 511145008439 Active Sites [active] 511145008440 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 511145008441 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 511145008442 metal binding site [ion binding]; metal-binding site 511145008443 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 511145008444 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 511145008445 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 511145008446 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 511145008447 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 511145008448 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 511145008449 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 511145008450 helicase Cas3; Provisional; Region: PRK09694 511145008451 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 511145008452 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 511145008453 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 511145008454 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 511145008455 Active Sites [active] 511145008456 sulfite reductase subunit beta; Provisional; Region: PRK13504 511145008457 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 511145008458 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 511145008459 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 511145008460 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145008461 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 511145008462 Flavodoxin; Region: Flavodoxin_1; pfam00258 511145008463 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 511145008464 FAD binding pocket [chemical binding]; other site 511145008465 FAD binding motif [chemical binding]; other site 511145008466 catalytic residues [active] 511145008467 NAD binding pocket [chemical binding]; other site 511145008468 phosphate binding motif [ion binding]; other site 511145008469 beta-alpha-beta structure motif; other site 511145008470 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 511145008471 homohexamer interface [polypeptide binding]; other site 511145008472 putative substrate stabilizing pore; other site 511145008473 pterin binding site; other site 511145008474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145008475 putative oxidoreductase FixC; Provisional; Region: PRK10157 511145008476 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 511145008477 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 511145008478 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 511145008479 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 511145008480 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 511145008481 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 511145008482 Ligand binding site [chemical binding]; other site 511145008483 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 511145008484 benzoate transport; Region: 2A0115; TIGR00895 511145008485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145008486 putative substrate translocation pore; other site 511145008487 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 511145008488 FAD binding domain; Region: FAD_binding_4; pfam01565 511145008489 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 511145008490 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 511145008491 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 511145008492 NADP binding site [chemical binding]; other site 511145008493 homodimer interface [polypeptide binding]; other site 511145008494 active site 511145008495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511145008496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145008497 putative substrate translocation pore; other site 511145008498 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 511145008499 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 511145008500 nucleotide binding site [chemical binding]; other site 511145008501 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 511145008502 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 511145008503 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 511145008504 enolase; Provisional; Region: eno; PRK00077 511145008505 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 511145008506 dimer interface [polypeptide binding]; other site 511145008507 metal binding site [ion binding]; metal-binding site 511145008508 substrate binding pocket [chemical binding]; other site 511145008509 CTP synthetase; Validated; Region: pyrG; PRK05380 511145008510 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 511145008511 Catalytic site [active] 511145008512 active site 511145008513 UTP binding site [chemical binding]; other site 511145008514 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 511145008515 active site 511145008516 putative oxyanion hole; other site 511145008517 catalytic triad [active] 511145008518 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 511145008519 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 511145008520 homodimer interface [polypeptide binding]; other site 511145008521 metal binding site [ion binding]; metal-binding site 511145008522 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 511145008523 homodimer interface [polypeptide binding]; other site 511145008524 active site 511145008525 putative chemical substrate binding site [chemical binding]; other site 511145008526 metal binding site [ion binding]; metal-binding site 511145008527 toxin MazF; Provisional; Region: PRK09907 511145008528 antitoxin MazE; Provisional; Region: PRK09798 511145008529 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 511145008530 HD domain; Region: HD_4; pfam13328 511145008531 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511145008532 synthetase active site [active] 511145008533 NTP binding site [chemical binding]; other site 511145008534 metal binding site [ion binding]; metal-binding site 511145008535 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 511145008536 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 511145008537 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 511145008538 TRAM domain; Region: TRAM; pfam01938 511145008539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145008540 S-adenosylmethionine binding site [chemical binding]; other site 511145008541 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 511145008542 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 511145008543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145008544 dimerization interface [polypeptide binding]; other site 511145008545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145008546 dimer interface [polypeptide binding]; other site 511145008547 phosphorylation site [posttranslational modification] 511145008548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145008549 ATP binding site [chemical binding]; other site 511145008550 Mg2+ binding site [ion binding]; other site 511145008551 G-X-G motif; other site 511145008552 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 511145008553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145008554 active site 511145008555 phosphorylation site [posttranslational modification] 511145008556 intermolecular recognition site; other site 511145008557 dimerization interface [polypeptide binding]; other site 511145008558 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 511145008559 putative binding surface; other site 511145008560 active site 511145008561 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 511145008562 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 511145008563 active site 511145008564 tetramer interface [polypeptide binding]; other site 511145008565 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 511145008566 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 511145008567 active site 511145008568 tetramer interface [polypeptide binding]; other site 511145008569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145008570 D-galactonate transporter; Region: 2A0114; TIGR00893 511145008571 putative substrate translocation pore; other site 511145008572 flavodoxin; Provisional; Region: PRK08105 511145008573 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511145008574 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 511145008575 probable active site [active] 511145008576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 511145008577 SecY interacting protein Syd; Provisional; Region: PRK04968 511145008578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 511145008579 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 511145008580 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 511145008581 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 511145008582 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 511145008583 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 511145008584 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 511145008585 serine transporter; Region: stp; TIGR00814 511145008586 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 511145008587 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 511145008588 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 511145008589 flap endonuclease-like protein; Provisional; Region: PRK09482 511145008590 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 511145008591 active site 511145008592 metal binding site 1 [ion binding]; metal-binding site 511145008593 putative 5' ssDNA interaction site; other site 511145008594 metal binding site 3; metal-binding site 511145008595 metal binding site 2 [ion binding]; metal-binding site 511145008596 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 511145008597 putative DNA binding site [nucleotide binding]; other site 511145008598 putative metal binding site [ion binding]; other site 511145008599 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 511145008600 dimer interface [polypeptide binding]; other site 511145008601 active site 511145008602 metal binding site [ion binding]; metal-binding site 511145008603 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 511145008604 intersubunit interface [polypeptide binding]; other site 511145008605 active site 511145008606 Zn2+ binding site [ion binding]; other site 511145008607 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 511145008608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145008609 putative substrate translocation pore; other site 511145008610 L-fucose isomerase; Provisional; Region: fucI; PRK10991 511145008611 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 511145008612 hexamer (dimer of trimers) interface [polypeptide binding]; other site 511145008613 trimer interface [polypeptide binding]; other site 511145008614 substrate binding site [chemical binding]; other site 511145008615 Mn binding site [ion binding]; other site 511145008616 L-fuculokinase; Provisional; Region: PRK10331 511145008617 L-fuculose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_FK; cd07773 511145008618 putative N- and C-terminal domain interface [polypeptide binding]; other site 511145008619 putative active site [active] 511145008620 putative MgATP binding site [chemical binding]; other site 511145008621 putative catalytic site [active] 511145008622 metal binding site [ion binding]; metal-binding site 511145008623 putative carbohydrate binding site [chemical binding]; other site 511145008624 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 511145008625 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 511145008626 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 511145008627 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145008628 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 511145008629 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 511145008630 hypothetical protein; Provisional; Region: PRK10873 511145008631 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 511145008632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145008633 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 511145008634 dimerization interface [polypeptide binding]; other site 511145008635 substrate binding pocket [chemical binding]; other site 511145008636 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 511145008637 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 511145008638 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 511145008639 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511145008640 catalytic residue [active] 511145008641 CsdA-binding activator; Provisional; Region: PRK15019 511145008642 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 511145008643 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 511145008644 putative ATP binding site [chemical binding]; other site 511145008645 putative substrate interface [chemical binding]; other site 511145008646 murein transglycosylase A; Provisional; Region: mltA; PRK11162 511145008647 MltA specific insert domain; Region: MltA; smart00925 511145008648 3D domain; Region: 3D; pfam06725 511145008649 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 511145008650 AMIN domain; Region: AMIN; pfam11741 511145008651 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511145008652 active site 511145008653 metal binding site [ion binding]; metal-binding site 511145008654 N-acetylglutamate synthase; Validated; Region: PRK05279 511145008655 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 511145008656 putative feedback inhibition sensing region; other site 511145008657 putative nucleotide binding site [chemical binding]; other site 511145008658 putative substrate binding site [chemical binding]; other site 511145008659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145008660 Coenzyme A binding pocket [chemical binding]; other site 511145008661 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 511145008662 Helicase; Region: Helicase_RecD; pfam05127 511145008663 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 511145008664 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 511145008665 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 511145008666 protease3; Provisional; Region: PRK15101 511145008667 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 511145008668 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511145008669 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511145008670 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 511145008671 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 511145008672 hypothetical protein; Provisional; Region: PRK10332 511145008673 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 511145008674 hypothetical protein; Provisional; Region: PRK11521 511145008675 hypothetical protein; Provisional; Region: PRK10557 511145008676 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 511145008677 hypothetical protein; Provisional; Region: PRK10506 511145008678 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 511145008679 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 511145008680 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 511145008681 dimerization interface [polypeptide binding]; other site 511145008682 active site 511145008683 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 511145008684 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 511145008685 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 511145008686 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 511145008687 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511145008688 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511145008689 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 511145008690 putative active site [active] 511145008691 Ap4A binding site [chemical binding]; other site 511145008692 nudix motif; other site 511145008693 putative metal binding site [ion binding]; other site 511145008694 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 511145008695 putative DNA-binding cleft [nucleotide binding]; other site 511145008696 putative DNA clevage site; other site 511145008697 molecular lever; other site 511145008698 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 511145008699 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 511145008700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511145008701 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 511145008702 active site 511145008703 catalytic tetrad [active] 511145008704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145008705 putative substrate translocation pore; other site 511145008706 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 511145008707 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511145008708 putative acyl-acceptor binding pocket; other site 511145008709 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 511145008710 acyl-activating enzyme (AAE) consensus motif; other site 511145008711 putative AMP binding site [chemical binding]; other site 511145008712 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 511145008713 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145008714 DNA binding site [nucleotide binding] 511145008715 domain linker motif; other site 511145008716 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 511145008717 dimerization interface (closed form) [polypeptide binding]; other site 511145008718 ligand binding site [chemical binding]; other site 511145008719 diaminopimelate decarboxylase; Provisional; Region: PRK11165 511145008720 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 511145008721 active site 511145008722 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511145008723 substrate binding site [chemical binding]; other site 511145008724 catalytic residues [active] 511145008725 dimer interface [polypeptide binding]; other site 511145008726 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 511145008727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145008728 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 511145008729 putative dimerization interface [polypeptide binding]; other site 511145008730 putative racemase; Provisional; Region: PRK10200 511145008731 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 511145008732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145008733 putative substrate translocation pore; other site 511145008734 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 511145008735 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 511145008736 NADP binding site [chemical binding]; other site 511145008737 homodimer interface [polypeptide binding]; other site 511145008738 active site 511145008739 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 511145008740 putative acyltransferase; Provisional; Region: PRK05790 511145008741 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 511145008742 dimer interface [polypeptide binding]; other site 511145008743 active site 511145008744 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 511145008745 serine transporter; Region: stp; TIGR00814 511145008746 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 511145008747 DNA binding residues [nucleotide binding] 511145008748 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 511145008749 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 511145008750 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 511145008751 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 511145008752 Tetratricopeptide repeat; Region: TPR_3; pfam07720 511145008753 Tetratricopeptide repeat; Region: TPR_3; pfam07720 511145008754 transcriptional regulator; Provisional; Region: PRK11906 511145008755 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 511145008756 DNA binding site [nucleotide binding] 511145008757 Tetratricopeptide repeat; Region: TPR_2; pfam07719 511145008758 IS2 transposase TnpB; Reviewed; Region: PRK09409 511145008759 HTH-like domain; Region: HTH_21; pfam13276 511145008760 Integrase core domain; Region: rve; pfam00665 511145008761 Integrase core domain; Region: rve_3; pfam13683 511145008762 IS2 repressor TnpA; Reviewed; Region: PRK09413 511145008763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145008764 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 511145008765 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511145008766 Peptidase family M23; Region: Peptidase_M23; pfam01551 511145008767 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 511145008768 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 511145008769 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 511145008770 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 511145008771 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 511145008772 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 511145008773 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 511145008774 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511145008775 catalytic loop [active] 511145008776 iron binding site [ion binding]; other site 511145008777 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 511145008778 GAF domain; Region: GAF; cl17456 511145008779 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 511145008780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145008781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145008782 Walker A motif; other site 511145008783 ATP binding site [chemical binding]; other site 511145008784 Walker B motif; other site 511145008785 arginine finger; other site 511145008786 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511145008787 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 511145008788 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511145008789 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511145008790 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 511145008791 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511145008792 catalytic residue [active] 511145008793 peptidase; Reviewed; Region: PRK13004 511145008794 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 511145008795 putative metal binding site [ion binding]; other site 511145008796 putative dimer interface [polypeptide binding]; other site 511145008797 D-hydantoinase; Region: D-hydantoinase; TIGR02033 511145008798 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 511145008799 tetramer interface [polypeptide binding]; other site 511145008800 active site 511145008801 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 511145008802 putative substrate binding site [chemical binding]; other site 511145008803 nucleotide binding site [chemical binding]; other site 511145008804 nucleotide binding site [chemical binding]; other site 511145008805 homodimer interface [polypeptide binding]; other site 511145008806 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 511145008807 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 511145008808 XdhC Rossmann domain; Region: XdhC_C; pfam13478 511145008809 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 511145008810 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 511145008811 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 511145008812 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 511145008813 Ligand binding site; other site 511145008814 metal-binding site 511145008815 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 511145008816 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 511145008817 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145008818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145008819 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 511145008820 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 511145008821 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 511145008822 active site 511145008823 putative substrate binding pocket [chemical binding]; other site 511145008824 FAD binding domain; Region: FAD_binding_4; cl19922 511145008825 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 511145008826 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 511145008827 probable selenate reductase, molybdenum-binding subunit; Region: Se_sel_red_Mo; TIGR03313 511145008828 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 511145008829 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 511145008830 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 511145008831 uracil-xanthine permease; Region: ncs2; TIGR00801 511145008832 Sulfate transporter family; Region: Sulfate_transp; cl19250 511145008833 guanine deaminase; Provisional; Region: PRK09228 511145008834 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 511145008835 active site 511145008836 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 511145008837 Sulfate transporter family; Region: Sulfate_transp; cl19250 511145008838 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 511145008839 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145008840 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 511145008841 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145008842 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 511145008843 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 511145008844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 511145008845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145008846 Sulfate transporter family; Region: Sulfate_transp; cl19250 511145008847 xanthine permease; Region: pbuX; TIGR03173 511145008848 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 511145008849 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 511145008850 active site 511145008851 metal binding site [ion binding]; metal-binding site 511145008852 nudix motif; other site 511145008853 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 511145008854 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 511145008855 dimer interface [polypeptide binding]; other site 511145008856 putative anticodon binding site; other site 511145008857 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 511145008858 motif 1; other site 511145008859 active site 511145008860 motif 2; other site 511145008861 motif 3; other site 511145008862 peptide chain release factor 2; Validated; Region: prfB; PRK00578 511145008863 This domain is found in peptide chain release factors; Region: PCRF; smart00937 511145008864 RF-1 domain; Region: RF-1; pfam00472 511145008865 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 511145008866 DHH family; Region: DHH; pfam01368 511145008867 DHHA1 domain; Region: DHHA1; pfam02272 511145008868 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 511145008869 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 511145008870 dimerization domain [polypeptide binding]; other site 511145008871 dimer interface [polypeptide binding]; other site 511145008872 catalytic residues [active] 511145008873 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 511145008874 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 511145008875 active site 511145008876 Int/Topo IB signature motif; other site 511145008877 flavodoxin FldB; Provisional; Region: PRK12359 511145008878 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 511145008879 hypothetical protein; Provisional; Region: PRK10878 511145008880 putative global regulator; Reviewed; Region: PRK09559 511145008881 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 511145008882 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 511145008883 hemolysin; Provisional; Region: PRK15087 511145008884 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 511145008885 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 511145008886 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 511145008887 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 511145008888 classical (c) SDRs; Region: SDR_c; cd05233 511145008889 NAD(P) binding site [chemical binding]; other site 511145008890 active site 511145008891 glycine dehydrogenase; Provisional; Region: PRK05367 511145008892 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 511145008893 tetramer interface [polypeptide binding]; other site 511145008894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145008895 catalytic residue [active] 511145008896 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 511145008897 tetramer interface [polypeptide binding]; other site 511145008898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145008899 catalytic residue [active] 511145008900 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511145008901 lipoyl attachment site [posttranslational modification]; other site 511145008902 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 511145008903 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 511145008904 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 511145008905 oxidoreductase; Provisional; Region: PRK08013 511145008906 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 511145008907 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 511145008908 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 511145008909 proline aminopeptidase P II; Provisional; Region: PRK10879 511145008910 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 511145008911 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 511145008912 active site 511145008913 hypothetical protein; Reviewed; Region: PRK01736 511145008914 Z-ring-associated protein; Provisional; Region: PRK10972 511145008915 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 511145008916 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 511145008917 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 511145008918 ligand binding site [chemical binding]; other site 511145008919 NAD binding site [chemical binding]; other site 511145008920 tetramer interface [polypeptide binding]; other site 511145008921 catalytic site [active] 511145008922 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 511145008923 L-serine binding site [chemical binding]; other site 511145008924 ACT domain interface; other site 511145008925 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 511145008926 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511145008927 active site 511145008928 dimer interface [polypeptide binding]; other site 511145008929 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 511145008930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145008931 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 511145008932 putative dimerization interface [polypeptide binding]; other site 511145008933 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 511145008934 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 511145008935 active site 511145008936 substrate binding site [chemical binding]; other site 511145008937 coenzyme B12 binding site [chemical binding]; other site 511145008938 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 511145008939 B12 binding site [chemical binding]; other site 511145008940 cobalt ligand [ion binding]; other site 511145008941 LAO/AO transport system ATPase; Region: lao; TIGR00750 511145008942 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 511145008943 Walker A; other site 511145008944 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 511145008945 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511145008946 substrate binding site [chemical binding]; other site 511145008947 oxyanion hole (OAH) forming residues; other site 511145008948 trimer interface [polypeptide binding]; other site 511145008949 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 511145008950 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 511145008951 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 511145008952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145008953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145008954 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511145008955 dimerization interface [polypeptide binding]; other site 511145008956 oxidative stress defense protein; Provisional; Region: PRK11087 511145008957 arginine exporter protein; Provisional; Region: PRK09304 511145008958 mechanosensitive channel MscS; Provisional; Region: PRK10334 511145008959 Conserved TM helix; Region: TM_helix; pfam05552 511145008960 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511145008961 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 511145008962 active site 511145008963 intersubunit interface [polypeptide binding]; other site 511145008964 zinc binding site [ion binding]; other site 511145008965 Na+ binding site [ion binding]; other site 511145008966 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 511145008967 substrate binding site [chemical binding]; other site 511145008968 hinge regions; other site 511145008969 ADP binding site [chemical binding]; other site 511145008970 catalytic site [active] 511145008971 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 511145008972 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 511145008973 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 511145008974 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 511145008975 active site 511145008976 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 511145008977 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 511145008978 putative active site [active] 511145008979 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 511145008980 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511145008981 putative NAD(P) binding site [chemical binding]; other site 511145008982 catalytic Zn binding site [ion binding]; other site 511145008983 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 511145008984 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 511145008985 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 511145008986 active site 511145008987 P-loop; other site 511145008988 phosphorylation site [posttranslational modification] 511145008989 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145008990 active site 511145008991 phosphorylation site [posttranslational modification] 511145008992 transketolase; Reviewed; Region: PRK12753 511145008993 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 511145008994 TPP-binding site [chemical binding]; other site 511145008995 dimer interface [polypeptide binding]; other site 511145008996 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 511145008997 PYR/PP interface [polypeptide binding]; other site 511145008998 dimer interface [polypeptide binding]; other site 511145008999 TPP binding site [chemical binding]; other site 511145009000 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511145009001 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 511145009002 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 511145009003 oligomer interface [polypeptide binding]; other site 511145009004 putative active site [active] 511145009005 Mn binding site [ion binding]; other site 511145009006 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 511145009007 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 511145009008 dimer interface [polypeptide binding]; other site 511145009009 active site 511145009010 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511145009011 catalytic residues [active] 511145009012 substrate binding site [chemical binding]; other site 511145009013 Virulence promoting factor; Region: YqgB; pfam11036 511145009014 S-adenosylmethionine synthetase; Validated; Region: PRK05250 511145009015 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 511145009016 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 511145009017 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 511145009018 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 511145009019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145009020 putative substrate translocation pore; other site 511145009021 hypothetical protein; Provisional; Region: PRK04860 511145009022 DNA-specific endonuclease I; Provisional; Region: PRK15137 511145009023 RNA methyltransferase, RsmE family; Region: TIGR00046 511145009024 glutathione synthetase; Provisional; Region: PRK05246 511145009025 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 511145009026 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 511145009027 hypothetical protein; Validated; Region: PRK00228 511145009028 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 511145009029 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 511145009030 Walker A motif; other site 511145009031 ATP binding site [chemical binding]; other site 511145009032 Walker B motif; other site 511145009033 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 511145009034 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511145009035 catalytic residue [active] 511145009036 YGGT family; Region: YGGT; pfam02325 511145009037 Predicted integral membrane protein [Function unknown]; Region: COG0762 511145009038 hypothetical protein; Validated; Region: PRK05090 511145009039 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 511145009040 active site 511145009041 dimerization interface [polypeptide binding]; other site 511145009042 HemN family oxidoreductase; Provisional; Region: PRK05660 511145009043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145009044 FeS/SAM binding site; other site 511145009045 HemN C-terminal domain; Region: HemN_C; pfam06969 511145009046 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 511145009047 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 511145009048 active site 511145009049 homodimer interface [polypeptide binding]; other site 511145009050 hypothetical protein; Provisional; Region: PRK10626 511145009051 hypothetical protein; Provisional; Region: PRK11702 511145009052 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 511145009053 adenine DNA glycosylase; Provisional; Region: PRK10880 511145009054 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511145009055 minor groove reading motif; other site 511145009056 helix-hairpin-helix signature motif; other site 511145009057 substrate binding pocket [chemical binding]; other site 511145009058 active site 511145009059 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 511145009060 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 511145009061 DNA binding and oxoG recognition site [nucleotide binding] 511145009062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 511145009063 murein transglycosylase C; Provisional; Region: mltC; PRK11671 511145009064 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 511145009065 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 511145009066 N-acetyl-D-glucosamine binding site [chemical binding]; other site 511145009067 catalytic residue [active] 511145009068 nucleoside transporter; Region: 2A0110; TIGR00889 511145009069 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 511145009070 ornithine decarboxylase; Provisional; Region: PRK13578 511145009071 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 511145009072 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 511145009073 homodimer interface [polypeptide binding]; other site 511145009074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145009075 catalytic residue [active] 511145009076 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 511145009077 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 511145009078 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 511145009079 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 511145009080 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 511145009081 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 511145009082 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 511145009083 Peptidase M60-like family; Region: M60-like; pfam13402 511145009084 glycolate transporter; Provisional; Region: PRK09695 511145009085 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 511145009086 active site 511145009087 hypothetical protein; Provisional; Region: PRK09732 511145009088 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 511145009089 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 511145009090 Cysteine-rich domain; Region: CCG; pfam02754 511145009091 Cysteine-rich domain; Region: CCG; pfam02754 511145009092 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 511145009093 FAD binding domain; Region: FAD_binding_4; cl19922 511145009094 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 511145009095 FAD binding domain; Region: FAD_binding_4; pfam01565 511145009096 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 511145009097 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 511145009098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145009099 DNA-binding site [nucleotide binding]; DNA binding site 511145009100 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 511145009101 Transposase domain (DUF772); Region: DUF772; pfam05598 511145009102 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145009103 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145009104 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145009105 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 511145009106 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 511145009107 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 511145009108 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 511145009109 active site 511145009110 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 511145009111 TMP-binding site; other site 511145009112 ATP-binding site [chemical binding]; other site 511145009113 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 511145009114 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 511145009115 TMP-binding site; other site 511145009116 ATP-binding site [chemical binding]; other site 511145009117 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 511145009118 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 511145009119 CHAP domain; Region: CHAP; pfam05257 511145009120 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 511145009121 putative S-transferase; Provisional; Region: PRK11752 511145009122 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 511145009123 C-terminal domain interface [polypeptide binding]; other site 511145009124 GSH binding site (G-site) [chemical binding]; other site 511145009125 dimer interface [polypeptide binding]; other site 511145009126 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 511145009127 dimer interface [polypeptide binding]; other site 511145009128 N-terminal domain interface [polypeptide binding]; other site 511145009129 active site 511145009130 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 511145009131 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 511145009132 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 511145009133 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 511145009134 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 511145009135 putative substrate-binding site; other site 511145009136 nickel binding site [ion binding]; other site 511145009137 hydrogenase 2 large subunit; Provisional; Region: PRK10467 511145009138 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 511145009139 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 511145009140 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145009141 hydrogenase 2 small subunit; Provisional; Region: PRK10468 511145009142 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 511145009143 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 511145009144 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 511145009145 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 511145009146 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511145009147 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 511145009148 active site 511145009149 catalytic tetrad [active] 511145009150 hypothetical protein; Provisional; Region: PRK05208 511145009151 oxidoreductase; Provisional; Region: PRK07985 511145009152 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 511145009153 NAD binding site [chemical binding]; other site 511145009154 metal binding site [ion binding]; metal-binding site 511145009155 active site 511145009156 biopolymer transport protein ExbD; Provisional; Region: PRK11267 511145009157 biopolymer transport protein ExbB; Provisional; Region: PRK10414 511145009158 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511145009159 homodimer interface [polypeptide binding]; other site 511145009160 substrate-cofactor binding pocket; other site 511145009161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145009162 catalytic residue [active] 511145009163 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 511145009164 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 511145009165 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 511145009166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145009167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145009168 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 511145009169 dimer interface [polypeptide binding]; other site 511145009170 active site 511145009171 metal binding site [ion binding]; metal-binding site 511145009172 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511145009173 active site 511145009174 catalytic tetrad [active] 511145009175 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 511145009176 putative outer membrane lipoprotein; Provisional; Region: PRK09973 511145009177 hypothetical protein; Provisional; Region: PRK01254 511145009178 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 511145009179 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 511145009180 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 511145009181 FtsI repressor; Provisional; Region: PRK10883 511145009182 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 511145009183 Domain 2 interface [polypeptide binding]; other site 511145009184 Domain 3 interface [polypeptide binding]; other site 511145009185 trinuclear Cu binding site [ion binding]; other site 511145009186 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 511145009187 Domain 1 interface [polypeptide binding]; other site 511145009188 Domain 3 interface [polypeptide binding]; other site 511145009189 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 511145009190 Domain 2 interface [polypeptide binding]; other site 511145009191 Domain 1 interface [polypeptide binding]; other site 511145009192 Type 1 (T1) Cu binding site [ion binding]; other site 511145009193 trinuclear Cu binding site [ion binding]; other site 511145009194 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511145009195 putative acyl-acceptor binding pocket; other site 511145009196 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 511145009197 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 511145009198 CAP-like domain; other site 511145009199 active site 511145009200 primary dimer interface [polypeptide binding]; other site 511145009201 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511145009202 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 511145009203 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511145009204 peptide binding site [polypeptide binding]; other site 511145009205 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 511145009206 toxin interface [polypeptide binding]; other site 511145009207 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 511145009208 Zn binding site [ion binding]; other site 511145009209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145009210 non-specific DNA binding site [nucleotide binding]; other site 511145009211 salt bridge; other site 511145009212 sequence-specific DNA binding site [nucleotide binding]; other site 511145009213 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 511145009214 peptide binding site [polypeptide binding]; other site 511145009215 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 511145009216 TIGR00156 family protein; Region: TIGR00156 511145009217 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 511145009218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145009219 active site 511145009220 phosphorylation site [posttranslational modification] 511145009221 intermolecular recognition site; other site 511145009222 dimerization interface [polypeptide binding]; other site 511145009223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145009224 DNA binding site [nucleotide binding] 511145009225 sensor protein QseC; Provisional; Region: PRK10337 511145009226 HAMP domain; Region: HAMP; pfam00672 511145009227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145009228 dimer interface [polypeptide binding]; other site 511145009229 phosphorylation site [posttranslational modification] 511145009230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145009231 ATP binding site [chemical binding]; other site 511145009232 Mg2+ binding site [ion binding]; other site 511145009233 G-X-G motif; other site 511145009234 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 511145009235 Uncharacterized conserved protein [Function unknown]; Region: COG1359 511145009236 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 511145009237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145009238 ATP binding site [chemical binding]; other site 511145009239 Mg2+ binding site [ion binding]; other site 511145009240 G-X-G motif; other site 511145009241 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511145009242 anchoring element; other site 511145009243 dimer interface [polypeptide binding]; other site 511145009244 ATP binding site [chemical binding]; other site 511145009245 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 511145009246 active site 511145009247 metal binding site [ion binding]; metal-binding site 511145009248 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511145009249 esterase YqiA; Provisional; Region: PRK11071 511145009250 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511145009251 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 511145009252 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 511145009253 active site 511145009254 metal binding site [ion binding]; metal-binding site 511145009255 hexamer interface [polypeptide binding]; other site 511145009256 putative dehydrogenase; Provisional; Region: PRK11039 511145009257 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 511145009258 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511145009259 dimer interface [polypeptide binding]; other site 511145009260 ADP-ribose binding site [chemical binding]; other site 511145009261 active site 511145009262 nudix motif; other site 511145009263 metal binding site [ion binding]; metal-binding site 511145009264 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 511145009265 Outer membrane efflux protein; Region: OEP; pfam02321 511145009266 Outer membrane efflux protein; Region: OEP; pfam02321 511145009267 hypothetical protein; Provisional; Region: PRK11653 511145009268 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 511145009269 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 511145009270 putative active site [active] 511145009271 metal binding site [ion binding]; metal-binding site 511145009272 zinc transporter ZupT; Provisional; Region: PRK04201 511145009273 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 511145009274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 511145009275 putative fimbrial protein; Provisional; Region: PRK09733 511145009276 IS2 repressor TnpA; Reviewed; Region: PRK09413 511145009277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145009278 IS2 transposase TnpB; Reviewed; Region: PRK09409 511145009279 HTH-like domain; Region: HTH_21; pfam13276 511145009280 Integrase core domain; Region: rve; pfam00665 511145009281 Integrase core domain; Region: rve_3; pfam13683 511145009282 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 511145009283 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145009284 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145009285 Fimbrial protein; Region: Fimbrial; pfam00419 511145009286 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 511145009287 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 511145009288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 511145009289 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 511145009290 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 511145009291 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 511145009292 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 511145009293 putative ribose interaction site [chemical binding]; other site 511145009294 putative ADP binding site [chemical binding]; other site 511145009295 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 511145009296 active site 511145009297 nucleotide binding site [chemical binding]; other site 511145009298 HIGH motif; other site 511145009299 KMSKS motif; other site 511145009300 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 511145009301 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 511145009302 metal binding triad; other site 511145009303 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 511145009304 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 511145009305 metal binding triad; other site 511145009306 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 511145009307 Uncharacterized conserved protein [Function unknown]; Region: COG3025 511145009308 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 511145009309 putative active site [active] 511145009310 putative metal binding residues [ion binding]; other site 511145009311 signature motif; other site 511145009312 putative triphosphate binding site [ion binding]; other site 511145009313 CHAD domain; Region: CHAD; pfam05235 511145009314 SH3 domain-containing protein; Provisional; Region: PRK10884 511145009315 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 511145009316 Bacterial SH3 domain homologues; Region: SH3b; smart00287 511145009317 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 511145009318 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 511145009319 active site 511145009320 NTP binding site [chemical binding]; other site 511145009321 metal binding triad [ion binding]; metal-binding site 511145009322 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 511145009323 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511145009324 Zn2+ binding site [ion binding]; other site 511145009325 Mg2+ binding site [ion binding]; other site 511145009326 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 511145009327 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 511145009328 homooctamer interface [polypeptide binding]; other site 511145009329 active site 511145009330 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 511145009331 transcriptional activator TtdR; Provisional; Region: PRK09801 511145009332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145009333 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 511145009334 putative effector binding pocket; other site 511145009335 putative dimerization interface [polypeptide binding]; other site 511145009336 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 511145009337 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 511145009338 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 511145009339 anion transporter; Region: dass; TIGR00785 511145009340 transmembrane helices; other site 511145009341 UGMP family protein; Validated; Region: PRK09604 511145009342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145009343 nucleotide binding site [chemical binding]; other site 511145009344 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 511145009345 DNA primase; Validated; Region: dnaG; PRK05667 511145009346 CHC2 zinc finger; Region: zf-CHC2; pfam01807 511145009347 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 511145009348 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 511145009349 active site 511145009350 metal binding site [ion binding]; metal-binding site 511145009351 interdomain interaction site; other site 511145009352 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 511145009353 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 511145009354 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 511145009355 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 511145009356 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 511145009357 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 511145009358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511145009359 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 511145009360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511145009361 DNA binding residues [nucleotide binding] 511145009362 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 511145009363 active site 511145009364 SUMO-1 interface [polypeptide binding]; other site 511145009365 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 511145009366 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 511145009367 FAD binding pocket [chemical binding]; other site 511145009368 FAD binding motif [chemical binding]; other site 511145009369 phosphate binding motif [ion binding]; other site 511145009370 NAD binding pocket [chemical binding]; other site 511145009371 Predicted transcriptional regulators [Transcription]; Region: COG1695 511145009372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145009373 PAS fold; Region: PAS_3; pfam08447 511145009374 putative active site [active] 511145009375 heme pocket [chemical binding]; other site 511145009376 HAMP domain; Region: HAMP; pfam00672 511145009377 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 511145009378 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 511145009379 dimer interface [polypeptide binding]; other site 511145009380 putative CheW interface [polypeptide binding]; other site 511145009381 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511145009382 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 511145009383 inhibitor-cofactor binding pocket; inhibition site 511145009384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145009385 catalytic residue [active] 511145009386 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 511145009387 dimer interface [polypeptide binding]; other site 511145009388 putative tRNA-binding site [nucleotide binding]; other site 511145009389 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 511145009390 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145009391 DNA binding site [nucleotide binding] 511145009392 domain linker motif; other site 511145009393 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 511145009394 putative dimerization interface [polypeptide binding]; other site 511145009395 putative ligand binding site [chemical binding]; other site 511145009396 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 511145009397 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 511145009398 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 511145009399 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 511145009400 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 511145009401 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 511145009402 inner membrane transporter YjeM; Provisional; Region: PRK15238 511145009403 alpha-glucosidase; Provisional; Region: PRK10137 511145009404 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 511145009405 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 511145009406 active site 511145009407 FMN binding site [chemical binding]; other site 511145009408 2,4-decadienoyl-CoA binding site; other site 511145009409 catalytic residue [active] 511145009410 4Fe-4S cluster binding site [ion binding]; other site 511145009411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145009412 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 511145009413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145009414 non-specific DNA binding site [nucleotide binding]; other site 511145009415 salt bridge; other site 511145009416 sequence-specific DNA binding site [nucleotide binding]; other site 511145009417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 511145009418 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 511145009419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145009420 S-adenosylmethionine binding site [chemical binding]; other site 511145009421 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 511145009422 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 511145009423 putative active site [active] 511145009424 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 511145009425 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 511145009426 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 511145009427 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 511145009428 serine/threonine transporter SstT; Provisional; Region: PRK13628 511145009429 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 511145009430 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 511145009431 galactarate dehydratase; Region: galactar-dH20; TIGR03248 511145009432 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 511145009433 glucuronate isomerase; Reviewed; Region: PRK02925 511145009434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145009435 D-galactonate transporter; Region: 2A0114; TIGR00893 511145009436 putative substrate translocation pore; other site 511145009437 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 511145009438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145009439 DNA-binding site [nucleotide binding]; DNA binding site 511145009440 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 511145009441 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 511145009442 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 511145009443 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 511145009444 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 511145009445 Predicted membrane protein [Function unknown]; Region: COG5393 511145009446 YqjK-like protein; Region: YqjK; pfam13997 511145009447 Predicted membrane protein [Function unknown]; Region: COG2259 511145009448 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 511145009449 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 511145009450 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 511145009451 putative dimer interface [polypeptide binding]; other site 511145009452 N-terminal domain interface [polypeptide binding]; other site 511145009453 putative substrate binding pocket (H-site) [chemical binding]; other site 511145009454 Predicted membrane protein [Function unknown]; Region: COG3152 511145009455 Predicted membrane protein [Function unknown]; Region: COG3152 511145009456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145009457 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 511145009458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145009459 dimerization interface [polypeptide binding]; other site 511145009460 Pirin-related protein [General function prediction only]; Region: COG1741 511145009461 Pirin; Region: Pirin; pfam02678 511145009462 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 511145009463 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 511145009464 serine transporter; Region: stp; TIGR00814 511145009465 L-serine dehydratase TdcG; Provisional; Region: PRK15040 511145009466 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 511145009467 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 511145009468 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 511145009469 homotrimer interaction site [polypeptide binding]; other site 511145009470 putative active site [active] 511145009471 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 511145009472 Pyruvate formate lyase 1; Region: PFL1; cd01678 511145009473 coenzyme A binding site [chemical binding]; other site 511145009474 active site 511145009475 catalytic residues [active] 511145009476 glycine loop; other site 511145009477 propionate/acetate kinase; Provisional; Region: PRK12379 511145009478 threonine/serine transporter TdcC; Provisional; Region: PRK13629 511145009479 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 511145009480 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 511145009481 tetramer interface [polypeptide binding]; other site 511145009482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145009483 catalytic residue [active] 511145009484 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 511145009485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145009486 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 511145009487 putative substrate binding pocket [chemical binding]; other site 511145009488 putative dimerization interface [polypeptide binding]; other site 511145009489 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 511145009490 hypothetical protein; Provisional; Region: PRK09716 511145009491 glycerate kinase I; Provisional; Region: PRK10342 511145009492 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 511145009493 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 511145009494 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 511145009495 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 511145009496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145009497 D-galactonate transporter; Region: 2A0114; TIGR00893 511145009498 putative substrate translocation pore; other site 511145009499 galactarate dehydratase; Region: galactar-dH20; TIGR03248 511145009500 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 511145009501 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 511145009502 putative regulator PrlF; Provisional; Region: PRK09974 511145009503 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 511145009504 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 511145009505 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 511145009506 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145009507 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 511145009508 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 511145009509 active site 511145009510 phosphorylation site [posttranslational modification] 511145009511 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 511145009512 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511145009513 dimer interface [polypeptide binding]; other site 511145009514 active site 511145009515 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 511145009516 putative active site [active] 511145009517 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 511145009518 active site 511145009519 intersubunit interface [polypeptide binding]; other site 511145009520 zinc binding site [ion binding]; other site 511145009521 Na+ binding site [ion binding]; other site 511145009522 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 511145009523 active site 511145009524 phosphorylation site [posttranslational modification] 511145009525 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 511145009526 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 511145009527 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 511145009528 active site 511145009529 trimer interface [polypeptide binding]; other site 511145009530 allosteric site; other site 511145009531 active site lid [active] 511145009532 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 511145009533 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 511145009534 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145009535 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145009536 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 511145009537 PapC N-terminal domain; Region: PapC_N; pfam13954 511145009538 Outer membrane usher protein; Region: Usher; pfam00577 511145009539 PapC C-terminal domain; Region: PapC_C; pfam13953 511145009540 Fimbrial protein; Region: Fimbrial; cl01416 511145009541 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 511145009542 putative SAM binding site [chemical binding]; other site 511145009543 putative homodimer interface [polypeptide binding]; other site 511145009544 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 511145009545 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 511145009546 putative ligand binding site [chemical binding]; other site 511145009547 TIGR00252 family protein; Region: TIGR00252 511145009548 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 511145009549 dimer interface [polypeptide binding]; other site 511145009550 active site 511145009551 outer membrane lipoprotein; Provisional; Region: PRK11023 511145009552 BON domain; Region: BON; pfam04972 511145009553 BON domain; Region: BON; pfam04972 511145009554 Predicted permease; Region: DUF318; pfam03773 511145009555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511145009556 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 511145009557 NAD(P) binding site [chemical binding]; other site 511145009558 active site 511145009559 intracellular protease, PfpI family; Region: PfpI; TIGR01382 511145009560 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 511145009561 proposed catalytic triad [active] 511145009562 conserved cys residue [active] 511145009563 hypothetical protein; Provisional; Region: PRK03467 511145009564 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 511145009565 GIY-YIG motif/motif A; other site 511145009566 putative active site [active] 511145009567 putative metal binding site [ion binding]; other site 511145009568 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511145009569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145009570 Coenzyme A binding pocket [chemical binding]; other site 511145009571 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 511145009572 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 511145009573 putative protease; Provisional; Region: PRK15447 511145009574 hypothetical protein; Provisional; Region: PRK10508 511145009575 tryptophan permease; Provisional; Region: PRK10483 511145009576 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 511145009577 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 511145009578 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511145009579 ATP binding site [chemical binding]; other site 511145009580 Mg++ binding site [ion binding]; other site 511145009581 motif III; other site 511145009582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145009583 nucleotide binding region [chemical binding]; other site 511145009584 ATP-binding site [chemical binding]; other site 511145009585 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 511145009586 putative RNA binding site [nucleotide binding]; other site 511145009587 lipoprotein NlpI; Provisional; Region: PRK11189 511145009588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145009589 binding surface 511145009590 TPR motif; other site 511145009591 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 511145009592 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 511145009593 RNase E interface [polypeptide binding]; other site 511145009594 trimer interface [polypeptide binding]; other site 511145009595 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 511145009596 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 511145009597 RNase E interface [polypeptide binding]; other site 511145009598 trimer interface [polypeptide binding]; other site 511145009599 active site 511145009600 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 511145009601 putative nucleic acid binding region [nucleotide binding]; other site 511145009602 G-X-X-G motif; other site 511145009603 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 511145009604 RNA binding site [nucleotide binding]; other site 511145009605 domain interface; other site 511145009606 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 511145009607 16S/18S rRNA binding site [nucleotide binding]; other site 511145009608 S13e-L30e interaction site [polypeptide binding]; other site 511145009609 25S rRNA binding site [nucleotide binding]; other site 511145009610 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 511145009611 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 511145009612 RNA binding site [nucleotide binding]; other site 511145009613 active site 511145009614 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 511145009615 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 511145009616 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511145009617 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 511145009618 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 511145009619 translation initiation factor IF-2; Validated; Region: infB; PRK05306 511145009620 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511145009621 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 511145009622 G1 box; other site 511145009623 putative GEF interaction site [polypeptide binding]; other site 511145009624 GTP/Mg2+ binding site [chemical binding]; other site 511145009625 Switch I region; other site 511145009626 G2 box; other site 511145009627 G3 box; other site 511145009628 Switch II region; other site 511145009629 G4 box; other site 511145009630 G5 box; other site 511145009631 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 511145009632 Translation-initiation factor 2; Region: IF-2; pfam11987 511145009633 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 511145009634 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 511145009635 NusA N-terminal domain; Region: NusA_N; pfam08529 511145009636 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 511145009637 RNA binding site [nucleotide binding]; other site 511145009638 homodimer interface [polypeptide binding]; other site 511145009639 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 511145009640 G-X-X-G motif; other site 511145009641 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 511145009642 G-X-X-G motif; other site 511145009643 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 511145009644 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 511145009645 hypothetical protein; Provisional; Region: PRK14641 511145009646 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 511145009647 putative oligomer interface [polypeptide binding]; other site 511145009648 putative RNA binding site [nucleotide binding]; other site 511145009649 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 511145009650 ANP binding site [chemical binding]; other site 511145009651 Substrate Binding Site II [chemical binding]; other site 511145009652 Substrate Binding Site I [chemical binding]; other site 511145009653 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 511145009654 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 511145009655 Sulfatase; Region: Sulfatase; pfam00884 511145009656 Preprotein translocase SecG subunit; Region: SecG; pfam03840 511145009657 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 511145009658 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 511145009659 active site 511145009660 substrate binding site [chemical binding]; other site 511145009661 metal binding site [ion binding]; metal-binding site 511145009662 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 511145009663 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 511145009664 substrate binding pocket [chemical binding]; other site 511145009665 dimer interface [polypeptide binding]; other site 511145009666 inhibitor binding site; inhibition site 511145009667 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 511145009668 FtsH Extracellular; Region: FtsH_ext; pfam06480 511145009669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145009670 Walker A motif; other site 511145009671 ATP binding site [chemical binding]; other site 511145009672 Walker B motif; other site 511145009673 arginine finger; other site 511145009674 Peptidase family M41; Region: Peptidase_M41; pfam01434 511145009675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145009676 S-adenosylmethionine binding site [chemical binding]; other site 511145009677 RNA-binding protein YhbY; Provisional; Region: PRK10343 511145009678 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 511145009679 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511145009680 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511145009681 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 511145009682 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 511145009683 GTPase CgtA; Reviewed; Region: obgE; PRK12298 511145009684 GTP1/OBG; Region: GTP1_OBG; pfam01018 511145009685 Obg GTPase; Region: Obg; cd01898 511145009686 G1 box; other site 511145009687 GTP/Mg2+ binding site [chemical binding]; other site 511145009688 Switch I region; other site 511145009689 G2 box; other site 511145009690 G3 box; other site 511145009691 Switch II region; other site 511145009692 G4 box; other site 511145009693 G5 box; other site 511145009694 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 511145009695 EamA-like transporter family; Region: EamA; pfam00892 511145009696 EamA-like transporter family; Region: EamA; pfam00892 511145009697 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 511145009698 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 511145009699 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511145009700 substrate binding pocket [chemical binding]; other site 511145009701 chain length determination region; other site 511145009702 substrate-Mg2+ binding site; other site 511145009703 catalytic residues [active] 511145009704 aspartate-rich region 1; other site 511145009705 active site lid residues [active] 511145009706 aspartate-rich region 2; other site 511145009707 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 511145009708 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 511145009709 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511145009710 hinge; other site 511145009711 active site 511145009712 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 511145009713 Predicted NTP binding protein (contains STAS domain) [General function prediction only]; Region: COG3113 511145009714 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 511145009715 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 511145009716 mce related protein; Region: MCE; pfam02470 511145009717 conserved hypothetical integral membrane protein; Region: TIGR00056 511145009718 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 511145009719 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 511145009720 Walker A/P-loop; other site 511145009721 ATP binding site [chemical binding]; other site 511145009722 Q-loop/lid; other site 511145009723 ABC transporter signature motif; other site 511145009724 Walker B; other site 511145009725 D-loop; other site 511145009726 H-loop/switch region; other site 511145009727 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 511145009728 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 511145009729 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 511145009730 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 511145009731 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 511145009732 putative active site [active] 511145009733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 511145009734 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 511145009735 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 511145009736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 511145009737 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 511145009738 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 511145009739 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 511145009740 Walker A/P-loop; other site 511145009741 ATP binding site [chemical binding]; other site 511145009742 Q-loop/lid; other site 511145009743 ABC transporter signature motif; other site 511145009744 Walker B; other site 511145009745 D-loop; other site 511145009746 H-loop/switch region; other site 511145009747 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 511145009748 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 511145009749 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 511145009750 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 511145009751 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 511145009752 30S subunit binding site; other site 511145009753 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145009754 active site 511145009755 phosphorylation site [posttranslational modification] 511145009756 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 511145009757 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511145009758 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511145009759 dimerization domain swap beta strand [polypeptide binding]; other site 511145009760 regulatory protein interface [polypeptide binding]; other site 511145009761 active site 511145009762 regulatory phosphorylation site [posttranslational modification]; other site 511145009763 hypothetical protein; Provisional; Region: PRK10345 511145009764 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 511145009765 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 511145009766 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 511145009767 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 511145009768 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 511145009769 conserved cys residue [active] 511145009770 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 511145009771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145009772 putative active site [active] 511145009773 heme pocket [chemical binding]; other site 511145009774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145009775 dimer interface [polypeptide binding]; other site 511145009776 phosphorylation site [posttranslational modification] 511145009777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145009778 ATP binding site [chemical binding]; other site 511145009779 Mg2+ binding site [ion binding]; other site 511145009780 G-X-G motif; other site 511145009781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145009782 active site 511145009783 phosphorylation site [posttranslational modification] 511145009784 intermolecular recognition site; other site 511145009785 dimerization interface [polypeptide binding]; other site 511145009786 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 511145009787 putative binding surface; other site 511145009788 active site 511145009789 radical SAM protein, TIGR01212 family; Region: TIGR01212 511145009790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145009791 FeS/SAM binding site; other site 511145009792 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 511145009793 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 511145009794 active site 511145009795 dimer interface [polypeptide binding]; other site 511145009796 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 511145009797 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 511145009798 active site 511145009799 FMN binding site [chemical binding]; other site 511145009800 substrate binding site [chemical binding]; other site 511145009801 3Fe-4S cluster binding site [ion binding]; other site 511145009802 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 511145009803 domain interface; other site 511145009804 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 511145009805 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 511145009806 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145009807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145009808 Protein of unknown function (DUF1120); Region: DUF1120; pfam06551 511145009809 putative fimbrial chaperone protein; Provisional; Region: PRK09918 511145009810 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145009811 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145009812 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 511145009813 PapC N-terminal domain; Region: PapC_N; pfam13954 511145009814 Outer membrane usher protein; Region: Usher; pfam00577 511145009815 PapC C-terminal domain; Region: PapC_C; pfam13953 511145009816 Transposase domain (DUF772); Region: DUF772; pfam05598 511145009817 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145009818 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145009819 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145009820 Protein of unknown function (DUF1120); Region: DUF1120; pfam06551 511145009821 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 511145009822 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 511145009823 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511145009824 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145009825 nucleotide binding site [chemical binding]; other site 511145009826 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 511145009827 putative active site cavity [active] 511145009828 putative sialic acid transporter; Provisional; Region: PRK03893 511145009829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145009830 putative substrate translocation pore; other site 511145009831 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 511145009832 inhibitor site; inhibition site 511145009833 active site 511145009834 dimer interface [polypeptide binding]; other site 511145009835 catalytic residue [active] 511145009836 transcriptional regulator NanR; Provisional; Region: PRK03837 511145009837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145009838 DNA-binding site [nucleotide binding]; DNA binding site 511145009839 FCD domain; Region: FCD; pfam07729 511145009840 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 511145009841 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 511145009842 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 511145009843 stringent starvation protein A; Provisional; Region: sspA; PRK09481 511145009844 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 511145009845 C-terminal domain interface [polypeptide binding]; other site 511145009846 putative GSH binding site (G-site) [chemical binding]; other site 511145009847 dimer interface [polypeptide binding]; other site 511145009848 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 511145009849 dimer interface [polypeptide binding]; other site 511145009850 N-terminal domain interface [polypeptide binding]; other site 511145009851 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 511145009852 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 511145009853 23S rRNA interface [nucleotide binding]; other site 511145009854 L3 interface [polypeptide binding]; other site 511145009855 Predicted ATPase [General function prediction only]; Region: COG1485 511145009856 hypothetical protein; Provisional; Region: PRK11677 511145009857 serine endoprotease; Provisional; Region: PRK10139 511145009858 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 511145009859 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511145009860 protein binding site [polypeptide binding]; other site 511145009861 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511145009862 serine endoprotease; Provisional; Region: PRK10898 511145009863 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 511145009864 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511145009865 protein binding site [polypeptide binding]; other site 511145009866 malate dehydrogenase; Provisional; Region: PRK05086 511145009867 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 511145009868 NAD binding site [chemical binding]; other site 511145009869 dimerization interface [polypeptide binding]; other site 511145009870 Substrate binding site [chemical binding]; other site 511145009871 arginine repressor; Provisional; Region: PRK05066 511145009872 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511145009873 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511145009874 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 511145009875 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 511145009876 RNAase interaction site [polypeptide binding]; other site 511145009877 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 511145009878 Fusaric acid resistance protein family; Region: FUSC; pfam04632 511145009879 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 511145009880 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145009881 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145009882 efflux system membrane protein; Provisional; Region: PRK11594 511145009883 transcriptional regulator; Provisional; Region: PRK10632 511145009884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145009885 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 511145009886 putative effector binding pocket; other site 511145009887 dimerization interface [polypeptide binding]; other site 511145009888 protease TldD; Provisional; Region: tldD; PRK10735 511145009889 hypothetical protein; Provisional; Region: PRK10899 511145009890 Protein of unknown function; Region: DUF3971; pfam13116 511145009891 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 511145009892 ribonuclease G; Provisional; Region: PRK11712 511145009893 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 511145009894 homodimer interface [polypeptide binding]; other site 511145009895 oligonucleotide binding site [chemical binding]; other site 511145009896 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 511145009897 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 511145009898 active site 511145009899 dimer interface [polypeptide binding]; other site 511145009900 rod shape-determining protein MreD; Provisional; Region: PRK11060 511145009901 rod shape-determining protein MreC; Region: mreC; TIGR00219 511145009902 rod shape-determining protein MreB; Provisional; Region: PRK13927 511145009903 MreB and similar proteins; Region: MreB_like; cd10225 511145009904 nucleotide binding site [chemical binding]; other site 511145009905 Mg binding site [ion binding]; other site 511145009906 putative protofilament interaction site [polypeptide binding]; other site 511145009907 RodZ interaction site [polypeptide binding]; other site 511145009908 regulatory protein CsrD; Provisional; Region: PRK11059 511145009909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511145009910 metal binding site [ion binding]; metal-binding site 511145009911 active site 511145009912 I-site; other site 511145009913 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145009914 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 511145009915 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 511145009916 NADP binding site [chemical binding]; other site 511145009917 dimer interface [polypeptide binding]; other site 511145009918 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 511145009919 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511145009920 carboxyltransferase (CT) interaction site; other site 511145009921 biotinylation site [posttranslational modification]; other site 511145009922 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 511145009923 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511145009924 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 511145009925 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 511145009926 hypothetical protein; Provisional; Region: PRK10633 511145009927 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 511145009928 Na binding site [ion binding]; other site 511145009929 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 511145009930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145009931 S-adenosylmethionine binding site [chemical binding]; other site 511145009932 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 511145009933 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 511145009934 FMN binding site [chemical binding]; other site 511145009935 active site 511145009936 catalytic residues [active] 511145009937 substrate binding site [chemical binding]; other site 511145009938 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 511145009939 putative methyltransferase; Provisional; Region: PRK11524 511145009940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145009941 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 511145009942 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 511145009943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145009944 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 511145009945 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 511145009946 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145009947 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145009948 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 511145009949 MMPL family; Region: MMPL; cl14618 511145009950 MMPL family; Region: MMPL; cl14618 511145009951 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 511145009952 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 511145009953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 511145009954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145009955 dimer interface [polypeptide binding]; other site 511145009956 conserved gate region; other site 511145009957 putative PBP binding loops; other site 511145009958 ABC-ATPase subunit interface; other site 511145009959 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 511145009960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145009961 dimer interface [polypeptide binding]; other site 511145009962 conserved gate region; other site 511145009963 putative PBP binding loops; other site 511145009964 ABC-ATPase subunit interface; other site 511145009965 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511145009966 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511145009967 Walker A/P-loop; other site 511145009968 ATP binding site [chemical binding]; other site 511145009969 Q-loop/lid; other site 511145009970 ABC transporter signature motif; other site 511145009971 Walker B; other site 511145009972 D-loop; other site 511145009973 H-loop/switch region; other site 511145009974 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 511145009975 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 511145009976 trimer interface [polypeptide binding]; other site 511145009977 putative metal binding site [ion binding]; other site 511145009978 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 511145009979 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 511145009980 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 511145009981 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 511145009982 shikimate binding site; other site 511145009983 NAD(P) binding site [chemical binding]; other site 511145009984 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 511145009985 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511145009986 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 511145009987 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511145009988 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511145009989 hypothetical protein; Validated; Region: PRK03430 511145009990 hypothetical protein; Provisional; Region: PRK10736 511145009991 DNA protecting protein DprA; Region: dprA; TIGR00732 511145009992 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 511145009993 active site 511145009994 catalytic residues [active] 511145009995 metal binding site [ion binding]; metal-binding site 511145009996 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 511145009997 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 511145009998 putative active site [active] 511145009999 substrate binding site [chemical binding]; other site 511145010000 putative cosubstrate binding site; other site 511145010001 catalytic site [active] 511145010002 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 511145010003 substrate binding site [chemical binding]; other site 511145010004 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 511145010005 putative RNA binding site [nucleotide binding]; other site 511145010006 16S rRNA methyltransferase B; Provisional; Region: PRK10901 511145010007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145010008 S-adenosylmethionine binding site [chemical binding]; other site 511145010009 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 511145010010 TrkA-N domain; Region: TrkA_N; pfam02254 511145010011 TrkA-C domain; Region: TrkA_C; pfam02080 511145010012 TrkA-N domain; Region: TrkA_N; pfam02254 511145010013 TrkA-C domain; Region: TrkA_C; pfam02080 511145010014 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 511145010015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 511145010016 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 511145010017 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 511145010018 DNA binding residues [nucleotide binding] 511145010019 dimer interface [polypeptide binding]; other site 511145010020 metal binding site [ion binding]; metal-binding site 511145010021 hypothetical protein; Provisional; Region: PRK10203 511145010022 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 511145010023 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 511145010024 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 511145010025 alphaNTD homodimer interface [polypeptide binding]; other site 511145010026 alphaNTD - beta interaction site [polypeptide binding]; other site 511145010027 alphaNTD - beta' interaction site [polypeptide binding]; other site 511145010028 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 511145010029 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 511145010030 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 511145010031 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511145010032 RNA binding surface [nucleotide binding]; other site 511145010033 30S ribosomal protein S11; Validated; Region: PRK05309 511145010034 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 511145010035 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 511145010036 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 511145010037 SecY translocase; Region: SecY; pfam00344 511145010038 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 511145010039 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 511145010040 23S rRNA binding site [nucleotide binding]; other site 511145010041 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 511145010042 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 511145010043 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 511145010044 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 511145010045 23S rRNA interface [nucleotide binding]; other site 511145010046 5S rRNA interface [nucleotide binding]; other site 511145010047 L27 interface [polypeptide binding]; other site 511145010048 L5 interface [polypeptide binding]; other site 511145010049 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 511145010050 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511145010051 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511145010052 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 511145010053 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 511145010054 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 511145010055 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 511145010056 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 511145010057 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 511145010058 RNA binding site [nucleotide binding]; other site 511145010059 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 511145010060 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 511145010061 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 511145010062 23S rRNA interface [nucleotide binding]; other site 511145010063 putative translocon interaction site; other site 511145010064 signal recognition particle (SRP54) interaction site; other site 511145010065 L23 interface [polypeptide binding]; other site 511145010066 trigger factor interaction site; other site 511145010067 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 511145010068 23S rRNA interface [nucleotide binding]; other site 511145010069 5S rRNA interface [nucleotide binding]; other site 511145010070 putative antibiotic binding site [chemical binding]; other site 511145010071 L25 interface [polypeptide binding]; other site 511145010072 L27 interface [polypeptide binding]; other site 511145010073 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 511145010074 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 511145010075 G-X-X-G motif; other site 511145010076 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 511145010077 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 511145010078 protein-rRNA interface [nucleotide binding]; other site 511145010079 putative translocon binding site; other site 511145010080 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 511145010081 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 511145010082 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 511145010083 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 511145010084 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 511145010085 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 511145010086 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 511145010087 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 511145010088 protein secretion protein GspB; Provisional; Region: PRK09697 511145010089 AAA domain; Region: AAA_22; pfam13401 511145010090 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 511145010091 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 511145010092 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 511145010093 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 511145010094 type II secretion system protein D; Region: type_II_gspD; TIGR02517 511145010095 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 511145010096 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 511145010097 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 511145010098 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 511145010099 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 511145010100 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 511145010101 Walker A motif; other site 511145010102 ATP binding site [chemical binding]; other site 511145010103 Walker B motif; other site 511145010104 type II secretion system protein F; Region: GspF; TIGR02120 511145010105 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511145010106 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511145010107 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 511145010108 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 511145010109 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 511145010110 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 511145010111 Type II transport protein GspH; Region: GspH; pfam12019 511145010112 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 511145010113 type II secretion system protein I; Region: gspI; TIGR01707 511145010114 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 511145010115 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 511145010116 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 511145010117 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 511145010118 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 511145010119 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 511145010120 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 511145010121 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 511145010122 GspL periplasmic domain; Region: GspL_C; pfam12693 511145010123 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 511145010124 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 511145010125 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 511145010126 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 511145010127 Ferritin-like domain; Region: Ferritin; pfam00210 511145010128 heme binding site [chemical binding]; other site 511145010129 ferroxidase pore; other site 511145010130 ferroxidase diiron center [ion binding]; other site 511145010131 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 511145010132 Chitin-binding domain type 3; Region: ChtBD3; smart00495 511145010133 Chitin-binding domain type 3; Region: ChtBD3; smart00495 511145010134 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 511145010135 aromatic chitin/cellulose binding site residues [chemical binding]; other site 511145010136 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 511145010137 active site 511145010138 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 511145010139 elongation factor Tu; Reviewed; Region: PRK00049 511145010140 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511145010141 G1 box; other site 511145010142 GEF interaction site [polypeptide binding]; other site 511145010143 GTP/Mg2+ binding site [chemical binding]; other site 511145010144 Switch I region; other site 511145010145 G2 box; other site 511145010146 G3 box; other site 511145010147 Switch II region; other site 511145010148 G4 box; other site 511145010149 G5 box; other site 511145010150 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511145010151 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511145010152 Antibiotic Binding Site [chemical binding]; other site 511145010153 elongation factor G; Reviewed; Region: PRK00007 511145010154 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 511145010155 G1 box; other site 511145010156 putative GEF interaction site [polypeptide binding]; other site 511145010157 GTP/Mg2+ binding site [chemical binding]; other site 511145010158 Switch I region; other site 511145010159 G2 box; other site 511145010160 G3 box; other site 511145010161 Switch II region; other site 511145010162 G4 box; other site 511145010163 G5 box; other site 511145010164 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 511145010165 Elongation Factor G, domain II; Region: EFG_II; pfam14492 511145010166 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 511145010167 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 511145010168 30S ribosomal protein S7; Validated; Region: PRK05302 511145010169 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 511145010170 S17 interaction site [polypeptide binding]; other site 511145010171 S8 interaction site; other site 511145010172 16S rRNA interaction site [nucleotide binding]; other site 511145010173 streptomycin interaction site [chemical binding]; other site 511145010174 23S rRNA interaction site [nucleotide binding]; other site 511145010175 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 511145010176 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 511145010177 sulfur relay protein TusC; Validated; Region: PRK00211 511145010178 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 511145010179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 511145010180 YheO-like PAS domain; Region: PAS_6; pfam08348 511145010181 HTH domain; Region: HTH_22; pfam13309 511145010182 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 511145010183 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 511145010184 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 511145010185 phi X174 lysis protein; Provisional; Region: PRK02793 511145010186 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 511145010187 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 511145010188 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 511145010189 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 511145010190 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 511145010191 TrkA-N domain; Region: TrkA_N; pfam02254 511145010192 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 511145010193 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 511145010194 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511145010195 ABC transporter; Region: ABC_tran_2; pfam12848 511145010196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511145010197 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 511145010198 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 511145010199 putative hydrolase; Provisional; Region: PRK10985 511145010200 hypothetical protein; Provisional; Region: PRK04966 511145010201 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 511145010202 active site 511145010203 hypothetical protein; Provisional; Region: PRK10738 511145010204 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 511145010205 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 511145010206 ligand binding site [chemical binding]; other site 511145010207 flexible hinge region; other site 511145010208 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 511145010209 putative switch regulator; other site 511145010210 non-specific DNA interactions [nucleotide binding]; other site 511145010211 DNA binding site [nucleotide binding] 511145010212 sequence specific DNA binding site [nucleotide binding]; other site 511145010213 putative cAMP binding site [chemical binding]; other site 511145010214 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 511145010215 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 511145010216 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 511145010217 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 511145010218 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511145010219 inhibitor-cofactor binding pocket; inhibition site 511145010220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145010221 catalytic residue [active] 511145010222 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 511145010223 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 511145010224 glutamine binding [chemical binding]; other site 511145010225 catalytic triad [active] 511145010226 cell filamentation protein Fic; Provisional; Region: PRK10347 511145010227 Protein of unknown function (DUF2559); Region: DUF2559; pfam10832 511145010228 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 511145010229 substrate binding site [chemical binding]; other site 511145010230 putative transporter; Provisional; Region: PRK03699 511145010231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145010232 putative substrate translocation pore; other site 511145010233 nitrite reductase subunit NirD; Provisional; Region: PRK14989 511145010234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145010235 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 511145010236 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 511145010237 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 511145010238 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 511145010239 nitrite transporter NirC; Provisional; Region: PRK11562 511145010240 siroheme synthase; Provisional; Region: cysG; PRK10637 511145010241 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 511145010242 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 511145010243 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 511145010244 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 511145010245 active site 511145010246 SAM binding site [chemical binding]; other site 511145010247 homodimer interface [polypeptide binding]; other site 511145010248 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 511145010249 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 511145010250 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145010251 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 511145010252 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 511145010253 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511145010254 dimer interface [polypeptide binding]; other site 511145010255 active site 511145010256 fructoselysine 3-epimerase; Provisional; Region: PRK09856 511145010257 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 511145010258 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 511145010259 substrate binding site [chemical binding]; other site 511145010260 ATP binding site [chemical binding]; other site 511145010261 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 511145010262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145010263 DNA-binding site [nucleotide binding]; DNA binding site 511145010264 UTRA domain; Region: UTRA; pfam07702 511145010265 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 511145010266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511145010267 catalytic residue [active] 511145010268 Protein of unknown function; Region: YhfT; pfam10797 511145010269 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 511145010270 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 511145010271 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 511145010272 active site 511145010273 substrate binding pocket [chemical binding]; other site 511145010274 homodimer interaction site [polypeptide binding]; other site 511145010275 putative mutase; Provisional; Region: PRK12383 511145010276 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 511145010277 dimer interface [polypeptide binding]; other site 511145010278 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 511145010279 active site 511145010280 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511145010281 substrate binding site [chemical binding]; other site 511145010282 catalytic residue [active] 511145010283 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 511145010284 Helix-turn-helix domain; Region: HTH_41; pfam14502 511145010285 YhfZ C-terminal domain; Region: YhfZ_C; pfam14503 511145010286 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 511145010287 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 511145010288 active site 511145010289 HIGH motif; other site 511145010290 dimer interface [polypeptide binding]; other site 511145010291 KMSKS motif; other site 511145010292 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 511145010293 phosphoglycolate phosphatase; Provisional; Region: PRK13222 511145010294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145010295 motif II; other site 511145010296 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 511145010297 substrate binding site [chemical binding]; other site 511145010298 hexamer interface [polypeptide binding]; other site 511145010299 metal binding site [ion binding]; metal-binding site 511145010300 DNA adenine methylase; Provisional; Region: PRK10904 511145010301 cell division protein DamX; Validated; Region: PRK10905 511145010302 Sporulation related domain; Region: SPOR; pfam05036 511145010303 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 511145010304 active site 511145010305 dimer interface [polypeptide binding]; other site 511145010306 metal binding site [ion binding]; metal-binding site 511145010307 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 511145010308 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 511145010309 ADP binding site [chemical binding]; other site 511145010310 magnesium binding site [ion binding]; other site 511145010311 putative shikimate binding site; other site 511145010312 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 511145010313 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 511145010314 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 511145010315 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 511145010316 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 511145010317 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 511145010318 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 511145010319 Transglycosylase; Region: Transgly; pfam00912 511145010320 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 511145010321 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 511145010322 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511145010323 ADP-ribose binding site [chemical binding]; other site 511145010324 dimer interface [polypeptide binding]; other site 511145010325 active site 511145010326 nudix motif; other site 511145010327 metal binding site [ion binding]; metal-binding site 511145010328 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 511145010329 GMP/IMP nucleotidase; Provisional; Region: PRK14988 511145010330 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 511145010331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145010332 motif II; other site 511145010333 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511145010334 RNA binding surface [nucleotide binding]; other site 511145010335 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 511145010336 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 511145010337 dimerization interface [polypeptide binding]; other site 511145010338 domain crossover interface; other site 511145010339 redox-dependent activation switch; other site 511145010340 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 511145010341 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 511145010342 active site 511145010343 substrate-binding site [chemical binding]; other site 511145010344 metal-binding site [ion binding] 511145010345 ATP binding site [chemical binding]; other site 511145010346 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 511145010347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145010348 dimerization interface [polypeptide binding]; other site 511145010349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145010350 dimer interface [polypeptide binding]; other site 511145010351 phosphorylation site [posttranslational modification] 511145010352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145010353 ATP binding site [chemical binding]; other site 511145010354 Mg2+ binding site [ion binding]; other site 511145010355 G-X-G motif; other site 511145010356 osmolarity response regulator; Provisional; Region: ompR; PRK09468 511145010357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145010358 active site 511145010359 phosphorylation site [posttranslational modification] 511145010360 intermolecular recognition site; other site 511145010361 dimerization interface [polypeptide binding]; other site 511145010362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145010363 DNA binding site [nucleotide binding] 511145010364 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 511145010365 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511145010366 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511145010367 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 511145010368 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 511145010369 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 511145010370 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 511145010371 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 511145010372 RNA binding site [nucleotide binding]; other site 511145010373 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 511145010374 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 511145010375 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 511145010376 G1 box; other site 511145010377 GTP/Mg2+ binding site [chemical binding]; other site 511145010378 Switch I region; other site 511145010379 G2 box; other site 511145010380 G3 box; other site 511145010381 Switch II region; other site 511145010382 G4 box; other site 511145010383 G5 box; other site 511145010384 Nucleoside recognition; Region: Gate; pfam07670 511145010385 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 511145010386 Nucleoside recognition; Region: Gate; pfam07670 511145010387 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 511145010388 putative transposase; Provisional; Region: PRK09857 511145010389 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 511145010390 carboxylesterase BioH; Provisional; Region: PRK10349 511145010391 Putative lysophospholipase; Region: Hydrolase_4; cl19140 511145010392 Putative lysophospholipase; Region: Hydrolase_4; cl19140 511145010393 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 511145010394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511145010395 active site 511145010396 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 511145010397 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 511145010398 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 511145010399 high-affinity gluconate transporter; Provisional; Region: PRK14984 511145010400 GntP family permease; Region: GntP_permease; pfam02447 511145010401 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 511145010402 4-alpha-glucanotransferase; Region: malQ; TIGR00217 511145010403 maltodextrin phosphorylase; Provisional; Region: PRK14985 511145010404 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 511145010405 homodimer interface [polypeptide binding]; other site 511145010406 active site pocket [active] 511145010407 transcriptional regulator MalT; Provisional; Region: PRK04841 511145010408 AAA ATPase domain; Region: AAA_16; pfam13191 511145010409 Cohesin loading factor; Region: Cohesin_load; pfam10345 511145010410 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145010411 DNA binding residues [nucleotide binding] 511145010412 dimerization interface [polypeptide binding]; other site 511145010413 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 511145010414 RNA 3' phosphate cyclase domain - RNA phosphate cyclases are enzymes that catalyze the ATP-dependent conversion of 3'-phosphate at the end of RNA into 2', 3'-cyclic phosphodiester bond. The enzymes are conserved in eucaryotes; Region: RNA_Cyclase; cd00295 511145010415 putative active site [active] 511145010416 adenylation catalytic residue [active] 511145010417 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 511145010418 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 511145010419 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 511145010420 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 511145010421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145010422 Walker A motif; other site 511145010423 ATP binding site [chemical binding]; other site 511145010424 Walker B motif; other site 511145010425 arginine finger; other site 511145010426 intramembrane serine protease GlpG; Provisional; Region: PRK10907 511145010427 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 511145010428 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 511145010429 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 511145010430 active site residue [active] 511145010431 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 511145010432 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 511145010433 glycogen phosphorylase; Provisional; Region: PRK14986 511145010434 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 511145010435 homodimer interface [polypeptide binding]; other site 511145010436 active site pocket [active] 511145010437 glycogen synthase; Provisional; Region: glgA; PRK00654 511145010438 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 511145010439 ADP-binding pocket [chemical binding]; other site 511145010440 homodimer interface [polypeptide binding]; other site 511145010441 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 511145010442 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 511145010443 ligand binding site; other site 511145010444 oligomer interface; other site 511145010445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511145010446 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 511145010447 dimer interface [polypeptide binding]; other site 511145010448 N-terminal domain interface [polypeptide binding]; other site 511145010449 sulfate 1 binding site; other site 511145010450 glycogen debranching enzyme; Provisional; Region: PRK03705 511145010451 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 511145010452 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 511145010453 active site 511145010454 catalytic site [active] 511145010455 glycogen branching enzyme; Provisional; Region: PRK05402 511145010456 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 511145010457 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 511145010458 active site 511145010459 catalytic site [active] 511145010460 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 511145010461 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 511145010462 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 511145010463 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 511145010464 putative antibiotic transporter; Provisional; Region: PRK10739 511145010465 low affinity gluconate transporter; Provisional; Region: PRK10472 511145010466 GntP family permease; Region: GntP_permease; pfam02447 511145010467 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 511145010468 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 511145010469 ATP-binding site [chemical binding]; other site 511145010470 Gluconate-6-phosphate binding site [chemical binding]; other site 511145010471 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 511145010472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145010473 DNA binding site [nucleotide binding] 511145010474 domain linker motif; other site 511145010475 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 511145010476 putative ligand binding site [chemical binding]; other site 511145010477 putative dimerization interface [polypeptide binding]; other site 511145010478 Pirin-related protein [General function prediction only]; Region: COG1741 511145010479 Pirin; Region: Pirin; pfam02678 511145010480 putative oxidoreductase; Provisional; Region: PRK10206 511145010481 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 511145010482 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 511145010483 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511145010484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145010485 Coenzyme A binding pocket [chemical binding]; other site 511145010486 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 511145010487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 511145010488 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 511145010489 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 511145010490 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 511145010491 Immunity protein 19; Region: Imm19; pfam15567 511145010492 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 511145010493 hypothetical protein; Provisional; Region: PRK10350 511145010494 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 511145010495 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 511145010496 putative active site [active] 511145010497 catalytic site [active] 511145010498 putative metal binding site [ion binding]; other site 511145010499 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 511145010500 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 511145010501 Walker A/P-loop; other site 511145010502 ATP binding site [chemical binding]; other site 511145010503 Q-loop/lid; other site 511145010504 ABC transporter signature motif; other site 511145010505 Walker B; other site 511145010506 D-loop; other site 511145010507 H-loop/switch region; other site 511145010508 TOBE domain; Region: TOBE_2; pfam08402 511145010509 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511145010510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145010511 dimer interface [polypeptide binding]; other site 511145010512 conserved gate region; other site 511145010513 putative PBP binding loops; other site 511145010514 ABC-ATPase subunit interface; other site 511145010515 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 511145010516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145010517 dimer interface [polypeptide binding]; other site 511145010518 conserved gate region; other site 511145010519 putative PBP binding loops; other site 511145010520 ABC-ATPase subunit interface; other site 511145010521 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 511145010522 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511145010523 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 511145010524 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 511145010525 Walker A/P-loop; other site 511145010526 ATP binding site [chemical binding]; other site 511145010527 Q-loop/lid; other site 511145010528 ABC transporter signature motif; other site 511145010529 Walker B; other site 511145010530 D-loop; other site 511145010531 H-loop/switch region; other site 511145010532 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 511145010533 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 511145010534 Walker A/P-loop; other site 511145010535 ATP binding site [chemical binding]; other site 511145010536 Q-loop/lid; other site 511145010537 ABC transporter signature motif; other site 511145010538 Walker B; other site 511145010539 D-loop; other site 511145010540 H-loop/switch region; other site 511145010541 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 511145010542 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 511145010543 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 511145010544 TM-ABC transporter signature motif; other site 511145010545 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 511145010546 TM-ABC transporter signature motif; other site 511145010547 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 511145010548 dimerization interface [polypeptide binding]; other site 511145010549 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 511145010550 ligand binding site [chemical binding]; other site 511145010551 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 511145010552 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 511145010553 dimerization interface [polypeptide binding]; other site 511145010554 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 511145010555 ligand binding site [chemical binding]; other site 511145010556 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 511145010557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511145010558 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511145010559 DNA binding residues [nucleotide binding] 511145010560 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 511145010561 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 511145010562 cell division protein FtsE; Provisional; Region: PRK10908 511145010563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145010564 Walker A/P-loop; other site 511145010565 ATP binding site [chemical binding]; other site 511145010566 Q-loop/lid; other site 511145010567 ABC transporter signature motif; other site 511145010568 Walker B; other site 511145010569 D-loop; other site 511145010570 H-loop/switch region; other site 511145010571 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 511145010572 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 511145010573 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 511145010574 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511145010575 P loop; other site 511145010576 GTP binding site [chemical binding]; other site 511145010577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145010578 S-adenosylmethionine binding site [chemical binding]; other site 511145010579 hypothetical protein; Provisional; Region: PRK10910 511145010580 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 511145010581 Predicted membrane protein [Function unknown]; Region: COG3714 511145010582 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 511145010583 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 511145010584 metal-binding site [ion binding] 511145010585 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511145010586 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511145010587 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 511145010588 CPxP motif; other site 511145010589 hypothetical protein; Provisional; Region: PRK11212 511145010590 hypothetical protein; Provisional; Region: PRK11615 511145010591 major facilitator superfamily transporter; Provisional; Region: PRK05122 511145010592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145010593 putative substrate translocation pore; other site 511145010594 Domain of unknown function DUF20; Region: UPF0118; cl00465 511145010595 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 511145010596 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 511145010597 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 511145010598 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 511145010599 substrate binding site [chemical binding]; other site 511145010600 nickel transporter permease NikB; Provisional; Region: PRK10352 511145010601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145010602 dimer interface [polypeptide binding]; other site 511145010603 conserved gate region; other site 511145010604 putative PBP binding loops; other site 511145010605 ABC-ATPase subunit interface; other site 511145010606 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 511145010607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145010608 dimer interface [polypeptide binding]; other site 511145010609 conserved gate region; other site 511145010610 putative PBP binding loops; other site 511145010611 ABC-ATPase subunit interface; other site 511145010612 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 511145010613 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145010614 Walker A/P-loop; other site 511145010615 ATP binding site [chemical binding]; other site 511145010616 Q-loop/lid; other site 511145010617 ABC transporter signature motif; other site 511145010618 Walker B; other site 511145010619 D-loop; other site 511145010620 H-loop/switch region; other site 511145010621 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511145010622 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 511145010623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145010624 Walker A/P-loop; other site 511145010625 ATP binding site [chemical binding]; other site 511145010626 Q-loop/lid; other site 511145010627 ABC transporter signature motif; other site 511145010628 Walker B; other site 511145010629 D-loop; other site 511145010630 H-loop/switch region; other site 511145010631 nickel responsive regulator; Provisional; Region: PRK02967 511145010632 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 511145010633 PAAR motif; Region: PAAR_motif; cl15808 511145010634 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 511145010635 RHS Repeat; Region: RHS_repeat; pfam05593 511145010636 RHS Repeat; Region: RHS_repeat; pfam05593 511145010637 RHS Repeat; Region: RHS_repeat; pfam05593 511145010638 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 511145010639 RHS Repeat; Region: RHS_repeat; pfam05593 511145010640 RHS Repeat; Region: RHS_repeat; pfam05593 511145010641 RHS protein; Region: RHS; pfam03527 511145010642 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 511145010643 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 511145010644 NTF2 fold immunity protein; Region: Imm-NTF2-2; pfam15631 511145010645 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 511145010646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511145010647 Transposase [DNA replication, recombination, and repair]; Region: COG5433 511145010648 Transposase [DNA replication, recombination, and repair]; Region: COG5433 511145010649 Structural glycoprotein p40/gp41 conserved region; Region: Baculo_gp41; pfam04700 511145010650 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 511145010651 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 511145010652 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511145010653 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 511145010654 Walker A/P-loop; other site 511145010655 ATP binding site [chemical binding]; other site 511145010656 Q-loop/lid; other site 511145010657 ABC transporter signature motif; other site 511145010658 Walker B; other site 511145010659 D-loop; other site 511145010660 H-loop/switch region; other site 511145010661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145010662 Walker A/P-loop; other site 511145010663 ATP binding site [chemical binding]; other site 511145010664 Q-loop/lid; other site 511145010665 ABC transporter signature motif; other site 511145010666 Walker B; other site 511145010667 D-loop; other site 511145010668 H-loop/switch region; other site 511145010669 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 511145010670 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 511145010671 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 511145010672 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145010673 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145010674 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 511145010675 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 511145010676 Predicted flavoproteins [General function prediction only]; Region: COG2081 511145010677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145010678 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 511145010679 universal stress protein UspB; Provisional; Region: PRK04960 511145010680 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511145010681 Ligand Binding Site [chemical binding]; other site 511145010682 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 511145010683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145010684 putative substrate translocation pore; other site 511145010685 putative methyltransferase; Provisional; Region: PRK10742 511145010686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145010687 S-adenosylmethionine binding site [chemical binding]; other site 511145010688 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 511145010689 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 511145010690 active site 511145010691 Zn binding site [ion binding]; other site 511145010692 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 511145010693 glutathione reductase; Validated; Region: PRK06116 511145010694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145010695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145010696 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 511145010697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511145010698 dimerization interface [polypeptide binding]; other site 511145010699 putative DNA binding site [nucleotide binding]; other site 511145010700 putative Zn2+ binding site [ion binding]; other site 511145010701 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 511145010702 Citrate transporter; Region: CitMHS; pfam03600 511145010703 transmembrane helices; other site 511145010704 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 511145010705 catalytic residues [active] 511145010706 Transposase domain (DUF772); Region: DUF772; pfam05598 511145010707 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 511145010708 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 511145010709 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511145010710 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 511145010711 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 511145010712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145010713 DNA binding residues [nucleotide binding] 511145010714 dimerization interface [polypeptide binding]; other site 511145010715 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 511145010716 MgtC family; Region: MgtC; pfam02308 511145010717 acid-resistance protein; Provisional; Region: hdeB; PRK11566 511145010718 acid-resistance protein; Provisional; Region: PRK10208 511145010719 acid-resistance membrane protein; Provisional; Region: PRK10209 511145010720 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 511145010721 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 511145010722 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145010723 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145010724 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 511145010725 MMPL family; Region: MMPL; cl14618 511145010726 MMPL family; Region: MMPL; cl14618 511145010727 transcriptional regulator YdeO; Provisional; Region: PRK09940 511145010728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145010729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145010730 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 511145010731 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145010732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145010733 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 511145010734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145010735 catalytic residue [active] 511145010736 Haem-binding domain; Region: Haem_bd; pfam14376 511145010737 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 511145010738 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 511145010739 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 511145010740 trehalase; Provisional; Region: treF; PRK13270 511145010741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 511145010742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145010743 DNA binding residues [nucleotide binding] 511145010744 dimerization interface [polypeptide binding]; other site 511145010745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145010746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145010747 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 511145010748 putative effector binding pocket; other site 511145010749 putative dimerization interface [polypeptide binding]; other site 511145010750 inner membrane protein YhjD; Region: TIGR00766 511145010751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145010752 metabolite-proton symporter; Region: 2A0106; TIGR00883 511145010753 putative substrate translocation pore; other site 511145010754 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 511145010755 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 511145010756 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145010757 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 511145010758 substrate binding site [chemical binding]; other site 511145010759 ATP binding site [chemical binding]; other site 511145010760 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511145010761 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511145010762 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 511145010763 putative diguanylate cyclase; Provisional; Region: PRK13561 511145010764 HAMP domain; Region: HAMP; pfam00672 511145010765 diguanylate cyclase; Region: GGDEF; smart00267 511145010766 metal binding site [ion binding]; metal-binding site 511145010767 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145010768 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 511145010769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145010770 binding surface 511145010771 TPR motif; other site 511145010772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145010773 binding surface 511145010774 TPR motif; other site 511145010775 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 511145010776 endo-1,4-D-glucanase; Provisional; Region: PRK11097 511145010777 cellulose synthase regulator protein; Provisional; Region: PRK11114 511145010778 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 511145010779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511145010780 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 511145010781 DXD motif; other site 511145010782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511145010783 PilZ domain; Region: PilZ; pfam07238 511145010784 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 511145010785 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 511145010786 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 511145010787 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 511145010788 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 511145010789 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 511145010790 serine transporter; Region: stp; TIGR00814 511145010791 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 511145010792 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145010793 Walker A/P-loop; other site 511145010794 ATP binding site [chemical binding]; other site 511145010795 Q-loop/lid; other site 511145010796 ABC transporter signature motif; other site 511145010797 Walker B; other site 511145010798 D-loop; other site 511145010799 H-loop/switch region; other site 511145010800 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511145010801 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 511145010802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145010803 Walker A/P-loop; other site 511145010804 ATP binding site [chemical binding]; other site 511145010805 Q-loop/lid; other site 511145010806 ABC transporter signature motif; other site 511145010807 Walker B; other site 511145010808 D-loop; other site 511145010809 H-loop/switch region; other site 511145010810 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511145010811 dipeptide transporter; Provisional; Region: PRK10913 511145010812 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 511145010813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145010814 dimer interface [polypeptide binding]; other site 511145010815 conserved gate region; other site 511145010816 putative PBP binding loops; other site 511145010817 ABC-ATPase subunit interface; other site 511145010818 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511145010819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145010820 dimer interface [polypeptide binding]; other site 511145010821 conserved gate region; other site 511145010822 putative PBP binding loops; other site 511145010823 ABC-ATPase subunit interface; other site 511145010824 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 511145010825 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 511145010826 peptide binding site [polypeptide binding]; other site 511145010827 phosphoethanolamine transferase; Provisional; Region: PRK11560 511145010828 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 511145010829 Sulfatase; Region: Sulfatase; pfam00884 511145010830 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 511145010831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145010832 putative substrate translocation pore; other site 511145010833 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 511145010834 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 511145010835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511145010836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145010837 Coenzyme A binding pocket [chemical binding]; other site 511145010838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 511145010839 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 511145010840 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 511145010841 molybdopterin cofactor binding site [chemical binding]; other site 511145010842 substrate binding site [chemical binding]; other site 511145010843 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 511145010844 molybdopterin cofactor binding site; other site 511145010845 putative outer membrane lipoprotein; Provisional; Region: PRK10510 511145010846 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 511145010847 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 511145010848 ligand binding site [chemical binding]; other site 511145010849 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 511145010850 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 511145010851 dimerization interface [polypeptide binding]; other site 511145010852 ligand binding site [chemical binding]; other site 511145010853 NADP binding site [chemical binding]; other site 511145010854 catalytic site [active] 511145010855 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 511145010856 Predicted transcriptional regulator [Transcription]; Region: COG2944 511145010857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145010858 non-specific DNA binding site [nucleotide binding]; other site 511145010859 salt bridge; other site 511145010860 sequence-specific DNA binding site [nucleotide binding]; other site 511145010861 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511145010862 DNA-binding site [nucleotide binding]; DNA binding site 511145010863 RNA-binding motif; other site 511145010864 small toxic polypeptide; Provisional; Region: PRK09759 511145010865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145010866 Helix-turn-helix domain; Region: HTH_28; pfam13518 511145010867 Helix-turn-helix domain; Region: HTH_28; pfam13518 511145010868 putative transposase OrfB; Reviewed; Region: PHA02517 511145010869 HTH-like domain; Region: HTH_21; pfam13276 511145010870 Integrase core domain; Region: rve; pfam00665 511145010871 Integrase core domain; Region: rve_2; pfam13333 511145010872 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 511145010873 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 511145010874 DALR anticodon binding domain; Region: DALR_1; pfam05746 511145010875 anticodon binding site; other site 511145010876 tRNA binding surface [nucleotide binding]; other site 511145010877 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 511145010878 dimer interface [polypeptide binding]; other site 511145010879 motif 1; other site 511145010880 active site 511145010881 motif 2; other site 511145010882 motif 3; other site 511145010883 YsaB-like lipoprotein; Region: YsaB; pfam13983 511145010884 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 511145010885 hypothetical protein; Provisional; Region: PRK11383 511145010886 yiaA/B two helix domain; Region: YiaAB; pfam05360 511145010887 yiaA/B two helix domain; Region: YiaAB; pfam05360 511145010888 hypothetical protein; Provisional; Region: PRK11403 511145010889 yiaA/B two helix domain; Region: YiaAB; pfam05360 511145010890 xylulokinase; Provisional; Region: PRK15027 511145010891 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 511145010892 N- and C-terminal domain interface [polypeptide binding]; other site 511145010893 active site 511145010894 MgATP binding site [chemical binding]; other site 511145010895 catalytic site [active] 511145010896 metal binding site [ion binding]; metal-binding site 511145010897 xylulose binding site [chemical binding]; other site 511145010898 homodimer interface [polypeptide binding]; other site 511145010899 xylose isomerase; Provisional; Region: PRK05474 511145010900 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 511145010901 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 511145010902 putative ligand binding site [chemical binding]; other site 511145010903 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 511145010904 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511145010905 Walker A/P-loop; other site 511145010906 ATP binding site [chemical binding]; other site 511145010907 Q-loop/lid; other site 511145010908 ABC transporter signature motif; other site 511145010909 Walker B; other site 511145010910 D-loop; other site 511145010911 H-loop/switch region; other site 511145010912 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511145010913 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145010914 TM-ABC transporter signature motif; other site 511145010915 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 511145010916 putative dimerization interface [polypeptide binding]; other site 511145010917 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511145010918 putative ligand binding site [chemical binding]; other site 511145010919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145010920 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511145010921 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145010922 hypothetical protein; Provisional; Region: PRK10356 511145010923 Lysozyme subfamily 2; Region: LYZ2; smart00047 511145010924 alpha-amylase; Reviewed; Region: malS; PRK09505 511145010925 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 511145010926 active site 511145010927 catalytic site [active] 511145010928 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 511145010929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145010930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145010931 homodimer interface [polypeptide binding]; other site 511145010932 catalytic residue [active] 511145010933 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 511145010934 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145010935 Transcriptional regulator [Transcription]; Region: IclR; COG1414 511145010936 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 511145010937 Bacterial transcriptional regulator; Region: IclR; pfam01614 511145010938 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 511145010939 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 511145010940 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 511145010941 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 511145010942 DctM-like transporters; Region: DctM; pfam06808 511145010943 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 511145010944 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 511145010945 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 511145010946 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 511145010947 putative N- and C-terminal domain interface [polypeptide binding]; other site 511145010948 putative active site [active] 511145010949 MgATP binding site [chemical binding]; other site 511145010950 catalytic site [active] 511145010951 metal binding site [ion binding]; metal-binding site 511145010952 putative xylulose binding site [chemical binding]; other site 511145010953 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 511145010954 active site 511145010955 dimer interface [polypeptide binding]; other site 511145010956 magnesium binding site [ion binding]; other site 511145010957 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 511145010958 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 511145010959 AP (apurinic/apyrimidinic) site pocket; other site 511145010960 DNA interaction; other site 511145010961 Metal-binding active site; metal-binding site 511145010962 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 511145010963 intersubunit interface [polypeptide binding]; other site 511145010964 active site 511145010965 Zn2+ binding site [ion binding]; other site 511145010966 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 511145010967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511145010968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145010969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145010970 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 511145010971 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145010972 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145010973 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 511145010974 FlxA-like protein; Region: FlxA; pfam14282 511145010975 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 511145010976 NAD(P) binding site [chemical binding]; other site 511145010977 catalytic residues [active] 511145010978 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 511145010979 dimer interface [polypeptide binding]; other site 511145010980 active site 511145010981 metal binding site [ion binding]; metal-binding site 511145010982 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 511145010983 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 511145010984 G1 box; other site 511145010985 putative GEF interaction site [polypeptide binding]; other site 511145010986 GTP/Mg2+ binding site [chemical binding]; other site 511145010987 Switch I region; other site 511145010988 G2 box; other site 511145010989 G3 box; other site 511145010990 Switch II region; other site 511145010991 G4 box; other site 511145010992 G5 box; other site 511145010993 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 511145010994 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 511145010995 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 511145010996 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 511145010997 selenocysteine synthase; Provisional; Region: PRK04311 511145010998 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 511145010999 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 511145011000 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511145011001 catalytic residue [active] 511145011002 putative glutathione S-transferase; Provisional; Region: PRK10357 511145011003 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 511145011004 putative C-terminal domain interface [polypeptide binding]; other site 511145011005 putative GSH binding site (G-site) [chemical binding]; other site 511145011006 putative dimer interface [polypeptide binding]; other site 511145011007 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 511145011008 dimer interface [polypeptide binding]; other site 511145011009 N-terminal domain interface [polypeptide binding]; other site 511145011010 putative substrate binding pocket (H-site) [chemical binding]; other site 511145011011 PAAR motif; Region: PAAR_motif; cl15808 511145011012 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 511145011013 RHS Repeat; Region: RHS_repeat; pfam05593 511145011014 RHS Repeat; Region: RHS_repeat; pfam05593 511145011015 RHS Repeat; Region: RHS_repeat; pfam05593 511145011016 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 511145011017 RHS Repeat; Region: RHS_repeat; pfam05593 511145011018 RHS Repeat; Region: RHS_repeat; pfam05593 511145011019 RHS protein; Region: RHS; pfam03527 511145011020 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 511145011021 Putative toxin 55; Region: Toxin_55; pfam15606 511145011022 putative lyase; Provisional; Region: PRK09687 511145011023 HEAT-like repeat; Region: HEAT_EZ; pfam13513 511145011024 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 511145011025 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 511145011026 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145011027 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145011028 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 511145011029 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 511145011030 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 511145011031 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 511145011032 active site 511145011033 P-loop; other site 511145011034 phosphorylation site [posttranslational modification] 511145011035 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145011036 active site 511145011037 phosphorylation site [posttranslational modification] 511145011038 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 511145011039 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 511145011040 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 511145011041 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 511145011042 hypothetical protein; Provisional; Region: PRK11020 511145011043 L-lactate permease; Provisional; Region: PRK10420 511145011044 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 511145011045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145011046 DNA-binding site [nucleotide binding]; DNA binding site 511145011047 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 511145011048 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 511145011049 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 511145011050 active site 511145011051 substrate binding site [chemical binding]; other site 511145011052 FMN binding site [chemical binding]; other site 511145011053 putative catalytic residues [active] 511145011054 putative rRNA methylase; Provisional; Region: PRK10358 511145011055 serine acetyltransferase; Provisional; Region: cysE; PRK11132 511145011056 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 511145011057 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 511145011058 trimer interface [polypeptide binding]; other site 511145011059 active site 511145011060 substrate binding site [chemical binding]; other site 511145011061 CoA binding site [chemical binding]; other site 511145011062 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 511145011063 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 511145011064 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 511145011065 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 511145011066 SecA binding site; other site 511145011067 Preprotein binding site; other site 511145011068 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 511145011069 GSH binding site [chemical binding]; other site 511145011070 catalytic residues [active] 511145011071 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511145011072 active site residue [active] 511145011073 phosphoglyceromutase; Provisional; Region: PRK05434 511145011074 AmiB activator; Provisional; Region: PRK11637 511145011075 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 511145011076 HemX; Region: HemX; cl19375 511145011077 Peptidase family M23; Region: Peptidase_M23; pfam01551 511145011078 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 511145011079 NodB motif; other site 511145011080 putative active site [active] 511145011081 putative catalytic site [active] 511145011082 Zn binding site [ion binding]; other site 511145011083 putative glycosyl transferase; Provisional; Region: PRK10073 511145011084 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 511145011085 active site 511145011086 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 511145011087 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 511145011088 NAD(P) binding site [chemical binding]; other site 511145011089 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 511145011090 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 511145011091 substrate-cofactor binding pocket; other site 511145011092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145011093 catalytic residue [active] 511145011094 hypothetical protein; Provisional; Region: PRK11346 511145011095 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 511145011096 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 511145011097 NADP binding site [chemical binding]; other site 511145011098 homopentamer interface [polypeptide binding]; other site 511145011099 substrate binding site [chemical binding]; other site 511145011100 active site 511145011101 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 511145011102 putative active site [active] 511145011103 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 511145011104 putative active site [active] 511145011105 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 511145011106 O-Antigen ligase; Region: Wzy_C; pfam04932 511145011107 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 511145011108 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 511145011109 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10359 511145011110 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 511145011111 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 511145011112 Ligand binding site; other site 511145011113 metal-binding site 511145011114 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 511145011115 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 511145011116 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 511145011117 Ligand binding site; other site 511145011118 metal-binding site 511145011119 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 511145011120 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 511145011121 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 511145011122 putative ADP-binding pocket [chemical binding]; other site 511145011123 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 511145011124 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 511145011125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511145011126 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 511145011127 putative active site [active] 511145011128 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 511145011129 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 511145011130 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 511145011131 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 511145011132 active site 511145011133 (T/H)XGH motif; other site 511145011134 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 511145011135 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 511145011136 DNA binding site [nucleotide binding] 511145011137 catalytic residue [active] 511145011138 H2TH interface [polypeptide binding]; other site 511145011139 putative catalytic residues [active] 511145011140 turnover-facilitating residue; other site 511145011141 intercalation triad [nucleotide binding]; other site 511145011142 8OG recognition residue [nucleotide binding]; other site 511145011143 putative reading head residues; other site 511145011144 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 511145011145 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511145011146 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 511145011147 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 511145011148 hypothetical protein; Reviewed; Region: PRK00024 511145011149 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 511145011150 MPN+ (JAMM) motif; other site 511145011151 Zinc-binding site [ion binding]; other site 511145011152 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 511145011153 Flavoprotein; Region: Flavoprotein; cl19190 511145011154 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 511145011155 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 511145011156 trimer interface [polypeptide binding]; other site 511145011157 active site 511145011158 division inhibitor protein; Provisional; Region: slmA; PRK09480 511145011159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145011160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511145011161 active site 511145011162 hypothetical protein; Provisional; Region: PRK11820 511145011163 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 511145011164 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 511145011165 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 511145011166 BRO family, N-terminal domain; Region: Bro-N; pfam02498 511145011167 Predicted membrane protein [Function unknown]; Region: COG2860 511145011168 UPF0126 domain; Region: UPF0126; pfam03458 511145011169 UPF0126 domain; Region: UPF0126; pfam03458 511145011170 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 511145011171 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 511145011172 nucleotide binding pocket [chemical binding]; other site 511145011173 K-X-D-G motif; other site 511145011174 catalytic site [active] 511145011175 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 511145011176 Guanylate kinase; Region: Guanylate_kin; pfam00625 511145011177 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 511145011178 catalytic site [active] 511145011179 G-X2-G-X-G-K; other site 511145011180 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 511145011181 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 511145011182 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511145011183 Zn2+ binding site [ion binding]; other site 511145011184 Mg2+ binding site [ion binding]; other site 511145011185 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511145011186 synthetase active site [active] 511145011187 NTP binding site [chemical binding]; other site 511145011188 metal binding site [ion binding]; metal-binding site 511145011189 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 511145011190 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 511145011191 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 511145011192 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511145011193 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 511145011194 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 511145011195 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 511145011196 generic binding surface II; other site 511145011197 ssDNA binding site; other site 511145011198 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145011199 ATP binding site [chemical binding]; other site 511145011200 putative Mg++ binding site [ion binding]; other site 511145011201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145011202 nucleotide binding region [chemical binding]; other site 511145011203 ATP-binding site [chemical binding]; other site 511145011204 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 511145011205 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 511145011206 Sulfate transporter family; Region: Sulfate_transp; cl19250 511145011207 AsmA family; Region: AsmA; pfam05170 511145011208 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 511145011209 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 511145011210 putative alpha-glucosidase; Provisional; Region: PRK10658 511145011211 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 511145011212 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 511145011213 active site 511145011214 homotrimer interface [polypeptide binding]; other site 511145011215 catalytic site [active] 511145011216 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 511145011217 putative transporter; Provisional; Region: PRK11462 511145011218 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 511145011219 sugar efflux transporter B; Provisional; Region: PRK15011 511145011220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011221 putative substrate translocation pore; other site 511145011222 EamA-like transporter family; Region: EamA; pfam00892 511145011223 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 511145011224 EamA-like transporter family; Region: EamA; pfam00892 511145011225 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 511145011226 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 511145011227 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 511145011228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011229 putative substrate translocation pore; other site 511145011230 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 511145011231 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 511145011232 cryptic adenine deaminase; Provisional; Region: PRK10027 511145011233 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511145011234 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 511145011235 active site 511145011236 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 511145011237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011238 putative substrate translocation pore; other site 511145011239 regulatory protein UhpC; Provisional; Region: PRK11663 511145011240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011241 putative substrate translocation pore; other site 511145011242 sensory histidine kinase UhpB; Provisional; Region: PRK11644 511145011243 MASE1; Region: MASE1; pfam05231 511145011244 Histidine kinase; Region: HisKA_3; pfam07730 511145011245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145011246 ATP binding site [chemical binding]; other site 511145011247 Mg2+ binding site [ion binding]; other site 511145011248 G-X-G motif; other site 511145011249 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 511145011250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145011251 active site 511145011252 phosphorylation site [posttranslational modification] 511145011253 intermolecular recognition site; other site 511145011254 dimerization interface [polypeptide binding]; other site 511145011255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145011256 DNA binding residues [nucleotide binding] 511145011257 dimerization interface [polypeptide binding]; other site 511145011258 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 511145011259 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 511145011260 putative valine binding site [chemical binding]; other site 511145011261 dimer interface [polypeptide binding]; other site 511145011262 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 511145011263 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 511145011264 PYR/PP interface [polypeptide binding]; other site 511145011265 dimer interface [polypeptide binding]; other site 511145011266 TPP binding site [chemical binding]; other site 511145011267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511145011268 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 511145011269 TPP-binding site [chemical binding]; other site 511145011270 dimer interface [polypeptide binding]; other site 511145011271 ilvB operon leader peptide; Provisional; Region: PRK10214 511145011272 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 511145011273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011274 putative substrate translocation pore; other site 511145011275 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 511145011276 Domain of unknown function (DUF202); Region: DUF202; pfam02656 511145011277 Predicted membrane protein [Function unknown]; Region: COG2149 511145011278 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 511145011279 Sulfatase; Region: Sulfatase; pfam00884 511145011280 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 511145011281 Na binding site [ion binding]; other site 511145011282 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511145011283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145011284 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511145011285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145011286 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511145011287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145011288 DNA-binding site [nucleotide binding]; DNA binding site 511145011289 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 511145011290 putative transporter; Validated; Region: PRK03818 511145011291 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 511145011292 TrkA-C domain; Region: TrkA_C; pfam02080 511145011293 TrkA-C domain; Region: TrkA_C; pfam02080 511145011294 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 511145011295 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 511145011296 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 511145011297 putative dimer interface [polypeptide binding]; other site 511145011298 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 511145011299 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 511145011300 putative dimer interface [polypeptide binding]; other site 511145011301 hypothetical protein; Provisional; Region: PRK11616 511145011302 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 511145011303 putative oxidoreductase; Provisional; Region: PRK11445 511145011304 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 511145011305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011306 D-galactonate transporter; Region: 2A0114; TIGR00893 511145011307 putative substrate translocation pore; other site 511145011308 galactonate dehydratase; Provisional; Region: PRK14017 511145011309 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 511145011310 putative active site pocket [active] 511145011311 putative metal binding site [ion binding]; other site 511145011312 Entner-Doudoroff aldolase; Region: eda; TIGR01182 511145011313 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 511145011314 active site 511145011315 intersubunit interface [polypeptide binding]; other site 511145011316 catalytic residue [active] 511145011317 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 511145011318 Transcriptional regulators [Transcription]; Region: FadR; COG2186 511145011319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145011320 DNA-binding site [nucleotide binding]; DNA binding site 511145011321 FCD domain; Region: FCD; pfam07729 511145011322 hypothetical protein; Provisional; Region: PRK10215 511145011323 sugar phosphate phosphatase; Provisional; Region: PRK10513 511145011324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145011325 active site 511145011326 motif I; other site 511145011327 motif II; other site 511145011328 hypothetical protein; Provisional; Region: PRK11426 511145011329 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 511145011330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145011331 ATP binding site [chemical binding]; other site 511145011332 Mg2+ binding site [ion binding]; other site 511145011333 G-X-G motif; other site 511145011334 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511145011335 anchoring element; other site 511145011336 dimer interface [polypeptide binding]; other site 511145011337 ATP binding site [chemical binding]; other site 511145011338 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511145011339 active site 511145011340 putative metal-binding site [ion binding]; other site 511145011341 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511145011342 recF protein; Region: recf; TIGR00611 511145011343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145011344 Walker A/P-loop; other site 511145011345 ATP binding site [chemical binding]; other site 511145011346 Q-loop/lid; other site 511145011347 ABC transporter signature motif; other site 511145011348 Walker B; other site 511145011349 D-loop; other site 511145011350 H-loop/switch region; other site 511145011351 DNA polymerase III subunit beta; Validated; Region: PRK05643 511145011352 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 511145011353 putative DNA binding surface [nucleotide binding]; other site 511145011354 dimer interface [polypeptide binding]; other site 511145011355 beta-clamp/clamp loader binding surface; other site 511145011356 beta-clamp/translesion DNA polymerase binding surface; other site 511145011357 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 511145011358 DnaA N-terminal domain; Region: DnaA_N; pfam11638 511145011359 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 511145011360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145011361 Walker A motif; other site 511145011362 ATP binding site [chemical binding]; other site 511145011363 Walker B motif; other site 511145011364 arginine finger; other site 511145011365 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 511145011366 DnaA box-binding interface [nucleotide binding]; other site 511145011367 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 511145011368 ribonuclease P; Reviewed; Region: rnpA; PRK01732 511145011369 hypothetical protein; Validated; Region: PRK00041 511145011370 membrane protein insertase; Provisional; Region: PRK01318 511145011371 YidC periplasmic domain; Region: YidC_periplas; pfam14849 511145011372 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 511145011373 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 511145011374 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 511145011375 trmE is a tRNA modification GTPase; Region: trmE; cd04164 511145011376 G1 box; other site 511145011377 GTP/Mg2+ binding site [chemical binding]; other site 511145011378 Switch I region; other site 511145011379 G2 box; other site 511145011380 Switch II region; other site 511145011381 G3 box; other site 511145011382 G4 box; other site 511145011383 G5 box; other site 511145011384 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 511145011385 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 511145011386 Tryptophanase [Amino acid transport and metabolism]; Region: TnaA; COG3033 511145011387 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 511145011388 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511145011389 catalytic residue [active] 511145011390 tryptophan permease TnaB; Provisional; Region: PRK09664 511145011391 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 511145011392 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 511145011393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011394 putative substrate translocation pore; other site 511145011395 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 511145011396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145011397 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 511145011398 substrate binding pocket [chemical binding]; other site 511145011399 dimerization interface [polypeptide binding]; other site 511145011400 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 511145011401 Predicted flavoprotein [General function prediction only]; Region: COG0431 511145011402 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 511145011403 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 511145011404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145011405 active site 511145011406 motif I; other site 511145011407 motif II; other site 511145011408 putative inner membrane protein; Provisional; Region: PRK09823 511145011409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 511145011410 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 511145011411 active site 511145011412 trimer interface [polypeptide binding]; other site 511145011413 allosteric site; other site 511145011414 active site lid [active] 511145011415 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 511145011416 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 511145011417 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 511145011418 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 511145011419 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 511145011420 maltoporin; Provisional; Region: lamB; PRK09360 511145011421 trimer interface; other site 511145011422 sugar binding site [chemical binding]; other site 511145011423 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 511145011424 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 511145011425 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 511145011426 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511145011427 active site turn [active] 511145011428 phosphorylation site [posttranslational modification] 511145011429 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511145011430 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 511145011431 HPr interaction site; other site 511145011432 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511145011433 active site 511145011434 phosphorylation site [posttranslational modification] 511145011435 transcriptional antiterminator BglG; Provisional; Region: PRK09772 511145011436 CAT RNA binding domain; Region: CAT_RBD; pfam03123 511145011437 PRD domain; Region: PRD; pfam00874 511145011438 PRD domain; Region: PRD; pfam00874 511145011439 transcriptional regulator PhoU; Provisional; Region: PRK11115 511145011440 PhoU domain; Region: PhoU; pfam01895 511145011441 PhoU domain; Region: PhoU; pfam01895 511145011442 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 511145011443 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 511145011444 Walker A/P-loop; other site 511145011445 ATP binding site [chemical binding]; other site 511145011446 Q-loop/lid; other site 511145011447 ABC transporter signature motif; other site 511145011448 Walker B; other site 511145011449 D-loop; other site 511145011450 H-loop/switch region; other site 511145011451 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 511145011452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145011453 dimer interface [polypeptide binding]; other site 511145011454 conserved gate region; other site 511145011455 putative PBP binding loops; other site 511145011456 ABC-ATPase subunit interface; other site 511145011457 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 511145011458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145011459 dimer interface [polypeptide binding]; other site 511145011460 conserved gate region; other site 511145011461 putative PBP binding loops; other site 511145011462 ABC-ATPase subunit interface; other site 511145011463 phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918 511145011464 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145011465 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 511145011466 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 511145011467 glutaminase active site [active] 511145011468 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511145011469 dimer interface [polypeptide binding]; other site 511145011470 active site 511145011471 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511145011472 dimer interface [polypeptide binding]; other site 511145011473 active site 511145011474 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 511145011475 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 511145011476 Substrate binding site; other site 511145011477 Mg++ binding site; other site 511145011478 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 511145011479 active site 511145011480 substrate binding site [chemical binding]; other site 511145011481 CoA binding site [chemical binding]; other site 511145011482 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 511145011483 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 511145011484 gamma subunit interface [polypeptide binding]; other site 511145011485 epsilon subunit interface [polypeptide binding]; other site 511145011486 LBP interface [polypeptide binding]; other site 511145011487 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 511145011488 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511145011489 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 511145011490 alpha subunit interaction interface [polypeptide binding]; other site 511145011491 Walker A motif; other site 511145011492 ATP binding site [chemical binding]; other site 511145011493 Walker B motif; other site 511145011494 inhibitor binding site; inhibition site 511145011495 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511145011496 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 511145011497 core domain interface [polypeptide binding]; other site 511145011498 delta subunit interface [polypeptide binding]; other site 511145011499 epsilon subunit interface [polypeptide binding]; other site 511145011500 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 511145011501 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511145011502 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 511145011503 beta subunit interaction interface [polypeptide binding]; other site 511145011504 Walker A motif; other site 511145011505 ATP binding site [chemical binding]; other site 511145011506 Walker B motif; other site 511145011507 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511145011508 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 511145011509 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 511145011510 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 511145011511 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 511145011512 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 511145011513 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 511145011514 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 511145011515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145011516 S-adenosylmethionine binding site [chemical binding]; other site 511145011517 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 511145011518 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 511145011519 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 511145011520 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 511145011521 FMN-binding protein MioC; Provisional; Region: PRK09004 511145011522 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 511145011523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511145011524 putative DNA binding site [nucleotide binding]; other site 511145011525 putative Zn2+ binding site [ion binding]; other site 511145011526 AsnC family; Region: AsnC_trans_reg; pfam01037 511145011527 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 511145011528 dimer interface [polypeptide binding]; other site 511145011529 active site 511145011530 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 511145011531 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 511145011532 metal ion-dependent adhesion site (MIDAS); other site 511145011533 regulatory ATPase RavA; Provisional; Region: PRK13531 511145011534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145011535 Walker A motif; other site 511145011536 ATP binding site [chemical binding]; other site 511145011537 Walker B motif; other site 511145011538 arginine finger; other site 511145011539 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 511145011540 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 511145011541 D-ribose pyranase; Provisional; Region: PRK11797 511145011542 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 511145011543 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511145011544 Walker A/P-loop; other site 511145011545 ATP binding site [chemical binding]; other site 511145011546 Q-loop/lid; other site 511145011547 ABC transporter signature motif; other site 511145011548 Walker B; other site 511145011549 D-loop; other site 511145011550 H-loop/switch region; other site 511145011551 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511145011552 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145011553 TM-ABC transporter signature motif; other site 511145011554 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 511145011555 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 511145011556 ligand binding site [chemical binding]; other site 511145011557 dimerization interface [polypeptide binding]; other site 511145011558 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 511145011559 substrate binding site [chemical binding]; other site 511145011560 dimer interface [polypeptide binding]; other site 511145011561 ATP binding site [chemical binding]; other site 511145011562 transcriptional repressor RbsR; Provisional; Region: PRK10423 511145011563 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145011564 DNA binding site [nucleotide binding] 511145011565 domain linker motif; other site 511145011566 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 511145011567 dimerization interface [polypeptide binding]; other site 511145011568 ligand binding site [chemical binding]; other site 511145011569 putative transporter; Provisional; Region: PRK10504 511145011570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011571 putative substrate translocation pore; other site 511145011572 Transcriptional regulators [Transcription]; Region: FadR; COG2186 511145011573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145011574 DNA-binding site [nucleotide binding]; DNA binding site 511145011575 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 511145011576 transcriptional regulator HdfR; Provisional; Region: PRK03601 511145011577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145011578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511145011579 dimerization interface [polypeptide binding]; other site 511145011580 hypothetical protein; Provisional; Region: PRK11027 511145011581 putative ATP-dependent protease; Provisional; Region: PRK09862 511145011582 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 511145011583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145011584 Walker A motif; other site 511145011585 ATP binding site [chemical binding]; other site 511145011586 Walker B motif; other site 511145011587 arginine finger; other site 511145011588 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 511145011589 ilvG operon leader peptide; Provisional; Region: PRK10424 511145011590 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 511145011591 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 511145011592 homodimer interface [polypeptide binding]; other site 511145011593 substrate-cofactor binding pocket; other site 511145011594 catalytic residue [active] 511145011595 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 511145011596 threonine dehydratase; Reviewed; Region: PRK09224 511145011597 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 511145011598 tetramer interface [polypeptide binding]; other site 511145011599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145011600 catalytic residue [active] 511145011601 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 511145011602 putative Ile/Val binding site [chemical binding]; other site 511145011603 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 511145011604 putative Ile/Val binding site [chemical binding]; other site 511145011605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145011606 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 511145011607 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 511145011608 putative dimerization interface [polypeptide binding]; other site 511145011609 ketol-acid reductoisomerase; Validated; Region: PRK05225 511145011610 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 511145011611 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 511145011612 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 511145011613 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 511145011614 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 511145011615 Part of AAA domain; Region: AAA_19; pfam13245 511145011616 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 511145011617 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 511145011618 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 511145011619 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 511145011620 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511145011621 ATP binding site [chemical binding]; other site 511145011622 Mg++ binding site [ion binding]; other site 511145011623 motif III; other site 511145011624 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145011625 nucleotide binding region [chemical binding]; other site 511145011626 ATP-binding site [chemical binding]; other site 511145011627 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511145011628 catalytic residues [active] 511145011629 transcription termination factor Rho; Provisional; Region: rho; PRK09376 511145011630 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 511145011631 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 511145011632 RNA binding site [nucleotide binding]; other site 511145011633 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 511145011634 multimer interface [polypeptide binding]; other site 511145011635 Walker A motif; other site 511145011636 ATP binding site [chemical binding]; other site 511145011637 Walker B motif; other site 511145011638 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 511145011639 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 511145011640 Mg++ binding site [ion binding]; other site 511145011641 putative catalytic motif [active] 511145011642 substrate binding site [chemical binding]; other site 511145011643 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 511145011644 Chain length determinant protein; Region: Wzz; pfam02706 511145011645 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 511145011646 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 511145011647 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 511145011648 active site 511145011649 homodimer interface [polypeptide binding]; other site 511145011650 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 511145011651 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 511145011652 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 511145011653 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 511145011654 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 511145011655 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 511145011656 NAD binding site [chemical binding]; other site 511145011657 substrate binding site [chemical binding]; other site 511145011658 homodimer interface [polypeptide binding]; other site 511145011659 active site 511145011660 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 511145011661 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 511145011662 substrate binding site; other site 511145011663 tetramer interface; other site 511145011664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145011665 Coenzyme A binding pocket [chemical binding]; other site 511145011666 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 511145011667 inhibitor-cofactor binding pocket; inhibition site 511145011668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145011669 catalytic residue [active] 511145011670 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 511145011671 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 511145011672 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 511145011673 putative common antigen polymerase; Provisional; Region: PRK02975 511145011674 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 511145011675 putative transport protein YifK; Provisional; Region: PRK10746 511145011676 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 511145011677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145011678 FeS/SAM binding site; other site 511145011679 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 511145011680 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 511145011681 Sulfatase; Region: Sulfatase; pfam00884 511145011682 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 511145011683 HemY protein N-terminus; Region: HemY_N; pfam07219 511145011684 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 511145011685 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 511145011686 active site 511145011687 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 511145011688 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 511145011689 domain interfaces; other site 511145011690 active site 511145011691 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 511145011692 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 511145011693 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 511145011694 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 511145011695 putative iron binding site [ion binding]; other site 511145011696 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 511145011697 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 511145011698 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511145011699 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511145011700 hypothetical protein; Provisional; Region: PRK10963 511145011701 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 511145011702 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 511145011703 active site 511145011704 Int/Topo IB signature motif; other site 511145011705 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 511145011706 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 511145011707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145011708 motif II; other site 511145011709 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 511145011710 Part of AAA domain; Region: AAA_19; pfam13245 511145011711 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 511145011712 Predicted periplasmic protein [Function unknown]; Region: COG3698 511145011713 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 511145011714 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 511145011715 Cl binding site [ion binding]; other site 511145011716 oligomer interface [polypeptide binding]; other site 511145011717 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 511145011718 hypothetical protein; Provisional; Region: PRK11371 511145011719 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 511145011720 Multidrug resistance efflux transporter; Region: EmrE; cl19304 511145011721 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 511145011722 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 511145011723 CoenzymeA binding site [chemical binding]; other site 511145011724 subunit interaction site [polypeptide binding]; other site 511145011725 PHB binding site; other site 511145011726 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 511145011727 dimerization interface [polypeptide binding]; other site 511145011728 substrate binding site [chemical binding]; other site 511145011729 active site 511145011730 calcium binding site [ion binding]; other site 511145011731 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 511145011732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145011733 ATP binding site [chemical binding]; other site 511145011734 putative Mg++ binding site [ion binding]; other site 511145011735 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145011736 nucleotide binding region [chemical binding]; other site 511145011737 ATP-binding site [chemical binding]; other site 511145011738 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 511145011739 Helicase and RNase D C-terminal; Region: HRDC; smart00341 511145011740 threonine efflux system; Provisional; Region: PRK10229 511145011741 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 511145011742 lysophospholipase L2; Provisional; Region: PRK10749 511145011743 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 511145011744 putative hydrolase; Provisional; Region: PRK10976 511145011745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145011746 active site 511145011747 motif I; other site 511145011748 motif II; other site 511145011749 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 511145011750 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 511145011751 EamA-like transporter family; Region: EamA; pfam00892 511145011752 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 511145011753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145011754 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 511145011755 putative dimerization interface [polypeptide binding]; other site 511145011756 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 511145011757 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 511145011758 THF binding site; other site 511145011759 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 511145011760 substrate binding site [chemical binding]; other site 511145011761 THF binding site; other site 511145011762 zinc-binding site [ion binding]; other site 511145011763 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 511145011764 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 511145011765 uridine phosphorylase; Provisional; Region: PRK11178 511145011766 DNA recombination protein RmuC; Provisional; Region: PRK10361 511145011767 RmuC family; Region: RmuC; pfam02646 511145011768 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 511145011769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145011770 S-adenosylmethionine binding site [chemical binding]; other site 511145011771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 511145011772 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 511145011773 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 511145011774 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 511145011775 sec-independent translocase; Provisional; Region: PRK01770 511145011776 sec-independent translocase; Provisional; Region: tatB; PRK00404 511145011777 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 511145011778 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 511145011779 active site 511145011780 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 511145011781 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 511145011782 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 511145011783 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 511145011784 FMN reductase; Validated; Region: fre; PRK08051 511145011785 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 511145011786 FAD binding pocket [chemical binding]; other site 511145011787 FAD binding motif [chemical binding]; other site 511145011788 phosphate binding motif [ion binding]; other site 511145011789 beta-alpha-beta structure motif; other site 511145011790 NAD binding pocket [chemical binding]; other site 511145011791 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 511145011792 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 511145011793 dimer interface [polypeptide binding]; other site 511145011794 active site 511145011795 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 511145011796 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511145011797 substrate binding site [chemical binding]; other site 511145011798 oxyanion hole (OAH) forming residues; other site 511145011799 trimer interface [polypeptide binding]; other site 511145011800 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 511145011801 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511145011802 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511145011803 proline dipeptidase; Provisional; Region: PRK13607 511145011804 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 511145011805 active site 511145011806 hypothetical protein; Provisional; Region: PRK11568 511145011807 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 511145011808 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 511145011809 potassium transporter; Provisional; Region: PRK10750 511145011810 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 511145011811 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 511145011812 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 511145011813 Walker A motif; other site 511145011814 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 511145011815 GTP binding site; other site 511145011816 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 511145011817 serine/threonine protein kinase; Provisional; Region: PRK11768 511145011818 Phosphotransferase enzyme family; Region: APH; pfam01636 511145011819 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 511145011820 catalytic residues [active] 511145011821 hinge region; other site 511145011822 alpha helical domain; other site 511145011823 hypothetical protein; Provisional; Region: PRK11367 511145011824 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 511145011825 putative acyl-acceptor binding pocket; other site 511145011826 DNA polymerase I; Provisional; Region: PRK05755 511145011827 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 511145011828 active site 511145011829 metal binding site 1 [ion binding]; metal-binding site 511145011830 putative 5' ssDNA interaction site; other site 511145011831 metal binding site 3; metal-binding site 511145011832 metal binding site 2 [ion binding]; metal-binding site 511145011833 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 511145011834 putative DNA binding site [nucleotide binding]; other site 511145011835 putative metal binding site [ion binding]; other site 511145011836 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 511145011837 active site 511145011838 catalytic site [active] 511145011839 substrate binding site [chemical binding]; other site 511145011840 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 511145011841 active site 511145011842 DNA binding site [nucleotide binding] 511145011843 catalytic site [active] 511145011844 Predicted GTPase [General function prediction only]; Region: COG0218 511145011845 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 511145011846 G1 box; other site 511145011847 GTP/Mg2+ binding site [chemical binding]; other site 511145011848 Switch I region; other site 511145011849 G2 box; other site 511145011850 G3 box; other site 511145011851 Switch II region; other site 511145011852 G4 box; other site 511145011853 G5 box; other site 511145011854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 511145011855 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 511145011856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145011857 FeS/SAM binding site; other site 511145011858 HemN C-terminal domain; Region: HemN_C; pfam06969 511145011859 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 511145011860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145011861 active site 511145011862 phosphorylation site [posttranslational modification] 511145011863 intermolecular recognition site; other site 511145011864 dimerization interface [polypeptide binding]; other site 511145011865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145011866 Walker A motif; other site 511145011867 ATP binding site [chemical binding]; other site 511145011868 Walker B motif; other site 511145011869 arginine finger; other site 511145011870 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511145011871 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 511145011872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145011873 putative active site [active] 511145011874 heme pocket [chemical binding]; other site 511145011875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145011876 dimer interface [polypeptide binding]; other site 511145011877 phosphorylation site [posttranslational modification] 511145011878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145011879 ATP binding site [chemical binding]; other site 511145011880 Mg2+ binding site [ion binding]; other site 511145011881 G-X-G motif; other site 511145011882 glutamine synthetase; Provisional; Region: glnA; PRK09469 511145011883 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 511145011884 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 511145011885 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 511145011886 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 511145011887 G1 box; other site 511145011888 putative GEF interaction site [polypeptide binding]; other site 511145011889 GTP/Mg2+ binding site [chemical binding]; other site 511145011890 Switch I region; other site 511145011891 G2 box; other site 511145011892 G3 box; other site 511145011893 Switch II region; other site 511145011894 G4 box; other site 511145011895 G5 box; other site 511145011896 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 511145011897 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 511145011898 transcriptional regulator protein; Region: phnR; TIGR03337 511145011899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145011900 DNA-binding site [nucleotide binding]; DNA binding site 511145011901 UTRA domain; Region: UTRA; pfam07702 511145011902 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 511145011903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011904 putative substrate translocation pore; other site 511145011905 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 511145011906 outer membrane porin L; Provisional; Region: ompL; PRK09980 511145011907 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511145011908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011909 putative substrate translocation pore; other site 511145011910 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511145011911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145011912 putative substrate translocation pore; other site 511145011913 alpha-glucosidase; Provisional; Region: PRK10426 511145011914 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 511145011915 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 511145011916 putative active site [active] 511145011917 putative catalytic site [active] 511145011918 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 511145011919 active site 511145011920 catalytic residues [active] 511145011921 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 511145011922 dimerization interface [polypeptide binding]; other site 511145011923 putative active cleft [active] 511145011924 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 511145011925 catalytic residue [active] 511145011926 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 511145011927 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 511145011928 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 511145011929 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 511145011930 substrate binding site [chemical binding]; other site 511145011931 ATP binding site [chemical binding]; other site 511145011932 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511145011933 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511145011934 putative DNA binding site [nucleotide binding]; other site 511145011935 putative Zn2+ binding site [ion binding]; other site 511145011936 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145011937 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 511145011938 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 511145011939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145011940 motif II; other site 511145011941 hypothetical protein; Reviewed; Region: PRK01637 511145011942 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 511145011943 putative active site [active] 511145011944 dimerization interface [polypeptide binding]; other site 511145011945 putative tRNAtyr binding site [nucleotide binding]; other site 511145011946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145011947 Coenzyme A binding pocket [chemical binding]; other site 511145011948 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 511145011949 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 511145011950 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 511145011951 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 511145011952 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 511145011953 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145011954 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 511145011955 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 511145011956 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 511145011957 [4Fe-4S] binding site [ion binding]; other site 511145011958 molybdopterin cofactor binding site; other site 511145011959 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 511145011960 molybdopterin cofactor binding site; other site 511145011961 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 511145011962 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 511145011963 putative frv operon regulatory protein; Provisional; Region: PRK09863 511145011964 HTH domain; Region: HTH_11; pfam08279 511145011965 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145011966 active site 511145011967 phosphorylation site [posttranslational modification] 511145011968 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511145011969 oligomer interface [polypeptide binding]; other site 511145011970 active site 511145011971 metal binding site [ion binding]; metal-binding site 511145011972 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 511145011973 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 511145011974 active site 511145011975 P-loop; other site 511145011976 phosphorylation site [posttranslational modification] 511145011977 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 511145011978 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145011979 active site 511145011980 phosphorylation site [posttranslational modification] 511145011981 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 511145011982 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 511145011983 intersubunit interface [polypeptide binding]; other site 511145011984 active site 511145011985 Zn2+ binding site [ion binding]; other site 511145011986 L-rhamnose isomerase; Provisional; Region: PRK01076 511145011987 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 511145011988 N- and C-terminal domain interface [polypeptide binding]; other site 511145011989 active site 511145011990 putative catalytic site [active] 511145011991 metal binding site [ion binding]; metal-binding site 511145011992 ATP binding site [chemical binding]; other site 511145011993 rhamnulokinase; Provisional; Region: rhaB; PRK10640 511145011994 carbohydrate binding site [chemical binding]; other site 511145011995 transcriptional activator RhaS; Provisional; Region: PRK13503 511145011996 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511145011997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145011998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145011999 transcriptional activator RhaR; Provisional; Region: PRK13500 511145012000 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511145012001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145012002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145012003 Sugar transport protein; Region: Sugar_transport; cl19288 511145012004 superoxide dismutase; Provisional; Region: PRK10925 511145012005 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 511145012006 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 511145012007 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 511145012008 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 511145012009 MOSC domain; Region: MOSC; pfam03473 511145012010 3-alpha domain; Region: 3-alpha; pfam03475 511145012011 two-component sensor protein; Provisional; Region: cpxA; PRK09470 511145012012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145012013 dimerization interface [polypeptide binding]; other site 511145012014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145012015 dimer interface [polypeptide binding]; other site 511145012016 phosphorylation site [posttranslational modification] 511145012017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145012018 ATP binding site [chemical binding]; other site 511145012019 Mg2+ binding site [ion binding]; other site 511145012020 G-X-G motif; other site 511145012021 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 511145012022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145012023 active site 511145012024 intermolecular recognition site; other site 511145012025 dimerization interface [polypeptide binding]; other site 511145012026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145012027 DNA binding site [nucleotide binding] 511145012028 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 511145012029 dimer interface [polypeptide binding]; other site 511145012030 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 511145012031 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 511145012032 active site 511145012033 ADP/pyrophosphate binding site [chemical binding]; other site 511145012034 dimerization interface [polypeptide binding]; other site 511145012035 allosteric effector site; other site 511145012036 fructose-1,6-bisphosphate binding site; other site 511145012037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511145012038 substrate binding pocket [chemical binding]; other site 511145012039 membrane-bound complex binding site; other site 511145012040 hinge residues; other site 511145012041 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 511145012042 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 511145012043 substrate binding site [chemical binding]; other site 511145012044 dimer interface [polypeptide binding]; other site 511145012045 catalytic triad [active] 511145012046 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 511145012047 Predicted membrane protein [Function unknown]; Region: COG3152 511145012048 hypothetical protein; Provisional; Region: PRK09981 511145012049 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511145012050 Ligand Binding Site [chemical binding]; other site 511145012051 ferredoxin-NADP reductase; Provisional; Region: PRK10926 511145012052 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 511145012053 FAD binding pocket [chemical binding]; other site 511145012054 FAD binding motif [chemical binding]; other site 511145012055 phosphate binding motif [ion binding]; other site 511145012056 beta-alpha-beta structure motif; other site 511145012057 NAD binding pocket [chemical binding]; other site 511145012058 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 511145012059 putative active site [active] 511145012060 glycerol kinase; Provisional; Region: glpK; PRK00047 511145012061 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 511145012062 N- and C-terminal domain interface [polypeptide binding]; other site 511145012063 active site 511145012064 MgATP binding site [chemical binding]; other site 511145012065 catalytic site [active] 511145012066 metal binding site [ion binding]; metal-binding site 511145012067 glycerol binding site [chemical binding]; other site 511145012068 homotetramer interface [polypeptide binding]; other site 511145012069 homodimer interface [polypeptide binding]; other site 511145012070 FBP binding site [chemical binding]; other site 511145012071 protein IIAGlc interface [polypeptide binding]; other site 511145012072 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 511145012073 amphipathic channel; other site 511145012074 Asn-Pro-Ala signature motifs; other site 511145012075 septal ring assembly protein ZapB; Provisional; Region: PRK15422 511145012076 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 511145012077 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 511145012078 putative active site [active] 511145012079 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 511145012080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145012081 Walker A motif; other site 511145012082 ATP binding site [chemical binding]; other site 511145012083 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 511145012084 Walker B motif; other site 511145012085 arginine finger; other site 511145012086 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 511145012087 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 511145012088 active site 511145012089 HslU subunit interaction site [polypeptide binding]; other site 511145012090 essential cell division protein FtsN; Provisional; Region: PRK10927 511145012091 Sporulation related domain; Region: SPOR; pfam05036 511145012092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145012093 DNA binding site [nucleotide binding] 511145012094 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 511145012095 domain linker motif; other site 511145012096 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 511145012097 dimerization interface [polypeptide binding]; other site 511145012098 ligand binding site [chemical binding]; other site 511145012099 primosome assembly protein PriA; Validated; Region: PRK05580 511145012100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145012101 ATP binding site [chemical binding]; other site 511145012102 putative Mg++ binding site [ion binding]; other site 511145012103 helicase superfamily c-terminal domain; Region: HELICc; smart00490 511145012104 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 511145012105 hypothetical protein; Provisional; Region: PRK10030 511145012106 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 511145012107 dimerization interface [polypeptide binding]; other site 511145012108 DNA binding site [nucleotide binding] 511145012109 corepressor binding sites; other site 511145012110 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511145012111 homodimer interface [polypeptide binding]; other site 511145012112 substrate-cofactor binding pocket; other site 511145012113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145012114 catalytic residue [active] 511145012115 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 511145012116 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 511145012117 putative catalytic residues [active] 511145012118 putative nucleotide binding site [chemical binding]; other site 511145012119 putative aspartate binding site [chemical binding]; other site 511145012120 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 511145012121 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 511145012122 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 511145012123 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 511145012124 FAD binding site [chemical binding]; other site 511145012125 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 511145012126 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 511145012127 heme binding site [chemical binding]; other site 511145012128 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 511145012129 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 511145012130 EamA-like transporter family; Region: EamA; pfam00892 511145012131 EamA-like transporter family; Region: EamA; pfam00892 511145012132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 511145012133 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 511145012134 dimer interface [polypeptide binding]; other site 511145012135 active site 511145012136 metal binding site [ion binding]; metal-binding site 511145012137 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 511145012138 active site 511145012139 intersubunit interactions; other site 511145012140 catalytic residue [active] 511145012141 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511145012142 dimerization domain swap beta strand [polypeptide binding]; other site 511145012143 regulatory protein interface [polypeptide binding]; other site 511145012144 active site 511145012145 regulatory phosphorylation site [posttranslational modification]; other site 511145012146 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 511145012147 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 511145012148 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511145012149 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511145012150 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145012151 active site 511145012152 phosphorylation site [posttranslational modification] 511145012153 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 511145012154 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 511145012155 active site 511145012156 P-loop; other site 511145012157 phosphorylation site [posttranslational modification] 511145012158 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 511145012159 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 511145012160 dimer interface [polypeptide binding]; other site 511145012161 active site 511145012162 glycine loop; other site 511145012163 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 511145012164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145012165 FeS/SAM binding site; other site 511145012166 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 511145012167 active site 511145012168 P-loop; other site 511145012169 phosphorylation site [posttranslational modification] 511145012170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145012171 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511145012172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145012173 hypothetical protein; Provisional; Region: PRK10649 511145012174 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 511145012175 Sulfatase; Region: Sulfatase; pfam00884 511145012176 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 511145012177 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 511145012178 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 511145012179 metal binding site [ion binding]; metal-binding site 511145012180 putative dimer interface [polypeptide binding]; other site 511145012181 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 511145012182 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 511145012183 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 511145012184 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 511145012185 nucleotide binding site [chemical binding]; other site 511145012186 N-acetyl-L-glutamate binding site [chemical binding]; other site 511145012187 argininosuccinate lyase; Provisional; Region: PRK04833 511145012188 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 511145012189 active sites [active] 511145012190 tetramer interface [polypeptide binding]; other site 511145012191 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 511145012192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145012193 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 511145012194 dimerization interface [polypeptide binding]; other site 511145012195 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 511145012196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 511145012197 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511145012198 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 511145012199 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 511145012200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145012201 hypothetical protein; Provisional; Region: PRK11056 511145012202 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 511145012203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145012204 S-adenosylmethionine binding site [chemical binding]; other site 511145012205 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 511145012206 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 511145012207 N-terminal plug; other site 511145012208 ligand-binding site [chemical binding]; other site 511145012209 glutamate racemase; Provisional; Region: PRK00865 511145012210 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 511145012211 FAD binding domain; Region: FAD_binding_4; pfam01565 511145012212 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 511145012213 Biotin operon repressor [Transcription]; Region: BirA; COG1654 511145012214 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 511145012215 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 511145012216 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 511145012217 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 511145012218 ATP-binding site [chemical binding]; other site 511145012219 CoA-binding site [chemical binding]; other site 511145012220 Mg2+-binding site [ion binding]; other site 511145012221 elongation factor Tu; Reviewed; Region: PRK00049 511145012222 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511145012223 G1 box; other site 511145012224 GEF interaction site [polypeptide binding]; other site 511145012225 GTP/Mg2+ binding site [chemical binding]; other site 511145012226 Switch I region; other site 511145012227 G2 box; other site 511145012228 G3 box; other site 511145012229 Switch II region; other site 511145012230 G4 box; other site 511145012231 G5 box; other site 511145012232 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511145012233 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511145012234 Antibiotic Binding Site [chemical binding]; other site 511145012235 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 511145012236 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 511145012237 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 511145012238 putative homodimer interface [polypeptide binding]; other site 511145012239 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 511145012240 heterodimer interface [polypeptide binding]; other site 511145012241 homodimer interface [polypeptide binding]; other site 511145012242 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 511145012243 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 511145012244 23S rRNA interface [nucleotide binding]; other site 511145012245 L7/L12 interface [polypeptide binding]; other site 511145012246 putative thiostrepton binding site; other site 511145012247 L25 interface [polypeptide binding]; other site 511145012248 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 511145012249 mRNA/rRNA interface [nucleotide binding]; other site 511145012250 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 511145012251 23S rRNA interface [nucleotide binding]; other site 511145012252 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 511145012253 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 511145012254 core dimer interface [polypeptide binding]; other site 511145012255 peripheral dimer interface [polypeptide binding]; other site 511145012256 L10 interface [polypeptide binding]; other site 511145012257 L11 interface [polypeptide binding]; other site 511145012258 putative EF-Tu interaction site [polypeptide binding]; other site 511145012259 putative EF-G interaction site [polypeptide binding]; other site 511145012260 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 511145012261 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 511145012262 RPB12 interaction site [polypeptide binding]; other site 511145012263 RPB1 interaction site [polypeptide binding]; other site 511145012264 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 511145012265 RPB10 interaction site [polypeptide binding]; other site 511145012266 RPB11 interaction site [polypeptide binding]; other site 511145012267 RPB3 interaction site [polypeptide binding]; other site 511145012268 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 511145012269 beta and beta' interface [polypeptide binding]; other site 511145012270 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 511145012271 beta' and sigma factor interface [polypeptide binding]; other site 511145012272 Zn-binding [ion binding]; other site 511145012273 active site region [active] 511145012274 catalytic site [active] 511145012275 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 511145012276 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 511145012277 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 511145012278 G-loop; other site 511145012279 DNA binding site [nucleotide binding] 511145012280 stationary phase growth adaptation protein; Provisional; Region: PRK09717 511145012281 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 511145012282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145012283 FeS/SAM binding site; other site 511145012284 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 511145012285 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 511145012286 ThiS interaction site; other site 511145012287 putative active site [active] 511145012288 tetramer interface [polypeptide binding]; other site 511145012289 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 511145012290 thiS-thiF/thiG interaction site; other site 511145012291 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 511145012292 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 511145012293 ATP binding site [chemical binding]; other site 511145012294 substrate interface [chemical binding]; other site 511145012295 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 511145012296 thiamine phosphate binding site [chemical binding]; other site 511145012297 active site 511145012298 pyrophosphate binding site [ion binding]; other site 511145012299 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 511145012300 ThiC-associated domain; Region: ThiC-associated; pfam13667 511145012301 ThiC family; Region: ThiC; pfam01964 511145012302 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 511145012303 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 511145012304 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 511145012305 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 511145012306 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 511145012307 putative NADH binding site [chemical binding]; other site 511145012308 putative active site [active] 511145012309 nudix motif; other site 511145012310 putative metal binding site [ion binding]; other site 511145012311 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 511145012312 substrate binding site [chemical binding]; other site 511145012313 active site 511145012314 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 511145012315 Active_site [active] 511145012316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 511145012317 histone-like DNA-binding protein HU; Region: HU; cd13831 511145012318 dimer interface [polypeptide binding]; other site 511145012319 DNA binding site [nucleotide binding] 511145012320 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 511145012321 zinc resistance protein; Provisional; Region: zraP; PRK11546 511145012322 dimer interface [polypeptide binding]; other site 511145012323 sensor protein ZraS; Provisional; Region: PRK10364 511145012324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145012325 dimer interface [polypeptide binding]; other site 511145012326 phosphorylation site [posttranslational modification] 511145012327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145012328 ATP binding site [chemical binding]; other site 511145012329 Mg2+ binding site [ion binding]; other site 511145012330 G-X-G motif; other site 511145012331 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 511145012332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145012333 active site 511145012334 phosphorylation site [posttranslational modification] 511145012335 intermolecular recognition site; other site 511145012336 dimerization interface [polypeptide binding]; other site 511145012337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145012338 Walker A motif; other site 511145012339 ATP binding site [chemical binding]; other site 511145012340 Walker B motif; other site 511145012341 arginine finger; other site 511145012342 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511145012343 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 511145012344 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 511145012345 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 511145012346 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 511145012347 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 511145012348 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 511145012349 purine monophosphate binding site [chemical binding]; other site 511145012350 dimer interface [polypeptide binding]; other site 511145012351 putative catalytic residues [active] 511145012352 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 511145012353 hypothetical protein; Provisional; Region: PRK10039 511145012354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511145012355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145012356 Coenzyme A binding pocket [chemical binding]; other site 511145012357 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 511145012358 proposed active site lysine [active] 511145012359 conserved cys residue [active] 511145012360 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 511145012361 active site 511145012362 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 511145012363 tetramer interface [polypeptide binding]; other site 511145012364 active site 511145012365 Mg2+/Mn2+ binding site [ion binding]; other site 511145012366 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 511145012367 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 511145012368 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 511145012369 transcriptional repressor IclR; Provisional; Region: PRK11569 511145012370 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 511145012371 Bacterial transcriptional regulator; Region: IclR; pfam01614 511145012372 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 511145012373 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 511145012374 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 511145012375 substrate binding pocket [chemical binding]; other site 511145012376 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 511145012377 B12 binding site [chemical binding]; other site 511145012378 cobalt ligand [ion binding]; other site 511145012379 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 511145012380 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 511145012381 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 511145012382 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 511145012383 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 511145012384 active site pocket [active] 511145012385 oxyanion hole [active] 511145012386 catalytic triad [active] 511145012387 active site nucleophile [active] 511145012388 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 511145012389 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511145012390 RNA binding surface [nucleotide binding]; other site 511145012391 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 511145012392 probable active site [active] 511145012393 hypothetical protein; Provisional; Region: PRK10515 511145012394 aspartate kinase III; Validated; Region: PRK09084 511145012395 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 511145012396 nucleotide binding site [chemical binding]; other site 511145012397 putative catalytic residues [active] 511145012398 aspartate binding site [chemical binding]; other site 511145012399 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 511145012400 lysine allosteric regulatory site; other site 511145012401 dimer interface [polypeptide binding]; other site 511145012402 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 511145012403 dimer interface [polypeptide binding]; other site 511145012404 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 511145012405 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 511145012406 active site 511145012407 dimer interface [polypeptide binding]; other site 511145012408 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 511145012409 dimer interface [polypeptide binding]; other site 511145012410 active site 511145012411 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 511145012412 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 511145012413 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 511145012414 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 511145012415 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 511145012416 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 511145012417 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 511145012418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145012419 putative substrate translocation pore; other site 511145012420 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511145012421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145012422 dimer interface [polypeptide binding]; other site 511145012423 conserved gate region; other site 511145012424 putative PBP binding loops; other site 511145012425 ABC-ATPase subunit interface; other site 511145012426 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 511145012427 Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785 511145012428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511145012429 dimer interface [polypeptide binding]; other site 511145012430 conserved gate region; other site 511145012431 putative PBP binding loops; other site 511145012432 ABC-ATPase subunit interface; other site 511145012433 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 511145012434 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 511145012435 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 511145012436 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 511145012437 Walker A/P-loop; other site 511145012438 ATP binding site [chemical binding]; other site 511145012439 Q-loop/lid; other site 511145012440 ABC transporter signature motif; other site 511145012441 Walker B; other site 511145012442 D-loop; other site 511145012443 H-loop/switch region; other site 511145012444 TOBE domain; Region: TOBE_2; pfam08402 511145012445 maltoporin; Provisional; Region: lamB; PRK09360 511145012446 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 511145012447 trimer interface; other site 511145012448 sugar binding site [chemical binding]; other site 511145012449 maltose regulon periplasmic protein; Provisional; Region: PRK10564 511145012450 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 511145012451 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 511145012452 putative active site [active] 511145012453 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 511145012454 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 511145012455 putative acyl-acceptor binding pocket; other site 511145012456 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 511145012457 putative active site [active] 511145012458 trimer interface [polypeptide binding]; other site 511145012459 putative active site [active] 511145012460 Zn binding site [ion binding]; other site 511145012461 LexA repressor; Validated; Region: PRK00215 511145012462 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 511145012463 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511145012464 Catalytic site [active] 511145012465 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 511145012466 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 511145012467 hypothetical protein; Provisional; Region: PRK10428 511145012468 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 511145012469 metal binding site 2 [ion binding]; metal-binding site 511145012470 putative DNA binding helix; other site 511145012471 metal binding site 1 [ion binding]; metal-binding site 511145012472 dimer interface [polypeptide binding]; other site 511145012473 structural Zn2+ binding site [ion binding]; other site 511145012474 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 511145012475 phage shock protein G; Reviewed; Region: pspG; PRK09459 511145012476 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 511145012477 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 511145012478 NADP binding site [chemical binding]; other site 511145012479 dimer interface [polypeptide binding]; other site 511145012480 replicative DNA helicase; Provisional; Region: PRK08006 511145012481 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 511145012482 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 511145012483 Walker A motif; other site 511145012484 ATP binding site [chemical binding]; other site 511145012485 Walker B motif; other site 511145012486 DNA binding loops [nucleotide binding] 511145012487 alanine racemase; Reviewed; Region: alr; PRK00053 511145012488 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 511145012489 active site 511145012490 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511145012491 substrate binding site [chemical binding]; other site 511145012492 catalytic residues [active] 511145012493 dimer interface [polypeptide binding]; other site 511145012494 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 511145012495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145012496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145012497 homodimer interface [polypeptide binding]; other site 511145012498 catalytic residue [active] 511145012499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145012500 active site 511145012501 motif I; other site 511145012502 motif II; other site 511145012503 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 511145012504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 511145012505 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 511145012506 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511145012507 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511145012508 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 511145012509 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 511145012510 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 511145012511 dimer interface [polypeptide binding]; other site 511145012512 ssDNA binding site [nucleotide binding]; other site 511145012513 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511145012514 putative single-stranded DNA-binding protein; Region: PHA01740 511145012515 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 511145012516 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 511145012517 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 511145012518 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 511145012519 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145012520 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 511145012521 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 511145012522 DNA binding residues [nucleotide binding] 511145012523 dimer interface [polypeptide binding]; other site 511145012524 [2Fe-2S] cluster binding site [ion binding]; other site 511145012525 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 511145012526 Sulfate transporter family; Region: Sulfate_transp; cl19250 511145012527 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 511145012528 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 511145012529 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 511145012530 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 511145012531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 511145012532 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 511145012533 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 511145012534 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 511145012535 Na binding site [ion binding]; other site 511145012536 Predicted membrane protein [Function unknown]; Region: COG3162 511145012537 acetyl-CoA synthetase; Provisional; Region: PRK00174 511145012538 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 511145012539 active site 511145012540 CoA binding site [chemical binding]; other site 511145012541 acyl-activating enzyme (AAE) consensus motif; other site 511145012542 AMP binding site [chemical binding]; other site 511145012543 acetate binding site [chemical binding]; other site 511145012544 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 511145012545 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 511145012546 Cytochrome c7; Region: Cytochrome_C7; cl19206 511145012547 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 511145012548 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 511145012549 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 511145012550 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 511145012551 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 511145012552 heme lyase subunit NrfE; Provisional; Region: PRK10369 511145012553 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 511145012554 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 511145012555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511145012556 binding surface 511145012557 TPR motif; other site 511145012558 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 511145012559 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 511145012560 Sel1-like repeats; Region: SEL1; smart00671 511145012561 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 511145012562 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 511145012563 [4Fe-4S] binding site [ion binding]; other site 511145012564 molybdopterin cofactor binding site; other site 511145012565 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 511145012566 molybdopterin cofactor binding site; other site 511145012567 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 511145012568 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 511145012569 Outer membrane efflux protein; Region: OEP; pfam02321 511145012570 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 511145012571 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 511145012572 multidrug resistance protein MdtN; Provisional; Region: PRK10476 511145012573 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511145012574 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 511145012575 HlyD family secretion protein; Region: HlyD_3; pfam13437 511145012576 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 511145012577 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511145012578 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 511145012579 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 511145012580 D-allose kinase; Provisional; Region: PRK09698 511145012581 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511145012582 nucleotide binding site [chemical binding]; other site 511145012583 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 511145012584 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 511145012585 substrate binding site [chemical binding]; other site 511145012586 hexamer interface [polypeptide binding]; other site 511145012587 metal binding site [ion binding]; metal-binding site 511145012588 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145012589 TM-ABC transporter signature motif; other site 511145012590 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 511145012591 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511145012592 Walker A/P-loop; other site 511145012593 ATP binding site [chemical binding]; other site 511145012594 Q-loop/lid; other site 511145012595 ABC transporter signature motif; other site 511145012596 Walker B; other site 511145012597 D-loop; other site 511145012598 H-loop/switch region; other site 511145012599 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511145012600 D-allose transporter subunit; Provisional; Region: PRK09701 511145012601 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 511145012602 ligand binding site [chemical binding]; other site 511145012603 dimerization interface [polypeptide binding]; other site 511145012604 zinc binding site [ion binding]; other site 511145012605 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 511145012606 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 511145012607 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 511145012608 putative active site [active] 511145012609 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 511145012610 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 511145012611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145012612 Coenzyme A binding pocket [chemical binding]; other site 511145012613 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 511145012614 Guanylate kinase; Region: Guanylate_kin; pfam00625 511145012615 active site 511145012616 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 511145012617 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511145012618 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 511145012619 active site 511145012620 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 511145012621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511145012622 Walker A/P-loop; other site 511145012623 ATP binding site [chemical binding]; other site 511145012624 Q-loop/lid; other site 511145012625 ABC transporter signature motif; other site 511145012626 Walker B; other site 511145012627 D-loop; other site 511145012628 H-loop/switch region; other site 511145012629 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 511145012630 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511145012631 Walker A/P-loop; other site 511145012632 ATP binding site [chemical binding]; other site 511145012633 Q-loop/lid; other site 511145012634 ABC transporter signature motif; other site 511145012635 Walker B; other site 511145012636 D-loop; other site 511145012637 H-loop/switch region; other site 511145012638 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511145012639 Phosphonate metabolizm protein PhnJ; Region: PhnJ; pfam06007 511145012640 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 511145012641 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 511145012642 Phosphonate metabolizm protein PhnG; Region: PhnG; pfam06754 511145012643 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 511145012644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145012645 DNA-binding site [nucleotide binding]; DNA binding site 511145012646 UTRA domain; Region: UTRA; pfam07702 511145012647 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 511145012648 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 511145012649 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 511145012650 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 511145012651 Walker A/P-loop; other site 511145012652 ATP binding site [chemical binding]; other site 511145012653 Q-loop/lid; other site 511145012654 ABC transporter signature motif; other site 511145012655 Walker B; other site 511145012656 D-loop; other site 511145012657 H-loop/switch region; other site 511145012658 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 511145012659 dimer interface [polypeptide binding]; other site 511145012660 hypothetical protein; Provisional; Region: PRK10220 511145012661 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 511145012662 PhnA protein; Region: PhnA; pfam03831 511145012663 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 511145012664 G1 box; other site 511145012665 GTP/Mg2+ binding site [chemical binding]; other site 511145012666 G2 box; other site 511145012667 Switch I region; other site 511145012668 G3 box; other site 511145012669 Switch II region; other site 511145012670 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 511145012671 G2 box; other site 511145012672 Switch I region; other site 511145012673 G3 box; other site 511145012674 Switch II region; other site 511145012675 G4 box; other site 511145012676 G5 box; other site 511145012677 YjcZ-like protein; Region: YjcZ; pfam13990 511145012678 proline/glycine betaine transporter; Provisional; Region: PRK10642 511145012679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145012680 putative substrate translocation pore; other site 511145012681 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 511145012682 sensor protein BasS/PmrB; Provisional; Region: PRK10755 511145012683 HAMP domain; Region: HAMP; pfam00672 511145012684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145012685 dimer interface [polypeptide binding]; other site 511145012686 phosphorylation site [posttranslational modification] 511145012687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145012688 ATP binding site [chemical binding]; other site 511145012689 Mg2+ binding site [ion binding]; other site 511145012690 G-X-G motif; other site 511145012691 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 511145012692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145012693 active site 511145012694 phosphorylation site [posttranslational modification] 511145012695 intermolecular recognition site; other site 511145012696 dimerization interface [polypeptide binding]; other site 511145012697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145012698 DNA binding site [nucleotide binding] 511145012699 putative metal dependent hydrolase; Provisional; Region: PRK11598 511145012700 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 511145012701 Sulfatase; Region: Sulfatase; pfam00884 511145012702 arginine:agmatin antiporter; Provisional; Region: PRK10644 511145012703 Spore germination protein; Region: Spore_permease; cl17796 511145012704 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145012705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145012706 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511145012707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145012708 arginine decarboxylase; Provisional; Region: PRK15029 511145012709 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 511145012710 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 511145012711 homodimer interface [polypeptide binding]; other site 511145012712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145012713 catalytic residue [active] 511145012714 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 511145012715 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 511145012716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145012717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145012718 alpha-galactosidase; Provisional; Region: PRK15076 511145012719 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 511145012720 NAD binding site [chemical binding]; other site 511145012721 sugar binding site [chemical binding]; other site 511145012722 divalent metal binding site [ion binding]; other site 511145012723 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 511145012724 dimer interface [polypeptide binding]; other site 511145012725 melibiose:sodium symporter; Provisional; Region: PRK10429 511145012726 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511145012727 hypothetical protein; Provisional; Region: PRK09867 511145012728 fumarate hydratase FumB; Provisional; Region: PRK15391 511145012729 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 511145012730 Fumarase C-terminus; Region: Fumerase_C; pfam05683 511145012731 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 511145012732 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 511145012733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145012734 active site 511145012735 phosphorylation site [posttranslational modification] 511145012736 intermolecular recognition site; other site 511145012737 dimerization interface [polypeptide binding]; other site 511145012738 sensory histidine kinase DcuS; Provisional; Region: PRK11086 511145012739 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 511145012740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511145012741 putative active site [active] 511145012742 heme pocket [chemical binding]; other site 511145012743 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 511145012744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145012745 ATP binding site [chemical binding]; other site 511145012746 Mg2+ binding site [ion binding]; other site 511145012747 G-X-G motif; other site 511145012748 Uncharacterized conserved protein [Function unknown]; Region: COG3592 511145012749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145012750 Coenzyme A binding pocket [chemical binding]; other site 511145012751 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 511145012752 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 511145012753 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 511145012754 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 511145012755 dimer interface [polypeptide binding]; other site 511145012756 putative anticodon binding site; other site 511145012757 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 511145012758 motif 1; other site 511145012759 active site 511145012760 motif 2; other site 511145012761 motif 3; other site 511145012762 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 511145012763 POT family; Region: PTR2; cl17359 511145012764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145012765 putative substrate translocation pore; other site 511145012766 lysine decarboxylase CadA; Provisional; Region: PRK15400 511145012767 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 511145012768 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 511145012769 homodimer interface [polypeptide binding]; other site 511145012770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145012771 catalytic residue [active] 511145012772 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 511145012773 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 511145012774 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 511145012775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145012776 DNA binding site [nucleotide binding] 511145012777 putative transcriptional regulator; Provisional; Region: PRK11640 511145012778 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 511145012779 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 511145012780 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 511145012781 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 511145012782 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 511145012783 DsbD alpha interface [polypeptide binding]; other site 511145012784 catalytic residues [active] 511145012785 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 511145012786 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 511145012787 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 511145012788 Aspartase; Region: Aspartase; cd01357 511145012789 active sites [active] 511145012790 tetramer interface [polypeptide binding]; other site 511145012791 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 511145012792 putative transporter; Provisional; Region: PRK11021 511145012793 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145012794 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 511145012795 oligomerisation interface [polypeptide binding]; other site 511145012796 mobile loop; other site 511145012797 roof hairpin; other site 511145012798 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 511145012799 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 511145012800 ring oligomerisation interface [polypeptide binding]; other site 511145012801 ATP/Mg binding site [chemical binding]; other site 511145012802 stacking interactions; other site 511145012803 hinge regions; other site 511145012804 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 511145012805 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 511145012806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145012807 FeS/SAM binding site; other site 511145012808 elongation factor P; Validated; Region: PRK00529 511145012809 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 511145012810 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 511145012811 RNA binding site [nucleotide binding]; other site 511145012812 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 511145012813 RNA binding site [nucleotide binding]; other site 511145012814 entericidin A; Provisional; Region: PRK09810 511145012815 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 511145012816 multidrug efflux system protein; Provisional; Region: PRK11431 511145012817 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 511145012818 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 511145012819 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 511145012820 Iron-sulfur protein interface; other site 511145012821 proximal quinone binding site [chemical binding]; other site 511145012822 C-subunit interface; other site 511145012823 distal quinone binding site; other site 511145012824 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 511145012825 D-subunit interface [polypeptide binding]; other site 511145012826 Iron-sulfur protein interface; other site 511145012827 proximal quinone binding site [chemical binding]; other site 511145012828 distal quinone binding site [chemical binding]; other site 511145012829 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 511145012830 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 511145012831 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 511145012832 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 511145012833 L-aspartate oxidase; Provisional; Region: PRK06175 511145012834 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 511145012835 poxB regulator PoxA; Provisional; Region: PRK09350 511145012836 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511145012837 motif 1; other site 511145012838 dimer interface [polypeptide binding]; other site 511145012839 active site 511145012840 motif 2; other site 511145012841 motif 3; other site 511145012842 inner membrane transporter YjeM; Provisional; Region: PRK15238 511145012843 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 511145012844 putative mechanosensitive channel protein; Provisional; Region: PRK10929 511145012845 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 511145012846 DNA-binding site [nucleotide binding]; DNA binding site 511145012847 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 511145012848 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 511145012849 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511145012850 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 511145012851 GTPase RsgA; Reviewed; Region: PRK12288 511145012852 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511145012853 RNA binding site [nucleotide binding]; other site 511145012854 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 511145012855 GTPase/Zn-binding domain interface [polypeptide binding]; other site 511145012856 GTP/Mg2+ binding site [chemical binding]; other site 511145012857 G4 box; other site 511145012858 G5 box; other site 511145012859 G1 box; other site 511145012860 Switch I region; other site 511145012861 G2 box; other site 511145012862 G3 box; other site 511145012863 Switch II region; other site 511145012864 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 511145012865 catalytic site [active] 511145012866 putative active site [active] 511145012867 putative substrate binding site [chemical binding]; other site 511145012868 dimer interface [polypeptide binding]; other site 511145012869 epoxyqueuosine reductase; Region: TIGR00276 511145012870 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 511145012871 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 511145012872 putative carbohydrate kinase; Provisional; Region: PRK10565 511145012873 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 511145012874 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 511145012875 putative substrate binding site [chemical binding]; other site 511145012876 putative ATP binding site [chemical binding]; other site 511145012877 ADP-binding protein; Provisional; Region: PRK10646 511145012878 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 511145012879 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 511145012880 AMIN domain; Region: AMIN; pfam11741 511145012881 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511145012882 active site 511145012883 metal binding site [ion binding]; metal-binding site 511145012884 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 511145012885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145012886 ATP binding site [chemical binding]; other site 511145012887 Mg2+ binding site [ion binding]; other site 511145012888 G-X-G motif; other site 511145012889 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 511145012890 ATP binding site [chemical binding]; other site 511145012891 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 511145012892 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 511145012893 bacterial Hfq-like; Region: Hfq; cd01716 511145012894 hexamer interface [polypeptide binding]; other site 511145012895 Sm1 motif; other site 511145012896 RNA binding site [nucleotide binding]; other site 511145012897 Sm2 motif; other site 511145012898 GTPase HflX; Provisional; Region: PRK11058 511145012899 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 511145012900 HflX GTPase family; Region: HflX; cd01878 511145012901 G1 box; other site 511145012902 GTP/Mg2+ binding site [chemical binding]; other site 511145012903 Switch I region; other site 511145012904 G2 box; other site 511145012905 G3 box; other site 511145012906 Switch II region; other site 511145012907 G4 box; other site 511145012908 G5 box; other site 511145012909 FtsH protease regulator HflK; Provisional; Region: PRK10930 511145012910 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 511145012911 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 511145012912 HflC protein; Region: hflC; TIGR01932 511145012913 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 511145012914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 511145012915 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 511145012916 GDP-binding site [chemical binding]; other site 511145012917 ACT binding site; other site 511145012918 IMP binding site; other site 511145012919 transcriptional repressor NsrR; Provisional; Region: PRK11014 511145012920 Rrf2 family protein; Region: rrf2_super; TIGR00738 511145012921 exoribonuclease R; Provisional; Region: PRK11642 511145012922 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 511145012923 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 511145012924 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 511145012925 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 511145012926 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 511145012927 RNA binding site [nucleotide binding]; other site 511145012928 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 511145012929 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 511145012930 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511145012931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 511145012932 PspA/IM30 family; Region: PspA_IM30; pfam04012 511145012933 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 511145012934 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 511145012935 Predicted membrane protein [Function unknown]; Region: COG3766 511145012936 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 511145012937 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 511145012938 Predicted integral membrane protein [Function unknown]; Region: COG5463 511145012939 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 511145012940 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 511145012941 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 511145012942 FAD binding site [chemical binding]; other site 511145012943 substrate binding site [chemical binding]; other site 511145012944 catalytic residues [active] 511145012945 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 511145012946 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 511145012947 esterase; Provisional; Region: PRK10566 511145012948 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511145012949 transcriptional repressor UlaR; Provisional; Region: PRK13509 511145012950 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 511145012951 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145012952 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 511145012953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 511145012954 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 511145012955 active site 511145012956 P-loop; other site 511145012957 phosphorylation site [posttranslational modification] 511145012958 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145012959 active site 511145012960 phosphorylation site [posttranslational modification] 511145012961 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 511145012962 active site 511145012963 dimer interface [polypeptide binding]; other site 511145012964 magnesium binding site [ion binding]; other site 511145012965 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 511145012966 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 511145012967 AP (apurinic/apyrimidinic) site pocket; other site 511145012968 DNA interaction; other site 511145012969 Metal-binding active site; metal-binding site 511145012970 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 511145012971 intersubunit interface [polypeptide binding]; other site 511145012972 active site 511145012973 Zn2+ binding site [ion binding]; other site 511145012974 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 511145012975 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 511145012976 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 511145012977 dimer interface [polypeptide binding]; other site 511145012978 ssDNA binding site [nucleotide binding]; other site 511145012979 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511145012980 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 511145012981 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 511145012982 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 511145012983 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 511145012984 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 511145012985 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 511145012986 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 511145012987 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 511145012988 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 511145012989 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 511145012990 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 511145012991 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 511145012992 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 511145012993 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 511145012994 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 511145012995 Hemerythrin-like domain; Region: Hr-like; cd12108 511145012996 Fe binding site [ion binding]; other site 511145012997 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 511145012998 EamA-like transporter family; Region: EamA; pfam00892 511145012999 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 511145013000 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 511145013001 NADP binding site [chemical binding]; other site 511145013002 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 511145013003 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 511145013004 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 511145013005 active site 511145013006 metal binding site [ion binding]; metal-binding site 511145013007 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511145013008 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 511145013009 active site 511145013010 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 511145013011 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 511145013012 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 511145013013 Domain of unknown function DUF21; Region: DUF21; pfam01595 511145013014 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511145013015 Transporter associated domain; Region: CorC_HlyC; smart01091 511145013016 methionine sulfoxide reductase A; Provisional; Region: PRK00058 511145013017 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 511145013018 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 511145013019 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 511145013020 Surface antigen; Region: Bac_surface_Ag; pfam01103 511145013021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 511145013022 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 511145013023 Family of unknown function (DUF490); Region: DUF490; pfam04357 511145013024 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 511145013025 putative active site pocket [active] 511145013026 dimerization interface [polypeptide binding]; other site 511145013027 putative catalytic residue [active] 511145013028 antitoxin ChpS; Provisional; Region: PRK11347 511145013029 toxin ChpB; Provisional; Region: PRK09812 511145013030 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 511145013031 dimer interface [polypeptide binding]; other site 511145013032 substrate binding site [chemical binding]; other site 511145013033 metal binding sites [ion binding]; metal-binding site 511145013034 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 511145013035 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 511145013036 putative ligand binding site [chemical binding]; other site 511145013037 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 511145013038 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511145013039 Walker A/P-loop; other site 511145013040 ATP binding site [chemical binding]; other site 511145013041 Q-loop/lid; other site 511145013042 ABC transporter signature motif; other site 511145013043 Walker B; other site 511145013044 D-loop; other site 511145013045 H-loop/switch region; other site 511145013046 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511145013047 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145013048 TM-ABC transporter signature motif; other site 511145013049 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 511145013050 TM-ABC transporter signature motif; other site 511145013051 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 511145013052 AMP binding site [chemical binding]; other site 511145013053 metal binding site [ion binding]; metal-binding site 511145013054 active site 511145013055 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 511145013056 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511145013057 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511145013058 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511145013059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 511145013060 peptidase PmbA; Provisional; Region: PRK11040 511145013061 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 511145013062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145013063 FeS/SAM binding site; other site 511145013064 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 511145013065 ATP cone domain; Region: ATP-cone; pfam03477 511145013066 Class III ribonucleotide reductase; Region: RNR_III; cd01675 511145013067 effector binding site; other site 511145013068 active site 511145013069 Zn binding site [ion binding]; other site 511145013070 glycine loop; other site 511145013071 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 511145013072 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 511145013073 Ca binding site [ion binding]; other site 511145013074 active site 511145013075 catalytic site [active] 511145013076 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 511145013077 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 511145013078 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511145013079 active site turn [active] 511145013080 phosphorylation site [posttranslational modification] 511145013081 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511145013082 trehalose repressor; Provisional; Region: treR; PRK09492 511145013083 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145013084 DNA binding site [nucleotide binding] 511145013085 domain linker motif; other site 511145013086 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 511145013087 dimerization interface [polypeptide binding]; other site 511145013088 ligand binding site [chemical binding]; other site 511145013089 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 511145013090 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 511145013091 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511145013092 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511145013093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145013094 motif II; other site 511145013095 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511145013096 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 511145013097 homotrimer interaction site [polypeptide binding]; other site 511145013098 putative active site [active] 511145013099 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 511145013100 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 511145013101 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 511145013102 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 511145013103 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511145013104 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511145013105 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 511145013106 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 511145013107 homotrimer interaction site [polypeptide binding]; other site 511145013108 putative active site [active] 511145013109 oxidoreductase; Provisional; Region: PRK12742 511145013110 classical (c) SDRs; Region: SDR_c; cd05233 511145013111 NAD(P) binding site [chemical binding]; other site 511145013112 active site 511145013113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511145013114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511145013115 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 511145013116 SopA-like central domain; Region: SopA; pfam13981 511145013117 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 511145013118 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511145013119 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511145013120 RNase E inhibitor protein; Provisional; Region: PRK11191 511145013121 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511145013122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145013123 Coenzyme A binding pocket [chemical binding]; other site 511145013124 Predicted membrane protein [Function unknown]; Region: COG4269 511145013125 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 511145013126 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 511145013127 active site 511145013128 HIGH motif; other site 511145013129 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511145013130 KMSKS motif; other site 511145013131 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 511145013132 tRNA binding surface [nucleotide binding]; other site 511145013133 anticodon binding site; other site 511145013134 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 511145013135 DNA polymerase III subunit chi; Validated; Region: PRK05728 511145013136 multifunctional aminopeptidase A; Provisional; Region: PRK00913 511145013137 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 511145013138 interface (dimer of trimers) [polypeptide binding]; other site 511145013139 Substrate-binding/catalytic site; other site 511145013140 Zn-binding sites [ion binding]; other site 511145013141 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 511145013142 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 511145013143 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 511145013144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145013145 Walker A motif; other site 511145013146 ATP binding site [chemical binding]; other site 511145013147 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 511145013148 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511145013149 DNA binding site [nucleotide binding] 511145013150 domain linker motif; other site 511145013151 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 511145013152 putative dimerization interface [polypeptide binding]; other site 511145013153 putative ligand binding site [chemical binding]; other site 511145013154 gluconate transporter; Region: gntP; TIGR00791 511145013155 GntP family permease; Region: GntP_permease; pfam02447 511145013156 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 511145013157 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 511145013158 NADP binding site [chemical binding]; other site 511145013159 homodimer interface [polypeptide binding]; other site 511145013160 active site 511145013161 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 511145013162 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 511145013163 putative NAD(P) binding site [chemical binding]; other site 511145013164 catalytic Zn binding site [ion binding]; other site 511145013165 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 511145013166 AAA domain; Region: AAA_33; pfam13671 511145013167 ATP-binding site [chemical binding]; other site 511145013168 Gluconate-6-phosphate binding site [chemical binding]; other site 511145013169 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 511145013170 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 511145013171 putative NAD(P) binding site [chemical binding]; other site 511145013172 putative substrate binding site [chemical binding]; other site 511145013173 catalytic Zn binding site [ion binding]; other site 511145013174 structural Zn binding site [ion binding]; other site 511145013175 dimer interface [polypeptide binding]; other site 511145013176 IS2 repressor TnpA; Reviewed; Region: PRK09413 511145013177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511145013178 IS2 transposase TnpB; Reviewed; Region: PRK09409 511145013179 HTH-like domain; Region: HTH_21; pfam13276 511145013180 Integrase core domain; Region: rve; pfam00665 511145013181 Integrase core domain; Region: rve_3; pfam13683 511145013182 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 511145013183 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 511145013184 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 511145013185 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511145013186 putative sialic acid transporter; Provisional; Region: PRK12307 511145013187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145013188 putative substrate translocation pore; other site 511145013189 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 511145013190 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 511145013191 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 511145013192 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511145013193 Helix-turn-helix domain; Region: HTH_38; pfam13936 511145013194 Homeodomain-like domain; Region: HTH_32; pfam13565 511145013195 Integrase core domain; Region: rve; pfam00665 511145013196 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 511145013197 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511145013198 Walker A/P-loop; other site 511145013199 ATP binding site [chemical binding]; other site 511145013200 Q-loop/lid; other site 511145013201 ABC transporter signature motif; other site 511145013202 Walker B; other site 511145013203 D-loop; other site 511145013204 H-loop/switch region; other site 511145013205 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511145013206 ABC-ATPase subunit interface; other site 511145013207 dimer interface [polypeptide binding]; other site 511145013208 putative PBP binding regions; other site 511145013209 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511145013210 ABC-ATPase subunit interface; other site 511145013211 dimer interface [polypeptide binding]; other site 511145013212 putative PBP binding regions; other site 511145013213 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 511145013214 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 511145013215 siderophore binding site; other site 511145013216 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 511145013217 Secretin and TonB N terminus short domain; Region: STN; smart00965 511145013218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 511145013219 N-terminal plug; other site 511145013220 ligand-binding site [chemical binding]; other site 511145013221 fec operon regulator FecR; Reviewed; Region: PRK09774 511145013222 FecR protein; Region: FecR; pfam04773 511145013223 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 511145013224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511145013225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511145013226 DNA binding residues [nucleotide binding] 511145013227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 511145013228 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 511145013229 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 511145013230 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 511145013231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 511145013232 DNA binding residues [nucleotide binding] 511145013233 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 511145013234 gluconate transporter; Region: gntP; TIGR00791 511145013235 GntP family permease; Region: GntP_permease; pfam02447 511145013236 putative dehydratase; Provisional; Region: PRK08211 511145013237 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 511145013238 inhibitor site; inhibition site 511145013239 active site 511145013240 dimer interface [polypeptide binding]; other site 511145013241 catalytic residue [active] 511145013242 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 511145013243 Transcriptional regulator [Transcription]; Region: IclR; COG1414 511145013244 Bacterial transcriptional regulator; Region: IclR; pfam01614 511145013245 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511145013246 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 511145013247 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511145013248 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 511145013249 substrate binding site [chemical binding]; other site 511145013250 hexamer interface [polypeptide binding]; other site 511145013251 metal binding site [ion binding]; metal-binding site 511145013252 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511145013253 active site 511145013254 phosphorylation site [posttranslational modification] 511145013255 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 511145013256 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 511145013257 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 511145013258 active site 511145013259 P-loop; other site 511145013260 phosphorylation site [posttranslational modification] 511145013261 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511145013262 oligomer interface [polypeptide binding]; other site 511145013263 active site 511145013264 metal binding site [ion binding]; metal-binding site 511145013265 Methyltransferase domain; Region: Methyltransf_31; pfam13847 511145013266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145013267 S-adenosylmethionine binding site [chemical binding]; other site 511145013268 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 511145013269 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 511145013270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145013271 Coenzyme A binding pocket [chemical binding]; other site 511145013272 hypothetical protein; Provisional; Region: PRK13687 511145013273 Domain of unknown function (DUF303); Region: DUF303; pfam03629 511145013274 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 511145013275 Kelch motif; Region: Kelch_1; pfam01344 511145013276 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 511145013277 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 511145013278 Int/Topo IB signature motif; other site 511145013279 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 511145013280 Int/Topo IB signature motif; other site 511145013281 Fimbrial protein; Region: Fimbrial; cl01416 511145013282 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 511145013283 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 511145013284 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 511145013285 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 511145013286 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 511145013287 PapC N-terminal domain; Region: PapC_N; pfam13954 511145013288 Outer membrane usher protein; Region: Usher; pfam00577 511145013289 PapC C-terminal domain; Region: PapC_C; pfam13953 511145013290 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 511145013291 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 511145013292 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 511145013293 mannosyl binding site [chemical binding]; other site 511145013294 Fimbrial protein; Region: Fimbrial; pfam00419 511145013295 fructuronate transporter; Provisional; Region: PRK10034 511145013296 GntP family permease; Region: GntP_permease; pfam02447 511145013297 mannonate dehydratase; Region: uxuA; TIGR00695 511145013298 mannonate dehydratase; Provisional; Region: PRK03906 511145013299 D-mannonate oxidoreductase; Provisional; Region: PRK15037 511145013300 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 511145013301 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 511145013302 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 511145013303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145013304 DNA-binding site [nucleotide binding]; DNA binding site 511145013305 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 511145013306 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 511145013307 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 511145013308 cell density-dependent motility repressor; Provisional; Region: PRK10082 511145013309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511145013310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511145013311 dimerization interface [polypeptide binding]; other site 511145013312 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 511145013313 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 511145013314 dimer interface [polypeptide binding]; other site 511145013315 active site 511145013316 hypothetical protein; Provisional; Region: PRK10519 511145013317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 511145013318 Nucleoside recognition; Region: Gate; pfam07670 511145013319 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 511145013320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145013321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511145013322 putative substrate translocation pore; other site 511145013323 SdiA-regulated; Region: SdiA-regulated; cd09971 511145013324 putative active site [active] 511145013325 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 511145013326 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 511145013327 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 511145013328 Predicted membrane protein [Function unknown]; Region: COG2733 511145013329 Protein of unknown function (DUF445); Region: DUF445; pfam04286 511145013330 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 511145013331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145013332 putative substrate translocation pore; other site 511145013333 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 511145013334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511145013335 DNA-binding site [nucleotide binding]; DNA binding site 511145013336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511145013337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511145013338 homodimer interface [polypeptide binding]; other site 511145013339 catalytic residue [active] 511145013340 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 511145013341 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 511145013342 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 511145013343 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 511145013344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145013345 Walker A motif; other site 511145013346 ATP binding site [chemical binding]; other site 511145013347 Walker B motif; other site 511145013348 arginine finger; other site 511145013349 endoribonuclease SymE; Provisional; Region: PRK13605 511145013350 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 511145013351 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 511145013352 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 511145013353 HsdM N-terminal domain; Region: HsdM_N; pfam12161 511145013354 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 511145013355 Methyltransferase domain; Region: Methyltransf_26; pfam13659 511145013356 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 511145013357 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 511145013358 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 511145013359 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 511145013360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511145013361 ATP binding site [chemical binding]; other site 511145013362 putative Mg++ binding site [ion binding]; other site 511145013363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511145013364 nucleotide binding region [chemical binding]; other site 511145013365 ATP-binding site [chemical binding]; other site 511145013366 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 511145013367 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 511145013368 Mrr N-terminal domain; Region: Mrr_N; pfam14338 511145013369 Restriction endonuclease; Region: Mrr_cat; pfam04471 511145013370 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 511145013371 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 511145013372 P-loop, Walker A motif; other site 511145013373 Base recognition motif; other site 511145013374 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 511145013375 Uncharacterized small protein [Function unknown]; Region: COG2879 511145013376 carbon starvation protein A; Provisional; Region: PRK15015 511145013377 Carbon starvation protein CstA; Region: CstA; pfam02554 511145013378 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 511145013379 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 511145013380 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 511145013381 dimer interface [polypeptide binding]; other site 511145013382 ligand binding site [chemical binding]; other site 511145013383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145013384 dimerization interface [polypeptide binding]; other site 511145013385 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 511145013386 dimer interface [polypeptide binding]; other site 511145013387 putative CheW interface [polypeptide binding]; other site 511145013388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511145013389 D-galactonate transporter; Region: 2A0114; TIGR00893 511145013390 putative substrate translocation pore; other site 511145013391 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511145013392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 511145013393 DNA-binding site [nucleotide binding]; DNA binding site 511145013394 Transcriptional regulators [Transcription]; Region: GntR; COG1802 511145013395 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 511145013396 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511145013397 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 511145013398 putative NAD(P) binding site [chemical binding]; other site 511145013399 catalytic Zn binding site [ion binding]; other site 511145013400 structural Zn binding site [ion binding]; other site 511145013401 phosphoglycerol transferase I; Provisional; Region: PRK03776 511145013402 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 511145013403 hypothetical protein; Provisional; Region: PRK11667 511145013404 DNA replication protein DnaC; Validated; Region: PRK07952 511145013405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511145013406 Walker A motif; other site 511145013407 ATP binding site [chemical binding]; other site 511145013408 Walker B motif; other site 511145013409 primosomal protein DnaI; Provisional; Region: PRK02854 511145013410 hypothetical protein; Provisional; Region: PRK09917 511145013411 Uncharacterized conserved protein [Function unknown]; Region: COG2966 511145013412 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 511145013413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 511145013414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145013415 DNA binding residues [nucleotide binding] 511145013416 dimerization interface [polypeptide binding]; other site 511145013417 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 511145013418 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511145013419 DNA binding residues [nucleotide binding] 511145013420 dimerization interface [polypeptide binding]; other site 511145013421 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 511145013422 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 511145013423 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 511145013424 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 511145013425 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 511145013426 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 511145013427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511145013428 S-adenosylmethionine binding site [chemical binding]; other site 511145013429 DNA polymerase III subunit psi; Validated; Region: PRK06856 511145013430 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 511145013431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511145013432 Coenzyme A binding pocket [chemical binding]; other site 511145013433 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 511145013434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145013435 motif II; other site 511145013436 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 511145013437 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 511145013438 G1 box; other site 511145013439 putative GEF interaction site [polypeptide binding]; other site 511145013440 GTP/Mg2+ binding site [chemical binding]; other site 511145013441 Switch I region; other site 511145013442 G2 box; other site 511145013443 G3 box; other site 511145013444 Switch II region; other site 511145013445 G4 box; other site 511145013446 G5 box; other site 511145013447 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 511145013448 Elongation Factor G, domain II; Region: EFG_II; pfam14492 511145013449 periplasmic protein; Provisional; Region: PRK10568 511145013450 BON domain; Region: BON; pfam04972 511145013451 BON domain; Region: BON; pfam04972 511145013452 Small integral membrane protein [Function unknown]; Region: COG5487 511145013453 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 511145013454 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 511145013455 active site 511145013456 nucleophile elbow; other site 511145013457 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 511145013458 active site 511145013459 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 511145013460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511145013461 FeS/SAM binding site; other site 511145013462 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 511145013463 hypothetical protein; Provisional; Region: PRK10977 511145013464 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 511145013465 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 511145013466 intersubunit interface [polypeptide binding]; other site 511145013467 active site 511145013468 catalytic residue [active] 511145013469 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 511145013470 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511145013471 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511145013472 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 511145013473 phosphopentomutase; Provisional; Region: PRK05362 511145013474 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 511145013475 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 511145013476 HipA-like N-terminal domain; Region: HipA_N; pfam07805 511145013477 HipA-like C-terminal domain; Region: HipA_C; pfam07804 511145013478 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 511145013479 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511145013480 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 511145013481 hypothetical protein; Provisional; Region: PRK11246 511145013482 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 511145013483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511145013484 motif II; other site 511145013485 DNA repair protein RadA; Region: sms; TIGR00416 511145013486 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 511145013487 Walker A motif/ATP binding site; other site 511145013488 ATP binding site [chemical binding]; other site 511145013489 Walker B motif; other site 511145013490 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 511145013491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511145013492 non-specific DNA binding site [nucleotide binding]; other site 511145013493 salt bridge; other site 511145013494 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 511145013495 sequence-specific DNA binding site [nucleotide binding]; other site 511145013496 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 511145013497 active site 511145013498 (T/H)XGH motif; other site 511145013499 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 511145013500 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 511145013501 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511145013502 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 511145013503 ABC transporter; Region: ABC_tran_2; pfam12848 511145013504 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511145013505 lytic murein transglycosylase; Provisional; Region: PRK11619 511145013506 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 511145013507 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 511145013508 N-acetyl-D-glucosamine binding site [chemical binding]; other site 511145013509 catalytic residue [active] 511145013510 Trp operon repressor [Transcription]; Region: TrpR; COG2973 511145013511 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 511145013512 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511145013513 catalytic core [active] 511145013514 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 511145013515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145013516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511145013517 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 511145013518 hypothetical protein; Provisional; Region: PRK10756 511145013519 DNA-binding response regulator CreB; Provisional; Region: PRK11083 511145013520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145013521 active site 511145013522 phosphorylation site [posttranslational modification] 511145013523 intermolecular recognition site; other site 511145013524 dimerization interface [polypeptide binding]; other site 511145013525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145013526 DNA binding site [nucleotide binding] 511145013527 sensory histidine kinase CreC; Provisional; Region: PRK11100 511145013528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511145013529 dimerization interface [polypeptide binding]; other site 511145013530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511145013531 dimer interface [polypeptide binding]; other site 511145013532 phosphorylation site [posttranslational modification] 511145013533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511145013534 ATP binding site [chemical binding]; other site 511145013535 Mg2+ binding site [ion binding]; other site 511145013536 G-X-G motif; other site 511145013537 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 511145013538 two-component response regulator; Provisional; Region: PRK11173 511145013539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511145013540 active site 511145013541 phosphorylation site [posttranslational modification] 511145013542 intermolecular recognition site; other site 511145013543 dimerization interface [polypeptide binding]; other site 511145013544 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511145013545 DNA binding site [nucleotide binding] 511145013546 putative RNA methyltransferase; Provisional; Region: PRK10433 511145013547 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050