-- dump date   	20140618_223456
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
224308000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
224308000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
224308000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308000004	Walker A motif; other site
224308000005	ATP binding site [chemical binding]; other site
224308000006	Walker B motif; other site
224308000007	arginine finger; other site
224308000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
224308000009	DnaA box-binding interface [nucleotide binding]; other site
224308000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
224308000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
224308000012	putative DNA binding surface [nucleotide binding]; other site
224308000013	dimer interface [polypeptide binding]; other site
224308000014	beta-clamp/clamp loader binding surface; other site
224308000015	beta-clamp/translesion DNA polymerase binding surface; other site
224308000016	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
224308000017	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
224308000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
224308000019	Walker A/P-loop; other site
224308000020	ATP binding site [chemical binding]; other site
224308000021	Q-loop/lid; other site
224308000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224308000023	ABC transporter signature motif; other site
224308000024	Walker B; other site
224308000025	D-loop; other site
224308000026	H-loop/switch region; other site
224308000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
224308000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308000029	ATP binding site [chemical binding]; other site
224308000030	Mg2+ binding site [ion binding]; other site
224308000031	G-X-G motif; other site
224308000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
224308000033	anchoring element; other site
224308000034	dimer interface [polypeptide binding]; other site
224308000035	ATP binding site [chemical binding]; other site
224308000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
224308000037	active site
224308000038	putative metal-binding site [ion binding]; other site
224308000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
224308000040	DNA gyrase subunit A; Validated; Region: PRK05560
224308000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
224308000042	CAP-like domain; other site
224308000043	active site
224308000044	primary dimer interface [polypeptide binding]; other site
224308000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308000051	YaaC-like Protein; Region: YaaC; pfam14175
224308000052	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
224308000053	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
224308000054	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
224308000055	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
224308000056	active site
224308000057	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
224308000058	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
224308000059	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
224308000060	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
224308000061	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
224308000062	active site
224308000063	multimer interface [polypeptide binding]; other site
224308000064	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
224308000065	Glutamine amidotransferase class-I; Region: GATase; pfam00117
224308000066	predicted active site [active]
224308000067	catalytic triad [active]
224308000068	seryl-tRNA synthetase; Provisional; Region: PRK05431
224308000069	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
224308000070	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
224308000071	dimer interface [polypeptide binding]; other site
224308000072	active site
224308000073	motif 1; other site
224308000074	motif 2; other site
224308000075	motif 3; other site
224308000076	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
224308000077	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
224308000078	Substrate-binding site [chemical binding]; other site
224308000079	Substrate specificity [chemical binding]; other site
224308000080	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
224308000081	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
224308000082	Substrate-binding site [chemical binding]; other site
224308000083	Substrate specificity [chemical binding]; other site
224308000084	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
224308000085	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308000086	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308000087	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
224308000088	active site
224308000089	Isochorismatase family; Region: Isochorismatase; pfam00857
224308000090	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
224308000091	catalytic triad [active]
224308000092	conserved cis-peptide bond; other site
224308000093	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
224308000094	nucleoside/Zn binding site; other site
224308000095	dimer interface [polypeptide binding]; other site
224308000096	catalytic motif [active]
224308000097	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
224308000098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308000099	Walker A motif; other site
224308000100	ATP binding site [chemical binding]; other site
224308000101	Walker B motif; other site
224308000102	arginine finger; other site
224308000103	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
224308000104	hypothetical protein; Validated; Region: PRK00153
224308000105	recombination protein RecR; Reviewed; Region: recR; PRK00076
224308000106	RecR protein; Region: RecR; pfam02132
224308000107	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
224308000108	putative active site [active]
224308000109	putative metal-binding site [ion binding]; other site
224308000110	tetramer interface [polypeptide binding]; other site
224308000111	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
224308000112	pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862
224308000113	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
224308000114	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
224308000115	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
224308000116	Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276
224308000117	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
224308000118	homodimer interface [polypeptide binding]; other site
224308000119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308000120	catalytic residue [active]
224308000121	thymidylate kinase; Validated; Region: tmk; PRK00698
224308000122	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
224308000123	TMP-binding site; other site
224308000124	ATP-binding site [chemical binding]; other site
224308000125	Protein of unknown function (DUF970); Region: DUF970; pfam06153
224308000126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728
224308000127	DNA polymerase III subunit delta'; Validated; Region: PRK08058
224308000128	DNA polymerase III subunit delta'; Validated; Region: PRK08485
224308000129	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
224308000130	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
224308000131	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
224308000132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308000133	S-adenosylmethionine binding site [chemical binding]; other site
224308000134	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
224308000135	GIY-YIG motif/motif A; other site
224308000136	putative active site [active]
224308000137	putative metal binding site [ion binding]; other site
224308000138	Predicted methyltransferases [General function prediction only]; Region: COG0313
224308000139	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
224308000140	putative SAM binding site [chemical binding]; other site
224308000141	putative homodimer interface [polypeptide binding]; other site
224308000142	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
224308000143	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
224308000144	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
224308000145	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
224308000146	active site
224308000147	HIGH motif; other site
224308000148	KMSKS motif; other site
224308000149	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
224308000150	tRNA binding surface [nucleotide binding]; other site
224308000151	anticodon binding site; other site
224308000152	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
224308000153	dimer interface [polypeptide binding]; other site
224308000154	putative tRNA-binding site [nucleotide binding]; other site
224308000155	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
224308000156	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
224308000157	active site
224308000158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
224308000159	Domain of unknown function (DUF348); Region: DUF348; pfam03990
224308000160	Domain of unknown function (DUF348); Region: DUF348; pfam03990
224308000161	Domain of unknown function (DUF348); Region: DUF348; pfam03990
224308000162	G5 domain; Region: G5; pfam07501
224308000163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
224308000164	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
224308000165	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
224308000166	putative active site [active]
224308000167	putative metal binding site [ion binding]; other site
224308000168	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
224308000169	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
224308000170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308000171	S-adenosylmethionine binding site [chemical binding]; other site
224308000172	sporulation peptidase YabG; Region: spore_yabG; TIGR02855
224308000173	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
224308000174	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
224308000175	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
224308000176	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
224308000177	pur operon repressor; Provisional; Region: PRK09213
224308000178	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
224308000179	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308000180	active site
224308000181	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
224308000182	homotrimer interaction site [polypeptide binding]; other site
224308000183	putative active site [active]
224308000184	regulatory protein SpoVG; Reviewed; Region: PRK13259
224308000185	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
224308000186	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
224308000187	Substrate binding site; other site
224308000188	Mg++ binding site; other site
224308000189	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
224308000190	active site
224308000191	substrate binding site [chemical binding]; other site
224308000192	CoA binding site [chemical binding]; other site
224308000193	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
224308000194	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
224308000195	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308000196	active site
224308000197	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
224308000198	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
224308000199	5S rRNA interface [nucleotide binding]; other site
224308000200	CTC domain interface [polypeptide binding]; other site
224308000201	L16 interface [polypeptide binding]; other site
224308000202	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
224308000203	putative active site [active]
224308000204	catalytic residue [active]
224308000205	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
224308000206	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
224308000207	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
224308000208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308000209	ATP binding site [chemical binding]; other site
224308000210	putative Mg++ binding site [ion binding]; other site
224308000211	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308000212	nucleotide binding region [chemical binding]; other site
224308000213	ATP-binding site [chemical binding]; other site
224308000214	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
224308000215	stage V sporulation protein T; Region: spore_V_T; TIGR02851
224308000216	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
224308000217	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
224308000218	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
224308000219	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
224308000220	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
224308000221	putative SAM binding site [chemical binding]; other site
224308000222	putative homodimer interface [polypeptide binding]; other site
224308000223	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
224308000224	homodimer interface [polypeptide binding]; other site
224308000225	metal binding site [ion binding]; metal-binding site
224308000226	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
224308000227	homodimer interface [polypeptide binding]; other site
224308000228	active site
224308000229	putative chemical substrate binding site [chemical binding]; other site
224308000230	metal binding site [ion binding]; metal-binding site
224308000231	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308000232	RNA binding surface [nucleotide binding]; other site
224308000233	sporulation protein YabP; Region: spore_yabP; TIGR02892
224308000234	spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893
224308000235	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
224308000236	Septum formation initiator; Region: DivIC; pfam04977
224308000237	hypothetical protein; Provisional; Region: PRK08582
224308000238	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
224308000239	RNA binding site [nucleotide binding]; other site
224308000240	stage II sporulation protein E; Region: spore_II_E; TIGR02865
224308000241	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
224308000242	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
224308000243	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
224308000244	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
224308000245	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
224308000246	metal ion-dependent adhesion site (MIDAS); other site
224308000247	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
224308000248	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
224308000249	active site
224308000250	ATP binding site [chemical binding]; other site
224308000251	substrate binding site [chemical binding]; other site
224308000252	activation loop (A-loop); other site
224308000253	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
224308000254	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
224308000255	Ligand Binding Site [chemical binding]; other site
224308000256	TilS substrate binding domain; Region: TilS; pfam09179
224308000257	TilS substrate C-terminal domain; Region: TilS_C; smart00977
224308000258	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308000259	active site
224308000260	FtsH Extracellular; Region: FtsH_ext; pfam06480
224308000261	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
224308000262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308000263	Walker A motif; other site
224308000264	ATP binding site [chemical binding]; other site
224308000265	Walker B motif; other site
224308000266	arginine finger; other site
224308000267	Peptidase family M41; Region: Peptidase_M41; pfam01434
224308000268	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224308000269	nucleotide binding site [chemical binding]; other site
224308000270	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
224308000271	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
224308000272	dimerization interface [polypeptide binding]; other site
224308000273	domain crossover interface; other site
224308000274	redox-dependent activation switch; other site
224308000275	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
224308000276	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
224308000277	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
224308000278	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
224308000279	dimer interface [polypeptide binding]; other site
224308000280	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308000281	catalytic residue [active]
224308000282	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
224308000283	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
224308000284	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
224308000285	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
224308000286	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
224308000287	glutamine binding [chemical binding]; other site
224308000288	catalytic triad [active]
224308000289	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
224308000290	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
224308000291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308000292	catalytic residue [active]
224308000293	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
224308000294	dihydropteroate synthase; Region: DHPS; TIGR01496
224308000295	substrate binding pocket [chemical binding]; other site
224308000296	dimer interface [polypeptide binding]; other site
224308000297	inhibitor binding site; inhibition site
224308000298	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
224308000299	homooctamer interface [polypeptide binding]; other site
224308000300	active site
224308000301	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
224308000302	catalytic center binding site [active]
224308000303	ATP binding site [chemical binding]; other site
224308000304	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308000305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308000306	non-specific DNA binding site [nucleotide binding]; other site
224308000307	salt bridge; other site
224308000308	sequence-specific DNA binding site [nucleotide binding]; other site
224308000309	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
224308000310	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
224308000311	FMN binding site [chemical binding]; other site
224308000312	active site
224308000313	catalytic residues [active]
224308000314	substrate binding site [chemical binding]; other site
224308000315	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
224308000316	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
224308000317	dimer interface [polypeptide binding]; other site
224308000318	putative anticodon binding site; other site
224308000319	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
224308000320	motif 1; other site
224308000321	active site
224308000322	motif 2; other site
224308000323	motif 3; other site
224308000324	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
224308000325	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
224308000326	UvrB/uvrC motif; Region: UVR; pfam02151
224308000327	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
224308000328	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
224308000329	ADP binding site [chemical binding]; other site
224308000330	phosphagen binding site; other site
224308000331	substrate specificity loop; other site
224308000332	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
224308000333	Clp amino terminal domain; Region: Clp_N; pfam02861
224308000334	Clp amino terminal domain; Region: Clp_N; pfam02861
224308000335	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308000336	Walker A motif; other site
224308000337	ATP binding site [chemical binding]; other site
224308000338	Walker B motif; other site
224308000339	arginine finger; other site
224308000340	UvrB/uvrC motif; Region: UVR; pfam02151
224308000341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308000342	Walker A motif; other site
224308000343	ATP binding site [chemical binding]; other site
224308000344	Walker B motif; other site
224308000345	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
224308000346	DNA repair protein RadA; Provisional; Region: PRK11823
224308000347	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
224308000348	Walker A motif/ATP binding site; other site
224308000349	ATP binding site [chemical binding]; other site
224308000350	Walker B motif; other site
224308000351	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
224308000352	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
224308000353	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
224308000354	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
224308000355	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
224308000356	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
224308000357	putative active site [active]
224308000358	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
224308000359	substrate binding site; other site
224308000360	dimer interface; other site
224308000361	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
224308000362	homotrimer interaction site [polypeptide binding]; other site
224308000363	zinc binding site [ion binding]; other site
224308000364	CDP-binding sites; other site
224308000365	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
224308000366	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
224308000367	active site
224308000368	HIGH motif; other site
224308000369	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
224308000370	active site
224308000371	KMSKS motif; other site
224308000372	serine O-acetyltransferase; Region: cysE; TIGR01172
224308000373	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
224308000374	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
224308000375	trimer interface [polypeptide binding]; other site
224308000376	active site
224308000377	substrate binding site [chemical binding]; other site
224308000378	CoA binding site [chemical binding]; other site
224308000379	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
224308000380	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
224308000381	active site
224308000382	HIGH motif; other site
224308000383	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
224308000384	KMSKS motif; other site
224308000385	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
224308000386	tRNA binding surface [nucleotide binding]; other site
224308000387	anticodon binding site; other site
224308000388	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
224308000389	active site
224308000390	metal binding site [ion binding]; metal-binding site
224308000391	dimerization interface [polypeptide binding]; other site
224308000392	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
224308000393	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
224308000394	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
224308000395	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
224308000396	RNA polymerase factor sigma-70; Validated; Region: PRK08295
224308000397	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308000398	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
224308000399	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
224308000400	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
224308000401	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
224308000402	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
224308000403	putative homodimer interface [polypeptide binding]; other site
224308000404	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
224308000405	heterodimer interface [polypeptide binding]; other site
224308000406	homodimer interface [polypeptide binding]; other site
224308000407	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
224308000408	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
224308000409	23S rRNA interface [nucleotide binding]; other site
224308000410	L7/L12 interface [polypeptide binding]; other site
224308000411	putative thiostrepton binding site; other site
224308000412	L25 interface [polypeptide binding]; other site
224308000413	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
224308000414	mRNA/rRNA interface [nucleotide binding]; other site
224308000415	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
224308000416	23S rRNA interface [nucleotide binding]; other site
224308000417	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
224308000418	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
224308000419	core dimer interface [polypeptide binding]; other site
224308000420	peripheral dimer interface [polypeptide binding]; other site
224308000421	L10 interface [polypeptide binding]; other site
224308000422	L11 interface [polypeptide binding]; other site
224308000423	putative EF-Tu interaction site [polypeptide binding]; other site
224308000424	putative EF-G interaction site [polypeptide binding]; other site
224308000425	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
224308000426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308000427	S-adenosylmethionine binding site [chemical binding]; other site
224308000428	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
224308000429	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
224308000430	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
224308000431	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
224308000432	RPB1 interaction site [polypeptide binding]; other site
224308000433	RPB10 interaction site [polypeptide binding]; other site
224308000434	RPB11 interaction site [polypeptide binding]; other site
224308000435	RPB3 interaction site [polypeptide binding]; other site
224308000436	RPB12 interaction site [polypeptide binding]; other site
224308000437	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
224308000438	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
224308000439	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
224308000440	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
224308000441	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
224308000442	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
224308000443	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
224308000444	G-loop; other site
224308000445	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
224308000446	DNA binding site [nucleotide binding]
224308000447	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
224308000448	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
224308000449	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
224308000450	S17 interaction site [polypeptide binding]; other site
224308000451	S8 interaction site; other site
224308000452	16S rRNA interaction site [nucleotide binding]; other site
224308000453	streptomycin interaction site [chemical binding]; other site
224308000454	23S rRNA interaction site [nucleotide binding]; other site
224308000455	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
224308000456	30S ribosomal protein S7; Validated; Region: PRK05302
224308000457	elongation factor G; Reviewed; Region: PRK00007
224308000458	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
224308000459	G1 box; other site
224308000460	putative GEF interaction site [polypeptide binding]; other site
224308000461	GTP/Mg2+ binding site [chemical binding]; other site
224308000462	Switch I region; other site
224308000463	G2 box; other site
224308000464	G3 box; other site
224308000465	Switch II region; other site
224308000466	G4 box; other site
224308000467	G5 box; other site
224308000468	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
224308000469	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
224308000470	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
224308000471	elongation factor Tu; Reviewed; Region: PRK00049
224308000472	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
224308000473	G1 box; other site
224308000474	GEF interaction site [polypeptide binding]; other site
224308000475	GTP/Mg2+ binding site [chemical binding]; other site
224308000476	Switch I region; other site
224308000477	G2 box; other site
224308000478	G3 box; other site
224308000479	Switch II region; other site
224308000480	G4 box; other site
224308000481	G5 box; other site
224308000482	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
224308000483	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
224308000484	Antibiotic Binding Site [chemical binding]; other site
224308000485	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308000486	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
224308000487	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
224308000488	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
224308000489	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
224308000490	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
224308000491	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
224308000492	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
224308000493	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
224308000494	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
224308000495	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
224308000496	putative translocon binding site; other site
224308000497	protein-rRNA interface [nucleotide binding]; other site
224308000498	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
224308000499	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
224308000500	G-X-X-G motif; other site
224308000501	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
224308000502	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
224308000503	23S rRNA interface [nucleotide binding]; other site
224308000504	5S rRNA interface [nucleotide binding]; other site
224308000505	putative antibiotic binding site [chemical binding]; other site
224308000506	L25 interface [polypeptide binding]; other site
224308000507	L27 interface [polypeptide binding]; other site
224308000508	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
224308000509	23S rRNA interface [nucleotide binding]; other site
224308000510	putative translocon interaction site; other site
224308000511	signal recognition particle (SRP54) interaction site; other site
224308000512	L23 interface [polypeptide binding]; other site
224308000513	trigger factor interaction site; other site
224308000514	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
224308000515	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
224308000516	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
224308000517	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
224308000518	RNA binding site [nucleotide binding]; other site
224308000519	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
224308000520	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
224308000521	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
224308000522	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
224308000523	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
224308000524	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
224308000525	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
224308000526	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
224308000527	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
224308000528	5S rRNA interface [nucleotide binding]; other site
224308000529	L27 interface [polypeptide binding]; other site
224308000530	23S rRNA interface [nucleotide binding]; other site
224308000531	L5 interface [polypeptide binding]; other site
224308000532	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
224308000533	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
224308000534	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
224308000535	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
224308000536	23S rRNA binding site [nucleotide binding]; other site
224308000537	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
224308000538	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
224308000539	SecY translocase; Region: SecY; pfam00344
224308000540	adenylate kinase; Reviewed; Region: adk; PRK00279
224308000541	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
224308000542	AMP-binding site [chemical binding]; other site
224308000543	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
224308000544	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
224308000545	active site
224308000546	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
224308000547	RNA binding site [nucleotide binding]; other site
224308000548	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
224308000549	rRNA binding site [nucleotide binding]; other site
224308000550	predicted 30S ribosome binding site; other site
224308000551	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
224308000552	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
224308000553	30S ribosomal protein S13; Region: bact_S13; TIGR03631
224308000554	30S ribosomal protein S11; Validated; Region: PRK05309
224308000555	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
224308000556	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
224308000557	alphaNTD homodimer interface [polypeptide binding]; other site
224308000558	alphaNTD - beta interaction site [polypeptide binding]; other site
224308000559	alphaNTD - beta' interaction site [polypeptide binding]; other site
224308000560	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
224308000561	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
224308000562	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
224308000563	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
224308000564	Walker A/P-loop; other site
224308000565	ATP binding site [chemical binding]; other site
224308000566	Q-loop/lid; other site
224308000567	ABC transporter signature motif; other site
224308000568	Walker B; other site
224308000569	D-loop; other site
224308000570	H-loop/switch region; other site
224308000571	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
224308000572	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
224308000573	Walker A/P-loop; other site
224308000574	ATP binding site [chemical binding]; other site
224308000575	Q-loop/lid; other site
224308000576	ABC transporter signature motif; other site
224308000577	Walker B; other site
224308000578	D-loop; other site
224308000579	H-loop/switch region; other site
224308000580	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
224308000581	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
224308000582	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
224308000583	dimerization interface 3.5A [polypeptide binding]; other site
224308000584	active site
224308000585	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
224308000586	23S rRNA interface [nucleotide binding]; other site
224308000587	L3 interface [polypeptide binding]; other site
224308000588	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
224308000589	Methyltransferase domain; Region: Methyltransf_31; pfam13847
224308000590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308000591	S-adenosylmethionine binding site [chemical binding]; other site
224308000592	Protein of unknown function (DUF2521); Region: DUF2521; pfam10730
224308000593	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
224308000594	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
224308000595	active site
224308000596	metal binding site [ion binding]; metal-binding site
224308000597	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
224308000598	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
224308000599	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
224308000600	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
224308000601	Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949
224308000602	NodB motif; other site
224308000603	putative active site [active]
224308000604	putative catalytic site [active]
224308000605	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
224308000606	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
224308000607	Sulfate transporter family; Region: Sulfate_transp; pfam00916
224308000608	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
224308000609	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
224308000610	Sodium Bile acid symporter family; Region: SBF; cl17470
224308000611	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
224308000612	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
224308000613	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308000614	dimer interface [polypeptide binding]; other site
224308000615	putative PBP binding regions; other site
224308000616	ABC-ATPase subunit  interface; other site
224308000617	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
224308000618	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
224308000619	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308000620	ABC-ATPase subunit  interface; other site
224308000621	dimer interface [polypeptide binding]; other site
224308000622	putative PBP binding regions; other site
224308000623	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
224308000624	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
224308000625	putative ligand binding residues [chemical binding]; other site
224308000626	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308000627	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308000628	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
224308000629	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
224308000630	putative ligand binding residues [chemical binding]; other site
224308000631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876
224308000632	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
224308000633	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
224308000634	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
224308000635	putative periplasmic esterase; Provisional; Region: PRK03642
224308000636	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
224308000637	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
224308000638	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224308000639	active site turn [active]
224308000640	phosphorylation site [posttranslational modification]
224308000641	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
224308000642	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
224308000643	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
224308000644	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
224308000645	putative active site [active]
224308000646	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
224308000647	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
224308000648	putative active site [active]
224308000649	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
224308000650	Uncharacterized conserved protein [Function unknown]; Region: COG1683
224308000651	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
224308000652	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308000653	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308000654	DNA binding residues [nucleotide binding]
224308000655	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
224308000656	Putative zinc-finger; Region: zf-HC2; pfam13490
224308000657	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
224308000658	Uncharacterized conserved protein [Function unknown]; Region: COG1624
224308000659	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
224308000660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
224308000661	YbbR-like protein; Region: YbbR; pfam07949
224308000662	YbbR-like protein; Region: YbbR; pfam07949
224308000663	YbbR-like protein; Region: YbbR; pfam07949
224308000664	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
224308000665	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
224308000666	active site
224308000667	substrate binding site [chemical binding]; other site
224308000668	metal binding site [ion binding]; metal-binding site
224308000669	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
224308000670	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
224308000671	glutaminase active site [active]
224308000672	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
224308000673	dimer interface [polypeptide binding]; other site
224308000674	active site
224308000675	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
224308000676	dimer interface [polypeptide binding]; other site
224308000677	active site
224308000678	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
224308000679	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
224308000680	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224308000681	minor groove reading motif; other site
224308000682	helix-hairpin-helix signature motif; other site
224308000683	substrate binding pocket [chemical binding]; other site
224308000684	active site
224308000685	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
224308000686	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
224308000687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308000688	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308000689	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
224308000690	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
224308000691	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
224308000692	DNA binding site [nucleotide binding]
224308000693	active site
224308000694	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
224308000695	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224308000696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
224308000697	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
224308000698	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288
224308000699	zinc binding site [ion binding]; other site
224308000700	Uncharacterized conserved protein [Function unknown]; Region: COG5609
224308000701	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308000702	dimerization interface [polypeptide binding]; other site
224308000703	putative DNA binding site [nucleotide binding]; other site
224308000704	putative Zn2+ binding site [ion binding]; other site
224308000705	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224308000706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308000707	putative substrate translocation pore; other site
224308000708	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449
224308000709	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308000710	Radical SAM superfamily; Region: Radical_SAM; pfam04055
224308000711	FeS/SAM binding site; other site
224308000712	CAAX protease self-immunity; Region: Abi; pfam02517
224308000713	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
224308000714	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
224308000715	Walker A/P-loop; other site
224308000716	ATP binding site [chemical binding]; other site
224308000717	Q-loop/lid; other site
224308000718	ABC transporter signature motif; other site
224308000719	Walker B; other site
224308000720	D-loop; other site
224308000721	H-loop/switch region; other site
224308000722	HEAT repeats; Region: HEAT_2; pfam13646
224308000723	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
224308000724	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
224308000725	catalytic residues [active]
224308000726	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308000727	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308000728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308000729	active site
224308000730	phosphorylation site [posttranslational modification]
224308000731	intermolecular recognition site; other site
224308000732	dimerization interface [polypeptide binding]; other site
224308000733	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308000734	DNA binding site [nucleotide binding]
224308000735	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308000736	HAMP domain; Region: HAMP; pfam00672
224308000737	dimerization interface [polypeptide binding]; other site
224308000738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308000739	dimer interface [polypeptide binding]; other site
224308000740	phosphorylation site [posttranslational modification]
224308000741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308000742	ATP binding site [chemical binding]; other site
224308000743	Mg2+ binding site [ion binding]; other site
224308000744	G-X-G motif; other site
224308000745	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
224308000746	active site
224308000747	ATP binding site [chemical binding]; other site
224308000748	substrate binding site [chemical binding]; other site
224308000749	activation loop (A-loop); other site
224308000750	putative transport protein YifK; Provisional; Region: PRK10746
224308000751	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
224308000752	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
224308000753	Cytochrome P450; Region: p450; cl12078
224308000754	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
224308000755	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
224308000756	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
224308000757	active site
224308000758	catalytic site [active]
224308000759	metal binding site [ion binding]; metal-binding site
224308000760	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
224308000761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308000762	putative substrate translocation pore; other site
224308000763	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308000764	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
224308000765	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308000766	MarR family; Region: MarR; pfam01047
224308000767	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
224308000768	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308000769	Coenzyme A binding pocket [chemical binding]; other site
224308000770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308000771	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308000772	putative substrate translocation pore; other site
224308000773	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
224308000774	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308000775	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
224308000776	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308000777	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
224308000778	active site
224308000779	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224308000780	EamA-like transporter family; Region: EamA; pfam00892
224308000781	EamA-like transporter family; Region: EamA; pfam00892
224308000782	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
224308000783	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308000784	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308000785	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308000786	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
224308000787	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224308000788	ATP-grasp domain; Region: ATP-grasp; pfam02222
224308000789	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
224308000790	Protein of unknown function (DUF2606); Region: DUF2606; pfam10794
224308000791	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308000792	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
224308000793	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
224308000794	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
224308000795	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
224308000796	phosphatidylserine decarboxylase; Provisional; Region: PRK03140
224308000797	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
224308000798	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308000799	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308000800	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
224308000801	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
224308000802	active site residue [active]
224308000803	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
224308000804	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
224308000805	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
224308000806	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
224308000807	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
224308000808	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224308000809	active site turn [active]
224308000810	phosphorylation site [posttranslational modification]
224308000811	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
224308000812	HPr interaction site; other site
224308000813	glycerol kinase (GK) interaction site [polypeptide binding]; other site
224308000814	active site
224308000815	phosphorylation site [posttranslational modification]
224308000816	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
224308000817	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
224308000818	active site
224308000819	trimer interface [polypeptide binding]; other site
224308000820	allosteric site; other site
224308000821	active site lid [active]
224308000822	hexamer (dimer of trimers) interface [polypeptide binding]; other site
224308000823	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
224308000824	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308000825	DNA-binding site [nucleotide binding]; DNA binding site
224308000826	UTRA domain; Region: UTRA; pfam07702
224308000827	Predicted integral membrane protein [Function unknown]; Region: COG5658
224308000828	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
224308000829	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
224308000830	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
224308000831	homodimer interface [polypeptide binding]; other site
224308000832	substrate-cofactor binding pocket; other site
224308000833	catalytic residue [active]
224308000834	S-methylmethionine transporter; Provisional; Region: PRK11387
224308000835	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
224308000836	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
224308000837	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
224308000838	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
224308000839	glutaminase; Reviewed; Region: PRK12357
224308000840	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
224308000841	Chorismate mutase type II; Region: CM_2; cl00693
224308000842	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308000843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308000844	ATP binding site [chemical binding]; other site
224308000845	Mg2+ binding site [ion binding]; other site
224308000846	G-X-G motif; other site
224308000847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308000848	Response regulator receiver domain; Region: Response_reg; pfam00072
224308000849	active site
224308000850	phosphorylation site [posttranslational modification]
224308000851	intermolecular recognition site; other site
224308000852	dimerization interface [polypeptide binding]; other site
224308000853	YcbB domain; Region: YcbB; pfam08664
224308000854	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
224308000855	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
224308000856	putative active site [active]
224308000857	catalytic residue [active]
224308000858	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
224308000859	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224308000860	NAD(P) binding site [chemical binding]; other site
224308000861	catalytic residues [active]
224308000862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308000863	D-galactonate transporter; Region: 2A0114; TIGR00893
224308000864	putative substrate translocation pore; other site
224308000865	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
224308000866	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
224308000867	active site
224308000868	tetramer interface [polypeptide binding]; other site
224308000869	Transcriptional regulators [Transcription]; Region: FadR; COG2186
224308000870	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308000871	DNA-binding site [nucleotide binding]; DNA binding site
224308000872	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
224308000873	galactarate dehydratase; Region: galactar-dH20; TIGR03248
224308000874	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
224308000875	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
224308000876	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
224308000877	putative active site [active]
224308000878	putative substrate binding site [chemical binding]; other site
224308000879	Phosphotransferase enzyme family; Region: APH; pfam01636
224308000880	ATP binding site [chemical binding]; other site
224308000881	anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748
224308000882	dodecamer interface 1 [polypeptide binding]; other site
224308000883	dodecamer interface 2 [polypeptide binding]; other site
224308000884	trimer interface [polypeptide binding]; other site
224308000885	TRAP binding interface [polypeptide binding]; other site
224308000886	Zn binding site [ion binding]; other site
224308000887	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224308000888	EamA-like transporter family; Region: EamA; pfam00892
224308000889	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308000890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308000891	active site
224308000892	phosphorylation site [posttranslational modification]
224308000893	intermolecular recognition site; other site
224308000894	dimerization interface [polypeptide binding]; other site
224308000895	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308000896	DNA binding site [nucleotide binding]
224308000897	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308000898	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308000899	dimer interface [polypeptide binding]; other site
224308000900	phosphorylation site [posttranslational modification]
224308000901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308000902	ATP binding site [chemical binding]; other site
224308000903	Mg2+ binding site [ion binding]; other site
224308000904	G-X-G motif; other site
224308000905	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
224308000906	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
224308000907	Walker A/P-loop; other site
224308000908	ATP binding site [chemical binding]; other site
224308000909	Q-loop/lid; other site
224308000910	ABC transporter signature motif; other site
224308000911	Walker B; other site
224308000912	D-loop; other site
224308000913	H-loop/switch region; other site
224308000914	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
224308000915	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
224308000916	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
224308000917	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
224308000918	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
224308000919	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
224308000920	metal ion-dependent adhesion site (MIDAS); other site
224308000921	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
224308000922	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
224308000923	putative active site [active]
224308000924	putative metal binding site [ion binding]; other site
224308000925	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
224308000926	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
224308000927	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
224308000928	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
224308000929	putative substrate binding pocket [chemical binding]; other site
224308000930	AC domain interface; other site
224308000931	catalytic triad [active]
224308000932	AB domain interface; other site
224308000933	interchain disulfide; other site
224308000934	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
224308000935	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
224308000936	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224308000937	catalytic residue [active]
224308000938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308000939	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308000940	putative substrate translocation pore; other site
224308000941	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308000942	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308000943	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308000944	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
224308000945	active site
224308000946	homotetramer interface [polypeptide binding]; other site
224308000947	homodimer interface [polypeptide binding]; other site
224308000948	Lipase (class 2); Region: Lipase_2; pfam01674
224308000949	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
224308000950	Predicted membrane protein/domain [Function unknown]; Region: COG1714
224308000951	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
224308000952	helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225
224308000953	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
224308000954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308000955	ATP binding site [chemical binding]; other site
224308000956	Mg2+ binding site [ion binding]; other site
224308000957	G-X-G motif; other site
224308000958	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
224308000959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308000960	active site
224308000961	phosphorylation site [posttranslational modification]
224308000962	intermolecular recognition site; other site
224308000963	dimerization interface [polypeptide binding]; other site
224308000964	LytTr DNA-binding domain; Region: LytTR; pfam04397
224308000965	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
224308000966	ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266
224308000967	Walker A/P-loop; other site
224308000968	ATP binding site [chemical binding]; other site
224308000969	Q-loop/lid; other site
224308000970	ABC transporter signature motif; other site
224308000971	Walker B; other site
224308000972	D-loop; other site
224308000973	H-loop/switch region; other site
224308000974	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
224308000975	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
224308000976	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224308000977	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
224308000978	active site
224308000979	catalytic tetrad [active]
224308000980	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
224308000981	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
224308000982	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
224308000983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308000984	binding surface
224308000985	TPR motif; other site
224308000986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308000987	TPR motif; other site
224308000988	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308000989	binding surface
224308000990	glucose-1-dehydrogenase; Provisional; Region: PRK08936
224308000991	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
224308000992	NAD binding site [chemical binding]; other site
224308000993	homodimer interface [polypeptide binding]; other site
224308000994	active site
224308000995	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
224308000996	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
224308000997	Ca binding site [ion binding]; other site
224308000998	active site
224308000999	catalytic site [active]
224308001000	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
224308001001	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
224308001002	metal binding site [ion binding]; metal-binding site
224308001003	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
224308001004	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
224308001005	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
224308001006	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308001007	ABC-ATPase subunit  interface; other site
224308001008	dimer interface [polypeptide binding]; other site
224308001009	putative PBP binding regions; other site
224308001010	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
224308001011	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
224308001012	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
224308001013	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
224308001014	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
224308001015	putative metal binding site [ion binding]; other site
224308001016	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
224308001017	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
224308001018	putative metal binding site [ion binding]; other site
224308001019	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
224308001020	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
224308001021	putative metal binding site [ion binding]; other site
224308001022	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
224308001023	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
224308001024	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
224308001025	benzoate transport; Region: 2A0115; TIGR00895
224308001026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001027	putative substrate translocation pore; other site
224308001028	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224308001029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001030	putative substrate translocation pore; other site
224308001031	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308001032	dimerization interface [polypeptide binding]; other site
224308001033	putative DNA binding site [nucleotide binding]; other site
224308001034	putative Zn2+ binding site [ion binding]; other site
224308001035	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
224308001036	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
224308001037	Walker A/P-loop; other site
224308001038	ATP binding site [chemical binding]; other site
224308001039	Q-loop/lid; other site
224308001040	ABC transporter signature motif; other site
224308001041	Walker B; other site
224308001042	D-loop; other site
224308001043	H-loop/switch region; other site
224308001044	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
224308001045	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
224308001046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308001047	dimer interface [polypeptide binding]; other site
224308001048	conserved gate region; other site
224308001049	putative PBP binding loops; other site
224308001050	ABC-ATPase subunit interface; other site
224308001051	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
224308001052	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
224308001053	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
224308001054	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
224308001055	amidohydrolase; Region: amidohydrolases; TIGR01891
224308001056	metal binding site [ion binding]; metal-binding site
224308001057	putative dimer interface [polypeptide binding]; other site
224308001058	Predicted membrane protein [Function unknown]; Region: COG1288
224308001059	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
224308001060	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
224308001061	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
224308001062	active site
224308001063	Ca binding site [ion binding]; other site
224308001064	catalytic site [active]
224308001065	Aamy_C domain; Region: Aamy_C; smart00632
224308001066	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
224308001067	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
224308001068	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224308001069	NAD binding site [chemical binding]; other site
224308001070	dimer interface [polypeptide binding]; other site
224308001071	substrate binding site [chemical binding]; other site
224308001072	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
224308001073	L-lactate permease; Region: Lactate_perm; pfam02652
224308001074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001075	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308001076	putative substrate translocation pore; other site
224308001077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001078	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308001079	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308001080	putative DNA binding site [nucleotide binding]; other site
224308001081	putative Zn2+ binding site [ion binding]; other site
224308001082	LysE type translocator; Region: LysE; pfam01810
224308001083	Uncharacterized conserved protein [Function unknown]; Region: COG3403
224308001084	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
224308001085	Spore germination protein; Region: Spore_permease; cl17796
224308001086	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
224308001087	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
224308001088	NAD+ synthetase; Region: nadE; TIGR00552
224308001089	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
224308001090	homodimer interface [polypeptide binding]; other site
224308001091	NAD binding pocket [chemical binding]; other site
224308001092	ATP binding pocket [chemical binding]; other site
224308001093	Mg binding site [ion binding]; other site
224308001094	active-site loop [active]
224308001095	AAA domain; Region: AAA_17; cl17253
224308001096	AAA domain; Region: AAA_18; pfam13238
224308001097	shikimate kinase; Reviewed; Region: aroK; PRK00131
224308001098	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
224308001099	ADP binding site [chemical binding]; other site
224308001100	magnesium binding site [ion binding]; other site
224308001101	putative shikimate binding site; other site
224308001102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308001103	S-adenosylmethionine binding site [chemical binding]; other site
224308001104	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308001105	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308001106	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308001107	dimerization interface [polypeptide binding]; other site
224308001108	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
224308001109	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
224308001110	Proline dehydrogenase; Region: Pro_dh; pfam01619
224308001111	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
224308001112	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
224308001113	Glutamate binding site [chemical binding]; other site
224308001114	homodimer interface [polypeptide binding]; other site
224308001115	NAD binding site [chemical binding]; other site
224308001116	catalytic residues [active]
224308001117	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
224308001118	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
224308001119	Na binding site [ion binding]; other site
224308001120	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
224308001121	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
224308001122	Predicted membrane protein [Function unknown]; Region: COG3689
224308001123	Predicted permeases [General function prediction only]; Region: COG0701
224308001124	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308001125	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
224308001126	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
224308001127	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308001128	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
224308001129	active site
224308001130	SAM binding site [chemical binding]; other site
224308001131	homodimer interface [polypeptide binding]; other site
224308001132	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
224308001133	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
224308001134	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
224308001135	[2Fe-2S] cluster binding site [ion binding]; other site
224308001136	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
224308001137	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308001138	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
224308001139	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
224308001140	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224308001141	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
224308001142	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
224308001143	[4Fe-4S] binding site [ion binding]; other site
224308001144	molybdopterin cofactor binding site; other site
224308001145	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
224308001146	molybdopterin cofactor binding site; other site
224308001147	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
224308001148	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308001149	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
224308001150	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
224308001151	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224308001152	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
224308001153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001154	putative substrate translocation pore; other site
224308001155	Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642
224308001156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
224308001157	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
224308001158	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
224308001159	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
224308001160	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
224308001161	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
224308001162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308001163	dimer interface [polypeptide binding]; other site
224308001164	conserved gate region; other site
224308001165	putative PBP binding loops; other site
224308001166	ABC-ATPase subunit interface; other site
224308001167	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
224308001168	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224308001169	substrate binding pocket [chemical binding]; other site
224308001170	membrane-bound complex binding site; other site
224308001171	hinge residues; other site
224308001172	RDD family; Region: RDD; pfam06271
224308001173	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
224308001174	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
224308001175	beta-galactosidase; Region: BGL; TIGR03356
224308001176	Competence protein J (ComJ); Region: ComJ; pfam11033
224308001177	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
224308001178	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308001179	dimerization interface [polypeptide binding]; other site
224308001180	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308001181	dimer interface [polypeptide binding]; other site
224308001182	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
224308001183	putative CheW interface [polypeptide binding]; other site
224308001184	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
224308001185	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
224308001186	tetramer interface [polypeptide binding]; other site
224308001187	active site
224308001188	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
224308001189	active site
224308001190	dimer interface [polypeptide binding]; other site
224308001191	magnesium binding site [ion binding]; other site
224308001192	Predicted transcriptional regulators [Transcription]; Region: COG1733
224308001193	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
224308001194	Condensation domain; Region: Condensation; pfam00668
224308001195	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308001196	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308001197	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308001198	acyl-activating enzyme (AAE) consensus motif; other site
224308001199	AMP binding site [chemical binding]; other site
224308001200	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308001201	Condensation domain; Region: Condensation; pfam00668
224308001202	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308001203	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308001204	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
224308001205	acyl-activating enzyme (AAE) consensus motif; other site
224308001206	AMP binding site [chemical binding]; other site
224308001207	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308001208	Condensation domain; Region: Condensation; pfam00668
224308001209	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308001210	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308001211	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308001212	acyl-activating enzyme (AAE) consensus motif; other site
224308001213	AMP binding site [chemical binding]; other site
224308001214	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308001215	Condensation domain; Region: Condensation; pfam00668
224308001216	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308001217	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
224308001218	Condensation domain; Region: Condensation; pfam00668
224308001219	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308001220	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
224308001221	acyl-activating enzyme (AAE) consensus motif; other site
224308001222	AMP binding site [chemical binding]; other site
224308001223	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308001224	Condensation domain; Region: Condensation; pfam00668
224308001225	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308001226	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308001227	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308001228	acyl-activating enzyme (AAE) consensus motif; other site
224308001229	AMP binding site [chemical binding]; other site
224308001230	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308001231	Condensation domain; Region: Condensation; pfam00668
224308001232	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308001233	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308001234	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308001235	acyl-activating enzyme (AAE) consensus motif; other site
224308001236	AMP binding site [chemical binding]; other site
224308001237	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308001238	Condensation domain; Region: Condensation; pfam00668
224308001239	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
224308001240	Condensation domain; Region: Condensation; pfam00668
224308001241	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308001242	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
224308001243	acyl-activating enzyme (AAE) consensus motif; other site
224308001244	AMP binding site [chemical binding]; other site
224308001245	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308001246	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
224308001247	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
224308001248	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
224308001249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001250	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308001251	putative substrate translocation pore; other site
224308001252	YcxB-like protein; Region: YcxB; pfam14317
224308001253	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224308001254	EamA-like transporter family; Region: EamA; pfam00892
224308001255	EamA-like transporter family; Region: EamA; pfam00892
224308001256	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
224308001257	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308001258	DNA-binding site [nucleotide binding]; DNA binding site
224308001259	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308001260	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308001261	homodimer interface [polypeptide binding]; other site
224308001262	catalytic residue [active]
224308001263	Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 10568751, 17376553, 2848009, 9384377; Product type e: enzyme
224308001264	Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 10568751, 17376553, 2848009, 9384377; Product type e: enzyme
224308001265	Predicted membrane protein [Function unknown]; Region: COG2364
224308001266	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308001267	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224308001268	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
224308001269	Walker A/P-loop; other site
224308001270	ATP binding site [chemical binding]; other site
224308001271	Q-loop/lid; other site
224308001272	ABC transporter signature motif; other site
224308001273	Walker B; other site
224308001274	D-loop; other site
224308001275	H-loop/switch region; other site
224308001276	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
224308001277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308001278	dimer interface [polypeptide binding]; other site
224308001279	conserved gate region; other site
224308001280	putative PBP binding loops; other site
224308001281	ABC-ATPase subunit interface; other site
224308001282	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
224308001283	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224308001284	substrate binding pocket [chemical binding]; other site
224308001285	membrane-bound complex binding site; other site
224308001286	hinge residues; other site
224308001287	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308001288	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308001289	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308001290	dimerization interface [polypeptide binding]; other site
224308001291	polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421
224308001292	Flavoprotein; Region: Flavoprotein; pfam02441
224308001293	UbiD family decarboxylase; Region: TIGR00148
224308001294	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
224308001295	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308001296	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
224308001297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001298	putative substrate translocation pore; other site
224308001299	POT family; Region: PTR2; pfam00854
224308001300	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
224308001301	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
224308001302	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
224308001303	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
224308001304	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
224308001305	Spore germination protein; Region: Spore_permease; pfam03845
224308001306	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224308001307	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
224308001308	Walker A/P-loop; other site
224308001309	ATP binding site [chemical binding]; other site
224308001310	Q-loop/lid; other site
224308001311	ABC transporter signature motif; other site
224308001312	Walker B; other site
224308001313	D-loop; other site
224308001314	H-loop/switch region; other site
224308001315	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
224308001316	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
224308001317	FtsX-like permease family; Region: FtsX; pfam02687
224308001318	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308001319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308001320	active site
224308001321	phosphorylation site [posttranslational modification]
224308001322	intermolecular recognition site; other site
224308001323	dimerization interface [polypeptide binding]; other site
224308001324	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308001325	DNA binding site [nucleotide binding]
224308001326	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308001327	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308001328	dimerization interface [polypeptide binding]; other site
224308001329	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308001330	dimer interface [polypeptide binding]; other site
224308001331	phosphorylation site [posttranslational modification]
224308001332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308001333	ATP binding site [chemical binding]; other site
224308001334	Mg2+ binding site [ion binding]; other site
224308001335	G-X-G motif; other site
224308001336	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308001337	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308001338	TPR motif; other site
224308001339	binding surface
224308001340	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308001341	Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131
224308001342	similar to hypothetical protein; Evidence 6: Doubtful CDS
224308001343	aspartate kinase; Reviewed; Region: PRK09034
224308001344	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
224308001345	putative catalytic residues [active]
224308001346	putative nucleotide binding site [chemical binding]; other site
224308001347	putative aspartate binding site [chemical binding]; other site
224308001348	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
224308001349	allosteric regulatory residue; other site
224308001350	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
224308001351	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
224308001352	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308001353	ABC-ATPase subunit  interface; other site
224308001354	dimer interface [polypeptide binding]; other site
224308001355	putative PBP binding regions; other site
224308001356	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308001357	ABC-ATPase subunit  interface; other site
224308001358	dimer interface [polypeptide binding]; other site
224308001359	putative PBP binding regions; other site
224308001360	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
224308001361	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
224308001362	Walker A/P-loop; other site
224308001363	ATP binding site [chemical binding]; other site
224308001364	Q-loop/lid; other site
224308001365	ABC transporter signature motif; other site
224308001366	Walker B; other site
224308001367	D-loop; other site
224308001368	H-loop/switch region; other site
224308001369	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
224308001370	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
224308001371	putative ligand binding residues [chemical binding]; other site
224308001372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001373	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308001374	putative substrate translocation pore; other site
224308001375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001376	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308001377	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308001378	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
224308001379	dimer interface [polypeptide binding]; other site
224308001380	FMN binding site [chemical binding]; other site
224308001381	NADPH bind site [chemical binding]; other site
224308001382	Uncharacterized conserved protein [Function unknown]; Region: COG1359
224308001383	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308001384	dimerization interface [polypeptide binding]; other site
224308001385	putative DNA binding site [nucleotide binding]; other site
224308001386	putative Zn2+ binding site [ion binding]; other site
224308001387	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
224308001388	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308001389	DNA-binding site [nucleotide binding]; DNA binding site
224308001390	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308001391	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308001392	homodimer interface [polypeptide binding]; other site
224308001393	catalytic residue [active]
224308001394	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
224308001395	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224308001396	inhibitor-cofactor binding pocket; inhibition site
224308001397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308001398	catalytic residue [active]
224308001399	succinic semialdehyde dehydrogenase; Region: PLN02278
224308001400	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
224308001401	tetramerization interface [polypeptide binding]; other site
224308001402	NAD(P) binding site [chemical binding]; other site
224308001403	catalytic residues [active]
224308001404	Sugar transport protein; Region: Sugar_transport; pfam06800
224308001405	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
224308001406	glucose-1-dehydrogenase; Provisional; Region: PRK08936
224308001407	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
224308001408	NAD binding site [chemical binding]; other site
224308001409	homodimer interface [polypeptide binding]; other site
224308001410	active site
224308001411	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
224308001412	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
224308001413	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
224308001414	YtkA-like; Region: YtkA; pfam13115
224308001415	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224308001416	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
224308001417	NosL; Region: NosL; cl01769
224308001418	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
224308001419	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
224308001420	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
224308001421	active site
224308001422	P-loop; other site
224308001423	phosphorylation site [posttranslational modification]
224308001424	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
224308001425	active site
224308001426	phosphorylation site [posttranslational modification]
224308001427	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
224308001428	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
224308001429	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
224308001430	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
224308001431	tartrate dehydrogenase; Provisional; Region: PRK08194
224308001432	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
224308001433	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224308001434	Catalytic site [active]
224308001435	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
224308001436	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
224308001437	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
224308001438	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308001439	active site
224308001440	motif I; other site
224308001441	motif II; other site
224308001442	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308001443	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
224308001444	putative active site [active]
224308001445	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
224308001446	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
224308001447	hypothetical protein; Provisional; Region: PRK05463
224308001448	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
224308001449	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
224308001450	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
224308001451	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
224308001452	Transcriptional regulator [Transcription]; Region: IclR; COG1414
224308001453	Bacterial transcriptional regulator; Region: IclR; pfam01614
224308001454	Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755
224308001455	active site
224308001456	catalytic triad [active]
224308001457	oxyanion hole [active]
224308001458	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
224308001459	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
224308001460	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
224308001461	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
224308001462	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
224308001463	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224308001464	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224308001465	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
224308001466	active site
224308001467	catalytic tetrad [active]
224308001468	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
224308001469	HTH domain; Region: HTH_11; pfam08279
224308001470	PRD domain; Region: PRD; pfam00874
224308001471	PRD domain; Region: PRD; pfam00874
224308001472	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
224308001473	active site
224308001474	P-loop; other site
224308001475	phosphorylation site [posttranslational modification]
224308001476	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
224308001477	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
224308001478	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
224308001479	acyl-activating enzyme (AAE) consensus motif; other site
224308001480	putative AMP binding site [chemical binding]; other site
224308001481	putative active site [active]
224308001482	putative CoA binding site [chemical binding]; other site
224308001483	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308001484	S-adenosylmethionine binding site [chemical binding]; other site
224308001485	short chain dehydrogenase; Provisional; Region: PRK06701
224308001486	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
224308001487	NAD binding site [chemical binding]; other site
224308001488	metal binding site [ion binding]; metal-binding site
224308001489	active site
224308001490	ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822
224308001491	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224308001492	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
224308001493	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
224308001494	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
224308001495	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
224308001496	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
224308001497	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
224308001498	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
224308001499	putative DNA binding site [nucleotide binding]; other site
224308001500	putative Zn2+ binding site [ion binding]; other site
224308001501	AsnC family; Region: AsnC_trans_reg; pfam01037
224308001502	DNA topoisomerase III; Provisional; Region: PRK07726
224308001503	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
224308001504	active site
224308001505	putative interdomain interaction site [polypeptide binding]; other site
224308001506	putative metal-binding site [ion binding]; other site
224308001507	putative nucleotide binding site [chemical binding]; other site
224308001508	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
224308001509	domain I; other site
224308001510	DNA binding groove [nucleotide binding]
224308001511	phosphate binding site [ion binding]; other site
224308001512	domain II; other site
224308001513	domain III; other site
224308001514	nucleotide binding site [chemical binding]; other site
224308001515	catalytic site [active]
224308001516	domain IV; other site
224308001517	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
224308001518	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
224308001519	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
224308001520	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224308001521	metal binding site [ion binding]; metal-binding site
224308001522	active site
224308001523	I-site; other site
224308001524	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
224308001525	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
224308001526	NodB motif; other site
224308001527	putative active site [active]
224308001528	putative catalytic site [active]
224308001529	putative Zn binding site [ion binding]; other site
224308001530	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
224308001531	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
224308001532	DXD motif; other site
224308001533	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
224308001534	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
224308001535	Amino acid permease; Region: AA_permease_2; pfam13520
224308001536	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
224308001537	nudix motif; other site
224308001538	pyruvate oxidase; Provisional; Region: PRK08611
224308001539	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
224308001540	PYR/PP interface [polypeptide binding]; other site
224308001541	tetramer interface [polypeptide binding]; other site
224308001542	dimer interface [polypeptide binding]; other site
224308001543	TPP binding site [chemical binding]; other site
224308001544	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
224308001545	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
224308001546	TPP-binding site [chemical binding]; other site
224308001547	manganese transport protein MntH; Reviewed; Region: PRK00701
224308001548	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
224308001549	Predicted membrane protein [Function unknown]; Region: COG2261
224308001550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
224308001551	EcsC protein family; Region: EcsC; pfam12787
224308001552	General stress protein [General function prediction only]; Region: GsiB; COG3729
224308001553	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
224308001554	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
224308001555	dimanganese center [ion binding]; other site
224308001556	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
224308001557	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
224308001558	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
224308001559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308001560	putative active site [active]
224308001561	heme pocket [chemical binding]; other site
224308001562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308001563	ATP binding site [chemical binding]; other site
224308001564	Mg2+ binding site [ion binding]; other site
224308001565	G-X-G motif; other site
224308001566	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
224308001567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308001568	active site
224308001569	phosphorylation site [posttranslational modification]
224308001570	intermolecular recognition site; other site
224308001571	dimerization interface [polypeptide binding]; other site
224308001572	HTH domain; Region: HTH_11; cl17392
224308001573	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
224308001574	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
224308001575	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
224308001576	Domain of unknown function DUF20; Region: UPF0118; pfam01594
224308001577	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
224308001578	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224308001579	Walker A/P-loop; other site
224308001580	ATP binding site [chemical binding]; other site
224308001581	Q-loop/lid; other site
224308001582	ABC transporter signature motif; other site
224308001583	Walker B; other site
224308001584	D-loop; other site
224308001585	H-loop/switch region; other site
224308001586	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
224308001587	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
224308001588	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224308001589	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
224308001590	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
224308001591	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
224308001592	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
224308001593	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
224308001594	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224308001595	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
224308001596	catalytic residues [active]
224308001597	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
224308001598	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
224308001599	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
224308001600	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
224308001601	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224308001602	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224308001603	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224308001604	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
224308001605	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
224308001606	ATP binding site [chemical binding]; other site
224308001607	Mg++ binding site [ion binding]; other site
224308001608	motif III; other site
224308001609	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308001610	nucleotide binding region [chemical binding]; other site
224308001611	ATP-binding site [chemical binding]; other site
224308001612	Uncharacterized conserved protein [Function unknown]; Region: COG3402
224308001613	Predicted membrane protein [Function unknown]; Region: COG3428
224308001614	Bacterial PH domain; Region: DUF304; pfam03703
224308001615	Bacterial PH domain; Region: DUF304; pfam03703
224308001616	Bacterial PH domain; Region: DUF304; pfam03703
224308001617	Rhomboid family; Region: Rhomboid; pfam01694
224308001618	holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516
224308001619	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
224308001620	alanine racemase; Region: alr; TIGR00492
224308001621	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
224308001622	active site
224308001623	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224308001624	dimer interface [polypeptide binding]; other site
224308001625	substrate binding site [chemical binding]; other site
224308001626	catalytic residues [active]
224308001627	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
224308001628	ribbon-helix-helix domain containing protein; Region: PHA00617
224308001629	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
224308001630	Rsbr N terminal; Region: Rsbr_N; pfam08678
224308001631	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
224308001632	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
224308001633	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
224308001634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308001635	ATP binding site [chemical binding]; other site
224308001636	Mg2+ binding site [ion binding]; other site
224308001637	G-X-G motif; other site
224308001638	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
224308001639	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
224308001640	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
224308001641	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
224308001642	anti sigma factor interaction site; other site
224308001643	regulatory phosphorylation site [posttranslational modification]; other site
224308001644	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
224308001645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308001646	ATP binding site [chemical binding]; other site
224308001647	Mg2+ binding site [ion binding]; other site
224308001648	G-X-G motif; other site
224308001649	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
224308001650	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308001651	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224308001652	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308001653	DNA binding residues [nucleotide binding]
224308001654	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
224308001655	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
224308001656	hypothetical protein; Provisional; Region: PRK02268
224308001657	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308001658	MarR family; Region: MarR; pfam01047
224308001659	MarR family; Region: MarR_2; cl17246
224308001660	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
224308001661	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
224308001662	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
224308001663	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
224308001664	RNA binding site [nucleotide binding]; other site
224308001665	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
224308001666	hypothetical protein; Provisional; Region: PRK04351
224308001667	integrase; Provisional; Region: int; PHA02601
224308001668	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
224308001669	Int/Topo IB signature motif; other site
224308001670	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
224308001671	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308001672	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308001673	non-specific DNA binding site [nucleotide binding]; other site
224308001674	salt bridge; other site
224308001675	sequence-specific DNA binding site [nucleotide binding]; other site
224308001676	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
224308001677	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
224308001678	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
224308001679	Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946
224308001680	Replication initiation factor; Region: Rep_trans; pfam02486
224308001681	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
224308001682	TcpE family; Region: TcpE; pfam12648
224308001683	AAA-like domain; Region: AAA_10; pfam12846
224308001684	Domain of unknown function (DUF1874); Region: DUF1874; pfam08960
224308001685	Helicobacter pylori protein of unknown function (DUF874); Region: DUF874; pfam05917
224308001686	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
224308001687	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224308001688	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224308001689	catalytic residue [active]
224308001690	NlpC/P60 family; Region: NLPC_P60; pfam00877
224308001691	Toll - interleukin 1 - resistance; Region: TIR; smart00255
224308001692	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308001693	binding surface
224308001694	TPR motif; other site
224308001695	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308001696	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
224308001697	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
224308001698	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
224308001699	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
224308001700	AsnC family; Region: AsnC_trans_reg; pfam01037
224308001701	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
224308001702	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
224308001703	putative DNA binding site [nucleotide binding]; other site
224308001704	putative Zn2+ binding site [ion binding]; other site
224308001705	AsnC family; Region: AsnC_trans_reg; pfam01037
224308001706	Isochorismatase family; Region: Isochorismatase; pfam00857
224308001707	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
224308001708	catalytic triad [active]
224308001709	conserved cis-peptide bond; other site
224308001710	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
224308001711	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
224308001712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001713	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308001714	putative substrate translocation pore; other site
224308001715	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
224308001716	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
224308001717	conserved cys residue [active]
224308001718	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
224308001719	DNA-binding site [nucleotide binding]; DNA binding site
224308001720	RNA-binding motif; other site
224308001721	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
224308001722	EamA-like transporter family; Region: EamA; pfam00892
224308001723	Cupin domain; Region: Cupin_2; pfam07883
224308001724	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308001725	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308001726	EamA-like transporter family; Region: EamA; pfam00892
224308001727	EamA-like transporter family; Region: EamA; pfam00892
224308001728	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308001729	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308001730	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
224308001731	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
224308001732	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308001733	DNA-binding site [nucleotide binding]; DNA binding site
224308001734	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308001735	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308001736	homodimer interface [polypeptide binding]; other site
224308001737	catalytic residue [active]
224308001738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001739	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308001740	putative substrate translocation pore; other site
224308001741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
224308001742	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
224308001743	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
224308001744	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224308001745	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
224308001746	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308001747	DNA-binding site [nucleotide binding]; DNA binding site
224308001748	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308001749	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308001750	homodimer interface [polypeptide binding]; other site
224308001751	catalytic residue [active]
224308001752	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
224308001753	putative active site [active]
224308001754	putative catalytic site [active]
224308001755	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
224308001756	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
224308001757	Predicted transcriptional regulators [Transcription]; Region: COG1733
224308001758	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
224308001759	Uncharacterized conserved protein [Function unknown]; Region: COG1284
224308001760	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308001761	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308001762	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
224308001763	Predicted transcriptional regulators [Transcription]; Region: COG1733
224308001764	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
224308001765	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
224308001766	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
224308001767	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224308001768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001769	putative substrate translocation pore; other site
224308001770	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308001771	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308001772	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308001773	dimerization interface [polypeptide binding]; other site
224308001774	putative DNA binding site [nucleotide binding]; other site
224308001775	putative Zn2+ binding site [ion binding]; other site
224308001776	arsenical pump membrane protein; Provisional; Region: PRK15445
224308001777	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
224308001778	transmembrane helices; other site
224308001779	Evidence 4: Homologs of previously reported genes of unknown function
224308001780	Evidence 4: Homologs of previously reported genes of unknown function
224308001781	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
224308001782	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
224308001783	EamA-like transporter family; Region: EamA; pfam00892
224308001784	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
224308001785	EamA-like transporter family; Region: EamA; pfam00892
224308001786	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
224308001787	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308001788	DNA-binding site [nucleotide binding]; DNA binding site
224308001789	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308001790	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308001791	homodimer interface [polypeptide binding]; other site
224308001792	catalytic residue [active]
224308001793	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
224308001794	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308001795	putative DNA binding site [nucleotide binding]; other site
224308001796	putative Zn2+ binding site [ion binding]; other site
224308001797	Uncharacterized conserved protein [Function unknown]; Region: COG2128
224308001798	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
224308001799	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
224308001800	Histidine kinase; Region: HisKA_3; pfam07730
224308001801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308001802	ATP binding site [chemical binding]; other site
224308001803	Mg2+ binding site [ion binding]; other site
224308001804	G-X-G motif; other site
224308001805	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308001806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308001807	active site
224308001808	phosphorylation site [posttranslational modification]
224308001809	intermolecular recognition site; other site
224308001810	dimerization interface [polypeptide binding]; other site
224308001811	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308001812	DNA binding residues [nucleotide binding]
224308001813	dimerization interface [polypeptide binding]; other site
224308001814	MMPL family; Region: MMPL; pfam03176
224308001815	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
224308001816	MMPL family; Region: MMPL; pfam03176
224308001817	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308001818	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
224308001819	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
224308001820	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224308001821	DNA binding residues [nucleotide binding]
224308001822	drug binding residues [chemical binding]; other site
224308001823	dimer interface [polypeptide binding]; other site
224308001824	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
224308001825	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
224308001826	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
224308001827	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
224308001828	dimer interface [polypeptide binding]; other site
224308001829	FMN binding site [chemical binding]; other site
224308001830	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
224308001831	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308001832	Zn binding site [ion binding]; other site
224308001833	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
224308001834	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308001835	Zn binding site [ion binding]; other site
224308001836	Predicted membrane protein [Function unknown]; Region: COG2259
224308001837	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224308001838	catalytic residues [active]
224308001839	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
224308001840	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
224308001841	Predicted membrane protein [Function unknown]; Region: COG2323
224308001842	Predicted membrane protein [Function unknown]; Region: COG2323
224308001843	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
224308001844	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
224308001845	putative dimer interface [polypeptide binding]; other site
224308001846	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
224308001847	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
224308001848	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308001849	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308001850	DoxX-like family; Region: DoxX_2; pfam13564
224308001851	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
224308001852	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308001853	Coenzyme A binding pocket [chemical binding]; other site
224308001854	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
224308001855	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308001856	ABC transporter; Region: ABC_tran_2; pfam12848
224308001857	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308001858	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
224308001859	DinB family; Region: DinB; pfam05163
224308001860	DinB superfamily; Region: DinB_2; pfam12867
224308001861	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308001862	MarR family; Region: MarR; pfam01047
224308001863	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
224308001864	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
224308001865	dimer interface [polypeptide binding]; other site
224308001866	FMN binding site [chemical binding]; other site
224308001867	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308001868	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308001869	putative DNA binding site [nucleotide binding]; other site
224308001870	putative Zn2+ binding site [ion binding]; other site
224308001871	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
224308001872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001873	putative substrate translocation pore; other site
224308001874	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
224308001875	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224308001876	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308001877	DNA-binding site [nucleotide binding]; DNA binding site
224308001878	FCD domain; Region: FCD; pfam07729
224308001879	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
224308001880	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308001881	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308001882	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
224308001883	active site
224308001884	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
224308001885	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
224308001886	homodimer interface [polypeptide binding]; other site
224308001887	active site
224308001888	TDP-binding site; other site
224308001889	acceptor substrate-binding pocket; other site
224308001890	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
224308001891	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
224308001892	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
224308001893	dimer interface [polypeptide binding]; other site
224308001894	active site
224308001895	Uncharacterized conserved protein [Function unknown]; Region: COG5646
224308001896	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308001897	Coenzyme A binding pocket [chemical binding]; other site
224308001898	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
224308001899	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224308001900	Zn2+ binding site [ion binding]; other site
224308001901	Mg2+ binding site [ion binding]; other site
224308001902	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
224308001903	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
224308001904	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224308001905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308001906	putative substrate translocation pore; other site
224308001907	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
224308001908	active site
224308001909	P-loop; other site
224308001910	phosphorylation site [posttranslational modification]
224308001911	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
224308001912	active site
224308001913	methionine cluster; other site
224308001914	phosphorylation site [posttranslational modification]
224308001915	metal binding site [ion binding]; metal-binding site
224308001916	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
224308001917	PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410
224308001918	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
224308001919	beta-galactosidase; Region: BGL; TIGR03356
224308001920	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
224308001921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308001922	DNA-binding site [nucleotide binding]; DNA binding site
224308001923	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
224308001924	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
224308001925	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224308001926	nucleotide binding site [chemical binding]; other site
224308001927	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
224308001928	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
224308001929	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
224308001930	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308001931	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308001932	thiamine-monophosphate kinase; Region: thiL; TIGR01379
224308001933	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
224308001934	ATP binding site [chemical binding]; other site
224308001935	dimerization interface [polypeptide binding]; other site
224308001936	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
224308001937	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
224308001938	Glycoprotease family; Region: Peptidase_M22; pfam00814
224308001939	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
224308001940	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308001941	Coenzyme A binding pocket [chemical binding]; other site
224308001942	UGMP family protein; Validated; Region: PRK09604
224308001943	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224308001944	nucleotide binding site [chemical binding]; other site
224308001945	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
224308001946	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308001947	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308001948	ABC transporter; Region: ABC_tran_2; pfam12848
224308001949	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308001950	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
224308001951	trimer interface [polypeptide binding]; other site
224308001952	dimer interface [polypeptide binding]; other site
224308001953	putative active site [active]
224308001954	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
224308001955	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
224308001956	CoA binding domain; Region: CoA_binding; pfam02629
224308001957	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
224308001958	Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945
224308001959	Domain of unknown function (DUF4305); Region: DUF4305; pfam14146
224308001960	CAAX protease self-immunity; Region: Abi; pfam02517
224308001961	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
224308001962	oligomerisation interface [polypeptide binding]; other site
224308001963	mobile loop; other site
224308001964	roof hairpin; other site
224308001965	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
224308001966	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
224308001967	ring oligomerisation interface [polypeptide binding]; other site
224308001968	ATP/Mg binding site [chemical binding]; other site
224308001969	stacking interactions; other site
224308001970	hinge regions; other site
224308001971	Evidence 7: Gene remnant
224308001972	Evidence 7: Gene remnant
224308001973	Evidence 7: Gene remnant
224308001974	Evidence 7: Gene remnant; Product type e : enzyme
224308001975	Evidence 7: Gene remnant; Product type pe : enzyme
224308001976	Evidence 4: Homologs of previously reported genes of unknown function; Product type h: extrachromosomal origin
224308001977	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
224308001978	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
224308001979	cofactor binding site; other site
224308001980	DNA binding site [nucleotide binding]
224308001981	substrate interaction site [chemical binding]; other site
224308001982	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
224308001983	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
224308001984	cofactor binding site; other site
224308001985	DNA binding site [nucleotide binding]
224308001986	substrate interaction site [chemical binding]; other site
224308001987	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308001988	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308001989	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308001990	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308001991	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308001992	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308001993	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308001994	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
224308001995	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
224308001996	LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563
224308001997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
224308001998	Walker A motif; other site
224308001999	ATP binding site [chemical binding]; other site
224308002000	Walker B motif; other site
224308002001	TPR repeat; Region: TPR_11; pfam13414
224308002002	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308002003	TPR motif; other site
224308002004	TPR repeat; Region: TPR_11; pfam13414
224308002005	binding surface
224308002006	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
224308002007	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
224308002008	inhibitor binding site; inhibition site
224308002009	catalytic Zn binding site [ion binding]; other site
224308002010	structural Zn binding site [ion binding]; other site
224308002011	NADP binding site [chemical binding]; other site
224308002012	tetramer interface [polypeptide binding]; other site
224308002013	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
224308002014	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002015	putative substrate translocation pore; other site
224308002016	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224308002017	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
224308002018	putative substrate binding site [chemical binding]; other site
224308002019	putative ATP binding site [chemical binding]; other site
224308002020	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
224308002021	TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271
224308002022	DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981
224308002023	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
224308002024	Repair protein; Region: Repair_PSII; pfam04536
224308002025	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
224308002026	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
224308002027	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
224308002028	Double zinc ribbon; Region: DZR; pfam12773
224308002029	Ion channel; Region: Ion_trans_2; pfam07885
224308002030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002031	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
224308002032	putative substrate translocation pore; other site
224308002033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002034	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
224308002035	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
224308002036	putative NAD(P) binding site [chemical binding]; other site
224308002037	catalytic Zn binding site [ion binding]; other site
224308002038	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
224308002039	Cold-inducible protein YdjO; Region: YdjO; pfam14169
224308002040	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308002041	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
224308002042	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
224308002043	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
224308002044	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
224308002045	Multicopper oxidase; Region: Cu-oxidase; pfam00394
224308002046	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
224308002047	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
224308002048	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
224308002049	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
224308002050	MoxR-like ATPases [General function prediction only]; Region: COG0714
224308002051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308002052	Walker A motif; other site
224308002053	ATP binding site [chemical binding]; other site
224308002054	Walker B motif; other site
224308002055	arginine finger; other site
224308002056	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
224308002057	Protein of unknown function DUF58; Region: DUF58; pfam01882
224308002058	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
224308002059	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
224308002060	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
224308002061	GMP synthase; Reviewed; Region: guaA; PRK00074
224308002062	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
224308002063	AMP/PPi binding site [chemical binding]; other site
224308002064	candidate oxyanion hole; other site
224308002065	catalytic triad [active]
224308002066	potential glutamine specificity residues [chemical binding]; other site
224308002067	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
224308002068	ATP Binding subdomain [chemical binding]; other site
224308002069	Ligand Binding sites [chemical binding]; other site
224308002070	Dimerization subdomain; other site
224308002071	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
224308002072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
224308002073	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
224308002074	NETI protein; Region: NETI; pfam14044
224308002075	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
224308002076	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
224308002077	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
224308002078	NAD binding site [chemical binding]; other site
224308002079	ATP-grasp domain; Region: ATP-grasp; pfam02222
224308002080	adenylosuccinate lyase; Provisional; Region: PRK07492
224308002081	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
224308002082	tetramer interface [polypeptide binding]; other site
224308002083	active site
224308002084	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
224308002085	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
224308002086	ATP binding site [chemical binding]; other site
224308002087	active site
224308002088	substrate binding site [chemical binding]; other site
224308002089	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
224308002090	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
224308002091	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
224308002092	putative active site [active]
224308002093	catalytic triad [active]
224308002094	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
224308002095	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
224308002096	dimerization interface [polypeptide binding]; other site
224308002097	ATP binding site [chemical binding]; other site
224308002098	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
224308002099	dimerization interface [polypeptide binding]; other site
224308002100	ATP binding site [chemical binding]; other site
224308002101	amidophosphoribosyltransferase; Provisional; Region: PRK07631
224308002102	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
224308002103	active site
224308002104	tetramer interface [polypeptide binding]; other site
224308002105	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308002106	active site
224308002107	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
224308002108	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
224308002109	dimerization interface [polypeptide binding]; other site
224308002110	putative ATP binding site [chemical binding]; other site
224308002111	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
224308002112	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
224308002113	active site
224308002114	substrate binding site [chemical binding]; other site
224308002115	cosubstrate binding site; other site
224308002116	catalytic site [active]
224308002117	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
224308002118	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
224308002119	purine monophosphate binding site [chemical binding]; other site
224308002120	dimer interface [polypeptide binding]; other site
224308002121	putative catalytic residues [active]
224308002122	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
224308002123	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
224308002124	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
224308002125	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
224308002126	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
224308002127	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
224308002128	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
224308002129	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308002130	putative DNA binding site [nucleotide binding]; other site
224308002131	putative Zn2+ binding site [ion binding]; other site
224308002132	AsnC family; Region: AsnC_trans_reg; pfam01037
224308002133	putative transporter; Provisional; Region: PRK11021
224308002134	Spore germination protein; Region: Spore_permease; cl17796
224308002135	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
224308002136	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
224308002137	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224308002138	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
224308002139	active site
224308002140	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224308002141	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
224308002142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
224308002143	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
224308002144	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
224308002145	active site
224308002146	FMN binding site [chemical binding]; other site
224308002147	substrate binding site [chemical binding]; other site
224308002148	3Fe-4S cluster binding site [ion binding]; other site
224308002149	PcrB family; Region: PcrB; pfam01884
224308002150	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
224308002151	substrate binding site [chemical binding]; other site
224308002152	putative active site [active]
224308002153	dimer interface [polypeptide binding]; other site
224308002154	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
224308002155	Part of AAA domain; Region: AAA_19; pfam13245
224308002156	Family description; Region: UvrD_C_2; pfam13538
224308002157	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
224308002158	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
224308002159	nucleotide binding pocket [chemical binding]; other site
224308002160	K-X-D-G motif; other site
224308002161	catalytic site [active]
224308002162	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
224308002163	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
224308002164	Helix-hairpin-helix motif; Region: HHH; pfam00633
224308002165	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
224308002166	Dimer interface [polypeptide binding]; other site
224308002167	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
224308002168	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
224308002169	putative dimer interface [polypeptide binding]; other site
224308002170	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
224308002171	putative dimer interface [polypeptide binding]; other site
224308002172	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
224308002173	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
224308002174	active site
224308002175	ATP binding site [chemical binding]; other site
224308002176	substrate binding site [chemical binding]; other site
224308002177	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
224308002178	MgtC family; Region: MgtC; pfam02308
224308002179	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
224308002180	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
224308002181	Na binding site [ion binding]; other site
224308002182	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
224308002183	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
224308002184	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
224308002185	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
224308002186	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
224308002187	GatB domain; Region: GatB_Yqey; pfam02637
224308002188	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308002189	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308002190	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
224308002191	Protein export membrane protein; Region: SecD_SecF; cl14618
224308002192	Protein export membrane protein; Region: SecD_SecF; cl14618
224308002193	putative lipid kinase; Reviewed; Region: PRK13337
224308002194	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
224308002195	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
224308002196	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
224308002197	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308002198	S-adenosylmethionine binding site [chemical binding]; other site
224308002199	Recombinase; Region: Recombinase; pfam07508
224308002200	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
224308002201	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
224308002202	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
224308002203	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
224308002204	DNA-binding interface [nucleotide binding]; DNA binding site
224308002205	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
224308002206	Methyltransferase domain; Region: Methyltransf_26; pfam13659
224308002207	DEAD-like helicases superfamily; Region: DEXDc; smart00487
224308002208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308002209	ATP binding site [chemical binding]; other site
224308002210	putative Mg++ binding site [ion binding]; other site
224308002211	T5orf172 domain; Region: T5orf172; pfam10544
224308002212	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
224308002213	Protein of unknown function, DUF600; Region: DUF600; cl04640
224308002214	Uncharacterized conserved protein [Function unknown]; Region: COG5444
224308002215	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
224308002216	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308002217	hypothetical protein; Provisional; Region: PRK12378
224308002218	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308002219	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308002220	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
224308002221	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
224308002222	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
224308002223	NADP binding site [chemical binding]; other site
224308002224	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
224308002225	CotJB protein; Region: CotJB; pfam12652
224308002226	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
224308002227	dimanganese center [ion binding]; other site
224308002228	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308002229	Coenzyme A binding pocket [chemical binding]; other site
224308002230	YesK-like protein; Region: YesK; pfam14150
224308002231	Predicted integral membrane protein [Function unknown]; Region: COG5578
224308002232	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
224308002233	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
224308002234	dimerization interface [polypeptide binding]; other site
224308002235	Histidine kinase; Region: His_kinase; pfam06580
224308002236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308002237	ATP binding site [chemical binding]; other site
224308002238	Mg2+ binding site [ion binding]; other site
224308002239	G-X-G motif; other site
224308002240	Response regulator receiver domain; Region: Response_reg; pfam00072
224308002241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308002242	active site
224308002243	phosphorylation site [posttranslational modification]
224308002244	intermolecular recognition site; other site
224308002245	dimerization interface [polypeptide binding]; other site
224308002246	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308002247	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308002248	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224308002249	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
224308002250	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
224308002251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308002252	dimer interface [polypeptide binding]; other site
224308002253	conserved gate region; other site
224308002254	putative PBP binding loops; other site
224308002255	ABC-ATPase subunit interface; other site
224308002256	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224308002257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308002258	dimer interface [polypeptide binding]; other site
224308002259	conserved gate region; other site
224308002260	putative PBP binding loops; other site
224308002261	ABC-ATPase subunit interface; other site
224308002262	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
224308002263	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308002264	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308002265	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
224308002266	active site
224308002267	catalytic triad [active]
224308002268	Domain of unknown function (DUF1961); Region: DUF1961; pfam09224
224308002269	Predicted integral membrane protein [Function unknown]; Region: COG5578
224308002270	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
224308002271	metal binding site [ion binding]; metal-binding site
224308002272	active site
224308002273	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
224308002274	metal binding site [ion binding]; metal-binding site
224308002275	active site
224308002276	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
224308002277	active site
224308002278	catalytic triad [active]
224308002279	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
224308002280	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
224308002281	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
224308002282	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
224308002283	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224308002284	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
224308002285	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
224308002286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308002287	dimer interface [polypeptide binding]; other site
224308002288	putative PBP binding loops; other site
224308002289	ABC-ATPase subunit interface; other site
224308002290	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224308002291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308002292	dimer interface [polypeptide binding]; other site
224308002293	conserved gate region; other site
224308002294	putative PBP binding loops; other site
224308002295	ABC-ATPase subunit interface; other site
224308002296	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
224308002297	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
224308002298	NAD binding site [chemical binding]; other site
224308002299	sugar binding site [chemical binding]; other site
224308002300	divalent metal binding site [ion binding]; other site
224308002301	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
224308002302	dimer interface [polypeptide binding]; other site
224308002303	Predicted membrane protein [Function unknown]; Region: COG2323
224308002304	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
224308002305	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308002306	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
224308002307	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId: 11157946; Product type pr : regulator
224308002308	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId: 11157946; Product type pr : regulator
224308002309	Uncharacterized small protein [Function unknown]; Region: COG5583
224308002310	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
224308002311	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
224308002312	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224308002313	EamA-like transporter family; Region: EamA; pfam00892
224308002314	EamA-like transporter family; Region: EamA; pfam00892
224308002315	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308002316	MarR family; Region: MarR; pfam01047
224308002317	hypothetical protein; Provisional; Region: PRK06847
224308002318	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
224308002319	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
224308002320	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
224308002321	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
224308002322	Cytochrome P450; Region: p450; pfam00067
224308002323	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
224308002324	Flavodoxin; Region: Flavodoxin_1; pfam00258
224308002325	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
224308002326	FAD binding pocket [chemical binding]; other site
224308002327	FAD binding motif [chemical binding]; other site
224308002328	catalytic residues [active]
224308002329	NAD binding pocket [chemical binding]; other site
224308002330	phosphate binding motif [ion binding]; other site
224308002331	beta-alpha-beta structure motif; other site
224308002332	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
224308002333	Sulfatase; Region: Sulfatase; pfam00884
224308002334	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
224308002335	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
224308002336	substrate binding site; other site
224308002337	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
224308002338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224308002339	NAD(P) binding site [chemical binding]; other site
224308002340	active site
224308002341	Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407
224308002342	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224308002343	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308002344	active site
224308002345	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
224308002346	Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407
224308002347	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308002348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002349	putative substrate translocation pore; other site
224308002350	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
224308002351	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308002352	active site
224308002353	motif I; other site
224308002354	motif II; other site
224308002355	amino acid transporter; Region: 2A0306; TIGR00909
224308002356	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
224308002357	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
224308002358	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224308002359	NAD(P) binding site [chemical binding]; other site
224308002360	catalytic residues [active]
224308002361	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
224308002362	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308002363	dimer interface [polypeptide binding]; other site
224308002364	putative CheW interface [polypeptide binding]; other site
224308002365	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
224308002366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224308002367	Walker A/P-loop; other site
224308002368	ATP binding site [chemical binding]; other site
224308002369	Q-loop/lid; other site
224308002370	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308002371	ABC transporter signature motif; other site
224308002372	Walker B; other site
224308002373	D-loop; other site
224308002374	ABC transporter; Region: ABC_tran_2; pfam12848
224308002375	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308002376	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
224308002377	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224308002378	Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774
224308002379	DNA binding residues [nucleotide binding]
224308002380	putative dimer interface [polypeptide binding]; other site
224308002381	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224308002382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002383	putative substrate translocation pore; other site
224308002384	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
224308002385	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308002386	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308002387	ABC transporter; Region: ABC_tran_2; pfam12848
224308002388	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308002389	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
224308002390	DEAD-like helicases superfamily; Region: DEXDc; smart00487
224308002391	ATP binding site [chemical binding]; other site
224308002392	putative Mg++ binding site [ion binding]; other site
224308002393	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308002394	nucleotide binding region [chemical binding]; other site
224308002395	ATP-binding site [chemical binding]; other site
224308002396	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
224308002397	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
224308002398	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
224308002399	Prostaglandin dehydrogenases; Region: PGDH; cd05288
224308002400	NAD(P) binding site [chemical binding]; other site
224308002401	substrate binding site [chemical binding]; other site
224308002402	dimer interface [polypeptide binding]; other site
224308002403	H+ Antiporter protein; Region: 2A0121; TIGR00900
224308002404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002405	Uncharacterized conserved protein [Function unknown]; Region: COG1262
224308002406	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
224308002407	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
224308002408	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
224308002409	Walker A/P-loop; other site
224308002410	ATP binding site [chemical binding]; other site
224308002411	Q-loop/lid; other site
224308002412	ABC transporter signature motif; other site
224308002413	Walker B; other site
224308002414	D-loop; other site
224308002415	H-loop/switch region; other site
224308002416	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
224308002417	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308002418	ABC-ATPase subunit  interface; other site
224308002419	dimer interface [polypeptide binding]; other site
224308002420	putative PBP binding regions; other site
224308002421	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
224308002422	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308002423	ABC-ATPase subunit  interface; other site
224308002424	dimer interface [polypeptide binding]; other site
224308002425	putative PBP binding regions; other site
224308002426	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
224308002427	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
224308002428	siderophore binding site; other site
224308002429	Protein of unknown function (DUF3212); Region: DUF3212; pfam11486
224308002430	Heat induced stress protein YflT; Region: YflT; pfam11181
224308002431	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
224308002432	Amb_all domain; Region: Amb_all; smart00656
224308002433	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
224308002434	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
224308002435	transmembrane helices; other site
224308002436	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
224308002437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308002438	ATP binding site [chemical binding]; other site
224308002439	Mg2+ binding site [ion binding]; other site
224308002440	G-X-G motif; other site
224308002441	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
224308002442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308002443	active site
224308002444	phosphorylation site [posttranslational modification]
224308002445	intermolecular recognition site; other site
224308002446	dimerization interface [polypeptide binding]; other site
224308002447	Transcriptional regulator; Region: CitT; pfam12431
224308002448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
224308002449	citrate transporter, CitMHS family; Region: citMHS; TIGR00784
224308002450	Citrate transporter; Region: CitMHS; pfam03600
224308002451	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224308002452	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
224308002453	active site
224308002454	dimer interface [polypeptide binding]; other site
224308002455	acylphosphatase; Provisional; Region: PRK14420
224308002456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
224308002457	MOSC domain; Region: MOSC; pfam03473
224308002458	3-alpha domain; Region: 3-alpha; pfam03475
224308002459	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
224308002460	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
224308002461	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
224308002462	active site
224308002463	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
224308002464	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
224308002465	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224308002466	active site turn [active]
224308002467	phosphorylation site [posttranslational modification]
224308002468	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
224308002469	Sulfatase; Region: Sulfatase; pfam00884
224308002470	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
224308002471	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
224308002472	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
224308002473	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
224308002474	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
224308002475	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
224308002476	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
224308002477	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
224308002478	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224308002479	active site turn [active]
224308002480	phosphorylation site [posttranslational modification]
224308002481	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
224308002482	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
224308002483	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
224308002484	Ca binding site [ion binding]; other site
224308002485	active site
224308002486	catalytic site [active]
224308002487	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
224308002488	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308002489	DNA-binding site [nucleotide binding]; DNA binding site
224308002490	UTRA domain; Region: UTRA; pfam07702
224308002491	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
224308002492	dimer interface [polypeptide binding]; other site
224308002493	FMN binding site [chemical binding]; other site
224308002494	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419
224308002495	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
224308002496	active site
224308002497	metal binding site [ion binding]; metal-binding site
224308002498	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
224308002499	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
224308002500	active site
224308002501	metal binding site [ion binding]; metal-binding site
224308002502	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
224308002503	intracellular protease, PfpI family; Region: PfpI; TIGR01382
224308002504	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
224308002505	proposed catalytic triad [active]
224308002506	conserved cys residue [active]
224308002507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002508	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308002509	putative substrate translocation pore; other site
224308002510	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
224308002511	Low molecular weight phosphatase family; Region: LMWPc; cd00115
224308002512	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
224308002513	active site
224308002514	YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765
224308002515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002516	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308002517	putative substrate translocation pore; other site
224308002518	calcium/proton exchanger (cax); Region: cax; TIGR00378
224308002519	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
224308002520	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
224308002521	YfkD-like protein; Region: YfkD; pfam14167
224308002522	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
224308002523	Mechanosensitive ion channel; Region: MS_channel; pfam00924
224308002524	Radical SAM superfamily; Region: Radical_SAM; pfam04055
224308002525	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308002526	FeS/SAM binding site; other site
224308002527	YfkB-like domain; Region: YfkB; pfam08756
224308002528	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
224308002529	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
224308002530	NodB motif; other site
224308002531	active site
224308002532	catalytic site [active]
224308002533	Cd binding site [ion binding]; other site
224308002534	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
224308002535	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
224308002536	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
224308002537	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
224308002538	oligomer interface [polypeptide binding]; other site
224308002539	metal binding site [ion binding]; metal-binding site
224308002540	metal binding site [ion binding]; metal-binding site
224308002541	putative Cl binding site [ion binding]; other site
224308002542	aspartate ring; other site
224308002543	basic sphincter; other site
224308002544	hydrophobic gate; other site
224308002545	periplasmic entrance; other site
224308002546	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
224308002547	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224308002548	minor groove reading motif; other site
224308002549	helix-hairpin-helix signature motif; other site
224308002550	substrate binding pocket [chemical binding]; other site
224308002551	active site
224308002552	TRAM domain; Region: TRAM; pfam01938
224308002553	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
224308002554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308002555	S-adenosylmethionine binding site [chemical binding]; other site
224308002556	YfzA-like protein; Region: YfzA; pfam14118
224308002557	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
224308002558	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
224308002559	FMN binding site [chemical binding]; other site
224308002560	active site
224308002561	catalytic residues [active]
224308002562	substrate binding site [chemical binding]; other site
224308002563	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
224308002564	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
224308002565	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
224308002566	tetramer interface [polypeptide binding]; other site
224308002567	TPP-binding site [chemical binding]; other site
224308002568	heterodimer interface [polypeptide binding]; other site
224308002569	phosphorylation loop region [posttranslational modification]
224308002570	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
224308002571	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
224308002572	alpha subunit interface [polypeptide binding]; other site
224308002573	TPP binding site [chemical binding]; other site
224308002574	heterodimer interface [polypeptide binding]; other site
224308002575	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224308002576	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
224308002577	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224308002578	E3 interaction surface; other site
224308002579	lipoyl attachment site [posttranslational modification]; other site
224308002580	e3 binding domain; Region: E3_binding; pfam02817
224308002581	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
224308002582	dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912
224308002583	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308002584	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
224308002585	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
224308002586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308002587	Walker A motif; other site
224308002588	ATP binding site [chemical binding]; other site
224308002589	Walker B motif; other site
224308002590	arginine finger; other site
224308002591	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
224308002592	acid-soluble spore protein H; Provisional; Region: sspH; PRK03174
224308002593	hypothetical protein; Provisional; Region: PRK02237
224308002594	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
224308002595	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
224308002596	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
224308002597	NAD binding site [chemical binding]; other site
224308002598	sugar binding site [chemical binding]; other site
224308002599	divalent metal binding site [ion binding]; other site
224308002600	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
224308002601	dimer interface [polypeptide binding]; other site
224308002602	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
224308002603	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
224308002604	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
224308002605	putative active site [active]
224308002606	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
224308002607	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
224308002608	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224308002609	active site turn [active]
224308002610	phosphorylation site [posttranslational modification]
224308002611	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224308002612	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308002613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224308002614	Walker A/P-loop; other site
224308002615	ATP binding site [chemical binding]; other site
224308002616	Q-loop/lid; other site
224308002617	ABC transporter signature motif; other site
224308002618	Walker B; other site
224308002619	D-loop; other site
224308002620	H-loop/switch region; other site
224308002621	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224308002622	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308002623	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
224308002624	Walker A/P-loop; other site
224308002625	ATP binding site [chemical binding]; other site
224308002626	Q-loop/lid; other site
224308002627	ABC transporter signature motif; other site
224308002628	Walker B; other site
224308002629	D-loop; other site
224308002630	H-loop/switch region; other site
224308002631	Predicted membrane protein [Function unknown]; Region: COG2259
224308002632	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
224308002633	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
224308002634	putative metal binding site [ion binding]; other site
224308002635	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
224308002636	active site
224308002637	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
224308002638	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
224308002639	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308002640	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308002641	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
224308002642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002643	putative substrate translocation pore; other site
224308002644	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
224308002645	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
224308002646	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224308002647	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
224308002648	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
224308002649	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
224308002650	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
224308002651	Histidine kinase; Region: HisKA_3; pfam07730
224308002652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308002653	ATP binding site [chemical binding]; other site
224308002654	Mg2+ binding site [ion binding]; other site
224308002655	G-X-G motif; other site
224308002656	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308002657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308002658	active site
224308002659	phosphorylation site [posttranslational modification]
224308002660	intermolecular recognition site; other site
224308002661	dimerization interface [polypeptide binding]; other site
224308002662	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308002663	DNA binding residues [nucleotide binding]
224308002664	dimerization interface [polypeptide binding]; other site
224308002665	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
224308002666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224308002667	Walker A/P-loop; other site
224308002668	ATP binding site [chemical binding]; other site
224308002669	Q-loop/lid; other site
224308002670	ABC transporter signature motif; other site
224308002671	Walker B; other site
224308002672	D-loop; other site
224308002673	H-loop/switch region; other site
224308002674	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
224308002675	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
224308002676	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
224308002677	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
224308002678	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
224308002679	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
224308002680	Predicted transcriptional regulators [Transcription]; Region: COG1695
224308002681	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
224308002682	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
224308002683	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
224308002684	Lipase (class 2); Region: Lipase_2; pfam01674
224308002685	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
224308002686	Acyltransferase family; Region: Acyl_transf_3; pfam01757
224308002687	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308002688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308002689	H+ Antiporter protein; Region: 2A0121; TIGR00900
224308002690	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002691	putative substrate translocation pore; other site
224308002692	metal-dependent hydrolase; Provisional; Region: PRK13291
224308002693	DinB superfamily; Region: DinB_2; pfam12867
224308002694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002695	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308002696	putative substrate translocation pore; other site
224308002697	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308002698	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308002699	putative Zn2+ binding site [ion binding]; other site
224308002700	putative DNA binding site [nucleotide binding]; other site
224308002701	Predicted integral membrane protein [Function unknown]; Region: COG0392
224308002702	Uncharacterized conserved protein [Function unknown]; Region: COG2898
224308002703	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
224308002704	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
224308002705	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
224308002706	siderophore binding site; other site
224308002707	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
224308002708	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308002709	ABC-ATPase subunit  interface; other site
224308002710	dimer interface [polypeptide binding]; other site
224308002711	putative PBP binding regions; other site
224308002712	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
224308002713	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308002714	ABC-ATPase subunit  interface; other site
224308002715	dimer interface [polypeptide binding]; other site
224308002716	putative PBP binding regions; other site
224308002717	phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654
224308002718	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
224308002719	putative FMN binding site [chemical binding]; other site
224308002720	YfhD-like protein; Region: YfhD; pfam14151
224308002721	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
224308002722	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
224308002723	putative NAD(P) binding site [chemical binding]; other site
224308002724	putative active site [active]
224308002725	recombination regulator RecX; Provisional; Region: recX; PRK14135
224308002726	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
224308002727	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224308002728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002729	putative substrate translocation pore; other site
224308002730	Small acid-soluble spore protein K family; Region: SspK; pfam08176
224308002731	WVELL protein; Region: WVELL; pfam14043
224308002732	Bacterial SH3 domain; Region: SH3_3; pfam08239
224308002733	Bacterial SH3 domain; Region: SH3_3; cl17532
224308002734	Predicted integral membrane protein [Function unknown]; Region: COG5658
224308002735	SdpI/YhfL protein family; Region: SdpI; pfam13630
224308002736	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308002737	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
224308002738	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
224308002739	catalytic site [active]
224308002740	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
224308002741	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
224308002742	Ligand binding site; other site
224308002743	Putative Catalytic site; other site
224308002744	DXD motif; other site
224308002745	Predicted membrane protein [Function unknown]; Region: COG4485
224308002746	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
224308002747	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
224308002748	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224308002749	minor groove reading motif; other site
224308002750	helix-hairpin-helix signature motif; other site
224308002751	substrate binding pocket [chemical binding]; other site
224308002752	active site
224308002753	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
224308002754	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
224308002755	DNA binding and oxoG recognition site [nucleotide binding]
224308002756	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
224308002757	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
224308002758	putative NAD(P) binding site [chemical binding]; other site
224308002759	active site
224308002760	YgaB-like protein; Region: YgaB; pfam14182
224308002761	hypothetical protein; Provisional; Region: PRK13662
224308002762	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224308002763	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308002764	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
224308002765	Walker A/P-loop; other site
224308002766	ATP binding site [chemical binding]; other site
224308002767	Q-loop/lid; other site
224308002768	ABC transporter signature motif; other site
224308002769	Walker B; other site
224308002770	D-loop; other site
224308002771	H-loop/switch region; other site
224308002772	Predicted membrane protein [Function unknown]; Region: COG4129
224308002773	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
224308002774	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
224308002775	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224308002776	inhibitor-cofactor binding pocket; inhibition site
224308002777	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308002778	catalytic residue [active]
224308002779	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
224308002780	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
224308002781	catalytic triad [active]
224308002782	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
224308002783	metal binding site 2 [ion binding]; metal-binding site
224308002784	putative DNA binding helix; other site
224308002785	metal binding site 1 [ion binding]; metal-binding site
224308002786	dimer interface [polypeptide binding]; other site
224308002787	structural Zn2+ binding site [ion binding]; other site
224308002788	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
224308002789	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
224308002790	SpoOM protein; Region: Spo0M; pfam07070
224308002791	Coat F domain; Region: Coat_F; pfam07875
224308002792	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
224308002793	active site pocket [active]
224308002794	oxyanion hole [active]
224308002795	catalytic triad [active]
224308002796	active site nucleophile [active]
224308002797	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
224308002798	ThiC-associated domain; Region: ThiC-associated; pfam13667
224308002799	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
224308002800	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
224308002801	FAD binding domain; Region: FAD_binding_4; pfam01565
224308002802	Berberine and berberine like; Region: BBE; pfam08031
224308002803	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
224308002804	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
224308002805	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
224308002806	tetramer interface [polypeptide binding]; other site
224308002807	heme binding pocket [chemical binding]; other site
224308002808	NADPH binding site [chemical binding]; other site
224308002809	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
224308002810	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
224308002811	Walker A/P-loop; other site
224308002812	ATP binding site [chemical binding]; other site
224308002813	Q-loop/lid; other site
224308002814	ABC transporter signature motif; other site
224308002815	Walker B; other site
224308002816	D-loop; other site
224308002817	H-loop/switch region; other site
224308002818	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
224308002819	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224308002820	substrate binding pocket [chemical binding]; other site
224308002821	membrane-bound complex binding site; other site
224308002822	hinge residues; other site
224308002823	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
224308002824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308002825	dimer interface [polypeptide binding]; other site
224308002826	conserved gate region; other site
224308002827	putative PBP binding loops; other site
224308002828	ABC-ATPase subunit interface; other site
224308002829	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
224308002830	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
224308002831	active site
224308002832	dimer interface [polypeptide binding]; other site
224308002833	non-prolyl cis peptide bond; other site
224308002834	insertion regions; other site
224308002835	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
224308002836	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308002837	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308002838	non-specific DNA binding site [nucleotide binding]; other site
224308002839	salt bridge; other site
224308002840	sequence-specific DNA binding site [nucleotide binding]; other site
224308002841	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
224308002842	epoxyqueuosine reductase; Region: TIGR00276
224308002843	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
224308002844	Putative amidase domain; Region: Amidase_6; pfam12671
224308002845	tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185
224308002846	Protein of unknown function (DUF4004); Region: DUF4004; pfam13171
224308002847	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
224308002848	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
224308002849	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
224308002850	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
224308002851	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
224308002852	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
224308002853	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308002854	MarR family; Region: MarR; pfam01047
224308002855	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
224308002856	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224308002857	carboxyltransferase (CT) interaction site; other site
224308002858	biotinylation site [posttranslational modification]; other site
224308002859	HlyD family secretion protein; Region: HlyD_3; pfam13437
224308002860	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
224308002861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002862	putative substrate translocation pore; other site
224308002863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308002864	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
224308002865	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
224308002866	Predicted transcriptional regulators [Transcription]; Region: COG1725
224308002867	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308002868	DNA-binding site [nucleotide binding]; DNA binding site
224308002869	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
224308002870	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
224308002871	Walker A/P-loop; other site
224308002872	ATP binding site [chemical binding]; other site
224308002873	Q-loop/lid; other site
224308002874	ABC transporter signature motif; other site
224308002875	Walker B; other site
224308002876	D-loop; other site
224308002877	H-loop/switch region; other site
224308002878	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
224308002879	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224308002880	Walker A/P-loop; other site
224308002881	ATP binding site [chemical binding]; other site
224308002882	Q-loop/lid; other site
224308002883	ABC transporter signature motif; other site
224308002884	Walker B; other site
224308002885	D-loop; other site
224308002886	H-loop/switch region; other site
224308002887	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
224308002888	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
224308002889	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
224308002890	DNA-binding site [nucleotide binding]; DNA binding site
224308002891	RNA-binding motif; other site
224308002892	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
224308002893	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
224308002894	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
224308002895	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
224308002896	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224308002897	metal binding site [ion binding]; metal-binding site
224308002898	active site
224308002899	I-site; other site
224308002900	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
224308002901	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
224308002902	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
224308002903	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
224308002904	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
224308002905	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
224308002906	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
224308002907	generic binding surface II; other site
224308002908	generic binding surface I; other site
224308002909	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
224308002910	generic binding surface II; other site
224308002911	generic binding surface I; other site
224308002912	Staphylococcal nuclease homologues; Region: SNc; smart00318
224308002913	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
224308002914	Catalytic site; other site
224308002915	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
224308002916	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
224308002917	putative active site [active]
224308002918	putative metal binding site [ion binding]; other site
224308002919	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
224308002920	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
224308002921	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
224308002922	active site
224308002923	catalytic site [active]
224308002924	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
224308002925	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308002926	RNA binding surface [nucleotide binding]; other site
224308002927	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
224308002928	active site
224308002929	FOG: CBS domain [General function prediction only]; Region: COG0517
224308002930	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
224308002931	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
224308002932	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308002933	motif II; other site
224308002934	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308002935	Coenzyme A binding pocket [chemical binding]; other site
224308002936	Predicted amidohydrolase [General function prediction only]; Region: COG0388
224308002937	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
224308002938	putative active site [active]
224308002939	catalytic triad [active]
224308002940	putative dimer interface [polypeptide binding]; other site
224308002941	Evidence 5: No homology to any previously reported sequences
224308002942	aminotransferase; Validated; Region: PRK07678
224308002943	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224308002944	inhibitor-cofactor binding pocket; inhibition site
224308002945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308002946	catalytic residue [active]
224308002947	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
224308002948	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
224308002949	amphipathic channel; other site
224308002950	Asn-Pro-Ala signature motifs; other site
224308002951	glycerol kinase; Provisional; Region: glpK; PRK00047
224308002952	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
224308002953	N- and C-terminal domain interface [polypeptide binding]; other site
224308002954	active site
224308002955	MgATP binding site [chemical binding]; other site
224308002956	catalytic site [active]
224308002957	metal binding site [ion binding]; metal-binding site
224308002958	glycerol binding site [chemical binding]; other site
224308002959	homotetramer interface [polypeptide binding]; other site
224308002960	homodimer interface [polypeptide binding]; other site
224308002961	FBP binding site [chemical binding]; other site
224308002962	protein IIAGlc interface [polypeptide binding]; other site
224308002963	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
224308002964	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
224308002965	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
224308002966	active site
224308002967	substrate binding site [chemical binding]; other site
224308002968	metal binding site [ion binding]; metal-binding site
224308002969	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
224308002970	GAF domain; Region: GAF; pfam01590
224308002971	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
224308002972	Histidine kinase; Region: HisKA_3; pfam07730
224308002973	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308002974	ATP binding site [chemical binding]; other site
224308002975	Mg2+ binding site [ion binding]; other site
224308002976	G-X-G motif; other site
224308002977	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308002978	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308002979	active site
224308002980	phosphorylation site [posttranslational modification]
224308002981	intermolecular recognition site; other site
224308002982	dimerization interface [polypeptide binding]; other site
224308002983	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308002984	DNA binding residues [nucleotide binding]
224308002985	dimerization interface [polypeptide binding]; other site
224308002986	Predicted flavoprotein [General function prediction only]; Region: COG0431
224308002987	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
224308002988	YhdB-like protein; Region: YhdB; pfam14148
224308002989	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
224308002990	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308002991	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308002992	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308002993	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308002994	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308002995	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
224308002996	NlpC/P60 family; Region: NLPC_P60; pfam00877
224308002997	Transcriptional regulator; Region: Rrf2; cl17282
224308002998	Rrf2 family protein; Region: rrf2_super; TIGR00738
224308002999	Conserved TM helix; Region: TM_helix; pfam05552
224308003000	Conserved TM helix; Region: TM_helix; pfam05552
224308003001	Conserved TM helix; Region: TM_helix; pfam05552
224308003002	Conserved TM helix; Region: TM_helix; pfam05552
224308003003	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
224308003004	SpoVR like protein; Region: SpoVR; pfam04293
224308003005	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
224308003006	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
224308003007	dimer interface [polypeptide binding]; other site
224308003008	active site
224308003009	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308003010	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308003011	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308003012	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
224308003013	NlpC/P60 family; Region: NLPC_P60; pfam00877
224308003014	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308003015	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308003016	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308003017	dimerization interface [polypeptide binding]; other site
224308003018	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
224308003019	dimer interface [polypeptide binding]; other site
224308003020	Citrate synthase; Region: Citrate_synt; pfam00285
224308003021	active site
224308003022	citrylCoA binding site [chemical binding]; other site
224308003023	oxalacetate/citrate binding site [chemical binding]; other site
224308003024	coenzyme A binding site [chemical binding]; other site
224308003025	catalytic triad [active]
224308003026	short chain dehydrogenase; Provisional; Region: PRK06701
224308003027	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
224308003028	NAD binding site [chemical binding]; other site
224308003029	metal binding site [ion binding]; metal-binding site
224308003030	active site
224308003031	amino acid transporter; Region: 2A0306; TIGR00909
224308003032	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
224308003033	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
224308003034	Na2 binding site [ion binding]; other site
224308003035	putative substrate binding site 1 [chemical binding]; other site
224308003036	Na binding site 1 [ion binding]; other site
224308003037	putative substrate binding site 2 [chemical binding]; other site
224308003038	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
224308003039	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308003040	DNA-binding site [nucleotide binding]; DNA binding site
224308003041	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308003042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308003043	homodimer interface [polypeptide binding]; other site
224308003044	catalytic residue [active]
224308003045	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
224308003046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308003047	Coenzyme A binding pocket [chemical binding]; other site
224308003048	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
224308003049	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
224308003050	RNA polymerase sigma factor SigM; Provisional; Region: PRK09644
224308003051	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308003052	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308003053	DNA binding residues [nucleotide binding]
224308003054	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224308003055	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
224308003056	active site
224308003057	catalytic tetrad [active]
224308003058	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
224308003059	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
224308003060	putative acyl-acceptor binding pocket; other site
224308003061	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
224308003062	Domain of unknown function DUF21; Region: DUF21; pfam01595
224308003063	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224308003064	Transporter associated domain; Region: CorC_HlyC; smart01091
224308003065	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
224308003066	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
224308003067	DNA binding residues [nucleotide binding]
224308003068	putative dimer interface [polypeptide binding]; other site
224308003069	aspartate aminotransferase; Provisional; Region: PRK06836
224308003070	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308003071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308003072	homodimer interface [polypeptide binding]; other site
224308003073	catalytic residue [active]
224308003074	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
224308003075	Domain of unknown function DUF21; Region: DUF21; pfam01595
224308003076	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224308003077	Transporter associated domain; Region: CorC_HlyC; smart01091
224308003078	camphor resistance protein CrcB; Provisional; Region: PRK14213
224308003079	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
224308003080	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
224308003081	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
224308003082	active site
224308003083	catalytic site [active]
224308003084	metal binding site [ion binding]; metal-binding site
224308003085	dimer interface [polypeptide binding]; other site
224308003086	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
224308003087	Mechanosensitive ion channel; Region: MS_channel; pfam00924
224308003088	NAD-dependent deacetylase; Provisional; Region: PRK00481
224308003089	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
224308003090	NAD+ binding site [chemical binding]; other site
224308003091	substrate binding site [chemical binding]; other site
224308003092	Zn binding site [ion binding]; other site
224308003093	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
224308003094	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
224308003095	NodB motif; other site
224308003096	active site
224308003097	catalytic site [active]
224308003098	Zn binding site [ion binding]; other site
224308003099	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
224308003100	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
224308003101	homodimer interface [polypeptide binding]; other site
224308003102	substrate-cofactor binding pocket; other site
224308003103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308003104	catalytic residue [active]
224308003105	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
224308003106	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224308003107	Ligand Binding Site [chemical binding]; other site
224308003108	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308003109	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
224308003110	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224308003111	Walker A/P-loop; other site
224308003112	ATP binding site [chemical binding]; other site
224308003113	Q-loop/lid; other site
224308003114	ABC transporter signature motif; other site
224308003115	Walker B; other site
224308003116	D-loop; other site
224308003117	H-loop/switch region; other site
224308003118	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224308003119	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308003120	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
224308003121	Walker A/P-loop; other site
224308003122	ATP binding site [chemical binding]; other site
224308003123	Q-loop/lid; other site
224308003124	ABC transporter signature motif; other site
224308003125	Walker B; other site
224308003126	D-loop; other site
224308003127	H-loop/switch region; other site
224308003128	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
224308003129	NADH(P)-binding; Region: NAD_binding_10; pfam13460
224308003130	NAD binding site [chemical binding]; other site
224308003131	substrate binding site [chemical binding]; other site
224308003132	putative active site [active]
224308003133	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
224308003134	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
224308003135	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
224308003136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
224308003137	hypothetical protein; Provisional; Region: PRK13676
224308003138	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
224308003139	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
224308003140	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308003141	active site
224308003142	motif I; other site
224308003143	motif II; other site
224308003144	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
224308003145	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
224308003146	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308003147	FeS/SAM binding site; other site
224308003148	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
224308003149	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
224308003150	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
224308003151	TrkA-C domain; Region: TrkA_C; pfam02080
224308003152	enoyl-CoA hydratase; Provisional; Region: PRK07659
224308003153	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224308003154	substrate binding site [chemical binding]; other site
224308003155	oxyanion hole (OAH) forming residues; other site
224308003156	trimer interface [polypeptide binding]; other site
224308003157	YhzD-like protein; Region: YhzD; pfam14120
224308003158	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
224308003159	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
224308003160	Walker A/P-loop; other site
224308003161	ATP binding site [chemical binding]; other site
224308003162	Q-loop/lid; other site
224308003163	ABC transporter signature motif; other site
224308003164	Walker B; other site
224308003165	D-loop; other site
224308003166	H-loop/switch region; other site
224308003167	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
224308003168	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
224308003169	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
224308003170	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
224308003171	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
224308003172	active site
224308003173	metal binding site [ion binding]; metal-binding site
224308003174	DNA binding site [nucleotide binding]
224308003175	Uncharacterized conserved protein [Function unknown]; Region: COG4717
224308003176	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
224308003177	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
224308003178	generic binding surface II; other site
224308003179	generic binding surface I; other site
224308003180	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224308003181	Zn2+ binding site [ion binding]; other site
224308003182	Mg2+ binding site [ion binding]; other site
224308003183	Sporulation protein YhaL; Region: Spore_YhaL; pfam14147
224308003184	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
224308003185	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
224308003186	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
224308003187	Protein of unknown function (DUF1878); Region: DUF1878; pfam08963
224308003188	transcriptional regulator Hpr; Provisional; Region: PRK13777
224308003189	MarR family; Region: MarR; pfam01047
224308003190	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
224308003191	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
224308003192	homodimer interface [polypeptide binding]; other site
224308003193	substrate-cofactor binding pocket; other site
224308003194	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308003195	catalytic residue [active]
224308003196	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
224308003197	HIT family signature motif; other site
224308003198	catalytic residue [active]
224308003199	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
224308003200	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
224308003201	Walker A/P-loop; other site
224308003202	ATP binding site [chemical binding]; other site
224308003203	Q-loop/lid; other site
224308003204	ABC transporter signature motif; other site
224308003205	Walker B; other site
224308003206	D-loop; other site
224308003207	H-loop/switch region; other site
224308003208	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
224308003209	EcsC protein family; Region: EcsC; pfam12787
224308003210	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
224308003211	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
224308003212	metal binding site [ion binding]; metal-binding site
224308003213	dimer interface [polypeptide binding]; other site
224308003214	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
224308003215	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
224308003216	Transglycosylase; Region: Transgly; pfam00912
224308003217	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224308003218	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
224308003219	substrate binding site [chemical binding]; other site
224308003220	active site
224308003221	ferrochelatase; Provisional; Region: PRK12435
224308003222	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
224308003223	C-terminal domain interface [polypeptide binding]; other site
224308003224	active site
224308003225	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
224308003226	active site
224308003227	N-terminal domain interface [polypeptide binding]; other site
224308003228	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
224308003229	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
224308003230	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308003231	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308003232	Predicted membrane protein [Function unknown]; Region: COG1511
224308003233	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
224308003234	Pex19 protein family; Region: Pex19; pfam04614
224308003235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308003236	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
224308003237	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
224308003238	dimer interface [polypeptide binding]; other site
224308003239	active site
224308003240	CoA binding pocket [chemical binding]; other site
224308003241	Predicted membrane protein [Function unknown]; Region: COG4377
224308003242	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
224308003243	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
224308003244	putative oligomer interface [polypeptide binding]; other site
224308003245	putative active site [active]
224308003246	metal binding site [ion binding]; metal-binding site
224308003247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4405
224308003248	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
224308003249	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
224308003250	YhfH-like protein; Region: YhfH; pfam14149
224308003251	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
224308003252	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
224308003253	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
224308003254	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
224308003255	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
224308003256	NADH(P)-binding; Region: NAD_binding_10; pfam13460
224308003257	NAD(P) binding site [chemical binding]; other site
224308003258	putative active site [active]
224308003259	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
224308003260	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
224308003261	acyl-activating enzyme (AAE) consensus motif; other site
224308003262	putative AMP binding site [chemical binding]; other site
224308003263	putative active site [active]
224308003264	putative CoA binding site [chemical binding]; other site
224308003265	Peptidase family M48; Region: Peptidase_M48; pfam01435
224308003266	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
224308003267	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
224308003268	active site
224308003269	catalytic residues [active]
224308003270	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
224308003271	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308003272	Coenzyme A binding pocket [chemical binding]; other site
224308003273	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
224308003274	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
224308003275	putative NADP binding site [chemical binding]; other site
224308003276	putative dimer interface [polypeptide binding]; other site
224308003277	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
224308003278	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
224308003279	siderophore binding site; other site
224308003280	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
224308003281	catalytic core [active]
224308003282	acetyl-CoA acetyltransferase; Provisional; Region: PRK06690
224308003283	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
224308003284	dimer interface [polypeptide binding]; other site
224308003285	active site
224308003286	acyl-CoA synthetase; Validated; Region: PRK07638
224308003287	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
224308003288	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
224308003289	acyl-activating enzyme (AAE) consensus motif; other site
224308003290	acyl-activating enzyme (AAE) consensus motif; other site
224308003291	AMP binding site [chemical binding]; other site
224308003292	active site
224308003293	CoA binding site [chemical binding]; other site
224308003294	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
224308003295	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
224308003296	heme-binding site [chemical binding]; other site
224308003297	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
224308003298	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308003299	dimer interface [polypeptide binding]; other site
224308003300	putative CheW interface [polypeptide binding]; other site
224308003301	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
224308003302	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
224308003303	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
224308003304	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
224308003305	[2Fe-2S] cluster binding site [ion binding]; other site
224308003306	short chain dehydrogenase; Provisional; Region: PRK06701
224308003307	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
224308003308	NAD binding site [chemical binding]; other site
224308003309	metal binding site [ion binding]; metal-binding site
224308003310	active site
224308003311	IDEAL domain; Region: IDEAL; pfam08858
224308003312	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
224308003313	oxidoreductase; Provisional; Region: PRK07985
224308003314	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
224308003315	NAD binding site [chemical binding]; other site
224308003316	metal binding site [ion binding]; metal-binding site
224308003317	active site
224308003318	Excalibur calcium-binding domain; Region: Excalibur; cl05460
224308003319	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
224308003320	Na binding site [ion binding]; other site
224308003321	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
224308003322	Uncharacterized conserved protein [Function unknown]; Region: COG0398
224308003323	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
224308003324	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
224308003325	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224308003326	Catalytic site [active]
224308003327	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
224308003328	hypothetical protein; Provisional; Region: PRK08244
224308003329	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
224308003330	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308003331	MarR family; Region: MarR; pfam01047
224308003332	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
224308003333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308003334	putative substrate translocation pore; other site
224308003335	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224308003336	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
224308003337	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
224308003338	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
224308003339	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308003340	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
224308003341	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
224308003342	inhibitor-cofactor binding pocket; inhibition site
224308003343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308003344	catalytic residue [active]
224308003345	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308003346	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308003347	DNA binding site [nucleotide binding]
224308003348	domain linker motif; other site
224308003349	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
224308003350	putative dimerization interface [polypeptide binding]; other site
224308003351	putative ligand binding site [chemical binding]; other site
224308003352	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
224308003353	Putative ammonia monooxygenase; Region: AmoA; pfam05145
224308003354	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
224308003355	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308003356	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308003357	putative substrate translocation pore; other site
224308003358	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
224308003359	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
224308003360	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
224308003361	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
224308003362	dimerization interface [polypeptide binding]; other site
224308003363	Uncharacterized conserved protein [Function unknown]; Region: COG1633
224308003364	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
224308003365	dinuclear metal binding motif [ion binding]; other site
224308003366	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
224308003367	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
224308003368	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
224308003369	Part of AAA domain; Region: AAA_19; pfam13245
224308003370	Family description; Region: UvrD_C_2; pfam13538
224308003371	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
224308003372	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
224308003373	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
224308003374	active site
224308003375	metal binding site [ion binding]; metal-binding site
224308003376	DNA binding site [nucleotide binding]
224308003377	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
224308003378	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
224308003379	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
224308003380	Walker A/P-loop; other site
224308003381	ATP binding site [chemical binding]; other site
224308003382	Q-loop/lid; other site
224308003383	ABC transporter signature motif; other site
224308003384	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
224308003385	ABC transporter signature motif; other site
224308003386	Walker B; other site
224308003387	D-loop; other site
224308003388	H-loop/switch region; other site
224308003389	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
224308003390	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
224308003391	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
224308003392	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
224308003393	Spore germination protein GerPC; Region: GerPC; pfam10737
224308003394	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
224308003395	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
224308003396	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
224308003397	CotH protein; Region: CotH; pfam08757
224308003398	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
224308003399	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
224308003400	hypothetical protein; Provisional; Region: PRK13673
224308003401	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
224308003402	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
224308003403	active site
224308003404	catalytic triad [active]
224308003405	Protein of unknown function (DUF2777); Region: DUF2777; pfam10949
224308003406	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
224308003407	active site
224308003408	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
224308003409	dimer interface [polypeptide binding]; other site
224308003410	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
224308003411	Ligand Binding Site [chemical binding]; other site
224308003412	Molecular Tunnel; other site
224308003413	DinB family; Region: DinB; cl17821
224308003414	DinB superfamily; Region: DinB_2; pfam12867
224308003415	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
224308003416	substrate binding pocket [chemical binding]; other site
224308003417	aspartate-rich region 2; other site
224308003418	substrate-Mg2+ binding site; other site
224308003419	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
224308003420	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
224308003421	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
224308003422	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308003423	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308003424	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308003425	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308003426	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308003427	DNA binding site [nucleotide binding]
224308003428	domain linker motif; other site
224308003429	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
224308003430	dimerization interface [polypeptide binding]; other site
224308003431	ligand binding site [chemical binding]; other site
224308003432	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224308003433	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
224308003434	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
224308003435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
224308003436	Lysine efflux permease [General function prediction only]; Region: COG1279
224308003437	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
224308003438	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308003439	DNA-binding site [nucleotide binding]; DNA binding site
224308003440	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308003441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308003442	homodimer interface [polypeptide binding]; other site
224308003443	catalytic residue [active]
224308003444	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
224308003445	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
224308003446	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
224308003447	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308003448	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
224308003449	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
224308003450	ligand-binding site [chemical binding]; other site
224308003451	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
224308003452	ATP-sulfurylase; Region: ATPS; cd00517
224308003453	active site
224308003454	HXXH motif; other site
224308003455	flexible loop; other site
224308003456	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
224308003457	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
224308003458	Active Sites [active]
224308003459	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
224308003460	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
224308003461	(2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM    biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809
224308003462	Uncharacterized conserved protein [Function unknown]; Region: COG1284
224308003463	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308003464	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
224308003465	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
224308003466	active site pocket [active]
224308003467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308003468	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308003469	putative substrate translocation pore; other site
224308003470	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
224308003471	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308003472	Coenzyme A binding pocket [chemical binding]; other site
224308003473	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
224308003474	Coenzyme A binding pocket [chemical binding]; other site
224308003475	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
224308003476	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
224308003477	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
224308003478	FAD binding site [chemical binding]; other site
224308003479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
224308003480	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
224308003481	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
224308003482	S1 domain; Region: S1_2; pfam13509
224308003483	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
224308003484	RNA binding site [nucleotide binding]; other site
224308003485	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
224308003486	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
224308003487	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
224308003488	Predicted transcriptional regulators [Transcription]; Region: COG1695
224308003489	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
224308003490	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
224308003491	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
224308003492	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
224308003493	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
224308003494	active site
224308003495	Zn binding site [ion binding]; other site
224308003496	EDD domain protein, DegV family; Region: DegV; TIGR00762
224308003497	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
224308003498	Uncharacterized conserved protein [Function unknown]; Region: COG1284
224308003499	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308003500	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308003501	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
224308003502	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
224308003503	Protein of unknown function (DUF3813); Region: DUF3813; pfam12758
224308003504	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
224308003505	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308003506	motif II; other site
224308003507	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308003508	esterase; Provisional; Region: PRK10566
224308003509	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
224308003510	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
224308003511	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
224308003512	FAD binding domain; Region: FAD_binding_4; pfam01565
224308003513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308003514	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308003515	putative substrate translocation pore; other site
224308003516	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
224308003517	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
224308003518	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
224308003519	heterotetramer interface [polypeptide binding]; other site
224308003520	active site pocket [active]
224308003521	cleavage site
224308003522	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
224308003523	nucleotide binding site [chemical binding]; other site
224308003524	N-acetyl-L-glutamate binding site [chemical binding]; other site
224308003525	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
224308003526	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224308003527	inhibitor-cofactor binding pocket; inhibition site
224308003528	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308003529	catalytic residue [active]
224308003530	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
224308003531	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
224308003532	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
224308003533	catalytic site [active]
224308003534	subunit interface [polypeptide binding]; other site
224308003535	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815
224308003536	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224308003537	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
224308003538	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
224308003539	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224308003540	ATP-grasp domain; Region: ATP-grasp_4; cl17255
224308003541	ornithine carbamoyltransferase; Provisional; Region: PRK00779
224308003542	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
224308003543	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
224308003544	YjzC-like protein; Region: YjzC; pfam14168
224308003545	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
224308003546	UDP-apiose/xylose synthase; Region: PLN02427
224308003547	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
224308003548	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
224308003549	putative ligand binding site [chemical binding]; other site
224308003550	ComZ; Region: ComZ; pfam10815
224308003551	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
224308003552	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
224308003553	dimer interface [polypeptide binding]; other site
224308003554	active site
224308003555	CoA binding pocket [chemical binding]; other site
224308003556	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
224308003557	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
224308003558	dimer interface [polypeptide binding]; other site
224308003559	active site
224308003560	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
224308003561	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
224308003562	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
224308003563	Walker A/P-loop; other site
224308003564	ATP binding site [chemical binding]; other site
224308003565	Q-loop/lid; other site
224308003566	ABC transporter signature motif; other site
224308003567	Walker B; other site
224308003568	D-loop; other site
224308003569	H-loop/switch region; other site
224308003570	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
224308003571	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
224308003572	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
224308003573	Walker A/P-loop; other site
224308003574	ATP binding site [chemical binding]; other site
224308003575	Q-loop/lid; other site
224308003576	ABC transporter signature motif; other site
224308003577	Walker B; other site
224308003578	D-loop; other site
224308003579	H-loop/switch region; other site
224308003580	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
224308003581	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId: 15588833; Product type prc : receptor
224308003582	Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; PubMedId: 15588833, 7997159; Product type lp : lipoprotein
224308003583	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
224308003584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308003585	dimer interface [polypeptide binding]; other site
224308003586	conserved gate region; other site
224308003587	putative PBP binding loops; other site
224308003588	ABC-ATPase subunit interface; other site
224308003589	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
224308003590	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
224308003591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308003592	dimer interface [polypeptide binding]; other site
224308003593	conserved gate region; other site
224308003594	putative PBP binding loops; other site
224308003595	ABC-ATPase subunit interface; other site
224308003596	Protein of unknown function (DUF3603); Region: DUF3603; pfam12227
224308003597	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
224308003598	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
224308003599	active site
224308003600	HIGH motif; other site
224308003601	dimer interface [polypeptide binding]; other site
224308003602	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224308003603	KMSKS motif; other site
224308003604	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
224308003605	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
224308003606	peptide binding site [polypeptide binding]; other site
224308003607	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
224308003608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308003609	dimer interface [polypeptide binding]; other site
224308003610	conserved gate region; other site
224308003611	putative PBP binding loops; other site
224308003612	ABC-ATPase subunit interface; other site
224308003613	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
224308003614	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
224308003615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308003616	dimer interface [polypeptide binding]; other site
224308003617	conserved gate region; other site
224308003618	putative PBP binding loops; other site
224308003619	ABC-ATPase subunit interface; other site
224308003620	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
224308003621	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
224308003622	Walker A/P-loop; other site
224308003623	ATP binding site [chemical binding]; other site
224308003624	Q-loop/lid; other site
224308003625	ABC transporter signature motif; other site
224308003626	Walker B; other site
224308003627	D-loop; other site
224308003628	H-loop/switch region; other site
224308003629	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224308003630	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
224308003631	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
224308003632	Walker A/P-loop; other site
224308003633	ATP binding site [chemical binding]; other site
224308003634	Q-loop/lid; other site
224308003635	ABC transporter signature motif; other site
224308003636	Walker B; other site
224308003637	D-loop; other site
224308003638	H-loop/switch region; other site
224308003639	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
224308003640	H+ Antiporter protein; Region: 2A0121; TIGR00900
224308003641	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
224308003642	ArsC family; Region: ArsC; pfam03960
224308003643	putative catalytic residues [active]
224308003644	thiol/disulfide switch; other site
224308003645	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
224308003646	Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862
224308003647	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
224308003648	oligoendopeptidase F; Region: pepF; TIGR00181
224308003649	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
224308003650	active site
224308003651	Zn binding site [ion binding]; other site
224308003652	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
224308003653	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
224308003654	catalytic residues [active]
224308003655	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
224308003656	apolar tunnel; other site
224308003657	heme binding site [chemical binding]; other site
224308003658	dimerization interface [polypeptide binding]; other site
224308003659	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
224308003660	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224308003661	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224308003662	catalytic residue [active]
224308003663	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
224308003664	putative active site [active]
224308003665	putative metal binding residues [ion binding]; other site
224308003666	signature motif; other site
224308003667	putative triphosphate binding site [ion binding]; other site
224308003668	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
224308003669	synthetase active site [active]
224308003670	NTP binding site [chemical binding]; other site
224308003671	metal binding site [ion binding]; metal-binding site
224308003672	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
224308003673	ATP-NAD kinase; Region: NAD_kinase; pfam01513
224308003674	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
224308003675	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
224308003676	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
224308003677	active site
224308003678	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
224308003679	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
224308003680	active site
224308003681	metal binding site [ion binding]; metal-binding site
224308003682	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
224308003683	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
224308003684	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
224308003685	TrkA-N domain; Region: TrkA_N; pfam02254
224308003686	TrkA-C domain; Region: TrkA_C; pfam02080
224308003687	thiaminase II; Region: salvage_TenA; TIGR04306
224308003688	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
224308003689	thiamine phosphate binding site [chemical binding]; other site
224308003690	active site
224308003691	pyrophosphate binding site [ion binding]; other site
224308003692	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
224308003693	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
224308003694	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
224308003695	thiS-thiF/thiG interaction site; other site
224308003696	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
224308003697	ThiS interaction site; other site
224308003698	putative active site [active]
224308003699	tetramer interface [polypeptide binding]; other site
224308003700	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
224308003701	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
224308003702	ATP binding site [chemical binding]; other site
224308003703	substrate interface [chemical binding]; other site
224308003704	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
224308003705	dimer interface [polypeptide binding]; other site
224308003706	substrate binding site [chemical binding]; other site
224308003707	ATP binding site [chemical binding]; other site
224308003708	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
224308003709	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
224308003710	NAD binding site [chemical binding]; other site
224308003711	homotetramer interface [polypeptide binding]; other site
224308003712	homodimer interface [polypeptide binding]; other site
224308003713	substrate binding site [chemical binding]; other site
224308003714	active site
224308003715	Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153
224308003716	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
224308003717	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
224308003718	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
224308003719	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
224308003720	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
224308003721	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
224308003722	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
224308003723	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
224308003724	Part of AAA domain; Region: AAA_19; pfam13245
224308003725	Family description; Region: UvrD_C_2; pfam13538
224308003726	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308003727	Coenzyme A binding pocket [chemical binding]; other site
224308003728	hypothetical protein; Provisional; Region: PRK13679
224308003729	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
224308003730	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
224308003731	Putative esterase; Region: Esterase; pfam00756
224308003732	cystathionine gamma-synthase; Reviewed; Region: PRK08247
224308003733	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
224308003734	homodimer interface [polypeptide binding]; other site
224308003735	substrate-cofactor binding pocket; other site
224308003736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308003737	catalytic residue [active]
224308003738	cystathionine beta-lyase; Provisional; Region: PRK08064
224308003739	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
224308003740	homodimer interface [polypeptide binding]; other site
224308003741	substrate-cofactor binding pocket; other site
224308003742	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308003743	catalytic residue [active]
224308003744	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224308003745	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
224308003746	Predicted integral membrane protein [Function unknown]; Region: COG5505
224308003747	Putative amidase domain; Region: Amidase_6; pfam12671
224308003748	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
224308003749	YjcQ protein; Region: YjcQ; pfam09639
224308003750	Uncharacterized conserved protein [Function unknown]; Region: COG5484
224308003751	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
224308003752	Uncharacterized conserved protein [Function unknown]; Region: COG1359
224308003753	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
224308003754	classical (c) SDRs; Region: SDR_c; cd05233
224308003755	NAD(P) binding site [chemical binding]; other site
224308003756	active site
224308003757	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
224308003758	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
224308003759	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
224308003760	HTH domain; Region: HTH_11; pfam08279
224308003761	PRD domain; Region: PRD; pfam00874
224308003762	PRD domain; Region: PRD; pfam00874
224308003763	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
224308003764	active site
224308003765	P-loop; other site
224308003766	phosphorylation site [posttranslational modification]
224308003767	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
224308003768	active site
224308003769	phosphorylation site [posttranslational modification]
224308003770	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
224308003771	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
224308003772	active site
224308003773	P-loop; other site
224308003774	phosphorylation site [posttranslational modification]
224308003775	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
224308003776	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
224308003777	active site
224308003778	phosphorylation site [posttranslational modification]
224308003779	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
224308003780	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
224308003781	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
224308003782	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224308003783	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
224308003784	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
224308003785	putative deacylase active site [active]
224308003786	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
224308003787	Domain of unknown function (DUF4306); Region: DUF4306; pfam14154
224308003788	Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109
224308003789	UbiA prenyltransferase family; Region: UbiA; pfam01040
224308003790	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
224308003791	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
224308003792	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
224308003793	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
224308003794	NodB motif; other site
224308003795	active site
224308003796	catalytic site [active]
224308003797	Zn binding site [ion binding]; other site
224308003798	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
224308003799	Putative motility protein; Region: YjfB_motility; pfam14070
224308003800	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
224308003801	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
224308003802	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
224308003803	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
224308003804	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
224308003805	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
224308003806	4Fe-4S binding domain; Region: Fer4_6; pfam12837
224308003807	4Fe-4S binding domain; Region: Fer4; pfam00037
224308003808	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
224308003809	[4Fe-4S] binding site [ion binding]; other site
224308003810	molybdopterin cofactor binding site; other site
224308003811	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
224308003812	molybdopterin cofactor binding site; other site
224308003813	Uncharacterized conserved protein [Function unknown]; Region: COG2427
224308003814	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
224308003815	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
224308003816	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
224308003817	nudix motif; other site
224308003818	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
224308003819	Cytochrome P450; Region: p450; cl12078
224308003820	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
224308003821	glycosyltransferase, MGT family; Region: MGT; TIGR01426
224308003822	active site
224308003823	TDP-binding site; other site
224308003824	acceptor substrate-binding pocket; other site
224308003825	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
224308003826	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
224308003827	active site
224308003828	TIGR00245 family protein; Region: TIGR00245
224308003829	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
224308003830	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
224308003831	Walker A/P-loop; other site
224308003832	ATP binding site [chemical binding]; other site
224308003833	Q-loop/lid; other site
224308003834	ABC transporter signature motif; other site
224308003835	Walker B; other site
224308003836	D-loop; other site
224308003837	H-loop/switch region; other site
224308003838	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
224308003839	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
224308003840	Uncharacterized conserved protein [Function unknown]; Region: COG2427
224308003841	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
224308003842	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308003843	Glucuronate isomerase; Region: UxaC; pfam02614
224308003844	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
224308003845	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
224308003846	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308003847	putative substrate translocation pore; other site
224308003848	Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615
224308003849	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
224308003850	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
224308003851	putative NAD(P) binding site [chemical binding]; other site
224308003852	catalytic Zn binding site [ion binding]; other site
224308003853	structural Zn binding site [ion binding]; other site
224308003854	mannonate dehydratase; Provisional; Region: PRK03906
224308003855	mannonate dehydratase; Region: uxuA; TIGR00695
224308003856	D-mannonate oxidoreductase; Provisional; Region: PRK08277
224308003857	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
224308003858	putative NAD(P) binding site [chemical binding]; other site
224308003859	active site
224308003860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308003861	D-galactonate transporter; Region: 2A0114; TIGR00893
224308003862	putative substrate translocation pore; other site
224308003863	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308003864	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308003865	DNA binding site [nucleotide binding]
224308003866	domain linker motif; other site
224308003867	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
224308003868	dimerization interface [polypeptide binding]; other site
224308003869	ligand binding site [chemical binding]; other site
224308003870	altronate oxidoreductase; Provisional; Region: PRK03643
224308003871	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
224308003872	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
224308003873	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
224308003874	galactarate dehydratase; Region: galactar-dH20; TIGR03248
224308003875	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
224308003876	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
224308003877	DinB family; Region: DinB; pfam05163
224308003878	DinB superfamily; Region: DinB_2; pfam12867
224308003879	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308003880	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
224308003881	Walker A motif; other site
224308003882	ATP binding site [chemical binding]; other site
224308003883	Walker B motif; other site
224308003884	arginine finger; other site
224308003885	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308003886	binding surface
224308003887	TPR motif; other site
224308003888	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308003889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308003890	binding surface
224308003891	TPR motif; other site
224308003892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
224308003893	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
224308003894	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
224308003895	amidase catalytic site [active]
224308003896	Zn binding residues [ion binding]; other site
224308003897	substrate binding site [chemical binding]; other site
224308003898	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
224308003899	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308003900	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
224308003901	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308003902	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
224308003903	pentamer interface [polypeptide binding]; other site
224308003904	dodecaamer interface [polypeptide binding]; other site
224308003905	Phage-related replication protein [General function prediction only]; Region: COG4195
224308003906	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
224308003907	dimanganese center [ion binding]; other site
224308003908	Domain of unknown function (DUF955); Region: DUF955; pfam06114
224308003909	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308003910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308003911	non-specific DNA binding site [nucleotide binding]; other site
224308003912	salt bridge; other site
224308003913	sequence-specific DNA binding site [nucleotide binding]; other site
224308003914	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
224308003915	putative Zn2+ binding site [ion binding]; other site
224308003916	putative DNA binding site [nucleotide binding]; other site
224308003917	hypothetical protein; Provisional; Region: PRK06921
224308003918	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308003919	Walker A motif; other site
224308003920	ATP binding site [chemical binding]; other site
224308003921	Walker B motif; other site
224308003922	positive control sigma-like factor; Validated; Region: PRK06930
224308003923	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308003924	DNA binding residues [nucleotide binding]
224308003925	Phage terminase small subunit; Region: Phage_terminase; pfam10668
224308003926	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
224308003927	Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783
224308003928	Terminase-like family; Region: Terminase_6; pfam03237
224308003929	Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518
224308003930	Phage capsid family; Region: Phage_capsid; pfam05065
224308003931	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
224308003932	Domain of unknown function (DUF3599); Region: DUF3599; pfam12206
224308003933	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
224308003934	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
224308003935	Phage XkdN-like protein; Region: XkdN; pfam08890
224308003936	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
224308003937	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224308003938	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224308003939	catalytic residue [active]
224308003940	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
224308003941	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308003942	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
224308003943	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
224308003944	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
224308003945	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
224308003946	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
224308003947	XkdW protein; Region: XkdW; pfam09636
224308003948	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
224308003949	Haemolysin XhlA; Region: XhlA; pfam10779
224308003950	holin, SPP1 family; Region: holin_SPP1; TIGR01592
224308003951	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
224308003952	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
224308003953	amidase catalytic site [active]
224308003954	Zn binding residues [ion binding]; other site
224308003955	substrate binding site [chemical binding]; other site
224308003956	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308003957	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
224308003958	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308003959	Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185
224308003960	Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171
224308003961	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
224308003962	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
224308003963	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
224308003964	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
224308003965	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308003966	Zn binding site [ion binding]; other site
224308003967	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
224308003968	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308003969	Zn binding site [ion binding]; other site
224308003970	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
224308003971	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
224308003972	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
224308003973	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
224308003974	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
224308003975	Ligand binding site; other site
224308003976	Putative Catalytic site; other site
224308003977	DXD motif; other site
224308003978	Trypsin; Region: Trypsin; pfam00089
224308003979	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224308003980	protein binding site [polypeptide binding]; other site
224308003981	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
224308003982	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
224308003983	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281
224308003984	SxDxEG motif; other site
224308003985	active site
224308003986	metal binding site [ion binding]; metal-binding site
224308003987	homopentamer interface [polypeptide binding]; other site
224308003988	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
224308003989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308003990	dimer interface [polypeptide binding]; other site
224308003991	conserved gate region; other site
224308003992	putative PBP binding loops; other site
224308003993	ABC-ATPase subunit interface; other site
224308003994	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
224308003995	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
224308003996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308003997	dimer interface [polypeptide binding]; other site
224308003998	conserved gate region; other site
224308003999	putative PBP binding loops; other site
224308004000	ABC-ATPase subunit interface; other site
224308004001	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
224308004002	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
224308004003	Walker A/P-loop; other site
224308004004	ATP binding site [chemical binding]; other site
224308004005	Q-loop/lid; other site
224308004006	ABC transporter signature motif; other site
224308004007	Walker B; other site
224308004008	D-loop; other site
224308004009	H-loop/switch region; other site
224308004010	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224308004011	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
224308004012	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
224308004013	peptide binding site [polypeptide binding]; other site
224308004014	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
224308004015	dimer interface [polypeptide binding]; other site
224308004016	catalytic triad [active]
224308004017	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
224308004018	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
224308004019	active site
224308004020	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
224308004021	NlpC/P60 family; Region: NLPC_P60; pfam00877
224308004022	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
224308004023	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
224308004024	Walker A/P-loop; other site
224308004025	ATP binding site [chemical binding]; other site
224308004026	Q-loop/lid; other site
224308004027	ABC transporter signature motif; other site
224308004028	Walker B; other site
224308004029	D-loop; other site
224308004030	H-loop/switch region; other site
224308004031	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
224308004032	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
224308004033	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
224308004034	Amidinotransferase; Region: Amidinotransf; pfam02274
224308004035	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
224308004036	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
224308004037	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
224308004038	heme-binding site [chemical binding]; other site
224308004039	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
224308004040	FAD binding pocket [chemical binding]; other site
224308004041	FAD binding motif [chemical binding]; other site
224308004042	phosphate binding motif [ion binding]; other site
224308004043	beta-alpha-beta structure motif; other site
224308004044	NAD binding pocket [chemical binding]; other site
224308004045	Heme binding  pocket [chemical binding]; other site
224308004046	Predicted membrane protein [Function unknown]; Region: COG2323
224308004047	DinB superfamily; Region: DinB_2; pfam12867
224308004048	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
224308004049	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
224308004050	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
224308004051	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
224308004052	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
224308004053	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
224308004054	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
224308004055	putative active site [active]
224308004056	putative substrate binding site [chemical binding]; other site
224308004057	putative cosubstrate binding site; other site
224308004058	catalytic site [active]
224308004059	glutamate 5-kinase; Region: proB; TIGR01027
224308004060	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
224308004061	nucleotide binding site [chemical binding]; other site
224308004062	homotetrameric interface [polypeptide binding]; other site
224308004063	putative phosphate binding site [ion binding]; other site
224308004064	putative allosteric binding site; other site
224308004065	PUA domain; Region: PUA; pfam01472
224308004066	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
224308004067	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
224308004068	putative catalytic cysteine [active]
224308004069	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
224308004070	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308004071	MarR family; Region: MarR; pfam01047
224308004072	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
224308004073	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
224308004074	nucleoside/Zn binding site; other site
224308004075	dimer interface [polypeptide binding]; other site
224308004076	catalytic motif [active]
224308004077	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
224308004078	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
224308004079	THF binding site; other site
224308004080	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
224308004081	substrate binding site [chemical binding]; other site
224308004082	THF binding site; other site
224308004083	zinc-binding site [ion binding]; other site
224308004084	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
224308004085	active site
224308004086	catalytic residues [active]
224308004087	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
224308004088	Cobalt transport protein; Region: CbiQ; pfam02361
224308004089	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
224308004090	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
224308004091	Walker A/P-loop; other site
224308004092	ATP binding site [chemical binding]; other site
224308004093	Q-loop/lid; other site
224308004094	ABC transporter signature motif; other site
224308004095	Walker B; other site
224308004096	D-loop; other site
224308004097	H-loop/switch region; other site
224308004098	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
224308004099	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
224308004100	Walker A/P-loop; other site
224308004101	ATP binding site [chemical binding]; other site
224308004102	Q-loop/lid; other site
224308004103	ABC transporter signature motif; other site
224308004104	Walker B; other site
224308004105	D-loop; other site
224308004106	H-loop/switch region; other site
224308004107	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
224308004108	YKOF-related Family; Region: Ykof; pfam07615
224308004109	YKOF-related Family; Region: Ykof; pfam07615
224308004110	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308004111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308004112	active site
224308004113	phosphorylation site [posttranslational modification]
224308004114	intermolecular recognition site; other site
224308004115	dimerization interface [polypeptide binding]; other site
224308004116	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308004117	DNA binding site [nucleotide binding]
224308004118	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308004119	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308004120	dimerization interface [polypeptide binding]; other site
224308004121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308004122	dimer interface [polypeptide binding]; other site
224308004123	phosphorylation site [posttranslational modification]
224308004124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308004125	ATP binding site [chemical binding]; other site
224308004126	Mg2+ binding site [ion binding]; other site
224308004127	G-X-G motif; other site
224308004128	Predicted membrane protein [Function unknown]; Region: COG3212
224308004129	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
224308004130	Predicted membrane protein [Function unknown]; Region: COG3212
224308004131	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
224308004132	Transcriptional regulator protein (SplA); Region: SplA; pfam11132
224308004133	Evidence 5: No homology to any previously reported sequences
224308004134	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
224308004135	MgtE intracellular N domain; Region: MgtE_N; smart00924
224308004136	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
224308004137	Divalent cation transporter; Region: MgtE; pfam01769
224308004138	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
224308004139	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224308004140	DNA binding residues [nucleotide binding]
224308004141	putative dimer interface [polypeptide binding]; other site
224308004142	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308004143	MarR family; Region: MarR; pfam01047
224308004144	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
224308004145	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
224308004146	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
224308004147	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224308004148	putative active site [active]
224308004149	putative metal binding site [ion binding]; other site
224308004150	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
224308004151	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224308004152	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
224308004153	Ligand binding site; other site
224308004154	Putative Catalytic site; other site
224308004155	DXD motif; other site
224308004156	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633
224308004157	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
224308004158	active site
224308004159	DNA binding site [nucleotide binding]
224308004160	LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866
224308004161	nucleotide binding site [chemical binding]; other site
224308004162	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
224308004163	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
224308004164	putative DNA binding site [nucleotide binding]; other site
224308004165	putative homodimer interface [polypeptide binding]; other site
224308004166	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
224308004167	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
224308004168	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
224308004169	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
224308004170	PAS domain; Region: PAS_9; pfam13426
224308004171	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224308004172	metal binding site [ion binding]; metal-binding site
224308004173	active site
224308004174	I-site; other site
224308004175	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224308004176	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
224308004177	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
224308004178	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
224308004179	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
224308004180	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308004181	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
224308004182	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
224308004183	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
224308004184	heat shock protein HtpX; Provisional; Region: PRK05457
224308004185	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
224308004186	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
224308004187	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
224308004188	Acyltransferase family; Region: Acyl_transf_3; pfam01757
224308004189	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308004190	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
224308004191	putative active site [active]
224308004192	heme pocket [chemical binding]; other site
224308004193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
224308004194	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
224308004195	putative active site [active]
224308004196	heme pocket [chemical binding]; other site
224308004197	PAS domain; Region: PAS; smart00091
224308004198	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
224308004199	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308004200	putative active site [active]
224308004201	heme pocket [chemical binding]; other site
224308004202	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308004203	dimer interface [polypeptide binding]; other site
224308004204	phosphorylation site [posttranslational modification]
224308004205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308004206	ATP binding site [chemical binding]; other site
224308004207	Mg2+ binding site [ion binding]; other site
224308004208	G-X-G motif; other site
224308004209	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
224308004210	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
224308004211	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
224308004212	DNA binding site [nucleotide binding]
224308004213	active site
224308004214	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
224308004215	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
224308004216	Predicted kinase [General function prediction only]; Region: COG4857
224308004217	Phosphotransferase enzyme family; Region: APH; pfam01636
224308004218	Predicted amidohydrolase [General function prediction only]; Region: COG0388
224308004219	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
224308004220	putative active site [active]
224308004221	catalytic triad [active]
224308004222	putative dimer interface [polypeptide binding]; other site
224308004223	transaminase; Reviewed; Region: PRK08068
224308004224	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308004225	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308004226	homodimer interface [polypeptide binding]; other site
224308004227	catalytic residue [active]
224308004228	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332
224308004229	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
224308004230	dimer interface [polypeptide binding]; other site
224308004231	active site
224308004232	catalytic residue [active]
224308004233	metal binding site [ion binding]; metal-binding site
224308004234	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308004235	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
224308004236	motif II; other site
224308004237	methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754
224308004238	intersubunit interface [polypeptide binding]; other site
224308004239	active site
224308004240	Zn2+ binding site [ion binding]; other site
224308004241	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
224308004242	Cupin domain; Region: Cupin_2; pfam07883
224308004243	Uncharacterized conserved protein [Function unknown]; Region: COG3339
224308004244	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
224308004245	Cache domain; Region: Cache_1; pfam02743
224308004246	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
224308004247	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308004248	dimer interface [polypeptide binding]; other site
224308004249	phosphorylation site [posttranslational modification]
224308004250	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308004251	ATP binding site [chemical binding]; other site
224308004252	Mg2+ binding site [ion binding]; other site
224308004253	G-X-G motif; other site
224308004254	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308004255	MarR family; Region: MarR; pfam01047
224308004256	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
224308004257	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
224308004258	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224308004259	ligand binding site [chemical binding]; other site
224308004260	flagellar motor protein MotA; Validated; Region: PRK08124
224308004261	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
224308004262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308004263	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
224308004264	Walker A motif; other site
224308004265	ATP binding site [chemical binding]; other site
224308004266	Walker B motif; other site
224308004267	arginine finger; other site
224308004268	UvrB/uvrC motif; Region: UVR; pfam02151
224308004269	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308004270	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
224308004271	Walker A motif; other site
224308004272	ATP binding site [chemical binding]; other site
224308004273	Walker B motif; other site
224308004274	arginine finger; other site
224308004275	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
224308004276	Uncharacterized membrane protein [Function unknown]; Region: COG3949
224308004277	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
224308004278	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
224308004279	Ligand Binding Site [chemical binding]; other site
224308004280	6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039
224308004281	active site
224308004282	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
224308004283	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308004284	FeS/SAM binding site; other site
224308004285	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
224308004286	Predicted transcriptional regulators [Transcription]; Region: COG1733
224308004287	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
224308004288	short chain dehydrogenase; Provisional; Region: PRK06500
224308004289	classical (c) SDRs; Region: SDR_c; cd05233
224308004290	NAD(P) binding site [chemical binding]; other site
224308004291	active site
224308004292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
224308004293	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
224308004294	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
224308004295	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
224308004296	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308004297	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
224308004298	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308004299	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
224308004300	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
224308004301	active site
224308004302	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
224308004303	Protein of unknown function (DUF3219); Region: DUF3219; pfam11514
224308004304	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556
224308004305	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
224308004306	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
224308004307	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
224308004308	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
224308004309	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
224308004310	catalytic residues [active]
224308004311	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
224308004312	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224308004313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308004314	motif II; other site
224308004315	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
224308004316	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
224308004317	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
224308004318	active site
224308004319	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308004320	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308004321	DNA binding site [nucleotide binding]
224308004322	domain linker motif; other site
224308004323	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
224308004324	putative dimerization interface [polypeptide binding]; other site
224308004325	putative ligand binding site [chemical binding]; other site
224308004326	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
224308004327	CAT RNA binding domain; Region: CAT_RBD; pfam03123
224308004328	PRD domain; Region: PRD; pfam00874
224308004329	PRD domain; Region: PRD; pfam00874
224308004330	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
224308004331	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
224308004332	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224308004333	active site turn [active]
224308004334	phosphorylation site [posttranslational modification]
224308004335	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
224308004336	HPr interaction site; other site
224308004337	glycerol kinase (GK) interaction site [polypeptide binding]; other site
224308004338	active site
224308004339	phosphorylation site [posttranslational modification]
224308004340	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
224308004341	dimerization domain swap beta strand [polypeptide binding]; other site
224308004342	regulatory protein interface [polypeptide binding]; other site
224308004343	active site
224308004344	regulatory phosphorylation site [posttranslational modification]; other site
224308004345	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
224308004346	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
224308004347	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
224308004348	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
224308004349	Transcriptional regulator protein (SplA); Region: SplA; pfam11132
224308004350	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
224308004351	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308004352	FeS/SAM binding site; other site
224308004353	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308004354	Coenzyme A binding pocket [chemical binding]; other site
224308004355	Cache domain; Region: Cache_1; pfam02743
224308004356	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308004357	dimerization interface [polypeptide binding]; other site
224308004358	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
224308004359	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308004360	dimer interface [polypeptide binding]; other site
224308004361	putative CheW interface [polypeptide binding]; other site
224308004362	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
224308004363	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
224308004364	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
224308004365	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
224308004366	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
224308004367	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
224308004368	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
224308004369	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224308004370	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308004371	putative active site [active]
224308004372	heme pocket [chemical binding]; other site
224308004373	PAS fold; Region: PAS; pfam00989
224308004374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308004375	putative active site [active]
224308004376	heme pocket [chemical binding]; other site
224308004377	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
224308004378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308004379	putative active site [active]
224308004380	heme pocket [chemical binding]; other site
224308004381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308004382	dimer interface [polypeptide binding]; other site
224308004383	phosphorylation site [posttranslational modification]
224308004384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308004385	ATP binding site [chemical binding]; other site
224308004386	Mg2+ binding site [ion binding]; other site
224308004387	G-X-G motif; other site
224308004388	aminotransferase A; Validated; Region: PRK07683
224308004389	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308004390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308004391	homodimer interface [polypeptide binding]; other site
224308004392	catalytic residue [active]
224308004393	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
224308004394	putative CheA interaction surface; other site
224308004395	Response regulator receiver domain; Region: Response_reg; pfam00072
224308004396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308004397	active site
224308004398	phosphorylation site [posttranslational modification]
224308004399	intermolecular recognition site; other site
224308004400	dimerization interface [polypeptide binding]; other site
224308004401	YkyB-like protein; Region: YkyB; pfam14177
224308004402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308004403	H+ Antiporter protein; Region: 2A0121; TIGR00900
224308004404	putative substrate translocation pore; other site
224308004405	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308004406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
224308004407	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
224308004408	phosphodiesterase YaeI; Provisional; Region: PRK11340
224308004409	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
224308004410	putative active site [active]
224308004411	putative metal binding site [ion binding]; other site
224308004412	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
224308004413	short chain dehydrogenase; Provisional; Region: PRK07677
224308004414	NAD(P) binding site [chemical binding]; other site
224308004415	substrate binding site [chemical binding]; other site
224308004416	homotetramer interface [polypeptide binding]; other site
224308004417	active site
224308004418	homodimer interface [polypeptide binding]; other site
224308004419	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308004420	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
224308004421	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308004422	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
224308004423	active site
224308004424	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224308004425	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
224308004426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
224308004427	Protein of unknown function (DUF458); Region: DUF458; pfam04308
224308004428	Antirepressor AbbA; Region: AbbA_antirepres; pfam14156
224308004429	FOG: CBS domain [General function prediction only]; Region: COG0517
224308004430	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
224308004431	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308004432	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308004433	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308004434	dimerization interface [polypeptide binding]; other site
224308004435	flavodoxin; Provisional; Region: PRK06703
224308004436	BNR repeat-like domain; Region: BNR_2; pfam13088
224308004437	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
224308004438	flavodoxin, short chain; Region: flav_short; TIGR01753
224308004439	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
224308004440	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
224308004441	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
224308004442	active site
224308004443	trimer interface [polypeptide binding]; other site
224308004444	substrate binding site [chemical binding]; other site
224308004445	CoA binding site [chemical binding]; other site
224308004446	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
224308004447	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
224308004448	metal binding site [ion binding]; metal-binding site
224308004449	putative dimer interface [polypeptide binding]; other site
224308004450	hypothetical protein; Provisional; Region: PRK03094
224308004451	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
224308004452	Mechanosensitive ion channel; Region: MS_channel; pfam00924
224308004453	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
224308004454	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
224308004455	dimer interface [polypeptide binding]; other site
224308004456	decamer (pentamer of dimers) interface [polypeptide binding]; other site
224308004457	catalytic triad [active]
224308004458	peroxidatic and resolving cysteines [active]
224308004459	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
224308004460	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
224308004461	catalytic residues [active]
224308004462	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
224308004463	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
224308004464	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
224308004465	GTP binding site; other site
224308004466	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
224308004467	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
224308004468	ATP binding site [chemical binding]; other site
224308004469	substrate interface [chemical binding]; other site
224308004470	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
224308004471	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
224308004472	dimer interface [polypeptide binding]; other site
224308004473	putative functional site; other site
224308004474	putative MPT binding site; other site
224308004475	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
224308004476	Walker A motif; other site
224308004477	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
224308004478	MoaE homodimer interface [polypeptide binding]; other site
224308004479	MoaD interaction [polypeptide binding]; other site
224308004480	active site residues [active]
224308004481	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
224308004482	MoaE interaction surface [polypeptide binding]; other site
224308004483	MoeB interaction surface [polypeptide binding]; other site
224308004484	thiocarboxylated glycine; other site
224308004485	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224308004486	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308004487	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
224308004488	Walker A/P-loop; other site
224308004489	ATP binding site [chemical binding]; other site
224308004490	Q-loop/lid; other site
224308004491	ABC transporter signature motif; other site
224308004492	Walker B; other site
224308004493	D-loop; other site
224308004494	H-loop/switch region; other site
224308004495	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224308004496	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308004497	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
224308004498	Walker A/P-loop; other site
224308004499	ATP binding site [chemical binding]; other site
224308004500	Q-loop/lid; other site
224308004501	ABC transporter signature motif; other site
224308004502	Walker B; other site
224308004503	D-loop; other site
224308004504	H-loop/switch region; other site
224308004505	Yip1 domain; Region: Yip1; pfam04893
224308004506	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
224308004507	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
224308004508	HlyD family secretion protein; Region: HlyD_3; pfam13437
224308004509	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224308004510	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
224308004511	Walker A/P-loop; other site
224308004512	ATP binding site [chemical binding]; other site
224308004513	Q-loop/lid; other site
224308004514	ABC transporter signature motif; other site
224308004515	Walker B; other site
224308004516	D-loop; other site
224308004517	H-loop/switch region; other site
224308004518	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
224308004519	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
224308004520	FtsX-like permease family; Region: FtsX; pfam02687
224308004521	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224308004522	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
224308004523	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
224308004524	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
224308004525	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
224308004526	putative substrate binding site [chemical binding]; other site
224308004527	putative ATP binding site [chemical binding]; other site
224308004528	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
224308004529	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
224308004530	active site
224308004531	phosphorylation site [posttranslational modification]
224308004532	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
224308004533	active site
224308004534	P-loop; other site
224308004535	phosphorylation site [posttranslational modification]
224308004536	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
224308004537	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
224308004538	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224308004539	Catalytic site [active]
224308004540	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
224308004541	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308004542	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308004543	ABC transporter; Region: ABC_tran_2; pfam12848
224308004544	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
224308004545	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
224308004546	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
224308004547	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
224308004548	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
224308004549	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
224308004550	rod-share determining protein MreBH; Provisional; Region: PRK13929
224308004551	MreB and similar proteins; Region: MreB_like; cd10225
224308004552	nucleotide binding site [chemical binding]; other site
224308004553	Mg binding site [ion binding]; other site
224308004554	putative protofilament interaction site [polypeptide binding]; other site
224308004555	RodZ interaction site [polypeptide binding]; other site
224308004556	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
224308004557	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
224308004558	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
224308004559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308004560	putative active site [active]
224308004561	heme pocket [chemical binding]; other site
224308004562	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308004563	dimer interface [polypeptide binding]; other site
224308004564	phosphorylation site [posttranslational modification]
224308004565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308004566	ATP binding site [chemical binding]; other site
224308004567	Mg2+ binding site [ion binding]; other site
224308004568	G-X-G motif; other site
224308004569	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
224308004570	putative active site pocket [active]
224308004571	dimerization interface [polypeptide binding]; other site
224308004572	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
224308004573	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
224308004574	putative active site pocket [active]
224308004575	dimerization interface [polypeptide binding]; other site
224308004576	putative catalytic residue [active]
224308004577	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
224308004578	TrkA-N domain; Region: TrkA_N; pfam02254
224308004579	TrkA-C domain; Region: TrkA_C; pfam02080
224308004580	adenine deaminase; Region: ade; TIGR01178
224308004581	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224308004582	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
224308004583	active site
224308004584	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
224308004585	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
224308004586	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
224308004587	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
224308004588	hypothetical protein; Provisional; Region: PRK13667
224308004589	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
224308004590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308004591	active site
224308004592	motif I; other site
224308004593	motif II; other site
224308004594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308004595	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
224308004596	active site
224308004597	catalytic residues [active]
224308004598	metal binding site [ion binding]; metal-binding site
224308004599	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
224308004600	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
224308004601	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
224308004602	TPP-binding site [chemical binding]; other site
224308004603	tetramer interface [polypeptide binding]; other site
224308004604	heterodimer interface [polypeptide binding]; other site
224308004605	phosphorylation loop region [posttranslational modification]
224308004606	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
224308004607	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
224308004608	alpha subunit interface [polypeptide binding]; other site
224308004609	TPP binding site [chemical binding]; other site
224308004610	heterodimer interface [polypeptide binding]; other site
224308004611	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224308004612	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
224308004613	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224308004614	E3 interaction surface; other site
224308004615	lipoyl attachment site [posttranslational modification]; other site
224308004616	e3 binding domain; Region: E3_binding; pfam02817
224308004617	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
224308004618	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
224308004619	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
224308004620	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308004621	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
224308004622	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
224308004623	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
224308004624	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
224308004625	homodimer interface [polypeptide binding]; other site
224308004626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308004627	catalytic residue [active]
224308004628	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
224308004629	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
224308004630	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
224308004631	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
224308004632	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
224308004633	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
224308004634	active site
224308004635	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
224308004636	Coenzyme A binding pocket [chemical binding]; other site
224308004637	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
224308004638	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
224308004639	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
224308004640	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
224308004641	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
224308004642	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
224308004643	active site
224308004644	Zn binding site [ion binding]; other site
224308004645	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308004646	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
224308004647	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308004648	DNA binding residues [nucleotide binding]
224308004649	Predicted integral membrane protein [Function unknown]; Region: COG5660
224308004650	Putative zinc-finger; Region: zf-HC2; pfam13490
224308004651	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
224308004652	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
224308004653	G1 box; other site
224308004654	putative GEF interaction site [polypeptide binding]; other site
224308004655	GTP/Mg2+ binding site [chemical binding]; other site
224308004656	Switch I region; other site
224308004657	G2 box; other site
224308004658	G3 box; other site
224308004659	Switch II region; other site
224308004660	G4 box; other site
224308004661	G5 box; other site
224308004662	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
224308004663	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
224308004664	YlaH-like protein; Region: YlaH; pfam14036
224308004665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
224308004666	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
224308004667	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
224308004668	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
224308004669	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
224308004670	putative active site [active]
224308004671	PhoH-like protein; Region: PhoH; pfam02562
224308004672	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
224308004673	glutaminase A; Region: Gln_ase; TIGR03814
224308004674	hypothetical protein; Provisional; Region: PRK13666
224308004675	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
224308004676	pyruvate carboxylase; Reviewed; Region: PRK12999
224308004677	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224308004678	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
224308004679	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
224308004680	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
224308004681	active site
224308004682	catalytic residues [active]
224308004683	metal binding site [ion binding]; metal-binding site
224308004684	homodimer binding site [polypeptide binding]; other site
224308004685	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224308004686	carboxyltransferase (CT) interaction site; other site
224308004687	biotinylation site [posttranslational modification]; other site
224308004688	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
224308004689	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
224308004690	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
224308004691	UbiA prenyltransferase family; Region: UbiA; pfam01040
224308004692	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
224308004693	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
224308004694	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
224308004695	Cytochrome c; Region: Cytochrom_C; pfam00034
224308004696	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
224308004697	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
224308004698	D-pathway; other site
224308004699	Putative ubiquinol binding site [chemical binding]; other site
224308004700	Low-spin heme (heme b) binding site [chemical binding]; other site
224308004701	Putative water exit pathway; other site
224308004702	Binuclear center (heme o3/CuB) [ion binding]; other site
224308004703	K-pathway; other site
224308004704	Putative proton exit pathway; other site
224308004705	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
224308004706	Subunit I/III interface [polypeptide binding]; other site
224308004707	Subunit III/IV interface [polypeptide binding]; other site
224308004708	cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908
224308004709	cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737
224308004710	YugN-like family; Region: YugN; pfam08868
224308004711	FOG: CBS domain [General function prediction only]; Region: COG0517
224308004712	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
224308004713	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
224308004714	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
224308004715	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
224308004716	Putative coat protein; Region: YlbD_coat; pfam14071
224308004717	YlbE-like protein; Region: YlbE; pfam14003
224308004718	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
224308004719	hypothetical protein; Provisional; Region: PRK02886
224308004720	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
224308004721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308004722	S-adenosylmethionine binding site [chemical binding]; other site
224308004723	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
224308004724	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
224308004725	active site
224308004726	(T/H)XGH motif; other site
224308004727	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
224308004728	Nucleoside recognition; Region: Gate; pfam07670
224308004729	Nucleoside recognition; Region: Gate; pfam07670
224308004730	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
224308004731	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
224308004732	nucleophile elbow; other site
224308004733	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
224308004734	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
224308004735	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
224308004736	protein binding site [polypeptide binding]; other site
224308004737	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
224308004738	hypothetical protein; Provisional; Region: PRK13670
224308004739	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
224308004740	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
224308004741	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
224308004742	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
224308004743	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
224308004744	hypothetical protein; Provisional; Region: PRK13688
224308004745	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308004746	Coenzyme A binding pocket [chemical binding]; other site
224308004747	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
224308004748	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
224308004749	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
224308004750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
224308004751	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
224308004752	mraZ protein; Region: TIGR00242
224308004753	MraZ protein; Region: MraZ; pfam02381
224308004754	MraZ protein; Region: MraZ; pfam02381
224308004755	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
224308004756	MraW methylase family; Region: Methyltransf_5; pfam01795
224308004757	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
224308004758	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
224308004759	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
224308004760	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224308004761	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
224308004762	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
224308004763	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
224308004764	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
224308004765	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224308004766	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
224308004767	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
224308004768	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224308004769	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224308004770	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224308004771	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
224308004772	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
224308004773	Mg++ binding site [ion binding]; other site
224308004774	putative catalytic motif [active]
224308004775	putative substrate binding site [chemical binding]; other site
224308004776	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
224308004777	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224308004778	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224308004779	stage V sporulation protein E; Region: spoVE; TIGR02615
224308004780	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
224308004781	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
224308004782	active site
224308004783	homodimer interface [polypeptide binding]; other site
224308004784	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
224308004785	FAD binding domain; Region: FAD_binding_4; pfam01565
224308004786	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
224308004787	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
224308004788	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
224308004789	Cell division protein FtsQ; Region: FtsQ; pfam03799
224308004790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
224308004791	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
224308004792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
224308004793	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
224308004794	Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856
224308004795	cell division protein FtsA; Region: ftsA; TIGR01174
224308004796	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224308004797	nucleotide binding site [chemical binding]; other site
224308004798	Cell division protein FtsA; Region: FtsA; pfam14450
224308004799	cell division protein FtsZ; Validated; Region: PRK09330
224308004800	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
224308004801	nucleotide binding site [chemical binding]; other site
224308004802	SulA interaction site; other site
224308004803	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
224308004804	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
224308004805	Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481
224308004806	active site
224308004807	catalytic triad [active]
224308004808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
224308004809	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
224308004810	Cna protein B-type domain; Region: Cna_B_2; pfam13715
224308004811	Cna protein B-type domain; Region: Cna_B_2; pfam13715
224308004812	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
224308004813	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
224308004814	sporulation sigma factor SigE; Reviewed; Region: PRK08301
224308004815	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308004816	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308004817	DNA binding residues [nucleotide binding]
224308004818	sporulation sigma factor SigG; Reviewed; Region: PRK08215
224308004819	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308004820	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224308004821	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308004822	DNA binding residues [nucleotide binding]
224308004823	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
224308004824	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
224308004825	Walker A/P-loop; other site
224308004826	ATP binding site [chemical binding]; other site
224308004827	Q-loop/lid; other site
224308004828	ABC transporter signature motif; other site
224308004829	Walker B; other site
224308004830	D-loop; other site
224308004831	H-loop/switch region; other site
224308004832	acetylornithine deacetylase; Validated; Region: PRK08596
224308004833	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
224308004834	metal binding site [ion binding]; metal-binding site
224308004835	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
224308004836	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
224308004837	uncharacterized protein, YfiH family; Region: TIGR00726
224308004838	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
224308004839	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224308004840	catalytic residue [active]
224308004841	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
224308004842	YGGT family; Region: YGGT; pfam02325
224308004843	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
224308004844	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308004845	RNA binding surface [nucleotide binding]; other site
224308004846	DivIVA protein; Region: DivIVA; pfam05103
224308004847	DivIVA domain; Region: DivI1A_domain; TIGR03544
224308004848	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
224308004849	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
224308004850	HIGH motif; other site
224308004851	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
224308004852	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
224308004853	active site
224308004854	KMSKS motif; other site
224308004855	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
224308004856	tRNA binding surface [nucleotide binding]; other site
224308004857	anticodon binding site; other site
224308004858	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
224308004859	lipoprotein signal peptidase; Region: lspA; TIGR00077
224308004860	lipoprotein signal peptidase; Provisional; Region: PRK14787
224308004861	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
224308004862	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308004863	RNA binding surface [nucleotide binding]; other site
224308004864	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
224308004865	active site
224308004866	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
224308004867	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308004868	active site
224308004869	uracil-xanthine permease; Region: ncs2; TIGR00801
224308004870	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
224308004871	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
224308004872	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
224308004873	dihydroorotase; Validated; Region: pyrC; PRK09357
224308004874	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
224308004875	active site
224308004876	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
224308004877	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
224308004878	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
224308004879	catalytic site [active]
224308004880	subunit interface [polypeptide binding]; other site
224308004881	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
224308004882	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224308004883	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
224308004884	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
224308004885	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224308004886	ATP-grasp domain; Region: ATP-grasp_4; cl17255
224308004887	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
224308004888	IMP binding site; other site
224308004889	dimer interface [polypeptide binding]; other site
224308004890	interdomain contacts; other site
224308004891	partial ornithine binding site; other site
224308004892	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
224308004893	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
224308004894	FAD binding pocket [chemical binding]; other site
224308004895	FAD binding motif [chemical binding]; other site
224308004896	phosphate binding motif [ion binding]; other site
224308004897	beta-alpha-beta structure motif; other site
224308004898	NAD binding pocket [chemical binding]; other site
224308004899	Iron coordination center [ion binding]; other site
224308004900	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
224308004901	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
224308004902	heterodimer interface [polypeptide binding]; other site
224308004903	active site
224308004904	FMN binding site [chemical binding]; other site
224308004905	homodimer interface [polypeptide binding]; other site
224308004906	substrate binding site [chemical binding]; other site
224308004907	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
224308004908	active site
224308004909	dimer interface [polypeptide binding]; other site
224308004910	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308004911	active site
224308004912	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
224308004913	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
224308004914	Active Sites [active]
224308004915	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
224308004916	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
224308004917	ATP-sulfurylase; Region: ATPS; cd00517
224308004918	active site
224308004919	HXXH motif; other site
224308004920	flexible loop; other site
224308004921	AAA domain; Region: AAA_33; pfam13671
224308004922	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
224308004923	ligand-binding site [chemical binding]; other site
224308004924	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
224308004925	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
224308004926	active site
224308004927	SAM binding site [chemical binding]; other site
224308004928	homodimer interface [polypeptide binding]; other site
224308004929	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
224308004930	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
224308004931	putative active site [active]
224308004932	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
224308004933	putative active site [active]
224308004934	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
224308004935	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
224308004936	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
224308004937	Domain of unknown function (DUF814); Region: DUF814; pfam05670
224308004938	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
224308004939	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
224308004940	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224308004941	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
224308004942	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308004943	motif II; other site
224308004944	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
224308004945	TIGR00255 family protein; Region: TIGR00255
224308004946	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
224308004947	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
224308004948	hypothetical protein; Provisional; Region: PRK04323
224308004949	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
224308004950	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
224308004951	catalytic site [active]
224308004952	G-X2-G-X-G-K; other site
224308004953	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
224308004954	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
224308004955	Flavoprotein; Region: Flavoprotein; pfam02441
224308004956	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
224308004957	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
224308004958	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308004959	ATP binding site [chemical binding]; other site
224308004960	putative Mg++ binding site [ion binding]; other site
224308004961	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308004962	nucleotide binding region [chemical binding]; other site
224308004963	ATP-binding site [chemical binding]; other site
224308004964	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
224308004965	active site
224308004966	catalytic residues [active]
224308004967	metal binding site [ion binding]; metal-binding site
224308004968	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
224308004969	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
224308004970	putative active site [active]
224308004971	substrate binding site [chemical binding]; other site
224308004972	putative cosubstrate binding site; other site
224308004973	catalytic site [active]
224308004974	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
224308004975	substrate binding site [chemical binding]; other site
224308004976	16S rRNA methyltransferase B; Provisional; Region: PRK14902
224308004977	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
224308004978	putative RNA binding site [nucleotide binding]; other site
224308004979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308004980	S-adenosylmethionine binding site [chemical binding]; other site
224308004981	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
224308004982	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308004983	FeS/SAM binding site; other site
224308004984	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
224308004985	Protein phosphatase 2C; Region: PP2C; pfam00481
224308004986	active site
224308004987	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
224308004988	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
224308004989	active site
224308004990	ATP binding site [chemical binding]; other site
224308004991	substrate binding site [chemical binding]; other site
224308004992	activation loop (A-loop); other site
224308004993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
224308004994	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
224308004995	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
224308004996	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
224308004997	GTPase RsgA; Reviewed; Region: PRK00098
224308004998	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
224308004999	RNA binding site [nucleotide binding]; other site
224308005000	homodimer interface [polypeptide binding]; other site
224308005001	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
224308005002	GTPase/Zn-binding domain interface [polypeptide binding]; other site
224308005003	GTP/Mg2+ binding site [chemical binding]; other site
224308005004	G4 box; other site
224308005005	G5 box; other site
224308005006	G1 box; other site
224308005007	Switch I region; other site
224308005008	G2 box; other site
224308005009	G3 box; other site
224308005010	Switch II region; other site
224308005011	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
224308005012	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
224308005013	substrate binding site [chemical binding]; other site
224308005014	hexamer interface [polypeptide binding]; other site
224308005015	metal binding site [ion binding]; metal-binding site
224308005016	Thiamine pyrophosphokinase; Region: TPK; cd07995
224308005017	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
224308005018	active site
224308005019	dimerization interface [polypeptide binding]; other site
224308005020	thiamine binding site [chemical binding]; other site
224308005021	stage V sporulation protein M; Provisional; Region: spoVM; PRK14741
224308005022	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
224308005023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
224308005024	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
224308005025	DAK2 domain; Region: Dak2; pfam02734
224308005026	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
224308005027	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
224308005028	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
224308005029	putative L-serine binding site [chemical binding]; other site
224308005030	L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718
224308005031	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
224308005032	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
224308005033	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
224308005034	generic binding surface II; other site
224308005035	ssDNA binding site; other site
224308005036	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308005037	ATP binding site [chemical binding]; other site
224308005038	putative Mg++ binding site [ion binding]; other site
224308005039	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308005040	nucleotide binding region [chemical binding]; other site
224308005041	ATP-binding site [chemical binding]; other site
224308005042	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
224308005043	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
224308005044	putative phosphate acyltransferase; Provisional; Region: PRK05331
224308005045	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
224308005046	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
224308005047	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
224308005048	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
224308005049	NAD(P) binding site [chemical binding]; other site
224308005050	homotetramer interface [polypeptide binding]; other site
224308005051	homodimer interface [polypeptide binding]; other site
224308005052	active site
224308005053	acyl carrier protein; Provisional; Region: acpP; PRK00982
224308005054	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
224308005055	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
224308005056	dimerization interface [polypeptide binding]; other site
224308005057	active site
224308005058	metal binding site [ion binding]; metal-binding site
224308005059	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
224308005060	dsRNA binding site [nucleotide binding]; other site
224308005061	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
224308005062	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
224308005063	Walker A/P-loop; other site
224308005064	ATP binding site [chemical binding]; other site
224308005065	Q-loop/lid; other site
224308005066	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
224308005067	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
224308005068	ABC transporter signature motif; other site
224308005069	Walker B; other site
224308005070	D-loop; other site
224308005071	H-loop/switch region; other site
224308005072	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
224308005073	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
224308005074	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
224308005075	GTP binding site [chemical binding]; other site
224308005076	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
224308005077	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
224308005078	putative DNA-binding protein; Validated; Region: PRK00118
224308005079	signal recognition particle protein; Provisional; Region: PRK10867
224308005080	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
224308005081	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
224308005082	P loop; other site
224308005083	GTP binding site [chemical binding]; other site
224308005084	Signal peptide binding domain; Region: SRP_SPB; pfam02978
224308005085	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
224308005086	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
224308005087	KH domain; Region: KH_4; pfam13083
224308005088	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
224308005089	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
224308005090	RimM N-terminal domain; Region: RimM; pfam01782
224308005091	PRC-barrel domain; Region: PRC; pfam05239
224308005092	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
224308005093	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
224308005094	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
224308005095	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
224308005096	GTP/Mg2+ binding site [chemical binding]; other site
224308005097	G4 box; other site
224308005098	G5 box; other site
224308005099	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
224308005100	G1 box; other site
224308005101	G1 box; other site
224308005102	GTP/Mg2+ binding site [chemical binding]; other site
224308005103	Switch I region; other site
224308005104	G2 box; other site
224308005105	G2 box; other site
224308005106	G3 box; other site
224308005107	G3 box; other site
224308005108	Switch II region; other site
224308005109	Switch II region; other site
224308005110	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
224308005111	RNA/DNA hybrid binding site [nucleotide binding]; other site
224308005112	active site
224308005113	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
224308005114	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
224308005115	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
224308005116	CoA-ligase; Region: Ligase_CoA; pfam00549
224308005117	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
224308005118	CoA binding domain; Region: CoA_binding; smart00881
224308005119	CoA-ligase; Region: Ligase_CoA; pfam00549
224308005120	DNA protecting protein DprA; Region: dprA; TIGR00732
224308005121	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
224308005122	DNA topoisomerase I; Validated; Region: PRK05582
224308005123	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
224308005124	active site
224308005125	interdomain interaction site; other site
224308005126	putative metal-binding site [ion binding]; other site
224308005127	nucleotide binding site [chemical binding]; other site
224308005128	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
224308005129	domain I; other site
224308005130	DNA binding groove [nucleotide binding]
224308005131	phosphate binding site [ion binding]; other site
224308005132	domain II; other site
224308005133	domain III; other site
224308005134	nucleotide binding site [chemical binding]; other site
224308005135	catalytic site [active]
224308005136	domain IV; other site
224308005137	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
224308005138	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
224308005139	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
224308005140	Glucose inhibited division protein A; Region: GIDA; pfam01134
224308005141	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
224308005142	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
224308005143	active site
224308005144	Int/Topo IB signature motif; other site
224308005145	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
224308005146	active site
224308005147	HslU subunit interaction site [polypeptide binding]; other site
224308005148	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
224308005149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308005150	Walker A motif; other site
224308005151	ATP binding site [chemical binding]; other site
224308005152	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
224308005153	Walker B motif; other site
224308005154	arginine finger; other site
224308005155	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
224308005156	transcriptional repressor CodY; Validated; Region: PRK04158
224308005157	CodY GAF-like domain; Region: CodY; pfam06018
224308005158	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
224308005159	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
224308005160	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
224308005161	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
224308005162	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
224308005163	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
224308005164	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224308005165	flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728
224308005166	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
224308005167	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
224308005168	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
224308005169	flagellar motor switch protein FliG; Region: fliG; TIGR00207
224308005170	MgtE intracellular N domain; Region: MgtE_N; smart00924
224308005171	FliG C-terminal domain; Region: FliG_C; pfam01706
224308005172	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
224308005173	Flagellar assembly protein FliH; Region: FliH; pfam02108
224308005174	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721
224308005175	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
224308005176	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
224308005177	Walker A motif/ATP binding site; other site
224308005178	Walker B motif; other site
224308005179	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
224308005180	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
224308005181	Uncharacterized conserved protein [Function unknown]; Region: COG3334
224308005182	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
224308005183	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
224308005184	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
224308005185	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
224308005186	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
224308005187	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
224308005188	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224308005189	Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582
224308005190	Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580
224308005191	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
224308005192	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
224308005193	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
224308005194	flagellar motor switch protein; Validated; Region: PRK08119
224308005195	CheC-like family; Region: CheC; pfam04509
224308005196	CheC-like family; Region: CheC; pfam04509
224308005197	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
224308005198	Response regulator receiver domain; Region: Response_reg; pfam00072
224308005199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308005200	active site
224308005201	phosphorylation site [posttranslational modification]
224308005202	intermolecular recognition site; other site
224308005203	dimerization interface [polypeptide binding]; other site
224308005204	flagella biosynthesis protein FliZ; Provisional; Region: PRK13415
224308005205	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
224308005206	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
224308005207	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
224308005208	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
224308005209	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
224308005210	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
224308005211	FHIPEP family; Region: FHIPEP; pfam00771
224308005212	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
224308005213	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
224308005214	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
224308005215	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
224308005216	P-loop; other site
224308005217	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
224308005218	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
224308005219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308005220	active site
224308005221	phosphorylation site [posttranslational modification]
224308005222	intermolecular recognition site; other site
224308005223	dimerization interface [polypeptide binding]; other site
224308005224	CheB methylesterase; Region: CheB_methylest; pfam01339
224308005225	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
224308005226	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
224308005227	putative binding surface; other site
224308005228	active site
224308005229	P2 response regulator binding domain; Region: P2; pfam07194
224308005230	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
224308005231	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308005232	ATP binding site [chemical binding]; other site
224308005233	Mg2+ binding site [ion binding]; other site
224308005234	G-X-G motif; other site
224308005235	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
224308005236	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
224308005237	putative CheA interaction surface; other site
224308005238	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
224308005239	CheC-like family; Region: CheC; pfam04509
224308005240	CheC-like family; Region: CheC; pfam04509
224308005241	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
224308005242	RNA polymerase sigma factor SigD; Validated; Region: PRK07670
224308005243	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308005244	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224308005245	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308005246	DNA binding residues [nucleotide binding]
224308005247	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
224308005248	rRNA interaction site [nucleotide binding]; other site
224308005249	S8 interaction site; other site
224308005250	putative laminin-1 binding site; other site
224308005251	elongation factor Ts; Provisional; Region: tsf; PRK09377
224308005252	UBA/TS-N domain; Region: UBA; pfam00627
224308005253	Elongation factor TS; Region: EF_TS; pfam00889
224308005254	Elongation factor TS; Region: EF_TS; pfam00889
224308005255	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
224308005256	putative nucleotide binding site [chemical binding]; other site
224308005257	uridine monophosphate binding site [chemical binding]; other site
224308005258	homohexameric interface [polypeptide binding]; other site
224308005259	ribosome recycling factor; Reviewed; Region: frr; PRK00083
224308005260	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
224308005261	hinge region; other site
224308005262	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
224308005263	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
224308005264	catalytic residue [active]
224308005265	putative FPP diphosphate  binding site; other site
224308005266	putative FPP binding hydrophobic cleft; other site
224308005267	dimer interface [polypeptide binding]; other site
224308005268	putative IPP diphosphate binding site; other site
224308005269	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
224308005270	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
224308005271	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
224308005272	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
224308005273	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
224308005274	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
224308005275	RIP metalloprotease RseP; Region: TIGR00054
224308005276	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
224308005277	active site
224308005278	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
224308005279	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
224308005280	protein binding site [polypeptide binding]; other site
224308005281	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
224308005282	putative substrate binding region [chemical binding]; other site
224308005283	prolyl-tRNA synthetase; Provisional; Region: PRK09194
224308005284	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
224308005285	dimer interface [polypeptide binding]; other site
224308005286	motif 1; other site
224308005287	active site
224308005288	motif 2; other site
224308005289	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
224308005290	putative deacylase active site [active]
224308005291	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
224308005292	active site
224308005293	motif 3; other site
224308005294	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
224308005295	anticodon binding site; other site
224308005296	DNA polymerase III PolC; Validated; Region: polC; PRK00448
224308005297	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
224308005298	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
224308005299	generic binding surface II; other site
224308005300	generic binding surface I; other site
224308005301	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
224308005302	active site
224308005303	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
224308005304	active site
224308005305	catalytic site [active]
224308005306	substrate binding site [chemical binding]; other site
224308005307	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
224308005308	ribosome maturation protein RimP; Reviewed; Region: PRK00092
224308005309	Sm and related proteins; Region: Sm_like; cl00259
224308005310	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
224308005311	putative oligomer interface [polypeptide binding]; other site
224308005312	putative RNA binding site [nucleotide binding]; other site
224308005313	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
224308005314	NusA N-terminal domain; Region: NusA_N; pfam08529
224308005315	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
224308005316	RNA binding site [nucleotide binding]; other site
224308005317	homodimer interface [polypeptide binding]; other site
224308005318	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
224308005319	G-X-X-G motif; other site
224308005320	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
224308005321	G-X-X-G motif; other site
224308005322	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
224308005323	putative RNA binding cleft [nucleotide binding]; other site
224308005324	hypothetical protein; Provisional; Region: PRK07714
224308005325	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
224308005326	translation initiation factor IF-2; Region: IF-2; TIGR00487
224308005327	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
224308005328	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
224308005329	G1 box; other site
224308005330	putative GEF interaction site [polypeptide binding]; other site
224308005331	GTP/Mg2+ binding site [chemical binding]; other site
224308005332	Switch I region; other site
224308005333	G2 box; other site
224308005334	G3 box; other site
224308005335	Switch II region; other site
224308005336	G4 box; other site
224308005337	G5 box; other site
224308005338	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
224308005339	Translation-initiation factor 2; Region: IF-2; pfam11987
224308005340	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
224308005341	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
224308005342	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
224308005343	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
224308005344	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
224308005345	RNA binding site [nucleotide binding]; other site
224308005346	active site
224308005347	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
224308005348	riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083
224308005349	active site
224308005350	Riboflavin kinase; Region: Flavokinase; smart00904
224308005351	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
224308005352	16S/18S rRNA binding site [nucleotide binding]; other site
224308005353	S13e-L30e interaction site [polypeptide binding]; other site
224308005354	25S rRNA binding site [nucleotide binding]; other site
224308005355	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
224308005356	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
224308005357	RNase E interface [polypeptide binding]; other site
224308005358	trimer interface [polypeptide binding]; other site
224308005359	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
224308005360	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
224308005361	RNase E interface [polypeptide binding]; other site
224308005362	trimer interface [polypeptide binding]; other site
224308005363	active site
224308005364	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
224308005365	putative nucleic acid binding region [nucleotide binding]; other site
224308005366	G-X-X-G motif; other site
224308005367	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
224308005368	RNA binding site [nucleotide binding]; other site
224308005369	domain interface; other site
224308005370	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
224308005371	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
224308005372	NodB motif; other site
224308005373	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224308005374	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
224308005375	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
224308005376	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
224308005377	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
224308005378	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
224308005379	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
224308005380	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
224308005381	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
224308005382	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
224308005383	aspartate kinase I; Reviewed; Region: PRK08210
224308005384	AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of  the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260
224308005385	putative catalytic residues [active]
224308005386	putative nucleotide binding site [chemical binding]; other site
224308005387	putative aspartate binding site [chemical binding]; other site
224308005388	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
224308005389	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
224308005390	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
224308005391	dihydrodipicolinate synthase; Region: dapA; TIGR00674
224308005392	dimer interface [polypeptide binding]; other site
224308005393	active site
224308005394	catalytic residue [active]
224308005395	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
224308005396	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224308005397	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
224308005398	Clp protease; Region: CLP_protease; pfam00574
224308005399	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
224308005400	active site
224308005401	YlzJ-like protein; Region: YlzJ; pfam14035
224308005402	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
224308005403	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
224308005404	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
224308005405	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
224308005406	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
224308005407	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308005408	DNA-binding site [nucleotide binding]; DNA binding site
224308005409	UTRA domain; Region: UTRA; pfam07702
224308005410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308005411	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308005412	putative substrate translocation pore; other site
224308005413	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224308005414	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
224308005415	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224308005416	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
224308005417	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
224308005418	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
224308005419	classical (c) SDRs; Region: SDR_c; cd05233
224308005420	NAD(P) binding site [chemical binding]; other site
224308005421	active site
224308005422	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
224308005423	Evidence 4: Homologs of previously reported genes of unknown function
224308005424	Evidence 4: Homologs of previously reported genes of unknown function
224308005425	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
224308005426	Helix-turn-helix domain; Region: HTH_25; pfam13413
224308005427	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
224308005428	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
224308005429	competence damage-inducible protein A; Provisional; Region: PRK00549
224308005430	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
224308005431	putative MPT binding site; other site
224308005432	competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199
224308005433	recombinase A; Provisional; Region: recA; PRK09354
224308005434	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
224308005435	hexamer interface [polypeptide binding]; other site
224308005436	Walker A motif; other site
224308005437	ATP binding site [chemical binding]; other site
224308005438	Walker B motif; other site
224308005439	Beta-lactamase; Region: Beta-lactamase; pfam00144
224308005440	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
224308005441	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
224308005442	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
224308005443	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224308005444	Zn2+ binding site [ion binding]; other site
224308005445	Mg2+ binding site [ion binding]; other site
224308005446	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
224308005447	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224308005448	putative active site [active]
224308005449	metal binding site [ion binding]; metal-binding site
224308005450	homodimer binding site [polypeptide binding]; other site
224308005451	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
224308005452	Threonine dehydrogenase; Region: TDH; cd05281
224308005453	L-threonine 3-dehydrogenase; Region: tdh; TIGR00692
224308005454	structural Zn binding site [ion binding]; other site
224308005455	catalytic Zn binding site [ion binding]; other site
224308005456	tetramer interface [polypeptide binding]; other site
224308005457	NADP binding site [chemical binding]; other site
224308005458	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
224308005459	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
224308005460	substrate-cofactor binding pocket; other site
224308005461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308005462	catalytic residue [active]
224308005463	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
224308005464	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
224308005465	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308005466	FeS/SAM binding site; other site
224308005467	TRAM domain; Region: TRAM; pfam01938
224308005468	Predicted membrane protein [Function unknown]; Region: COG4550
224308005469	Outer spore coat protein E (CotE); Region: CotE; pfam10628
224308005470	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
224308005471	MutS domain I; Region: MutS_I; pfam01624
224308005472	MutS domain II; Region: MutS_II; pfam05188
224308005473	MutS domain III; Region: MutS_III; pfam05192
224308005474	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
224308005475	Walker A/P-loop; other site
224308005476	ATP binding site [chemical binding]; other site
224308005477	Q-loop/lid; other site
224308005478	ABC transporter signature motif; other site
224308005479	Walker B; other site
224308005480	D-loop; other site
224308005481	H-loop/switch region; other site
224308005482	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
224308005483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308005484	ATP binding site [chemical binding]; other site
224308005485	Mg2+ binding site [ion binding]; other site
224308005486	G-X-G motif; other site
224308005487	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
224308005488	ATP binding site [chemical binding]; other site
224308005489	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
224308005490	Regulatory protein YrvL; Region: YrvL; pfam14184
224308005491	transcriptional regulator BetI; Validated; Region: PRK00767
224308005492	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308005493	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
224308005494	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
224308005495	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
224308005496	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
224308005497	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
224308005498	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
224308005499	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
224308005500	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
224308005501	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
224308005502	FMN binding site [chemical binding]; other site
224308005503	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
224308005504	substrate binding site [chemical binding]; other site
224308005505	putative catalytic residue [active]
224308005506	acyl carrier protein; Validated; Region: PRK07117
224308005507	polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103
224308005508	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
224308005509	dimer interface [polypeptide binding]; other site
224308005510	active site
224308005511	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
224308005512	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
224308005513	dimer interface [polypeptide binding]; other site
224308005514	active site
224308005515	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224308005516	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
224308005517	substrate binding site [chemical binding]; other site
224308005518	oxyanion hole (OAH) forming residues; other site
224308005519	trimer interface [polypeptide binding]; other site
224308005520	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
224308005521	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224308005522	substrate binding site [chemical binding]; other site
224308005523	oxyanion hole (OAH) forming residues; other site
224308005524	trimer interface [polypeptide binding]; other site
224308005525	The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906
224308005526	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
224308005527	acyl-activating enzyme (AAE) consensus motif; other site
224308005528	putative AMP binding site [chemical binding]; other site
224308005529	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005530	Condensation domain; Region: Condensation; pfam00668
224308005531	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005532	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308005533	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
224308005534	acyl-activating enzyme (AAE) consensus motif; other site
224308005535	AMP binding site [chemical binding]; other site
224308005536	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005537	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005538	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005539	active site
224308005540	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
224308005541	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
224308005542	KR domain; Region: KR; pfam08659
224308005543	putative NADP binding site [chemical binding]; other site
224308005544	active site
224308005545	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005546	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005547	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005548	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005549	active site
224308005550	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
224308005551	putative NADP binding site [chemical binding]; other site
224308005552	active site
224308005553	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005554	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005555	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
224308005556	active site
224308005557	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
224308005558	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005559	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005560	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005561	active site
224308005562	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
224308005563	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
224308005564	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
224308005565	putative NADP binding site [chemical binding]; other site
224308005566	active site
224308005567	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005568	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005569	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
224308005570	active site
224308005571	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
224308005572	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
224308005573	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005574	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005575	active site
224308005576	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224308005577	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
224308005578	putative NADP binding site [chemical binding]; other site
224308005579	active site
224308005580	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005581	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005582	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
224308005583	active site
224308005584	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
224308005585	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
224308005586	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005587	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005588	active site
224308005589	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
224308005590	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
224308005591	putative NADP binding site [chemical binding]; other site
224308005592	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
224308005593	active site
224308005594	Methyltransferase domain; Region: Methyltransf_12; pfam08242
224308005595	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005596	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005597	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005598	active site
224308005599	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224308005600	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
224308005601	putative NADP binding site [chemical binding]; other site
224308005602	active site
224308005603	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005604	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005605	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
224308005606	active site
224308005607	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005608	Condensation domain; Region: Condensation; pfam00668
224308005609	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005610	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308005611	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308005612	acyl-activating enzyme (AAE) consensus motif; other site
224308005613	AMP binding site [chemical binding]; other site
224308005614	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005615	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005616	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005617	active site
224308005618	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
224308005619	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
224308005620	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
224308005621	putative NADP binding site [chemical binding]; other site
224308005622	active site
224308005623	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
224308005624	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005625	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005626	active site
224308005627	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
224308005628	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
224308005629	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
224308005630	putative NADP binding site [chemical binding]; other site
224308005631	active site
224308005632	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
224308005633	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005634	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005635	active site
224308005636	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
224308005637	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
224308005638	putative NADP binding site [chemical binding]; other site
224308005639	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
224308005640	active site
224308005641	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224308005642	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308005643	S-adenosylmethionine binding site [chemical binding]; other site
224308005644	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
224308005645	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005646	active site
224308005647	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
224308005648	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
224308005649	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
224308005650	active site
224308005651	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
224308005652	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
224308005653	Cytochrome P450; Region: p450; cl12078
224308005654	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224308005655	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
224308005656	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
224308005657	active site
224308005658	catalytic triad [active]
224308005659	Evidence 4: Homologs of previously reported genes of unknown function
224308005660	Evidence 4: Homologs of previously reported genes of unknown function
224308005661	Phage-related replication protein [General function prediction only]; Region: COG4195
224308005662	peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563
224308005663	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
224308005664	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
224308005665	YmaF family; Region: YmaF; pfam12788
224308005666	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
224308005667	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
224308005668	bacterial Hfq-like; Region: Hfq; cd01716
224308005669	hexamer interface [polypeptide binding]; other site
224308005670	Sm1 motif; other site
224308005671	RNA binding site [nucleotide binding]; other site
224308005672	Sm2 motif; other site
224308005673	YmzC-like protein; Region: YmzC; pfam14157
224308005674	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
224308005675	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
224308005676	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
224308005677	Class I ribonucleotide reductase; Region: RNR_I; cd01679
224308005678	active site
224308005679	dimer interface [polypeptide binding]; other site
224308005680	catalytic residues [active]
224308005681	effector binding site; other site
224308005682	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
224308005683	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
224308005684	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
224308005685	dimer interface [polypeptide binding]; other site
224308005686	putative radical transfer pathway; other site
224308005687	diiron center [ion binding]; other site
224308005688	tyrosyl radical; other site
224308005689	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
224308005690	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
224308005691	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
224308005692	active site
224308005693	metal binding site [ion binding]; metal-binding site
224308005694	Sporulation related domain; Region: SPOR; pfam05036
224308005695	stage V sporulation protein K; Region: spore_V_K; TIGR02881
224308005696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308005697	Walker A motif; other site
224308005698	ATP binding site [chemical binding]; other site
224308005699	Walker B motif; other site
224308005700	arginine finger; other site
224308005701	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
224308005702	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
224308005703	HflX GTPase family; Region: HflX; cd01878
224308005704	G1 box; other site
224308005705	GTP/Mg2+ binding site [chemical binding]; other site
224308005706	Switch I region; other site
224308005707	G2 box; other site
224308005708	G3 box; other site
224308005709	Switch II region; other site
224308005710	G4 box; other site
224308005711	G5 box; other site
224308005712	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
224308005713	Aluminium resistance protein; Region: Alum_res; pfam06838
224308005714	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
224308005715	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
224308005716	DNA binding residues [nucleotide binding]
224308005717	putative dimer interface [polypeptide binding]; other site
224308005718	glutamine synthetase, type I; Region: GlnA; TIGR00653
224308005719	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
224308005720	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
224308005721	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
224308005722	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224308005723	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308005724	Coenzyme A binding pocket [chemical binding]; other site
224308005725	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
224308005726	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
224308005727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308005728	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
224308005729	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
224308005730	inhibitor binding site; inhibition site
224308005731	active site
224308005732	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
224308005733	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224308005734	nucleotide binding site [chemical binding]; other site
224308005735	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
224308005736	xylose isomerase; Provisional; Region: PRK05474
224308005737	xylose isomerase; Region: xylose_isom_A; TIGR02630
224308005738	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
224308005739	N- and C-terminal domain interface [polypeptide binding]; other site
224308005740	D-xylulose kinase; Region: XylB; TIGR01312
224308005741	active site
224308005742	MgATP binding site [chemical binding]; other site
224308005743	catalytic site [active]
224308005744	metal binding site [ion binding]; metal-binding site
224308005745	xylulose binding site [chemical binding]; other site
224308005746	homodimer interface [polypeptide binding]; other site
224308005747	Staphylococcal nuclease homologues; Region: SNc; smart00318
224308005748	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
224308005749	Catalytic site; other site
224308005750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308005751	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
224308005752	putative substrate translocation pore; other site
224308005753	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308005754	alanine racemase; Region: alr; TIGR00492
224308005755	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
224308005756	active site
224308005757	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224308005758	dimer interface [polypeptide binding]; other site
224308005759	substrate binding site [chemical binding]; other site
224308005760	catalytic residues [active]
224308005761	Protein of unknown function (DUF2691); Region: DUF2691; pfam10903
224308005762	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
224308005763	trimer interface [polypeptide binding]; other site
224308005764	active site
224308005765	Evidence 5: No homology to any previously reported sequences
224308005766	thymidylate synthase; Reviewed; Region: thyA; PRK01827
224308005767	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
224308005768	dimerization interface [polypeptide binding]; other site
224308005769	active site
224308005770	Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427
224308005771	putative binding site; other site
224308005772	putative dimer interface [polypeptide binding]; other site
224308005773	YoqO-like protein; Region: YoqO; pfam14037
224308005774	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
224308005775	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
224308005776	putative hydrophobic ligand binding site [chemical binding]; other site
224308005777	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
224308005778	Spore germination protein; Region: Spore_permease; pfam03845
224308005779	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
224308005780	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
224308005781	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
224308005782	YndJ-like protein; Region: YndJ; pfam14158
224308005783	Phage-related replication protein [General function prediction only]; Region: COG4195
224308005784	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
224308005785	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
224308005786	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
224308005787	putative active site [active]
224308005788	putative Mg binding site [ion binding]; other site
224308005789	LexA repressor; Validated; Region: PRK00215
224308005790	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308005791	putative DNA binding site [nucleotide binding]; other site
224308005792	putative Zn2+ binding site [ion binding]; other site
224308005793	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
224308005794	Catalytic site [active]
224308005795	cell division suppressor protein YneA; Provisional; Region: PRK14125
224308005796	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308005797	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
224308005798	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
224308005799	catalytic residues [active]
224308005800	catalytic nucleophile [active]
224308005801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
224308005802	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
224308005803	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
224308005804	TPP-binding site [chemical binding]; other site
224308005805	dimer interface [polypeptide binding]; other site
224308005806	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
224308005807	PYR/PP interface [polypeptide binding]; other site
224308005808	dimer interface [polypeptide binding]; other site
224308005809	TPP binding site [chemical binding]; other site
224308005810	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224308005811	Protein of unknown function (DUF2522); Region: DUF2522; pfam10747
224308005812	hypothetical protein; Provisional; Region: PRK01844
224308005813	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
224308005814	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
224308005815	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
224308005816	Response regulator receiver domain; Region: Response_reg; pfam00072
224308005817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308005818	active site
224308005819	phosphorylation site [posttranslational modification]
224308005820	intermolecular recognition site; other site
224308005821	dimerization interface [polypeptide binding]; other site
224308005822	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
224308005823	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
224308005824	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
224308005825	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
224308005826	putative dimer interface [polypeptide binding]; other site
224308005827	acid-soluble spore protein P; Provisional; Region: sspP; PRK09399
224308005828	acid-soluble spore protein O; Provisional; Region: sspO; PRK02984
224308005829	aconitate hydratase; Validated; Region: PRK09277
224308005830	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
224308005831	substrate binding site [chemical binding]; other site
224308005832	ligand binding site [chemical binding]; other site
224308005833	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
224308005834	substrate binding site [chemical binding]; other site
224308005835	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
224308005836	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
224308005837	catalytic residues [active]
224308005838	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
224308005839	acid-soluble spore protein N; Provisional; Region: sspN; PRK09398
224308005840	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
224308005841	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
224308005842	active site
224308005843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
224308005844	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
224308005845	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
224308005846	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
224308005847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308005848	ATP binding site [chemical binding]; other site
224308005849	Mg2+ binding site [ion binding]; other site
224308005850	G-X-G motif; other site
224308005851	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
224308005852	anchoring element; other site
224308005853	dimer interface [polypeptide binding]; other site
224308005854	ATP binding site [chemical binding]; other site
224308005855	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
224308005856	active site
224308005857	putative metal-binding site [ion binding]; other site
224308005858	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
224308005859	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
224308005860	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
224308005861	CAP-like domain; other site
224308005862	active site
224308005863	primary dimer interface [polypeptide binding]; other site
224308005864	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308005865	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308005866	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308005867	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224308005868	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
224308005869	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
224308005870	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
224308005871	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
224308005872	Cellulose binding domain; Region: CBM_3; pfam00942
224308005873	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
224308005874	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
224308005875	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
224308005876	substrate binding site [chemical binding]; other site
224308005877	active site
224308005878	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
224308005879	metal binding site [ion binding]; metal-binding site
224308005880	ligand binding site [chemical binding]; other site
224308005881	Predicted membrane protein [Function unknown]; Region: COG2246
224308005882	GtrA-like protein; Region: GtrA; pfam04138
224308005883	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
224308005884	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
224308005885	active site
224308005886	tetramer interface; other site
224308005887	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
224308005888	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
224308005889	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
224308005890	DHH family; Region: DHH; pfam01368
224308005891	DHHA1 domain; Region: DHHA1; pfam02272
224308005892	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
224308005893	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
224308005894	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
224308005895	enoyl-CoA hydratase; Provisional; Region: PRK07657
224308005896	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224308005897	substrate binding site [chemical binding]; other site
224308005898	oxyanion hole (OAH) forming residues; other site
224308005899	trimer interface [polypeptide binding]; other site
224308005900	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
224308005901	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
224308005902	active site
224308005903	catalytic residues [active]
224308005904	metal binding site [ion binding]; metal-binding site
224308005905	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224308005906	carboxyltransferase (CT) interaction site; other site
224308005907	biotinylation site [posttranslational modification]; other site
224308005908	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
224308005909	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224308005910	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
224308005911	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
224308005912	AMP-binding domain protein; Validated; Region: PRK08315
224308005913	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
224308005914	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
224308005915	acyl-activating enzyme (AAE) consensus motif; other site
224308005916	putative AMP binding site [chemical binding]; other site
224308005917	putative active site [active]
224308005918	putative CoA binding site [chemical binding]; other site
224308005919	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224308005920	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
224308005921	active site
224308005922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
224308005923	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
224308005924	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
224308005925	Condensation domain; Region: Condensation; pfam00668
224308005926	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005927	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
224308005928	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
224308005929	acyl-activating enzyme (AAE) consensus motif; other site
224308005930	AMP binding site [chemical binding]; other site
224308005931	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005932	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
224308005933	Condensation domain; Region: Condensation; pfam00668
224308005934	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005935	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308005936	acyl-activating enzyme (AAE) consensus motif; other site
224308005937	AMP binding site [chemical binding]; other site
224308005938	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005939	Condensation domain; Region: Condensation; pfam00668
224308005940	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005941	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308005942	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308005943	acyl-activating enzyme (AAE) consensus motif; other site
224308005944	AMP binding site [chemical binding]; other site
224308005945	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005946	Condensation domain; Region: Condensation; pfam00668
224308005947	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005948	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308005949	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308005950	acyl-activating enzyme (AAE) consensus motif; other site
224308005951	AMP binding site [chemical binding]; other site
224308005952	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005953	Condensation domain; Region: Condensation; pfam00668
224308005954	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
224308005955	Condensation domain; Region: Condensation; pfam00668
224308005956	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005957	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308005958	acyl-activating enzyme (AAE) consensus motif; other site
224308005959	AMP binding site [chemical binding]; other site
224308005960	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005961	Condensation domain; Region: Condensation; pfam00668
224308005962	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005963	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308005964	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
224308005965	acyl-activating enzyme (AAE) consensus motif; other site
224308005966	AMP binding site [chemical binding]; other site
224308005967	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005968	Condensation domain; Region: Condensation; pfam00668
224308005969	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
224308005970	Condensation domain; Region: Condensation; pfam00668
224308005971	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005972	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308005973	acyl-activating enzyme (AAE) consensus motif; other site
224308005974	AMP binding site [chemical binding]; other site
224308005975	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005976	Condensation domain; Region: Condensation; pfam00668
224308005977	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005978	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308005979	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308005980	acyl-activating enzyme (AAE) consensus motif; other site
224308005981	AMP binding site [chemical binding]; other site
224308005982	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005983	Condensation domain; Region: Condensation; pfam00668
224308005984	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005985	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
224308005986	Condensation domain; Region: Condensation; pfam00668
224308005987	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005988	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308005989	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308005990	acyl-activating enzyme (AAE) consensus motif; other site
224308005991	AMP binding site [chemical binding]; other site
224308005992	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308005993	Condensation domain; Region: Condensation; pfam00668
224308005994	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308005995	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308005996	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308005997	acyl-activating enzyme (AAE) consensus motif; other site
224308005998	AMP binding site [chemical binding]; other site
224308005999	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308006000	Condensation domain; Region: Condensation; pfam00668
224308006001	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308006002	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
224308006003	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113
224308006004	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
224308006005	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
224308006006	active site
224308006007	catalytic residues [active]
224308006008	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
224308006009	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
224308006010	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
224308006011	Int/Topo IB signature motif; other site
224308006012	Helix-turn-helix domain; Region: HTH_17; cl17695
224308006013	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
224308006014	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
224308006015	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308006016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308006017	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
224308006018	putative dimerization interface [polypeptide binding]; other site
224308006019	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
224308006020	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
224308006021	NAD(P) binding site [chemical binding]; other site
224308006022	glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317
224308006023	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
224308006024	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
224308006025	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
224308006026	active site
224308006027	dimer interface [polypeptide binding]; other site
224308006028	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
224308006029	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
224308006030	active site
224308006031	FMN binding site [chemical binding]; other site
224308006032	substrate binding site [chemical binding]; other site
224308006033	3Fe-4S cluster binding site [ion binding]; other site
224308006034	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
224308006035	domain interface; other site
224308006036	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308006037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308006038	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
224308006039	putative dimerization interface [polypeptide binding]; other site
224308006040	gamma-glutamyl kinase; Provisional; Region: PRK13402
224308006041	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
224308006042	nucleotide binding site [chemical binding]; other site
224308006043	homotetrameric interface [polypeptide binding]; other site
224308006044	putative phosphate binding site [ion binding]; other site
224308006045	putative allosteric binding site; other site
224308006046	PUA domain; Region: PUA; pfam01472
224308006047	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
224308006048	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
224308006049	Replication terminator protein; Region: RTP; pfam02334
224308006050	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
224308006051	classical (c) SDRs; Region: SDR_c; cd05233
224308006052	NAD(P) binding site [chemical binding]; other site
224308006053	active site
224308006054	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
224308006055	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224308006056	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
224308006057	polyol permease family; Region: 2A0118; TIGR00897
224308006058	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308006059	putative substrate translocation pore; other site
224308006060	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
224308006061	Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798
224308006062	putative N- and C-terminal domain interface [polypeptide binding]; other site
224308006063	putative active site [active]
224308006064	putative MgATP binding site [chemical binding]; other site
224308006065	catalytic site [active]
224308006066	metal binding site [ion binding]; metal-binding site
224308006067	carbohydrate binding site [chemical binding]; other site
224308006068	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
224308006069	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
224308006070	putative ligand binding site [chemical binding]; other site
224308006071	putative NAD binding site [chemical binding]; other site
224308006072	catalytic site [active]
224308006073	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
224308006074	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
224308006075	putative [4Fe-4S] binding site [ion binding]; other site
224308006076	putative molybdopterin cofactor binding site [chemical binding]; other site
224308006077	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
224308006078	putative molybdopterin cofactor binding site; other site
224308006079	Protein of unknown function (DUF4025); Region: DUF4025; pfam13217
224308006080	CHASE3 domain; Region: CHASE3; cl05000
224308006081	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308006082	dimerization interface [polypeptide binding]; other site
224308006083	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
224308006084	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308006085	dimer interface [polypeptide binding]; other site
224308006086	putative CheW interface [polypeptide binding]; other site
224308006087	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
224308006088	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
224308006089	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
224308006090	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
224308006091	Predicted membrane protein [Function unknown]; Region: COG3619
224308006092	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
224308006093	Amb_all domain; Region: Amb_all; smart00656
224308006094	Uncharacterized conserved protein [Function unknown]; Region: COG2135
224308006095	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
224308006096	Cupin; Region: Cupin_1; smart00835
224308006097	Cupin; Region: Cupin_1; smart00835
224308006098	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
224308006099	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308006100	Coenzyme A binding pocket [chemical binding]; other site
224308006101	YoaP-like; Region: YoaP; pfam14268
224308006102	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
224308006103	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
224308006104	VanW like protein; Region: VanW; pfam04294
224308006105	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
224308006106	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308006107	salt bridge; other site
224308006108	non-specific DNA binding site [nucleotide binding]; other site
224308006109	sequence-specific DNA binding site [nucleotide binding]; other site
224308006110	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
224308006111	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308006112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308006113	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308006114	dimerization interface [polypeptide binding]; other site
224308006115	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224308006116	EamA-like transporter family; Region: EamA; pfam00892
224308006117	EamA-like transporter family; Region: EamA; pfam00892
224308006118	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
224308006119	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
224308006120	conserved cys residue [active]
224308006121	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
224308006122	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
224308006123	Protein of unknown function (DUF3221); Region: DUF3221; pfam11518
224308006124	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin
224308006125	phosphoenolpyruvate synthase; Validated; Region: PRK06241
224308006126	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
224308006127	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
224308006128	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
224308006129	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
224308006130	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308006131	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308006132	non-specific DNA binding site [nucleotide binding]; other site
224308006133	salt bridge; other site
224308006134	sequence-specific DNA binding site [nucleotide binding]; other site
224308006135	Uncharacterized conserved protein [Function unknown]; Region: COG2135
224308006136	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
224308006137	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
224308006138	putative active site [active]
224308006139	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin
224308006140	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308006141	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308006142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308006143	TPR motif; other site
224308006144	binding surface
224308006145	Y-family of DNA polymerases; Region: PolY; cl12025
224308006146	DNA binding site [nucleotide binding]
224308006147	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
224308006148	Y-family of DNA polymerases; Region: PolY; cl12025
224308006149	active site
224308006150	YolD-like protein; Region: YolD; pfam08863
224308006151	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h: extrachromosomal origin
224308006152	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
224308006153	Uncharacterized conserved protein [Function unknown]; Region: COG5444
224308006154	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
224308006155	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
224308006156	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
224308006157	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
224308006158	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
224308006159	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
224308006160	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
224308006161	dimer interface [polypeptide binding]; other site
224308006162	putative tRNA-binding site [nucleotide binding]; other site
224308006163	Cupin domain; Region: Cupin_2; pfam07883
224308006164	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308006165	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308006166	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308006167	Coenzyme A binding pocket [chemical binding]; other site
224308006168	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308006169	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308006170	WHG domain; Region: WHG; pfam13305
224308006171	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224308006172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
224308006173	Predicted transcriptional regulator [Transcription]; Region: COG2378
224308006174	HTH domain; Region: HTH_11; pfam08279
224308006175	WYL domain; Region: WYL; pfam13280
224308006176	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308006177	dimerization interface [polypeptide binding]; other site
224308006178	putative DNA binding site [nucleotide binding]; other site
224308006179	putative Zn2+ binding site [ion binding]; other site
224308006180	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
224308006181	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224308006182	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224308006183	catalytic residue [active]
224308006184	Predicted membrane protein [Function unknown]; Region: COG2322
224308006185	Protein required for attachment to host cells; Region: Host_attach; cl02398
224308006186	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
224308006187	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
224308006188	putative dimer interface [polypeptide binding]; other site
224308006189	catalytic triad [active]
224308006190	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
224308006191	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
224308006192	putative di-iron ligands [ion binding]; other site
224308006193	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
224308006194	Histidine kinase; Region: HisKA_3; pfam07730
224308006195	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
224308006196	ATP binding site [chemical binding]; other site
224308006197	Mg2+ binding site [ion binding]; other site
224308006198	G-X-G motif; other site
224308006199	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308006200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308006201	active site
224308006202	phosphorylation site [posttranslational modification]
224308006203	intermolecular recognition site; other site
224308006204	dimerization interface [polypeptide binding]; other site
224308006205	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308006206	DNA binding residues [nucleotide binding]
224308006207	dimerization interface [polypeptide binding]; other site
224308006208	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308006209	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308006210	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
224308006211	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
224308006212	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308006213	ATP binding site [chemical binding]; other site
224308006214	putative Mg++ binding site [ion binding]; other site
224308006215	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308006216	nucleotide binding region [chemical binding]; other site
224308006217	ATP-binding site [chemical binding]; other site
224308006218	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
224308006219	Helicase and RNase D C-terminal; Region: HRDC; smart00341
224308006220	azoreductase; Provisional; Region: PRK13556
224308006221	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
224308006222	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
224308006223	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
224308006224	putative dimer interface [polypeptide binding]; other site
224308006225	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
224308006226	pentamer interface [polypeptide binding]; other site
224308006227	dodecaamer interface [polypeptide binding]; other site
224308006228	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
224308006229	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224308006230	NAD(P) binding site [chemical binding]; other site
224308006231	catalytic residues [active]
224308006232	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
224308006233	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
224308006234	Active site cavity [active]
224308006235	Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657
224308006236	catalytic acid [active]
224308006237	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
224308006238	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
224308006239	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
224308006240	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
224308006241	Na2 binding site [ion binding]; other site
224308006242	putative substrate binding site 1 [chemical binding]; other site
224308006243	Na binding site 1 [ion binding]; other site
224308006244	putative substrate binding site 2 [chemical binding]; other site
224308006245	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
224308006246	Sodium Bile acid symporter family; Region: SBF; pfam01758
224308006247	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
224308006248	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224308006249	E3 interaction surface; other site
224308006250	lipoyl attachment site [posttranslational modification]; other site
224308006251	e3 binding domain; Region: E3_binding; pfam02817
224308006252	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
224308006253	2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239
224308006254	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
224308006255	TPP-binding site [chemical binding]; other site
224308006256	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
224308006257	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
224308006258	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
224308006259	metal ion-dependent adhesion site (MIDAS); other site
224308006260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308006261	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
224308006262	Walker A motif; other site
224308006263	ATP binding site [chemical binding]; other site
224308006264	Walker B motif; other site
224308006265	arginine finger; other site
224308006266	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
224308006267	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
224308006268	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
224308006269	E-class dimer interface [polypeptide binding]; other site
224308006270	P-class dimer interface [polypeptide binding]; other site
224308006271	active site
224308006272	Cu2+ binding site [ion binding]; other site
224308006273	Zn2+ binding site [ion binding]; other site
224308006274	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308006275	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308006276	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308006277	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308006278	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
224308006279	NlpC/P60 family; Region: NLPC_P60; pfam00877
224308006280	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
224308006281	glycosyltransferase, MGT family; Region: MGT; TIGR01426
224308006282	active site
224308006283	TDP-binding site; other site
224308006284	acceptor substrate-binding pocket; other site
224308006285	Uncharacterized conserved protein [Function unknown]; Region: COG1624
224308006286	Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372
224308006287	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
224308006288	multidrug efflux protein; Reviewed; Region: PRK01766
224308006289	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
224308006290	cation binding site [ion binding]; other site
224308006291	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
224308006292	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
224308006293	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
224308006294	rarD protein; Region: rarD; TIGR00688
224308006295	EamA-like transporter family; Region: EamA; pfam00892
224308006296	GntP family permease; Region: GntP_permease; pfam02447
224308006297	fructuronate transporter; Provisional; Region: PRK10034; cl15264
224308006298	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
224308006299	Predicted transcriptional regulators [Transcription]; Region: COG1733
224308006300	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308006301	dimerization interface [polypeptide binding]; other site
224308006302	putative DNA binding site [nucleotide binding]; other site
224308006303	putative Zn2+ binding site [ion binding]; other site
224308006304	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
224308006305	dimer interface [polypeptide binding]; other site
224308006306	FMN binding site [chemical binding]; other site
224308006307	Predicted esterase [General function prediction only]; Region: COG0400
224308006308	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
224308006309	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308006310	Zn binding site [ion binding]; other site
224308006311	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
224308006312	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308006313	Zn binding site [ion binding]; other site
224308006314	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
224308006315	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
224308006316	Na binding site [ion binding]; other site
224308006317	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
224308006318	C-terminal peptidase (prc); Region: prc; TIGR00225
224308006319	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
224308006320	protein binding site [polypeptide binding]; other site
224308006321	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
224308006322	Catalytic dyad [active]
224308006323	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308006324	Methyltransferase domain; Region: Methyltransf_31; pfam13847
224308006325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308006326	S-adenosylmethionine binding site [chemical binding]; other site
224308006327	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
224308006328	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
224308006329	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
224308006330	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
224308006331	YodL-like; Region: YodL; pfam14191
224308006332	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
224308006333	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
224308006334	active site
224308006335	YozD-like protein; Region: YozD; pfam14162
224308006336	hypothetical protein; Provisional; Region: PRK13672
224308006337	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
224308006338	toxin interface [polypeptide binding]; other site
224308006339	Zn binding site [ion binding]; other site
224308006340	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
224308006341	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308006342	FeS/SAM binding site; other site
224308006343	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
224308006344	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
224308006345	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308006346	Coenzyme A binding pocket [chemical binding]; other site
224308006347	acetylornithine deacetylase; Validated; Region: PRK06915
224308006348	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
224308006349	metal binding site [ion binding]; metal-binding site
224308006350	dimer interface [polypeptide binding]; other site
224308006351	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
224308006352	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
224308006353	hypothetical protein; Provisional; Region: PRK06917
224308006354	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224308006355	inhibitor-cofactor binding pocket; inhibition site
224308006356	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308006357	catalytic residue [active]
224308006358	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308006359	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
224308006360	Coenzyme A binding pocket [chemical binding]; other site
224308006361	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224308006362	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308006363	active site
224308006364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
224308006365	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
224308006366	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
224308006367	Phytase; Region: Phytase; pfam02333
224308006368	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308006369	Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331
224308006370	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308006371	non-specific DNA binding site [nucleotide binding]; other site
224308006372	salt bridge; other site
224308006373	sequence-specific DNA binding site [nucleotide binding]; other site
224308006374	Rubrerythrin [Energy production and conversion]; Region: COG1592
224308006375	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
224308006376	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224308006377	active site
224308006378	metal binding site [ion binding]; metal-binding site
224308006379	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
224308006380	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
224308006381	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
224308006382	trimer interface [polypeptide binding]; other site
224308006383	active site
224308006384	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224308006385	catalytic residues [active]
224308006386	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
224308006387	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
224308006388	dimer interface [polypeptide binding]; other site
224308006389	putative radical transfer pathway; other site
224308006390	diiron center [ion binding]; other site
224308006391	tyrosyl radical; other site
224308006392	HNH endonuclease; Region: HNH_3; pfam13392
224308006393	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
224308006394	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
224308006395	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
224308006396	protein-splicing catalytic site; other site
224308006397	thioester formation/cholesterol transfer; other site
224308006398	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
224308006399	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
224308006400	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
224308006401	ribonucleoside-diphosphate reductase 2, operon protein nrdI; Region: nrdI; TIGR00333
224308006402	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
224308006403	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
224308006404	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
224308006405	cofactor binding site; other site
224308006406	DNA binding site [nucleotide binding]
224308006407	substrate interaction site [chemical binding]; other site
224308006408	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
224308006409	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
224308006410	AAA domain; Region: AAA_33; pfam13671
224308006411	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
224308006412	active site
224308006413	YorP protein; Region: YorP; pfam09629
224308006414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
224308006415	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
224308006416	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
224308006417	active site
224308006418	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
224308006419	DHH family; Region: DHH; pfam01368
224308006420	hypothetical protein; Provisional; Region: PRK08624
224308006421	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
224308006422	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
224308006423	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
224308006424	ATP binding site [chemical binding]; other site
224308006425	Walker B motif; other site
224308006426	AAA domain; Region: AAA_24; pfam13479
224308006427	Right handed beta helix region; Region: Beta_helix; pfam13229
224308006428	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
224308006429	Phage-related replication protein [General function prediction only]; Region: COG4195
224308006430	Uncharacterized conserved protein [Function unknown]; Region: COG2135
224308006431	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636
224308006432	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
224308006433	active site
224308006434	DNA binding site [nucleotide binding]
224308006435	YoqO-like protein; Region: YoqO; pfam14037
224308006436	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
224308006437	active site
224308006438	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4474
224308006439	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
224308006440	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
224308006441	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
224308006442	YopX protein; Region: YopX; pfam09643
224308006443	Hypothetical protein Yopt; Region: Yopt; pfam09467
224308006444	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308006445	salt bridge; other site
224308006446	non-specific DNA binding site [nucleotide binding]; other site
224308006447	sequence-specific DNA binding site [nucleotide binding]; other site
224308006448	DNA-sulfur modification-associated; Region: DndB; pfam14072
224308006449	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
224308006450	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
224308006451	active site
224308006452	catalytic residues [active]
224308006453	DNA binding site [nucleotide binding]
224308006454	Int/Topo IB signature motif; other site
224308006455	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308006456	non-specific DNA binding site [nucleotide binding]; other site
224308006457	salt bridge; other site
224308006458	sequence-specific DNA binding site [nucleotide binding]; other site
224308006459	Superinfection exclusion protein B; Region: SieB; pfam14163
224308006460	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
224308006461	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
224308006462	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
224308006463	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308006464	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308006465	non-specific DNA binding site [nucleotide binding]; other site
224308006466	salt bridge; other site
224308006467	sequence-specific DNA binding site [nucleotide binding]; other site
224308006468	RNA dependent RNA polymerase; Region: RdRP; pfam05183
224308006469	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
224308006470	IHF - DNA interface [nucleotide binding]; other site
224308006471	IHF dimer interface [polypeptide binding]; other site
224308006472	YonK protein; Region: YonK; pfam09642
224308006473	Terminase-like family; Region: Terminase_6; pfam03237
224308006474	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
224308006475	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693
224308006476	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
224308006477	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
224308006478	active site
224308006479	catalytic residues [active]
224308006480	DNA binding site [nucleotide binding]
224308006481	Int/Topo IB signature motif; other site
224308006482	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
224308006483	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
224308006484	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224308006485	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224308006486	catalytic residue [active]
224308006487	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
224308006488	Peptidase family M23; Region: Peptidase_M23; pfam01551
224308006489	Phage-related protein [Function unknown]; Region: COG4722
224308006490	Phage tail protein; Region: Sipho_tail; cl17486
224308006491	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
224308006492	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
224308006493	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
224308006494	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
224308006495	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
224308006496	amidase catalytic site [active]
224308006497	Zn binding residues [ion binding]; other site
224308006498	substrate binding site [chemical binding]; other site
224308006499	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
224308006500	holin, SPP1 family; Region: holin_SPP1; TIGR01592
224308006501	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
224308006502	peptide S-glycosyltransferase, SunS family; Region: S_glycosyl_SunS; TIGR04195
224308006503	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
224308006504	active site
224308006505	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224308006506	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
224308006507	catalytic residues [active]
224308006508	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
224308006509	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
224308006510	putative active site [active]
224308006511	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308006512	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
224308006513	Walker A/P-loop; other site
224308006514	ATP binding site [chemical binding]; other site
224308006515	Q-loop/lid; other site
224308006516	ABC transporter signature motif; other site
224308006517	Walker B; other site
224308006518	D-loop; other site
224308006519	H-loop/switch region; other site
224308006520	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
224308006521	DNA polymerase IV; Reviewed; Region: PRK03103
224308006522	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
224308006523	active site
224308006524	DNA binding site [nucleotide binding]
224308006525	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
224308006526	YolD-like protein; Region: YolD; pfam08863
224308006527	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224308006528	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308006529	Coenzyme A binding pocket [chemical binding]; other site
224308006530	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
224308006531	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
224308006532	Uncharacterized conserved protein [Function unknown]; Region: COG5444
224308006533	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
224308006534	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308006535	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308006536	Staphylococcal nuclease homologues; Region: SNc; smart00318
224308006537	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
224308006538	Catalytic site; other site
224308006539	Excalibur calcium-binding domain; Region: Excalibur; smart00894
224308006540	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
224308006541	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
224308006542	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
224308006543	catalytic residues [active]
224308006544	catalytic nucleophile [active]
224308006545	Recombinase; Region: Recombinase; pfam07508
224308006546	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308006547	methionine sulfoxide reductase B; Provisional; Region: PRK00222
224308006548	SelR domain; Region: SelR; pfam01641
224308006549	methionine sulfoxide reductase A; Provisional; Region: PRK14054
224308006550	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308006551	MarR family; Region: MarR; pfam01047
224308006552	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
224308006553	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
224308006554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
224308006555	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
224308006556	active site
224308006557	catalytic triad [active]
224308006558	oxyanion hole [active]
224308006559	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
224308006560	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
224308006561	Cu(I) binding site [ion binding]; other site
224308006562	Protein of unknown function (DUF2535); Region: DUF2535; pfam10751
224308006563	threonine dehydratase; Validated; Region: PRK08639
224308006564	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
224308006565	tetramer interface [polypeptide binding]; other site
224308006566	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308006567	catalytic residue [active]
224308006568	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
224308006569	putative Ile/Val binding site [chemical binding]; other site
224308006570	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308006571	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
224308006572	Walker A motif; other site
224308006573	ATP binding site [chemical binding]; other site
224308006574	Walker B motif; other site
224308006575	arginine finger; other site
224308006576	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
224308006577	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
224308006578	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
224308006579	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
224308006580	putative acyl-acceptor binding pocket; other site
224308006581	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
224308006582	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
224308006583	folate binding site [chemical binding]; other site
224308006584	NADP+ binding site [chemical binding]; other site
224308006585	thymidylate synthase; Reviewed; Region: thyA; PRK01827
224308006586	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
224308006587	dimerization interface [polypeptide binding]; other site
224308006588	active site
224308006589	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
224308006590	tetramer interfaces [polypeptide binding]; other site
224308006591	binuclear metal-binding site [ion binding]; other site
224308006592	YpjP-like protein; Region: YpjP; pfam14005
224308006593	ribosomal biogenesis protein; Validated; Region: PRK00933
224308006594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308006595	S-adenosylmethionine binding site [chemical binding]; other site
224308006596	Disulphide isomerase; Region: Disulph_isomer; pfam06491
224308006597	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
224308006598	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
224308006599	Virulence factor; Region: Virulence_fact; pfam13769
224308006600	HEAT repeats; Region: HEAT_2; pfam13646
224308006601	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
224308006602	HEAT repeats; Region: HEAT_2; pfam13646
224308006603	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
224308006604	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
224308006605	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224308006606	Zn2+ binding site [ion binding]; other site
224308006607	Mg2+ binding site [ion binding]; other site
224308006608	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
224308006609	catalytic residues [active]
224308006610	dimer interface [polypeptide binding]; other site
224308006611	homoserine O-succinyltransferase; Provisional; Region: PRK05368
224308006612	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
224308006613	proposed active site lysine [active]
224308006614	conserved cys residue [active]
224308006615	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
224308006616	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
224308006617	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
224308006618	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
224308006619	DNA-binding site [nucleotide binding]; DNA binding site
224308006620	RNA-binding motif; other site
224308006621	Protein of unknown function (DUF2564); Region: DUF2564; pfam10819
224308006622	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
224308006623	hypothetical protein; Validated; Region: PRK07708
224308006624	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
224308006625	RNA/DNA hybrid binding site [nucleotide binding]; other site
224308006626	active site
224308006627	conserved hypothetical integral membrane protein; Region: TIGR00697
224308006628	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
224308006629	RNA/DNA hybrid binding site [nucleotide binding]; other site
224308006630	active site
224308006631	small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093
224308006632	5'-3' exonuclease; Region: 53EXOc; smart00475
224308006633	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
224308006634	active site
224308006635	metal binding site 1 [ion binding]; metal-binding site
224308006636	putative 5' ssDNA interaction site; other site
224308006637	metal binding site 3; metal-binding site
224308006638	metal binding site 2 [ion binding]; metal-binding site
224308006639	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
224308006640	putative DNA binding site [nucleotide binding]; other site
224308006641	putative metal binding site [ion binding]; other site
224308006642	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
224308006643	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
224308006644	Dynamin family; Region: Dynamin_N; pfam00350
224308006645	G1 box; other site
224308006646	GTP/Mg2+ binding site [chemical binding]; other site
224308006647	G2 box; other site
224308006648	Switch I region; other site
224308006649	G3 box; other site
224308006650	Switch II region; other site
224308006651	G4 box; other site
224308006652	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
224308006653	G1 box; other site
224308006654	GTP/Mg2+ binding site [chemical binding]; other site
224308006655	Dynamin family; Region: Dynamin_N; pfam00350
224308006656	G2 box; other site
224308006657	Switch I region; other site
224308006658	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
224308006659	G3 box; other site
224308006660	Switch II region; other site
224308006661	GTP/Mg2+ binding site [chemical binding]; other site
224308006662	G4 box; other site
224308006663	G5 box; other site
224308006664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
224308006665	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
224308006666	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
224308006667	malonyl-CoA binding site [chemical binding]; other site
224308006668	dimer interface [polypeptide binding]; other site
224308006669	active site
224308006670	product binding site; other site
224308006671	xanthine permease; Region: pbuX; TIGR03173
224308006672	Sulfate transporter family; Region: Sulfate_transp; pfam00916
224308006673	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308006674	active site
224308006675	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
224308006676	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
224308006677	active site
224308006678	Zn binding site [ion binding]; other site
224308006679	2-keto-3-deoxygluconate permease; Region: KdgT; pfam03812
224308006680	Entner-Doudoroff aldolase; Region: eda; TIGR01182
224308006681	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
224308006682	active site
224308006683	intersubunit interface [polypeptide binding]; other site
224308006684	catalytic residue [active]
224308006685	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224308006686	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
224308006687	substrate binding site [chemical binding]; other site
224308006688	ATP binding site [chemical binding]; other site
224308006689	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308006690	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308006691	DNA binding site [nucleotide binding]
224308006692	domain linker motif; other site
224308006693	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
224308006694	putative dimerization interface [polypeptide binding]; other site
224308006695	putative ligand binding site [chemical binding]; other site
224308006696	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
224308006697	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
224308006698	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
224308006699	NADP binding site [chemical binding]; other site
224308006700	homodimer interface [polypeptide binding]; other site
224308006701	active site
224308006702	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
224308006703	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
224308006704	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
224308006705	YpzG-like protein; Region: YpzG; pfam14139
224308006706	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
224308006707	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
224308006708	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
224308006709	cell division protein GpsB; Provisional; Region: PRK14127
224308006710	DivIVA domain; Region: DivI1A_domain; TIGR03544
224308006711	hypothetical protein; Provisional; Region: PRK13660
224308006712	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
224308006713	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
224308006714	RNase_H superfamily; Region: RNase_H_2; pfam13482
224308006715	active site
224308006716	substrate binding site [chemical binding]; other site
224308006717	Tetratricopeptide repeat; Region: TPR_16; pfam13432
224308006718	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
224308006719	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308006720	ATP binding site [chemical binding]; other site
224308006721	putative Mg++ binding site [ion binding]; other site
224308006722	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308006723	nucleotide binding region [chemical binding]; other site
224308006724	ATP-binding site [chemical binding]; other site
224308006725	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
224308006726	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
224308006727	HPr interaction site; other site
224308006728	glycerol kinase (GK) interaction site [polypeptide binding]; other site
224308006729	active site
224308006730	phosphorylation site [posttranslational modification]
224308006731	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
224308006732	YppG-like protein; Region: YppG; pfam14179
224308006733	YppF-like protein; Region: YppF; pfam14178
224308006734	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
224308006735	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
224308006736	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
224308006737	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
224308006738	Transglycosylase; Region: Transgly; pfam00912
224308006739	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224308006740	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
224308006741	Interdomain contacts; other site
224308006742	Cytokine receptor motif; other site
224308006743	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
224308006744	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224308006745	minor groove reading motif; other site
224308006746	helix-hairpin-helix signature motif; other site
224308006747	substrate binding pocket [chemical binding]; other site
224308006748	active site
224308006749	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
224308006750	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
224308006751	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
224308006752	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
224308006753	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
224308006754	putative dimer interface [polypeptide binding]; other site
224308006755	putative anticodon binding site; other site
224308006756	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
224308006757	homodimer interface [polypeptide binding]; other site
224308006758	motif 1; other site
224308006759	motif 2; other site
224308006760	active site
224308006761	motif 3; other site
224308006762	aspartate aminotransferase; Provisional; Region: PRK05764
224308006763	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308006764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308006765	homodimer interface [polypeptide binding]; other site
224308006766	catalytic residue [active]
224308006767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
224308006768	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
224308006769	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
224308006770	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
224308006771	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
224308006772	active site
224308006773	catalytic site [active]
224308006774	substrate binding site [chemical binding]; other site
224308006775	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
224308006776	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
224308006777	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
224308006778	tetramerization interface [polypeptide binding]; other site
224308006779	active site
224308006780	pantoate--beta-alanine ligase; Region: panC; TIGR00018
224308006781	Pantoate-beta-alanine ligase; Region: PanC; cd00560
224308006782	active site
224308006783	ATP-binding site [chemical binding]; other site
224308006784	pantoate-binding site; other site
224308006785	HXXH motif; other site
224308006786	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
224308006787	oligomerization interface [polypeptide binding]; other site
224308006788	active site
224308006789	metal binding site [ion binding]; metal-binding site
224308006790	Biotin operon repressor [Transcription]; Region: BirA; COG1654
224308006791	birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121
224308006792	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
224308006793	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
224308006794	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
224308006795	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
224308006796	active site
224308006797	NTP binding site [chemical binding]; other site
224308006798	metal binding triad [ion binding]; metal-binding site
224308006799	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
224308006800	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
224308006801	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
224308006802	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
224308006803	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
224308006804	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
224308006805	active site
224308006806	dimer interfaces [polypeptide binding]; other site
224308006807	catalytic residues [active]
224308006808	dihydrodipicolinate reductase; Region: dapB; TIGR00036
224308006809	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
224308006810	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
224308006811	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
224308006812	homodimer interface [polypeptide binding]; other site
224308006813	metal binding site [ion binding]; metal-binding site
224308006814	Uncharacterized conserved protein [Function unknown]; Region: COG1284
224308006815	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308006816	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308006817	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
224308006818	Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577
224308006819	Predicted membrane protein [Function unknown]; Region: COG4347
224308006820	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
224308006821	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
224308006822	intrachain domain interface; other site
224308006823	Qi binding site; other site
224308006824	Qo binding site; other site
224308006825	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
224308006826	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
224308006827	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
224308006828	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
224308006829	interchain domain interface [polypeptide binding]; other site
224308006830	intrachain domain interface; other site
224308006831	heme bH binding site [chemical binding]; other site
224308006832	Qi binding site; other site
224308006833	heme bL binding site [chemical binding]; other site
224308006834	Qo binding site; other site
224308006835	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
224308006836	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
224308006837	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
224308006838	iron-sulfur cluster [ion binding]; other site
224308006839	[2Fe-2S] cluster binding site [ion binding]; other site
224308006840	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
224308006841	hypothetical protein; Provisional; Region: PRK03636
224308006842	UPF0302 domain; Region: UPF0302; pfam08864
224308006843	IDEAL domain; Region: IDEAL; pfam08858
224308006844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
224308006845	TPR motif; other site
224308006846	binding surface
224308006847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
224308006848	binding surface
224308006849	TPR motif; other site
224308006850	Tetratricopeptide repeat; Region: TPR_16; pfam13432
224308006851	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308006852	TPR motif; other site
224308006853	binding surface
224308006854	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
224308006855	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308006856	binding surface
224308006857	TPR motif; other site
224308006858	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
224308006859	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
224308006860	hinge; other site
224308006861	active site
224308006862	prephenate dehydrogenase; Validated; Region: PRK06545
224308006863	prephenate dehydrogenase; Validated; Region: PRK08507
224308006864	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
224308006865	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
224308006866	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308006867	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308006868	homodimer interface [polypeptide binding]; other site
224308006869	catalytic residue [active]
224308006870	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
224308006871	substrate binding site [chemical binding]; other site
224308006872	active site
224308006873	catalytic residues [active]
224308006874	heterodimer interface [polypeptide binding]; other site
224308006875	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
224308006876	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
224308006877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308006878	catalytic residue [active]
224308006879	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
224308006880	active site
224308006881	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
224308006882	active site
224308006883	ribulose/triose binding site [chemical binding]; other site
224308006884	phosphate binding site [ion binding]; other site
224308006885	substrate (anthranilate) binding pocket [chemical binding]; other site
224308006886	product (indole) binding pocket [chemical binding]; other site
224308006887	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
224308006888	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
224308006889	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
224308006890	anthranilate synthase component I; Provisional; Region: PRK13569
224308006891	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
224308006892	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
224308006893	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
224308006894	homotrimer interaction site [polypeptide binding]; other site
224308006895	active site
224308006896	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
224308006897	active site
224308006898	dimer interface [polypeptide binding]; other site
224308006899	metal binding site [ion binding]; metal-binding site
224308006900	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
224308006901	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
224308006902	Tetramer interface [polypeptide binding]; other site
224308006903	active site
224308006904	FMN-binding site [chemical binding]; other site
224308006905	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
224308006906	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
224308006907	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
224308006908	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
224308006909	active site
224308006910	multimer interface [polypeptide binding]; other site
224308006911	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
224308006912	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
224308006913	substrate binding pocket [chemical binding]; other site
224308006914	chain length determination region; other site
224308006915	substrate-Mg2+ binding site; other site
224308006916	catalytic residues [active]
224308006917	aspartate-rich region 1; other site
224308006918	active site lid residues [active]
224308006919	aspartate-rich region 2; other site
224308006920	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
224308006921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308006922	S-adenosylmethionine binding site [chemical binding]; other site
224308006923	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
224308006924	Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081
224308006925	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
224308006926	homodecamer interface [polypeptide binding]; other site
224308006927	GTP cyclohydrolase I; Provisional; Region: PLN03044
224308006928	active site
224308006929	putative catalytic site residues [active]
224308006930	zinc binding site [ion binding]; other site
224308006931	GTP-CH-I/GFRP interaction surface; other site
224308006932	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
224308006933	IHF dimer interface [polypeptide binding]; other site
224308006934	IHF - DNA interface [nucleotide binding]; other site
224308006935	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
224308006936	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
224308006937	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
224308006938	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
224308006939	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
224308006940	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
224308006941	GTP-binding protein Der; Reviewed; Region: PRK00093
224308006942	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
224308006943	G1 box; other site
224308006944	GTP/Mg2+ binding site [chemical binding]; other site
224308006945	Switch I region; other site
224308006946	G2 box; other site
224308006947	Switch II region; other site
224308006948	G3 box; other site
224308006949	G4 box; other site
224308006950	G5 box; other site
224308006951	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
224308006952	G1 box; other site
224308006953	GTP/Mg2+ binding site [chemical binding]; other site
224308006954	Switch I region; other site
224308006955	G2 box; other site
224308006956	G3 box; other site
224308006957	Switch II region; other site
224308006958	G4 box; other site
224308006959	G5 box; other site
224308006960	YIEGIA protein; Region: YIEGIA; pfam14045
224308006961	YpzI-like protein; Region: YpzI; pfam14140
224308006962	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
224308006963	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
224308006964	homotetramer interface [polypeptide binding]; other site
224308006965	FMN binding site [chemical binding]; other site
224308006966	homodimer contacts [polypeptide binding]; other site
224308006967	putative active site [active]
224308006968	putative substrate binding site [chemical binding]; other site
224308006969	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
224308006970	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
224308006971	RNA binding site [nucleotide binding]; other site
224308006972	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
224308006973	RNA binding site [nucleotide binding]; other site
224308006974	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
224308006975	RNA binding site [nucleotide binding]; other site
224308006976	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
224308006977	RNA binding site [nucleotide binding]; other site
224308006978	cytidylate kinase; Provisional; Region: cmk; PRK00023
224308006979	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
224308006980	CMP-binding site; other site
224308006981	The sites determining sugar specificity; other site
224308006982	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
224308006983	Flagellar protein YcgR; Region: YcgR_2; pfam12945
224308006984	PilZ domain; Region: PilZ; pfam07238
224308006985	germination protein YpeB; Region: spore_YpeB; TIGR02889
224308006986	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308006987	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
224308006988	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
224308006989	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
224308006990	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
224308006991	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308006992	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
224308006993	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
224308006994	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
224308006995	NAD(P) binding site [chemical binding]; other site
224308006996	adaptor protein; Provisional; Region: PRK02899
224308006997	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
224308006998	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224308006999	putative active site [active]
224308007000	putative metal binding site [ion binding]; other site
224308007001	Protein of unknown function (DUF2663); Region: DUF2663; pfam10864
224308007002	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308007003	CAAX protease self-immunity; Region: Abi; pfam02517
224308007004	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
224308007005	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308007006	ATP binding site [chemical binding]; other site
224308007007	putative Mg++ binding site [ion binding]; other site
224308007008	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308007009	nucleotide binding region [chemical binding]; other site
224308007010	ATP-binding site [chemical binding]; other site
224308007011	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
224308007012	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
224308007013	Predicted membrane protein [Function unknown]; Region: COG3601
224308007014	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
224308007015	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
224308007016	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
224308007017	ligand binding site [chemical binding]; other site
224308007018	NAD binding site [chemical binding]; other site
224308007019	dimerization interface [polypeptide binding]; other site
224308007020	catalytic site [active]
224308007021	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
224308007022	putative L-serine binding site [chemical binding]; other site
224308007023	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
224308007024	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
224308007025	active site
224308007026	catalytic residue [active]
224308007027	dimer interface [polypeptide binding]; other site
224308007028	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
224308007029	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308007030	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308007031	DNA binding residues [nucleotide binding]
224308007032	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
224308007033	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308007034	dimerization interface [polypeptide binding]; other site
224308007035	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308007036	putative active site [active]
224308007037	heme pocket [chemical binding]; other site
224308007038	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308007039	dimer interface [polypeptide binding]; other site
224308007040	phosphorylation site [posttranslational modification]
224308007041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308007042	ATP binding site [chemical binding]; other site
224308007043	Mg2+ binding site [ion binding]; other site
224308007044	G-X-G motif; other site
224308007045	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308007046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308007047	active site
224308007048	phosphorylation site [posttranslational modification]
224308007049	intermolecular recognition site; other site
224308007050	dimerization interface [polypeptide binding]; other site
224308007051	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308007052	DNA binding site [nucleotide binding]
224308007053	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
224308007054	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
224308007055	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
224308007056	ResB-like family; Region: ResB; pfam05140
224308007057	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
224308007058	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
224308007059	catalytic residues [active]
224308007060	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
224308007061	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308007062	RNA binding surface [nucleotide binding]; other site
224308007063	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
224308007064	active site
224308007065	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
224308007066	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
224308007067	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
224308007068	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
224308007069	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
224308007070	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
224308007071	segregation and condensation protein B; Region: TIGR00281
224308007072	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
224308007073	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
224308007074	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308007075	Coenzyme A binding pocket [chemical binding]; other site
224308007076	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
224308007077	homopentamer interface [polypeptide binding]; other site
224308007078	active site
224308007079	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
224308007080	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
224308007081	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
224308007082	dimerization interface [polypeptide binding]; other site
224308007083	active site
224308007084	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
224308007085	Lumazine binding domain; Region: Lum_binding; pfam00677
224308007086	Lumazine binding domain; Region: Lum_binding; pfam00677
224308007087	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
224308007088	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
224308007089	catalytic motif [active]
224308007090	Zn binding site [ion binding]; other site
224308007091	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
224308007092	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
224308007093	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224308007094	Catalytic site [active]
224308007095	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855
224308007096	Evidence 5: No homology to any previously reported sequences
224308007097	Evidence 5: No homology to any previously reported sequences; PubMedId: 15849754, 16850406
224308007098	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
224308007099	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
224308007100	active site
224308007101	Predicted secreted protein [Function unknown]; Region: COG4086
224308007102	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
224308007103	diaminopimelate decarboxylase; Region: lysA; TIGR01048
224308007104	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
224308007105	active site
224308007106	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224308007107	substrate binding site [chemical binding]; other site
224308007108	catalytic residues [active]
224308007109	dimer interface [polypeptide binding]; other site
224308007110	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
224308007111	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
224308007112	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
224308007113	stage V sporulation protein AD; Validated; Region: PRK08304
224308007114	stage V sporulation protein AD; Provisional; Region: PRK12404
224308007115	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
224308007116	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
224308007117	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
224308007118	sporulation sigma factor SigF; Validated; Region: PRK05572
224308007119	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308007120	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224308007121	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308007122	DNA binding residues [nucleotide binding]
224308007123	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
224308007124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308007125	ATP binding site [chemical binding]; other site
224308007126	Mg2+ binding site [ion binding]; other site
224308007127	G-X-G motif; other site
224308007128	anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886
224308007129	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
224308007130	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
224308007131	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
224308007132	purine nucleoside phosphorylase; Provisional; Region: PRK08202
224308007133	phosphopentomutase; Provisional; Region: PRK05362
224308007134	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
224308007135	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
224308007136	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
224308007137	active site
224308007138	Int/Topo IB signature motif; other site
224308007139	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
224308007140	ferric uptake regulator; Provisional; Region: fur; PRK09462
224308007141	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
224308007142	metal binding site 2 [ion binding]; metal-binding site
224308007143	putative DNA binding helix; other site
224308007144	metal binding site 1 [ion binding]; metal-binding site
224308007145	dimer interface [polypeptide binding]; other site
224308007146	structural Zn2+ binding site [ion binding]; other site
224308007147	stage II sporulation protein M; Region: spo_II_M; TIGR02831
224308007148	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
224308007149	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
224308007150	Malic enzyme, N-terminal domain; Region: malic; pfam00390
224308007151	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
224308007152	NAD(P) binding pocket [chemical binding]; other site
224308007153	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
224308007154	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
224308007155	Aspartase; Region: Aspartase; cd01357
224308007156	active sites [active]
224308007157	tetramer interface [polypeptide binding]; other site
224308007158	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
224308007159	active site
224308007160	homodimer interface [polypeptide binding]; other site
224308007161	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308007162	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308007163	non-specific DNA binding site [nucleotide binding]; other site
224308007164	salt bridge; other site
224308007165	sequence-specific DNA binding site [nucleotide binding]; other site
224308007166	TIGR00375 family protein; Region: TIGR00375
224308007167	PHP-associated; Region: PHP_C; pfam13263
224308007168	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
224308007169	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
224308007170	dimer interface [polypeptide binding]; other site
224308007171	ADP-ribose binding site [chemical binding]; other site
224308007172	active site
224308007173	nudix motif; other site
224308007174	metal binding site [ion binding]; metal-binding site
224308007175	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224308007176	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
224308007177	active site
224308007178	catalytic tetrad [active]
224308007179	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
224308007180	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
224308007181	Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705
224308007182	Protein of unknown function (DUF2552); Region: DUF2552; pfam10827
224308007183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
224308007184	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
224308007185	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308007186	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
224308007187	Coenzyme A binding pocket [chemical binding]; other site
224308007188	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
224308007189	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
224308007190	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
224308007191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308007192	Coenzyme A binding pocket [chemical binding]; other site
224308007193	YolD-like protein; Region: YolD; pfam08863
224308007194	DNA polymerase IV; Reviewed; Region: PRK03103
224308007195	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
224308007196	active site
224308007197	DNA binding site [nucleotide binding]
224308007198	YqzH-like protein; Region: YqzH; pfam14164
224308007199	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308007200	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308007201	putative substrate translocation pore; other site
224308007202	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
224308007203	putative dimer interface [polypeptide binding]; other site
224308007204	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308007205	ligand binding site [chemical binding]; other site
224308007206	Zn binding site [ion binding]; other site
224308007207	pantothenate kinase; Provisional; Region: PRK05439
224308007208	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
224308007209	ATP-binding site [chemical binding]; other site
224308007210	CoA-binding site [chemical binding]; other site
224308007211	Mg2+-binding site [ion binding]; other site
224308007212	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
224308007213	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
224308007214	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224308007215	catalytic residue [active]
224308007216	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
224308007217	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
224308007218	NADP binding site [chemical binding]; other site
224308007219	homodimer interface [polypeptide binding]; other site
224308007220	substrate binding site [chemical binding]; other site
224308007221	active site
224308007222	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
224308007223	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
224308007224	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
224308007225	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
224308007226	putative metal binding site [ion binding]; other site
224308007227	putative dimer interface [polypeptide binding]; other site
224308007228	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
224308007229	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
224308007230	active site
224308007231	FMN binding site [chemical binding]; other site
224308007232	substrate binding site [chemical binding]; other site
224308007233	homotetramer interface [polypeptide binding]; other site
224308007234	catalytic residue [active]
224308007235	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
224308007236	putative hydrolase; Provisional; Region: PRK02113
224308007237	ribonuclease Z; Region: RNase_Z; TIGR02651
224308007238	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
224308007239	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
224308007240	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
224308007241	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
224308007242	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
224308007243	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
224308007244	DNA polymerase IV; Validated; Region: PRK01810
224308007245	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
224308007246	active site
224308007247	DNA binding site [nucleotide binding]
224308007248	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
224308007249	OxaA-like protein precursor; Validated; Region: PRK01622
224308007250	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
224308007251	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
224308007252	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
224308007253	peptidase T-like protein; Region: PepT-like; TIGR01883
224308007254	metal binding site [ion binding]; metal-binding site
224308007255	putative dimer interface [polypeptide binding]; other site
224308007256	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
224308007257	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
224308007258	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
224308007259	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308007260	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
224308007261	dimer interface [polypeptide binding]; other site
224308007262	substrate binding site [chemical binding]; other site
224308007263	metal binding site [ion binding]; metal-binding site
224308007264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
224308007265	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
224308007266	Predicted membrane protein [Function unknown]; Region: COG4129
224308007267	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
224308007268	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
224308007269	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224308007270	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
224308007271	Walker A/P-loop; other site
224308007272	ATP binding site [chemical binding]; other site
224308007273	Q-loop/lid; other site
224308007274	ABC transporter signature motif; other site
224308007275	Walker B; other site
224308007276	D-loop; other site
224308007277	H-loop/switch region; other site
224308007278	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
224308007279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308007280	dimer interface [polypeptide binding]; other site
224308007281	conserved gate region; other site
224308007282	putative PBP binding loops; other site
224308007283	ABC-ATPase subunit interface; other site
224308007284	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224308007285	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
224308007286	substrate binding pocket [chemical binding]; other site
224308007287	membrane-bound complex binding site; other site
224308007288	hinge residues; other site
224308007289	Disulphide isomerase; Region: Disulph_isomer; pfam06491
224308007290	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
224308007291	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
224308007292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308007293	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308007294	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
224308007295	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
224308007296	DNA binding residues [nucleotide binding]
224308007297	drug binding residues [chemical binding]; other site
224308007298	dimer interface [polypeptide binding]; other site
224308007299	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
224308007300	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
224308007301	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
224308007302	E3 interaction surface; other site
224308007303	lipoyl attachment site [posttranslational modification]; other site
224308007304	e3 binding domain; Region: E3_binding; pfam02817
224308007305	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
224308007306	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
224308007307	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
224308007308	alpha subunit interface [polypeptide binding]; other site
224308007309	TPP binding site [chemical binding]; other site
224308007310	heterodimer interface [polypeptide binding]; other site
224308007311	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224308007312	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
224308007313	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
224308007314	tetramer interface [polypeptide binding]; other site
224308007315	TPP-binding site [chemical binding]; other site
224308007316	heterodimer interface [polypeptide binding]; other site
224308007317	phosphorylation loop region [posttranslational modification]
224308007318	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
224308007319	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
224308007320	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308007321	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
224308007322	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224308007323	nucleotide binding site [chemical binding]; other site
224308007324	Acetokinase family; Region: Acetate_kinase; cl17229
224308007325	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
224308007326	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
224308007327	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
224308007328	NAD binding site [chemical binding]; other site
224308007329	Phe binding site; other site
224308007330	phosphate butyryltransferase; Validated; Region: PRK07742
224308007331	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
224308007332	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308007333	putative active site [active]
224308007334	heme pocket [chemical binding]; other site
224308007335	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308007336	putative active site [active]
224308007337	heme pocket [chemical binding]; other site
224308007338	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308007339	Walker A motif; other site
224308007340	ATP binding site [chemical binding]; other site
224308007341	Walker B motif; other site
224308007342	arginine finger; other site
224308007343	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
224308007344	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
224308007345	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
224308007346	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
224308007347	tetramer interface [polypeptide binding]; other site
224308007348	active site
224308007349	Mg2+/Mn2+ binding site [ion binding]; other site
224308007350	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
224308007351	2-methylcitrate dehydratase; Region: prpD; TIGR02330
224308007352	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
224308007353	dimer interface [polypeptide binding]; other site
224308007354	Citrate synthase; Region: Citrate_synt; pfam00285
224308007355	active site
224308007356	coenzyme A binding site [chemical binding]; other site
224308007357	citrylCoA binding site [chemical binding]; other site
224308007358	oxalacetate/citrate binding site [chemical binding]; other site
224308007359	catalytic triad [active]
224308007360	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224308007361	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
224308007362	FAD binding site [chemical binding]; other site
224308007363	homotetramer interface [polypeptide binding]; other site
224308007364	substrate binding pocket [chemical binding]; other site
224308007365	catalytic base [active]
224308007366	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
224308007367	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
224308007368	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
224308007369	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
224308007370	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
224308007371	dimer interface [polypeptide binding]; other site
224308007372	active site
224308007373	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
224308007374	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
224308007375	active site
224308007376	catalytic site [active]
224308007377	metal binding site [ion binding]; metal-binding site
224308007378	dimer interface [polypeptide binding]; other site
224308007379	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
224308007380	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
224308007381	active site
224308007382	metal binding site [ion binding]; metal-binding site
224308007383	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
224308007384	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
224308007385	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
224308007386	putative active site [active]
224308007387	putative FMN binding site [chemical binding]; other site
224308007388	putative substrate binding site [chemical binding]; other site
224308007389	putative catalytic residue [active]
224308007390	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
224308007391	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308007392	active site
224308007393	phosphorylation site [posttranslational modification]
224308007394	intermolecular recognition site; other site
224308007395	dimerization interface [polypeptide binding]; other site
224308007396	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
224308007397	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
224308007398	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
224308007399	protein binding site [polypeptide binding]; other site
224308007400	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
224308007401	DNA repair protein RecN; Region: recN; TIGR00634
224308007402	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
224308007403	Walker A/P-loop; other site
224308007404	ATP binding site [chemical binding]; other site
224308007405	Q-loop/lid; other site
224308007406	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
224308007407	ABC transporter signature motif; other site
224308007408	Walker B; other site
224308007409	D-loop; other site
224308007410	H-loop/switch region; other site
224308007411	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
224308007412	arginine repressor; Provisional; Region: PRK04280
224308007413	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
224308007414	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
224308007415	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308007416	RNA binding surface [nucleotide binding]; other site
224308007417	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
224308007418	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
224308007419	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
224308007420	TPP-binding site; other site
224308007421	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
224308007422	PYR/PP interface [polypeptide binding]; other site
224308007423	dimer interface [polypeptide binding]; other site
224308007424	TPP binding site [chemical binding]; other site
224308007425	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224308007426	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
224308007427	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
224308007428	substrate binding pocket [chemical binding]; other site
224308007429	chain length determination region; other site
224308007430	substrate-Mg2+ binding site; other site
224308007431	catalytic residues [active]
224308007432	aspartate-rich region 1; other site
224308007433	active site lid residues [active]
224308007434	aspartate-rich region 2; other site
224308007435	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063
224308007436	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
224308007437	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
224308007438	generic binding surface II; other site
224308007439	generic binding surface I; other site
224308007440	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
224308007441	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
224308007442	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
224308007443	homodimer interface [polypeptide binding]; other site
224308007444	NADP binding site [chemical binding]; other site
224308007445	substrate binding site [chemical binding]; other site
224308007446	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
224308007447	putative RNA binding site [nucleotide binding]; other site
224308007448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
224308007449	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
224308007450	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224308007451	ATP-grasp domain; Region: ATP-grasp_4; cl17255
224308007452	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
224308007453	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
224308007454	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224308007455	carboxyltransferase (CT) interaction site; other site
224308007456	biotinylation site [posttranslational modification]; other site
224308007457	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
224308007458	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
224308007459	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
224308007460	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
224308007461	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
224308007462	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
224308007463	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
224308007464	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
224308007465	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308007466	Walker A motif; other site
224308007467	ATP binding site [chemical binding]; other site
224308007468	Walker B motif; other site
224308007469	arginine finger; other site
224308007470	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
224308007471	elongation factor P; Validated; Region: PRK00529
224308007472	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
224308007473	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
224308007474	RNA binding site [nucleotide binding]; other site
224308007475	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
224308007476	RNA binding site [nucleotide binding]; other site
224308007477	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
224308007478	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
224308007479	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
224308007480	active site
224308007481	Dehydroquinase class II; Region: DHquinase_II; pfam01220
224308007482	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
224308007483	trimer interface [polypeptide binding]; other site
224308007484	active site
224308007485	dimer interface [polypeptide binding]; other site
224308007486	Conserved membrane protein YqhR; Region: YqhR; pfam11085
224308007487	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
224308007488	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
224308007489	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
224308007490	active site
224308007491	nucleophile elbow; other site
224308007492	manganese transport transcriptional regulator; Provisional; Region: PRK03902
224308007493	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
224308007494	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
224308007495	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
224308007496	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
224308007497	active site residue [active]
224308007498	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
224308007499	tetramer interface [polypeptide binding]; other site
224308007500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308007501	catalytic residue [active]
224308007502	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
224308007503	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
224308007504	tetramer interface [polypeptide binding]; other site
224308007505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308007506	catalytic residue [active]
224308007507	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
224308007508	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
224308007509	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
224308007510	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
224308007511	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308007512	ATP binding site [chemical binding]; other site
224308007513	putative Mg++ binding site [ion binding]; other site
224308007514	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308007515	nucleotide binding region [chemical binding]; other site
224308007516	ATP-binding site [chemical binding]; other site
224308007517	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
224308007518	Anti-repressor SinI; Region: SinI; pfam08671
224308007519	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308007520	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308007521	non-specific DNA binding site [nucleotide binding]; other site
224308007522	salt bridge; other site
224308007523	sequence-specific DNA binding site [nucleotide binding]; other site
224308007524	Anti-repressor SinI; Region: SinI; pfam08671
224308007525	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
224308007526	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
224308007527	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224308007528	Catalytic site [active]
224308007529	YqxM protein; Region: YqxM_for_SipW; TIGR04087
224308007530	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
224308007531	YqzE-like protein; Region: YqzE; pfam14038
224308007532	ComG operon protein 7; Region: ComGG; pfam14173
224308007533	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
224308007534	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
224308007535	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
224308007536	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
224308007537	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
224308007538	Type II/IV secretion system protein; Region: T2SE; pfam00437
224308007539	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
224308007540	Walker A motif; other site
224308007541	ATP binding site [chemical binding]; other site
224308007542	Walker B motif; other site
224308007543	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
224308007544	Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821
224308007545	Cl binding site [ion binding]; other site
224308007546	oligomer interface [polypeptide binding]; other site
224308007547	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
224308007548	Domain of unknown function DUF21; Region: DUF21; pfam01595
224308007549	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224308007550	Transporter associated domain; Region: CorC_HlyC; smart01091
224308007551	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
224308007552	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
224308007553	ArsC family; Region: ArsC; pfam03960
224308007554	putative catalytic residues [active]
224308007555	thiol/disulfide switch; other site
224308007556	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
224308007557	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224308007558	Protein of unknown function (DUF2759); Region: DUF2759; pfam10958
224308007559	Uncharacterized conserved protein [Function unknown]; Region: COG0011
224308007560	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
224308007561	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
224308007562	putative active site [active]
224308007563	Zn binding site [ion binding]; other site
224308007564	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
224308007565	Sulfatase; Region: Sulfatase; pfam00884
224308007566	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
224308007567	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224308007568	nucleotide binding site [chemical binding]; other site
224308007569	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
224308007570	Rhomboid family; Region: Rhomboid; pfam01694
224308007571	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308007572	binding surface
224308007573	TPR motif; other site
224308007574	TPR repeat; Region: TPR_11; pfam13414
224308007575	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
224308007576	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
224308007577	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
224308007578	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224308007579	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
224308007580	YceG-like family; Region: YceG; pfam02618
224308007581	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274
224308007582	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
224308007583	Walker A/P-loop; other site
224308007584	ATP binding site [chemical binding]; other site
224308007585	Q-loop/lid; other site
224308007586	ABC transporter signature motif; other site
224308007587	Walker B; other site
224308007588	D-loop; other site
224308007589	H-loop/switch region; other site
224308007590	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248
224308007591	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
224308007592	Walker A/P-loop; other site
224308007593	ATP binding site [chemical binding]; other site
224308007594	Q-loop/lid; other site
224308007595	ABC transporter signature motif; other site
224308007596	Walker B; other site
224308007597	D-loop; other site
224308007598	H-loop/switch region; other site
224308007599	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
224308007600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308007601	dimer interface [polypeptide binding]; other site
224308007602	conserved gate region; other site
224308007603	ABC-ATPase subunit interface; other site
224308007604	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
224308007605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308007606	dimer interface [polypeptide binding]; other site
224308007607	conserved gate region; other site
224308007608	putative PBP binding loops; other site
224308007609	ABC-ATPase subunit interface; other site
224308007610	PBP superfamily domain; Region: PBP_like_2; cl17296
224308007611	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
224308007612	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
224308007613	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
224308007614	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224308007615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308007616	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308007617	putative substrate translocation pore; other site
224308007618	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
224308007619	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
224308007620	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
224308007621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
224308007622	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
224308007623	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308007624	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
224308007625	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
224308007626	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
224308007627	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
224308007628	Uncharacterized conserved protein [Function unknown]; Region: COG5663
224308007629	ferric uptake regulator; Provisional; Region: fur; PRK09462
224308007630	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
224308007631	metal binding site 2 [ion binding]; metal-binding site
224308007632	putative DNA binding helix; other site
224308007633	metal binding site 1 [ion binding]; metal-binding site
224308007634	dimer interface [polypeptide binding]; other site
224308007635	structural Zn2+ binding site [ion binding]; other site
224308007636	Uncharacterized conserved protein [Function unknown]; Region: COG1284
224308007637	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308007638	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308007639	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
224308007640	Protein of unknown function (DUF2624); Region: DUF2624; pfam11116
224308007641	endonuclease IV; Provisional; Region: PRK01060
224308007642	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
224308007643	AP (apurinic/apyrimidinic) site pocket; other site
224308007644	DNA interaction; other site
224308007645	Metal-binding active site; metal-binding site
224308007646	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
224308007647	DEAD-like helicases superfamily; Region: DEXDc; smart00487
224308007648	ATP binding site [chemical binding]; other site
224308007649	Mg++ binding site [ion binding]; other site
224308007650	motif III; other site
224308007651	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308007652	nucleotide binding region [chemical binding]; other site
224308007653	ATP-binding site [chemical binding]; other site
224308007654	YqfQ-like protein; Region: YqfQ; pfam14181
224308007655	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
224308007656	LytB protein; Region: LYTB; pfam02401
224308007657	Uncharacterized conserved protein [Function unknown]; Region: COG0327
224308007658	dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486
224308007659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
224308007660	Uncharacterized conserved protein [Function unknown]; Region: COG0327
224308007661	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
224308007662	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
224308007663	Family of unknown function (DUF633); Region: DUF633; pfam04816
224308007664	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
224308007665	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
224308007666	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
224308007667	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
224308007668	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
224308007669	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308007670	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224308007671	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308007672	DNA binding residues [nucleotide binding]
224308007673	DNA primase; Validated; Region: dnaG; PRK05667
224308007674	CHC2 zinc finger; Region: zf-CHC2; pfam01807
224308007675	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
224308007676	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
224308007677	active site
224308007678	metal binding site [ion binding]; metal-binding site
224308007679	interdomain interaction site; other site
224308007680	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
224308007681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
224308007682	PEP synthetase regulatory protein; Provisional; Region: PRK05339
224308007683	HTH domain; Region: HTH_11; pfam08279
224308007684	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
224308007685	FOG: CBS domain [General function prediction only]; Region: COG0517
224308007686	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
224308007687	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
224308007688	dimer interface [polypeptide binding]; other site
224308007689	motif 1; other site
224308007690	active site
224308007691	motif 2; other site
224308007692	motif 3; other site
224308007693	Recombination protein O N terminal; Region: RecO_N; pfam11967
224308007694	DNA repair protein RecO; Region: reco; TIGR00613
224308007695	Recombination protein O C terminal; Region: RecO_C; pfam02565
224308007696	YqzL-like protein; Region: YqzL; pfam14006
224308007697	GTPase Era; Reviewed; Region: era; PRK00089
224308007698	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
224308007699	G1 box; other site
224308007700	GTP/Mg2+ binding site [chemical binding]; other site
224308007701	Switch I region; other site
224308007702	G2 box; other site
224308007703	Switch II region; other site
224308007704	G3 box; other site
224308007705	G4 box; other site
224308007706	G5 box; other site
224308007707	KH domain; Region: KH_2; pfam07650
224308007708	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
224308007709	active site
224308007710	catalytic motif [active]
224308007711	Zn binding site [ion binding]; other site
224308007712	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
224308007713	metal-binding heat shock protein; Provisional; Region: PRK00016
224308007714	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
224308007715	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
224308007716	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224308007717	Zn2+ binding site [ion binding]; other site
224308007718	Mg2+ binding site [ion binding]; other site
224308007719	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
224308007720	PhoH-like protein; Region: PhoH; pfam02562
224308007721	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
224308007722	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
224308007723	sporulation protein YqfC; Region: spore_yqfC; TIGR02856
224308007724	hypothetical protein; Provisional; Region: PRK13665
224308007725	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
224308007726	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
224308007727	dimer interface [polypeptide binding]; other site
224308007728	active site residues [active]
224308007729	Yqey-like protein; Region: YqeY; pfam09424
224308007730	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
224308007731	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
224308007732	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
224308007733	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
224308007734	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
224308007735	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
224308007736	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308007737	FeS/SAM binding site; other site
224308007738	TRAM domain; Region: TRAM; cl01282
224308007739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
224308007740	RNA methyltransferase, RsmE family; Region: TIGR00046
224308007741	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
224308007742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308007743	S-adenosylmethionine binding site [chemical binding]; other site
224308007744	chaperone protein DnaJ; Provisional; Region: PRK14280
224308007745	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
224308007746	HSP70 interaction site [polypeptide binding]; other site
224308007747	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
224308007748	substrate binding site [polypeptide binding]; other site
224308007749	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
224308007750	Zn binding sites [ion binding]; other site
224308007751	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
224308007752	dimer interface [polypeptide binding]; other site
224308007753	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
224308007754	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
224308007755	nucleotide binding site [chemical binding]; other site
224308007756	NEF interaction site [polypeptide binding]; other site
224308007757	SBD interface [polypeptide binding]; other site
224308007758	GrpE; Region: GrpE; pfam01025
224308007759	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
224308007760	dimer interface [polypeptide binding]; other site
224308007761	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
224308007762	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
224308007763	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
224308007764	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
224308007765	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308007766	FeS/SAM binding site; other site
224308007767	HemN C-terminal domain; Region: HemN_C; pfam06969
224308007768	GTP-binding protein LepA; Provisional; Region: PRK05433
224308007769	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
224308007770	G1 box; other site
224308007771	putative GEF interaction site [polypeptide binding]; other site
224308007772	GTP/Mg2+ binding site [chemical binding]; other site
224308007773	Switch I region; other site
224308007774	G2 box; other site
224308007775	G3 box; other site
224308007776	Switch II region; other site
224308007777	G4 box; other site
224308007778	G5 box; other site
224308007779	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
224308007780	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
224308007781	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
224308007782	Protein of unknown function (DUF3679); Region: DUF3679; pfam12438
224308007783	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
224308007784	stage II sporulation protein P; Region: spore_II_P; TIGR02867
224308007785	germination protease; Provisional; Region: PRK02858
224308007786	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
224308007787	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
224308007788	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
224308007789	YqzM-like protein; Region: YqzM; pfam14141
224308007790	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
224308007791	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
224308007792	Competence protein; Region: Competence; pfam03772
224308007793	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224308007794	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
224308007795	catalytic motif [active]
224308007796	Zn binding site [ion binding]; other site
224308007797	SLBB domain; Region: SLBB; pfam10531
224308007798	comEA protein; Region: comE; TIGR01259
224308007799	Helix-hairpin-helix motif; Region: HHH; pfam00633
224308007800	late competence protein ComER; Validated; Region: PRK07680
224308007801	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
224308007802	Methyltransferase domain; Region: Methyltransf_31; pfam13847
224308007803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308007804	S-adenosylmethionine binding site [chemical binding]; other site
224308007805	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
224308007806	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224308007807	Zn2+ binding site [ion binding]; other site
224308007808	Mg2+ binding site [ion binding]; other site
224308007809	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
224308007810	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
224308007811	active site
224308007812	(T/H)XGH motif; other site
224308007813	putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253
224308007814	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
224308007815	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
224308007816	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
224308007817	shikimate binding site; other site
224308007818	NAD(P) binding site [chemical binding]; other site
224308007819	GTPase YqeH; Provisional; Region: PRK13796
224308007820	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
224308007821	GTP/Mg2+ binding site [chemical binding]; other site
224308007822	G4 box; other site
224308007823	G5 box; other site
224308007824	G1 box; other site
224308007825	Switch I region; other site
224308007826	G2 box; other site
224308007827	G3 box; other site
224308007828	Switch II region; other site
224308007829	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
224308007830	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308007831	active site
224308007832	motif I; other site
224308007833	motif II; other site
224308007834	Sporulation inhibitor A; Region: Sda; pfam08970
224308007835	GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657
224308007836	active site
224308007837	catalytic triad [active]
224308007838	oxyanion hole [active]
224308007839	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
224308007840	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
224308007841	amidase catalytic site [active]
224308007842	Zn binding residues [ion binding]; other site
224308007843	substrate binding site [chemical binding]; other site
224308007844	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
224308007845	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308007846	Uncharacterized conserved protein [Function unknown]; Region: COG0398
224308007847	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
224308007848	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872
224308007849	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
224308007850	arginine decarboxylase; Provisional; Region: PRK15029
224308007851	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
224308007852	Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 15187183, 10974124; Product type r : regulator
224308007853	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
224308007854	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
224308007855	catalytic residues [active]
224308007856	catalytic nucleophile [active]
224308007857	Recombinase; Region: Recombinase; pfam07508
224308007858	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
224308007859	Low molecular weight phosphatase family; Region: LMWPc; cd00115
224308007860	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
224308007861	active site
224308007862	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
224308007863	arsenical-resistance protein; Region: acr3; TIGR00832
224308007864	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
224308007865	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308007866	putative metal binding site [ion binding]; other site
224308007867	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308007868	dimerization interface [polypeptide binding]; other site
224308007869	putative DNA binding site [nucleotide binding]; other site
224308007870	putative Zn2+ binding site [ion binding]; other site
224308007871	Uncharacterized conserved protein [Function unknown]; Region: COG3403
224308007872	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308007873	binding surface
224308007874	TPR motif; other site
224308007875	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308007876	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308007877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308007878	TPR motif; other site
224308007879	binding surface
224308007880	TPR repeat; Region: TPR_11; pfam13414
224308007881	Uncharacterized conserved protein [Function unknown]; Region: COG5444
224308007882	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
224308007883	HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410
224308007884	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
224308007885	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
224308007886	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
224308007887	amidase catalytic site [active]
224308007888	Zn binding residues [ion binding]; other site
224308007889	substrate binding site [chemical binding]; other site
224308007890	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
224308007891	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308007892	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
224308007893	phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669
224308007894	XkdW protein; Region: XkdW; pfam09636
224308007895	C1q domain; Region: C1q; cl17543
224308007896	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
224308007897	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
224308007898	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
224308007899	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
224308007900	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
224308007901	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308007902	Phage-related minor tail protein [Function unknown]; Region: COG5280
224308007903	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224308007904	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224308007905	catalytic residue [active]
224308007906	Evidence 4: Homologs of previously reported genes of unknown function
224308007907	Evidence 4: Homologs of previously reported genes of unknown function; PubMedId: 8760915, 8969508
224308007908	Protein of unknown function (DUF2001); Region: DUF2001; pfam09393
224308007909	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
224308007910	Domain of unknown function (DUF3599); Region: DUF3599; pfam12206
224308007911	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
224308007912	Phage capsid family; Region: Phage_capsid; pfam05065
224308007913	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
224308007914	Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518
224308007915	Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783
224308007916	Terminase-like family; Region: Terminase_6; pfam03237
224308007917	Uncharacterized conserved protein [Function unknown]; Region: COG5484
224308007918	Helix-turn-helix domain; Region: HTH_28; pfam13518
224308007919	Homeodomain-like domain; Region: HTH_23; cl17451
224308007920	Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570
224308007921	hypothetical protein; Provisional; Region: PRK06921
224308007922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308007923	Walker A motif; other site
224308007924	ATP binding site [chemical binding]; other site
224308007925	Walker B motif; other site
224308007926	arginine finger; other site
224308007927	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
224308007928	Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723
224308007929	Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377
224308007930	Hypothetical protein Yqai; Region: Yqai; pfam09466
224308007931	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308007932	non-specific DNA binding site [nucleotide binding]; other site
224308007933	salt bridge; other site
224308007934	sequence-specific DNA binding site [nucleotide binding]; other site
224308007935	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308007936	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308007937	non-specific DNA binding site [nucleotide binding]; other site
224308007938	salt bridge; other site
224308007939	sequence-specific DNA binding site [nucleotide binding]; other site
224308007940	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308007941	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308007942	non-specific DNA binding site [nucleotide binding]; other site
224308007943	salt bridge; other site
224308007944	sequence-specific DNA binding site [nucleotide binding]; other site
224308007945	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
224308007946	hypothetical protein; Validated; Region: PRK06217
224308007947	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
224308007948	Domain of unknown function (DUF955); Region: DUF955; pfam06114
224308007949	Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor
224308007950	Predicted membrane protein [Function unknown]; Region: COG3223
224308007951	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308007952	HAMP domain; Region: HAMP; pfam00672
224308007953	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308007954	dimer interface [polypeptide binding]; other site
224308007955	phosphorylation site [posttranslational modification]
224308007956	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
224308007957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308007958	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
224308007959	active site
224308007960	phosphorylation site [posttranslational modification]
224308007961	intermolecular recognition site; other site
224308007962	dimerization interface [polypeptide binding]; other site
224308007963	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308007964	DNA binding site [nucleotide binding]
224308007965	Predicted membrane protein [Function unknown]; Region: COG2311
224308007966	Protein of unknown function (DUF418); Region: DUF418; cl12135
224308007967	Protein of unknown function (DUF418); Region: DUF418; pfam04235
224308007968	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308007969	Coenzyme A binding pocket [chemical binding]; other site
224308007970	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
224308007971	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
224308007972	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
224308007973	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
224308007974	CPxP  motif; other site
224308007975	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
224308007976	active site residue [active]
224308007977	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224308007978	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
224308007979	CPxP  motif; other site
224308007980	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
224308007981	active site residue [active]
224308007982	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
224308007983	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
224308007984	putative homodimer interface [polypeptide binding]; other site
224308007985	putative homotetramer interface [polypeptide binding]; other site
224308007986	putative allosteric switch controlling residues; other site
224308007987	putative metal binding site [ion binding]; other site
224308007988	putative homodimer-homodimer interface [polypeptide binding]; other site
224308007989	Evidence 4: Homologs of previously reported genes of unknown function
224308007990	Evidence 5: No homology to any previously reported sequences
224308007991	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
224308007992	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224308007993	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
224308007994	DNA binding residues [nucleotide binding]
224308007995	dimer interface [polypeptide binding]; other site
224308007996	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
224308007997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308007998	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308007999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308008000	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
224308008001	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
224308008002	Coenzyme A binding pocket [chemical binding]; other site
224308008003	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
224308008004	Domain of unknown function DUF21; Region: DUF21; pfam01595
224308008005	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224308008006	Transporter associated domain; Region: CorC_HlyC; smart01091
224308008007	YrzO-like protein; Region: YrzO; pfam14142
224308008008	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224308008009	EamA-like transporter family; Region: EamA; pfam00892
224308008010	EamA-like transporter family; Region: EamA; pfam00892
224308008011	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308008012	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308008013	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
224308008014	putative dimerization interface [polypeptide binding]; other site
224308008015	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
224308008016	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
224308008017	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
224308008018	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
224308008019	Tautomerase enzyme; Region: Tautomerase; pfam01361
224308008020	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308008021	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308008022	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
224308008023	putative dimerization interface [polypeptide binding]; other site
224308008024	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
224308008025	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
224308008026	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
224308008027	4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346
224308008028	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
224308008029	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308008030	putative DNA binding site [nucleotide binding]; other site
224308008031	putative Zn2+ binding site [ion binding]; other site
224308008032	AsnC family; Region: AsnC_trans_reg; pfam01037
224308008033	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
224308008034	RNAase interaction site [polypeptide binding]; other site
224308008035	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
224308008036	Cytochrome P450; Region: p450; cl12078
224308008037	Evidence 4: Homologs of previously reported genes of unknown function
224308008038	Evidence 4: Homologs of previously reported genes of unknown function
224308008039	Evidence 4: Homologs of previously reported genes of unknown function
224308008040	Isochorismatase family; Region: Isochorismatase; pfam00857
224308008041	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
224308008042	catalytic triad [active]
224308008043	conserved cis-peptide bond; other site
224308008044	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
224308008045	DinB family; Region: DinB; pfam05163
224308008046	DinB superfamily; Region: DinB_2; pfam12867
224308008047	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
224308008048	Nitronate monooxygenase; Region: NMO; pfam03060
224308008049	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
224308008050	FMN binding site [chemical binding]; other site
224308008051	substrate binding site [chemical binding]; other site
224308008052	putative catalytic residue [active]
224308008053	glutamate racemase; Region: glut_race; TIGR00067
224308008054	Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427
224308008055	putative binding site; other site
224308008056	putative dimer interface [polypeptide binding]; other site
224308008057	YodA lipocalin-like domain; Region: YodA; pfam09223
224308008058	RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637
224308008059	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308008060	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308008061	DNA binding residues [nucleotide binding]
224308008062	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224308008063	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
224308008064	active site
224308008065	catalytic tetrad [active]
224308008066	citrate transporter, CitMHS family; Region: citMHS; TIGR00784
224308008067	Citrate transporter; Region: CitMHS; pfam03600
224308008068	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308008069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308008070	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308008071	dimerization interface [polypeptide binding]; other site
224308008072	PrpF protein; Region: PrpF; pfam04303
224308008073	Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978
224308008074	chitosan binding site [chemical binding]; other site
224308008075	catalytic residues [active]
224308008076	Mor transcription activator family; Region: Mor; cl02360
224308008077	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308008078	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
224308008079	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
224308008080	Bacterial SH3 domain homologues; Region: SH3b; smart00287
224308008081	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
224308008082	Bacterial SH3 domain homologues; Region: SH3b; smart00287
224308008083	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308008084	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
224308008085	active site
224308008086	metal binding site [ion binding]; metal-binding site
224308008087	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
224308008088	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
224308008089	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
224308008090	NAD binding site [chemical binding]; other site
224308008091	catalytic Zn binding site [ion binding]; other site
224308008092	structural Zn binding site [ion binding]; other site
224308008093	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
224308008094	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224308008095	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
224308008096	DNA binding residues [nucleotide binding]
224308008097	putative dimer interface [polypeptide binding]; other site
224308008098	Evidence 5: No homology to any previously reported sequences
224308008099	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
224308008100	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
224308008101	putative NAD(P) binding site [chemical binding]; other site
224308008102	putative substrate binding site [chemical binding]; other site
224308008103	catalytic Zn binding site [ion binding]; other site
224308008104	structural Zn binding site [ion binding]; other site
224308008105	dimer interface [polypeptide binding]; other site
224308008106	intracellular protease, PfpI family; Region: PfpI; TIGR01382
224308008107	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
224308008108	proposed catalytic triad [active]
224308008109	conserved cys residue [active]
224308008110	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
224308008111	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
224308008112	substrate binding [chemical binding]; other site
224308008113	active site
224308008114	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
224308008115	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
224308008116	PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828
224308008117	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
224308008118	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
224308008119	active site
224308008120	phosphorylation site [posttranslational modification]
224308008121	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
224308008122	active pocket/dimerization site; other site
224308008123	active site
224308008124	phosphorylation site [posttranslational modification]
224308008125	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
224308008126	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308008127	Walker A motif; other site
224308008128	ATP binding site [chemical binding]; other site
224308008129	Walker B motif; other site
224308008130	arginine finger; other site
224308008131	Transcriptional antiterminator [Transcription]; Region: COG3933
224308008132	PRD domain; Region: PRD; pfam00874
224308008133	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
224308008134	active pocket/dimerization site; other site
224308008135	active site
224308008136	phosphorylation site [posttranslational modification]
224308008137	PRD domain; Region: PRD; pfam00874
224308008138	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
224308008139	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
224308008140	Predicted transcriptional regulators [Transcription]; Region: COG1378
224308008141	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
224308008142	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
224308008143	C-terminal domain interface [polypeptide binding]; other site
224308008144	sugar binding site [chemical binding]; other site
224308008145	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
224308008146	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308008147	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308008148	DNA binding residues [nucleotide binding]
224308008149	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
224308008150	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
224308008151	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
224308008152	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
224308008153	catalytic triad [active]
224308008154	catalytic triad [active]
224308008155	oxyanion hole [active]
224308008156	YrhK-like protein; Region: YrhK; pfam14145
224308008157	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
224308008158	Cytochrome P450; Region: p450; pfam00067
224308008159	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
224308008160	Flavodoxin; Region: Flavodoxin_1; pfam00258
224308008161	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
224308008162	FAD binding pocket [chemical binding]; other site
224308008163	FAD binding motif [chemical binding]; other site
224308008164	catalytic residues [active]
224308008165	NAD binding pocket [chemical binding]; other site
224308008166	phosphate binding motif [ion binding]; other site
224308008167	beta-alpha-beta structure motif; other site
224308008168	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308008169	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308008170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308008171	S-adenosylmethionine binding site [chemical binding]; other site
224308008172	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
224308008173	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
224308008174	Uncharacterized conserved protein [Function unknown]; Region: COG5609
224308008175	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
224308008176	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224308008177	catalytic loop [active]
224308008178	iron binding site [ion binding]; other site
224308008179	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
224308008180	4Fe-4S binding domain; Region: Fer4; pfam00037
224308008181	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
224308008182	[4Fe-4S] binding site [ion binding]; other site
224308008183	molybdopterin cofactor binding site; other site
224308008184	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
224308008185	molybdopterin cofactor binding site; other site
224308008186	Uncharacterized conserved protein [Function unknown]; Region: COG2427
224308008187	YrhC-like protein; Region: YrhC; pfam14143
224308008188	cystathionine beta-lyase; Provisional; Region: PRK07671
224308008189	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
224308008190	homodimer interface [polypeptide binding]; other site
224308008191	substrate-cofactor binding pocket; other site
224308008192	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308008193	catalytic residue [active]
224308008194	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
224308008195	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
224308008196	dimer interface [polypeptide binding]; other site
224308008197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308008198	catalytic residue [active]
224308008199	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
224308008200	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
224308008201	Methyltransferase domain; Region: Methyltransf_23; pfam13489
224308008202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308008203	S-adenosylmethionine binding site [chemical binding]; other site
224308008204	Protein of unknown function (DUF2536); Region: DUF2536; pfam10750
224308008205	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
224308008206	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
224308008207	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
224308008208	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224308008209	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
224308008210	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
224308008211	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
224308008212	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
224308008213	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
224308008214	ATP-binding site [chemical binding]; other site
224308008215	Sugar specificity; other site
224308008216	Pyrimidine base specificity; other site
224308008217	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
224308008218	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
224308008219	Peptidase family U32; Region: Peptidase_U32; pfam01136
224308008220	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
224308008221	Peptidase family U32; Region: Peptidase_U32; pfam01136
224308008222	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
224308008223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308008224	S-adenosylmethionine binding site [chemical binding]; other site
224308008225	conserved hypothetical protein, YceG family; Region: TIGR00247
224308008226	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
224308008227	dimerization interface [polypeptide binding]; other site
224308008228	hypothetical protein; Provisional; Region: PRK13678
224308008229	RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250
224308008230	hypothetical protein; Provisional; Region: PRK05473
224308008231	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
224308008232	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
224308008233	motif 1; other site
224308008234	active site
224308008235	motif 2; other site
224308008236	motif 3; other site
224308008237	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
224308008238	DHHA1 domain; Region: DHHA1; pfam02272
224308008239	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
224308008240	Domain of unknown function DUF20; Region: UPF0118; pfam01594
224308008241	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224308008242	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
224308008243	Walker A/P-loop; other site
224308008244	ATP binding site [chemical binding]; other site
224308008245	Q-loop/lid; other site
224308008246	ABC transporter signature motif; other site
224308008247	Walker B; other site
224308008248	D-loop; other site
224308008249	H-loop/switch region; other site
224308008250	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
224308008251	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224308008252	substrate binding pocket [chemical binding]; other site
224308008253	membrane-bound complex binding site; other site
224308008254	hinge residues; other site
224308008255	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
224308008256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308008257	dimer interface [polypeptide binding]; other site
224308008258	conserved gate region; other site
224308008259	putative PBP binding loops; other site
224308008260	ABC-ATPase subunit interface; other site
224308008261	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
224308008262	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308008263	dimer interface [polypeptide binding]; other site
224308008264	ABC-ATPase subunit interface; other site
224308008265	putative PBP binding loops; other site
224308008266	Protein of unknown function (DUF3918); Region: DUF3918; pfam13056
224308008267	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
224308008268	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
224308008269	AAA domain; Region: AAA_30; pfam13604
224308008270	Family description; Region: UvrD_C_2; pfam13538
224308008271	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308008272	TPR motif; other site
224308008273	TPR repeat; Region: TPR_11; pfam13414
224308008274	binding surface
224308008275	TPR repeat; Region: TPR_11; pfam13414
224308008276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308008277	binding surface
224308008278	TPR motif; other site
224308008279	TPR repeat; Region: TPR_11; pfam13414
224308008280	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308008281	binding surface
224308008282	TPR motif; other site
224308008283	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
224308008284	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
224308008285	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
224308008286	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
224308008287	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224308008288	catalytic residue [active]
224308008289	Predicted transcriptional regulator [Transcription]; Region: COG1959
224308008290	Transcriptional regulator; Region: Rrf2; pfam02082
224308008291	recombination factor protein RarA; Reviewed; Region: PRK13342
224308008292	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308008293	Walker A motif; other site
224308008294	ATP binding site [chemical binding]; other site
224308008295	Walker B motif; other site
224308008296	arginine finger; other site
224308008297	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
224308008298	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
224308008299	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
224308008300	putative ATP binding site [chemical binding]; other site
224308008301	putative substrate interface [chemical binding]; other site
224308008302	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
224308008303	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
224308008304	dimer interface [polypeptide binding]; other site
224308008305	anticodon binding site; other site
224308008306	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
224308008307	homodimer interface [polypeptide binding]; other site
224308008308	motif 1; other site
224308008309	active site
224308008310	motif 2; other site
224308008311	GAD domain; Region: GAD; pfam02938
224308008312	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
224308008313	motif 3; other site
224308008314	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
224308008315	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
224308008316	dimer interface [polypeptide binding]; other site
224308008317	motif 1; other site
224308008318	active site
224308008319	motif 2; other site
224308008320	motif 3; other site
224308008321	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
224308008322	anticodon binding site; other site
224308008323	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
224308008324	Bacterial SH3 domain homologues; Region: SH3b; smart00287
224308008325	Bacterial SH3 domain; Region: SH3_3; pfam08239
224308008326	Bacterial SH3 domain; Region: SH3_3; pfam08239
224308008327	Bacterial SH3 domain homologues; Region: SH3b; smart00287
224308008328	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
224308008329	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
224308008330	active site
224308008331	metal binding site [ion binding]; metal-binding site
224308008332	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
224308008333	dimerization interface [polypeptide binding]; other site
224308008334	putative tRNAtyr binding site [nucleotide binding]; other site
224308008335	putative active site [active]
224308008336	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
224308008337	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224308008338	Zn2+ binding site [ion binding]; other site
224308008339	Mg2+ binding site [ion binding]; other site
224308008340	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
224308008341	synthetase active site [active]
224308008342	NTP binding site [chemical binding]; other site
224308008343	metal binding site [ion binding]; metal-binding site
224308008344	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
224308008345	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
224308008346	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308008347	active site
224308008348	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
224308008349	DHH family; Region: DHH; pfam01368
224308008350	DHHA1 domain; Region: DHHA1; pfam02272
224308008351	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
224308008352	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
224308008353	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
224308008354	TrkA-C domain; Region: TrkA_C; pfam02080
224308008355	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
224308008356	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
224308008357	Protein export membrane protein; Region: SecD_SecF; pfam02355
224308008358	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
224308008359	stage V sporulation protein B; Region: spore_V_B; TIGR02900
224308008360	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
224308008361	Predicted membrane protein [Function unknown]; Region: COG2323
224308008362	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
224308008363	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
224308008364	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
224308008365	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
224308008366	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
224308008367	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
224308008368	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
224308008369	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
224308008370	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308008371	Walker A motif; other site
224308008372	ATP binding site [chemical binding]; other site
224308008373	Walker B motif; other site
224308008374	arginine finger; other site
224308008375	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
224308008376	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
224308008377	RuvA N terminal domain; Region: RuvA_N; pfam01330
224308008378	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
224308008379	Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977
224308008380	BofC C-terminal domain; Region: BofC_C; pfam08955
224308008381	polyol permease family; Region: 2A0118; TIGR00897
224308008382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308008383	putative substrate translocation pore; other site
224308008384	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224308008385	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
224308008386	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
224308008387	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
224308008388	active site
224308008389	substrate binding site [chemical binding]; other site
224308008390	ATP binding site [chemical binding]; other site
224308008391	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
224308008392	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
224308008393	hypothetical protein; Validated; Region: PRK00110
224308008394	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
224308008395	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308008396	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
224308008397	quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550
224308008398	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
224308008399	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
224308008400	dimerization interface [polypeptide binding]; other site
224308008401	active site
224308008402	L-aspartate oxidase; Provisional; Region: PRK08071
224308008403	L-aspartate oxidase; Provisional; Region: PRK06175
224308008404	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
224308008405	cysteine desulfurase; Provisional; Region: PRK02948
224308008406	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
224308008407	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224308008408	catalytic residue [active]
224308008409	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
224308008410	HTH domain; Region: HTH_11; pfam08279
224308008411	3H domain; Region: 3H; pfam02829
224308008412	prephenate dehydratase; Provisional; Region: PRK11898
224308008413	Prephenate dehydratase; Region: PDT; pfam00800
224308008414	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
224308008415	putative L-Phe binding site [chemical binding]; other site
224308008416	hypothetical protein; Provisional; Region: PRK04435
224308008417	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
224308008418	GTPase CgtA; Reviewed; Region: obgE; PRK12297
224308008419	GTP1/OBG; Region: GTP1_OBG; pfam01018
224308008420	Obg GTPase; Region: Obg; cd01898
224308008421	G1 box; other site
224308008422	GTP/Mg2+ binding site [chemical binding]; other site
224308008423	Switch I region; other site
224308008424	G2 box; other site
224308008425	G3 box; other site
224308008426	Switch II region; other site
224308008427	G4 box; other site
224308008428	G5 box; other site
224308008429	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
224308008430	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
224308008431	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
224308008432	hypothetical protein; Provisional; Region: PRK14553
224308008433	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
224308008434	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
224308008435	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
224308008436	active site
224308008437	Peptidase family M50; Region: Peptidase_M50; pfam02163
224308008438	putative substrate binding region [chemical binding]; other site
224308008439	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
224308008440	Peptidase family M23; Region: Peptidase_M23; pfam01551
224308008441	septum site-determining protein MinD; Region: minD_bact; TIGR01968
224308008442	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
224308008443	Switch I; other site
224308008444	Switch II; other site
224308008445	septum formation inhibitor; Reviewed; Region: minC; PRK00513
224308008446	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
224308008447	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
224308008448	rod shape-determining protein MreC; Region: mreC; TIGR00219
224308008449	rod shape-determining protein MreC; Region: MreC; pfam04085
224308008450	rod shape-determining protein MreB; Provisional; Region: PRK13927
224308008451	MreB and similar proteins; Region: MreB_like; cd10225
224308008452	nucleotide binding site [chemical binding]; other site
224308008453	Mg binding site [ion binding]; other site
224308008454	putative protofilament interaction site [polypeptide binding]; other site
224308008455	RodZ interaction site [polypeptide binding]; other site
224308008456	hypothetical protein; Reviewed; Region: PRK00024
224308008457	Helix-hairpin-helix motif; Region: HHH; pfam00633
224308008458	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
224308008459	MPN+ (JAMM) motif; other site
224308008460	Zinc-binding site [ion binding]; other site
224308008461	Maf-like protein; Region: Maf; pfam02545
224308008462	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
224308008463	active site
224308008464	dimer interface [polypeptide binding]; other site
224308008465	Sporulation related domain; Region: SPOR; pfam05036
224308008466	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
224308008467	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
224308008468	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
224308008469	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
224308008470	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224308008471	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224308008472	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
224308008473	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224308008474	active site
224308008475	HIGH motif; other site
224308008476	nucleotide binding site [chemical binding]; other site
224308008477	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
224308008478	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
224308008479	active site
224308008480	KMSKS motif; other site
224308008481	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
224308008482	tRNA binding surface [nucleotide binding]; other site
224308008483	anticodon binding site; other site
224308008484	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
224308008485	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
224308008486	stage VI sporulation protein D; Region: spore_VI_D; TIGR02907
224308008487	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224308008488	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
224308008489	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224308008490	inhibitor-cofactor binding pocket; inhibition site
224308008491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308008492	catalytic residue [active]
224308008493	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
224308008494	dimer interface [polypeptide binding]; other site
224308008495	active site
224308008496	Schiff base residues; other site
224308008497	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
224308008498	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
224308008499	active site
224308008500	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
224308008501	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
224308008502	domain interfaces; other site
224308008503	active site
224308008504	Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578
224308008505	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
224308008506	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
224308008507	tRNA; other site
224308008508	putative tRNA binding site [nucleotide binding]; other site
224308008509	putative NADP binding site [chemical binding]; other site
224308008510	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
224308008511	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
224308008512	G1 box; other site
224308008513	GTP/Mg2+ binding site [chemical binding]; other site
224308008514	Switch I region; other site
224308008515	G2 box; other site
224308008516	G3 box; other site
224308008517	Switch II region; other site
224308008518	G4 box; other site
224308008519	G5 box; other site
224308008520	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
224308008521	Found in ATP-dependent protease La (LON); Region: LON; smart00464
224308008522	Found in ATP-dependent protease La (LON); Region: LON; smart00464
224308008523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308008524	Walker A motif; other site
224308008525	ATP binding site [chemical binding]; other site
224308008526	Walker B motif; other site
224308008527	arginine finger; other site
224308008528	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
224308008529	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
224308008530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308008531	Walker A motif; other site
224308008532	ATP binding site [chemical binding]; other site
224308008533	Walker B motif; other site
224308008534	arginine finger; other site
224308008535	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
224308008536	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
224308008537	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
224308008538	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308008539	Walker A motif; other site
224308008540	ATP binding site [chemical binding]; other site
224308008541	Walker B motif; other site
224308008542	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
224308008543	trigger factor; Provisional; Region: tig; PRK01490
224308008544	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
224308008545	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
224308008546	TPR repeat; Region: TPR_11; pfam13414
224308008547	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308008548	binding surface
224308008549	TPR motif; other site
224308008550	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
224308008551	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
224308008552	substrate binding site [chemical binding]; other site
224308008553	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
224308008554	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
224308008555	substrate binding site [chemical binding]; other site
224308008556	ligand binding site [chemical binding]; other site
224308008557	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
224308008558	tartrate dehydrogenase; Region: TTC; TIGR02089
224308008559	2-isopropylmalate synthase; Validated; Region: PRK00915
224308008560	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
224308008561	active site
224308008562	catalytic residues [active]
224308008563	metal binding site [ion binding]; metal-binding site
224308008564	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
224308008565	ketol-acid reductoisomerase; Provisional; Region: PRK05479
224308008566	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
224308008567	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
224308008568	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
224308008569	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
224308008570	putative valine binding site [chemical binding]; other site
224308008571	dimer interface [polypeptide binding]; other site
224308008572	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
224308008573	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
224308008574	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
224308008575	PYR/PP interface [polypeptide binding]; other site
224308008576	dimer interface [polypeptide binding]; other site
224308008577	TPP binding site [chemical binding]; other site
224308008578	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
224308008579	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
224308008580	TPP-binding site [chemical binding]; other site
224308008581	dimer interface [polypeptide binding]; other site
224308008582	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
224308008583	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308008584	Coenzyme A binding pocket [chemical binding]; other site
224308008585	Heat induced stress protein YflT; Region: YflT; pfam11181
224308008586	conserved domain; Region: TIGR02271
224308008587	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
224308008588	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224308008589	active site
224308008590	metal binding site [ion binding]; metal-binding site
224308008591	homotetramer interface [polypeptide binding]; other site
224308008592	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
224308008593	active site
224308008594	dimerization interface [polypeptide binding]; other site
224308008595	ribonuclease PH; Reviewed; Region: rph; PRK00173
224308008596	Ribonuclease PH; Region: RNase_PH_bact; cd11362
224308008597	hexamer interface [polypeptide binding]; other site
224308008598	active site
224308008599	Spore germination protein [General function prediction only]; Region: COG5401
224308008600	Sporulation and spore germination; Region: Germane; pfam10646
224308008601	Sporulation and spore germination; Region: Germane; pfam10646
224308008602	glutamate racemase; Region: glut_race; TIGR00067
224308008603	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308008604	MarR family; Region: MarR; pfam01047
224308008605	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308008606	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308008607	DNA binding residues [nucleotide binding]
224308008608	dimerization interface [polypeptide binding]; other site
224308008609	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
224308008610	active site
224308008611	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
224308008612	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
224308008613	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
224308008614	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
224308008615	L-aspartate oxidase; Provisional; Region: PRK06175
224308008616	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
224308008617	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
224308008618	putative Iron-sulfur protein interface [polypeptide binding]; other site
224308008619	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
224308008620	proximal heme binding site [chemical binding]; other site
224308008621	distal heme binding site [chemical binding]; other site
224308008622	putative dimer interface [polypeptide binding]; other site
224308008623	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
224308008624	aspartate kinase; Reviewed; Region: PRK06635
224308008625	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
224308008626	putative nucleotide binding site [chemical binding]; other site
224308008627	putative catalytic residues [active]
224308008628	putative Mg ion binding site [ion binding]; other site
224308008629	putative aspartate binding site [chemical binding]; other site
224308008630	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
224308008631	putative allosteric regulatory site; other site
224308008632	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
224308008633	putative allosteric regulatory residue; other site
224308008634	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
224308008635	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
224308008636	GIY-YIG motif/motif A; other site
224308008637	active site
224308008638	catalytic site [active]
224308008639	putative DNA binding site [nucleotide binding]; other site
224308008640	metal binding site [ion binding]; metal-binding site
224308008641	UvrB/uvrC motif; Region: UVR; pfam02151
224308008642	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
224308008643	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224308008644	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
224308008645	catalytic residues [active]
224308008646	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
224308008647	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
224308008648	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
224308008649	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
224308008650	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
224308008651	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
224308008652	Ligand binding site [chemical binding]; other site
224308008653	Electron transfer flavoprotein domain; Region: ETF; pfam01012
224308008654	enoyl-CoA hydratase; Provisional; Region: PRK07658
224308008655	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224308008656	substrate binding site [chemical binding]; other site
224308008657	oxyanion hole (OAH) forming residues; other site
224308008658	trimer interface [polypeptide binding]; other site
224308008659	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308008660	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308008661	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
224308008662	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
224308008663	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
224308008664	acyl-activating enzyme (AAE) consensus motif; other site
224308008665	putative AMP binding site [chemical binding]; other site
224308008666	putative active site [active]
224308008667	putative CoA binding site [chemical binding]; other site
224308008668	Predicted membrane protein [Function unknown]; Region: COG3766
224308008669	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
224308008670	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
224308008671	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
224308008672	MutS domain III; Region: MutS_III; pfam05192
224308008673	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
224308008674	Walker A/P-loop; other site
224308008675	ATP binding site [chemical binding]; other site
224308008676	Q-loop/lid; other site
224308008677	ABC transporter signature motif; other site
224308008678	Walker B; other site
224308008679	D-loop; other site
224308008680	H-loop/switch region; other site
224308008681	Smr domain; Region: Smr; pfam01713
224308008682	hypothetical protein; Provisional; Region: PRK08609
224308008683	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
224308008684	active site
224308008685	primer binding site [nucleotide binding]; other site
224308008686	NTP  binding site [chemical binding]; other site
224308008687	metal binding triad [ion binding]; metal-binding site
224308008688	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
224308008689	active site
224308008690	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
224308008691	Colicin V production protein; Region: Colicin_V; pfam02674
224308008692	cell division protein ZapA; Provisional; Region: PRK14126
224308008693	ribonuclease HIII; Provisional; Region: PRK00996
224308008694	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
224308008695	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
224308008696	RNA/DNA hybrid binding site [nucleotide binding]; other site
224308008697	active site
224308008698	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
224308008699	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
224308008700	putative tRNA-binding site [nucleotide binding]; other site
224308008701	B3/4 domain; Region: B3_4; pfam03483
224308008702	tRNA synthetase B5 domain; Region: B5; smart00874
224308008703	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
224308008704	dimer interface [polypeptide binding]; other site
224308008705	motif 1; other site
224308008706	motif 3; other site
224308008707	motif 2; other site
224308008708	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
224308008709	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
224308008710	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
224308008711	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
224308008712	dimer interface [polypeptide binding]; other site
224308008713	motif 1; other site
224308008714	active site
224308008715	motif 2; other site
224308008716	motif 3; other site
224308008717	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
224308008718	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
224308008719	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
224308008720	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
224308008721	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
224308008722	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
224308008723	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
224308008724	FAD binding domain; Region: FAD_binding_4; pfam01565
224308008725	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
224308008726	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
224308008727	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
224308008728	Cysteine-rich domain; Region: CCG; pfam02754
224308008729	Cysteine-rich domain; Region: CCG; pfam02754
224308008730	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
224308008731	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308008732	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
224308008733	Carbon starvation protein CstA; Region: CstA; pfam02554
224308008734	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
224308008735	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
224308008736	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
224308008737	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224308008738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308008739	putative PBP binding loops; other site
224308008740	dimer interface [polypeptide binding]; other site
224308008741	ABC-ATPase subunit interface; other site
224308008742	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
224308008743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308008744	dimer interface [polypeptide binding]; other site
224308008745	conserved gate region; other site
224308008746	putative PBP binding loops; other site
224308008747	ABC-ATPase subunit interface; other site
224308008748	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224308008749	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
224308008750	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
224308008751	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
224308008752	active site
224308008753	metal binding site [ion binding]; metal-binding site
224308008754	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
224308008755	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308008756	active site
224308008757	motif I; other site
224308008758	motif II; other site
224308008759	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308008760	motif II; other site
224308008761	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
224308008762	L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760
224308008763	intersubunit interface [polypeptide binding]; other site
224308008764	active site
224308008765	Zn2+ binding site [ion binding]; other site
224308008766	L-ribulokinase; Region: L-ribulokinase; TIGR01234
224308008767	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
224308008768	N- and C-terminal domain interface [polypeptide binding]; other site
224308008769	active site
224308008770	MgATP binding site [chemical binding]; other site
224308008771	catalytic site [active]
224308008772	metal binding site [ion binding]; metal-binding site
224308008773	carbohydrate binding site [chemical binding]; other site
224308008774	homodimer interface [polypeptide binding]; other site
224308008775	L-arabinose isomerase; Provisional; Region: PRK02929
224308008776	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
224308008777	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
224308008778	trimer interface [polypeptide binding]; other site
224308008779	putative substrate binding site [chemical binding]; other site
224308008780	putative metal binding site [ion binding]; other site
224308008781	Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988
224308008782	substrate binding site [chemical binding]; other site
224308008783	active site
224308008784	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
224308008785	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
224308008786	oligomer interface [polypeptide binding]; other site
224308008787	active site
224308008788	metal binding site [ion binding]; metal-binding site
224308008789	Predicted membrane protein [Function unknown]; Region: COG3326
224308008790	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
224308008791	23S rRNA binding site [nucleotide binding]; other site
224308008792	L21 binding site [polypeptide binding]; other site
224308008793	L13 binding site [polypeptide binding]; other site
224308008794	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
224308008795	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
224308008796	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
224308008797	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
224308008798	antiholin-like protein LrgB; Provisional; Region: PRK04288
224308008799	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
224308008800	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
224308008801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308008802	active site
224308008803	phosphorylation site [posttranslational modification]
224308008804	intermolecular recognition site; other site
224308008805	dimerization interface [polypeptide binding]; other site
224308008806	LytTr DNA-binding domain; Region: LytTR; pfam04397
224308008807	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
224308008808	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
224308008809	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
224308008810	Histidine kinase; Region: His_kinase; pfam06580
224308008811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308008812	ATP binding site [chemical binding]; other site
224308008813	Mg2+ binding site [ion binding]; other site
224308008814	G-X-G motif; other site
224308008815	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
224308008816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308008817	motif II; other site
224308008818	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
224308008819	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
224308008820	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
224308008821	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
224308008822	active site
224308008823	dimer interface [polypeptide binding]; other site
224308008824	motif 1; other site
224308008825	motif 2; other site
224308008826	motif 3; other site
224308008827	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
224308008828	anticodon binding site; other site
224308008829	putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834
224308008830	Uncharacterized conserved protein [Function unknown]; Region: COG0398
224308008831	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
224308008832	primosomal protein DnaI; Reviewed; Region: PRK08939
224308008833	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
224308008834	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308008835	Walker A motif; other site
224308008836	ATP binding site [chemical binding]; other site
224308008837	Walker B motif; other site
224308008838	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
224308008839	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
224308008840	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
224308008841	ATP cone domain; Region: ATP-cone; pfam03477
224308008842	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
224308008843	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
224308008844	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
224308008845	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
224308008846	Predicted transcriptional regulators [Transcription]; Region: COG1733
224308008847	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
224308008848	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224308008849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308008850	putative substrate translocation pore; other site
224308008851	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224308008852	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
224308008853	active site
224308008854	catalytic tetrad [active]
224308008855	dephospho-CoA kinase; Region: TIGR00152
224308008856	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
224308008857	CoA-binding site [chemical binding]; other site
224308008858	ATP-binding [chemical binding]; other site
224308008859	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
224308008860	Domain of unknown function DUF; Region: DUF204; pfam02659
224308008861	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
224308008862	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
224308008863	DNA binding site [nucleotide binding]
224308008864	catalytic residue [active]
224308008865	H2TH interface [polypeptide binding]; other site
224308008866	putative catalytic residues [active]
224308008867	turnover-facilitating residue; other site
224308008868	intercalation triad [nucleotide binding]; other site
224308008869	8OG recognition residue [nucleotide binding]; other site
224308008870	putative reading head residues; other site
224308008871	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
224308008872	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
224308008873	DNA polymerase I; Provisional; Region: PRK05755
224308008874	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
224308008875	active site
224308008876	metal binding site 1 [ion binding]; metal-binding site
224308008877	putative 5' ssDNA interaction site; other site
224308008878	metal binding site 3; metal-binding site
224308008879	metal binding site 2 [ion binding]; metal-binding site
224308008880	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
224308008881	putative DNA binding site [nucleotide binding]; other site
224308008882	putative metal binding site [ion binding]; other site
224308008883	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
224308008884	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
224308008885	active site
224308008886	DNA binding site [nucleotide binding]
224308008887	catalytic site [active]
224308008888	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
224308008889	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308008890	putative active site [active]
224308008891	heme pocket [chemical binding]; other site
224308008892	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308008893	dimer interface [polypeptide binding]; other site
224308008894	phosphorylation site [posttranslational modification]
224308008895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308008896	ATP binding site [chemical binding]; other site
224308008897	Mg2+ binding site [ion binding]; other site
224308008898	G-X-G motif; other site
224308008899	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308008900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308008901	active site
224308008902	phosphorylation site [posttranslational modification]
224308008903	intermolecular recognition site; other site
224308008904	dimerization interface [polypeptide binding]; other site
224308008905	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308008906	DNA binding site [nucleotide binding]
224308008907	malate dehydrogenase; Reviewed; Region: PRK06223
224308008908	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
224308008909	NAD(P) binding site [chemical binding]; other site
224308008910	dimer interface [polypeptide binding]; other site
224308008911	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224308008912	substrate binding site [chemical binding]; other site
224308008913	isocitrate dehydrogenase; Reviewed; Region: PRK07006
224308008914	isocitrate dehydrogenase; Validated; Region: PRK07362
224308008915	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
224308008916	dimer interface [polypeptide binding]; other site
224308008917	Citrate synthase; Region: Citrate_synt; pfam00285
224308008918	active site
224308008919	citrylCoA binding site [chemical binding]; other site
224308008920	oxalacetate/citrate binding site [chemical binding]; other site
224308008921	coenzyme A binding site [chemical binding]; other site
224308008922	catalytic triad [active]
224308008923	Predicted membrane protein [Function unknown]; Region: COG2707
224308008924	sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872
224308008925	Domain of unknown function DUF20; Region: UPF0118; pfam01594
224308008926	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
224308008927	pyruvate kinase; Provisional; Region: PRK06354
224308008928	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
224308008929	domain interfaces; other site
224308008930	active site
224308008931	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
224308008932	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
224308008933	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
224308008934	active site
224308008935	ADP/pyrophosphate binding site [chemical binding]; other site
224308008936	dimerization interface [polypeptide binding]; other site
224308008937	allosteric effector site; other site
224308008938	fructose-1,6-bisphosphate binding site; other site
224308008939	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
224308008940	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
224308008941	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
224308008942	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
224308008943	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
224308008944	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
224308008945	Malic enzyme, N-terminal domain; Region: malic; pfam00390
224308008946	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
224308008947	putative NAD(P) binding site [chemical binding]; other site
224308008948	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920
224308008949	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
224308008950	active site
224308008951	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
224308008952	generic binding surface I; other site
224308008953	generic binding surface II; other site
224308008954	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
224308008955	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
224308008956	DHH family; Region: DHH; pfam01368
224308008957	DHHA1 domain; Region: DHHA1; pfam02272
224308008958	YtpI-like protein; Region: YtpI; pfam14007
224308008959	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
224308008960	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308008961	DNA-binding site [nucleotide binding]; DNA binding site
224308008962	DRTGG domain; Region: DRTGG; pfam07085
224308008963	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
224308008964	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
224308008965	active site 2 [active]
224308008966	active site 1 [active]
224308008967	Predicted permeases [General function prediction only]; Region: COG0730
224308008968	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
224308008969	amidohydrolase; Region: amidohydrolases; TIGR01891
224308008970	metal binding site [ion binding]; metal-binding site
224308008971	dimer interface [polypeptide binding]; other site
224308008972	Riboflavin kinase; Region: Flavokinase; pfam01687
224308008973	Riboflavin kinase; Region: Flavokinase; smart00904
224308008974	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
224308008975	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
224308008976	active site
224308008977	non-prolyl cis peptide bond; other site
224308008978	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
224308008979	catalytic residues [active]
224308008980	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
224308008981	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
224308008982	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
224308008983	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224308008984	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
224308008985	Walker A/P-loop; other site
224308008986	ATP binding site [chemical binding]; other site
224308008987	Q-loop/lid; other site
224308008988	ABC transporter signature motif; other site
224308008989	Walker B; other site
224308008990	D-loop; other site
224308008991	H-loop/switch region; other site
224308008992	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308008993	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
224308008994	dimer interface [polypeptide binding]; other site
224308008995	conserved gate region; other site
224308008996	putative PBP binding loops; other site
224308008997	ABC-ATPase subunit interface; other site
224308008998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308008999	dimer interface [polypeptide binding]; other site
224308009000	conserved gate region; other site
224308009001	putative PBP binding loops; other site
224308009002	ABC-ATPase subunit interface; other site
224308009003	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
224308009004	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224308009005	substrate binding pocket [chemical binding]; other site
224308009006	membrane-bound complex binding site; other site
224308009007	hinge residues; other site
224308009008	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
224308009009	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224308009010	substrate binding pocket [chemical binding]; other site
224308009011	membrane-bound complex binding site; other site
224308009012	hinge residues; other site
224308009013	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
224308009014	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308009015	Coenzyme A binding pocket [chemical binding]; other site
224308009016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308009017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308009018	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308009019	dimerization interface [polypeptide binding]; other site
224308009020	metal-dependent hydrolase; Provisional; Region: PRK00685
224308009021	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
224308009022	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
224308009023	classical (c) SDRs; Region: SDR_c; cd05233
224308009024	NAD(P) binding site [chemical binding]; other site
224308009025	active site
224308009026	argininosuccinate lyase; Provisional; Region: PRK00855
224308009027	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
224308009028	active sites [active]
224308009029	tetramer interface [polypeptide binding]; other site
224308009030	argininosuccinate synthase; Provisional; Region: PRK13820
224308009031	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
224308009032	ANP binding site [chemical binding]; other site
224308009033	Substrate Binding Site II [chemical binding]; other site
224308009034	Substrate Binding Site I [chemical binding]; other site
224308009035	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
224308009036	MPT binding site; other site
224308009037	trimer interface [polypeptide binding]; other site
224308009038	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
224308009039	propionate/acetate kinase; Provisional; Region: PRK12379
224308009040	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
224308009041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308009042	S-adenosylmethionine binding site [chemical binding]; other site
224308009043	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
224308009044	dimer interface [polypeptide binding]; other site
224308009045	catalytic triad [active]
224308009046	peroxidatic and resolving cysteines [active]
224308009047	sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874
224308009048	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
224308009049	Predicted membrane protein/domain [Function unknown]; Region: COG1714
224308009050	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
224308009051	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
224308009052	tandem repeat interface [polypeptide binding]; other site
224308009053	oligomer interface [polypeptide binding]; other site
224308009054	active site residues [active]
224308009055	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
224308009056	ATP-NAD kinase; Region: NAD_kinase; pfam01513
224308009057	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
224308009058	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
224308009059	active site
224308009060	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
224308009061	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
224308009062	active site
224308009063	acyl-activating enzyme (AAE) consensus motif; other site
224308009064	putative CoA binding site [chemical binding]; other site
224308009065	AMP binding site [chemical binding]; other site
224308009066	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
224308009067	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
224308009068	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
224308009069	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
224308009070	Ligand Binding Site [chemical binding]; other site
224308009071	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
224308009072	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
224308009073	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224308009074	catalytic residue [active]
224308009075	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
224308009076	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
224308009077	histidinol-phosphatase; Reviewed; Region: PRK08123
224308009078	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
224308009079	active site
224308009080	dimer interface [polypeptide binding]; other site
224308009081	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308009082	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308009083	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
224308009084	GAF domain; Region: GAF_2; pfam13185
224308009085	GAF domain; Region: GAF; cl17456
224308009086	GAF domain; Region: GAF_3; pfam13492
224308009087	GAF domain; Region: GAF_2; pfam13185
224308009088	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
224308009089	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224308009090	metal binding site [ion binding]; metal-binding site
224308009091	active site
224308009092	I-site; other site
224308009093	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
224308009094	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
224308009095	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308009096	RNA binding surface [nucleotide binding]; other site
224308009097	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
224308009098	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
224308009099	active site
224308009100	HIGH motif; other site
224308009101	dimer interface [polypeptide binding]; other site
224308009102	KMSKS motif; other site
224308009103	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308009104	RNA binding surface [nucleotide binding]; other site
224308009105	acetyl-CoA synthetase; Provisional; Region: PRK04319
224308009106	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
224308009107	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
224308009108	active site
224308009109	acyl-activating enzyme (AAE) consensus motif; other site
224308009110	putative CoA binding site [chemical binding]; other site
224308009111	AMP binding site [chemical binding]; other site
224308009112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308009113	Coenzyme A binding pocket [chemical binding]; other site
224308009114	FOG: CBS domain [General function prediction only]; Region: COG0517
224308009115	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
224308009116	C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883
224308009117	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
224308009118	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
224308009119	active site
224308009120	Zn binding site [ion binding]; other site
224308009121	flagellar motor protein MotS; Reviewed; Region: PRK06925
224308009122	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224308009123	ligand binding site [chemical binding]; other site
224308009124	flagellar motor protein MotP; Reviewed; Region: PRK06926
224308009125	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
224308009126	catabolite control protein A; Region: ccpA; TIGR01481
224308009127	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308009128	DNA binding site [nucleotide binding]
224308009129	domain linker motif; other site
224308009130	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
224308009131	dimerization interface [polypeptide binding]; other site
224308009132	effector binding site; other site
224308009133	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
224308009134	chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801
224308009135	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
224308009136	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
224308009137	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
224308009138	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
224308009139	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
224308009140	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224308009141	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224308009142	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224308009143	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
224308009144	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
224308009145	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
224308009146	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
224308009147	putative tRNA-binding site [nucleotide binding]; other site
224308009148	hypothetical protein; Provisional; Region: PRK13668
224308009149	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224308009150	catalytic residues [active]
224308009151	YtoQ family protein; Region: YtoQ_fam; TIGR03646
224308009152	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
224308009153	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
224308009154	oligomer interface [polypeptide binding]; other site
224308009155	active site
224308009156	metal binding site [ion binding]; metal-binding site
224308009157	Predicted small secreted protein [Function unknown]; Region: COG5584
224308009158	malate dehydrogenase; Provisional; Region: PRK13529
224308009159	Malic enzyme, N-terminal domain; Region: malic; pfam00390
224308009160	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
224308009161	NAD(P) binding site [chemical binding]; other site
224308009162	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224308009163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308009164	S-adenosylmethionine binding site [chemical binding]; other site
224308009165	YtzH-like protein; Region: YtzH; pfam14165
224308009166	Phosphotransferase enzyme family; Region: APH; pfam01636
224308009167	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
224308009168	substrate binding site [chemical binding]; other site
224308009169	pullulanase, type I; Region: pulA_typeI; TIGR02104
224308009170	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
224308009171	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
224308009172	Ca binding site [ion binding]; other site
224308009173	active site
224308009174	catalytic site [active]
224308009175	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
224308009176	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
224308009177	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
224308009178	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
224308009179	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
224308009180	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
224308009181	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
224308009182	dimer interface [polypeptide binding]; other site
224308009183	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308009184	catalytic residue [active]
224308009185	dipeptidase PepV; Reviewed; Region: PRK07318
224308009186	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
224308009187	active site
224308009188	metal binding site [ion binding]; metal-binding site
224308009189	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
224308009190	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
224308009191	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
224308009192	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
224308009193	Walker A/P-loop; other site
224308009194	ATP binding site [chemical binding]; other site
224308009195	Q-loop/lid; other site
224308009196	ABC transporter signature motif; other site
224308009197	Walker B; other site
224308009198	D-loop; other site
224308009199	H-loop/switch region; other site
224308009200	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224308009201	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
224308009202	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
224308009203	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308009204	RNA binding surface [nucleotide binding]; other site
224308009205	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
224308009206	active site
224308009207	uracil binding [chemical binding]; other site
224308009208	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
224308009209	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
224308009210	Predicted flavoproteins [General function prediction only]; Region: COG2081
224308009211	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
224308009212	BCCT family transporter; Region: BCCT; pfam02028
224308009213	Protein of unknown function (DUF2758); Region: DUF2758; pfam10957
224308009214	Predicted integral membrane protein [Function unknown]; Region: COG5578
224308009215	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224308009216	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
224308009217	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
224308009218	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
224308009219	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
224308009220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308009221	dimer interface [polypeptide binding]; other site
224308009222	conserved gate region; other site
224308009223	ABC-ATPase subunit interface; other site
224308009224	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
224308009225	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308009226	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
224308009227	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
224308009228	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224308009229	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224308009230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308009231	dimer interface [polypeptide binding]; other site
224308009232	conserved gate region; other site
224308009233	putative PBP binding loops; other site
224308009234	ABC-ATPase subunit interface; other site
224308009235	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
224308009236	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224308009237	NAD(P) binding site [chemical binding]; other site
224308009238	active site
224308009239	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
224308009240	Cytochrome P450; Region: p450; cl12078
224308009241	biotin synthase; Validated; Region: PRK06256
224308009242	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308009243	FeS/SAM binding site; other site
224308009244	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
224308009245	AAA domain; Region: AAA_26; pfam13500
224308009246	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
224308009247	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
224308009248	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
224308009249	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
224308009250	substrate-cofactor binding pocket; other site
224308009251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308009252	catalytic residue [active]
224308009253	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
224308009254	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224308009255	inhibitor-cofactor binding pocket; inhibition site
224308009256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308009257	catalytic residue [active]
224308009258	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
224308009259	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
224308009260	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
224308009261	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308009262	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308009263	DNA binding site [nucleotide binding]
224308009264	domain linker motif; other site
224308009265	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
224308009266	putative ligand binding site [chemical binding]; other site
224308009267	putative dimerization interface [polypeptide binding]; other site
224308009268	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
224308009269	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
224308009270	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
224308009271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308009272	dimer interface [polypeptide binding]; other site
224308009273	conserved gate region; other site
224308009274	putative PBP binding loops; other site
224308009275	ABC-ATPase subunit interface; other site
224308009276	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224308009277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308009278	dimer interface [polypeptide binding]; other site
224308009279	conserved gate region; other site
224308009280	putative PBP binding loops; other site
224308009281	ABC-ATPase subunit interface; other site
224308009282	alpha-galactosidase; Provisional; Region: PRK15076
224308009283	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
224308009284	NAD binding site [chemical binding]; other site
224308009285	sugar binding site [chemical binding]; other site
224308009286	divalent metal binding site [ion binding]; other site
224308009287	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
224308009288	dimer interface [polypeptide binding]; other site
224308009289	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
224308009290	active site residue [active]
224308009291	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
224308009292	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
224308009293	HIGH motif; other site
224308009294	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
224308009295	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224308009296	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
224308009297	active site
224308009298	KMSKS motif; other site
224308009299	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
224308009300	tRNA binding surface [nucleotide binding]; other site
224308009301	Protein of unknown function (DUF4257); Region: DUF4257; pfam14074
224308009302	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308009303	PAS domain; Region: PAS_9; pfam13426
224308009304	putative active site [active]
224308009305	heme pocket [chemical binding]; other site
224308009306	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
224308009307	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308009308	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308009309	putative substrate translocation pore; other site
224308009310	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
224308009311	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
224308009312	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
224308009313	FtsX-like permease family; Region: FtsX; pfam02687
224308009314	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
224308009315	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224308009316	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
224308009317	Walker A/P-loop; other site
224308009318	ATP binding site [chemical binding]; other site
224308009319	Q-loop/lid; other site
224308009320	ABC transporter signature motif; other site
224308009321	Walker B; other site
224308009322	D-loop; other site
224308009323	H-loop/switch region; other site
224308009324	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308009325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308009326	ATP binding site [chemical binding]; other site
224308009327	Mg2+ binding site [ion binding]; other site
224308009328	G-X-G motif; other site
224308009329	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308009330	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308009331	active site
224308009332	phosphorylation site [posttranslational modification]
224308009333	intermolecular recognition site; other site
224308009334	dimerization interface [polypeptide binding]; other site
224308009335	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308009336	DNA binding site [nucleotide binding]
224308009337	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
224308009338	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
224308009339	FtsX-like permease family; Region: FtsX; pfam02687
224308009340	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224308009341	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
224308009342	Walker A/P-loop; other site
224308009343	ATP binding site [chemical binding]; other site
224308009344	Q-loop/lid; other site
224308009345	ABC transporter signature motif; other site
224308009346	Walker B; other site
224308009347	D-loop; other site
224308009348	H-loop/switch region; other site
224308009349	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
224308009350	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
224308009351	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
224308009352	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
224308009353	Walker A/P-loop; other site
224308009354	ATP binding site [chemical binding]; other site
224308009355	Q-loop/lid; other site
224308009356	ABC transporter signature motif; other site
224308009357	Walker B; other site
224308009358	D-loop; other site
224308009359	H-loop/switch region; other site
224308009360	Predicted transcriptional regulators [Transcription]; Region: COG1725
224308009361	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308009362	DNA-binding site [nucleotide binding]; DNA binding site
224308009363	Protein of unknown function (DUF2524); Region: DUF2524; pfam10732
224308009364	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
224308009365	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
224308009366	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
224308009367	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
224308009368	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
224308009369	PGAP1-like protein; Region: PGAP1; pfam07819
224308009370	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
224308009371	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
224308009372	trimer interface [polypeptide binding]; other site
224308009373	putative metal binding site [ion binding]; other site
224308009374	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
224308009375	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
224308009376	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
224308009377	active site
224308009378	dimer interface [polypeptide binding]; other site
224308009379	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
224308009380	Ligand Binding Site [chemical binding]; other site
224308009381	Molecular Tunnel; other site
224308009382	S-adenosylmethionine synthetase; Validated; Region: PRK05250
224308009383	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
224308009384	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
224308009385	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
224308009386	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
224308009387	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
224308009388	active site
224308009389	substrate-binding site [chemical binding]; other site
224308009390	metal-binding site [ion binding]
224308009391	ATP binding site [chemical binding]; other site
224308009392	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
224308009393	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
224308009394	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
224308009395	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
224308009396	NMT1-like family; Region: NMT1_2; pfam13379
224308009397	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
224308009398	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
224308009399	Walker A/P-loop; other site
224308009400	ATP binding site [chemical binding]; other site
224308009401	Q-loop/lid; other site
224308009402	ABC transporter signature motif; other site
224308009403	Walker B; other site
224308009404	D-loop; other site
224308009405	H-loop/switch region; other site
224308009406	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
224308009407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308009408	dimer interface [polypeptide binding]; other site
224308009409	conserved gate region; other site
224308009410	putative PBP binding loops; other site
224308009411	ABC-ATPase subunit interface; other site
224308009412	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
224308009413	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
224308009414	nudix motif; other site
224308009415	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
224308009416	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
224308009417	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
224308009418	dimerization interface [polypeptide binding]; other site
224308009419	DPS ferroxidase diiron center [ion binding]; other site
224308009420	ion pore; other site
224308009421	YtkA-like; Region: YtkA; pfam13115
224308009422	S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664
224308009423	Haemolytic domain; Region: Haemolytic; pfam01809
224308009424	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
224308009425	active site clefts [active]
224308009426	zinc binding site [ion binding]; other site
224308009427	dimer interface [polypeptide binding]; other site
224308009428	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
224308009429	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
224308009430	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
224308009431	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
224308009432	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
224308009433	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308009434	ABC-ATPase subunit  interface; other site
224308009435	dimer interface [polypeptide binding]; other site
224308009436	putative PBP binding regions; other site
224308009437	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
224308009438	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308009439	ABC-ATPase subunit  interface; other site
224308009440	dimer interface [polypeptide binding]; other site
224308009441	putative PBP binding regions; other site
224308009442	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
224308009443	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
224308009444	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
224308009445	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
224308009446	Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species.  The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016
224308009447	metal binding site [ion binding]; metal-binding site
224308009448	intersubunit interface [polypeptide binding]; other site
224308009449	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
224308009450	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
224308009451	active site
224308009452	octamer interface [polypeptide binding]; other site
224308009453	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
224308009454	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
224308009455	acyl-activating enzyme (AAE) consensus motif; other site
224308009456	putative AMP binding site [chemical binding]; other site
224308009457	putative active site [active]
224308009458	putative CoA binding site [chemical binding]; other site
224308009459	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224308009460	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
224308009461	substrate binding site [chemical binding]; other site
224308009462	oxyanion hole (OAH) forming residues; other site
224308009463	trimer interface [polypeptide binding]; other site
224308009464	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
224308009465	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
224308009466	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
224308009467	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
224308009468	dimer interface [polypeptide binding]; other site
224308009469	tetramer interface [polypeptide binding]; other site
224308009470	PYR/PP interface [polypeptide binding]; other site
224308009471	TPP binding site [chemical binding]; other site
224308009472	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
224308009473	TPP-binding site; other site
224308009474	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
224308009475	chorismate binding enzyme; Region: Chorismate_bind; cl10555
224308009476	regulatory protein, yteA family; Region: bacill_yteA; TIGR02890
224308009477	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
224308009478	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
224308009479	active site
224308009480	tetramer interface; other site
224308009481	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
224308009482	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
224308009483	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
224308009484	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
224308009485	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
224308009486	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224308009487	NAD(P) binding site [chemical binding]; other site
224308009488	active site
224308009489	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224308009490	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
224308009491	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
224308009492	spore coat protein YutH; Region: spore_yutH; TIGR02905
224308009493	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224308009494	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
224308009495	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
224308009496	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
224308009497	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
224308009498	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
224308009499	homodimer interface [polypeptide binding]; other site
224308009500	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
224308009501	active site pocket [active]
224308009502	glycogen synthase; Provisional; Region: glgA; PRK00654
224308009503	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
224308009504	ADP-binding pocket [chemical binding]; other site
224308009505	homodimer interface [polypeptide binding]; other site
224308009506	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
224308009507	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
224308009508	ligand binding site; other site
224308009509	oligomer interface; other site
224308009510	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
224308009511	dimer interface [polypeptide binding]; other site
224308009512	N-terminal domain interface [polypeptide binding]; other site
224308009513	sulfate 1 binding site; other site
224308009514	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
224308009515	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
224308009516	ligand binding site; other site
224308009517	oligomer interface; other site
224308009518	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
224308009519	dimer interface [polypeptide binding]; other site
224308009520	N-terminal domain interface [polypeptide binding]; other site
224308009521	sulfate 1 binding site; other site
224308009522	alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515
224308009523	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
224308009524	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
224308009525	active site
224308009526	catalytic site [active]
224308009527	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
224308009528	Predicted membrane protein [Function unknown]; Region: COG3859
224308009529	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
224308009530	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308009531	Coenzyme A binding pocket [chemical binding]; other site
224308009532	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
224308009533	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
224308009534	DinB superfamily; Region: DinB_2; pfam12867
224308009535	MOSC domain; Region: MOSC; pfam03473
224308009536	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
224308009537	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
224308009538	active site
224308009539	NAD binding site [chemical binding]; other site
224308009540	metal binding site [ion binding]; metal-binding site
224308009541	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
224308009542	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
224308009543	tetramerization interface [polypeptide binding]; other site
224308009544	NAD(P) binding site [chemical binding]; other site
224308009545	catalytic residues [active]
224308009546	Predicted transcriptional regulators [Transcription]; Region: COG1510
224308009547	MarR family; Region: MarR_2; pfam12802
224308009548	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
224308009549	TrkA-N domain; Region: TrkA_N; pfam02254
224308009550	TrkA-C domain; Region: TrkA_C; pfam02080
224308009551	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
224308009552	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
224308009553	Predicted membrane protein [Function unknown]; Region: COG4682
224308009554	yiaA/B two helix domain; Region: YiaAB; pfam05360
224308009555	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
224308009556	SH3-like domain; Region: SH3_8; pfam13457
224308009557	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308009558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308009559	putative substrate translocation pore; other site
224308009560	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
224308009561	undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753
224308009562	Domain of unknown function DUF20; Region: UPF0118; pfam01594
224308009563	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
224308009564	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224308009565	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
224308009566	L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134
224308009567	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
224308009568	Domain of unknown function (DUF718); Region: DUF718; cl01281
224308009569	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
224308009570	N- and C-terminal domain interface [polypeptide binding]; other site
224308009571	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
224308009572	active site
224308009573	putative catalytic site [active]
224308009574	metal binding site [ion binding]; metal-binding site
224308009575	ATP binding site [chemical binding]; other site
224308009576	carbohydrate binding site [chemical binding]; other site
224308009577	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224308009578	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
224308009579	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
224308009580	short chain dehydrogenase; Validated; Region: PRK08324
224308009581	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
224308009582	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
224308009583	putative NAD(P) binding site [chemical binding]; other site
224308009584	active site
224308009585	Homologues of the ligand binding domain of Tar; Region: TarH; smart00319
224308009586	Cache domain; Region: Cache_1; pfam02743
224308009587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308009588	dimerization interface [polypeptide binding]; other site
224308009589	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
224308009590	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308009591	dimer interface [polypeptide binding]; other site
224308009592	putative CheW interface [polypeptide binding]; other site
224308009593	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308009594	Homologues of the ligand binding domain of Tar; Region: TarH; smart00319
224308009595	Cache domain; Region: Cache_1; pfam02743
224308009596	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308009597	dimerization interface [polypeptide binding]; other site
224308009598	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308009599	dimer interface [polypeptide binding]; other site
224308009600	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
224308009601	putative CheW interface [polypeptide binding]; other site
224308009602	Tar ligand binding domain homologue; Region: TarH; pfam02203
224308009603	Cache domain; Region: Cache_1; pfam02743
224308009604	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
224308009605	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308009606	dimerization interface [polypeptide binding]; other site
224308009607	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308009608	dimer interface [polypeptide binding]; other site
224308009609	putative CheW interface [polypeptide binding]; other site
224308009610	Homologues of the ligand binding domain of Tar; Region: TarH; smart00319
224308009611	Cache domain; Region: Cache_1; pfam02743
224308009612	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308009613	dimerization interface [polypeptide binding]; other site
224308009614	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
224308009615	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308009616	dimer interface [polypeptide binding]; other site
224308009617	putative CheW interface [polypeptide binding]; other site
224308009618	transglutaminase; Provisional; Region: tgl; PRK03187
224308009619	secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ
224308009620	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
224308009621	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
224308009622	Ca binding site [ion binding]; other site
224308009623	active site
224308009624	catalytic site [active]
224308009625	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
224308009626	Domain of unknown function DUF21; Region: DUF21; pfam01595
224308009627	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224308009628	Transporter associated domain; Region: CorC_HlyC; smart01091
224308009629	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
224308009630	Membrane-integrating protein Mistic; Region: Mistic; pfam11458
224308009631	Ion channel; Region: Ion_trans_2; pfam07885
224308009632	TrkA-N domain; Region: TrkA_N; pfam02254
224308009633	YugN-like family; Region: YugN; pfam08868
224308009634	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
224308009635	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
224308009636	active site
224308009637	dimer interface [polypeptide binding]; other site
224308009638	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
224308009639	dimer interface [polypeptide binding]; other site
224308009640	active site
224308009641	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
224308009642	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
224308009643	dimer interface [polypeptide binding]; other site
224308009644	active site
224308009645	metal binding site [ion binding]; metal-binding site
224308009646	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
224308009647	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
224308009648	dimer interface [polypeptide binding]; other site
224308009649	active site
224308009650	metal binding site [ion binding]; metal-binding site
224308009651	Uncharacterized conserved protein [Function unknown]; Region: COG2155
224308009652	general stress protein 13; Validated; Region: PRK08059
224308009653	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
224308009654	RNA binding site [nucleotide binding]; other site
224308009655	hypothetical protein; Validated; Region: PRK07682
224308009656	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308009657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308009658	homodimer interface [polypeptide binding]; other site
224308009659	catalytic residue [active]
224308009660	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
224308009661	AsnC family; Region: AsnC_trans_reg; pfam01037
224308009662	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308009663	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
224308009664	nucleophilic elbow; other site
224308009665	catalytic triad; other site
224308009666	Domain of unknown function (DUF1871); Region: DUF1871; pfam08958
224308009667	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
224308009668	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308009669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308009670	homodimer interface [polypeptide binding]; other site
224308009671	catalytic residue [active]
224308009672	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308009673	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308009674	dimer interface [polypeptide binding]; other site
224308009675	phosphorylation site [posttranslational modification]
224308009676	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308009677	ATP binding site [chemical binding]; other site
224308009678	Mg2+ binding site [ion binding]; other site
224308009679	G-X-G motif; other site
224308009680	Kinase associated protein B; Region: KapB; pfam08810
224308009681	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
224308009682	active site
224308009683	catalytic site [active]
224308009684	substrate binding site [chemical binding]; other site
224308009685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308009686	drug efflux system protein MdtG; Provisional; Region: PRK09874
224308009687	putative substrate translocation pore; other site
224308009688	Transglycosylase; Region: Transgly; pfam00912
224308009689	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
224308009690	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
224308009691	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
224308009692	sensory histidine kinase DcuS; Provisional; Region: PRK11086
224308009693	PAS domain; Region: PAS; smart00091
224308009694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308009695	ATP binding site [chemical binding]; other site
224308009696	G-X-G motif; other site
224308009697	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
224308009698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308009699	active site
224308009700	phosphorylation site [posttranslational modification]
224308009701	intermolecular recognition site; other site
224308009702	dimerization interface [polypeptide binding]; other site
224308009703	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
224308009704	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
224308009705	ligand binding site [chemical binding]; other site
224308009706	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
224308009707	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
224308009708	Walker A/P-loop; other site
224308009709	ATP binding site [chemical binding]; other site
224308009710	Q-loop/lid; other site
224308009711	ABC transporter signature motif; other site
224308009712	Walker B; other site
224308009713	D-loop; other site
224308009714	H-loop/switch region; other site
224308009715	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
224308009716	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
224308009717	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
224308009718	TM-ABC transporter signature motif; other site
224308009719	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
224308009720	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
224308009721	TM-ABC transporter signature motif; other site
224308009722	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
224308009723	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
224308009724	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224308009725	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
224308009726	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
224308009727	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
224308009728	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
224308009729	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224308009730	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
224308009731	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
224308009732	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
224308009733	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
224308009734	CoenzymeA binding site [chemical binding]; other site
224308009735	subunit interaction site [polypeptide binding]; other site
224308009736	PHB binding site; other site
224308009737	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308009738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308009739	active site
224308009740	phosphorylation site [posttranslational modification]
224308009741	intermolecular recognition site; other site
224308009742	dimerization interface [polypeptide binding]; other site
224308009743	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308009744	DNA binding residues [nucleotide binding]
224308009745	dimerization interface [polypeptide binding]; other site
224308009746	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
224308009747	Histidine kinase; Region: HisKA_3; pfam07730
224308009748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308009749	ATP binding site [chemical binding]; other site
224308009750	Mg2+ binding site [ion binding]; other site
224308009751	G-X-G motif; other site
224308009752	Bacillus competence pheromone ComX; Region: ComX; pfam05952
224308009753	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
224308009754	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
224308009755	substrate binding pocket [chemical binding]; other site
224308009756	substrate-Mg2+ binding site; other site
224308009757	aspartate-rich region 1; other site
224308009758	DegQ (SacQ) family; Region: DegQ; pfam08181
224308009759	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
224308009760	EAL domain; Region: EAL; pfam00563
224308009761	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
224308009762	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
224308009763	active site
224308009764	Isochorismatase family; Region: Isochorismatase; pfam00857
224308009765	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
224308009766	catalytic triad [active]
224308009767	conserved cis-peptide bond; other site
224308009768	Uncharacterized conserved protein [Function unknown]; Region: COG5506
224308009769	YueH-like protein; Region: YueH; pfam14166
224308009770	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
224308009771	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
224308009772	Domain of unknown function DUF20; Region: UPF0118; pfam01594
224308009773	Uncharacterized conserved small protein [Function unknown]; Region: COG5428
224308009774	Protein of unknown function (DUF2642); Region: DUF2642; pfam10842
224308009775	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
224308009776	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224308009777	Zn2+ binding site [ion binding]; other site
224308009778	Mg2+ binding site [ion binding]; other site
224308009779	short chain dehydrogenase; Provisional; Region: PRK06924
224308009780	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
224308009781	NADP binding site [chemical binding]; other site
224308009782	homodimer interface [polypeptide binding]; other site
224308009783	active site
224308009784	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
224308009785	Predicted membrane protein [Function unknown]; Region: COG1511
224308009786	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
224308009787	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
224308009788	exosortase F-associated protein; Region: flavo_near_exo; TIGR04127
224308009789	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
224308009790	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
224308009791	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
224308009792	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
224308009793	Domain of unknown function DUF87; Region: DUF87; pfam01935
224308009794	Predicted membrane protein [Function unknown]; Region: COG4499
224308009795	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
224308009796	Uncharacterized small protein [Function unknown]; Region: COG5417
224308009797	Ubiquitin homologues; Region: UBQ; smart00213
224308009798	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
224308009799	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
224308009800	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
224308009801	alanine dehydrogenase; Region: alaDH; TIGR00518
224308009802	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
224308009803	hexamer interface [polypeptide binding]; other site
224308009804	ligand binding site [chemical binding]; other site
224308009805	putative active site [active]
224308009806	NAD(P) binding site [chemical binding]; other site
224308009807	Uncharacterized conserved protein [Function unknown]; Region: COG5634
224308009808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
224308009809	Condensation domain; Region: Condensation; pfam00668
224308009810	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
224308009811	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
224308009812	acyl-activating enzyme (AAE) consensus motif; other site
224308009813	AMP binding site [chemical binding]; other site
224308009814	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308009815	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
224308009816	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
224308009817	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
224308009818	acyl-activating enzyme (AAE) consensus motif; other site
224308009819	AMP binding site [chemical binding]; other site
224308009820	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
224308009821	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
224308009822	hydrophobic substrate binding pocket; other site
224308009823	Isochorismatase family; Region: Isochorismatase; pfam00857
224308009824	active site
224308009825	conserved cis-peptide bond; other site
224308009826	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
224308009827	2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275
224308009828	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
224308009829	acyl-activating enzyme (AAE) consensus motif; other site
224308009830	active site
224308009831	AMP binding site [chemical binding]; other site
224308009832	substrate binding site [chemical binding]; other site
224308009833	isochorismate synthase DhbC; Validated; Region: PRK06923
224308009834	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
224308009835	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
224308009836	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
224308009837	putative NAD(P) binding site [chemical binding]; other site
224308009838	active site
224308009839	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
224308009840	Putative esterase; Region: Esterase; pfam00756
224308009841	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
224308009842	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
224308009843	Moco binding site; other site
224308009844	metal coordination site [ion binding]; other site
224308009845	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
224308009846	Predicted permease [General function prediction only]; Region: COG2056
224308009847	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
224308009848	multifunctional aminopeptidase A; Provisional; Region: PRK00913
224308009849	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
224308009850	interface (dimer of trimers) [polypeptide binding]; other site
224308009851	Substrate-binding/catalytic site; other site
224308009852	Zn-binding sites [ion binding]; other site
224308009853	Divergent PAP2 family; Region: DUF212; pfam02681
224308009854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
224308009855	Putative membrane protein; Region: YuiB; pfam14068
224308009856	Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107
224308009857	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
224308009858	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308009859	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
224308009860	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
224308009861	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308009862	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
224308009863	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
224308009864	active site
224308009865	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
224308009866	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
224308009867	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308009868	Coenzyme A binding pocket [chemical binding]; other site
224308009869	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
224308009870	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
224308009871	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
224308009872	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
224308009873	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
224308009874	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
224308009875	Nucleoside recognition; Region: Gate; pfam07670
224308009876	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
224308009877	hypothetical protein; Provisional; Region: PRK13669
224308009878	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
224308009879	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308009880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
224308009881	NifU-like domain; Region: NifU; pfam01106
224308009882	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
224308009883	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
224308009884	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
224308009885	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
224308009886	homoserine kinase; Region: thrB; TIGR00191
224308009887	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
224308009888	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
224308009889	threonine synthase; Reviewed; Region: PRK06721
224308009890	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
224308009891	homodimer interface [polypeptide binding]; other site
224308009892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308009893	catalytic residue [active]
224308009894	homoserine dehydrogenase; Provisional; Region: PRK06349
224308009895	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
224308009896	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
224308009897	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
224308009898	spore coat protein YutH; Region: spore_yutH; TIGR02905
224308009899	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
224308009900	tetramer interfaces [polypeptide binding]; other site
224308009901	binuclear metal-binding site [ion binding]; other site
224308009902	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
224308009903	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308009904	active site
224308009905	motif I; other site
224308009906	motif II; other site
224308009907	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308009908	Uncharacterized conserved protein [Function unknown]; Region: COG2445
224308009909	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
224308009910	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
224308009911	lipoyl synthase; Provisional; Region: PRK05481
224308009912	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308009913	FeS/SAM binding site; other site
224308009914	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
224308009915	Peptidase family M23; Region: Peptidase_M23; pfam01551
224308009916	sporulation protein YunB; Region: spo_yunB; TIGR02832
224308009917	Uncharacterized conserved protein [Function unknown]; Region: COG3377
224308009918	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
224308009919	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
224308009920	active site
224308009921	metal binding site [ion binding]; metal-binding site
224308009922	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
224308009923	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
224308009924	Uncharacterized conserved protein [Function unknown]; Region: COG1801
224308009925	allantoinase; Provisional; Region: PRK06189
224308009926	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
224308009927	active site
224308009928	DRTGG domain; Region: DRTGG; pfam07085
224308009929	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
224308009930	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
224308009931	xanthine permease; Region: pbuX; TIGR03173
224308009932	xanthine permease; Region: pbuX; TIGR03173
224308009933	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
224308009934	Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648
224308009935	Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the...; Region: Uricase; cd00445
224308009936	tetramer interface [polypeptide binding]; other site
224308009937	active site
224308009938	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cd05469
224308009939	active site
224308009940	homotetramer interface [polypeptide binding]; other site
224308009941	xanthine dehydrogenase E subunit; Region: pucE; TIGR03198
224308009942	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
224308009943	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
224308009944	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
224308009945	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
224308009946	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
224308009947	xanthine dehydrogenase C subunit; Region: pucC; TIGR03199
224308009948	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
224308009949	Ligand binding site; other site
224308009950	metal-binding site
224308009951	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
224308009952	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
224308009953	XdhC Rossmann domain; Region: XdhC_C; pfam13478
224308009954	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
224308009955	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224308009956	catalytic residue [active]
224308009957	allantoate amidohydrolase; Reviewed; Region: PRK09290
224308009958	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
224308009959	active site
224308009960	metal binding site [ion binding]; metal-binding site
224308009961	dimer interface [polypeptide binding]; other site
224308009962	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
224308009963	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
224308009964	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
224308009965	Walker A/P-loop; other site
224308009966	ATP binding site [chemical binding]; other site
224308009967	Q-loop/lid; other site
224308009968	ABC transporter signature motif; other site
224308009969	Walker B; other site
224308009970	D-loop; other site
224308009971	H-loop/switch region; other site
224308009972	TOBE domain; Region: TOBE_2; pfam08402
224308009973	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
224308009974	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308009975	DNA-binding site [nucleotide binding]; DNA binding site
224308009976	UTRA domain; Region: UTRA; pfam07702
224308009977	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224308009978	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
224308009979	substrate binding site [chemical binding]; other site
224308009980	ATP binding site [chemical binding]; other site
224308009981	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224308009982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308009983	dimer interface [polypeptide binding]; other site
224308009984	conserved gate region; other site
224308009985	putative PBP binding loops; other site
224308009986	ABC-ATPase subunit interface; other site
224308009987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308009988	dimer interface [polypeptide binding]; other site
224308009989	conserved gate region; other site
224308009990	putative PBP binding loops; other site
224308009991	ABC-ATPase subunit interface; other site
224308009992	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
224308009993	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
224308009994	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
224308009995	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
224308009996	putative active site [active]
224308009997	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
224308009998	dimer interface [polypeptide binding]; other site
224308009999	active site
224308010000	Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322
224308010001	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
224308010002	GIY-YIG motif/motif A; other site
224308010003	active site
224308010004	catalytic site [active]
224308010005	putative DNA binding site [nucleotide binding]; other site
224308010006	metal binding site [ion binding]; metal-binding site
224308010007	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
224308010008	hydroxyglutarate oxidase; Provisional; Region: PRK11728
224308010009	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308010010	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
224308010011	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308010012	dimerization interface [polypeptide binding]; other site
224308010013	putative DNA binding site [nucleotide binding]; other site
224308010014	putative Zn2+ binding site [ion binding]; other site
224308010015	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
224308010016	FeS assembly protein SufB; Region: sufB; TIGR01980
224308010017	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
224308010018	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
224308010019	trimerization site [polypeptide binding]; other site
224308010020	active site
224308010021	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
224308010022	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
224308010023	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224308010024	catalytic residue [active]
224308010025	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
224308010026	FeS assembly protein SufD; Region: sufD; TIGR01981
224308010027	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
224308010028	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
224308010029	Walker A/P-loop; other site
224308010030	ATP binding site [chemical binding]; other site
224308010031	Q-loop/lid; other site
224308010032	ABC transporter signature motif; other site
224308010033	Walker B; other site
224308010034	D-loop; other site
224308010035	H-loop/switch region; other site
224308010036	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
224308010037	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
224308010038	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
224308010039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010040	conserved gate region; other site
224308010041	ABC-ATPase subunit interface; other site
224308010042	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
224308010043	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
224308010044	Walker A/P-loop; other site
224308010045	ATP binding site [chemical binding]; other site
224308010046	Q-loop/lid; other site
224308010047	ABC transporter signature motif; other site
224308010048	Walker B; other site
224308010049	D-loop; other site
224308010050	H-loop/switch region; other site
224308010051	NIL domain; Region: NIL; pfam09383
224308010052	SCP-2 sterol transfer family; Region: SCP2; pfam02036
224308010053	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224308010054	catalytic residues [active]
224308010055	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
224308010056	putative active site [active]
224308010057	putative metal binding site [ion binding]; other site
224308010058	Protein of unknown function (DUF2553); Region: DUF2553; pfam10830
224308010059	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
224308010060	lipoyl attachment site [posttranslational modification]; other site
224308010061	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
224308010062	ArsC family; Region: ArsC; pfam03960
224308010063	putative ArsC-like catalytic residues; other site
224308010064	putative TRX-like catalytic residues [active]
224308010065	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
224308010066	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224308010067	active site
224308010068	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
224308010069	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
224308010070	dimer interface [polypeptide binding]; other site
224308010071	active site
224308010072	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
224308010073	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
224308010074	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
224308010075	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
224308010076	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
224308010077	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224308010078	substrate binding site [chemical binding]; other site
224308010079	oxyanion hole (OAH) forming residues; other site
224308010080	trimer interface [polypeptide binding]; other site
224308010081	Proline dehydrogenase; Region: Pro_dh; pfam01619
224308010082	Coat F domain; Region: Coat_F; pfam07875
224308010083	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308010084	MarR family; Region: MarR; pfam01047
224308010085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308010086	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308010087	putative substrate translocation pore; other site
224308010088	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
224308010089	classical (c) SDRs; Region: SDR_c; cd05233
224308010090	active site
224308010091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224308010092	NAD(P) binding site [chemical binding]; other site
224308010093	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308010094	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308010095	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224308010096	dimerization interface [polypeptide binding]; other site
224308010097	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
224308010098	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
224308010099	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
224308010100	Walker A/P-loop; other site
224308010101	ATP binding site [chemical binding]; other site
224308010102	Q-loop/lid; other site
224308010103	ABC transporter signature motif; other site
224308010104	Walker B; other site
224308010105	D-loop; other site
224308010106	H-loop/switch region; other site
224308010107	YusW-like protein; Region: YusW; pfam14039
224308010108	Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 11741842; Product type e: enzyme
224308010109	Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; PubMedId: 11741842; Product type e: enzyme
224308010110	short chain dehydrogenase; Provisional; Region: PRK06914
224308010111	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
224308010112	NADP binding site [chemical binding]; other site
224308010113	active site
224308010114	steroid binding site; other site
224308010115	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
224308010116	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
224308010117	dimerization interface [polypeptide binding]; other site
224308010118	DPS ferroxidase diiron center [ion binding]; other site
224308010119	ion pore; other site
224308010120	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
224308010121	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
224308010122	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224308010123	protein binding site [polypeptide binding]; other site
224308010124	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308010125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308010126	active site
224308010127	phosphorylation site [posttranslational modification]
224308010128	intermolecular recognition site; other site
224308010129	dimerization interface [polypeptide binding]; other site
224308010130	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308010131	DNA binding site [nucleotide binding]
224308010132	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308010133	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308010134	dimerization interface [polypeptide binding]; other site
224308010135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308010136	dimer interface [polypeptide binding]; other site
224308010137	phosphorylation site [posttranslational modification]
224308010138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308010139	ATP binding site [chemical binding]; other site
224308010140	Mg2+ binding site [ion binding]; other site
224308010141	G-X-G motif; other site
224308010142	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308010143	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308010144	fumarate hydratase; Reviewed; Region: fumC; PRK00485
224308010145	Class II fumarases; Region: Fumarase_classII; cd01362
224308010146	active site
224308010147	tetramer interface [polypeptide binding]; other site
224308010148	Protein of unknown function (DUF3970); Region: DUF3970; pfam13113
224308010149	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
224308010150	Spore germination protein; Region: Spore_permease; pfam03845
224308010151	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
224308010152	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
224308010153	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308010154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308010155	active site
224308010156	phosphorylation site [posttranslational modification]
224308010157	intermolecular recognition site; other site
224308010158	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308010159	DNA binding residues [nucleotide binding]
224308010160	dimerization interface [polypeptide binding]; other site
224308010161	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
224308010162	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308010163	dimerization interface [polypeptide binding]; other site
224308010164	Histidine kinase; Region: HisKA_3; pfam07730
224308010165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308010166	ATP binding site [chemical binding]; other site
224308010167	Mg2+ binding site [ion binding]; other site
224308010168	G-X-G motif; other site
224308010169	Predicted membrane protein [Function unknown]; Region: COG4758
224308010170	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
224308010171	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
224308010172	Uncharacterized conserved protein [Function unknown]; Region: COG3595
224308010173	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
224308010174	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
224308010175	PspA/IM30 family; Region: PspA_IM30; pfam04012
224308010176	H+ Antiporter protein; Region: 2A0121; TIGR00900
224308010177	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
224308010178	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
224308010179	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
224308010180	Walker A/P-loop; other site
224308010181	ATP binding site [chemical binding]; other site
224308010182	Q-loop/lid; other site
224308010183	ABC transporter signature motif; other site
224308010184	Walker B; other site
224308010185	D-loop; other site
224308010186	H-loop/switch region; other site
224308010187	Adenosylcobinamide amidohydrolase [Coenzyme metabolism]; Region: cbiZ; COG1865
224308010188	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
224308010189	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308010190	ABC-ATPase subunit  interface; other site
224308010191	dimer interface [polypeptide binding]; other site
224308010192	putative PBP binding regions; other site
224308010193	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
224308010194	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
224308010195	putative binding site residues; other site
224308010196	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
224308010197	classical (c) SDRs; Region: SDR_c; cd05233
224308010198	NAD(P) binding site [chemical binding]; other site
224308010199	active site
224308010200	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
224308010201	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308010202	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308010203	dimer interface [polypeptide binding]; other site
224308010204	phosphorylation site [posttranslational modification]
224308010205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308010206	ATP binding site [chemical binding]; other site
224308010207	Mg2+ binding site [ion binding]; other site
224308010208	G-X-G motif; other site
224308010209	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308010210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308010211	active site
224308010212	phosphorylation site [posttranslational modification]
224308010213	intermolecular recognition site; other site
224308010214	dimerization interface [polypeptide binding]; other site
224308010215	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308010216	DNA binding site [nucleotide binding]
224308010217	hypothetical protein; Provisional; Region: PRK14082
224308010218	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
224308010219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308010220	DNA binding residues [nucleotide binding]
224308010221	YvrJ protein family; Region: YvrJ; pfam12841
224308010222	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
224308010223	Cupin; Region: Cupin_1; smart00835
224308010224	Cupin; Region: Cupin_1; smart00835
224308010225	Regulatory protein YrvL; Region: YrvL; pfam14184
224308010226	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
224308010227	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
224308010228	FtsX-like permease family; Region: FtsX; pfam02687
224308010229	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224308010230	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
224308010231	Walker A/P-loop; other site
224308010232	ATP binding site [chemical binding]; other site
224308010233	Q-loop/lid; other site
224308010234	ABC transporter signature motif; other site
224308010235	Walker B; other site
224308010236	D-loop; other site
224308010237	H-loop/switch region; other site
224308010238	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
224308010239	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
224308010240	DNA damage checkpoint protein; Region: LCD1; pfam09798
224308010241	HlyD family secretion protein; Region: HlyD_3; pfam13437
224308010242	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
224308010243	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
224308010244	Walker A/P-loop; other site
224308010245	ATP binding site [chemical binding]; other site
224308010246	Q-loop/lid; other site
224308010247	ABC transporter signature motif; other site
224308010248	Walker B; other site
224308010249	D-loop; other site
224308010250	H-loop/switch region; other site
224308010251	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
224308010252	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308010253	ABC-ATPase subunit  interface; other site
224308010254	dimer interface [polypeptide binding]; other site
224308010255	putative PBP binding regions; other site
224308010256	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
224308010257	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
224308010258	ABC-ATPase subunit  interface; other site
224308010259	dimer interface [polypeptide binding]; other site
224308010260	putative PBP binding regions; other site
224308010261	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
224308010262	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
224308010263	putative ligand binding residues [chemical binding]; other site
224308010264	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
224308010265	small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863
224308010266	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
224308010267	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
224308010268	Sulfatase; Region: Sulfatase; pfam00884
224308010269	DNA binding domain, excisionase family; Region: excise; TIGR01764
224308010270	Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910
224308010271	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
224308010272	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
224308010273	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
224308010274	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010275	dimer interface [polypeptide binding]; other site
224308010276	conserved gate region; other site
224308010277	putative PBP binding loops; other site
224308010278	ABC-ATPase subunit interface; other site
224308010279	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224308010280	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
224308010281	active site
224308010282	catalytic tetrad [active]
224308010283	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
224308010284	sulfite reductase subunit beta; Provisional; Region: PRK13504
224308010285	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224308010286	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224308010287	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
224308010288	Flavodoxin; Region: Flavodoxin_1; pfam00258
224308010289	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
224308010290	FAD binding pocket [chemical binding]; other site
224308010291	FAD binding motif [chemical binding]; other site
224308010292	catalytic residues [active]
224308010293	NAD binding pocket [chemical binding]; other site
224308010294	phosphate binding motif [ion binding]; other site
224308010295	beta-alpha-beta structure motif; other site
224308010296	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
224308010297	Part of AAA domain; Region: AAA_19; pfam13245
224308010298	Family description; Region: UvrD_C_2; pfam13538
224308010299	Predicted membrane protein [Function unknown]; Region: COG2860
224308010300	UPF0126 domain; Region: UPF0126; pfam03458
224308010301	UPF0126 domain; Region: UPF0126; pfam03458
224308010302	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
224308010303	Thioredoxin; Region: Thioredoxin_4; pfam13462
224308010304	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
224308010305	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
224308010306	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224308010307	metal-binding site [ion binding]
224308010308	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224308010309	Soluble P-type ATPase [General function prediction only]; Region: COG4087
224308010310	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
224308010311	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224308010312	metal-binding site [ion binding]
224308010313	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
224308010314	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224308010315	metal-binding site [ion binding]
224308010316	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224308010317	Soluble P-type ATPase [General function prediction only]; Region: COG4087
224308010318	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
224308010319	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224308010320	metal-binding site [ion binding]
224308010321	Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157
224308010322	putative homodimer interface [polypeptide binding]; other site
224308010323	putative homotetramer interface [polypeptide binding]; other site
224308010324	allosteric switch controlling residues; other site
224308010325	putative metal binding site [ion binding]; other site
224308010326	putative homodimer-homodimer interface [polypeptide binding]; other site
224308010327	putative oxidoreductase; Provisional; Region: PRK11579
224308010328	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
224308010329	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
224308010330	azoreductase; Reviewed; Region: PRK00170
224308010331	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
224308010332	Predicted membrane protein [Function unknown]; Region: COG1289
224308010333	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
224308010334	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
224308010335	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
224308010336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308010337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308010338	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224308010339	classical (c) SDRs; Region: SDR_c; cd05233
224308010340	NAD(P) binding site [chemical binding]; other site
224308010341	active site
224308010342	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
224308010343	SmpB-tmRNA interface; other site
224308010344	ribonuclease R; Region: RNase_R; TIGR02063
224308010345	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
224308010346	Cold shock protein domain; Region: CSP; smart00357
224308010347	RNB domain; Region: RNB; pfam00773
224308010348	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
224308010349	RNA binding site [nucleotide binding]; other site
224308010350	Esterase/lipase [General function prediction only]; Region: COG1647
224308010351	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
224308010352	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308010353	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308010354	salt bridge; other site
224308010355	non-specific DNA binding site [nucleotide binding]; other site
224308010356	sequence-specific DNA binding site [nucleotide binding]; other site
224308010357	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308010358	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308010359	non-specific DNA binding site [nucleotide binding]; other site
224308010360	salt bridge; other site
224308010361	sequence-specific DNA binding site [nucleotide binding]; other site
224308010362	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308010363	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308010364	non-specific DNA binding site [nucleotide binding]; other site
224308010365	salt bridge; other site
224308010366	sequence-specific DNA binding site [nucleotide binding]; other site
224308010367	Predicted transcriptional regulators [Transcription]; Region: COG1733
224308010368	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
224308010369	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
224308010370	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308010371	dimerization interface [polypeptide binding]; other site
224308010372	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
224308010373	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
224308010374	dimer interface [polypeptide binding]; other site
224308010375	putative CheW interface [polypeptide binding]; other site
224308010376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010377	dimer interface [polypeptide binding]; other site
224308010378	conserved gate region; other site
224308010379	putative PBP binding loops; other site
224308010380	ABC-ATPase subunit interface; other site
224308010381	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
224308010382	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
224308010383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010384	dimer interface [polypeptide binding]; other site
224308010385	conserved gate region; other site
224308010386	putative PBP binding loops; other site
224308010387	ABC-ATPase subunit interface; other site
224308010388	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
224308010389	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
224308010390	Walker A/P-loop; other site
224308010391	ATP binding site [chemical binding]; other site
224308010392	Q-loop/lid; other site
224308010393	ABC transporter signature motif; other site
224308010394	Walker B; other site
224308010395	D-loop; other site
224308010396	H-loop/switch region; other site
224308010397	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
224308010398	Predicted transcriptional regulators [Transcription]; Region: COG1510
224308010399	MarR family; Region: MarR_2; pfam12802
224308010400	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
224308010401	antimicrobial peptide system protein, SdpB family; Region: export_SdpB; TIGR04033
224308010402	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
224308010403	Predicted integral membrane protein [Function unknown]; Region: COG5658
224308010404	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
224308010405	SdpI/YhfL protein family; Region: SdpI; pfam13630
224308010406	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308010407	dimerization interface [polypeptide binding]; other site
224308010408	putative DNA binding site [nucleotide binding]; other site
224308010409	putative Zn2+ binding site [ion binding]; other site
224308010410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010411	dimer interface [polypeptide binding]; other site
224308010412	conserved gate region; other site
224308010413	putative PBP binding loops; other site
224308010414	ABC-ATPase subunit interface; other site
224308010415	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
224308010416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010417	dimer interface [polypeptide binding]; other site
224308010418	conserved gate region; other site
224308010419	putative PBP binding loops; other site
224308010420	ABC-ATPase subunit interface; other site
224308010421	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
224308010422	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
224308010423	Walker A/P-loop; other site
224308010424	ATP binding site [chemical binding]; other site
224308010425	Q-loop/lid; other site
224308010426	ABC transporter signature motif; other site
224308010427	Walker B; other site
224308010428	D-loop; other site
224308010429	H-loop/switch region; other site
224308010430	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
224308010431	Predicted transcriptional regulators [Transcription]; Region: COG1510
224308010432	MarR family; Region: MarR_2; pfam12802
224308010433	membrane protein, MarC family; Region: TIGR00427
224308010434	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
224308010435	pentamer interface [polypeptide binding]; other site
224308010436	dodecaamer interface [polypeptide binding]; other site
224308010437	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
224308010438	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
224308010439	Double zinc ribbon; Region: DZR; pfam12773
224308010440	Predicted membrane protein [Function unknown]; Region: COG4640
224308010441	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
224308010442	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308010443	Coenzyme A binding pocket [chemical binding]; other site
224308010444	enolase; Provisional; Region: eno; PRK00077
224308010445	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
224308010446	dimer interface [polypeptide binding]; other site
224308010447	metal binding site [ion binding]; metal-binding site
224308010448	substrate binding pocket [chemical binding]; other site
224308010449	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
224308010450	phosphoglyceromutase; Provisional; Region: PRK05434
224308010451	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
224308010452	triosephosphate isomerase; Provisional; Region: PRK14565
224308010453	substrate binding site [chemical binding]; other site
224308010454	dimer interface [polypeptide binding]; other site
224308010455	catalytic triad [active]
224308010456	Phosphoglycerate kinase; Region: PGK; pfam00162
224308010457	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
224308010458	substrate binding site [chemical binding]; other site
224308010459	hinge regions; other site
224308010460	ADP binding site [chemical binding]; other site
224308010461	catalytic site [active]
224308010462	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
224308010463	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
224308010464	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
224308010465	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
224308010466	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
224308010467	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
224308010468	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308010469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308010470	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308010471	DNA-binding site [nucleotide binding]; DNA binding site
224308010472	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308010473	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
224308010474	putative dimerization interface [polypeptide binding]; other site
224308010475	putative ligand binding site [chemical binding]; other site
224308010476	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
224308010477	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
224308010478	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
224308010479	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308010480	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308010481	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308010482	dimerization interface [polypeptide binding]; other site
224308010483	EamA-like transporter family; Region: EamA; pfam00892
224308010484	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
224308010485	EamA-like transporter family; Region: EamA; pfam00892
224308010486	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
224308010487	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
224308010488	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
224308010489	active site
224308010490	Uncharacterized conserved protein [Function unknown]; Region: COG1556
224308010491	iron-sulfur cluster-binding protein; Region: TIGR00273
224308010492	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
224308010493	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
224308010494	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
224308010495	Cysteine-rich domain; Region: CCG; pfam02754
224308010496	Cysteine-rich domain; Region: CCG; pfam02754
224308010497	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308010498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308010499	active site
224308010500	phosphorylation site [posttranslational modification]
224308010501	intermolecular recognition site; other site
224308010502	dimerization interface [polypeptide binding]; other site
224308010503	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308010504	DNA binding residues [nucleotide binding]
224308010505	dimerization interface [polypeptide binding]; other site
224308010506	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
224308010507	Histidine kinase; Region: HisKA_3; pfam07730
224308010508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308010509	ATP binding site [chemical binding]; other site
224308010510	Mg2+ binding site [ion binding]; other site
224308010511	G-X-G motif; other site
224308010512	ABC-2 type transporter; Region: ABC2_membrane; cl17235
224308010513	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
224308010514	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
224308010515	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
224308010516	Walker A/P-loop; other site
224308010517	ATP binding site [chemical binding]; other site
224308010518	Q-loop/lid; other site
224308010519	ABC transporter signature motif; other site
224308010520	Walker B; other site
224308010521	D-loop; other site
224308010522	H-loop/switch region; other site
224308010523	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
224308010524	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
224308010525	catalytic site [active]
224308010526	PAS domain S-box; Region: sensory_box; TIGR00229
224308010527	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308010528	putative active site [active]
224308010529	heme pocket [chemical binding]; other site
224308010530	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
224308010531	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
224308010532	Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867
224308010533	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
224308010534	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
224308010535	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
224308010536	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
224308010537	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224308010538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010539	dimer interface [polypeptide binding]; other site
224308010540	conserved gate region; other site
224308010541	putative PBP binding loops; other site
224308010542	ABC-ATPase subunit interface; other site
224308010543	TM2 domain; Region: TM2; pfam05154
224308010544	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
224308010545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010546	dimer interface [polypeptide binding]; other site
224308010547	conserved gate region; other site
224308010548	ABC-ATPase subunit interface; other site
224308010549	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
224308010550	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
224308010551	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308010552	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308010553	DNA binding site [nucleotide binding]
224308010554	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
224308010555	putative dimerization interface [polypeptide binding]; other site
224308010556	putative ligand binding site [chemical binding]; other site
224308010557	Transcriptional regulators [Transcription]; Region: FadR; COG2186
224308010558	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308010559	DNA-binding site [nucleotide binding]; DNA binding site
224308010560	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
224308010561	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
224308010562	L-lactate permease; Region: Lactate_perm; pfam02652
224308010563	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
224308010564	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
224308010565	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
224308010566	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
224308010567	YvfG protein; Region: YvfG; pfam09628
224308010568	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
224308010569	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
224308010570	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
224308010571	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
224308010572	inhibitor-cofactor binding pocket; inhibition site
224308010573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308010574	catalytic residue [active]
224308010575	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
224308010576	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
224308010577	putative trimer interface [polypeptide binding]; other site
224308010578	putative CoA binding site [chemical binding]; other site
224308010579	Bacterial sugar transferase; Region: Bac_transf; pfam02397
224308010580	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
224308010581	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308010582	active site
224308010583	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
224308010584	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
224308010585	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308010586	active site
224308010587	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224308010588	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
224308010589	putative ADP-binding pocket [chemical binding]; other site
224308010590	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224308010591	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308010592	active site
224308010593	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
224308010594	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224308010595	putative ADP-binding pocket [chemical binding]; other site
224308010596	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
224308010597	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
224308010598	NAD(P) binding site [chemical binding]; other site
224308010599	homodimer interface [polypeptide binding]; other site
224308010600	substrate binding site [chemical binding]; other site
224308010601	active site
224308010602	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
224308010603	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
224308010604	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
224308010605	Chain length determinant protein; Region: Wzz; cl15801
224308010606	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
224308010607	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224308010608	non-specific DNA binding site [nucleotide binding]; other site
224308010609	salt bridge; other site
224308010610	sequence-specific DNA binding site [nucleotide binding]; other site
224308010611	Anti-repressor SinI; Region: SinI; pfam08671
224308010612	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
224308010613	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
224308010614	substrate binding pocket [chemical binding]; other site
224308010615	catalytic triad [active]
224308010616	Phenolic acid decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3479
224308010617	hypothetical protein; Provisional; Region: PRK00872
224308010618	Protein of unknown function (DUF3237); Region: DUF3237; cl07905
224308010619	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
224308010620	aspartate racemase; Region: asp_race; TIGR00035
224308010621	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
224308010622	Beta-lactamase; Region: Beta-lactamase; pfam00144
224308010623	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
224308010624	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
224308010625	active site
224308010626	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
224308010627	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
224308010628	substrate binding [chemical binding]; other site
224308010629	active site
224308010630	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
224308010631	amino acid transporter; Region: 2A0306; TIGR00909
224308010632	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308010633	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308010634	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
224308010635	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
224308010636	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
224308010637	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
224308010638	FAD binding domain; Region: FAD_binding_4; pfam01565
224308010639	Berberine and berberine like; Region: BBE; pfam08031
224308010640	Patatin [General function prediction only]; Region: COG3621
224308010641	Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213
224308010642	active site
224308010643	nucleophile elbow; other site
224308010644	Clp protease; Region: CLP_protease; pfam00574
224308010645	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
224308010646	oligomer interface [polypeptide binding]; other site
224308010647	active site residues [active]
224308010648	beta-phosphoglucomutase; Region: bPGM; TIGR01990
224308010649	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308010650	motif II; other site
224308010651	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
224308010652	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
224308010653	Ca binding site [ion binding]; other site
224308010654	active site
224308010655	catalytic site [active]
224308010656	maltose phosphorylase; Provisional; Region: PRK13807
224308010657	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
224308010658	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
224308010659	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
224308010660	Predicted integral membrane protein [Function unknown]; Region: COG5521
224308010661	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
224308010662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010663	dimer interface [polypeptide binding]; other site
224308010664	conserved gate region; other site
224308010665	ABC-ATPase subunit interface; other site
224308010666	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
224308010667	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308010668	dimer interface [polypeptide binding]; other site
224308010669	conserved gate region; other site
224308010670	putative PBP binding loops; other site
224308010671	ABC-ATPase subunit interface; other site
224308010672	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
224308010673	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
224308010674	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
224308010675	homodimer interface [polypeptide binding]; other site
224308010676	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
224308010677	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
224308010678	active site
224308010679	homodimer interface [polypeptide binding]; other site
224308010680	catalytic site [active]
224308010681	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308010682	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308010683	DNA binding site [nucleotide binding]
224308010684	domain linker motif; other site
224308010685	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
224308010686	ligand binding site [chemical binding]; other site
224308010687	dimerization interface [polypeptide binding]; other site
224308010688	TIGR00730 family protein; Region: TIGR00730
224308010689	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
224308010690	metal binding site [ion binding]; metal-binding site
224308010691	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
224308010692	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
224308010693	Sulfate transporter family; Region: Sulfate_transp; pfam00916
224308010694	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
224308010695	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
224308010696	active site clefts [active]
224308010697	zinc binding site [ion binding]; other site
224308010698	dimer interface [polypeptide binding]; other site
224308010699	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
224308010700	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
224308010701	dimerization interface [polypeptide binding]; other site
224308010702	ligand binding site [chemical binding]; other site
224308010703	NADP binding site [chemical binding]; other site
224308010704	catalytic site [active]
224308010705	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224308010706	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
224308010707	Walker A/P-loop; other site
224308010708	ATP binding site [chemical binding]; other site
224308010709	Q-loop/lid; other site
224308010710	ABC transporter signature motif; other site
224308010711	Walker B; other site
224308010712	D-loop; other site
224308010713	H-loop/switch region; other site
224308010714	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308010715	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
224308010716	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308010717	ATP binding site [chemical binding]; other site
224308010718	Mg2+ binding site [ion binding]; other site
224308010719	G-X-G motif; other site
224308010720	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308010721	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308010722	active site
224308010723	phosphorylation site [posttranslational modification]
224308010724	intermolecular recognition site; other site
224308010725	dimerization interface [polypeptide binding]; other site
224308010726	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308010727	DNA binding site [nucleotide binding]
224308010728	Lysis protein; Region: Lysis_col; pfam02402
224308010729	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
224308010730	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
224308010731	dimerization domain swap beta strand [polypeptide binding]; other site
224308010732	regulatory protein interface [polypeptide binding]; other site
224308010733	active site
224308010734	regulatory phosphorylation site [posttranslational modification]; other site
224308010735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
224308010736	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
224308010737	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
224308010738	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
224308010739	phosphate binding site [ion binding]; other site
224308010740	putative substrate binding pocket [chemical binding]; other site
224308010741	dimer interface [polypeptide binding]; other site
224308010742	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
224308010743	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
224308010744	putative active site [active]
224308010745	nucleotide binding site [chemical binding]; other site
224308010746	nudix motif; other site
224308010747	putative metal binding site [ion binding]; other site
224308010748	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
224308010749	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
224308010750	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308010751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
224308010752	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
224308010753	NlpC/P60 family; Region: NLPC_P60; pfam00877
224308010754	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308010755	binding surface
224308010756	TPR motif; other site
224308010757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308010758	TPR motif; other site
224308010759	binding surface
224308010760	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224308010761	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308010762	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224308010763	Walker A/P-loop; other site
224308010764	ATP binding site [chemical binding]; other site
224308010765	Q-loop/lid; other site
224308010766	ABC transporter signature motif; other site
224308010767	Walker B; other site
224308010768	D-loop; other site
224308010769	H-loop/switch region; other site
224308010770	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
224308010771	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
224308010772	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
224308010773	metal binding site [ion binding]; metal-binding site
224308010774	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
224308010775	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
224308010776	substrate binding site [chemical binding]; other site
224308010777	glutamase interaction surface [polypeptide binding]; other site
224308010778	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
224308010779	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
224308010780	catalytic residues [active]
224308010781	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
224308010782	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
224308010783	putative active site [active]
224308010784	oxyanion strand; other site
224308010785	catalytic triad [active]
224308010786	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
224308010787	putative active site pocket [active]
224308010788	4-fold oligomerization interface [polypeptide binding]; other site
224308010789	metal binding residues [ion binding]; metal-binding site
224308010790	3-fold/trimer interface [polypeptide binding]; other site
224308010791	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
224308010792	histidinol dehydrogenase; Region: hisD; TIGR00069
224308010793	NAD binding site [chemical binding]; other site
224308010794	dimerization interface [polypeptide binding]; other site
224308010795	product binding site; other site
224308010796	substrate binding site [chemical binding]; other site
224308010797	zinc binding site [ion binding]; other site
224308010798	catalytic residues [active]
224308010799	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
224308010800	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
224308010801	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
224308010802	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
224308010803	dimer interface [polypeptide binding]; other site
224308010804	motif 1; other site
224308010805	active site
224308010806	motif 2; other site
224308010807	motif 3; other site
224308010808	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
224308010809	putative active site [active]
224308010810	Pectate lyase; Region: Pectate_lyase; pfam03211
224308010811	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
224308010812	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
224308010813	CoA binding site [chemical binding]; other site
224308010814	active site
224308010815	pyrophosphatase PpaX; Provisional; Region: PRK13288
224308010816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308010817	motif II; other site
224308010818	Nucleoside recognition; Region: Gate; pfam07670
224308010819	Nucleoside recognition; Region: Gate; pfam07670
224308010820	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
224308010821	HPr kinase/phosphorylase; Provisional; Region: PRK05428
224308010822	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
224308010823	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
224308010824	Hpr binding site; other site
224308010825	active site
224308010826	homohexamer subunit interaction site [polypeptide binding]; other site
224308010827	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
224308010828	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
224308010829	active site
224308010830	dimer interface [polypeptide binding]; other site
224308010831	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
224308010832	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
224308010833	active site
224308010834	trimer interface [polypeptide binding]; other site
224308010835	allosteric site; other site
224308010836	active site lid [active]
224308010837	hexamer (dimer of trimers) interface [polypeptide binding]; other site
224308010838	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
224308010839	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308010840	DNA-binding site [nucleotide binding]; DNA binding site
224308010841	UTRA domain; Region: UTRA; pfam07702
224308010842	Lamin Tail Domain; Region: LTD; pfam00932
224308010843	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
224308010844	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224308010845	putative active site [active]
224308010846	putative metal binding site [ion binding]; other site
224308010847	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308010848	MarR family; Region: MarR; pfam01047
224308010849	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
224308010850	Cytochrome P450; Region: p450; cl12078
224308010851	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308010852	MarR family; Region: MarR; pfam01047
224308010853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308010854	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308010855	putative substrate translocation pore; other site
224308010856	Predicted membrane protein [Function unknown]; Region: COG1950
224308010857	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
224308010858	Uncharacterized conserved protein [Function unknown]; Region: COG3595
224308010859	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
224308010860	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
224308010861	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
224308010862	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
224308010863	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
224308010864	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
224308010865	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
224308010866	excinuclease ABC subunit B; Provisional; Region: PRK05298
224308010867	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308010868	ATP binding site [chemical binding]; other site
224308010869	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308010870	nucleotide binding region [chemical binding]; other site
224308010871	ATP-binding site [chemical binding]; other site
224308010872	Ultra-violet resistance protein B; Region: UvrB; pfam12344
224308010873	Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559
224308010874	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
224308010875	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
224308010876	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
224308010877	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308010878	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308010879	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308010880	putative substrate translocation pore; other site
224308010881	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
224308010882	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224308010883	Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process
224308010884	Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type cp: cell process
224308010885	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
224308010886	C-terminal peptidase (prc); Region: prc; TIGR00225
224308010887	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
224308010888	protein binding site [polypeptide binding]; other site
224308010889	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
224308010890	Catalytic dyad [active]
224308010891	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
224308010892	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
224308010893	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
224308010894	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
224308010895	ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292
224308010896	Walker A/P-loop; other site
224308010897	ATP binding site [chemical binding]; other site
224308010898	Q-loop/lid; other site
224308010899	ABC transporter signature motif; other site
224308010900	Walker B; other site
224308010901	D-loop; other site
224308010902	H-loop/switch region; other site
224308010903	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
224308010904	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
224308010905	Uncharacterized conserved protein [Function unknown]; Region: COG1284
224308010906	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308010907	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308010908	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
224308010909	peptide chain release factor 2; Validated; Region: prfB; PRK00578
224308010910	This domain is found in peptide chain release factors; Region: PCRF; smart00937
224308010911	RF-1 domain; Region: RF-1; pfam00472
224308010912	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
224308010913	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
224308010914	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
224308010915	nucleotide binding region [chemical binding]; other site
224308010916	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
224308010917	ATP-binding site [chemical binding]; other site
224308010918	SEC-C motif; Region: SEC-C; pfam02810
224308010919	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
224308010920	30S subunit binding site; other site
224308010921	Flagellar protein FliT; Region: FliT; pfam05400
224308010922	flagellar biosynthetic protein FliS; Region: fliS; TIGR00208
224308010923	flagellar capping protein; Validated; Region: fliD; PRK07737
224308010924	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
224308010925	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
224308010926	flagellar protein FlaG; Provisional; Region: PRK07738
224308010927	flagellin; Provisional; Region: PRK12804
224308010928	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
224308010929	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
224308010930	carbon storage regulator; Provisional; Region: PRK01712
224308010931	flagellar assembly protein FliW; Provisional; Region: PRK13285
224308010932	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
224308010933	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
224308010934	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
224308010935	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
224308010936	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224308010937	FlgN protein; Region: FlgN; pfam05130
224308010938	Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747
224308010939	flagellar operon protein TIGR03826; Region: YvyF
224308010940	comF family protein; Region: comF; TIGR00201
224308010941	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308010942	active site
224308010943	Late competence development protein ComFB; Region: ComFB; pfam10719
224308010944	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
224308010945	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308010946	ATP binding site [chemical binding]; other site
224308010947	putative Mg++ binding site [ion binding]; other site
224308010948	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308010949	nucleotide binding region [chemical binding]; other site
224308010950	ATP-binding site [chemical binding]; other site
224308010951	EDD domain protein, DegV family; Region: DegV; TIGR00762
224308010952	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
224308010953	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308010954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308010955	active site
224308010956	phosphorylation site [posttranslational modification]
224308010957	intermolecular recognition site; other site
224308010958	dimerization interface [polypeptide binding]; other site
224308010959	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308010960	DNA binding residues [nucleotide binding]
224308010961	dimerization interface [polypeptide binding]; other site
224308010962	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
224308010963	Histidine kinase; Region: HisKA_3; pfam07730
224308010964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308010965	ATP binding site [chemical binding]; other site
224308010966	Mg2+ binding site [ion binding]; other site
224308010967	G-X-G motif; other site
224308010968	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
224308010969	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
224308010970	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
224308010971	Transcriptional regulator [Transcription]; Region: LytR; COG1316
224308010972	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
224308010973	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
224308010974	Mg++ binding site [ion binding]; other site
224308010975	putative catalytic motif [active]
224308010976	substrate binding site [chemical binding]; other site
224308010977	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
224308010978	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224308010979	putative homodimer interface [polypeptide binding]; other site
224308010980	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224308010981	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308010982	active site
224308010983	Chain length determinant protein; Region: Wzz; pfam02706
224308010984	Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297
224308010985	O-Antigen ligase; Region: Wzy_C; pfam04932
224308010986	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
224308010987	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
224308010988	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
224308010989	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
224308010990	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224308010991	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
224308010992	colanic acid exporter; Provisional; Region: PRK10459
224308010993	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
224308010994	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId: 7704262; Product type pf :  factor
224308010995	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId: 10048024, 11994144; Product type pe: enzyme
224308010996	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
224308010997	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
224308010998	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
224308010999	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
224308011000	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
224308011001	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
224308011002	active site
224308011003	metal binding site [ion binding]; metal-binding site
224308011004	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
224308011005	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
224308011006	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
224308011007	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
224308011008	Stage II sporulation protein; Region: SpoIID; pfam08486
224308011009	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
224308011010	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
224308011011	membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379
224308011012	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
224308011013	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
224308011014	active site
224308011015	homodimer interface [polypeptide binding]; other site
224308011016	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
224308011017	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
224308011018	active site
224308011019	tetramer interface; other site
224308011020	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId: 7704262; Product type pe :  enzyme
224308011021	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308011022	active site
224308011023	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
224308011024	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
224308011025	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224308011026	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308011027	active site
224308011028	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId: 7704262; Product type pe :  enzyme
224308011029	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe:  enzyme
224308011030	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
224308011031	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
224308011032	Walker A/P-loop; other site
224308011033	ATP binding site [chemical binding]; other site
224308011034	Q-loop/lid; other site
224308011035	ABC transporter signature motif; other site
224308011036	Walker B; other site
224308011037	D-loop; other site
224308011038	H-loop/switch region; other site
224308011039	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
224308011040	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
224308011041	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
224308011042	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
224308011043	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
224308011044	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
224308011045	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224308011046	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
224308011047	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
224308011048	active site
224308011049	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
224308011050	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
224308011051	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
224308011052	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
224308011053	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
224308011054	Bacterial SH3 domain; Region: SH3_3; pfam08239
224308011055	Lysozyme subfamily 2; Region: LYZ2; smart00047
224308011056	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
224308011057	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
224308011058	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
224308011059	Spore germination protein; Region: Spore_permease; pfam03845
224308011060	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
224308011061	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
224308011062	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
224308011063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011064	putative substrate translocation pore; other site
224308011065	Transcriptional regulator [Transcription]; Region: LytR; COG1316
224308011066	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308011067	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
224308011068	active site
224308011069	motif I; other site
224308011070	motif II; other site
224308011071	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
224308011072	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
224308011073	NlpC/P60 family; Region: NLPC_P60; pfam00877
224308011074	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
224308011075	NlpC/P60 family; Region: NLPC_P60; pfam00877
224308011076	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
224308011077	NlpC/P60 family; Region: NLPC_P60; pfam00877
224308011078	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
224308011079	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
224308011080	putative active site [active]
224308011081	putative metal binding site [ion binding]; other site
224308011082	poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011
224308011083	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
224308011084	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224308011085	Transcriptional regulators [Transcription]; Region: PurR; COG1609
224308011086	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308011087	DNA binding site [nucleotide binding]
224308011088	domain linker motif; other site
224308011089	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
224308011090	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224308011091	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
224308011092	substrate binding site [chemical binding]; other site
224308011093	dimer interface [polypeptide binding]; other site
224308011094	ATP binding site [chemical binding]; other site
224308011095	D-ribose pyranase; Provisional; Region: PRK11797
224308011096	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
224308011097	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
224308011098	Walker A/P-loop; other site
224308011099	ATP binding site [chemical binding]; other site
224308011100	Q-loop/lid; other site
224308011101	ABC transporter signature motif; other site
224308011102	Walker B; other site
224308011103	D-loop; other site
224308011104	H-loop/switch region; other site
224308011105	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
224308011106	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
224308011107	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
224308011108	TM-ABC transporter signature motif; other site
224308011109	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
224308011110	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
224308011111	ligand binding site [chemical binding]; other site
224308011112	dimerization interface [polypeptide binding]; other site
224308011113	Bacterial SH3 domain homologues; Region: SH3b; smart00287
224308011114	Bacterial SH3 domain homologues; Region: SH3b; smart00287
224308011115	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
224308011116	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
224308011117	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
224308011118	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
224308011119	acetolactate synthase; Reviewed; Region: PRK08617
224308011120	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
224308011121	PYR/PP interface [polypeptide binding]; other site
224308011122	dimer interface [polypeptide binding]; other site
224308011123	TPP binding site [chemical binding]; other site
224308011124	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
224308011125	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
224308011126	TPP-binding site [chemical binding]; other site
224308011127	dimer interface [polypeptide binding]; other site
224308011128	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
224308011129	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308011130	The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452
224308011131	putative dimerization interface [polypeptide binding]; other site
224308011132	putative substrate binding pocket [chemical binding]; other site
224308011133	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
224308011134	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
224308011135	transmembrane helices; other site
224308011136	CotH protein; Region: CotH; pfam08757
224308011137	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
224308011138	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
224308011139	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
224308011140	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
224308011141	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
224308011142	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308011143	putative DNA binding site [nucleotide binding]; other site
224308011144	putative Zn2+ binding site [ion binding]; other site
224308011145	AsnC family; Region: AsnC_trans_reg; pfam01037
224308011146	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
224308011147	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
224308011148	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
224308011149	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
224308011150	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308011151	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308011152	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308011153	dimerization interface [polypeptide binding]; other site
224308011154	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
224308011155	Active_site [active]
224308011156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
224308011157	Uncharacterized conserved protein [Function unknown]; Region: COG5444
224308011158	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
224308011159	YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431
224308011160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
224308011161	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
224308011162	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
224308011163	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
224308011164	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
224308011165	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
224308011166	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
224308011167	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
224308011168	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
224308011169	Chain length determinant protein; Region: Wzz; cl15801
224308011170	SWIM zinc finger; Region: SWIM; pfam04434
224308011171	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
224308011172	SNF2 Helicase protein; Region: DUF3670; pfam12419
224308011173	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224308011174	ATP binding site [chemical binding]; other site
224308011175	putative Mg++ binding site [ion binding]; other site
224308011176	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308011177	nucleotide binding region [chemical binding]; other site
224308011178	ATP-binding site [chemical binding]; other site
224308011179	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308011180	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
224308011181	active site
224308011182	motif I; other site
224308011183	motif II; other site
224308011184	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308011185	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224308011186	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
224308011187	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
224308011188	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
224308011189	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
224308011190	dimer interface [polypeptide binding]; other site
224308011191	ssDNA binding site [nucleotide binding]; other site
224308011192	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224308011193	YwpF-like protein; Region: YwpF; pfam14183
224308011194	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
224308011195	active site
224308011196	catalytic site [active]
224308011197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308011198	active site
224308011199	dimerization interface [polypeptide binding]; other site
224308011200	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
224308011201	Histidine kinase; Region: His_kinase; pfam06580
224308011202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308011203	ATP binding site [chemical binding]; other site
224308011204	Mg2+ binding site [ion binding]; other site
224308011205	G-X-G motif; other site
224308011206	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955
224308011207	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
224308011208	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
224308011209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308011210	binding surface
224308011211	TPR motif; other site
224308011212	Tetratricopeptide repeat; Region: TPR_16; pfam13432
224308011213	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
224308011214	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
224308011215	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
224308011216	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
224308011217	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224308011218	rod shape-determining protein Mbl; Provisional; Region: PRK13928
224308011219	MreB and similar proteins; Region: MreB_like; cd10225
224308011220	nucleotide binding site [chemical binding]; other site
224308011221	Mg binding site [ion binding]; other site
224308011222	putative protofilament interaction site [polypeptide binding]; other site
224308011223	RodZ interaction site [polypeptide binding]; other site
224308011224	Stage III sporulation protein D; Region: SpoIIID; pfam12116
224308011225	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308011226	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308011227	putative Zn2+ binding site [ion binding]; other site
224308011228	putative DNA binding site [nucleotide binding]; other site
224308011229	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308011230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011231	putative substrate translocation pore; other site
224308011232	Right handed beta helix region; Region: Beta_helix; pfam13229
224308011233	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
224308011234	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
224308011235	Na binding site [ion binding]; other site
224308011236	putative substrate binding site [chemical binding]; other site
224308011237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011238	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308011239	putative substrate translocation pore; other site
224308011240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011241	Isochorismatase family; Region: Isochorismatase; pfam00857
224308011242	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
224308011243	catalytic triad [active]
224308011244	conserved cis-peptide bond; other site
224308011245	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
224308011246	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
224308011247	Nitrogen regulatory protein P-II; Region: P-II; smart00938
224308011248	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
224308011249	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
224308011250	active site
224308011251	VanZ like family; Region: VanZ; pfam04892
224308011252	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
224308011253	Peptidase family M23; Region: Peptidase_M23; pfam01551
224308011254	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
224308011255	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308011256	Coenzyme A binding pocket [chemical binding]; other site
224308011257	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
224308011258	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
224308011259	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
224308011260	putative active site [active]
224308011261	catalytic site [active]
224308011262	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
224308011263	putative active site [active]
224308011264	catalytic site [active]
224308011265	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
224308011266	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
224308011267	DNA binding residues [nucleotide binding]
224308011268	dimer interface [polypeptide binding]; other site
224308011269	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
224308011270	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
224308011271	NADH(P)-binding; Region: NAD_binding_10; pfam13460
224308011272	NAD binding site [chemical binding]; other site
224308011273	substrate binding site [chemical binding]; other site
224308011274	putative active site [active]
224308011275	Predicted transcriptional regulator [Transcription]; Region: COG1959
224308011276	Transcriptional regulator; Region: Rrf2; pfam02082
224308011277	urease subunit alpha; Reviewed; Region: ureC; PRK13207
224308011278	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
224308011279	subunit interactions [polypeptide binding]; other site
224308011280	active site
224308011281	flap region; other site
224308011282	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
224308011283	gamma-beta subunit interface [polypeptide binding]; other site
224308011284	alpha-beta subunit interface [polypeptide binding]; other site
224308011285	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
224308011286	alpha-gamma subunit interface [polypeptide binding]; other site
224308011287	beta-gamma subunit interface [polypeptide binding]; other site
224308011288	Evidence 4: Homologs of previously reported genes of unknown function
224308011289	Evidence 4: Homologs of previously reported genes of unknown function
224308011290	CsbD-like; Region: CsbD; pfam05532
224308011291	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308011292	binding surface
224308011293	TPR motif; other site
224308011294	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308011295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308011296	binding surface
224308011297	TPR motif; other site
224308011298	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
224308011299	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308011300	FeS/SAM binding site; other site
224308011301	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
224308011302	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
224308011303	VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456
224308011304	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
224308011305	metal ion-dependent adhesion site (MIDAS); other site
224308011306	VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456
224308011307	metal ion-dependent adhesion site (MIDAS); other site
224308011308	stage II sporulation protein D; Region: spore_II_D; TIGR02870
224308011309	Stage II sporulation protein; Region: SpoIID; pfam08486
224308011310	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
224308011311	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
224308011312	hinge; other site
224308011313	active site
224308011314	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
224308011315	Predicted membrane protein [Function unknown]; Region: COG4836
224308011316	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
224308011317	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
224308011318	gamma subunit interface [polypeptide binding]; other site
224308011319	epsilon subunit interface [polypeptide binding]; other site
224308011320	LBP interface [polypeptide binding]; other site
224308011321	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
224308011322	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
224308011323	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
224308011324	alpha subunit interaction interface [polypeptide binding]; other site
224308011325	Walker A motif; other site
224308011326	ATP binding site [chemical binding]; other site
224308011327	Walker B motif; other site
224308011328	inhibitor binding site; inhibition site
224308011329	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
224308011330	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
224308011331	core domain interface [polypeptide binding]; other site
224308011332	delta subunit interface [polypeptide binding]; other site
224308011333	epsilon subunit interface [polypeptide binding]; other site
224308011334	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
224308011335	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
224308011336	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
224308011337	beta subunit interaction interface [polypeptide binding]; other site
224308011338	Walker A motif; other site
224308011339	ATP binding site [chemical binding]; other site
224308011340	Walker B motif; other site
224308011341	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
224308011342	ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145
224308011343	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
224308011344	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
224308011345	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
224308011346	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
224308011347	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
224308011348	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
224308011349	ATP synthase I chain; Region: ATP_synt_I; pfam03899
224308011350	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224308011351	active site
224308011352	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
224308011353	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
224308011354	dimer interface [polypeptide binding]; other site
224308011355	active site
224308011356	glycine-pyridoxal phosphate binding site [chemical binding]; other site
224308011357	folate binding site [chemical binding]; other site
224308011358	hypothetical protein; Provisional; Region: PRK13690
224308011359	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
224308011360	Low molecular weight phosphatase family; Region: LMWPc; cd00115
224308011361	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
224308011362	active site
224308011363	Predicted membrane protein [Function unknown]; Region: COG1971
224308011364	Domain of unknown function DUF; Region: DUF204; pfam02659
224308011365	Domain of unknown function DUF; Region: DUF204; pfam02659
224308011366	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
224308011367	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
224308011368	N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246
224308011369	stage II sporulation protein R; Region: spore_II_R; TIGR02837
224308011370	HemK family putative methylases; Region: hemK_fam; TIGR00536
224308011371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308011372	S-adenosylmethionine binding site [chemical binding]; other site
224308011373	peptide chain release factor 1; Validated; Region: prfA; PRK00591
224308011374	This domain is found in peptide chain release factors; Region: PCRF; smart00937
224308011375	RF-1 domain; Region: RF-1; pfam00472
224308011376	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
224308011377	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308011378	putative metal binding site [ion binding]; other site
224308011379	polar chromosome segregation protein; Reviewed; Region: racA; PRK13182
224308011380	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
224308011381	DNA binding residues [nucleotide binding]
224308011382	he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946
224308011383	malate dehydrogenase; Provisional; Region: PRK13529
224308011384	Malic enzyme, N-terminal domain; Region: malic; pfam00390
224308011385	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
224308011386	NAD(P) binding site [chemical binding]; other site
224308011387	thymidine kinase; Provisional; Region: PRK04296
224308011388	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
224308011389	transcription termination factor Rho; Provisional; Region: rho; PRK09376
224308011390	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
224308011391	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
224308011392	RNA binding site [nucleotide binding]; other site
224308011393	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
224308011394	multimer interface [polypeptide binding]; other site
224308011395	Walker A motif; other site
224308011396	ATP binding site [chemical binding]; other site
224308011397	Walker B motif; other site
224308011398	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
224308011399	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
224308011400	putative active site [active]
224308011401	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
224308011402	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
224308011403	hinge; other site
224308011404	active site
224308011405	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
224308011406	active site
224308011407	intersubunit interactions; other site
224308011408	catalytic residue [active]
224308011409	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
224308011410	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
224308011411	intersubunit interface [polypeptide binding]; other site
224308011412	active site
224308011413	zinc binding site [ion binding]; other site
224308011414	Na+ binding site [ion binding]; other site
224308011415	Response regulator receiver domain; Region: Response_reg; pfam00072
224308011416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308011417	active site
224308011418	phosphorylation site [posttranslational modification]
224308011419	intermolecular recognition site; other site
224308011420	dimerization interface [polypeptide binding]; other site
224308011421	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
224308011422	CTP synthetase; Validated; Region: pyrG; PRK05380
224308011423	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
224308011424	Catalytic site [active]
224308011425	active site
224308011426	UTP binding site [chemical binding]; other site
224308011427	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
224308011428	active site
224308011429	putative oxyanion hole; other site
224308011430	catalytic triad [active]
224308011431	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
224308011432	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
224308011433	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
224308011434	FAD binding site [chemical binding]; other site
224308011435	homotetramer interface [polypeptide binding]; other site
224308011436	substrate binding pocket [chemical binding]; other site
224308011437	catalytic base [active]
224308011438	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
224308011439	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
224308011440	Cysteine-rich domain; Region: CCG; pfam02754
224308011441	Cysteine-rich domain; Region: CCG; pfam02754
224308011442	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
224308011443	putative active site [active]
224308011444	catalytic site [active]
224308011445	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
224308011446	PLD-like domain; Region: PLDc_2; pfam13091
224308011447	putative active site [active]
224308011448	catalytic site [active]
224308011449	UV damage endonuclease UvdE; Region: uvde; TIGR00629
224308011450	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
224308011451	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
224308011452	folate binding site [chemical binding]; other site
224308011453	NADP+ binding site [chemical binding]; other site
224308011454	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224308011455	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308011456	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
224308011457	Walker A/P-loop; other site
224308011458	ATP binding site [chemical binding]; other site
224308011459	Q-loop/lid; other site
224308011460	ABC transporter signature motif; other site
224308011461	Walker B; other site
224308011462	D-loop; other site
224308011463	H-loop/switch region; other site
224308011464	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
224308011465	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
224308011466	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
224308011467	putative active site [active]
224308011468	catalytic site [active]
224308011469	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
224308011470	putative active site [active]
224308011471	catalytic site [active]
224308011472	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
224308011473	nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684
224308011474	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
224308011475	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
224308011476	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
224308011477	[4Fe-4S] binding site [ion binding]; other site
224308011478	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
224308011479	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
224308011480	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
224308011481	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
224308011482	molybdopterin cofactor binding site; other site
224308011483	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
224308011484	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
224308011485	ligand binding site [chemical binding]; other site
224308011486	flexible hinge region; other site
224308011487	YwiC-like protein; Region: YwiC; pfam14256
224308011488	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
224308011489	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
224308011490	ligand binding site [chemical binding]; other site
224308011491	flexible hinge region; other site
224308011492	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
224308011493	putative switch regulator; other site
224308011494	non-specific DNA interactions [nucleotide binding]; other site
224308011495	DNA binding site [nucleotide binding]
224308011496	sequence specific DNA binding site [nucleotide binding]; other site
224308011497	putative cAMP binding site [chemical binding]; other site
224308011498	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
224308011499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011500	putative substrate translocation pore; other site
224308011501	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
224308011502	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
224308011503	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
224308011504	active site
224308011505	HIGH motif; other site
224308011506	KMSK motif region; other site
224308011507	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
224308011508	tRNA binding surface [nucleotide binding]; other site
224308011509	anticodon binding site; other site
224308011510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
224308011511	Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420
224308011512	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
224308011513	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
224308011514	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308011515	FeS/SAM binding site; other site
224308011516	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
224308011517	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
224308011518	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
224308011519	Walker A/P-loop; other site
224308011520	ATP binding site [chemical binding]; other site
224308011521	Q-loop/lid; other site
224308011522	ABC transporter signature motif; other site
224308011523	Walker B; other site
224308011524	D-loop; other site
224308011525	H-loop/switch region; other site
224308011526	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224308011527	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
224308011528	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224308011529	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
224308011530	Uncharacterized conserved protein [Function unknown]; Region: COG3391
224308011531	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
224308011532	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
224308011533	Uncharacterized conserved protein [Function unknown]; Region: COG3391
224308011534	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
224308011535	binding surface
224308011536	TPR motif; other site
224308011537	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
224308011538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308011539	TPR motif; other site
224308011540	binding surface
224308011541	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308011542	Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131
224308011543	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
224308011544	putative deacylase active site [active]
224308011545	agmatinase; Region: agmatinase; TIGR01230
224308011546	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
224308011547	putative active site [active]
224308011548	Mn binding site [ion binding]; other site
224308011549	spermidine synthase; Provisional; Region: PRK00811
224308011550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308011551	Transglycosylase; Region: Transgly; pfam00912
224308011552	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
224308011553	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
224308011554	YwhD family; Region: YwhD; pfam08741
224308011555	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
224308011556	Peptidase family M50; Region: Peptidase_M50; pfam02163
224308011557	active site
224308011558	putative substrate binding region [chemical binding]; other site
224308011559	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
224308011560	active site 1 [active]
224308011561	dimer interface [polypeptide binding]; other site
224308011562	hexamer interface [polypeptide binding]; other site
224308011563	active site 2 [active]
224308011564	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308011565	MarR family; Region: MarR; pfam01047
224308011566	MarR family; Region: MarR_2; cl17246
224308011567	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
224308011568	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
224308011569	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
224308011570	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
224308011571	active site
224308011572	dimer interface [polypeptide binding]; other site
224308011573	motif 1; other site
224308011574	motif 2; other site
224308011575	motif 3; other site
224308011576	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
224308011577	anticodon binding site; other site
224308011578	benzoate transport; Region: 2A0115; TIGR00895
224308011579	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011580	putative substrate translocation pore; other site
224308011581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011582	Rrf2 family protein; Region: rrf2_super; TIGR00738
224308011583	Transcriptional regulator; Region: Rrf2; pfam02082
224308011584	Uncharacterized conserved protein [Function unknown]; Region: COG3465
224308011585	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
224308011586	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224308011587	Zn2+ binding site [ion binding]; other site
224308011588	Mg2+ binding site [ion binding]; other site
224308011589	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
224308011590	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
224308011591	EamA-like transporter family; Region: EamA; pfam00892
224308011592	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
224308011593	EamA-like transporter family; Region: EamA; pfam00892
224308011594	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
224308011595	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308011596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308011597	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
224308011598	putative dimerization interface [polypeptide binding]; other site
224308011599	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
224308011600	putative heme peroxidase; Provisional; Region: PRK12276
224308011601	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224308011602	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
224308011603	putative NAD(P) binding site [chemical binding]; other site
224308011604	putative active site [active]
224308011605	transaminase; Reviewed; Region: PRK08068
224308011606	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224308011607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308011608	homodimer interface [polypeptide binding]; other site
224308011609	catalytic residue [active]
224308011610	H+ Antiporter protein; Region: 2A0121; TIGR00900
224308011611	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
224308011612	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
224308011613	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
224308011614	classical (c) SDRs; Region: SDR_c; cd05233
224308011615	NAD(P) binding site [chemical binding]; other site
224308011616	active site
224308011617	Cupin domain; Region: Cupin_2; pfam07883
224308011618	Cupin domain; Region: Cupin_2; pfam07883
224308011619	Prephenate dehydratase; Region: PDT; pfam00800
224308011620	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224308011621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011622	putative substrate translocation pore; other site
224308011623	S-methylmethionine transporter; Provisional; Region: PRK11387
224308011624	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
224308011625	putative metal binding site [ion binding]; other site
224308011626	putative dimer interface [polypeptide binding]; other site
224308011627	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
224308011628	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
224308011629	Glutamate binding site [chemical binding]; other site
224308011630	homodimer interface [polypeptide binding]; other site
224308011631	NAD binding site [chemical binding]; other site
224308011632	catalytic residues [active]
224308011633	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
224308011634	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
224308011635	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
224308011636	NAD(P) binding site [chemical binding]; other site
224308011637	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
224308011638	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
224308011639	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
224308011640	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
224308011641	NADP binding site [chemical binding]; other site
224308011642	active site
224308011643	putative substrate binding site [chemical binding]; other site
224308011644	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
224308011645	dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181
224308011646	NAD binding site [chemical binding]; other site
224308011647	substrate binding site [chemical binding]; other site
224308011648	homodimer interface [polypeptide binding]; other site
224308011649	active site
224308011650	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
224308011651	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
224308011652	substrate binding site; other site
224308011653	tetramer interface; other site
224308011654	Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980
224308011655	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
224308011656	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
224308011657	ligand binding site; other site
224308011658	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
224308011659	NeuB family; Region: NeuB; pfam03102
224308011660	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
224308011661	NeuB binding interface [polypeptide binding]; other site
224308011662	putative substrate binding site [chemical binding]; other site
224308011663	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
224308011664	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308011665	Coenzyme A binding pocket [chemical binding]; other site
224308011666	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
224308011667	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
224308011668	inhibitor-cofactor binding pocket; inhibition site
224308011669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308011670	catalytic residue [active]
224308011671	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
224308011672	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
224308011673	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224308011674	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308011675	active site
224308011676	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
224308011677	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
224308011678	Permease family; Region: Xan_ur_permease; pfam00860
224308011679	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
224308011680	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
224308011681	NAD(P) binding site [chemical binding]; other site
224308011682	catalytic residues [active]
224308011683	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
224308011684	ligand binding site [chemical binding]; other site
224308011685	active site
224308011686	UGI interface [polypeptide binding]; other site
224308011687	catalytic site [active]
224308011688	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224308011689	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
224308011690	active site
224308011691	Predicted transcriptional regulators [Transcription]; Region: COG1695
224308011692	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224308011693	putative DNA binding site [nucleotide binding]; other site
224308011694	putative Zn2+ binding site [ion binding]; other site
224308011695	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
224308011696	dimer interface [polypeptide binding]; other site
224308011697	substrate binding site [chemical binding]; other site
224308011698	ATP binding site [chemical binding]; other site
224308011699	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
224308011700	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
224308011701	substrate binding [chemical binding]; other site
224308011702	active site
224308011703	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
224308011704	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
224308011705	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224308011706	active site turn [active]
224308011707	phosphorylation site [posttranslational modification]
224308011708	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
224308011709	formate/nitrite transporter; Region: fnt; TIGR00790
224308011710	transcriptional antiterminator BglG; Provisional; Region: PRK09772
224308011711	CAT RNA binding domain; Region: CAT_RBD; smart01061
224308011712	PRD domain; Region: PRD; pfam00874
224308011713	PRD domain; Region: PRD; pfam00874
224308011714	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
224308011715	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
224308011716	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
224308011717	putative active site [active]
224308011718	catalytic triad [active]
224308011719	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
224308011720	PA/protease domain interface [polypeptide binding]; other site
224308011721	putative integrin binding motif; other site
224308011722	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
224308011723	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
224308011724	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
224308011725	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
224308011726	Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171
224308011727	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
224308011728	dimer interface [polypeptide binding]; other site
224308011729	FMN binding site [chemical binding]; other site
224308011730	NADPH bind site [chemical binding]; other site
224308011731	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
224308011732	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
224308011733	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
224308011734	Subunit I/III interface [polypeptide binding]; other site
224308011735	Subunit III/IV interface [polypeptide binding]; other site
224308011736	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
224308011737	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
224308011738	D-pathway; other site
224308011739	Putative ubiquinol binding site [chemical binding]; other site
224308011740	Low-spin heme (heme b) binding site [chemical binding]; other site
224308011741	Putative water exit pathway; other site
224308011742	Binuclear center (heme o3/CuB) [ion binding]; other site
224308011743	K-pathway; other site
224308011744	Putative proton exit pathway; other site
224308011745	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
224308011746	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
224308011747	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
224308011748	Predicted membrane protein [Function unknown]; Region: COG2261
224308011749	Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468
224308011750	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
224308011751	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
224308011752	galactokinase; Provisional; Region: PRK05322
224308011753	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
224308011754	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
224308011755	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
224308011756	Predicted membrane protein [Function unknown]; Region: COG2246
224308011757	GtrA-like protein; Region: GtrA; pfam04138
224308011758	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308011759	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308011760	Anti-repressor SinI; Region: SinI; pfam08671
224308011761	Predicted membrane protein [Function unknown]; Region: COG3162
224308011762	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
224308011763	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
224308011764	Na binding site [ion binding]; other site
224308011765	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
224308011766	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
224308011767	catalytic residues [active]
224308011768	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
224308011769	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
224308011770	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
224308011771	Imelysin; Region: Peptidase_M75; pfam09375
224308011772	FTR1 family protein; Region: TIGR00145
224308011773	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
224308011774	thiamine phosphate binding site [chemical binding]; other site
224308011775	active site
224308011776	pyrophosphate binding site [ion binding]; other site
224308011777	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
224308011778	substrate binding site [chemical binding]; other site
224308011779	multimerization interface [polypeptide binding]; other site
224308011780	ATP binding site [chemical binding]; other site
224308011781	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308011782	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308011783	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
224308011784	putative dimerization interface [polypeptide binding]; other site
224308011785	holin-like protein; Validated; Region: PRK01658
224308011786	TIGR00659 family protein; Region: TIGR00659
224308011787	sugar efflux transporter; Region: 2A0120; TIGR00899
224308011788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011789	putative substrate translocation pore; other site
224308011790	conserved hypothetical protein; Region: TIGR03833
224308011791	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
224308011792	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
224308011793	putative RNA binding site [nucleotide binding]; other site
224308011794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308011795	S-adenosylmethionine binding site [chemical binding]; other site
224308011796	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308011797	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
224308011798	active site
224308011799	metal binding site [ion binding]; metal-binding site
224308011800	Protein of unknown function (DUF2711); Region: DUF2711; pfam10924
224308011801	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
224308011802	PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410
224308011803	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
224308011804	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
224308011805	active site
224308011806	catalytic residues [active]
224308011807	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
224308011808	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224308011809	active site turn [active]
224308011810	phosphorylation site [posttranslational modification]
224308011811	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
224308011812	transcriptional antiterminator BglG; Provisional; Region: PRK09772
224308011813	CAT RNA binding domain; Region: CAT_RBD; pfam03123
224308011814	PRD domain; Region: PRD; pfam00874
224308011815	PRD domain; Region: PRD; pfam00874
224308011816	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
224308011817	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
224308011818	Ligand binding site; other site
224308011819	metal-binding site
224308011820	Predicted integral membrane protein [Function unknown]; Region: COG5522
224308011821	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308011822	MarR family; Region: MarR; pfam01047
224308011823	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
224308011824	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
224308011825	active site
224308011826	HIGH motif; other site
224308011827	dimer interface [polypeptide binding]; other site
224308011828	KMSKS motif; other site
224308011829	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224308011830	RNA binding surface [nucleotide binding]; other site
224308011831	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
224308011832	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
224308011833	PA/protease domain interface [polypeptide binding]; other site
224308011834	putative integrin binding motif; other site
224308011835	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
224308011836	Peptidase family M28; Region: Peptidase_M28; pfam04389
224308011837	metal binding site [ion binding]; metal-binding site
224308011838	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
224308011839	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
224308011840	synthetase active site [active]
224308011841	NTP binding site [chemical binding]; other site
224308011842	metal binding site [ion binding]; metal-binding site
224308011843	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
224308011844	UbiA prenyltransferase family; Region: UbiA; pfam01040
224308011845	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
224308011846	D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734
224308011847	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
224308011848	acyl-activating enzyme (AAE) consensus motif; other site
224308011849	AMP binding site [chemical binding]; other site
224308011850	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
224308011851	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
224308011852	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
224308011853	DltD N-terminal region; Region: DltD_N; pfam04915
224308011854	DltD central region; Region: DltD_M; pfam04918
224308011855	DltD C-terminal region; Region: DltD_C; pfam04914
224308011856	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
224308011857	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
224308011858	putative NAD(P) binding site [chemical binding]; other site
224308011859	active site
224308011860	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
224308011861	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
224308011862	homodimer interface [polypeptide binding]; other site
224308011863	substrate-cofactor binding pocket; other site
224308011864	catalytic residue [active]
224308011865	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
224308011866	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
224308011867	NAD binding site [chemical binding]; other site
224308011868	sugar binding site [chemical binding]; other site
224308011869	divalent metal binding site [ion binding]; other site
224308011870	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224308011871	dimer interface [polypeptide binding]; other site
224308011872	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
224308011873	methionine cluster; other site
224308011874	active site
224308011875	phosphorylation site [posttranslational modification]
224308011876	metal binding site [ion binding]; metal-binding site
224308011877	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
224308011878	PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410
224308011879	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
224308011880	active site
224308011881	P-loop; other site
224308011882	phosphorylation site [posttranslational modification]
224308011883	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
224308011884	HTH domain; Region: HTH_11; pfam08279
224308011885	Mga helix-turn-helix domain; Region: Mga; pfam05043
224308011886	PRD domain; Region: PRD; pfam00874
224308011887	PRD domain; Region: PRD; pfam00874
224308011888	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
224308011889	active site
224308011890	P-loop; other site
224308011891	phosphorylation site [posttranslational modification]
224308011892	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
224308011893	active site
224308011894	phosphorylation site [posttranslational modification]
224308011895	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
224308011896	active site
224308011897	DNA binding site [nucleotide binding]
224308011898	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
224308011899	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
224308011900	tetramer interface [polypeptide binding]; other site
224308011901	heme binding pocket [chemical binding]; other site
224308011902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308011903	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308011904	putative substrate translocation pore; other site
224308011905	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
224308011906	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
224308011907	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
224308011908	Walker A/P-loop; other site
224308011909	ATP binding site [chemical binding]; other site
224308011910	Q-loop/lid; other site
224308011911	ABC transporter signature motif; other site
224308011912	Walker B; other site
224308011913	D-loop; other site
224308011914	H-loop/switch region; other site
224308011915	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
224308011916	Exoribonuclease II [Transcription]; Region: Rnb; COG4776
224308011917	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
224308011918	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224308011919	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308011920	DNA binding residues [nucleotide binding]
224308011921	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
224308011922	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
224308011923	Na binding site [ion binding]; other site
224308011924	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
224308011925	putative substrate binding site [chemical binding]; other site
224308011926	putative ATP binding site [chemical binding]; other site
224308011927	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
224308011928	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308011929	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
224308011930	Walker A/P-loop; other site
224308011931	ATP binding site [chemical binding]; other site
224308011932	Q-loop/lid; other site
224308011933	ABC transporter signature motif; other site
224308011934	Walker B; other site
224308011935	D-loop; other site
224308011936	H-loop/switch region; other site
224308011937	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
224308011938	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224308011939	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224308011940	ATP binding site [chemical binding]; other site
224308011941	Q-loop/lid; other site
224308011942	ABC transporter signature motif; other site
224308011943	Walker B; other site
224308011944	D-loop; other site
224308011945	H-loop/switch region; other site
224308011946	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
224308011947	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
224308011948	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
224308011949	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
224308011950	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
224308011951	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
224308011952	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
224308011953	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
224308011954	putative active site [active]
224308011955	putative metal binding site [ion binding]; other site
224308011956	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
224308011957	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
224308011958	Walker A/P-loop; other site
224308011959	ATP binding site [chemical binding]; other site
224308011960	Q-loop/lid; other site
224308011961	ABC transporter signature motif; other site
224308011962	Walker B; other site
224308011963	D-loop; other site
224308011964	H-loop/switch region; other site
224308011965	TOBE domain; Region: TOBE; pfam03459
224308011966	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
224308011967	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
224308011968	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
224308011969	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224308011970	NAD(P) binding site [chemical binding]; other site
224308011971	catalytic residues [active]
224308011972	Uncharacterized conserved protein [Function unknown]; Region: COG1284
224308011973	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308011974	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
224308011975	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
224308011976	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
224308011977	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
224308011978	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
224308011979	UDP-glucose 4-epimerase; Region: PLN02240
224308011980	NAD binding site [chemical binding]; other site
224308011981	homodimer interface [polypeptide binding]; other site
224308011982	active site
224308011983	substrate binding site [chemical binding]; other site
224308011984	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
224308011985	substrate binding site [chemical binding]; other site
224308011986	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308011987	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308011988	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
224308011989	dimerization interface [polypeptide binding]; other site
224308011990	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
224308011991	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
224308011992	Histidine kinase; Region: HisKA_3; pfam07730
224308011993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308011994	ATP binding site [chemical binding]; other site
224308011995	Mg2+ binding site [ion binding]; other site
224308011996	G-X-G motif; other site
224308011997	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
224308011998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308011999	active site
224308012000	phosphorylation site [posttranslational modification]
224308012001	intermolecular recognition site; other site
224308012002	dimerization interface [polypeptide binding]; other site
224308012003	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
224308012004	DNA binding residues [nucleotide binding]
224308012005	dimerization interface [polypeptide binding]; other site
224308012006	peptidase T; Region: peptidase-T; TIGR01882
224308012007	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
224308012008	metal binding site [ion binding]; metal-binding site
224308012009	dimer interface [polypeptide binding]; other site
224308012010	Uncharacterized conserved protein [Function unknown]; Region: COG4894
224308012011	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
224308012012	substrate binding site [chemical binding]; other site
224308012013	THF binding site; other site
224308012014	zinc-binding site [ion binding]; other site
224308012015	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
224308012016	substrate binding site [chemical binding]; other site
224308012017	THF binding site; other site
224308012018	zinc-binding site [ion binding]; other site
224308012019	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
224308012020	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
224308012021	NAD binding site [chemical binding]; other site
224308012022	homotetramer interface [polypeptide binding]; other site
224308012023	homodimer interface [polypeptide binding]; other site
224308012024	substrate binding site [chemical binding]; other site
224308012025	active site
224308012026	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
224308012027	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
224308012028	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
224308012029	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
224308012030	Methyltransferase domain; Region: Methyltransf_11; pfam08241
224308012031	S-adenosylmethionine binding site [chemical binding]; other site
224308012032	nucleoside transporter; Region: nupC; TIGR00804
224308012033	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
224308012034	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
224308012035	Evidence 7: Gene remnant
224308012036	Evidence 7: Gene remnant
224308012037	hydroperoxidase II; Provisional; Region: katE; PRK11249
224308012038	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
224308012039	tetramer interface [polypeptide binding]; other site
224308012040	heme binding pocket [chemical binding]; other site
224308012041	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
224308012042	domain interactions; other site
224308012043	citrate transporter, CitMHS family; Region: citMHS; TIGR00784
224308012044	Citrate transporter; Region: CitMHS; pfam03600
224308012045	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
224308012046	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
224308012047	active site
224308012048	active site
224308012049	catalytic residues [active]
224308012050	transcriptional antiterminator BglG; Provisional; Region: PRK09772
224308012051	CAT RNA binding domain; Region: CAT_RBD; pfam03123
224308012052	PRD domain; Region: PRD; pfam00874
224308012053	PRD domain; Region: PRD; pfam00874
224308012054	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
224308012055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012056	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
224308012057	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
224308012058	ATP binding site [chemical binding]; other site
224308012059	Mg++ binding site [ion binding]; other site
224308012060	motif III; other site
224308012061	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224308012062	nucleotide binding region [chemical binding]; other site
224308012063	ATP-binding site [chemical binding]; other site
224308012064	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
224308012065	RNA binding site [nucleotide binding]; other site
224308012066	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
224308012067	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
224308012068	active site
224308012069	catalytic triad [active]
224308012070	Evidence 5: No homology to any previously reported sequences
224308012071	YxiJ-like protein; Region: YxiJ; pfam14176
224308012072	Protein of unknown function (DUF2716); Region: DUF2716; pfam10898
224308012073	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224308012074	RHS Repeat; Region: RHS_repeat; pfam05593
224308012075	RHS Repeat; Region: RHS_repeat; pfam05593
224308012076	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
224308012077	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
224308012078	RHS Repeat; Region: RHS_repeat; pfam05593
224308012079	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
224308012080	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
224308012081	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
224308012082	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224308012083	EamA-like transporter family; Region: EamA; pfam00892
224308012084	EamA-like transporter family; Region: EamA; pfam00892
224308012085	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224308012086	Ligand Binding Site [chemical binding]; other site
224308012087	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
224308012088	beta-galactosidase; Region: BGL; TIGR03356
224308012089	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
224308012090	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
224308012091	active site turn [active]
224308012092	phosphorylation site [posttranslational modification]
224308012093	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
224308012094	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
224308012095	HPr interaction site; other site
224308012096	glycerol kinase (GK) interaction site [polypeptide binding]; other site
224308012097	active site
224308012098	phosphorylation site [posttranslational modification]
224308012099	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
224308012100	Uncharacterized conserved protein [Function unknown]; Region: COG5444
224308012101	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
224308012102	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
224308012103	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
224308012104	substrate binding site [chemical binding]; other site
224308012105	active site
224308012106	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
224308012107	hexamer interface [polypeptide binding]; other site
224308012108	RNA binding site [nucleotide binding]; other site
224308012109	Histidine-zinc binding site [chemical binding]; other site
224308012110	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
224308012111	active sites [active]
224308012112	tetramer interface [polypeptide binding]; other site
224308012113	urocanate hydratase; Provisional; Region: PRK05414
224308012114	imidazolonepropionase; Validated; Region: PRK09356
224308012115	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
224308012116	active site
224308012117	Agmatinase-like family; Region: Agmatinase-like; cd09990
224308012118	agmatinase; Region: agmatinase; TIGR01230
224308012119	active site
224308012120	oligomer interface [polypeptide binding]; other site
224308012121	Mn binding site [ion binding]; other site
224308012122	S-methylmethionine transporter; Provisional; Region: PRK11387
224308012123	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
224308012124	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
224308012125	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
224308012126	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
224308012127	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
224308012128	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
224308012129	Nucleoside recognition; Region: Gate; pfam07670
224308012130	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
224308012131	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
224308012132	intersubunit interface [polypeptide binding]; other site
224308012133	active site
224308012134	catalytic residue [active]
224308012135	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
224308012136	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224308012137	DNA binding residues [nucleotide binding]
224308012138	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
224308012139	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
224308012140	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
224308012141	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
224308012142	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
224308012143	MmgE/PrpD family; Region: MmgE_PrpD; pfam03972
224308012144	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
224308012145	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
224308012146	metal binding site [ion binding]; metal-binding site
224308012147	dimer interface [polypeptide binding]; other site
224308012148	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224308012149	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
224308012150	Walker A/P-loop; other site
224308012151	ATP binding site [chemical binding]; other site
224308012152	Q-loop/lid; other site
224308012153	ABC transporter signature motif; other site
224308012154	Walker B; other site
224308012155	D-loop; other site
224308012156	H-loop/switch region; other site
224308012157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224308012158	dimer interface [polypeptide binding]; other site
224308012159	conserved gate region; other site
224308012160	putative PBP binding loops; other site
224308012161	ABC-ATPase subunit interface; other site
224308012162	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
224308012163	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
224308012164	substrate binding pocket [chemical binding]; other site
224308012165	membrane-bound complex binding site; other site
224308012166	hinge residues; other site
224308012167	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308012168	Coenzyme A binding pocket [chemical binding]; other site
224308012169	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
224308012170	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
224308012171	active site
224308012172	non-prolyl cis peptide bond; other site
224308012173	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
224308012174	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
224308012175	active site
224308012176	sugar phosphate phosphatase; Provisional; Region: PRK10513
224308012177	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308012178	active site
224308012179	motif I; other site
224308012180	motif II; other site
224308012181	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224308012182	Protein of unknown function (DUF3255); Region: DUF3255; pfam11631
224308012183	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
224308012184	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
224308012185	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
224308012186	putative ligand binding residues [chemical binding]; other site
224308012187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
224308012188	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224308012189	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
224308012190	Walker A/P-loop; other site
224308012191	ATP binding site [chemical binding]; other site
224308012192	Q-loop/lid; other site
224308012193	ABC transporter signature motif; other site
224308012194	Walker B; other site
224308012195	D-loop; other site
224308012196	H-loop/switch region; other site
224308012197	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224308012198	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
224308012199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308012200	ATP binding site [chemical binding]; other site
224308012201	Mg2+ binding site [ion binding]; other site
224308012202	G-X-G motif; other site
224308012203	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308012204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308012205	active site
224308012206	phosphorylation site [posttranslational modification]
224308012207	intermolecular recognition site; other site
224308012208	dimerization interface [polypeptide binding]; other site
224308012209	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308012210	DNA binding site [nucleotide binding]
224308012211	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
224308012212	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
224308012213	intersubunit interface [polypeptide binding]; other site
224308012214	active site
224308012215	zinc binding site [ion binding]; other site
224308012216	Na+ binding site [ion binding]; other site
224308012217	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
224308012218	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
224308012219	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
224308012220	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
224308012221	DNA interaction; other site
224308012222	Metal-binding active site; metal-binding site
224308012223	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224308012224	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
224308012225	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
224308012226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012227	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308012228	putative substrate translocation pore; other site
224308012229	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
224308012230	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
224308012231	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
224308012232	PYR/PP interface [polypeptide binding]; other site
224308012233	dimer interface [polypeptide binding]; other site
224308012234	TPP binding site [chemical binding]; other site
224308012235	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
224308012236	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
224308012237	TPP-binding site; other site
224308012238	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
224308012239	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
224308012240	substrate binding site [chemical binding]; other site
224308012241	ATP binding site [chemical binding]; other site
224308012242	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
224308012243	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
224308012244	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
224308012245	tetrameric interface [polypeptide binding]; other site
224308012246	NAD binding site [chemical binding]; other site
224308012247	catalytic residues [active]
224308012248	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224308012249	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
224308012250	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
224308012251	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224308012252	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
224308012253	active site
224308012254	catalytic tetrad [active]
224308012255	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
224308012256	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
224308012257	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012258	putative substrate translocation pore; other site
224308012259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012260	heat shock protein 90; Provisional; Region: PRK05218
224308012261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308012262	ATP binding site [chemical binding]; other site
224308012263	Mg2+ binding site [ion binding]; other site
224308012264	G-X-G motif; other site
224308012265	short chain dehydrogenase; Validated; Region: PRK08589
224308012266	classical (c) SDRs; Region: SDR_c; cd05233
224308012267	NAD(P) binding site [chemical binding]; other site
224308012268	active site
224308012269	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308012270	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308012271	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308012272	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
224308012273	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
224308012274	NAD(P) binding site [chemical binding]; other site
224308012275	catalytic residues [active]
224308012276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308012277	Coenzyme A binding pocket [chemical binding]; other site
224308012278	Uncharacterized conserved protein [Function unknown]; Region: COG2850
224308012279	Cupin-like domain; Region: Cupin_8; pfam13621
224308012280	Methyltransferase domain; Region: Methyltransf_23; pfam13489
224308012281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308012282	S-adenosylmethionine binding site [chemical binding]; other site
224308012283	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
224308012284	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
224308012285	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
224308012286	active site
224308012287	dimer interface [polypeptide binding]; other site
224308012288	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
224308012289	Ligand Binding Site [chemical binding]; other site
224308012290	Molecular Tunnel; other site
224308012291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012292	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308012293	putative substrate translocation pore; other site
224308012294	FOG: WD40-like repeat [Function unknown]; Region: COG1520
224308012295	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
224308012296	active site
224308012297	Trp docking motif [polypeptide binding]; other site
224308012298	RDD family; Region: RDD; pfam06271
224308012299	Predicted membrane protein [Function unknown]; Region: COG2311
224308012300	Protein of unknown function (DUF418); Region: DUF418; pfam04235
224308012301	Cupin domain; Region: Cupin_2; pfam07883
224308012302	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
224308012303	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224308012304	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224308012305	short chain dehydrogenase; Provisional; Region: PRK07109
224308012306	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
224308012307	putative NAD(P) binding site [chemical binding]; other site
224308012308	active site
224308012309	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308012310	MarR family; Region: MarR; pfam01047
224308012311	LrgA family; Region: LrgA; cl00608
224308012312	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
224308012313	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
224308012314	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
224308012315	Glycerate kinase family; Region: Gly_kinase; pfam02595
224308012316	Transcriptional regulators [Transcription]; Region: GntR; COG1802
224308012317	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308012318	DNA-binding site [nucleotide binding]; DNA binding site
224308012319	FCD domain; Region: FCD; pfam07729
224308012320	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
224308012321	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
224308012322	N- and C-terminal domain interface [polypeptide binding]; other site
224308012323	active site
224308012324	catalytic site [active]
224308012325	metal binding site [ion binding]; metal-binding site
224308012326	carbohydrate binding site [chemical binding]; other site
224308012327	ATP binding site [chemical binding]; other site
224308012328	fructuronate transporter; Provisional; Region: PRK10034; cl15264
224308012329	gluconate transporter; Region: gntP; TIGR00791
224308012330	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873
224308012331	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
224308012332	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
224308012333	peroxiredoxin; Region: AhpC; TIGR03137
224308012334	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
224308012335	dimer interface [polypeptide binding]; other site
224308012336	decamer (pentamer of dimers) interface [polypeptide binding]; other site
224308012337	catalytic triad [active]
224308012338	peroxidatic and resolving cysteines [active]
224308012339	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
224308012340	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
224308012341	catalytic residue [active]
224308012342	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
224308012343	catalytic residues [active]
224308012344	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
224308012345	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224308012346	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
224308012347	beta-galactosidase; Region: BGL; TIGR03356
224308012348	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
224308012349	HPr interaction site; other site
224308012350	active site
224308012351	phosphorylation site [posttranslational modification]
224308012352	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
224308012353	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
224308012354	DNA-binding site [nucleotide binding]; DNA binding site
224308012355	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
224308012356	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
224308012357	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
224308012358	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
224308012359	Walker A/P-loop; other site
224308012360	ATP binding site [chemical binding]; other site
224308012361	Q-loop/lid; other site
224308012362	ABC transporter signature motif; other site
224308012363	Walker B; other site
224308012364	D-loop; other site
224308012365	H-loop/switch region; other site
224308012366	peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078
224308012367	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224308012368	FeS/SAM binding site; other site
224308012369	exported signaling peptide, YydF/SAG_2028 family; Region: expor_sig_YdyF; TIGR04077
224308012370	Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855
224308012371	Predicted ATPase [General function prediction only]; Region: COG5293
224308012372	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
224308012373	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
224308012374	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
224308012375	putative active site [active]
224308012376	putative metal binding site [ion binding]; other site
224308012377	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
224308012378	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
224308012379	CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129
224308012380	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
224308012381	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
224308012382	NAD binding site [chemical binding]; other site
224308012383	catalytic Zn binding site [ion binding]; other site
224308012384	structural Zn binding site [ion binding]; other site
224308012385	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
224308012386	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
224308012387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308012388	Coenzyme A binding pocket [chemical binding]; other site
224308012389	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308012390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224308012391	binding surface
224308012392	TPR motif; other site
224308012393	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224308012394	Arginase family; Region: Arginase; cd09989
224308012395	agmatinase; Region: agmatinase; TIGR01230
224308012396	active site
224308012397	Mn binding site [ion binding]; other site
224308012398	oligomer interface [polypeptide binding]; other site
224308012399	S-methylmethionine transporter; Provisional; Region: PRK11387
224308012400	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
224308012401	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224308012402	inhibitor-cofactor binding pocket; inhibition site
224308012403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224308012404	catalytic residue [active]
224308012405	PAS domain; Region: PAS; smart00091
224308012406	PAS domain; Region: PAS_9; pfam13426
224308012407	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
224308012408	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224308012409	Walker A motif; other site
224308012410	ATP binding site [chemical binding]; other site
224308012411	Walker B motif; other site
224308012412	arginine finger; other site
224308012413	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
224308012414	Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId: 17198402; Product type pr : regulator
224308012415	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
224308012416	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
224308012417	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224308012418	protein binding site [polypeptide binding]; other site
224308012419	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
224308012420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
224308012421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
224308012422	YycH protein; Region: YycH; pfam07435
224308012423	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
224308012424	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224308012425	dimerization interface [polypeptide binding]; other site
224308012426	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224308012427	putative active site [active]
224308012428	heme pocket [chemical binding]; other site
224308012429	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224308012430	dimer interface [polypeptide binding]; other site
224308012431	phosphorylation site [posttranslational modification]
224308012432	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224308012433	ATP binding site [chemical binding]; other site
224308012434	Mg2+ binding site [ion binding]; other site
224308012435	G-X-G motif; other site
224308012436	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224308012437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224308012438	active site
224308012439	phosphorylation site [posttranslational modification]
224308012440	intermolecular recognition site; other site
224308012441	dimerization interface [polypeptide binding]; other site
224308012442	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224308012443	DNA binding site [nucleotide binding]
224308012444	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
224308012445	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
224308012446	GDP-binding site [chemical binding]; other site
224308012447	ACT binding site; other site
224308012448	IMP binding site; other site
224308012449	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308012450	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
224308012451	active site
224308012452	replicative DNA helicase; Provisional; Region: PRK05748
224308012453	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
224308012454	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
224308012455	Walker A motif; other site
224308012456	ATP binding site [chemical binding]; other site
224308012457	Walker B motif; other site
224308012458	DNA binding loops [nucleotide binding]
224308012459	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
224308012460	YycC-like protein; Region: YycC; pfam14174
224308012461	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012462	cyanate transporter; Region: CynX; TIGR00896
224308012463	putative substrate translocation pore; other site
224308012464	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
224308012465	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
224308012466	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
224308012467	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
224308012468	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
224308012469	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
224308012470	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
224308012471	diguanylate cyclase; Region: GGDEF; smart00267
224308012472	DHH family; Region: DHH; pfam01368
224308012473	DHHA1 domain; Region: DHHA1; pfam02272
224308012474	Predicted membrane protein [Function unknown]; Region: COG4241
224308012475	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
224308012476	Predicted transcriptional regulators [Transcription]; Region: COG1733
224308012477	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
224308012478	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
224308012479	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
224308012480	DHHA2 domain; Region: DHHA2; pfam02833
224308012481	ANTAR domain; Region: ANTAR; cl04297
224308012482	D-galactonate transporter; Region: 2A0114; TIGR00893
224308012483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012484	putative substrate translocation pore; other site
224308012485	Evidence 5: No homology to any previously reported sequences
224308012486	Evidence 5: No homology to any previously reported sequences
224308012487	Evidence 4: Homologs of previously reported genes of unknown function
224308012488	Evidence 4: Homologs of previously reported genes of unknown function
224308012489	Protein of unknown function (DUF2712); Region: DUF2712; pfam10916
224308012490	Protein of unknown function (DUF2705); Region: DUF2705; pfam10920
224308012491	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
224308012492	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
224308012493	Walker A/P-loop; other site
224308012494	ATP binding site [chemical binding]; other site
224308012495	Q-loop/lid; other site
224308012496	ABC transporter signature motif; other site
224308012497	Walker B; other site
224308012498	D-loop; other site
224308012499	H-loop/switch region; other site
224308012500	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
224308012501	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
224308012502	SnoaL-like domain; Region: SnoaL_3; pfam13474
224308012503	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
224308012504	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
224308012505	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
224308012506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012507	putative substrate translocation pore; other site
224308012508	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224308012509	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224308012510	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224308012511	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
224308012512	putative dimerization interface [polypeptide binding]; other site
224308012513	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308012514	Coenzyme A binding pocket [chemical binding]; other site
224308012515	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224308012516	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
224308012517	MarR family; Region: MarR; pfam01047
224308012518	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308012519	Coenzyme A binding pocket [chemical binding]; other site
224308012520	Predicted membrane protein [Function unknown]; Region: COG2364
224308012521	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
224308012522	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224308012523	Coenzyme A binding pocket [chemical binding]; other site
224308012524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
224308012525	RibD C-terminal domain; Region: RibD_C; cl17279
224308012526	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
224308012527	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
224308012528	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012529	putative substrate translocation pore; other site
224308012530	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
224308012531	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
224308012532	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224308012533	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
224308012534	DNA binding residues [nucleotide binding]
224308012535	putative dimer interface [polypeptide binding]; other site
224308012536	EamA-like transporter family; Region: EamA; pfam00892
224308012537	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
224308012538	EamA-like transporter family; Region: EamA; pfam00892
224308012539	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
224308012540	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
224308012541	catalytic residues [active]
224308012542	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
224308012543	CAAX protease self-immunity; Region: Abi; pfam02517
224308012544	benzoate transport; Region: 2A0115; TIGR00895
224308012545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012546	putative substrate translocation pore; other site
224308012547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224308012548	maltose O-acetyltransferase; Provisional; Region: PRK10092
224308012549	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
224308012550	active site
224308012551	substrate binding site [chemical binding]; other site
224308012552	trimer interface [polypeptide binding]; other site
224308012553	CoA binding site [chemical binding]; other site
224308012554	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
224308012555	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
224308012556	putative metal binding site [ion binding]; other site
224308012557	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
224308012558	DNA binding site [nucleotide binding]
224308012559	domain linker motif; other site
224308012560	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
224308012561	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
224308012562	putative dimerization interface [polypeptide binding]; other site
224308012563	putative ligand binding site [chemical binding]; other site
224308012564	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
224308012565	active site
224308012566	putative catalytic site [active]
224308012567	DNA binding site [nucleotide binding]
224308012568	putative phosphate binding site [ion binding]; other site
224308012569	metal binding site A [ion binding]; metal-binding site
224308012570	AP binding site [nucleotide binding]; other site
224308012571	metal binding site B [ion binding]; metal-binding site
224308012572	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
224308012573	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
224308012574	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
224308012575	dimer interface [polypeptide binding]; other site
224308012576	ssDNA binding site [nucleotide binding]; other site
224308012577	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224308012578	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
224308012579	GTP-binding protein YchF; Reviewed; Region: PRK09601
224308012580	YchF GTPase; Region: YchF; cd01900
224308012581	G1 box; other site
224308012582	GTP/Mg2+ binding site [chemical binding]; other site
224308012583	Switch I region; other site
224308012584	G2 box; other site
224308012585	Switch II region; other site
224308012586	G3 box; other site
224308012587	G4 box; other site
224308012588	G5 box; other site
224308012589	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
224308012590	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
224308012591	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
224308012592	putative [4Fe-4S] binding site [ion binding]; other site
224308012593	putative molybdopterin cofactor binding site [chemical binding]; other site
224308012594	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
224308012595	molybdopterin cofactor binding site; other site
224308012596	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
224308012597	Uncharacterized membrane protein [Function unknown]; Region: COG3949
224308012598	putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841
224308012599	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
224308012600	ParB-like nuclease domain; Region: ParB; smart00470
224308012601	KorB domain; Region: KorB; pfam08535
224308012602	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
224308012603	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
224308012604	P-loop; other site
224308012605	Magnesium ion binding site [ion binding]; other site
224308012606	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
224308012607	Magnesium ion binding site [ion binding]; other site
224308012608	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
224308012609	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
224308012610	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
224308012611	ParB-like nuclease domain; Region: ParB; smart00470
224308012612	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
224308012613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224308012614	S-adenosylmethionine binding site [chemical binding]; other site
224308012615	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
224308012616	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
224308012617	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
224308012618	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
224308012619	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
224308012620	trmE is a tRNA modification GTPase; Region: trmE; cd04164
224308012621	G1 box; other site
224308012622	GTP/Mg2+ binding site [chemical binding]; other site
224308012623	Switch I region; other site
224308012624	G2 box; other site
224308012625	Switch II region; other site
224308012626	G3 box; other site
224308012627	G4 box; other site
224308012628	G5 box; other site
224308012629	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
224308012630	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
224308012631	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
224308012632	G-X-X-G motif; other site
224308012633	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
224308012634	RxxxH motif; other site
224308012635	OxaA-like protein precursor; Validated; Region: PRK02944
224308012636	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
224308012637	ribonuclease P; Reviewed; Region: rnpA; PRK00499
224308012638	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399