-- dump date 20171216_103906 -- class Genbank::CDS -- table cds_note -- id note ZYRO0A00132g some similarities with uniprot|P36034 Saccharomyces cerevisiae YKL219W COS9 ZYRO0A00154g no similarity ZYRO0A00198g some similarities with uniprot|P47187 Saccharomyces cerevisiae YJR161C COS5 ZYRO0A00220g weakly similar to uniprot|P47187 Saccharomyces cerevisiae YJR161C COS5 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins ZYRO0A00242g some similarities with uniprot|Q70DG7 Saccharomyces cerevisiae YHL044W Putative integral membrane protein member of DUP240 gene family ZYRO0A00264g no similarity ZYRO0A00286g highly similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance ZYRO0A00308g similar to uniprot|P43548 Saccharomyces cerevisiae YFL055W AGP3 Low-affinity amino acid permease may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions transcription is induced under conditions of sulfur limitation ZYRO0A00330g similar to uniprot|P38358 Saccharomyces cerevisiae YBR293W VBA2 Permease of basic amino acids in the vacuolar membrane ZYRO0A00374g similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C ZYRO0A00396g similar to uniprot|P40579 and to YIR036C uniprot|P40580 Saccharomyces cerevisiae, Hypothetical ORFs ZYRO0A00440g similar to uniprot|P05085 Saccharomyces cerevisiae YML099C ARG81 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type involved in the regulation of arginine-responsive genes acts with Arg80p and Arg82p ZYRO0A00462g similar to uniprot|P11747 Saccharomyces cerevisiae YML098W ZYRO0A00484g similar to uniprot|Q03103 Saccharomyces cerevisiae YML130C ERO1 Glycoprotein required for oxidative protein folding in the endoplasmic reticulum ZYRO0A00506g similar to uniprot|P54787 Saccharomyces cerevisiae YML097C ZYRO0A00528g similar to uniprot|Q04489 Saccharomyces cerevisiae YML096W Hypothetical ORF ZYRO0A00550g similar to uniprot|P06838 Saccharomyces cerevisiae YML095C RAD10 Single-stranded DNA endonuclease (with Rad1p) cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) homolog of human XPF protein ZYRO0A00572g highly similar to uniprot|Q04493 Saccharomyces cerevisiae YML094W GIM5 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it ZYRO0A00594g similar to gnl|GLV|CAGL0H06985g Candida glabrata CAGL0H06985g and weakly similar to YML093W uniprot|Q04500 Saccharomyces cerevisiae YML093W UTP14 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0A00616g highly similar to uniprot|P23639 Saccharomyces cerevisiae YML092C PRE8 20S proteasome beta-type subunit ZYRO0A00638g conserved hypothetical protein ZYRO0A00682g similar to uniprot|P39103 Saccharomyces cerevisiae YML129C COX14 Mitochondrial membrane protein required for assembly of cytochrome c oxidase ZYRO0A00704g similar to uniprot|Q03104 Saccharomyces cerevisiae YML128C MSC1 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc1 mutants are defective in directing meiotic recombination events to homologous chromatids ZYRO0A00726g similar to uniprot|Q03124 Saccharomyces cerevisiae YML127W RSC9 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway ZYRO0A00748g similar to uniprot|Q02773 Saccharomyces cerevisiae YML091C RPM2 Protein component of mitochondrial RNase P along with the mitochondrially-encoded RNA subunit RPM1 Rnase P removes 5' extensions from tRNA precursors Rpm2p is also involved in maturation of RPM1 and in translation of mitochondrial mRNAs ZYRO0A00770g highly similar to gnl|GLV|KLLA0D10505g Kluyveromyces lactis KLLA0D10505g and highly similar to YML126C uniprot|P54839 Saccharomyces cerevisiae YML126C ERG13 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA involved in the second step in mevalonate biosynthesis ZYRO0A00792g similar to uniprot|Q04511 Saccharomyces cerevisiae YML088W UFO1 F-box receptor protein subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex binds to phosphorylated Ho endonuclease allowing its ubiquitylation by SCF and subsequent degradation ZYRO0A00814g similar to uniprot|Q12746 Saccharomyces cerevisiae YML125C Protein required for cell viability ZYRO0A00836g highly similar to uniprot|P54783 Saccharomyces cerevisiae YML086C ALO1 D-Arabinono-1 4-lactone oxidase catalyzes the final step in biosynthesis of D-erythroascorbic acid which is protective against oxidative stress ZYRO0A00858g no similarity ZYRO0A00880g highly similar to uniprot|P09733 Saccharomyces cerevisiae YML085C TUB1 Alpha-tubulin associates with beta-tubulin (Tub2p) to form tubulin dimer which polymerizes to form microtubules ZYRO0A00902g similar to uniprot|P25297 Saccharomyces cerevisiae YML123C PHO84 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter regulated by Pho4p and Spt7p mutation confers resistance to arsenate exit from the ER during maturation requires Pho86p ZYRO0A00924g similar to uniprot|P29704 Saccharomyces cerevisiae YHR190W ERG9 Farnesyl-diphosphate farnesyl transferase (squalene synthase) joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway ZYRO0A00946g similar to uniprot|P38876 Saccharomyces cerevisiae YHR189W PTH1 One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases dispensable for cell growth and for mitochondrial respiration ZYRO0A00968g highly similar to uniprot|Q00582 Saccharomyces cerevisiae YML121W GTR1 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle through its homolog and binding partner Gtr2p involved in phosphate transport and invasive growth human RagA and RagB proteins are functional homologs ZYRO0A00990g some similarities with uniprot|P40463 Saccharomyces cerevisiae YIL135C VHS2 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation ZYRO0A01034g similar to uniprot|P32048 Saccharomyces cerevisiae YNL073W MSK1 Mitochondrial lysine-tRNA synthetase required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria ZYRO0A01078g weakly similar to uniprot|Q75D69 Ashbya gossypii ABR154C ABR154Cp ZYRO0A01100g similar to uniprot|P53942 Saccharomyces cerevisiae YNL072W RNH201 Ribonuclease H2 catalytic subunit removes RNA primers during Okazaki fragment synthesis cooperates with Rad27p nuclease ZYRO0A01122g similar to uniprot|Q08911 Saccharomyces cerevisiae YOR388C FDH1 NAD()-dependent formate dehydrogenase may protect cells from exogenous formate ZYRO0A01144g similar to uniprot|P12695 Saccharomyces cerevisiae YNL071W LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA ZYRO0A01166g similar to uniprot|P53507 Saccharomyces cerevisiae YNL070W TOM7 Involved in mitochondrial protein import translocase of the outer mito. membrane ZYRO0A01188g similar to uniprot|P40464 Saccharomyces cerevisiae YIL134W FLX1 Protein required for transport of flavin adenine dinucleotide (FAD) from mitochondria where it is synthesized from riboflavin to the cytosol ZYRO0A01210g similar to uniprot|P26784 Saccharomyces cerevisiae YIL133C RPL16A N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p and to YNL069C uniprot|P26785 Saccharomyces cerevisiae YNL069C RPL16B N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p ZYRO0A01232g similar to uniprot|P40465 Saccharomyces cerevisiae YIL132C CSM2 Protein required for accurate chromosome segregation during meiosis ZYRO0A01254g some similarities with uniprot|P41813 Saccharomyces cerevisiae YNL068C FKH2 Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth also involved in chromatin silencing at HML and HMR potential Cdc28p substrate ZYRO0A01276g similar to uniprot|P40468 Saccharomyces cerevisiae YIL129C TAO3 Identified in a hunt for mutants that activate OCH1 transcription Transcriptional Activator of OCH1 ZYRO0A01298g similar to uniprot|P40469 Saccharomyces cerevisiae YIL128W MET18 DNA repair and TFIIH regulator required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription possible role in assembly of a multiprotein complex(es) required for NER and RNAP II transcription ZYRO0A01320g similar to uniprot|P40470 Saccharomyces cerevisiae YIL127C Hypothetical ORF ZYRO0A01342g similar to uniprot|P32597 Saccharomyces cerevisiae YIL126W STH1 helicase related protein snf2 homolog ZYRO0A01364g highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins ZYRO0A01386g highly similar to uniprot|P20967 Saccharomyces cerevisiae YIL125W KGD1 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a key step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA ZYRO0A01408g similar to uniprot|P40471 Saccharomyces cerevisiae YIL124W AYR1 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles and ER involved in phosphatidic acid biosynthesis and required for spore germination capable of metabolizing mammalian steroid hormones ZYRO0A01430g some similarities with gnl|GLV|CAGL0J09922g Candida glabrata CAGL0J09922g and some similarities with uniprot|P40472 Saccharomyces cerevisiae YIL123W SIM1 (putative) invovled in control of DNA replication or uniprot|P53616 Saccharomyces cerevisiae YNL066W SUN4 Protein involved in the aging process ZYRO0A01452g weakly similar to uniprot|P40473 Saccharomyces cerevisiae YIL122W ZYRO0A01474g similar to uniprot|P40474 Saccharomyces cerevisiae YIL121W QDR2 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR) ZYRO0A01496g highly similar to gnl|GLV|CAGL0J09966g Candida glabrata CAGL0J09966g and similar to YNL064C uniprot|P25491 Saccharomyces cerevisiae YNL064C YDJ1 yeast dnaJ homolog (nuclear envelope protein) heat shock protein ZYRO0A01518g similar to uniprot|P53944 Saccharomyces cerevisiae YNL063W MTQ1 ZYRO0A01540g similar to uniprot|P41814 Saccharomyces cerevisiae YNL062C GCD10 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression ZYRO0A01562g similar to uniprot|P40991 Saccharomyces cerevisiae YNL061W NOP2 Probable RNA m(5)C methyltransferase essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis localized to the nucleolus ZYRO0A01584g highly similar to uniprot|P53946 Saccharomyces cerevisiae YNL059C ARP5 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes ZYRO0A01606g highly similar to uniprot|Q00245 Saccharomyces cerevisiae YIL118W RHO3 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p ZYRO0A01628g some similarities with uniprot|P53947 Saccharomyces cerevisiae YNL058C ZYRO0A01650g highly similar to uniprot|P53949 Saccharomyces cerevisiae YNL056W Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive- strand RNA viruses in their natural hosts ZYRO0A01672g highly similar to uniprot|P07172 Saccharomyces cerevisiae YIL116W HIS5 Histidinol-phosphate aminotransferase catalyzes the seventh step in histidine biosynthesis responsive to general control of amino acid biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts ZYRO0A01694g similar to uniprot|P40477 Saccharomyces cerevisiae YIL115C NUP159 Subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side forms a subcomplex with Nup82p and Nsp1p required for mRNA export ZYRO0A01716g highly similar to uniprot|P04840 Saccharomyces cerevisiae YNL055C POR1 Mitochondrial porin (voltage-dependent anion channel) outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability ZYRO0A01738g weakly similar to uniprot|P53950 Saccharomyces cerevisiae YNL054W VAC7 Integral vacuolar membrane protein may function to regulate Fab1p kinase activity ZYRO0A01760g weakly similar to uniprot|P38590 Saccharomyces cerevisiae YNL053W MSG5 Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway regulates and is regulated by Slt2p also required for adaptive response to pheromone ZYRO0A01782g similar to uniprot|P53960 Saccharomyces cerevisiae YNL040W Hypothetical ORF ZYRO0A01804g similar to uniprot|P53962 Saccharomyces cerevisiae YNL035C Hypothetical ORF ZYRO0A01848g similar to uniprot|P40494 Saccharomyces cerevisiae YIL095W PRK1 Protein serine/threonine kinase regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex ZYRO0A01870g highly similar to uniprot|P53973 Saccharomyces cerevisiae YNL021W HDA1 Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer deletion increases histone H2B H3 and H4 acetylation ZYRO0A01892g similar to uniprot|P53972 Saccharomyces cerevisiae YNL022C ZYRO0A01914g highly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate ZYRO0A01936g similar to uniprot|P53971 Saccharomyces cerevisiae YNL023C ZYRO0A01958g similar to uniprot|P40496 Saccharomyces cerevisiae YIL093C RSM25 Mitochondrial ribosomal protein of the small subunit ZYRO0A01980g highly similar to uniprot|Q8TGJ3 Saccharomyces cerevisiae YNL024C-A Identified by gene-trapping microarray-based expression analysis and genome-wide homology searching ZYRO0A02002g similar to uniprot|P40498 Saccharomyces cerevisiae YIL091C Protein required for cell viability ZYRO0A02024g similar to uniprot|P40499 Saccharomyces cerevisiae YIL090W ICE2 Integral ER membrane protein with type-III transmembrane domains mutations cause defects in cortical ER morphology in both the mother and daughter cells ZYRO0A02068g highly similar to uniprot|P47821 Saccharomyces cerevisiae YNL025C SSN8 Component of RNA polymerase II holoenzyme involved in RNA pol II carboxy-terminal domain phosphorylation ZYRO0A02112g similar to uniprot|P40501 Saccharomyces cerevisiae YIL088C AVT7 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ZYRO0A02134g some similarities with uniprot|P53965 Saccharomyces cerevisiae YNL032W SIW14 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis localized to the cytoplasm ZYRO0A02156g similar to uniprot|P40502 Saccharomyces cerevisiae YIL087C Hypothetical ORF ZYRO0A02178g highly similar to uniprot|P61830 Saccharomyces cerevisiae YNL031C one of two identical histone H3 proteins ZYRO0A02200g highly similar to uniprot|P02309 YBR009C and to uniprot|P02309 YNL030W Saccharomyces cerevisiae, HHF1 and HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity ZYRO0A02222g similar to uniprot|P40504 Saccharomyces cerevisiae YIL085C KTR7 Putative mannosyltransferase involved in protein glycosylation member of the KRE2/MNT1 mannosyltransferase family or uniprot|P53966 Saccharomyces cerevisiae YNL029C KTR5 ZYRO0A02244g similar to uniprot|P40505 Saccharomyces cerevisiae YIL084C ZYRO0A02266g similar to uniprot|Q04235 Saccharomyces cerevisiae YML005W TRM12 Putative tRNA methyltransferase has a role in tRNA modification S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family ZYRO0A02288g similar to uniprot|Q288C3 Torulaspora delbrueckii CRZ1 Calcineurin-responsive zinc finger transcription factor and some similarites with YNL027W uniprot|P53968 Saccharomyces cerevisiae YNL027W CRZ1 Transcription factor that activates transcription of genes involved in stress response nuclear localization is positively regulated by calcineurin-mediated dephosphorylation ZYRO0A02310g similar to uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM complex) of the mitochondrial outer membrane the authentic non-tagged protein was localized to the mitochondria ZYRO0A02332g highly similar to uniprot|P40506 Saccharomyces cerevisiae YIL083C Homolog to human PPCS ZYRO0A02398g similar to uniprot|P32588 Saccharomyces cerevisiae YNL016W PUB1 Poly(A) RNA-binding protein abundant mRNP-component protein hypothesized to bind a pool of non-translatable mRNAs not reported to associate with polyribosomes ZYRO0A02420g similar to uniprot|P25037 Saccharomyces cerevisiae YDL122W UBP1 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins cleaves at the C terminus of ubiquitin fusions irrespective of their size capable of cleaving polyubiquitin chains ZYRO0A02442g weakly similar to uniprot|Q07541 Saccharomyces cerevisiae YDL121C Hypothetical ORF ZYRO0A02464g similar to uniprot|Q07540 Saccharomyces cerevisiae YDL120W YFH1 Yeast Frataxin Homologue mitochondrial protein that regulates mitochondrial iron accumulation ZYRO0A02486g similar to uniprot|P22855 Saccharomyces cerevisiae YGL156W AMS1 vacuolar alpha mannosidase ZYRO0A02508g similar to uniprot|P18898 Saccharomyces cerevisiae YGL155W CDC43 Beta subunit of geranylgeranyltransferase type I catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe has substrates important for morphogenesis ZYRO0A02530g similar to uniprot|Q07534 Saccharomyces cerevisiae YDL119C Hypothetical ORF ZYRO0A02552g similar to uniprot|P50113 Saccharomyces cerevisiae YGL154C LYS5 Phosphopantetheinyl transferase involved in lysine biosynthesis converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine ZYRO0A02574g similar to uniprot|P53112 Saccharomyces cerevisiae YGL153W PEX14 Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p ZYRO0A02596g similar to uniprot|P53114 Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription ZYRO0A02618g similar to uniprot|P53115 Saccharomyces cerevisiae YGL150C INO80 ATPase that forms a large complex containing actin and several actin-related proteins ZYRO0A02640g highly similar to uniprot|P28777 Saccharomyces cerevisiae YGL148W ARO2 Bifunctional chorismate synthase and flavin reductase catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate which is a precursor to aromatic amino acids ZYRO0A02662g similar to uniprot|Q07533 Saccharomyces cerevisiae YDL117W CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring mutant phenotype and genetic interactions suggest a role in cytokinesis ZYRO0A02684g similar to uniprot|P52891 Saccharomyces cerevisiae YDL116W NUP84 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup85p Nup120p Nup145p-C Sec13p and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis ZYRO0A02706g similar to uniprot|P32580 Saccharomyces cerevisiae YPL029W SUV3 ATP-dependent RNA helicase component of the mitochondrial degradosome ZYRO0A02728g highly similar to uniprot|P41338 Saccharomyces cerevisiae YPL028W ERG10 Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another forming acetoacetyl-CoA involved in the first step in mevalonate biosynthesis ZYRO0A02750g similar to uniprot|Q03786 Saccharomyces cerevisiae YDR248C Hypothetical ORF ZYRO0A02772g similar to uniprot|Q12505 Saccharomyces cerevisiae YPL026C SKS1 multicopy suppressor of snf3 and grr1 mutants serine/threonine protein kinase homologous to Ran1p ZYRO0A02794g similar to uniprot|Q03784 Saccharomyces cerevisiae YDR246W TRS23 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic ZYRO0A02816g similar to uniprot|Q02685 Saccharomyces cerevisiae YPL024W RMI1 Protein of unknown function GFP tagged protein localizes to the cytoplasm and nucleus ZYRO0A02838g highly similar to uniprot|P46151 Saccharomyces cerevisiae YPL023C MET12 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway ZYRO0A02860g similar to uniprot|P06777 Saccharomyces cerevisiae YPL022W RAD1 Single-stranded DNA endonuclease ZYRO0A02882g some similarities with uniprot|P09547 Saccharomyces cerevisiae YPL016W SWI1 Global transcription activator that acts in complex with Snf2p Snf5p Snf6p and Swi3p to assist gene-specific activators involved in the regulation of expression of many genes including ADH1 ADH2 GAL1 HO INO1 and SUC2 Zinc-finger transcription factor ZYRO0A02904g similar to uniprot|P50108 Saccharomyces cerevisiae YDR245W MNN10 Subunit of a Golgi mannosyltransferase complex also containing Anp1p Mnn9p Mnn11p and Hoc1p that mediates elongation of the polysaccharide mannan backbone membrane protein of the mannosyltransferase family ZYRO0A02926g similar to uniprot|P35056 Saccharomyces cerevisiae YDR244W PEX5 Essential for import of proteins with SKL-like import signal into peroxisomal matrix 69-kDa protein containing tetratricopeptide repeat (TPR) ZYRO0A02948g similar to uniprot|P23394 Saccharomyces cerevisiae YDR243C PRP28 RNA helicase in the DEAD-box family involved in RNA isomerization at the 5' splice site ZYRO0A02970g similar to uniprot|Q12046 Saccharomyces cerevisiae YDL209C CWC2 Protein involved in pre-mRNA splicing ZYRO0A03036g similar to uniprot|P19735 Saccharomyces cerevisiae YBR055C PRP6 Splicing factor component of the U4/U6-U5 snRNP complex ZYRO0A03058g similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co-inducer ZYRO0A03080g conserved hypothetical protein ZYRO0A03102g conserved hypothetical protein ZYRO0A03124g similar to uniprot|Q12335 Saccharomyces cerevisiae YDR032C PST2 ZYRO0A03146g similar to uniprot|P38235 Saccharomyces cerevisiae YBR053C Hypothetical ORF ZYRO0A03168g similar to uniprot|P38079 Saccharomyces cerevisiae YBR054W YRO2 Putative plasma membrane protein of unknown function transcriptionally regulated by Haa1p green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud ZYRO0A03190g highly similar to uniprot|Q12335 Saccharomyces cerevisiae YDR032C PST2 Protein of unknown function with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; GFP-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0A03212g similar to uniprot|Q07789 Saccharomyces cerevisiae YDR031W Hypothetical ORF ZYRO0A03234g similar to uniprot|Q12021 Saccharomyces cerevisiae YDR030C RAD28 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSA protein ZYRO0A03256g weakly similar to uniprot|Q00816 Saccharomyces cerevisiae YDR028C REG1 Regulatory subunit of type 1 protein phosphatase Glc7p involved in negative regulation of glucose-repressible genes involved in RNA processing ZYRO0A03278g similar to uniprot|Q12071 Saccharomyces cerevisiae YDR027C VPS54 Component of the GARP (Golgi-associated retrograde protein) complex ZYRO0A03300g similar to gnl|GLV|KLLA0F04389g Kluyveromyces lactis KLLA0F04389g and some similarites with YDR026C uniprot|Q12457 Saccharomyces cerevisiae YDR026C Hypothetical ORF ZYRO0A03322g highly similar to uniprot|P26781 Saccharomyces cerevisiae YDR025W RPS11A Protein component of the small (40S) ribosomal subunit or uniprot|P26781 Saccharomyces cerevisiae YBR048W RPS11B ZYRO0A03344g similar to uniprot|P38231 Saccharomyces cerevisiae YBR047W FMP23 The authentic non-tagged protein was localized to the mitochondria ZYRO0A03366g highly similar to uniprot|P38230 Saccharomyces cerevisiae YBR046C ZTA1 Zeta-crystallin homolog ZYRO0A03388g weakly similar to uniprot|P38229 Saccharomyces cerevisiae YBR045C GIP1 Meiosis-specific protein proposed to be a regulatory subunit of the protein phosphatase Glc7p required for spore wall formation and proper septin organization ZYRO0A03410g highly similar to uniprot|P07284 Saccharomyces cerevisiae YDR023W SES1 seryl-tRNA synthetase ZYRO0A03454g similar to uniprot|Q03939 Saccharomyces cerevisiae YDR022C CIS1 Protein involved in microtubule assembly ZYRO0A03476g highly similar to uniprot|Q12099 Saccharomyces cerevisiae YDR021W FAL1 Nucleolar protein required for maturation of 18S rRNA member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases ZYRO0A03498g similar to uniprot|Q12084 Saccharomyces cerevisiae YDR020C Hypothetical ORF ZYRO0A03520g similar to uniprot|P38228 Saccharomyces cerevisiae YBR044C TCM62 mitochondrial protein (putative) chaperone ZYRO0A03542g similar to YDR019C, uniprot|P48015 Saccharomyces cerevisiae YDR019C (GCV1) ZYRO0A03564g similar to YBR043C, uniprot|P38227 Saccharomyces cerevisiae YBR043C (QDR3) ZYRO0A03586g similar to uniprot|P38226 Saccharomyces cerevisiae YBR042C Hypothetical ORF ZYRO0A03608g similar to uniprot|P38225 Saccharomyces cerevisiae YBR041W FAT1 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids ZYRO0A03630g similar to uniprot|P38224 Saccharomyces cerevisiae YBR040W FIG1 Integral membrane protein required for efficient mating may participate in or regulate the low affinity Ca2 influx system which affects intracellular signaling and cell-cell fusion during mating ZYRO0A03652g highly similar to uniprot|P38077 Saccharomyces cerevisiae YBR039W ATP3 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis ZYRO0A03674g some similarities with uniprot|Q7LGR2 Saccharomyces cerevisiae YDR017C KCS1 Inositol hexaphosphate kinase phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates required for proper vacuole morphology and involved in salt stress response contains two leucine heptad repeats ZYRO0A03696g similar to gnl|GLV|CAGL0D04394g Candida glabrata CAGL0D04394g and some similarities with uniprot|Q12248 Saccharomyces cerevisiae YDR016C DAD1 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore ZYRO0A03718g conserved hypothetical protein ZYRO0A03740g highly similar to uniprot|P38075 Saccharomyces cerevisiae YBR035C PDX3 Pyridoxine (pyridoxamine) phosphate oxidase has homologs in E. coli and Myxococcus xanthus transcription is under the general control of nitrogen metabolism ZYRO0A03762g weakly similar to uniprot|Q99359 Saccharomyces cerevisiae YDR014W RAD61 Protein of unknown function mutation confers radiation sensitivity ZYRO0A03784g highly similar to uniprot|Q12488 Saccharomyces cerevisiae YDR013W PSF1 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery ZYRO0A03806g highly similar to uniprot|P38074 Saccharomyces cerevisiae YBR034C HMT1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs including Npl3p and Hrp1p thus facilitating nuclear export of these proteins required for viability of npl3 mutants ZYRO0A03828g highly similar to uniprot|P49626 Saccharomyces cerevisiae YDR012W RPL4B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4A ZYRO0A03850g similar to uniprot|P38222 Saccharomyces cerevisiae YBR030W Hypothetical ORF ZYRO0A03872g similar to uniprot|P38221 Saccharomyces cerevisiae YBR029C CDS1 Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) an enzyme that catalyzes that conversion of CTP phosphate into diphosphate CDP-diaclglyerol a critical step in the synthesis of all major yeast phospholipids ZYRO0A03894g similar to uniprot|P38070 Saccharomyces cerevisiae YBR028C Hypothetical ORF ZYRO0A03916g similar to uniprot|P38071 Saccharomyces cerevisiae YBR026C ETR1 2-enoyl thioester reductase member of the medium chain dehydrogenase/reductase family localized to in mitochondria where it has a probable role in fatty acid synthesis ZYRO0A03938g similar to gnl|GLV|CAGL0I04774g Candida glabrata CAGL0I04774g and some similarites with YBR036C uniprot|P35206 Saccharomyces cerevisiae YBR036C CSG2 Endoplasmic reticulum membrane protein required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations ZYRO0A03960g highly similar to uniprot|P38219 Saccharomyces cerevisiae YBR025C Hypothetical ORF ZYRO0A03982g similar to uniprot|P23833 Saccharomyces cerevisiae YBR037C ZYRO0A04004g highly similar to uniprot|P14180 Saccharomyces cerevisiae YBR038W CHS2 Chitin synthase II requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin required for the synthesis of chitin in the primary septum during cytokinesis ZYRO0A04026g conserved hypothetical protein ZYRO0A04048g similar to uniprot|P29465 Saccharomyces cerevisiae YBR023C CHS3 Chitin synthase III catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin required for synthesis of the majority of cell wall chitin the chitin ring during bud emergence and spore wall chitosan ZYRO0A04070g similar to uniprot|P38218 Saccharomyces cerevisiae YBR022W POA1 Phosphatase that is highly specific for ADP-ribose 1''-phosphate a tRNA splicing metabolite may have a role in regulation of tRNA splicing ZYRO0A04092g similar to uniprot|P05316 YBR021W Saccharomyces cerevisiae FUR4 Uracil permease localized to the plasma membrane ZYRO0A04114g similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 ABC transporter ZYRO0A04136g similar to uniprot|P13045 Saccharomyces cerevisiae YDR009W GAL3 Transcriptional regulator involved in activation of the GAL genes in response to galactose forms a complex with Gal80p and Gal4p to relieve inhibition by Gal80p binds galactose and ATP but does not have galactokinase activity and similar to YBR020W uniprot|P04385 Saccharomyces cerevisiae YBR020W GAL1 Galactokinase phosphorylates alpha-D-galactose to alpha-D-galactose-1- phosphate in the first step of galactose catabolism expression regulated by Gal4p ZYRO0A04158g similar to uniprot|P04397 Saccharomyces cerevisiae YBR019C GAL10 UDP-glucose-4-epimerase catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers ZYRO0A04180g highly similar to uniprot|P08431 Saccharomyces cerevisiae YBR018C GAL7 Galactose-1-phosphate uridyl transferase synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism ZYRO0A04224g highly similar to uniprot|P40327 Saccharomyces cerevisiae YDL007W RPT2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for normal peptide hydrolysis by the core 20S particle ZYRO0A04246g highly similar to uniprot|P35182 Saccharomyces cerevisiae YDL006W PTC1 Type 2C protein phosphatase (PP2C) inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p mutation delays mitochondrial inheritance deletion reveals defects in precursor tRNA splicing sporulation and cell separation ZYRO0A04268g weakly similar to uniprot|Q12124 Saccharomyces cerevisiae YDL005C MED2 RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex ZYRO0A04290g no similarity ZYRO0A04312g highly similar to gnl|GLV|KLLA0F14773g Kluyveromyces lactis KLLA0F14773g and similar to YDL004W uniprot|Q12165 Saccharomyces cerevisiae YDL004W ATP16 Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis ZYRO0A04334g similar to uniprot|Q05325 Saccharomyces cerevisiae YDL003W MCD1 Essential protein required for sister chromatid cohesion in mitosis and meiosis subunit of the cohesin complex expression is cell cycle regulated and peaks in S phase ZYRO0A04356g similar to uniprot|P35194 Saccharomyces cerevisiae YBL004W UTP20 Possible snoRNA-binding protein based on computational analysis of large-scale protein-protein interaction data ZYRO0A04378g similar to uniprot|Q03435 Saccharomyces cerevisiae YDL002C NHP10 Protein related to mammalian high mobility group proteins likely component of the INO80 complex which is an ATP-dependent chromatin-remodeling complex ZYRO0A04400g similar to uniprot|Q05210 Saccharomyces cerevisiae YDL001W RMD1 Cytoplasmic protein required for sporulation ZYRO0A04422g similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p ZYRO0A04444g similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation ZYRO0A04466g highly similar to uniprot|P35195 Saccharomyces cerevisiae YBL001C ECM15 Non-essential protein of unknown function likely exists as tetramer may be regulated by the binding of small-molecule ligands (possibly sulfate ions) may have a role in yeast cell-wall biogenesis ZYRO0A04488g no similarity ZYRO0A04510g no similarity ZYRO0A04554g highly similar to uniprot|P32356 Saccharomyces cerevisiae YDR001C NTH1 Neutral trehalase degrades trehalose required for thermotolerance and may mediate resistance to other cellular stresses may be phosphorylated by Cdc28p ZYRO0A04576g similar to uniprot|P41920 Saccharomyces cerevisiae YDR002W YRB1 Yeast Ran Binder #1 suppressor of FUS1 homolog of mouse HTF9a and human RanBP1 nuclear GTPase- activating protein for Ran ZYRO0A04598g similar to uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis-prenyltransferase involved in dolichol synthesis participates in endoplasmic reticulum (ER) protein sorting ZYRO0A04620g highly similar to uniprot|P18900 Saccharomyces cerevisiae YBR003W COQ1 Hexaprenyl pyrophosphate synthetase catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis ZYRO0A04642g similar to uniprot|P38211 Saccharomyces cerevisiae YBR004C GPI18 Functional ortholog of human PIG-V which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis the authentic non-tagged protein was localized to mitochondria ZYRO0A04664g similar to uniprot|Q03446 Saccharomyces cerevisiae YDR003W ZYRO0A04686g highly similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source part of the 4-aminobutyrate and glutamate degradation pathways localized to the cytoplasm ZYRO0A04708g similar to uniprot|P25301 Saccharomyces cerevisiae YDR004W RAD57 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad55p ZYRO0A04730g similar to uniprot|P41910 Saccharomyces cerevisiae YDR005C MAF1 Negative regulator of RNA polymerase III component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment targets the initiation factor TFIIIB ZYRO0A04752g weakly similar to uniprot|P38213 Saccharomyces cerevisiae YBR007C DSF2 ZYRO0A04774g weakly similar to YDR006C, uniprot|P40317 Saccharomyces cerevisiae YDR006C (SOK1) ZYRO0A04796g highly similar to uniprot|P02309 YBR009C and to uniprot|P02309 YNL030W Saccharomyces cerevisiae, HHF1 and HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity ZYRO0A04818g highly similar to uniprot|P61830 Saccharomyces cerevisiae YBR010W One of two identical histone H3 proteins ZYRO0A04840g similar to uniprot|P00912 Saccharomyces cerevisiae YDR007W TRP1 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis in 2004 the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) ZYRO0A04862g highly similar to uniprot|P00817 Saccharomyces cerevisiae YBR011C IPP1 Cytoplasmic inorganic pyrophosphatase (PPase) catalyzes the rapid exchange of oxygens from Pi with water highly expressed and essential for viability active-site residues show identity to those from E. coli PPase ZYRO0A04906g similar to uniprot|Q12157 Saccharomyces cerevisiae YDL008W APC11 Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition ZYRO0A04928g weakly similar to Saccharomyces cerevisiae YDL010W Hypothetical ORF or YBR014C uniprot|P38068 Saccharomyces cerevisiae YBR014C Hypothetical ORF ZYRO0A04950g similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment ZYRO0A04972g weakly similar to uniprot|P38216 Saccharomyces cerevisiae YBR016W ZYRO0A04994g similar to uniprot|P32828 Saccharomyces cerevisiae YDL013W HEX3 Ring finger protein involved in the DNA damage response with possible recombination role genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase) sporulation role interacts with Slx8p and Lin1p ZYRO0A05016g similar to uniprot|P15646 Saccharomyces cerevisiae YDL014W ZYRO0A05038g similar to uniprot|Q99190 Saccharomyces cerevisiae YDL015C TSC13 ER protein involved in very long chain fatty acid synthesis ZYRO0A05060g similar to uniprot|P06243 Saccharomyces cerevisiae YDL017W CDC7 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p kinase activity correlates with cyclical DBF4 expression ZYRO0A05082g similar to uniprot|Q12403 Saccharomyces cerevisiae YDL018C ZYRO0A05104g similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase converts allantoin to allantoate in the first step of allantoin degradation expression sensitive to nitrogen catabolite repression ZYRO0A05126g highly similar to uniprot|P38217 Saccharomyces cerevisiae YBR017C KAP104 Transportin cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm binds rg- nuclear localization signals on Nab2p and Hrp1p plays a role in cell-cycle progression ZYRO0A05148g weakly similar to uniprot|P27637 Saccharomyces cerevisiae YAR014C BUD14 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ZYRO0A05170g highly similar to uniprot|P27616 Saccharomyces cerevisiae YAR015W ADE1 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase required for 'de novo' purine nucleotide biosynthesis red pigment accumulates in mutant cells deprived of adenine ZYRO0A05192g highly similar to uniprot|P22209 Saccharomyces cerevisiae YAR018C KIN3 Nonessential protein kinase with unknown cellular role ZYRO0A05214g similar to uniprot|P27636 Saccharomyces cerevisiae YAR019C CDC15 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase promotes mitotic exit by directly switching on the kinase activity of Dbf2p ZYRO0A05236g similar to uniprot|P80235 YAR035W Saccharomyces cerevisiae YAT1 Outer carnitine acetyltransferase mitochondrial ZYRO0A05258g some similarities with uniprot|Q12451 Saccharomyces cerevisiae YDL019C OSH2 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability ZYRO0A05280g similar to uniprot|Q6B2F0 Saccharomyces cerevisiae YOL055C THI20 Hydroxymethylpyrimidine phosphate kinase involved in the last steps in thiamine biosynthesis member of a gene family with THI21 and THI22 functionally redundant with Thi21p ZYRO0A05302g some similarities with uniprot|Q03465 Saccharomyces cerevisiae YDL020C RPN4 Transcription factor that stimulates expression of proteasome genes Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism RPN4 is transcriptionally regulated by various stress responses ZYRO0A05324g highly similar to uniprot|Q12326 Saccharomyces cerevisiae YOL056W GPM3 Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis may be non-functional derivative of a gene duplication event ZYRO0A05346g similar to uniprot|Q08225 Saccharomyces cerevisiae YOL057W Hypothetical ORF ZYRO0A05368g highly similar to uniprot|P22768 Saccharomyces cerevisiae YOL058W ARG1 Arginosuccinate synthetase catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway potential Cdc28p substrate ZYRO0A05390g highly similar to uniprot|Q00055 Saccharomyces cerevisiae YDL022W GPD1 NAD-dependent glycerol-3-phosphate dehydrogenase key enzyme of glycerol synthesis essential for growth under osmotic stress expression regulated by high-osmolarity glycerol response pathway homolog of Gpd2p ZYRO0A05412g highly similar to uniprot|Q12314 Saccharomyces cerevisiae YOR021C ZYRO0A05434g highly similar to uniprot|P38910 Saccharomyces cerevisiae YOR020C HSP10 Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p ZYRO0A05456g weakly similar to uniprot|Q03338 Saccharomyces cerevisiae YDR473C PRP3 Splicing factor component of the U4/U6-U5 snRNP complex ZYRO0A05478g some similarities with uniprot|Q99248 Saccharomyces cerevisiae YOR019W ZYRO0A05500g conserved hypothetical protein ZYRO0A05522g similar to uniprot|Q03362 Saccharomyces cerevisiae YDR476C Hypothetical ORF ZYRO0A05544g highly similar to uniprot|P06782 Saccharomyces cerevisiae YDR477W SNF1 Protein serine/threonine kinase required for release from glucose repression invertase expression sporulation and for expression of catabolite-repressed genes when glucose is limiting regulates Adr1p-dependent transcription primarily at the level of chromatin binding ZYRO0A05566g similar to uniprot|P53687 Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD()-dependent protein deacetylases involved along with Hst4p in telomeric silencing cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism ZYRO0A05588g some similarities with uniprot|P40993 Saccharomyces cerevisiae YDR478W SNM1 Subunit of RNase MRP which cleaves pre-rRNA not shared between Rnase MRP and nuclear Rnase P in contrast to all other Rnase MRP protein subunits binds to the NME1 RNA subunit of Rnase MRP ZYRO0A05610g similar to uniprot|Q03370 Saccharomyces cerevisiae YDR479C PEX29 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p ZYRO0A05632g similar to uniprot|P26449 Saccharomyces cerevisiae YOR026W BUB3 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase delays anaphase in the presence of unattached kinetochores forms complexes with Mad1p-Bub1p and with Cdc20p binds Mad2p and Mad3p ZYRO0A05654g similar to uniprot|Q07015 Saccharomyces cerevisiae YDR257C SET7 Nuclear protein that contains a SET-domain which have been shown to mediate methyltransferase activity in other proteins ZYRO0A05676g highly similar to uniprot|P15705 Saccharomyces cerevisiae YOR027W STI1 Heat shock protein also induced by canavanine and entry into stationary phase ZYRO0A05742g highly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP()-dependent dehydrogenase acts on serine L-allo-threonine and other 3-hydroxy acids ZYRO0A05764g similar to uniprot|Q12012 Saccharomyces cerevisiae YOR289W Hypothetical ORF ZYRO0A05786g similar to uniprot|Q12404 Saccharomyces cerevisiae YOR288C MPD1 Member of the protein disulfide isomerase (PDI) family overexpression suppresses the defect in maturation of carboxypeptidase Y and defects in other essential Pdi1p functions caused by PDI1 deletion ZYRO0A05808g similar to uniprot|P19956 Saccharomyces cerevisiae YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit ZYRO0A05830g similar to uniprot|Q12481 Saccharomyces cerevisiae YOR287C Protein required for cell viability ZYRO0A05852g similar to uniprot|Q08742 Saccharomyces cerevisiae YOR286W FMP31 The authentic non-tagged protein was localized to the mitochondria ZYRO0A05874g weakly similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF ZYRO0A05896g similar to uniprot|Q12040 Saccharomyces cerevisiae YOR283W Hypothetical ORF ZYRO0A05918g similar to uniprot|P32829 Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability exhibits nuclease activity that appears to be required for RMX function widely conserved ZYRO0A05940g similar to uniprot|Q12017 Saccharomyces cerevisiae YOR281C ZYRO0A05962g similar to uniprot|P50102 Saccharomyces cerevisiae YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex required for SAGA-mediated deubiquitination of histone H2B ZYRO0A05984g similar to uniprot|Q05015 Saccharomyces cerevisiae YMR222C and similar to uniprot|Q99369 Saccharomyces cerevisiae YOR280C ZYRO0A06006g similar to Saccharomyces cerevisiae and to YMR222C uniprot|Q05015 Saccharomyces cerevisiae FSH2 Serine hydrolase ZYRO0A06028g similar to uniprot|Q04991 Saccharomyces cerevisiae YMR221C FMP42 The authentic non-tagged protein was localized to the mitochondria ZYRO0A06050g weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for repression of middle sporulation genes specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p ZYRO0A06072g similar to uniprot|P24521 Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate ZYRO0A06094g some similarities with uniprot|Q03661 Saccharomyces cerevisiae YMR219W ESC1 Protein localized to the nuclear periphery involved in telomeric silencing interacts with PAD4-domain of Sir4p ZYRO0A06116g similar to uniprot|Q03660 Saccharomyces cerevisiae YMR218C TRS130 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic ZYRO0A06138g similar to uniprot|P06174 Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III the fourth step in the heme biosynthetic pathway ZYRO0A06160g highly similar to uniprot|P38625 Saccharomyces cerevisiae YMR217W GUA1 GMP synthase an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP) transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation ZYRO0A06182g similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C ZYRO0A06204g similar to uniprot|Q03655 Saccharomyces cerevisiae YMR215W GAS3 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall ZYRO0A06226g similar to uniprot|P25303 Saccharomyces cerevisiae YMR214W SCJ1 dnaJ homolog ZYRO0A06248g similar to uniprot|P12962 Saccharomyces cerevisiae YOR276W CAF20 Phosphoprotein of the mRNA cap-binding complex involved in translational control repressor of cap-dependent translation initiation competes with eIF4G for binding to eIF4E ZYRO0A06270g highly similar to uniprot|P32468 Saccharomyces cerevisiae YHR107C CDC12 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM ZYRO0A06292g highly similar to uniprot|P29509 YDR353W Saccharomyces cerevisiae TRR1 Thioredoxin reductase ZYRO0A06314g similar to gnl|GLV|CAGL0I01144g Candida glabrata CAGL0I01144g and some similarities with uniprot|P38815 Saccharomyces cerevisiae YHR105W YPT35 Hypothetical ORF ZYRO0A06336g highly similar to uniprot|P38715 Saccharomyces cerevisiae YHR104W GRE3 Aldose reductase involved in methylglyoxal d-xylose and arabinose metabolism stress induced (osmotic ionic oxidative heat shock starvation and heavy metals) regulated by the HOG pathway ZYRO0A06358g similar to uniprot|Q06328 YDR352w Saccharomyces cerevisiae Hypothetical ORF ZYRO0A06380g similar to uniprot|P38814 YHR103W Saccharomyces cerevisiae SBE Protein involved in the transport of cell wall components from the Golgi to the cell surface ZYRO0A06446g weakly similar to uniprot|P38692 Saccharomyces cerevisiae YHR102W KIC1 Protein kinase of the PAK/Ste20 kinase family required for cell integrity possibly through regulating 1 6-beta-glucan levels in the wall physically interacts with Cdc31p (centrin) which is a component of the spindle pole body ZYRO0A06468g weakly similar to uniprot|P50273 YDR350C Saccharomyces cerevisiae CM10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase ZYRO0A06490g similar to uniprot|P38813 Saccharomyces cerevisiae YHR101C BIG1 Integral membrane protein of the endoplasmic reticulum required for normal content of cell wall beta-1 6-glucan ZYRO0A06512g similar to uniprot|P38812 Saccharomyces cerevisiae YHR100C Hypothetical ORF ZYRO0A06534g highly similar to uniprot|P38811 Saccharomyces cerevisiae YHR099W TRA1 Histone acetyltransferase component putative ortholog of human TRRAP which is an essential cofactor of c-Myc ZYRO0A06578g similar to uniprot|Q66RD4 Saccharomyces cerevisiae YDR349C YPS7 Putative GPI-anchored aspartic protease located in the cytoplasm and endoplasmic reticulum ZYRO0A06600g similar to uniprot|P38810 Saccharomyces cerevisiae YHR098C SFB3 Member of the Sec24p family forms a complex with Sec23p that is involved in sorting of Pma1p into COPII vesicles peripheral ER membrane protein potential Cdc28p substrate ZYRO0A06622g similar to gnl|GLV|KLLA0F22154g Kluyveromyces lactis KLLA0F22154g and some similarites with YDR348C uniprot|Q66RD5 Saccharomyces cerevisiae YDR348C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck potential Cdc28p substrate ZYRO0A06644g similar to uniprot|P10662 Saccharomyces cerevisiae YDR347W MRP1 Mitochondrial ribosomal protein of the small subunit MRP1 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator and with PET123 encoding a small subunit mitochondrial ribosomal protein ZYRO0A06666g similar to uniprot|Q05515 Saccharomyces cerevisiae YDR346C SVF1 Protein with a potential role in cell survival pathways required for the diauxic growth shift expression in mammalian cells increases survival under conditions inducing apoptosis ZYRO0A06688g highly similar to uniprot|P39003 Saccharomyces cerevisiae YDR343C HXT6 High-affinity glucose transporter of the major facilitator superfamily nearly identical to Hxt7p expressed at high basal levels relative to other HXTs repression of expression by high glucose requires SNF3 ZYRO0A06710g highly similar to uniprot|Q05506 Saccharomyces cerevisiae YDR341C Cytoplasmic arginyl-tRNA synthetase ZYRO0A06754g highly similar to uniprot|Q05498 Saccharomyces cerevisiae YDR339C Protein required for cell viability ZYRO0A06776g similar to uniprot|P38806 Saccharomyces cerevisiae YHR090C YNG2 Yeast homolog of mammalian Ing1 NuA4 histone acetyltransferase complex component ZYRO0A06798g similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Hypothetical ORF ZYRO0A06820g weakly similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W ZYRO0A06842g similar to uniprot|P21771 Saccharomyces cerevisiae YDR337W MRPS28 Mitochondrial ribosomal protein of the small subunit ZYRO0A06864g some similarities with uniprot|P28007 Saccharomyces cerevisiae YHR089C GAR1 Protein component of the H/ACA snoRNP pseudouridylase complex involved in the modification and cleavage of the 18S pre-rRNA ZYRO0A06886g similar to uniprot|Q05473 Saccharomyces cerevisiae YDR336W Hypothetical ORF ZYRO0A06908g highly similar to uniprot|P52918 Saccharomyces cerevisiae YDR335W MSN5 Karyopherin involved in nuclear import and export shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p Far1p and Pho4p cargo dissociation involves binding to RanGTP ZYRO0A06930g highly similar to uniprot|P38805 Saccharomyces cerevisiae YHR088W RPF1 Nucleolar protein involved in the assembly of the large ribosomal subunit contains a sigma(70)-like motif which is thought to bind RNA ZYRO0A06952g no similarity ZYRO0A06974g similar to uniprot|P38804 Saccharomyces cerevisiae YHR087W Hypothetical ORF ZYRO0A06996g some similarities with gnl|GLV|CAGL0M01188g Candida glabrata CAGL0M01188g and some similarites with uniprot|Q05471 Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase component of the SWR1 complex required for the incorporation of Htz1p into chromatin ZYRO0A07018g some similarities with uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein component of the U1 snRNP protein mutants are defective in meiotic recombination and in formation of viable spores involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA ZYRO0A07040g similar to uniprot|P30775 Saccharomyces cerevisiae YGL143C MRF1 Mitochondrial polypeptide chain release factor involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation lack of MRF1 causes mitochondrial genome instability ZYRO0A07062g highly similar to uniprot|P06242 Saccharomyces cerevisiae YDL108W KIN28 Serine/threonine protein kinase subunit of the transcription factor TFIIH involved in transcription initiation at RNA polymerase II promoters ZYRO0A07084g conserved hypothetical protein ZYRO0A07106g similar to uniprot|P40990 Saccharomyces cerevisiae YDL107W MSS2 Peripherally bound inner membrane protein of the mitochondrial matrix required for export of C-terminal tail of Cox2p through the inner membrane ZYRO0A07128g similar to uniprot|P30777 Saccharomyces cerevisiae YGL142C GPI10 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis putative alpha 1 2 mannosyltransferase required for addition of the third mannose onto the GPI core structure human PIG-Bp is a functional homolog ZYRO0A07150g similar to uniprot|P53119 Saccharomyces cerevisiae YGL141W ZYRO0A07172g similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Suppressor of SHR3 confers leflunomide resistance when overexpressed (putative) involved in ER functions ZYRO0A07194g similar to uniprot|P07269 Saccharomyces cerevisiae YDL106C PHO2 Homeobox transcription factor regulatory targets include genes involved in phosphate metabolism binds cooperatively with Pho4p to the PHO5 promoter phosphorylation of Pho2p facilitates interaction with Pho4p ZYRO0A07216g similar to uniprot|P47771 Saccharomyces cerevisiae YMR170c ALD5 and similar to uniprot|P54114 Saccharomyces cerevisiae YMR169c ALD4 ZYRO0A07238g similar to uniprot|P47771 Saccharomyces cerevisiae YMR170C ALD2 Cytosolic aldehyde dehydrogenase that uses NAD as the preferred coenzyme expression is induced in response to high osmotic stress ZYRO0A07260g similar to uniprot|P40969 Saccharomyces cerevisiae YMR168C CEP3 Essential kinetochore protein component of the CBF3 complex that binds the CDEIII region of the centromere contains an N-terminal Zn2Cys6 type zinc finger domain a C-terminal acidic domain and a putative coiled coil dimerization domain ZYRO0A07282g similar to uniprot|Q2I041 Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis postmeiotic segregation and spore viability forms a complex with Pms1p and Msh2p to repair mismatched DNA human homolog is associated with hereditary non-polyposis colon cancer ZYRO0A07304g similar to uniprot|P43124 Saccharomyces cerevisiae YDL105W NSE4 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex ZYRO0A07326g similar to uniprot|P43122 Saccharomyces cerevisiae YDL104C ZYRO0A07348g similar to uniprot|Q03829 Saccharomyces cerevisiae YMR166C ZYRO0A07370g similar to uniprot|P32567 Saccharomyces cerevisiae YMR165C SMP2 Protein involved in respiration and plasmid maintenance ZYRO0A07392g some similarities with uniprot|Q03825 Saccharomyces cerevisiae YMR164C ZYRO0A07436g weakly similar to uniprot|Q03824 Saccharomyces cerevisiae YMR163C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0A07458g highly similar to gnl|GLV|CAGL0L07370g Candida glabrata CAGL0L07370g and similar to uniprot|P43123 Saccharomyces cerevisiae YDL103C QRI1 UDP-N-acetylglucosamine pyrophosphorylase catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc) which is important in cell wall biosynthesis protein N- glycosylation and GPI anchor biosynthesis ZYRO0A07480g similar to uniprot|Q12674 Saccharomyces cerevisiae YMR162C DNF3 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the trans-Golgi likely involved in protein transport ZYRO0A07502g similar to uniprot|P48353 Saccharomyces cerevisiae YMR161W ZYRO0A07524g highly similar to uniprot|P15436 Saccharomyces cerevisiae YDL102W CDC2 Catalytic subunit of DNA polymerase delta required for chromosomal DNA replication during mitosis and meiosis intragenic recombination repair of double strand DNA breaks and DNA replication during nucleotide excision repair (NER) ZYRO0A07546g highly similar to uniprot|P39009 Saccharomyces cerevisiae YDL101C DUN1 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes phosphorylation of Rad55p and Sml1p and transient G2/M arrest after DNA damage also regulates postreplicative DNA repair ZYRO0A07568g similar to uniprot|Q03823 Saccharomyces cerevisiae YMR160W Hypothetical ORF ZYRO0A07590g similar to uniprot|Q03818 Saccharomyces cerevisiae YMR159C ATG16 Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre-autophagosomal structure essential for autophagy ZYRO0A07634g highly similar to uniprot|Q12154 Saccharomyces cerevisiae YDL100C ARR4 ATPase involved in resistance to heat and metal stress active as a dimer normally localized to the cytosol but appears to localize to late endosomes under stress conditions ZYRO0A07656g weakly similar to uniprot|Q12191 Saccharomyces cerevisiae YDL099W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0A07678g highly similar to uniprot|Q03799 Saccharomyces cerevisiae YMR158W MRPS8 Mitochondrial ribosomal protein of the small subunit ZYRO0A07700g similar to uniprot|Q03798 Saccharomyces cerevisiae YMR157C FMP39 The authentic non-tagged protein was localized to the mitochondria ZYRO0A07722g similar to uniprot|Q12368 Saccharomyces cerevisiae YDL098C SNU23 23 kD U4/U6.U5 snRNP associated protein Putative RNA binding zinc finger protein ZYRO0A07744g similar to uniprot|Q03796 Saccharomyces cerevisiae YMR156C TPP1 DNA 3'-phosphatase that functions in the repair of endogenous DNA damage functionally redundant with Apn1p and Apn2p ZYRO0A07766g highly similar to uniprot|Q12377 Saccharomyces cerevisiae YDL097C RPN6 Essential non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome the human homolog (S9 protein) partially rescues Rpn6p depletion ZYRO0A07788g similar to uniprot|P33775 Saccharomyces cerevisiae YDL095W PMT1 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway acts in complex with Pmt2p dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase ZYRO0A07810g some similarities with uniprot|Q03795 Saccharomyces cerevisiae YMR155W Hypothetical ORF ZYRO0A07854g similar to uniprot|P38985 Saccharomyces cerevisiae YDL092W SRP14 Signal recognition particle subunit ZYRO0A07876g similar to uniprot|Q12229 YDL091c Saccharomyces cerevisiae UBX3 UBX domain-containing protein that interacts with Cdc48p ZYRO0A07898g similar to uniprot|P22007 Saccharomyces cerevisiae YDL090C RAM1 essential for processing of ras proteins beta subunit of farnesyltransferase ZYRO0A07920g similar to uniprot|Q03792 Saccharomyces cerevisiae YMR154C ZYRO0A07942g weakly similar to uniprot|Q12066 Saccharomyces cerevisiae YDL089W Protein of unknown function interacts with meiotic division protein Csm1p green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery potential Cdc28p substrate ZYRO0A07964g similar to gnl|GLV|KLLA0F07227g Kluyveromyces lactis KLLA0F07227g and weakly similar to uniprot|Q05166 Saccharomyces cerevisiae YDL088C ASM4 Nuclear pore complex subunit part of a subcomplex also containing Nup53p Nup170p and Pse1p ZYRO0A07986g similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W YIM1 Mitochondrial inner membrane protease ZYRO0A08008g highly similar to uniprot|Q07508 Saccharomyces cerevisiae YDL087C LUC7 Essential protein associated with the U1 snRNP complex splicing factor involved in recognition of 5' splice site ZYRO0A08030g similar to uniprot|Q03085 Saccharomyces cerevisiae YPL033C Hypothetical ORF ZYRO0A08052g similar to uniprot|P28627 Saccharomyces cerevisiae YMR150c IMP1 protease, mitochondrial ZYRO0A08074g similar to uniprot|Q02795 Saccharomyces cerevisiae YMR149W SWP1 oligosaccharyl transferase glycoprotein complex delta subunit ZYRO0A08096g some similarities with uniprot|P40219 Saccharomyces cerevisiae YMR148W Hypothetical ORF ZYRO0A08118g some similarities with uniprot|P40218 Saccharomyces cerevisiae YMR147W Hypothetical ORF ZYRO0A08140g some similarities with uniprot|Q03083 Saccharomyces cerevisiae YPL034W Hypothetical ORF ZYRO0A08162g similar to uniprot|Q07505 Saccharomyces cerevisiae YDL086W ZYRO0A08184g highly similar to uniprot|P40217 Saccharomyces cerevisiae YMR146C TIF34 Subunit of the core complex of translation initiation factor 3(eIF3) which is essential for translation ZYRO0A08206g highly similar to uniprot|Q08911 Saccharomyces cerevisiae YOR388C FDH1 NAD()-dependent formate dehydrogenase may protect cells from exogenous formate ZYRO0A08228g similar to uniprot|P40215 Saccharomyces cerevisiae YMR145C NDE1 Mitochondrial external NADH dehydrogenase ZYRO0A08250g no similarity ZYRO0A08272g highly similar to uniprot|Q07478 Saccharomyces cerevisiae YDL084W SUB2 Suppresses the cold-sensitive snRNP biogenesis brr1-1 mutation RNA helicase ZYRO0A08294g some similarities with uniprot|P40214 Saccharomyces cerevisiae YMR144W Hypothetical ORF ZYRO0A08316g highly similar to uniprot|P40213 Saccharomyces cerevisiae YMR143w RPS16A or uniprot|P40213 Saccharomyces cerevisiae YDL083c RPS16B ZYRO0A08338g highly similar to uniprot|Q12690 Saccharomyces cerevisiae YDL082w RPL13A ribosomal protein or uniprot|P40212 Saccharomyces cerevisiae YMR142c RPL13B ZYRO0A08360g highly similar to uniprot|P05318 Saccharomyces cerevisiae YDL081C RPP1A Ribosomal protein P1 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component ZYRO0A08382g similar to uniprot|P40210 Saccharomyces cerevisiae YMR140W SIP5 Sip5p facilitates the interaction between the Glc7p phosphatase and the Snf1p kinase ZYRO0A08404g weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine ZYRO0A08426g similar to uniprot|Q07471 Saccharomyces cerevisiae YDL080C THI3 Probable decarboxylase required for expression of enzymes involved in thiamine biosynthesis may have a role in catabolism of amino acids to long-chain and complex alcohols ZYRO0A08448g highly similar to uniprot|P38615 Saccharomyces cerevisiae YMR139W RIM11 Protein kinase required for signal transduction during entry into meiosis ZYRO0A08470g similar to uniprot|P32419 Saccharomyces cerevisiae YDL078C MDH3 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the glyoxylate cycle ZYRO0A08492g similar to uniprot|P39110 Saccharomyces cerevisiae YMR138W CIN4 GTP-binding protein involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl ZYRO0A08514g similar to uniprot|Q759M6 Ashbya gossypii ADR250C ADR250Cp and weakly similar to YMR137C uniprot|P30620 Saccharomyces cerevisiae YMR137C PSO2 Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives induced by UV-irradiation ZYRO0A08536g weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 ZYRO0A08558g similar to uniprot|P40208 Saccharomyces cerevisiae YMR135C GID8 Protein of unknown function involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains LisH and CTLH domains like Vid30p ZYRO0A08580g similar to uniprot|P40207 Saccharomyces cerevisiae YMR134W Protein required for cell viability ZYRO0A08602g no similarity ZYRO0A08624g some similarities with uniprot|Q07988 Saccharomyces cerevisiae YLR040C Hypothetical ORF ZYRO0A08646g some similarities with uniprot|P32841 Saccharomyces cerevisiae YMR133W REC114 Protein involved in early stages of meiotic recombination ZYRO0A08668g similar to uniprot|P40206 Saccharomyces cerevisiae YMR132C JLP2 Hypothetical ORF ZYRO0A08690g highly similar to uniprot|Q04225 Saccharomyces cerevisiae YMR131C RRB1 RiboSome Assembly 2 ZYRO0A08712g similar to uniprot|P40395 Saccharomyces cerevisiae YLR039C RIC1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p involved in transcription of ribosomal protein genes and ribosomal RNA ZYRO0A08734g highly similar to uniprot|Q01519 Saccharomyces cerevisiae YLR038C COX12 Subunit VIb of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain required for assembly of fully active cytochrome c oxidase but not required for activity after assembly ZYRO0A08778g similar to uniprot|Q04223 Saccharomyces cerevisiae YMR130W Hypothetical ORF ZYRO0A08800g some similarities with uniprot|Q07980 Saccharomyces cerevisiae YLR035C MLH2 Protein required for DNA mismatch repair in mitosis and meiosis involved in the repair of mutational intermediates forms a complex with Pms1p and Msh1p to repair mismatched DNA ZYRO0A08822g similar to uniprot|P39685 Saccharomyces cerevisiae YMR129W POM152 Nuclear pore membrane glycoprotein may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase ZYRO0A08844g highly similar to uniprot|Q12078 Saccharomyces cerevisiae YLR034C SMF3 Putative metal transporter Nramp homolog homolog of SMF1 and SMF2 ZYRO0A08866g similar to uniprot|Q07979 Saccharomyces cerevisiae YLR033W RSC58 ZYRO0A08888g similar to uniprot|Q04217 Saccharomyces cerevisiae YMR128W ECM16 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP predominantly nucleolar in distribution required for 18S rRNA synthesis ZYRO0A08910g similar to uniprot|P40963 Saccharomyces cerevisiae YMR127C SAS2 Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p) which acetylates free histones and nucleosomes and regulates transcriptional silencing member of the MYSTacetyltransferase family ZYRO0A08932g similar to uniprot|P32849 Saccharomyces cerevisiae YLR032W RAD5 Single-stranded DNA-dependent ATPase involved in postreplication repair contains RING finger domain ZYRO0A08954g similar to uniprot|Q04216 Saccharomyces cerevisiae YMR126C DLT1 Protein of unknown function deletion causes sensitivity to thermal stress ZYRO0A08976g similar to uniprot|P34160 Saccharomyces cerevisiae YMR125W STO1 Large subunit of the nuclear mRNA cap-binding protein complex interacts with Npl3p to carry poly(A) mRNA from the nucleus to the cytoplasm also involved in mRNA degradation in the nucleus orthologous to mammalian CBP80 ZYRO0A08998g weakly similar to uniprot|P39523 Saccharomyces cerevisiae YMR124W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck ZYRO0A09020g similar to uniprot|Q03880 Saccharomyces cerevisiae YMR123W PKR1 Protein of unknown function overproduction confers resistance to Pichia farinosa killer toxin ZYRO0A09042g some similarities with uniprot|Q3E842 Saccharomyces cerevisiae YMR122W-A ZYRO0A09086g no similarity ZYRO0A09108g highly similar to uniprot|P54780 Saccharomyces cerevisiae RPL15B and to uniprot|P05748 Saccharomyces cerevisiae YLR029C RPL15A ZYRO0A09130g highly similar to uniprot|P38009 Saccharomyces cerevisiae YMR120C ADE17 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities isozyme of Ade16p ade16 ade17 mutants require adenine and histidine ZYRO0A09152g similar to uniprot|P54074 Saccharomyces cerevisiae YMR119W ASI1 Putative integral membrane E3 ubiquitin ligase genetic interactions suggest a role in negative regulation of amino acid uptake ZYRO0A09196g highly similar to uniprot|P32473 Saccharomyces cerevisiae YBR221C ZYRO0A09218g similar to uniprot|P38318 Saccharomyces cerevisiae YBR220C Hypothetical ORF ZYRO0A09240g weakly similar to uniprot|P53012 Saccharomyces cerevisiae YGL126W SCS3 Protein required for inositol prototrophy ZYRO0A09262g similar to uniprot|P38633 Saccharomyces cerevisiae YGL127C SOH1 Protein with sequence similarity to RNA polymerases; interacts with a DNA repair protein, Rad5p, in the two-hybrid system; may provide a link between recombination in direct repeats and transcription ZYRO0A09284g similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression ZYRO0A09306g highly similar to uniprot|P19073 Saccharomyces cerevisiae YLR229C CDC42 Small rho-like GTPase essential for establishment and maintenance of cell polarity mutants have defects in the organization of actin and septins ZYRO0A09328g highly similar to uniprot|P12612 Saccharomyces cerevisiae YDR212W TCP1 tailless complex polypeptide 1 chaperonin subunit alpha ZYRO0A09350g similar to gnl|GLV|KLLA0A04169g Kluyveromyces lactis KLLA0A04169g and some similarites with YDR213W uniprot|Q12151 Saccharomyces cerevisiae YDR213W UPC2 involved in sterol uptake zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type ZYRO0A09372g similar to uniprot|Q7LIE3 Saccharomyces cerevisiae YDR214W AHA1 Activator of Heat Shock Protein 90 ATPase ZYRO0A09394g conserved hypothetical protein ZYRO0A09416g similar to uniprot|P07248 Saccharomyces cerevisiae YDR216W ADR1 Positive transcriptional regulator controls the expression of ADH2 peroxisomal protein genes and genes required for ethanol glycerol and fatty acid utilization ZYRO0A09438g weakly similar to uniprot|P14737 Saccharomyces cerevisiae YDR217C RAD9 DNA damage-dependent checkpoint protein required for cell-cycle arrest in G1/S intra-S and G2/M transmits checkpoint signal by activating Rad53p and Chk1p hyperphosphorylated by Mec1p and Tel1p potential Cdc28p substrate ZYRO0A09460g weakly similar to uniprot|Q05955 Saccharomyces cerevisiae YLR227C ADY4 Component of the meiotic outer plaque a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane ZYRO0A09482g similar to uniprot|Q04921 Saccharomyces cerevisiae YDR218C SPR28 Septin-related protein expressed during sporulation ZYRO0A09504g similar to uniprot|Q05949 Saccharomyces cerevisiae YLR226W BUR2 Cyclin for the Sgv1p (Bur1p) protein kinase Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II ZYRO0A09526g weakly similar to uniprot|Q04922 Saccharomyces cerevisiae YDR219C Hypothetical ORF ZYRO0A09548g weakly similar to uniprot|Q04924 Saccharomyces cerevisiae YDR221W Hypothetical ORF ZYRO0A09570g similar to uniprot|Q05948 Saccharomyces cerevisiae YLR225C Hypothetical ORF ZYRO0A09592g weakly similar to uniprot|Q05947 Saccharomyces cerevisiae YLR224W Hypothetical ORF ZYRO0A09614g weakly similar to uniprot|P39520 Saccharomyces cerevisiae YLR223C IFH1 Essential protein with a highly acidic N-terminal domain IFH1 exhibits genetic interactions with FHL1 overexpression interferes with silencing at telomeres and HM loci potential Cdc28p substrate ZYRO0A09636g highly similar to uniprot|Q05946 Saccharomyces cerevisiae YLR222C UTP13 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0A09658g some similarities with uniprot|Q05942 Saccharomyces cerevisiae YLR221C RSA3 Protein with a likely role in ribosomal maturation required for accumulation of wild-type levels of large (60S) ribosomal subunits binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus ZYRO0A09680g highly similar to uniprot|Q74ZL6 Ashbya gossypii AGR182C AGR182Cp and similar to YLR220W uniprot|P47818 Saccharomyces cerevisiae YLR220W CCC1 Functions in the homeostasis of both calcium and manganese ions Possible transmembrane Ca2 transporter ZYRO0A09702g similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation ZYRO0A09724g similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p ZYRO0A09768g some similarities with uniprot|Q05812 Saccharomyces cerevisiae YLR219W MSC3 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery msc3 mutants are defective in directing meiotic recombination events to homologous chromatids ZYRO0A09790g some similarities with uniprot|P11978 Saccharomyces cerevisiae YDR227W SIR4 Silent information regulator that together with SIR2 and SIR3 is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci potentially phosphorylated by Cdc28p some alleles of SIR4 prolong lifespan ZYRO0A09812g some similarities with gnl|GLV|DEHA0A12507g Debaryomyces hansenii DEHA0A12507g ZYRO0A09834g similar to uniprot|P39081 Saccharomyces cerevisiae YDR228C PCF11 mRNA 3' end processing factor essential component of cleavage and polyadenylation factor IA (CF IA) involved in pre-mRNA 3' end processing and in transcription termination binds C-terminal domain of largest subunit of RNA pol II (Rpo21p) ZYRO0A09856g highly similar to uniprot|P38988 Saccharomyces cerevisiae YDL198C GGC1 Mitochondrial GTP/GDP transporter essential for mitochondrial genome maintenance has a role in mitochondrial iron transport member of the mitochondrial carrier family (putative) mitochondrial carrier protein ZYRO0A09878g conserved hypothetical protein ZYRO0A09900g similar to uniprot|P26188 Saccharomyces cerevisiae YDL200c, DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage ZYRO0A09922g highly similar to uniprot|Q12009 Saccharomyces cerevisiae YDL201W TRM8 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA ZYRO0A09944g similar to uniprot|P36521 Saccharomyces cerevisiae YDL202W MRPL11 Mitochondrial ribosomal protein of the large subunit ZYRO0A09966g similar to uniprot|Q04934 Saccharomyces cerevisiae YDR229W IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p may partially counteract the action of Vps33p and vice versa localizes to the rim of the vacuole as cells approach stationary phase ZYRO0A09988g similar to uniprot|Q04935 Saccharomyces cerevisiae YDR231C COX20 Mitochondrial inner membrane protein required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase ZYRO0A10010g similar to uniprot|Q07622 Saccharomyces cerevisiae YDL203C Hypothetical ORF ZYRO0A10032g highly similar to gnl|GLV|KLLA0C15059g Kluyveromyces lactis KLLA0C15059g and similar to YDR232W uniprot|P09950 Saccharomyces cerevisiae YDR232W HEM1 5- aminolevulinate synthase catalyzes the first step in the heme biosynthetic pathway an N-terminal signal sequence is required for localization to the mitochondrial matrix expression is regulated by Hap2p-Hap3p ZYRO0A10054g some similarities with uniprot|Q04947 Saccharomyces cerevisiae YDR233C RTN1 reticulon gene member of the RTNLA (reticulon-like A) subfamily ZYRO0A10076g similar to uniprot|P49367 Saccharomyces cerevisiae YDR234W LYS4 Homoaconitase catalyzes the conversion of homocitrate to homoisocitrate which is a step in the lysine biosynthesis pathway ZYRO0A10098g similar to uniprot|P28789 Saccharomyces cerevisiae YDL205C HEM3 Phorphobilinogen deaminase catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane the third step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus expression is regulated by Hap2p-Hap3p ZYRO0A10120g similar to uniprot|Q03776 Saccharomyces cerevisiae YDR235W PRP42 U1 snRNP protein involved in splicing required for U1 snRNP biogenesis contains multiple tetriatricopeptide repeats ZYRO0A10142g similar to gnl|GLV|KLLA0C15191g Kluyveromyces lactis KLLA0C15191g and weakly similar to uniprot|Q12424 Saccharomyces cerevisiae YDL206W Hypothetical ORF ZYRO0A10164g similar to uniprot|Q03778 Saccharomyces cerevisiae YDR236C FMN1 Riboflavin kinase phosphorylates riboflavin to form riboflavin monophosphate (FMN) which is a necessary cofactor for many enzymes localizes to microsomes and to the mitochondrial inner membrane ZYRO0A10186g some similarities with uniprot|Q12315 Saccharomyces cerevisiae YDL207W GLE1 Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import component of Nup82p nuclear pore subcomplex contains a nuclear export signal ZYRO0A10208g similar to uniprot|P36519 Saccharomyces cerevisiae YDR237W MRPL7 Mitochondrial ribosomal protein of the large subunit ZYRO0A10230g similar to uniprot|P53305 Saccharomyces cerevisiae YGR215W RSM27 Mitochondrial ribosomal protein of the small subunit ZYRO0A10252g similar to uniprot|P53306 Saccharomyces cerevisiae YGR216C GPI1 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol ZYRO0A10274g similar to uniprot|P50077 Saccharomyces cerevisiae YGR217W CCH1 Voltage-gated calcium channel involved in calcium influx in response to mating pheromones ZYRO0A10296g similar to uniprot|Q02979 Saccharomyces cerevisiae YPL110C Hypothetical ORF ZYRO0A10318g similar to uniprot|Q02981 Saccharomyces cerevisiae YPL109C Hypothetical ORF ZYRO0A10340g highly similar to uniprot|P38116 Saccharomyces cerevisiae YBR164C ARL1 Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor ZYRO0A10362g similar to gnl|GLV|CAGL0I10813g Candida glabrata CAGL0I10813g and some similarities with uniprot|P38290 Saccharomyces cerevisiae YBR165W UBS1 Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity ZYRO0A10384g similar to uniprot|P20049 Saccharomyces cerevisiae YBR166C TYR1 Step of tyrosine biosynthesis pathway Prephenate dehydrogenase (NADP) ZYRO0A10406g similar to uniprot|P32459 Saccharomyces cerevisiae YIR032C DAL3 Ureidoglycolate hydrolase converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation expression sensitive to nitrogen catabolite repression ZYRO0A10428g similar to uniprot|Q02872 Saccharomyces cerevisiae YPL108W Hypothetical ORF ZYRO0A10450g similar to uniprot|P38291 Saccharomyces cerevisiae YBR167C POP7 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends ZYRO0A10472g similar to uniprot|P38292 Saccharomyces cerevisiae YBR168W PEX32 Peroxisomal integral membrane protein involved in negative regulation of peroxisome size partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p ZYRO0A10494g similar to uniprot|Q02873 Saccharomyces cerevisiae YPL107W Hypothetical ORF ZYRO0A10516g highly similar to uniprot|P32589 Saccharomyces cerevisiae YPL106C SSE1 HSP70 family member highly homologous to Ssa1p and Sse2p ZYRO0A10538g similar to uniprot|P36062 Saccharomyces cerevisiae YKL146W AVT3 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ZYRO0A10560g highly similar to uniprot|P33299 Saccharomyces cerevisiae YKL145W RPT1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for optimal CDC20 transcription interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p ZYRO0A10582g highly similar to uniprot|P35718 Saccharomyces cerevisiae YKL144C RPC25 RNA polymerase III subunit C25 ZYRO0A10604g similar to uniprot|P34078 Saccharomyces cerevisiae YKL143W LTV1 Protein required for growth at low temperature ZYRO0A10626g similar to uniprot|P35719 Saccharomyces cerevisiae YKL142W ZYRO0A10648g highly similar to uniprot|P47077 Saccharomyces cerevisiae YJL010C Protein required for cell viability ZYRO0A10670g highly similar to uniprot|P47079 Saccharomyces cerevisiae YJL008C CCT8 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo ZYRO0A10714g similar to uniprot|P47061 Saccharomyces cerevisiae YJL029C VPS53 Required for Vacuolar Protein Sorting Vps53p is a hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p. ZYRO0A10736g highly similar to uniprot|P40958 Saccharomyces cerevisiae YJL030W MAD2 Component of the spindle-assembly checkpoint complex which delays the onset of anaphase in cells with defects in mitotic spindle assembly forms a complex with Mad1p ZYRO0A10758g highly similar to uniprot|Q00618 Saccharomyces cerevisiae YJL031C BET4 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p ZYRO0A10780g similar to uniprot|P46962 Saccharomyces cerevisiae YJL006C ZYRO0A10802g similar to uniprot|P20448 Saccharomyces cerevisiae YJL033W HCA4 Putative nucleolar DEAD box RNA helicase high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis ZYRO0A10824g similar to uniprot|Q07930 Saccharomyces cerevisiae YLR016C Hypothetical ORF ZYRO0A10846g highly similar to uniprot|P16474 Saccharomyces cerevisiae YJL034W KAR2 ATPase involved in protein import into the ER also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins regulates the unfolded protein response via interaction with Ire1p ZYRO0A10868g no similarity ZYRO0A10890g similar to uniprot|P47058 Saccharomyces cerevisiae YJL035C TAD2 tRNA-specific adenosine-34 deaminase subunit Tad2p ZYRO0A10912g highly similar to uniprot|P47057 Saccharomyces cerevisiae YJL036W SNX4 Sorting NeXin ZYRO0A10934g similar to YLR015W, uniprot|P43132 Saccharomyces cerevisiae YLR015W (BRE2) ZYRO0A10956g similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain positively regulates transcription of genes involved in uracil biosynthesis activity may be modulated by interaction with Tup1p ZYRO0A11000g highly similar to uniprot|Q07748 Saccharomyces cerevisiae YDL244W THI13 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP) member of a subtelomeric gene family including THI5 THI11 THI12 and THI13 ZYRO0A11022g no similarity ZYRO0A11044g conserved hypothetical protein ZYRO0A11066g similar to uniprot|Q07915 Saccharomyces cerevisiae YLR009W RLP24 Ribosomal Like Protein 24 ZYRO0A11088g similar to uniprot|Q07914 Saccharomyces cerevisiae YLR008C PAM18 Constituent of the mitochondrial import motor associated with the presequence translocase along with Ssc1p Tim44p Mge1p and Pam16p stimulates the ATPase activity of Ssc1p to drive mitochondrial import contains a J domain ZYRO0A11110g similar to uniprot|Q07913 Saccharomyces cerevisiae YLR007W NSE1 Essential nuclear protein required for DNA repair forms a complex with Smc5p and Rhc18p ZYRO0A11132g some similarities with uniprot|Q22X91 Tetrahymena thermophila SB210 TTHERM_00561660 Viral A-type inclusion protein repeat containing protein ZYRO0A11154g similar to uniprot|Q07084 Saccharomyces cerevisiae YLR006C SSK1 Cytoplasmic response regulator part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism dephosphorylated form is degraded by the ubiquitin-proteasome system potential Cdc28p substrate ZYRO0A11176g highly similar to uniprot|Q04673 YLR005W Saccharomyces cerevisiae SSL1 Component of RNA polymerase transcription factor TFIIH ZYRO0A11198g no similarity ZYRO0A11242g no similarity ZYRO0A11286g no similarity ZYRO0A11308g no similarity ZYRO0A11352g no similarity ZYRO0A11374g no similarity ZYRO0A11396g similar to uniprot|Q07904 Saccharomyces cerevisiae YLR004C Hypothetical ORF ZYRO0A11418g similar to Q07897 YLR003C uniprot|Q07897 Saccharomyces cerevisiaeCMS1 Hypothetical ORF ZYRO0A11440g similar to uniprot|P27351 Saccharomyces cerevisiae YJR005W APL1 beta-adaptin large subunit of the clathrin-associated protein complex ZYRO0A11462g some similarities with uniprot|P20840 Saccharomyces cerevisiae YJR004C SAG1 Alpha-agglutinin of alpha-cells binds to Aga1p during agglutination N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin C-terminal half is highly glycosylated and contains GPI anchor ZYRO0A11484g weakly similar to uniprot|O00026 Saccharomyces cerevisiae YOR066W Protein of unknown function potential Cdc28p substrate ZYRO0A11506g highly similar to uniprot|P40351 Saccharomyces cerevisiae YOR067C ALG8 adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein glycosyl transferase ZYRO0A11528g similar to uniprot|Q92331 Saccharomyces cerevisiae YOR069W VPS5 Component of the retromer coat that retrieves proteins from late endosomes sorting nexin I homolog ZYRO0A11550g similar to uniprot|P36159 Saccharomyces cerevisiae YKR079C TRZ1 Protein required for cell viability ZYRO0A11572g similar to uniprot|Q08484 Saccharomyces cerevisiae YOR070C GYP1 Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p Sec4p Ypt7p and Ypt51p (in vitro) involved in vesicle docking and fusion ZYRO0A11594g highly similar to uniprot|Q02046 Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5 10-methylenetetrahydrafolate dehydrogenase plays a catalytic role in oxidation of cytoplasmic one-carbon units expression is regulated by Bas1p and Bas2p repressed by adenine and may be induced by inositol and choline ZYRO0A11616g highly similar to uniprot|P36160 Saccharomyces cerevisiae YKR081C RPF2 ZYRO0A11638g similar to uniprot|P36161 Saccharomyces cerevisiae YKR082W NUP133 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) localizes to both sides of the NPC required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p ZYRO0A11660g similar to uniprot|P36162 Saccharomyces cerevisiae YKR083C DAD2 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore ZYRO0A11682g similar to uniprot|Q08490 Saccharomyces cerevisiae YOR073W SGO1 Component of the spindle checkpoint involved in sensing lack of tension on mitotic chromosomes protects centromeric Rec8p at meiosis I required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability ZYRO0A11704g highly similar to uniprot|P06785 Saccharomyces cerevisiae YOR074C CDC21 Thymidylate synthase required for de novo biosynthesis of pyrimidine deoxyribonucleotides expression is induced at G1/S ZYRO0A11726g similar to uniprot|P41834 Saccharomyces cerevisiae YOR075W UFE1 t-SNARE that resides on the endoplasmic reticulum and mediates retrograde traffic from the Golgi complex potential Cdc28p substrate endoplasmic reticulum t-SNARE coprecipitates with Sec20p Tip1p. and Sec22p ZYRO0A11748g similar to uniprot|P32769 Saccharomyces cerevisiae YKR084C HBS1 GTP binding protein ZYRO0A11770g conserved hypothetical protein ZYRO0A11792g similar to uniprot|P22354 Saccharomyces cerevisiae YKR085C MRPL20 Mitochondrial ribosomal protein of the large subunit ZYRO0A11814g similar to uniprot|P15938 Saccharomyces cerevisiae YKR086W PRP16 RNA helicase in the DEAH-box family involved in the second catalytic step of splicing exhibits ATP-dependent RNA unwinding activity ZYRO0A11836g similar to uniprot|P36163 Saccharomyces cerevisiae YKR087C OMA1 Metalloendopeptidase of the mitochondrial inner membrane involved in turnover of membrane-embedded proteins member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes ZYRO0A11858g similar to uniprot|Q759P8 Ashbya gossypii ADR225W ADR225Wp and weakly similar to YOR077W uniprot|P40962 Saccharomyces cerevisiae ZYRO0A11880g similar to uniprot|P36164 Saccharomyces cerevisiae YKR088C TVP38 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0A11902g conserved hypothetical protein ZYRO0A11924g some similarities with uniprot|P38276 Saccharomyces cerevisiae YBR137W Hypothetical ORF ZYRO0A11968g similar to uniprot|P53210 Saccharomyces cerevisiae YGR017W Hypothetical ORF ZYRO0A11990g highly similar to uniprot|P17649 Saccharomyces cerevisiae YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways required for normal oxidative stress tolerance and nitrogen utilization ZYRO0A12012g some similarities with uniprot|Q12114 Saccharomyces cerevisiae YLR330W CHS5 Protein of unknown function involved in chitin biosynthesis by regulating Chs3p localization also involved in cell fusion during mating ZYRO0A12034g highly similar to uniprot|P39111 Saccharomyces cerevisiae YGR020C VMA7 Vacuolar H ATPase subunit F of the catalytic (V1) sector ZYRO0A12056g similar to uniprot|P53212 Saccharomyces cerevisiae YGR021W Hypothetical ORF ZYRO0A12100g some similarities with uniprot|P36027 Saccharomyces cerevisiae YLR332W MID2 Protein required for mating and to YGR023W uniprot|P53214 Saccharomyces cerevisiae YGR023W MTL1 Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone- induced morphogenesis; suppresses rgd1 null mutations ZYRO0A12144g highly similar to uniprot|P53215 Saccharomyces cerevisiae YGR024C THG1 tRNAHis guanylyltransferase adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage essential enzyme conserved among eukaryotes ZYRO0A12166g similar to uniprot|P53217 Saccharomyces cerevisiae YGR026W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery ZYRO0A12254g some similarities with uniprot|P07282 Saccharomyces cerevisiae YLR333C ZYRO0A12298g weakly similar to uniprot|P32499 Saccharomyces cerevisiae YLR335W NUP2 Protein involved in nucleocytoplasmic transport binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels also has a role in chromatin organization ZYRO0A12320g some similarities with uniprot|Q06132 Saccharomyces cerevisiae YLR336C SGD1 Suppressor of Glycerol Defect may be involved in high osmolarity signaling pathway ZYRO0A12342g highly similar to uniprot|P28737 Saccharomyces cerevisiae YGR028W MSP1 Mitochondrial protein involved in sorting of proteins in the mitochondria putative membrane-spanning ATPase ZYRO0A12364g highly similar to uniprot|P27882 Saccharomyces cerevisiae YGR029W ZYRO0A12386g weakly similar to uniprot|Q06133 Saccharomyces cerevisiae YLR337C VRP1 Involved in cytoskeletal organization and cellular growth Proline-rich protein verprolin ZYRO0A12408g conserved hypothetical protein ZYRO0A12430g similar to uniprot|P53218 Saccharomyces cerevisiae YGR030C POP6 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends ZYRO0A12452g highly similar to uniprot|P05317 Saccharomyces cerevisiae YLR340W RPP0 Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302 ZYRO0A12474g some similarities with uniprot|Q06134 Saccharomyces cerevisiae YLR341W SPO77 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis ZYRO0A12496g similar to uniprot|P53219 Saccharomyces cerevisiae YGR031W Hypothetical ORF ZYRO0A12518g highly similar to uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 Catalytic subunit of 1 3-beta-D-glucan synthase functionally redundant with alternate catalytic subunit Gsc2p binds to regulatory subunit Rho1p involved in cell wall synthesis and maintenance localizes to sites of cell wall remodeling or uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2 ZYRO0A12540g similar to uniprot|Q06135 Saccharomyces cerevisiae YLR343W GAS2 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p ZYRO0A12562g similar to uniprot|P53220 Saccharomyces cerevisiae YGR033C FMP17 The authentic non-tagged protein was localized to the mitochondria ZYRO0A12606g highly similar to uniprot|P05743 Saccharomyces cerevisiae YLR344W ZYRO0A12628g similar to uniprot|Q06137 Saccharomyces cerevisiae YLR345W Hypothetical ORF ZYRO0A12650g similar to uniprot|P53223 Saccharomyces cerevisiae YGR036C CAX4 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER cleaves the anhydride linkage in Dol-P-P required for Dol-P-P- linked oligosaccharide intermediate synthesis and protein N-glycosylation ZYRO0A12672g highly similar to uniprot|Q06142 Saccharomyces cerevisiae YLR347C KAP95 Karyopherin beta forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS) interacts with nucleoporins to guide transport across the nuclear pore complex ZYRO0A12694g highly similar to uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding protein transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes ZYRO0A12738g similar to uniprot|P53224 Saccharomyces cerevisiae YGR038W ZYRO0A12782g highly similar to uniprot|P49954 Saccharomyces cerevisiae YLR351C ZYRO0A12804g conserved hypothetical protein ZYRO0A12826g highly similar to uniprot|P14681 Saccharomyces cerevisiae YGR040W KSS1 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response ZYRO0A12848g similar to uniprot|Q06479 Saccharomyces cerevisiae YLR352W Hypothetical ORF ZYRO0A12870g some similarities with uniprot|P41698 Saccharomyces cerevisiae YLR353W BUD8 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern and bud at the proximal pole ZYRO0A12892g weakly similar to uniprot|Q75CW0 Ashbya gossypii ACL194C ACL194Cp ZYRO0A12914g highly similar to uniprot|P15019 Saccharomyces cerevisiae YLR354C TAL1 Transaldolase enzyme in the pentose phosphate pathway ZYRO0A12936g some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 mediates cell type control of sporulation negatively regulates IME1 and sporulation zinc finger protein negative regulator of meiosis directly repressed by a1-a2 regulator ZYRO0A12958g weakly similar to uniprot|P34227 Saccharomyces cerevisiae YBL064C ZYRO0A12980g similar to uniprot|P38129 Saccharomyces cerevisiae YBR198C TAF5 Subunit (90 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification ZYRO0A13002g similar to uniprot|P46961 Saccharomyces cerevisiae YPL076W GPI2 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-C protein ZYRO0A13024g some similarities with uniprot|Q02831 Saccharomyces cerevisiae YPL077C Hypothetical ORF ZYRO0A13046g highly similar to uniprot|P12709 Saccharomyces cerevisiae YBR196C PGI1 Glycolytic enzyme phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate required for cell cycle progression and completion of the gluconeogenic events of sporulation ZYRO0A13068g similar to uniprot|P13712 Saccharomyces cerevisiae YBR195C MSI1 Subunit of chromatin assembly factor I (CAF-I) regulates the RAS/cAMP pathway via sequestration of Npr1p kinase localizes to the nucleus and cytoplasm homologous to human retinoblastoma binding proteins RbAp48 and RbAp46 ZYRO0A13090g highly similar to uniprot|P05626 Saccharomyces cerevisiae YPL078C ATP4 Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis ZYRO0A13112g some similarities with uniprot|P38305 Saccharomyces cerevisiae YBR194W SOY1 Synthetic with Old Yellow Enzyme ZYRO0A13134g similar to uniprot|P38304 Saccharomyces cerevisiae YBR193C MED8 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex ZYRO0A13156g highly similar to uniprot|P38127 Saccharomyces cerevisiae YBR192W RIM2 Protein of the mitochondrial carrier (MCF) family that is required for respiration Probable carrier protein mitochondrial ZYRO0A13178g highly similar to uniprot|Q02753 Saccharomyces cerevisiae YBR191W ZYRO0A13200g highly similar to uniprot|O13516 Saccharomyces cerevisiae YPL081W RPS9A and to uniprot|P05755 Saccharomyces cerevisiae YBR189W RPS9B Proteins component of the small (40S) ribosomal subunit ZYRO0A13222g highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase ZYRO0A13244g highly similar to uniprot|P32333 Saccharomyces cerevisiae YPL082C MOT1 Essential abundant protein involved in regulation of transcription removes Spt15p (TBP) from DNA via its C-terminal ATPase activity forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity ZYRO0A13266g conserved hypothetical protein ZYRO0A13288g similar to uniprot|P38301 Saccharomyces cerevisiae YBR187W Hypothetical ORF ZYRO0A13310g similar to uniprot|P38126 Saccharomyces cerevisiae YBR186W PCH2 Nucleolar component of the pachytene checkpoint which prevents chromosome segregation when recombination and chromosome synapsis are defective also represses meiotic interhomolog recombination in the rDNA ZYRO0A13332g similar to uniprot|Q02825 Saccharomyces cerevisiae YPL083C SEN54 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p ZYRO0A13354g similar to uniprot|P48582 Saccharomyces cerevisiae YPL084W BRO1 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes ZYRO0A13376g similar to uniprot|P38300 Saccharomyces cerevisiae YBR185C MBA1 Protein involved in assembly of mitochondrial respiratory complexes may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane ZYRO0A13398g some similarities with uniprot|P48415 Saccharomyces cerevisiae YPL085W SEC16 COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes interacts with Sec23p Sec24p and Sec31p ZYRO0A13420g highly similar to uniprot|Q02908 Saccharomyces cerevisiae YPL086C ELP3 Histone acetyltransferase subunit of the Elongator complex which is a component of the RNA polymerase II holoenzyme activity is directed specifically towards histones H3 and H4 disruption confers resistance to K. lactis zymotoxin ZYRO0A13442g similar to uniprot|Q02896 Saccharomyces cerevisiae YPL087W YDC1 Yeast dihydro-ceramidase alkaline dihydroceramidase with minor reverse activity. ZYRO0A13464g some similarities with uniprot|P38128 Saccharomyces cerevisiae YBR182C SMP1 Transcription factor of the MADS (Mcm1p Agamous Deficiens SRF) box family closely related to RLM1 Probable DNA-binding transcription factor Homolog to SRF/SL-2 ZYRO0A13486g similar to uniprot|P15992 Saccharomyces cerevisiae YBR072W HSP26 Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer induced by heat upon entry into stationary phase and during sporulation ZYRO0A13530g similar to uniprot|P05066 Saccharomyces cerevisiae YOR386W PHR1 DNA photolyase involved in photoreactivation repairs pyrimidine dimers in the presence of visible light induced by DNA damage regulated by transcriptional repressor Rph1p ZYRO0A13552g similar to uniprot|Q2US70 Aspergillus oryzae AO090005000547 Predicted protein ZYRO0A13574g similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W ZYRO0A13596g similar to gnl|GLV|KLLA0D10153g Kluyveromyces lactis KLLA0D10153g and weakly similar to uniprot|P35995 Saccharomyces cerevisiae YKL222C Hypothetical ORF ZYRO0A13618g similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs ZYRO0A13640g similar to uniprot|P40582 Saccharomyces cerevisiae YIR038C GTT1 ER associated glutathione S-transferase capable of homodimerization expression induced during the diauxic shift and throughout stationary phase functional overlap with Gtt2p Grx1p and Grx2p ZYRO0A13662g some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) ZYRO0A13750g similar to uniprot|Q07904 Saccharomyces cerevisiae YLR004C Hypothetical ORF ZYRO0A13772g no similarity ZYRO0A13816g some similarities with uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance interacts with sodium:hydrogen antiporter Nha1p member of a family of conserved often subtelomerically- encoded proteins ZYRO0A13838g no similarity ZYRO0A13860g no similarity ZYRO0A13904g no similarity ZYRO0A13926g no similarity ZYRO0A13948g some similarities with uniprot|P53344 Saccharomyces cerevisiae YGR295C COS6 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins ZYRO0A13970g similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase catalyzes the third step in the biotin biosynthesis pathway BIO4 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis expression appears to be repressed at low iron levels ZYRO0A13992g similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis ZYRO0B00110g no similarity ZYRO0B00132g no similarity ZYRO0B00154g weakly similar to uniprot|P47187 Saccharomyces cerevisiae YJR161C COS5 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins ZYRO0B00176g some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments ZYRO0B00198g conserved hypothetical protein ZYRO0B00220g conserved hypothetical protein ZYRO0B00242g conserved hypothetical protein ZYRO0B00264g similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 ZYRO0B00286g conserved hypothetical protein ZYRO0B00308g conserved hypothetical protein ZYRO0B00330g similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W ZYRO0B00396g similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family ZYRO0B00418g highly similar to uniprot|P23641 Saccharomyces cerevisiae YJR077C MIR1 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Pic2p but more abundant than Pic2 under normal conditions ZYRO0B00462g highly similar to uniprot|Q06703 Saccharomyces cerevisiae YLR308W CDA2 Chitin deacetylase together with Cda1p involved in the biosynthesis ascospore wall component chitosan required for proper rigidity of the ascospore wall ZYRO0B00484g similar to uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport mediates transport between an endosomal compartment and the Golgi contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi ZYRO0B00506g similar to uniprot|P04821 Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP required for progression through G1 ZYRO0B00528g highly similar to uniprot|P29055 Saccharomyces cerevisiae YPR086W SUA7 Transcription factor TFIIB a general transcription factor required for transcription initiation and start site selection by RNA polymerase II ZYRO0B00550g highly similar to uniprot|P04802 Saccharomyces cerevisiae YLL018C DPS1 Cytoplasmic aspartyl-tRNA synthetase homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp) class II aminoacyl tRNA synthetase binding to its own mRNA may confer autoregulation ZYRO0B00572g highly similar to uniprot|Q3E731 Saccharomyces cerevisiae YLL018C-A COX19 Cytochrome c oxidase assembly protein ZYRO0B00638g similar to uniprot|P32350 Saccharomyces cerevisiae YLL019C KNS1 Nonessential putative protein kinase of unknown cellular role member of the LAMMER family of protein kinases which are serine/threonine kinases also capable of phosphorylating tyrosine residues ZYRO0B00682g weakly similar to uniprot|Q06159 Saccharomyces cerevisiae YLR312C Hypothetical ORF ZYRO0B00704g similar to uniprot|P36523 Saccharomyces cerevisiae YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit ZYRO0B00726g weakly similar to uniprot|P23201 Saccharomyces cerevisiae YLL021W SPA2 Component of the polarisome which functions in actin cytoskeletal organization during polarized growth acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components potential Cdc28p substrate ZYRO0B00748g weakly similar to uniprot|P38995 Saccharomyces cerevisiae YDR270w CCC2 probable copper-transporting ATPase P16.2.f2.1 ZYRO0B00770g similar to uniprot|P32457 Saccharomyces cerevisiae YLR314C CDC3 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM ZYRO0B00792g weakly similar to uniprot|Q12373 Saccharomyces cerevisiae YLL022C HIF1 Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p) localized to the nucleus has a role in telomeric silencing ZYRO0B00814g similar to uniprot|Q12164 Saccharomyces cerevisiae YLL023C Hypothetical ORF ZYRO0B00836g highly similar to uniprot|P10592 Saccharomyces cerevisiae YLL024C SSA2 member of 70 kDa heat shock protein family ZYRO0B00902g similar to gnl|GLV|CAGL0E03608g Candida glabrata CAGL0E03608g and some similarites with YHL023C uniprot|P38742 Saccharomyces cerevisiae YHL023C RMD11 Protein required for sporulation ZYRO0B00924g some similarities with uniprot|P38741 Saccharomyces cerevisiae YHL024W RIM4 Putative RNA-binding protein required for the expression of early and middle sporulation genes ZYRO0B00946g highly similar to uniprot|P31539 Saccharomyces cerevisiae YLL026W HSP104 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured aggregated proteins responsive to stresses including: heat ethanol and sodium arsenite involved in [PSI ] propagation ZYRO0B00968g some similarities with uniprot|Q07821 Saccharomyces cerevisiae YLL027W ISA1 Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency depletion reduces growth on nonfermentable carbon sources ZYRO0B00990g similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Proton-motive-force-dependent multidrug transporter of the major facilitator superfamily able to transport eight different compounds including polyamines quinidine cycloheximide and nystatin involved in excess spermidine detoxification ZYRO0B01012g similar to uniprot|Q07825 Saccharomyces cerevisiae YLL029W Hypothetical ORF ZYRO0B01034g similar to uniprot|Q07830 Saccharomyces cerevisiae YLL031C ZYRO0B01056g weakly similar to uniprot|P18888 Saccharomyces cerevisiae YHL025W SNF6 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex ZYRO0B01078g similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential nuclear protein putative spliceosomal component involved in mRNA splicing based on computational analysis of large-scale protein-protein interaction data ZYRO0B01100g some similarities with uniprot|P38749 Saccharomyces cerevisiae YHL009C YAP3 bZIP transcription factor ZYRO0B01122g similar to uniprot|Q75DK5 Ashbya gossypii ABR016C ABR016Cp and weakly similar to YKL090W uniprot|P36075 Saccharomyces cerevisiae YKL090W CUE2 Protein of unknown function has two CUE domains that bind ubiquitin which may facilitate intramolecular monoubiquitination ZYRO0B01144g weakly similar to uniprot|P35201 Saccharomyces cerevisiae YKL089W MIF2 Kinetochore protein with homology to human CENP-C required for structural integrity of the spindle during anaphase spindle elongation interacts with histones H2A H2B and H4 phosphorylated by Ipl1p ZYRO0B01166g weakly similar to uniprot|Q03497 Saccharomyces cerevisiae YHL007C STE20 Signal transducing kinase of the PAK (p21-activated kinase) family involved in pheromone response and pseudohyphal/invasive growth pathways activated by Cdc42p binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases ZYRO0B01188g similar to uniprot|P33202 Saccharomyces cerevisiae YKL010C UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p two subunits of the 19S particle of the 26S proteasome cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins ZYRO0B01210g highly similar to uniprot|P33201 Saccharomyces cerevisiae YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly localizes to the nucleolus ZYRO0B01232g weakly similar to uniprot|P38751 Saccharomyces cerevisiae YHL006C SHU1 Protein involved in recombination ZYRO0B01254g similar to uniprot|P32902 Saccharomyces cerevisiae YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit ZYRO0B01276g similar to uniprot|P38703 Saccharomyces cerevisiae YHL003C LAG1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lac1p and similar to YKL008C uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lag1p ZYRO0B01298g similar to uniprot|P38753 Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation as well as for recycling of Golgi proteins and formation of lumenal membranes ZYRO0B01320g highly similar to gnl|GLV|CAGL0K02783g Candida glabrata CAGL0K02783g and similar to YKL007W uniprot|P28495 Saccharomyces cerevisiae YKL007W CAP1 Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches ZYRO0B01342g highly similar to uniprot|P43682 Saccharomyces cerevisiae YKL006C-A SFT1 Intra-Golgi v-SNARE required for transport of proteins between an early and a later Golgi compartment ZYRO0B01364g highly similar to uniprot|P36105 Saccharomyces cerevisiae YKL006W RPL14A and to uniprot|P38754 Saccharomyces cerevisiae YHL001W RPL14B Protein component of the large (60S) ribosomal subunit ZYRO0B01386g similar to uniprot|P36106 Saccharomyces cerevisiae YKL005C BYE1 Negative regulator of transcription elongation contains a TFIIS-like domain and a PHD finger multicopy suppressor of temperature-sensitive ess1 mutations probably binds RNA polymerase II large subunit ZYRO0B01408g similar to uniprot|P36107 Saccharomyces cerevisiae YKL004W AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase) required for sphingolipid synthesis can mutate to confer aureobasidin A resistance ZYRO0B01430g highly similar to uniprot|P28778 Saccharomyces cerevisiae YKL003C MRP17 Mitochondrial ribosomal protein of the small subunit MRP17 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator ZYRO0B01452g highly similar to uniprot|P36108 Saccharomyces cerevisiae YKL002W DID4 Class E Vps protein of the ESCRT-III complex required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies and for delivery of newly synthesized vacuolar enzymes to the vacuole involved in endocytosis[INTRON] ZYRO0B01474g highly similar to uniprot|Q02196 Saccharomyces cerevisiae YKL001C MET14 Adenylylsulfate kinase required for sulfate assimilation and involved in methionine metabolism ZYRO0B01496g highly similar to uniprot|P21576 Saccharomyces cerevisiae YKR001C VPS1 GTPase required for vacuolar protein sorting, functions in actin cytoskeleton organization via its interaction with Sla1p ZYRO0B01518g highly similar to uniprot|P29468 Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase one of three factors required for mRNA 3'-end polyadenylation forms multiprotein complex with polyadenylation factor I (PF I) also required for mRNA nuclear export may also polyadenylate rRNAs ZYRO0B01540g highly similar to uniprot|P38755 Saccharomyces cerevisiae YHR001W OSH7 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability ZYRO0B01562g similar to uniprot|Q02202 Saccharomyces cerevisiae YKR004C ECM9 Non-essential protein of unknown function ZYRO0B01584g some similarities with uniprot|Q02203 Saccharomyces cerevisiae YKR005C Hypothetical ORF ZYRO0B01606g similar to uniprot|Q02204 Saccharomyces cerevisiae YKR006C MRPL13 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation ZYRO0B01628g weakly similar to uniprot|Q02205 Saccharomyces cerevisiae YKR007W MEH1 ZYRO0B01650g similar to uniprot|Q02206 Saccharomyces cerevisiae YKR008W RSC4 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex found in close proximity to nucleosomal DNA displaced from the surface of nucleosomal DNA after chromatin remodeling ZYRO0B01672g similar to uniprot|P27810 Saccharomyces cerevisiae YOR099w KTR1 mannosyltransferase involved in n-linked and o-linked glycosylation ZYRO0B01694g similar to uniprot|P37299 Saccharomyces cerevisiae YHR001W-A QCR10 8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex ZYRO0B01716g similar to uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities ZYRO0B01738g similar to uniprot|P38153 Saccharomyces cerevisiae YBR288C APM3 Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway clathrin associated protein medium chain ZYRO0B01760g some similarities with uniprot|P18480 Saccharomyces cerevisiae YBR289W SNF5 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex ZYRO0B01782g similar to uniprot|P38356 Saccharomyces cerevisiae YBR290W BSD2 Heavy metal ion homeostasis protein facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded controls metal ion transport prevents metal hyperaccumulation functions in copper detoxification ZYRO0B01804g highly similar to uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter member of the mitochondrial carrier family ZYRO0B01826g highly similar to gnl|GLV|CAGL0K02915g Candida glabrata CAGL0K02915g and similar to YHR002W uniprot|P38702 Saccharomyces cerevisiae YHR002W LEU5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix homolog of human Graves disease protein does not encode an isozyme of Leu4p as first hypothesized ZYRO0B01848g highly similar to gnl|GLV|CAGL0K02937g Candida glabrata CAGL0K02937g and similar to YKL027W uniprot|P36101 Saccharomyces cerevisiae YKL027W Hypothetical ORF ZYRO0B01870g some similarities with uniprot|P36100 Saccharomyces cerevisiae YKL028W TFA1 TFIIE large subunit involved in recruitment of RNA polymerase II to the promoter activation of TFIIH and promoter opening ZYRO0B01892g conserved hypothetical protein ZYRO0B01914g highly similar to uniprot|P36013 Saccharomyces cerevisiae YKL029C MAE1 Mitochondrial malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids ZYRO0B01936g weakly similar to uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport, coiled-coil protein necessary for protein transport from ER to Golgi; Integrin analogue gene ZYRO0B01958g similar to uniprot|P38757 Saccharomyces cerevisiae YHR004C NEM1 Protein of the nuclear envelope required for the spherical shape of the nucleus required for normal sporulation ZYRO0B01980g some similarities with uniprot|Q04751 Saccharomyces cerevisiae YMR069W NAT4 N alpha-acetyl-transferase involved in acetylation of the N-terminal residues of histones H4 and H2A ZYRO0B02002g some similarities with uniprot|P54785 Saccharomyces cerevisiae YMR070W MOT3 Nuclear transcription factor with two Cys2-His2 zinc fingers involved in repression of a subset of hypoxic genes by Rox1p repression of several DAN/TIR genes during aerobic growth and repression of ergosterol biosynthetic genes ZYRO0B02024g similar to uniprot|Q04767 Saccharomyces cerevisiae YMR071C TVP18 Tlg2-Vesicle Protein of 18 kDa Integral membrane vesicle protein ZYRO0B02046g conserved hypothetical protein ZYRO0B02068g similar to uniprot|P33417 Saccharomyces cerevisiae YKL032C IXR1 Protein that binds DNA containing intrastrand cross-links formed by cisplatin contains two HMG (high mobility group box) domains which confer the ability to bend cisplatin-modified DNA mediates aerobic transcriptional repression of COX5b ZYRO0B02090g similar to gnl|GLV|KLLA0E18535g Kluyveromyces lactis KLLA0E18535g and weakly similar to YMR073C uniprot|Q04772 Saccharomyces cerevisiae YMR073C Hypothetical ORF ZYRO0B02112g conserved hypothetical protein ZYRO0B02134g similar to uniprot|Q04773 Saccharomyces cerevisiae YMR074C Hypothetical ORF ZYRO0B02156g similar to uniprot|Q04779 Saccharomyces cerevisiae YMR075W RCO1 Nuclear protein of unknown function ZYRO0B02178g similar to uniprot|Q04264 Saccharomyces cerevisiae YMR076C PDS5 Protein required for establishment and maintenance of sister chromatid condensation and cohesion colocalizes with cohesin on chromosomes in an interdependent manner may function as a protein-protein interaction scaffold ZYRO0B02200g some similarities with uniprot|P38750 Saccharomyces cerevisiae YHL008C Hypothetical ORF ZYRO0B02222g similar to uniprot|P36097 Saccharomyces cerevisiae YKL033W Protein of unknown function localized to the cytoplasm. ZYRO0B02244g similar to uniprot|P38748 YHL010C Saccharomyces cerevisiae Hypothetical ORF ZYRO0B02266g highly similar to uniprot|P38689 Saccharomyces cerevisiae YHL011C PRS3 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes ZYRO0B02288g highly similar to uniprot|Q86ZR7 YKL033W-A Saccharomyces cerevisiae YKL033W-A ZYRO0B02310g highly similar to uniprot|Q12159 Saccharomyces cerevisiae YDR381W YRA1 Nuclear protein that binds to RNA and to Mex67p ZYRO0B02332g similar to Saccharomyces uniprot|Q3E6R5 cerevisiae YDR381C-A Hypothetical ORF ZYRO0B02354g similar to uniprot|Q754C3 Ashbya gossypii AFR147C AFR147Cp ZYRO0B02376g similar to uniprot|Q12375 Saccharomyces cerevisiae YOR130C ORT1 Ornithine transporter of the mitochondrial inner membrane exports ornithine from mitochondria as part of arginine biosynthesis human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome ZYRO0B02398g highly similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm ZYRO0B02420g weakly similar to uniprot|Q12493 Saccharomyces cerevisiae YDR383C NKP1 ZYRO0B02442g similar to uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein regulation pattern suggests a possible role in export of ammonia from the cell member of the TC 9.B.33 YaaH family of putative transporters ZYRO0B02464g similar to uniprot|P32772 Saccharomyces cerevisiae YDL169C UGX2 ZYRO0B02486g similar to uniprot|P21304 Saccharomyces cerevisiae YLR196W PWP1 ZYRO0B02508g highly similar to gnl|GLV|CAGL0A04059g Candida glabrata CAGL0A04059g and similar to YLR195C uniprot|P14743 Saccharomyces cerevisiae YLR195C NMT1 N- myristoyl transferase catalyzes the cotranslational covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction ZYRO0B02530g weakly similar to uniprot|Q05777 Saccharomyces cerevisiae YLR194C ZYRO0B02552g highly similar to uniprot|Q05776 Saccharomyces cerevisiae YLR193C Hypothetical ORF ZYRO0B02574g similar to uniprot|P26370 Saccharomyces cerevisiae YDL170W UGA3 Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1 UGA2 UGA4) zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type localized to the nucleus ZYRO0B02596g highly similar to uniprot|Q12680 Saccharomyces cerevisiae YDL171C GLT1 NAD()-dependent glutamate synthase (GOGAT) synthesizes glutamate from glutamine and alpha-ketoglutarate with Gln1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source ZYRO0B02618g weakly similar to uniprot|Q6Q543 Saccharomyces cerevisiae YDL173W Hypothetical ORF ZYRO0B02640g similar to uniprot|Q05775 Saccharomyces cerevisiae YLR192C HCR1 Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA ZYRO0B02662g similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane ZYRO0B02684g no similarity ZYRO0B02706g weakly similar to uniprot|P80667 Saccharomyces cerevisiae YLR191W PEX13 Integral peroxisomal membrane receptor ZYRO0B02728g some similarities with uniprot|Q06324 Saccharomyces cerevisiae YLR190W MMR1 Phosphorylated protein of the mitochondrial outer membrane localizes only to mitochondria of the bud interacts with Myo2p to mediate mitochondrial distribution to buds mRNA is targeted to the bud via the transport system involving She2p ZYRO0B02750g no similarity ZYRO0B02772g highly similar to uniprot|P00927 Saccharomyces cerevisiae YER086W ILV1 Threonine deaminase catalyzes the first step in isoleucine biosynthesis expression is under general amino acid control ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation ZYRO0B02794g similar to uniprot|P39965 Saccharomyces cerevisiae YER087W Hypothetical ORF ZYRO0B02816g highly similar to uniprot|P52871 Saccharomyces cerevisiae YER019C-A SBH2 Ssh1p-Sss1p-Sbh2p complex component involved in protein translocation into the endoplasmic reticulum homologous to Sbh1p ZYRO0B02860g weakly similar to uniprot|P34217 Saccharomyces cerevisiae YBL051C PIN4 Protein involved in G2/M phase progression and response to DNA damage interacts with Rad53p contains an RNA recognition motif a nuclear localization signal and several SQ/TQ cluster domains hyperphosphorylated in response to DNA damage ZYRO0B02882g similar to gnl|GLV|KLLA0E20009g Kluyveromyces lactis KLLA0E20009g and weakly similar to YBL052C uniprot|P34218 Saccharomyces cerevisiae YBL052C SAS3 Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3 involved in transcriptional silencing homolog of the mammalian MOZ proto-oncogene sas3 gcn5 double mutation confers lethality ZYRO0B02904g weakly similar to uniprot|P40059 Saccharomyces cerevisiae YER088C DOT6 Protein of unknown function involved in telomeric gene silencing and filamentation ZYRO0B02926g similar to uniprot|P34220 Saccharomyces cerevisiae YBL055C Hypothetical ORF ZYRO0B02948g similar to uniprot|P34221 Saccharomyces cerevisiae YBL056W PTC3 Type 2C protein phosphatase dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p) role in DNA checkpoint inactivation ZYRO0B02970g highly similar to uniprot|P00899 Saccharomyces cerevisiae YER090W TRP2 anthranilate synthase Component I ZYRO0B02992g similar to uniprot|P34222 Saccharomyces cerevisiae YBL057C PTH2 mitochondrially-localized peptidyl-tRNA hydrolase ZYRO0B03014g similar to uniprot|P34223 Saccharomyces cerevisiae YBL058W SHP1 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate ZYRO0B03036g highly similar to uniprot|P05694 Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase involved in amino acid biosynthesis also called N5-methyltetrahydrofolate homocysteine methyltransferase or 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase ZYRO0B03058g similar to uniprot|P40060 Saccharomyces cerevisiae YER092W IES5 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions ZYRO0B03080g similar to uniprot|P40061 Saccharomyces cerevisiae YER093C TSC11 Binding Protein of TOR Protein required for cell viability ZYRO0B03102g weakly similar to uniprot|P87275 Saccharomyces cerevisiae YER093C-A Hypothetical ORF ZYRO0B03124g highly similar to uniprot|Q3E7A4 Saccharomyces cerevisiae YBL059ca ZYRO0B03146g highly similar to uniprot|P25451 Saccharomyces cerevisiae YER094C PUP3 Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit C10 ZYRO0B03168g weakly similar to uniprot|P34225 Saccharomyces cerevisiae YBL060W Hypothetical ORF ZYRO0B03190g highly similar to gnl|GLV|YALI0F15477g Yarrowia lipolytica YALI0F15477g and similar to uniprot|P25454 Saccharomyces cerevisiae YER095W RAD51 Strand exchange protein forms a helical filament with DNA that searches for homology involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis homolog of Dmc1p and bacterial RecA protein ZYRO0B03212g similar to uniprot|P34226 Saccharomyces cerevisiae YBL061C SKT5 Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation ZYRO0B03234g similar to uniprot|P28742 Saccharomyces cerevisiae YBL063W KIP1 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation functionally redundant with Cin8p ZYRO0B03256g highly similar to gnl|GLV|KLLA0E20383g Kluyveromyces lactis KLLA0E20383g and similar to YBL064C uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity has a role in reduction of hydroperoxides induced during respiratory growth and under conditions of oxidative stress ZYRO0B03278g similar to uniprot|P34228 Saccharomyces cerevisiae YBL066C SEF1 Suppressor of Essential Function putative transcription factor ZYRO0B03300g similar to uniprot|P39967 Saccharomyces cerevisiae YER098W UBP9 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions ZYRO0B03322g highly similar to uniprot|P38620 Saccharomyces cerevisiae YER099C PRS2 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes ZYRO0B03344g similar to uniprot|P33296 Saccharomyces cerevisiae YER100W UBC6 Ubiquitin-conjugating enzyme involved in ER-associated protein degradation located at the cytosolic side of the ER membrane tail region contains a transmembrane segment at the C-terminus substrate of the ubiquitin-proteasome pathway ZYRO0B03366g similar to uniprot|P35183 Saccharomyces cerevisiae YBL069W AST1 peripheral membrane protein ZYRO0B03388g highly similar to uniprot|Q3E840 Saccharomyces cerevisiae YBL071W-A KTI11 Protein required along with Dph1p Dph2p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Dph2p ZYRO0B03410g highly similar to uniprot|P05754 Saccharomyces cerevisiae YER102W RPS8B protein component of the small (40S) ribosomal subunit ZYRO0B03454g similar to uniprot|P32357 Saccharomyces cerevisiae YBL074C AAR2 Component of the U5 snRNP required for splicing of U3 precursors originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron ZYRO0B03476g highly similar to uniprot|P09435 Saccharomyces cerevisiae YBL075C SSA3 heat-inducible cytosolic member of the 70 kDa heat shock protein family ZYRO0B03498g highly similar to uniprot|P09436 Saccharomyces cerevisiae YBL076C ILS1 Cytoplasmic isoleucine-tRNA synthetase target of the G1-specific inhibitor reveromycin A ZYRO0B03520g similar to uniprot|P40063 Saccharomyces cerevisiae YER104W ZYRO0B03542g highly similar to uniprot|P38182 Saccharomyces cerevisiae YBL078C ATG8 Protein required for autophagy ZYRO0B03564g similar to uniprot|P38181 Saccharomyces cerevisiae YBL079W NUP170 Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation ZYRO0B03586g weakly similar to uniprot|P40065 Saccharomyces cerevisiae YER106W MAM1 Monopolin kinetochore associated protein involved in chromosome attachment to meiotic spindle ZYRO0B03608g similar to uniprot|P33893 Saccharomyces cerevisiae YBL080C PET112 Protein required for mitochondrial translation ZYRO0B03630g weakly similar to uniprot|P38180 Saccharomyces cerevisiae YBL081W Hypothetical ORF ZYRO0B03652g highly similar to uniprot|P40066 Saccharomyces cerevisiae YER107C GLE2 Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import homologous to S. pombe Rae1p ZYRO0B03674g some similarities with uniprot|P40068 Saccharomyces cerevisiae YER109C FLO8 Transcription factor required for flocculation diploid filamentous growth and haploid invasive growth genome reference strain S288C and most laboratory strains have a mutation in this gene ZYRO0B03696g similar to uniprot|P38179 Saccharomyces cerevisiae YBL082C RHK1 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins ZYRO0B03718g highly similar to uniprot|P40069 Saccharomyces cerevisiae YER110C KAP123 Karyopherin beta mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4 localizes to the nuclear pore nucleus and cytoplasm exhibits genetic interactions with RAI1 ZYRO0B03740g similar to uniprot|P25302 Saccharomyces cerevisiae YER111C SWI4 Involved in cell cycle dependent gene expression transcription factor ZYRO0B03762g weakly similar to uniprot|P40070 Saccharomyces cerevisiae YER112W LSM4 component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay ZYRO0B03784g similar to uniprot|P40071 Saccharomyces cerevisiae YER113C Hypothetical ORF ZYRO0B03828g similar to uniprot|P38042 Saccharomyces cerevisiae YBL084C CDC27 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition ZYRO0B03850g some similarities with uniprot|P39969 Saccharomyces cerevisiae YER114C BOI2 Protein implicated in polar growth functionally redundant with Boi1p interacts with bud-emergence protein Bem1p contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain ZYRO0B03872g conserved hypothetical protein ZYRO0B03894g similar to gnl|GLV|KLLA0E20999g Kluyveromyces lactis KLLA0E20999g and some similarites with YBL086C uniprot|P38177 Saccharomyces cerevisiae YBL086C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery ZYRO0B03916g weakly similar to uniprot|Q01684 Saccharomyces cerevisiae YER115C SPR6 sporulation-specific protein involved in sporulation ZYRO0B03938g some similarities with uniprot|P40072 Saccharomyces cerevisiae YER116C SLX8 Protein containing a RING finger domain that forms a complex with Hex3p mutant phenotypes and genetic interactions suggest a possible role in resolving recombination intermediates during DNA replication or repair ZYRO0B03960g highly similar to uniprot|P04451 Saccharomyces cerevisiae YER117W ZYRO0B03982g similar to uniprot|P38110 Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation contributes to cell cycle checkpoint control in response to DNA damage functionally redundant with Mec1p homolog of human ataxia telangiectasia (ATM) gene ZYRO0B04004g similar to uniprot|P40073 Saccharomyces cerevisiae YER118C SHO1 Transmembrane osmosensor participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway ZYRO0B04026g similar to uniprot|P40074 Saccharomyces cerevisiae YER119C AVT6 Vacuolar transporter exports aspartate and glutamate from the vacuole and to YBL089W uniprot|P38176 Saccharomyces cerevisiae YBL089W AVT5 Putative transporter, members of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ZYRO0B04048g similar to uniprot|P38175 Saccharomyces cerevisiae YBL090W MRP21 Mitochondrial ribosomal protein of the large subunit MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences ZYRO0B04070g similar to uniprot|P38174 Saccharomyces cerevisiae YBL091C MAP2 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map1p ZYRO0B04092g highly similar to uniprot|P40075 Saccharomyces cerevisiae YER120W ZYRO0B04114g highly similar to uniprot|P38061 Saccharomyces cerevisiae YBL092W RPL32 Protein component of the large (60S) ribosomal subunit has similarity to rat L32 ribosomal protein ZYRO0B04136g highly similar to uniprot|P49089 Saccharomyces cerevisiae YPR145W ASN1 Asparagine synthetase isozyme of Asn2p catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway ZYRO0B04180g similar to uniprot|Q06512 Saccharomyces cerevisiae YPR144C NOC4 Nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits ZYRO0B04224g highly similar to uniprot|P53043 Saccharomyces cerevisiae YGR123C ZYRO0B04268g similar to gnl|GLV|CAGL0D05016g Candida glabrata CAGL0D05016g and some similarites with YPR143W uniprot|Q06511 Saccharomyces cerevisiae YPR143W RRP15 Essential protein involved in pre-rRNA processing ZYRO0B04290g similar to uniprot|P17119 Saccharomyces cerevisiae YPR141C KAR3 Minus-end-directed microtubule motor that functions in mitosis and meiosis localizes to the spindle pole body and localization is dependent on functional Cik1p required for nuclear fusion during mating potential Cdc28p substrate ZYRO0B04312g similar to uniprot|Q6B2J1 Saccharomyces cerevisiae YPR140W ZYRO0B04334g similar to uniprot|Q06508 Saccharomyces cerevisiae YPR139C VPS66 ZYRO0B04356g similar to uniprot|P53272 Saccharomyces cerevisiae YGR122W Hypothetical ORF ZYRO0B04400g highly similar to uniprot|P53390 Saccharomyces cerevisiae YPR138C MEP3 Ammonium permease of high capacity and low affinity belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4) expression is under the nitrogen catabolite repression regulation ammonia permease or uniprot|P40260 Saccharomyces cerevisiae YGR121C MEP1 ZYRO0B04444g highly similar to uniprot|Q06506 Saccharomyces cerevisiae YPR137W RRP9 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Rrp9p is an ortholog of the human U3-55k protein the human cDNA partially complements a yeast rrp9 null mutant. (Pluk et al. (1998) Mol. Cell. Biol. 18 488-498.) U3 small nucleolar ribonucleoprotein-associated protein involved in pre-ribosomal RNA processing. ZYRO0B04466g similar to uniprot|Q01454 Saccharomyces cerevisiae YPR135W CTF4 Chromatin-associated protein required for sister chromatid cohesion interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion ZYRO0B04488g similar to uniprot|P53271 Saccharomyces cerevisiae YGR120C COG2 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ZYRO0B04510g some similarities with uniprot|P48837 Saccharomyces cerevisiae YGR119C NUP57 Essential subunit of the nuclear pore complex (NPC) ZYRO0B04532g weakly similar to uniprot|P08593 Saccharomyces cerevisiae YPR134W MSS18 Protein involved in splicing intron a15beta of COX1 Involved in splicing of mitochondrial COX1 transcript ZYRO0B04554g similar to uniprot|P80967 Saccharomyces cerevisiae YPR133W-A TOM5 ZYRO0B04576g some similarities with uniprot|Q06505 Saccharomyces cerevisiae YPR133C IWS1 Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II probable transcriptional elongation factor metazoan homologs contain an acidic N terminus mutations in the gene confer an Spt-phenotype ZYRO0B04598g highly similar to uniprot|P32827 Saccharomyces cerevisiae YPR132W ZYRO0B04620g no similarity ZYRO0B04642g similar to uniprot|P53270 Saccharomyces cerevisiae YGR117C Hypothetical ORF ZYRO0B04664g highly similar to gnl|GLV|CAGL0D04796g Candida glabrata CAGL0D04796g and similar to uniprot|Q06504 Saccharomyces cerevisiae YPR131C NAT3 Catalytic subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met ZYRO0B04686g some similarities with uniprot|P45978 Saccharomyces cerevisiae YPR129W SCD6 Protein containing an Lsm domain may bind RNA and have a role in RNA processing overproduction suppresses a null mutation in CHC1 which encodes the heavy chain of clathrin ZYRO0B04730g weakly similar to uniprot|Q12433 Saccharomyces cerevisiae YOR023C AHC1 Ada Histone acetyltransferase complex component protein of the Ada histone acetyltransferase complex ZYRO0B04752g similar to uniprot|Q12204 Saccharomyces cerevisiae YOR022C Hypothetical ORF ZYRO0B04774g similar to uniprot|Q12296 Saccharomyces cerevisiae YOL060C ZYRO0B04796g similar to uniprot|Q12100 Saccharomyces cerevisiae YDL025C Protein of unknown function potentially phosphorylated by Cdc28p ZYRO0B04818g similar to uniprot|Q12265 Saccharomyces cerevisiae YOL061W PRS5 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes ZYRO0B04840g highly similar to uniprot|Q99186 Saccharomyces cerevisiae YOL062C APM4 Clathrin associated protein medium subunit ZYRO0B04862g weakly similar to uniprot|Q7LHC7 Saccharomyces cerevisiae YDL027C Hypothetical ORF ZYRO0B04884g similar to uniprot|Q7LGP7 Saccharomyces cerevisiae YOL063C HUS1 Protein of unknown function ZYRO0B04906g similar to uniprot|P54199 Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function substrates include SPB proteins Spc42p Spc110p and Spc98p mitotic exit network protein Mob1p and checkpoint protein Mad1p ZYRO0B04928g highly similar to uniprot|P32381 Saccharomyces cerevisiae YDL029W ARP2 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity ZYRO0B04950g similar to uniprot|P19736 Saccharomyces cerevisiae YDL030W PRP9 Subunit of the SF3a splicing factor complex required for spliceosome assembly ZYRO0B04972g similar to uniprot|Q12389 Saccharomyces cerevisiae YDL031W DBP10 Essential protein involved in ribosome biogenesis putative ATP-dependent RNA helicase of the DEAD-box protein family ZYRO0B04994g similar to uniprot|Q12093 Saccharomyces cerevisiae YDL033C SLM3 Mitochondrial protein with a potential role in protein synthesis the bacterial homolog is responsible for the 2-thiolation of mnm5s2U34 in tRNALys tRNAGlu and tRNAGln ZYRO0B05016g similar to uniprot|P32179 Saccharomyces cerevisiae YOL064C MET22 Bisphosphate-3'-nucleotidase involved in salt tolerance and methionine biogenesis dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate intermediates of the sulfate assimilation pathway ZYRO0B05038g similar to gnl|GLV|CAGL0K01507g Candida glabrata CAGL0K01507g and some similarites with YDL035C uniprot|Q12361 Saccharomyces cerevisiae YDL035C GPR1 Plasma membrane G- protein coupled receptor that interacts with the heterotrimeric G protein alpha subunit Gpa2p and with Plc1p sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis ZYRO0B05060g similar to uniprot|Q08227 Saccharomyces cerevisiae YOL065C INP54 Phosphatidylinositol 4 5-bisphosphate 5-phosphatase with a role in secretion localizes to the endoplasmic reticulum via the C-terminal tail lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins ZYRO0B05082g similar to uniprot|Q12362 Saccharomyces cerevisiae and weakly similar to YDL036C uniprot|Q12069 Saccharomyces cerevisiae YDL036C Hypothetical ORF ZYRO0B05104g similar to uniprot|P12945 Saccharomyces cerevisiae YDL040C NAT1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing ZYRO0B05126g similar to uniprot|P32607 Saccharomyces cerevisiae YOL067C RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria peroxisomes and nucleus ZYRO0B05148g similar to uniprot|P53685 Saccharomyces cerevisiae YOL068C HST1 NAD()-dependent histone deacetylase essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing at HMR and for mitotic repression of mid-sporulation genes non-essential subunit of the Set3C deacetylase complex ZYRO0B05170g similar to uniprot|Q07350 Saccharomyces cerevisiae YDL043C PRP11 Subunit of the SF3a splicing factor complex required for spliceosome assembly ZYRO0B05192g similar to uniprot|P33895 Saccharomyces cerevisiae YOL069W NUF2 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering ZYRO0B05214g weakly similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide- bonded proteins ZYRO0B05236g similar to uniprot|Q08229 Saccharomyces cerevisiae YOL070C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud neck potential Cdc28p substrate ZYRO0B05258g weakly similar to uniprot|P10849 Saccharomyces cerevisiae YDL044C MTF2 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription ZYRO0B05280g similar to uniprot|P38913 Saccharomyces cerevisiae YDL045C FAD1 Flavin adenine dinucleotide (FAD) synthetase performs the second step in synthesis of FAD from riboflavin ZYRO0B05302g similar to uniprot|O75012 Saccharomyces cerevisiae YDL045W-A MRP10 Mitochondrial ribosomal protein of the small subunit ZYRO0B05324g highly similar to uniprot|Q08230 Saccharomyces cerevisiae YOL071W EMI5 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1 also required for sporulation ZYRO0B05346g similar to uniprot|Q12408 Saccharomyces cerevisiae YDL046W NPC2 Putative homolog of human NPC2/He1 which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes ZYRO0B05368g highly similar to uniprot|P20604 Saccharomyces cerevisiae YDL047W SIT4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization ZYRO0B05390g similar to uniprot|Q08231 Saccharomyces cerevisiae YOL072W THP1 Nuclear pore-associated protein forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus contains a PAM domain implicated in protein-protein binding ZYRO0B05412g weakly similar to uniprot|P48412 Saccharomyces cerevisiae YGR072W UPF3 Component of the nonsense-mediated mRNA decay (NMD) pathway along with Nam7p and Nmd2p involved in decay of mRNA containing nonsense codons ZYRO0B05434g conserved hypothetical protein ZYRO0B05456g highly similar to uniprot|Q02260 Saccharomyces cerevisiae YGR074W SMD1 Homolog of human core snRNP protein D1 involved in snRNA maturation U6 snRNP protein ZYRO0B05478g similar to uniprot|Q00723 Saccharomyces cerevisiae YGR075C PRP38 Unique component of the U4/U6.U5 tri-snRNP particle dispensable for spliceosome assembly but required for conformational changes which lead to catalytic activation of the spliceosome ZYRO0B05500g similar to uniprot|P23369 Saccharomyces cerevisiae YGR076C MRPL25 Mitochondrial ribosomal protein of the large subunit ZYRO0B05522g similar to uniprot|Q756P6 Ashbya gossypii AER208C AER208Cp and weakly similar to YGR077C uniprot|P53248 Saccharomyces cerevisiae YGR077C PEX8 Required for peroxisome assembly peroxisome associated protein containing a PTS1 signal ZYRO0B05544g similar to uniprot|Q08232 Saccharomyces cerevisiae YOL073C Hypothetical ORF ZYRO0B05566g highly similar to uniprot|P48363 Saccharomyces cerevisiae YGR078C PAC10 Part of the heteromeric co-chaperone GimC/prefoldin complex which promotes efficient protein folding ZYRO0B05588g similar to uniprot|Q08234 Saccharomyces cerevisiae YOL075C Hypothetical ORF ZYRO0B05610g similar to uniprot|P38276 Saccharomyces cerevisiae YBR137W Hypothetical ORF ZYRO0B05632g weakly similar to uniprot|P38277 Saccharomyces cerevisiae YBR138C Cytoplasmic protein of unknown function potentially phosphorylated by Cdc28p ZYRO0B05654g similar to uniprot|Q12387 Saccharomyces cerevisiae YOL076W MDM20 Subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met involved in mitochondrial inheritance and actin assembly ZYRO0B05676g highly similar to uniprot|Q08235 Saccharomyces cerevisiae YOL077C BRX1 Nucleolar protein involved in the biogenesis of large ribosomal subunits depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits possesses a sigma(70)-like RNA-binding motif ZYRO0B05698g similar to uniprot|P81451 Saccharomyces cerevisiae YOL077W-A ZYRO0B05720g similar to uniprot|P38109 Saccharomyces cerevisiae YBR139W ZYRO0B05742g weakly similar to uniprot|Q08236 Saccharomyces cerevisiae YOL078W AVO1 Component of a membrane-bound complex containing the Tor2p kinase and other proteins which may have a role in regulation of cell growth ZYRO0B05764g similar to uniprot|Q08237 Saccharomyces cerevisiae YOL080C REX4 Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly ZYRO0B05786g similar to uniprot|P18963 Saccharomyces cerevisiae YBR140c IRA1 or uniprot|P19158 Saccharomyces cerevisiae YOL081w IRA2 ZYRO0B05830g similar to uniprot|P38278 Saccharomyces cerevisiae YBR141C Hypothetical ORF ZYRO0B05852g similar to uniprot|P38112 Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus involved in biogenesis of large (60S) ribosomal subunits ZYRO0B05874g highly similar to uniprot|P12385 Saccharomyces cerevisiae YBR143C SUP45 Translation release factor involved in translation termination mutant form acts as a recessive omnipotent suppressor ZYRO0B05896g some similarities with uniprot|P35193 Saccharomyces cerevisiae YOL082W ATG19 Protein involved in the cytoplasm-to-vacuole targeting pathway and in autophagy, recognizes cargo proteins and delivers them to the preautophagosomal structure for eventual engulfment by the autophagosome and degradation ZYRO0B05918g similar to uniprot|Q12252 Saccharomyces cerevisiae YOL084W PHM7 Protein of unknown function expression is regulated by phosphate levels green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole ZYRO0B05940g highly similar to uniprot|P00330 Saccharomyces cerevisiae YOL086C ADH1 Alcohol dehydrogenase involved in the production of certain carboxylate esters ZYRO0B05962g highly similar to uniprot|P38120 Saccharomyces cerevisiae YBR146W MRPS9 Mitochondrial ribosomal protein of the small subunit ZYRO0B05984g similar to uniprot|Q99247 Saccharomyces cerevisiae YOL087C Hypothetical ORF ZYRO0B06006g highly similar to uniprot|P20434 Saccharomyces cerevisiae YBR154C RPB5 RNA polymerase subunit ABC27 common to RNA polymerases I II and III contacts DNA and affects transactivation ZYRO0B06028g similar to uniprot|P33312 Saccharomyces cerevisiae YBR153W RIB7 Diaminohydroxyphoshoribosylaminopyrimidine deaminase catalyzes the second step of the riboflavin biosynthesis pathway ZYRO0B06050g weakly similar to uniprot|P38282 Saccharomyces cerevisiae YBR152W ZYRO0B06072g conserved hypothetical protein ZYRO0B06094g similar to uniprot|Q99316 Saccharomyces cerevisiae YOL088C MPD2 Member of the protein disulfide isomerase (PDI) family exhibits chaperone activity overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions undergoes oxidation by Ero1p ZYRO0B06116g similar to uniprot|P38281 Saccharomyces cerevisiae YBR151W APD1 Protein of unknown function required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide localizes to both cytoplasm and nucleus ZYRO0B06138g similar to uniprot|P38115 Saccharomyces cerevisiae YBR149W ARA1 Large subunit of NADP dependent arabinose dehydrogenase involved in carbohydrate metabolism small subunit is unidentified ZYRO0B06160g highly similar to uniprot|P25847 Saccharomyces cerevisiae YOL090W MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process contains a Walker ATP-binding motif required for repair activity Msh2p-Msh6p binds to and hydrolyzes ATP ZYRO0B06182g some similarities with uniprot|Q12411 Saccharomyces cerevisiae YOL091W SPO21 Component of the meiotic outer plaque of the spindle pole body involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ZYRO0B06204g similar to uniprot|Q12010 Saccharomyces cerevisiae YOL092W Hypothetical ORF ZYRO0B06226g similar to uniprot|Q12400 Saccharomyces cerevisiae YOL093W ZYRO0B06248g highly similar to uniprot|P40339 Saccharomyces cerevisiae YOL094C RFC4 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon ZYRO0B06270g similar to uniprot|P39904 Saccharomyces cerevisiae YDR484W ZYRO0B06292g similar to uniprot|Q05379 Saccharomyces cerevisiae YOL095C HMI1 Mitochondrial inner membrane localized ATP-dependent DNA helicase required for the maintenance of the mitochondrial genome not required for mitochondrial transcription ZYRO0B06314g similar to uniprot|Q03388 Saccharomyces cerevisiae YDR485C VPS72 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting ZYRO0B06336g similar to uniprot|P27680 Saccharomyces cerevisiae YOL096C ZYRO0B06358g similar to uniprot|Q03390 Saccharomyces cerevisiae YDR486C VPS60 vacuolar protein sorting (putative) ZYRO0B06380g highly similar to uniprot|Q12109 Saccharomyces cerevisiae YOL097C WRS1 Cytoplasmic tryptophanyl-tRNA synthetase aminoacylates tryptophanyl-tRNA ZYRO0B06402g highly similar to uniprot|Q99258 Saccharomyces cerevisiae YDR487C RIB3 3 4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase) required for riboflavin biosynthesis from ribulose-5-phosphate also has an unrelated function in mitochondrial respiration ZYRO0B06424g weakly similar to uniprot|P40960 Saccharomyces cerevisiae YDR488C PAC11 Dynein intermediate chain acts in the cytoplasmic dynein pathway forms cortical cytoplasmic microtubule capture site with Num1p null mutant is defective in nuclear migration essential in the absence of CIN8 ZYRO0B06446g similar to uniprot|Q6Q558 Saccharomyces cerevisiae YDR489W SLD5 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery ZYRO0B06490g similar to uniprot|Q12496 Saccharomyces cerevisiae YOL098C Hypothetical ORF ZYRO0B06512g similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis ZYRO0B06534g no similarity ZYRO0B06556g similar to uniprot|Q6Q557 Saccharomyces cerevisiae YDR492W IZH1 Membrane protein involved in zinc metabolism member of the four-protein IZH family transcription is regulated directly by Zap1p expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc ZYRO0B06578g similar to Q03429 YDR493W uniprot|Q03429 Saccharomyces cerevisiae FMP36 ZYRO0B06600g similar to uniprot|Q12272 YOL102C Saccharomyces cerevisiae TPT1 tRNA 2'-phosphotransferase ZYRO0B06622g weakly similar to uniprot|Q8X185 Saccharomyces cerevisiae YDR494W RSM28 Mitochondrial ribosomal protein of the small subunit genetic interactions suggest a possible role in promoting translation initiation ZYRO0B06644g similar to uniprot|P23643 Saccharomyces cerevisiae YDR495C VPS3 Vacuolar sorting protein ZYRO0B06666g similar to Q04373 YDR496C uniprot|Q04373 Saccharomyces cerevisiae PUF6 Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences ZYRO0B06688g similar to uniprot|P30606 Saccharomyces cerevisiae YOL103W ITR2 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively and similar to YDR497C uniprot|P30605 Saccharomyces cerevisiae YDR497C ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p ZYRO0B06710g similar to uniprot|P28791 Saccharomyces cerevisiae YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER required for N- and O-glycosylation in the Golgi but not in the ER forms a complex with the cytosolic Tip20p ZYRO0B06732g weakly similar to uniprot|Q12366 Saccharomyces cerevisiae YOL104C NDJ1 Meiosis-specific telomere protein required for bouquet formation effective homolog pairing ordered cross-over distributio (interference) sister chromatid cohesion at meiotic telomeres and segregation of small chromosomes ZYRO0B06754g similar to uniprot|P32462 Saccharomyces cerevisiae YNL280C ERG24 C-14 sterol reductase acts in ergosterol biosynthesis mutants accumulate the abnormal sterol ignosterol (ergosta-8 14 dienol) and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions ZYRO0B06776g similar to uniprot|P53834 Saccharomyces cerevisiae YNL281W HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation GFP-fusion protein localizes to the cytoplasm and nucleus ZYRO0B06798g similar to uniprot|P53833 Saccharomyces cerevisiae YNL282W POP3 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends ZYRO0B06820g weakly similar to uniprot|P53832 Saccharomyces cerevisiae YNL283C WSC2 cell wall integrity and stress response component 2 Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1) WSC3 and WSC4 ZYRO0B06864g similar to uniprot|P36520 Saccharomyces cerevisiae YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels ZYRO0B06886g similar to uniprot|Q12239 Saccharomyces cerevisiae YOL107W Hypothetical ORF ZYRO0B06930g some similarities with uniprot|P13902 Saccharomyces cerevisiae YOL108C INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis forms a complex with Ino2p that binds the inositol-choline-responsive element through a basic helix-loop-helix domain ZYRO0B06996g weakly similar to uniprot|P53830 Saccharomyces cerevisiae YNL286W CUS2 Protein that binds to U2 snRNA and Prp11p may be involved in U2 snRNA folding contains two RNA recognition motifs (RRMs) ZYRO0B07018g highly similar to uniprot|P32074 Saccharomyces cerevisiae YNL287W SEC21 Gamma subunit of coatomer a heptameric protein complex that together with Arf1p forms the COPI coat involved in ER to Golgi transport of selective cargo ZYRO0B07040g some similarities with uniprot|P36046 Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space, involved in import and assembly of intermembrane space proteins ZYRO0B07062g similar to uniprot|P53829 Saccharomyces cerevisiae YNL288W CAF40 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation elongation and degradation binds Cdc39p ZYRO0B07084g no similarity ZYRO0B07106g similar to uniprot|Q07379 Saccharomyces cerevisiae YDL057W Hypothetical ORF ZYRO0B07128g similar to uniprot|P39678 Saccharomyces cerevisiae YDL056W MBP1 Transcription factor involved in regulation of cell cycle progression from G1 to S phase forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes ZYRO0B07150g highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure ZYRO0B07172g highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants accumulate the sterol intermediate 4 4-dimethylzymosterol ZYRO0B07216g conserved hypothetical protein ZYRO0B07238g highly similar to uniprot|P32915 Saccharomyces cerevisiae YLR378C SEC61 Essential subunit of Sec61 complex (Sec61p Sbh1p and Sss1p) forms a channel for SRP- dependent protein import and retrograde transport of misfolded proteins out of the ER with Sec63 complex allows SRP-independent protein import into ER ZYRO0B07260g similar to uniprot|Q07376 Saccharomyces cerevisiae YDL054C MCH1 ZYRO0B07282g some similarities with uniprot|Q07362 Saccharomyces cerevisiae YDL053C PBP4 Pbp1p binding protein ZYRO0B07304g highly similar to uniprot|P09201 Saccharomyces cerevisiae YLR377C FBP1 Fructose-1 6-bisphosphatase key regulatory enzyme in the gluconeogenesis pathway required for glucose metabolism ZYRO0B07326g similar to uniprot|P33333 Saccharomyces cerevisiae YDL052C SLC1 fatty acyltransferase ZYRO0B07348g similar to uniprot|Q12318 Saccharomyces cerevisiae YLR376C ZYRO0B07370g similar to uniprot|P33399 Saccharomyces cerevisiae YDL051W LHP1 RNA binding protein ZYRO0B07392g similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects ZYRO0B07414g conserved hypothetical protein ZYRO0B07436g similar to uniprot|Q7LH06 Saccharomyces cerevisiae YDL048C STP4 Protein involved in pre-tRNA splicing and in uptake of branched-chain amino acids ZYRO0B07458g similar to uniprot|P40319 Saccharomyces cerevisiae YLR372W SUR4 Elongase III synthesizes 20-26-carbon fatty acids from C18-CoA primers involved in fatty acid biosynthesis ZYRO0B07480g similar to uniprot|P51862 Saccharomyces cerevisiae YLR371W ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p mutations are synthetically lethal with mutations in rom1 which also encodes a GEP ZYRO0B07502g highly similar to uniprot|Q05933 Saccharomyces cerevisiae YLR370C ARC18 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches ZYRO0B07524g highly similar to uniprot|Q05931 Saccharomyces cerevisiae YLR369W SSQ1 Mitochondrial hsp70-type molecular chaperone involved in the synthesis and assembly of iron/sulfur clusters into proteins ZYRO0B07546g weakly similar to uniprot|Q05930 Saccharomyces cerevisiae YLR368W MDM30 Protein involved in determination of mitochondrial structure ZYRO0B07568g some similarities with uniprot|P53243 Saccharomyces cerevisiae YGR067C hypothetical ORF ZYRO0B07590g highly similar to uniprot|Q3E7Y3 Saccharomyces cerevisiae YLR367W RPS22B and highly similar to uniprot|P0C0W1 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit ZYRO0B07612g highly similar to uniprot|P53241 Saccharomyces cerevisiae YGR065C VHT1 vitamin H transporter H -biotin symporter ZYRO0B07634g similar to uniprot|Q05926 Saccharomyces cerevisiae YLR364W Hypothetical ORF ZYRO0B07656g highly similar to uniprot|P32914 Saccharomyces cerevisiae YGR063C SPT4 Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation and plays a role in pre-mRNA processing in addition Spt4p is involved in kinetochore function and gene silencing ZYRO0B07678g similar to uniprot|P53239 Saccharomyces cerevisiae YGR062C ZYRO0B07700g similar to uniprot|Q3E747 Saccharomyces cerevisiae YLR363W-A Hypothetical ORF ZYRO0B07722g highly similar to uniprot|P38972 Saccharomyces cerevisiae YGR061C ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway ZYRO0B07744g highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants accumulate the sterol intermediate 4 4-dimethylzymosterol ZYRO0B07766g similar to uniprot|Q12129 Saccharomyces cerevisiae YLR363C NMD4 Protein interacting with Nam7p may be involved in the nonsense-mediated mRNA decay pathway ZYRO0B07810g similar to uniprot|P41901 Saccharomyces cerevisiae YGR059W SPR3 a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilament genes regulated by ABFI septin protein involved in sporulation ZYRO0B07832g some similarities with uniprot|P53238 Saccharomyces cerevisiae YGR058W Hypothetical ORF ZYRO0B07854g similar to uniprot|P23561 Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p and the high osmolarity response pathway via phosphorylation of Pbs2p regulated by Ste20p and Ste50p ZYRO0B07876g weakly similar to uniprot|Q05924 Saccharomyces cerevisia YLR361C-A Identified by expression profiling and mass spectrometry ZYRO0B07898g similar to uniprot|Q05924 Saccharomyces cerevisiae YLR361C DCR2 Protein involved in cell cycle regulation ZYRO0B07920g similar to uniprot|Q6B1J7 Saccharomyces cerevisiae YLR360W VPS38 involved in vacuolar protein targeting ZYRO0B07942g similar to uniprot|P53237 Saccharomyces cerevisiae YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface ZYRO0B07964g highly similar to uniprot|Q05911 Saccharomyces cerevisiae YLR359W ADE13 Adenylosuccinate lyase catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway ZYRO0B07986g similar to uniprot|Q06488 Saccharomyces cerevisiae YLR357W RSC2 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex required for expression of mid-late sporulation-specific genes contains two essential bromodomains a bromo-adjacent homology (BAH) domain and an AT hook ZYRO0B08008g weakly similar to uniprot|P53685 Saccharomyces cerevisiae YOL068C HST1 ZYRO0B08030g similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease integral membrane protein with 13 putative membrane-spanning regions also involved in cysteine uptake ZYRO0B08052g similar to uniprot|P53235 Saccharomyces cerevisiae YGR054W yeast homolog of mammalian eIF2A ZYRO0B08074g weakly similar to uniprot|P53234 Saccharomyces cerevisiae YGR053C Hypothetical ORF ZYRO0B08096g similar to uniprot|Q45U35 Saccharomyces cerevisiae YGR049W ZYRO0B08118g highly similar to uniprot|P06168 Saccharomyces cerevisiae YLR355C ILV5 Acetohydroxyacid reductoisomerase mitochondrial protein involved in branched-chain amino acid biosynthesis also required for maintenance of wild- type mitochondrial DNA ZYRO0B08140g highly similar to uniprot|P16861 Saccharomyces cerevisiae YGR240C PFK1 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis indispensable for anaerobic growth activated by fructose-2 6-bisphosphate and AMP mutation inhibits glucose induction of cell cycle-related genes ZYRO0B08162g no similarity ZYRO0B08184g some similarities with uniprot|P50091 Saccharomyces cerevisiae YGR239C PEX21 Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2-type peroxisomal matrix proteins ZYRO0B08206g some similarities with uniprot|P38854 Saccharomyces cerevisiae YHR159W Protein of unknown function that localizes to the cytoplasm potential Cdc28p substrate ZYRO0B08228g similar to uniprot|Q75AR9 Ashbya gossypii ADL149W ADL149Wp and some similarites with YHR158C uniprot|P38853 Saccharomyces cerevisiae YHR158C KEL1 Protein required for proper cell fusion and cell morphology functions in a complex with Kel2p to negatively regulate mitotic exit interacts with Tem1p and Lte1p localizes to regions of polarized growth potential Cdc28p substrate ZYRO0B08250g no similarity ZYRO0B08272g some similarities with uniprot|P50089 Saccharomyces cerevisiae YGR237C Hypothetical ORF ZYRO0B08294g weakly similar to uniprot|P50088 Saccharomyces cerevisiae YGR236C SPG1 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources ZYRO0B08316g similar to uniprot|P81450 Saccharomyces cerevisiae YML081C-A ATP18 Subunit of the mitochondrial F1F0 ATP synthase ZYRO0B08338g similar to uniprot|P47164 Saccharomyces cerevisiae YJR130C STR2 Cystathionine gamma-synthase converts cysteine into cystathionine ZYRO0B08360g similar to uniprot|P32906 Saccharomyces cerevisiae YJR131W MNS1 Alpha-1 2-mannosidase involved in N-linked oligosaccharide biosynthesis catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc integral to the ER membrane ZYRO0B08382g similar to uniprot|P38877 Saccharomyces cerevisiae YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion ZYRO0B08404g weakly similar to uniprot|P38878 Saccharomyces cerevisiae YHR192W Hypothetical ORF ZYRO0B08426g similar to uniprot|P38879 Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation associated with cytoplasmic ribosomes ZYRO0B08448g highly similar to uniprot|P38880 Saccharomyces cerevisiae YHR194W MDM31 Mitochondrial Distribution and Morphology ZYRO0B08470g weakly similar to uniprot|P38881 Saccharomyces cerevisiae YHR195W NVJ1 Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) ZYRO0B08492g similar to uniprot|P46970 Saccharomyces cerevisiae YJR132W NMD5 Karyopherin a carrier protein involved in nuclear import of proteins importin beta homolog ZYRO0B08514g similar to uniprot|P38882 Saccharomyces cerevisiae YHR196W UTP9 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0B08536g weakly similar to uniprot|P47166 Saccharomyces cerevisiae YJR134C SGM1 Protein of unknown function required for wild-type growth rate on galactose and mannose localizes to COPI coated vesicles and the Golgi apparatus ZYRO0B08558g similar to uniprot|P38883 Saccharomyces cerevisiae YHR197W RIX1 RIbosome eXport essential protein ZYRO0B08580g similar to uniprot|P47167 Saccharomyces cerevisiae YJR135C MCM22 Protein involved in minichromosome maintenance component of the kinetochore binds to centromeric DNA in a Ctf19p-dependent manner ZYRO0B08602g highly similar to uniprot|P57744 Saccharomyces cerevisiae YJR135W-A TIM8 Mitochondrial intermembrane space import protein ZYRO0B08624g similar to uniprot|P47168 Saccharomyces cerevisiae YJR136C Hypothetical ORF ZYRO0B08646g similar to uniprot|P38884 Saccharomyces cerevisiae YHR198C FMP22 The authentic non-tagged protein was localized to the mitochondria ZYRO0B08668g highly similar to uniprot|P47169 Saccharomyces cerevisiae YJR137C ECM17 Sulfite reductase beta subunit involved in amino acid biosynthesis transcription repressed by methionine ZYRO0B08690g some similarities with uniprot|Q03661 Saccharomyces cerevisiae YMR219W ESC1 Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p ZYRO0B08712g similar to uniprot|P38886 Saccharomyces cerevisiae YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome ZYRO0B08734g similar to uniprot|P47170 Saccharomyces cerevisiae YJR138W IML1 ZYRO0B08756g highly similar to gnl|GLV|KLLA0B03872g Kluyveromyces lactis and similar to YJR139C uniprot|P31116 Saccharomyces cerevisiae HOM6 Homoserine dehydrogenase ZYRO0B08778g similar to uniprot|P47171 Saccharomyces cerevisiae YJR140C HIR3 Transcriptional corepressor ZYRO0B08800g similar to uniprot|P47172 Saccharomyces cerevisiae YJR141W Protein required for cell viability ZYRO0B08822g similar to uniprot|P38698 Saccharomyces cerevisiae YHR201C PPX1 Exopolyphosphatase hydrolyzes inorganic polyphosphate (poly P) into Pi residues located in the cytosol plasma membrane and mitochondrial matrix ZYRO0B08844g similar to uniprot|P47173 Saccharomyces cerevisiae YJR142W Hypothetical ORF ZYRO0B08866g similar to uniprot|P46971 Saccharomyces cerevisiae YJR143C PMT4 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase ZYRO0B08888g similar to uniprot|P32787 Saccharomyces cerevisiae YJR144W MGM101 Protein involved in mitochondrial genome maintenance component of the mitochondrial nucleoid required for the repair of oxidative mtDNA damage ZYRO0B08910g similar to uniprot|P43606 Saccharomyces cerevisiae YFR029W PTR3 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes ZYRO0B08932g similar to uniprot|P47051 Saccharomyces cerevisiae YJL046W Hypothetical ORF ZYRO0B08954g similar to uniprot|P38336 Saccharomyces cerevisiae YBR257W POP4 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P ZYRO0B08976g similar to uniprot|P38337 Saccharomyces cerevisiae YBR258C SHG1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres ZYRO0B08998g some similarities with uniprot|P38338 Saccharomyces cerevisiae YBR259W Hypothetical ORF ZYRO0B09020g weakly similar to uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition ZYRO0B09042g similar to uniprot|P38339 Saccharomyces cerevisiae YBR260C RGD1 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p possibly involved in control of actin cytoskeleton organization ZYRO0B09086g uniprot|Q9UVE4 Zygosaccharomyces rouxii Hypothetical protein highly similar to YBR261C uniprot|P38340 Saccharomyces cerevisiae YBR261C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family ZYRO0B09108g uniprot|Q9UVE5 Zygosaccharomyces rouxii Hypothetical protein similar to YBR262C uniprot|P38341 Saccharomyces cerevisiae YBR262C ZYRO0B09130g highly similar to gnl|GLV|KLLA0F01210g Kluyveromyces lactis KLLA0F01210g and similar to YBR263W uniprot|P37292 Saccharomyces cerevisiae YBR263W SHM1 Serine hydroxymethyltransferase mitochondrial ZYRO0B09152g similar to uniprot|P36019 Saccharomyces cerevisiae YNL093W YPT53 Involved in vacuolar protein sorting and endocytosis GTP-binding protein of the rab family ZYRO0B09174g weakly similar to uniprot|P29539 Saccharomyces cerevisiae YBR275C RIF1 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing deletion results in telomere elongation ZYRO0B09196g similar to uniprot|P38147 Saccharomyces cerevisiae YBR274W CHK1 checkpoint kinase 1 ZYRO0B09218g similar to uniprot|P38349 Saccharomyces cerevisiae YBR273C UBX7 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p ZYRO0B09240g similar to uniprot|P47048 Saccharomyces cerevisiae YJL049W Hypothetical ORF ZYRO0B09262g highly similar to uniprot|P40335 Saccharomyces cerevisiae YJL053W PEP8 Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p Vps29p Vps17p and Vps5p essential for endosome-to-Golgi retrograde protein transport ZYRO0B09284g weakly similar to uniprot|P47046 Saccharomyces cerevisiae YJL051W Protein of unknown function localized to the bud tip mRNA is targeted to the bud via the mRNA transport system involving She2p ZYRO0B09306g highly similar to uniprot|P47047 Saccharomyces cerevisiae YJL050W MTR4 Dead-box family ATP dependent helicase required for mRNA export from the nucleus co-factor of the exosome complex required for 3' end formation of 5.8S rRNA ZYRO0B09328g similar to uniprot|P38348 Saccharomyces cerevisiae YBR272C ZYRO0B09350g highly similar to uniprot|P23542 Saccharomyces cerevisiae YLR027C AAT2 Cytosolic aspartate aminotransferase involved in nitrogen metabolism localizes to peroxisomes in oleate-grown cells ZYRO0B09416g similar to uniprot|P50947 Saccharomyces cerevisiae YNL097C ZYRO0B09438g similar to uniprot|P01120 Saccharomyces cerevisiae YNL098C RAS2 GTP-binding protein that regulates the nitrogen starvation response sporulation and filamentous growth farnesylation and palmitoylation required for activity and localization to plasma membrane homolog of mammalian Ras proto-oncogenes ZYRO0B09460g similar to uniprot|P46964 Saccharomyces cerevisiae YOR103C OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins ZYRO0B09482g similar to uniprot|P50946 Saccharomyces cerevisiae YNL099C OCA1 Putative protein tyrosine phosphatase required for cell cycle arrest in response to oxidative damage of DNA ZYRO0B09504g weakly similar to uniprot|Q12057 Saccharomyces cerevisiae YOR104W PIN2 Protein that induces appearance of [PIN ] prion when overproduced ZYRO0B09526g weakly similar to uniprot|P50945 Saccharomyces cerevisiae YNL100W Hypothetical ORF ZYRO0B09548g similar to uniprot|P50944 Saccharomyces cerevisiae YNL101W AVT4 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ZYRO0B09570g no similarity ZYRO0B09592g similar to uniprot|P13382 Saccharomyces cerevisiae YNL102W POL1 Catalytic subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis ZYRO0B09614g similar to uniprot|Q12241 Saccharomyces cerevisiae YOR106W VAM3 Syntaxin-related protein required for vacuolar assembly PEP12 homolog ZYRO0B09636g some similarities with uniprot|P32389 Saccharomyces cerevisiae YNL103W MET4 Lecine-zipper transcriptional activator responsible for the regulation of the sulfur amino acid pathway requires different combinations of the auxiliary factors Cbf1p Met28p Met31p and Met32p ZYRO0B09658g some similarities with uniprot|Q99188 Saccharomyces cerevisiae YOR107W RGS2 Negative regulator of glucose-induced cAMP signaling directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p ZYRO0B09680g highly similar to uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2-isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway ZYRO0B09702g similar to uniprot|Q12271 YOR109w Saccharomyces cerevisiae INP53 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase ZYRO0B09724g highly similar to uniprot|P53930 Saccharomyces cerevisiae YNL107W YAF9 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex may function to antagonize silencing near telomeres interacts directly with Swc4p has homology to human leukemogenic protein AF9 contains a YEATS domain ZYRO0B09746g similar to uniprot|Q6B220 Saccharomyces cerevisiae YOR110W ZYRO0B09768g similar to uniprot|Q99210 Saccharomyces cerevisiae YOR111W Hypothetical ORF ZYRO0B09790g similar to uniprot|P53927 Saccharomyces cerevisiae YNL110C NOP15 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis localizes to both nucleolus and cytoplasm ZYRO0B09812g similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5 involved in the sterol and lipid biosynthesis pathways required for sterol C5-6 and fatty acid desaturation ZYRO0B09834g similar to uniprot|Q12453 Saccharomyces cerevisiae YOR112W Hypothetical ORF ZYRO0B09856g similar to uniprot|P24783 Saccharomyces cerevisiae YNL112W DBP2 Essential ATP-dependent RNA helicase of the DEAD-box protein family involved in nonsense-mediated mRNA decay and rRNA processing ZYRO0B09878g highly similar to uniprot|Q755Q7 Ashbya gossypii AFL220C AFL220Cp and similar to YNL113W uniprot|P28000 Saccharomyces cerevisiae YNL113W RPC19 RNA polymerase subunit common to RNA polymerases I and III ZYRO0B09922g similar to uniprot|P36156 Saccharomyces cerevisiae YKR076W ECM4 Non-essential protein of unknown function gnl|GLV|KLLA0F12056g Kluyveromyces lactis ZYRO0B09944g weakly similar to uniprot|P47084 Saccharomyces cerevisiae YJR003C Hypothetical ORF ZYRO0B09966g no similarity ZYRO0B09988g highly similar to uniprot|Q92280 Saccharomyces cerevisiae YLR002C NOC3 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport also binds to chromatin to promote the association of DNA replication factors and replication initiation ZYRO0B10010g similar to uniprot|P47083 Saccharomyces cerevisiae YJR002W ZYRO0B10032g similar to uniprot|P47082 Saccharomyces cerevisiae YJR001W AVT1 Vacuolar transporter imports large neutral amino acids into the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ZYRO0B10054g uniprot|Q96WU6 Zygosaccharomyces rouxii cr001 Hypothetical protein cr001-c ZYRO0B10098g highly similar to uniprot|P54861 Saccharomyces cerevisiae YLL001W DNM1 Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur also participates in endocytosis ZYRO0B10120g similar to uniprot|Q07794 Saccharomyces cerevisiae YLL002W RTT109 Regulator of Ty1 Transposition Regulation of mitochondrial network Killed in Mutagen sensitive to diepoxybutane and/or mitomycin C diepoxybutane and mitomycin C resistance ZYRO0B10142g highly similar to uniprot|P38624 YJL001W Saccharomyces cerevisiae PRE3 20S proteasome beta-type subunit ZYRO0B10164g similar to uniprot|Q12369 Saccharomyces cerevisiae YLL003W SFI1 ZYRO0B10186g similar to uniprot|P41543 Saccharomyces cerevisiae YJL002C OST1 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins ZYRO0B10208g highly similar to uniprot|P54790 Saccharomyces cerevisiae YLL004W ORC3 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing ZYRO0B10230g highly similar to gnl|GLV|KLLA0F13024g Kluyveromyces lactis KLLA0F13024g and similar to YJL003W uniprot|P47081 Saccharomyces cerevisiae YJL003W COX16 Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase ZYRO0B10252g similar to uniprot|Q07798 Saccharomyces cerevisiae YLL005C SPO75 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis ZYRO0B10274g similar to uniprot|P41800 Saccharomyces cerevisiae YLL006W MMM1 Mitochondrial outer membrane protein required for normal mitochondrial morphology and mtDNA stability involved in tethering mitochondria to the actin cytoskeleton and in anchoring mtDNA nucleoids ZYRO0B10296g similar to uniprot|Q07799 Saccharomyces cerevisiae YLL007C Hypothetical ORF ZYRO0B10318g similar to uniprot|P32892 Saccharomyces cerevisiae YLL008W DRS1 Nucleolar DEAD-box protein required for ribosome assembly and function including synthesis of 60S ribosomal subunits ZYRO0B10340g highly similar to uniprot|P41544 Saccharomyces cerevisiae YJL004C SYS1 Multicopy suppressor of ypt6 null mutation ZYRO0B10362g some similarities with uniprot|P08678 Saccharomyces cerevisiae YJL005W CYR1 Adenylate cyclase required for cAMP production and cAMP-dependent protein kinase signaling involved in cell cycle control and glucose and nitrogen repression of sporulation ZYRO0B10384g highly similar to uniprot|Q07938 Saccharomyces cerevisiae YLR017W MEU1 Methylthioadenosine phosphorylase (MTAP) catalyzes the initial step in the methionine salvage pathway affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity regulates ADH2 gene expression ZYRO0B10406g similar to uniprot|Q7LGY6 Saccharomyces cerevisiae YLR018C POM34 nuclear pore integral membrane protein ZYRO0B10428g similar to uniprot|Q07800 Saccharomyces cerevisiae YLL010C ZYRO0B10450g highly similar to uniprot|P33750 Saccharomyces cerevisiae YLL011W ZYRO0B10472g similar to uniprot|Q07950 Saccharomyces cerevisiae YLR020C YEH2 Steryl ester hydrolase catalyzes steryl ester hydrolysis at the plasma membrane involved in sterol metabolism ZYRO0B10494g similar to uniprot|Q07951 Saccharomyces cerevisiae YLR021W Hypothetical ORF ZYRO0B10516g highly similar to uniprot|Q07953 Saccharomyces cerevisiae YLR022C SDO1 Protein required for cell viability ZYRO0B10538g some similarities with uniprot|Q07959 Saccharomyces cerevisiae YLR023C IZH3 Membrane protein involved in zinc metabolism member of the four-protein IZH family expression induced by zinc deficiency deletion reduces sensitivity to elevated zinc and shortens lag phase overexpression reduces Zap1p activity ZYRO0B10560g some similarities with uniprot|Q02601 Saccharomyces cerevisiae YLL013C PUF3 member of the PUF protein family which is named for the founding members PUmilio and Fbf ZYRO0B10582g similar to uniprot|Q12431 Saccharomyces cerevisiae YLL014W Hypothetical ORF ZYRO0B10604g highly similar to uniprot|P48362 Saccharomyces cerevisiae YGR187C ZYRO0B10626g similar to uniprot|P41895 Saccharomyces cerevisiae YGR186W TFG1 Largest subunit of the RNA Polymerase general transcription factor IIF (TFIIF) interacts with Fcp1p phosphatase and with TFIIB potentially phosphorylated by Cdc28p ZYRO0B10648g highly similar to uniprot|P36421 Saccharomyces cerevisiae YGR185C TYS1 tyrosyl-tRNA synthetase cytoplasmic ZYRO0B10670g similar to uniprot|Q07963 Saccharomyces cerevisiae YLR024C UBR2 Cytoplasmic ubiquitin-protein ligase (E3) ZYRO0B10692g similar to uniprot|P19812 Saccharomyces cerevisiae YGR184C UBR1 Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway binds to the Rpn2p Rpt1p and Rpt6p proteins of the 19S particle of the 26S proteasome ZYRO0B10714g similar to uniprot|P22289 Saccharomyces cerevisiae YGR183C QCR9 7.3 kDa subunit 9 of the ubiquinol cytochrome c oxidoreductase complex ZYRO0B10736g highly similar to uniprot|P53299 Saccharomyces cerevisiae YGR181W TIM13 Translocase of the inner membrane mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins Subunit of mitochondrial protein import machinery ZYRO0B10868g highly similar to uniprot|P47064 Saccharomyces cerevisiae YJL024C APS3 Small subunit of the clathrin-associated adaptor complex AP-3 which is involved in vacuolar protein sorting related to the sigma subunit of the mammalian clathrin AP-3 complex suppressor of loss of casein kinase 1 function ZYRO0B10890g highly similar to gnl|GLV|KLLA0F15246g Kluyveromyces lactis KLLA0F15246g and similar to YGR174C uniprot|P37267 Saccharomyces cerevisiae YGR174C CBP4 Essential for the expression and activity of ubiquinol- cytochrome c reductase ubiquinol--cytochrome-c reductase assembly factor ZYRO0B10912g highly similar to uniprot|P32476 Saccharomyces cerevisiae YGR175C ERG1 Squalene epoxidase catalyzes the epoxidation of squalene to 2 3-oxidosqualene plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine ZYRO0B10934g similar to uniprot|P40992 Saccharomyces cerevisiae YJL025W RRN7 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn6p and TATA-binding protein ZYRO0B10956g similar to uniprot|P53297 Saccharomyces cerevisiae YGR178C PBP1 Protein interacting with poly(A)-binding protein Pab1p likely involved in control of the extent of mRNA polyadenylation ZYRO0B10978g weakly similar to uniprot|P53298 Saccharomyces cerevisiae YGR179C OKP1 Outer kinetochore protein required for accurate mitotic chromosome segregation forms a complex with Mcm21p and Okp1p that binds to centromeres via the CBF3 complex ZYRO0B11044g similar to uniprot|Q01477 Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments inhibitor of gene silencing cleaves ubiquitin fusions but not polyubiquitin ZYRO0B11066g similar to uniprot|P38957 Saccharomyces cerevisiae YDR078C SHU2 Suppressor of hydroxy-urea sensitivity ZYRO0B11088g similar to uniprot|P10356 Saccharomyces cerevisiae YER152C Hypothetical ORF ZYRO0B11110g similar to uniprot|O13377 Saccharomyces kluyveri PET122 Protein PET122 mitochondrial precursor and weakly similar to YER153C uniprot|P10355 Saccharomyces cerevisiae YER153C PET122 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet494p located in the mitochondrial inner membrane ZYRO0B11132g similar to uniprot|P39952 Saccharomyces cerevisiae YER154W OXA1 Translocase of the mitochondrial inner membrane mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane interacts with mitochondrial ribosomes null is respiratory deficient ZYRO0B11154g similar to uniprot|P39960 Saccharomyces cerevisiae YER155C BEM2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis required for bud emergence ZYRO0B11176g similar to uniprot|P40093 Saccharomyces cerevisiae YER156C Hypothetical ORF ZYRO0B11198g similar to uniprot|P38958 Saccharomyces cerevisiae YDR079W PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase located in the mitochondrial inner membrane ZYRO0B11220g similar to uniprot|P40094 Saccharomyces cerevisiae YER157W COG3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ZYRO0B11242g highly similar to uniprot|Q3E7C1 Saccharomyces cerevisiae YDR079C-A TFB5 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH involved in transcription initiation homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair ZYRO0B11264g similar to uniprot|P38959 Saccharomyces cerevisiae YDR080W VPS41 vacuolar protein sorting component of vacuolar membrane protein complex ZYRO0B11286g similar to uniprot|P32896 Saccharomyces cerevisiae YDR081C PDC2 Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase required for high level expression of both the THI and the PDC genes ZYRO0B11308g conserved hypothetical protein ZYRO0B11330g some similarities with uniprot|P38960 Saccharomyces cerevisiae YDR082W STN1 Protein involved in telomere length regulation functions in telomere metabolism during late S phase ZYRO0B11352g similar to uniprot|P38961 Saccharomyces cerevisiae YDR083W RRP8 ZYRO0B11374g similar to uniprot|P38962 Saccharomyces cerevisiae YDR084C TVP23 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0B11418g some similarities with uniprot|P33304 Saccharomyces cerevisiae YDR085C ZYRO0B11440g similar to uniprot|P40096 Saccharomyces cerevisiae YER159C BUR6 Protein that forms a heterodimeric histone-fold NC2 general transcription regulator complex with Ydr1p that binds to TBP and represses RNA pol II transcription during assembly of the preinitiation complex homologous to human NC2alpha ZYRO0B11462g similar to uniprot|P35179 Saccharomyces cerevisiae YDR086C SSS1 Subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) involved in transfer of secretory precursors through the endoplasmic reticulum membrane endoplasmic reticulum protein that is part of the Sec61 trimeric complex and the Ssh1 trimeric complex ZYRO0B11484g similar to uniprot|P35178 Saccharomyces cerevisiae YDR087C RRP1 involved in processing rRNA precursor species to mature rRNAs involved in rRNA processing ZYRO0B11506g similar to uniprot|Q02775 Saccharomyces cerevisiae YDR088C SLU7 Protein involved in 3' splice site choices acts in concert with Prp18p during the 2nd step of splicing ZYRO0B11550g weakly similar to uniprot|P06843 Saccharomyces cerevisiae YER161c SPT2 multifunctional HMG-like chromatin protein ZYRO0B11572g similar to uniprot|P14736 Saccharomyces cerevisiae YER162C RAD4 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair subunit of Nuclear Excision Repair Factor 2 (NEF2) homolog of human XPC protein ZYRO0B11594g similar to uniprot|P32656 Saccharomyces cerevisiae YER163C Hypothetical ORF ZYRO0B11616g highly similar to uniprot|Q03195 Saccharomyces cerevisiae YDR091C RLI1 Predicted ABC family ATPase required for translation initiation facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit may have a role in large ribosomal subunit biogenesis ZYRO0B11638g similar to uniprot|P32657 Saccharomyces cerevisiae YER164W CHD1 Sole S. cerevisiae member of CHD gene family containing Chromodomain Helicase domain and DNA-binding domain transcriptional regulator ZYRO0B11660g highly similar to uniprot|P04147 Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein part of the 3'-end RNA-processing complex mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail involved in control of poly(A) tail length interacts with translation factor eIF-4G ZYRO0B11682g highly similar to uniprot|P52490 Saccharomyces cerevisiae YDR092W UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue DNA damage triggers redistribution from the cytoplasm to the nucleus ZYRO0B11704g highly similar to uniprot|P32660 Saccharomyces cerevisiae YER166W DNF1 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the plasma membrane and late exocytic or early endocytic membranes likely involved in protein transport ZYRO0B11726g weakly similar to uniprot|P33306 Saccharomyces cerevisiae YER167W BCK2 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway which controls cell integrity overproduction suppresses pkc1 mutations ZYRO0B11748g similar to uniprot|P21269 Saccharomyces cerevisiae YER168C CCA1 tRNA nucleotidyltransferase (tRNA CCA-pyrophosphorylase) ZYRO0B11770g similar to uniprot|P39956 Saccharomyces cerevisiae YER169W RPH1 Transcriptional repressor of PHR1 which is a photolyase induced by DNA damage binds to AG(4) (C(4)T) sequence upstream of PHR1 Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway ZYRO0B11792g similar to uniprot|Q03834 Saccharomyces cerevisiae YDR097C MSH6 Protein required for mismatch repair in mitosis and meiosis forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs potentially phosphorylated by Cdc28p ZYRO0B11814g similar to uniprot|P26364 Saccharomyces cerevisiae YER170W ADK2 Mitochondrial adenylate kinase catalyzes the reversible synthesis of GTP and AMP from GDP and ADP may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions 3' sequence of ADK2 varies with strain background ZYRO0B11836g highly similar to uniprot|P06839 Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase involved in nucleotide excision repair and transcription subunit of RNA polymerase II transcription initiation factor TFIIH subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPD protein ZYRO0B11858g similar to uniprot|P32639 Saccharomyces cerevisiae YER172C BRR2 RNA-dependent ATPase RNA helicase involved in the facilitation and disruption of snRNA interactions required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis ZYRO0B11880g similar to uniprot|P32641 Saccharomyces cerevisiae YER173W RAD24 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints subunit of a clamp loader that loads Rad17p- Mec3p-Ddc1p onto DNA homolog of human and S. pombe Rad17 protein ZYRO0B11902g similar to uniprot|Q03835 Saccharomyces cerevisiae YDR098C GRX3 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase monothiol glutaredoxin subfamily member along with Grx4p and Grx5p protects cells from oxidative damage ZYRO0B11924g similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase ZYRO0B11946g similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase ZYRO0B11968g similar to uniprot|P32644 Saccharomyces cerevisiae YER176W ECM32 DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination interacts with the translation termination factors localized to polysomes ZYRO0B11990g highly similar to uniprot|Q74ZU1 Ashbya gossypii AGR107C AGR107Cp and similar to YDR099W uniprot|P34730 Saccharomyces cerevisiae YDR099W BMH2 14-3-3 protein minor isoform binds proteins and DNA involved in regulation of many processes including exocytosis and vesicle transport Ras/MAPK signaling during pseudohyphal development rapamycin- sensitive signaling and others ZYRO0B12012g similar to uniprot|Q03860 Saccharomyces cerevisiae YDR100W TVP15 Tlg2-Vesicle Protein of 15 kDa integral membrane vesicle protein ZYRO0B12034g similar to uniprot|Q03862 Saccharomyces cerevisiae YDR101C ARX1 Protein associated with the ribosomal export complex ZYRO0B12056g similar to uniprot|Q6B265 Saccharomyces cerevisiae YLR380W CSR1 Phosphatidylinositol transfer protein with a potential role in lipid turnover interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance ZYRO0B12078g similar to uniprot|Q7LHY6 Saccharomyces cerevisiae YLR381W CTF3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p may bind the kinetochore to spindle microtubules ZYRO0B12100g similar to uniprot|P11325 Saccharomyces cerevisiae YLR382C NAM2 Mitochondrial leucyl-tRNA synthetase also has a direct role in splicing of several mitochondrial group I introns indirectly required for mitochondrial genome maintenance ZYRO0B12122g similar to uniprot|Q12749 Saccharomyces cerevisiae YLR383W RHC18 Protein involved in structural maintenance of chromosomes required for interchromosomal and sister chromatid recombination ZYRO0B12144g similar to uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport coiled-coil protein necessary for protein transport from ER to Golgi Integrin analogue gene ZYRO0B12166g similar to uniprot|Q12223 Saccharomyces cerevisiae YDL059C RAD59 Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing anneals complementary single-stranded DNA homologous to Rad52p ZYRO0B12188g similar to uniprot|Q06706 Saccharomyces cerevisiae YLR384C IKI3 Subunit of RNA polymerase II elongator complex which is a histone acetyltransferase involved in maintaining structural integrity of the complex iki3 mutations confer resistance to the K. lactis toxin zymocin ZYRO0B12210g similar to uniprot|Q06707 Saccharomyces cerevisiae YLR385C SWC7 ZYRO0B12232g similar to uniprot|Q06708 Saccharomyces cerevisiae YLR386W VAC14 Activator of Fab1p ZYRO0B12254g similar to uniprot|Q7LIF0 Saccharomyces cerevisiae YLR387C REH1 Protein of unknown function, similar to Rei1p but not involved in bud growth ZYRO0B12276g similar to gnl|GLV|DEHA0A12001g Debaryomyces hansenii DEHA0A12001g and weakly similar with YDL060W uniprot|Q03128 Saccharomyces cerevisiae YDL060W TSR1 Protein required for processing of 20S pre-rRNA in the cytoplasm associates with pre-40S ribosomal particles ZYRO0B12298g highly similar to uniprot|P41058 Saccharomyces cerevisiae YDL061C or to YLR388W uniprot|P41057 Saccharomyces cerevisiae YLR388W ZYRO0B12320g similar to uniprot|Q06010 Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved with homolog Axl1p in N-terminal processing of pro-a-factor to the mature form member of the insulin-degrading enzyme family ZYRO0B12364g similar to uniprot|Q7LGT0 Saccharomyces cerevisiae YDL063C ZYRO0B12386g highly similar to uniprot|P50623 Saccharomyces cerevisiae YDL064W UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway nuclear protein required for S- and M-phase cyclin degradation and mitotic control involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) ZYRO0B12408g similar to uniprot|Q07418 Saccharomyces cerevisiae YDL065C PEX19 Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins ZYRO0B12430g some similarities with uniprot|O13547 Saccharomyces cerevisiae YLR390W-A CCW14 Secretory Stress Response protein ZYRO0B12452g similar to uniprot|P18634 Saccharomyces cerevisiae YLR392C Hypothetical ORF ZYRO0B12474g similar to uniprot|P18496 Saccharomyces cerevisiae YLR393W ATP10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase interacts genetically with ATP6 ZYRO0B12496g highly similar to uniprot|P21954 Saccharomyces cerevisiae YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase catalyzes the oxidation of isocitrate to alpha-ketoglutarate not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes ZYRO0B12518g similar to gnl|GLV|KLLA0B03333g Kluyveromyces lactis KLLA0B03333g and some similarites with YLR394W uniprot|Q06032 Saccharomyces cerevisiae YLR394W CST9 Protein required for synaptonemal complex formation may have a role in meiotic recombination localizes to synapsis initiation sites on meiotic chromosomes potential Cdc28p substrate ZYRO0B12540g similar to uniprot|P04039 Saccharomyces cerevisiae YLR395C COX8 Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain ZYRO0B12562g similar to uniprot|P07255 Saccharomyces cerevisiae YDL067C COX9 ZYRO0B12584g similar to uniprot|P20795 Saccharomyces cerevisiae YLR396C VPS33 vacuolar sorting protein essential for vacuolar morphogenesis and function involved in vacuolar protein targeting ZYRO0B12606g highly similar to uniprot|P32794 Saccharomyces cerevisiae YLR397C AFG2 ATPase of the CDC48/PAS1/SEC18 (AAA) family forms a hexameric complex may be involved in degradation of aberrant mRNAs ZYRO0B12628g weakly similar to uniprot|P14066 Saccharomyces cerevisiae YDL069C ZYRO0B12650g similar to uniprot|P35207 Saccharomyces cerevisiae YLR398C SKI2 blocks translation of non-poly(A) mRNAs antiviral protein putative helicase ZYRO0B12672g similar to uniprot|P35817 Saccharomyces cerevisiae YLR399C BDF1 Protein involved in transcription initiation at TATA-containing promoters associates with the basal transcription factor TFIID contains two bromodomains corresponds to the C-terminal region of mammalian TAF1 redundant with Bdf2p ZYRO0B12694g similar to uniprot|Q7LGS8 Saccharomyces cerevisiae YDL072C YET3 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein ZYRO0B12716g similar to uniprot|Q06053 Saccharomyces cerevisiae YLR401C DUS3 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus4p contains a consensus oleate response element (ORE) in its promoter region ZYRO0B12738g some similarities with uniprot|P32432 Saccharomyces cerevisiae YLR403W SFP1 Transcription factor that integrates information from nutrient- and stress-responsive signaling pathways to help control ribosomal protein gene expression inhibits nuclear protein localization when present in multiple copies ZYRO0B12760g similar to uniprot|Q06058 Saccharomyces cerevisiae YLR404W Hypothetical ORF ZYRO0B12782g weakly similar to uniprot|Q07454 Saccharomyces cerevisiae YDL073W Hypothetical ORF ZYRO0B12804g similar to uniprot|Q07457 Saccharomyces cerevisiae YDL074C BRE1 E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on L4 and L79) contains RING finger domain ZYRO0B12826g similar to uniprot|Q06063 Saccharomyces cerevisiae YLR405W DUS4 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus3p ZYRO0B12870g highly similar to uniprot|P04649 Saccharomyces cerevisiae YDL075W RPL31A and to YLR406C uniprot|P04649 Saccharomyces cerevisiae YLR406C RPL31B, Protein component of the large (60S) ribosomal subunit ZYRO0B12892g similar to uniprot|Q07458 Saccharomyces cerevisiae YDL076C RXT3 Hypothetical ORF ZYRO0B12914g similar to uniprot|Q06070 Saccharomyces cerevisiae YLR407W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery ZYRO0B12936g similar to uniprot|Q06071 Saccharomyces cerevisiae YLR408C Hypothetical ORF ZYRO0B12958g similar to uniprot|Q07468 Saccharomyces cerevisiae YDL077C VAM6 Protein involved in vacuolar morphogenesis ZYRO0B12980g highly similar to uniprot|Q06078 Saccharomyces cerevisiae YLR409C UTP21 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data ZYRO0B13002g highly similar to uniprot|Q06685 Saccharomyces cerevisiae YLR410W VIP1 ZYRO0B13024g highly similar to uniprot|P32895 Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of five related enzymes which are active as heteromultimeric complexes ZYRO0B13046g similar to uniprot|Q06688 Saccharomyces cerevisiae YLR412W Hypothetical ORF ZYRO0B13068g highly similar to uniprot|P07149 Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains acetyltransacylase dehydratase enoyl reductase malonyl transacylase and palmitoyl transacylase activities ZYRO0B13090g similar to uniprot|P34234 Saccharomyces cerevisiae YKL183W LOT5 Protein of unknown function gene expression increases in cultures shifted to a lower temperature ZYRO0B13112g similar to uniprot|P08432 Saccharomyces cerevisiae YKL184W SPE1 Rate limiting step of polyamine biosynthesis pathway Ornithine decarboxylase ZYRO0B13134g weakly similar to uniprot|P34233 Saccharomyces cerevisiae YKL185W ASH1 Zinc-finger inhibitor of HO transcription mRNA is localized and translated in the distal tip of anaphase cells resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression potential Cdc28p substrate ZYRO0B13156g similar to uniprot|P34232 Saccharomyces cerevisiae YKL186C MTR2 mRNA transport regulator essential nuclear protein Mex67p and Mtr2p form a mRNA export complex which binds to RNA ZYRO0B13200g similar to uniprot|Q6B322 Saccharomyces cerevisiae YLR414C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud ZYRO0B13222g no similarity ZYRO0B13266g similar to uniprot|P34230 Saccharomyces cerevisiae YKL188C PXA2 Homolog of the human adrenoleukodystrophy transporter forms a heterodimer with Pxa1p of two half ATP-binding cassette transporters in the peroxisome membrane peroxisomal ABC transporter 2 ZYRO0B13288g similar to uniprot|Q06696 Saccharomyces cerevisiae YLR417W VPS36 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome ZYRO0B13310g similar to uniprot|P32464 Saccharomyces cerevisiae YKL189W HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis interacts with Kic1p and Sog2p localizes to sites of polarized growth during budding and during the mating response ZYRO0B13332g similar to uniprot|Q06697 Saccharomyces cerevisiae YLR418C CDC73 Substituent of the Paf1 complex together with RNA polymerase II Paf1p Hpr1p Ctr9 Leo1 Rtf1 and Ccr4p distinct from Srb-containing Pol II complexes required for the expression of certain genes and modification of some histones ZYRO0B13354g similar to uniprot|Q06698 Saccharomyces cerevisiae YLR419W Hypothetical ORF ZYRO0B13376g similar to gnl|GLV|YALI0E26719g Yarrowia lipolytica YALI0E26719g uniprot|Q12724 disrupted by Saccharomyces cerevisiae Invertase 2 precursor identified start YALI0E26719g|YALI-IPF3380|YALI-CDS1951.1 and weakly similar to YIL162W uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2 ZYRO0B13398g similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression ZYRO0B13420g highly similar to uniprot|P25296 Saccharomyces cerevisiae YKL190W CNB1 Type 2B protein phosphatase ZYRO0B13442g similar to uniprot|P32461 Saccharomyces cerevisiae YKL191W DPH2 Protein required along with Dph1p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Kti11p ZYRO0B13464g highly similar to uniprot|P20051 Saccharomyces cerevisiae YLR420W URA4 Third step in pyrimidine biosynthesis pathway dihydrooratase ZYRO0B13486g similar to uniprot|O13563 Saccharomyces cerevisiae YLR421C RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid ZYRO0B13508g conserved hypothetical protein ZYRO0B13530g similar to uniprot|Q06409 Saccharomyces cerevisiae YLR422W Hypothetical ORF ZYRO0B13552g similar to uniprot|P32463 Saccharomyces cerevisiae YKL192C ACP1 Mitochondrial matrix acyl carrier protein involved in biosynthesis of octanoate which is a precursor to lipoic acid activated by phosphopantetheinylation catalyzed by Ppt2p ZYRO0B13574g similar to uniprot|P36047 Saccharomyces cerevisiae YKL193C SDS22 Regulatory subunit of Glc7p type1 protein phosphatase ZYRO0B13596g highly similar to gnl|GLV|KLLA0D02772g Kluyveromyces lactis KLLA0D02772g and similar to YKL194C uniprot|P07236 Saccharomyces cerevisiae YKL194C MST1 Mitochondrial threonyl-tRNA synthetase ZYRO0B13618g similar to uniprot|Q06410 Saccharomyces cerevisiae YLR423C ATG17 Protein that interacts with and is required for activation of Apg1p protein kinase involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway ZYRO0B13640g weakly similar to uniprot|Q06411 Saccharomyces cerevisiae YLR424W SPP382 Essential protein present in native splicing complexes identified as a suppressor of prp38-1 a spliceosomal maturation mutation cold sensitive alleles accumulate pre-mRNA ZYRO0B13662g some similarities with uniprot|P36046 Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space involved in import and assembly of intermembrane space proteins ZYRO0B13684g highly similar to uniprot|P36015 Saccharomyces cerevisiae YKL196C YKT6 v-SNARE (synaptobrevin) essential for endoplasmic reticulum-Golgi transport ZYRO0B13728g similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions ZYRO0B13750g similar to uniprot|Q06412 Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation potential Cdc28p substrate ZYRO0B13772g similar to uniprot|Q06417 Saccharomyces cerevisiae YLR426W Hypothetical ORF ZYRO0B13794g similar to uniprot|Q04969 Saccharomyces cerevisiae YML055W SPC2 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC25 ZYRO0B13816g similar to uniprot|Q06436 Saccharomyces cerevisiae YLR427W MAG2 DNA-3-methyladenine glycosidase II that catalyzes of the hydrolysis of alkylated DNA ZYRO0B13838g some similarities with uniprot|Q06440 Saccharomyces cerevisiae YLR429W CRN1 Coronin cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity ZYRO0B13860g similar to uniprot|Q00416 Saccharomyces cerevisiae YLR430W SEN1 Nuclear protein putative helicase required for processing of tRNAs rRNAs and small nuclear RNAs potential Cdc28p substrate ZYRO0B13882g similar to uniprot|Q06671 Saccharomyces cerevisiae YLR431C ATG23 Peripheral membrane protein required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway ZYRO0B13904g highly similar to uniprot|P50094 Saccharomyces cerevisiae IMD4 and to YLR432W uniprot|P50095 Saccharomyces cerevisiae IMD3 and to YHR216W uniprot|P38697 Saccharomyces cerevisiae IMD2, Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation ZYRO0B13948g similar to uniprot|P14747 Saccharomyces cerevisiae YML057W CMP2 calmodulin binding protein and to YLR433C uniprot|P23287 Saccharomyces cerevisiae YLR433C CNA1 calmodulin binding protein ZYRO0B13970g similar to uniprot|Q06672 Saccharomyces cerevisiae YLR435W TSR2 Protein with a potential role in pre-rRNA processing ZYRO0B13992g some similarities with uniprot|Q06673 Saccharomyces cerevisiae YLR436C ECM30 Non-essential protein of unknown function ZYRO0B14014g weakly similar to uniprot|O13577 Saccharomyces cerevisiae YLR437C Hypothetical ORF ZYRO0B14058g highly similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse) catalyzes the second step of arginine degradation expression is dually-regulated by allophanate induction and a specific arginine induction process not nitrogen catabolite repression sensitive ZYRO0B14080g similar to uniprot|Q04958 Saccharomyces cerevisiae YML059C NTE1 Serine esterase that deacylates exogenous lysophospholipids homolog of human neuropathy target esterase (NTE) mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine ZYRO0B14102g similar to uniprot|P57743 Saccharomyces cerevisiae YLR438C-A LSM3 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay ZYRO0B14124g similar to uniprot|P36517 Saccharomyces cerevisiae YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit ZYRO0B14146g similar to uniprot|P53397 Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7 8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA repairs oxidative damage to mitochondrial DNA ZYRO0B14168g similar to uniprot|P07271 Saccharomyces cerevisiae YML061C PIF1 DNA helicase involved in telomere formation and elongation acts as a catalytic inhibitor of telomerase also plays a role in repair and recombination of mitochondrial DNA ZYRO0B14190g similar to uniprot|Q7LHI0 Saccharomyces cerevisiae YLR440C SEC39 Protein of unknown function proposed to be involved in protein secretion ZYRO0B14212g some similarities with uniprot|P33441 Saccharomyces cerevisiae YML062C MFT1 Subunit of the THO complex which is a nuclear complex comprised of Hpr1p Mft1p Rlr1p and Thp2p that is involved in transcription elongation and mitotic recombination ZYRO0B14234g highly similar to uniprot|P23248 Saccharomyces cerevisiae RPS1B and uniprot|P33442 Saccharomyces cerevisiae YLR441C RPS1A Ribosomal protein 10 (rp10) of the small (40S) subunit ZYRO0B14256g similar to uniprot|P38987 Saccharomyces cerevisiae YML064C TEM1 Gtp-binding protein of the ras superfamily involved in termination of M-phase GTP-binding protein RAS superfamily ZYRO0B14278g similar to uniprot|P54784 Saccharomyces cerevisiae YML065W ORC1 Largest subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing may be phosphorylated by Cdc28p ZYRO0B14300g similar to uniprot|Q2VQX1 Saccharomyces cerevisiae YLR443W ECM7 Non-essential protein of unknown function ZYRO0B14322g similar to uniprot|Q04658 Saccharomyces cerevisiae YML066C SMA2 Spore Membrane Assembly ZYRO0B14344g similar to uniprot|Q04651 Saccharomyces cerevisiae YML067C ERV41 Protein in COPII-coated vesicles ZYRO0B14366g similar to uniprot|Q06201 Saccharomyces cerevisiae YLR445W ZYRO0B14388g similar to uniprot|Q04638 Saccharomyces cerevisiae YML068W ITT1 Protein that modulates the efficiency of translation termination interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro contains a zinc finger domain characteristic of the TRIAD class of proteins ZYRO0B14410g highly similar to uniprot|Q04636 Saccharomyces cerevisiae YML069W POB3 facilitates RNA Polymerase II transcription elongation ZYRO0B14432g uniprot|Q9HFC5 Zygosaccharomyces rouxii dak1 Dihydroxyacetone kinase ZYRO0B14454g some similarities with uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 BAR adaptor protein, subunit of a complex (Rvs161p-Rvs167p) that regulates actin, endocytosis, and viability following starvation or osmotic stress ZYRO0B14476g conserved hypothetical protein ZYRO0B14520g similar to uniprot|Q6B2U1 Saccharomyces cerevisiae YLR446W Hypothetical ORF ZYRO0B14542g some similarities with uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis ZYRO0B14564g highly similar to uniprot|P32366 Saccharomyces cerevisiae YLR447C VMA6 vacuolar ATPase V0 domain subunit d ZYRO0B14586g similar to uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex ZYRO0B14630g similar to uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Contains three calcium and lipid binding domains localized to the bud green fluorescent protein (GFP)-fusion protein localizes to the cell periphery mRNA is targeted to the bud via the mRNA transport system involving She2p C-terminal portion of Tcb1p Tcb2p and Tcb3p interact ZYRO0B14652g highly similar to uniprot|P05739 Saccharomyces cerevisiae YLR448W ZYRO0B14674g highly similar to uniprot|Q06205 Saccharomyces cerevisiae and to YML074c uniprot|P38911 Saccharomyces cerevisiae ZYRO0B14696g similar to uniprot|P12683 Saccharomyces cerevisiae YML075C HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate which is a rate-limiting step in sterol biosynthesis localizes to the nuclear envelope overproduction induces the formation of karmellae ZYRO0B14718g similar to uniprot|Q03631 Saccharomyces cerevisiae YML076C WAR1 zinc finger transcription factor ZYRO0B14740g highly similar to uniprot|Q03630 Saccharomyces cerevisiae YML077W BET5 Component of the TRAPP (transport protein particle) complex which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi ZYRO0B14762g similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 ABC transporter ZYRO0B14784g similar to uniprot|P47160 Saccharomyces cerevisiae YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p ZYRO0B14806g highly similar to uniprot|P25719 Saccharomyces cerevisiae YML078W CPR3 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues involved in protein refolding after import into mitochondria ZYRO0B14828g similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70 ZYRO0B14850g highly similar to uniprot|Q03629 Saccharomyces cerevisiae YML079W Uncharacterized protein with structural resemblance to plant storage and ligand binding proteins (canavalin glycinin auxin binding protein) and also to some plant and bacterial enzymes (epimerase germin) ZYRO0B14872g similar to uniprot|P53759 Saccharomyces cerevisiae YML080W DUS1 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus3p and Dus4p modifies pre-tRNA(Phe) at U17 ZYRO0B14894g similar to uniprot|Q04545 Saccharomyces cerevisiae YML081W Hypothetical ORF ZYRO0B14916g weakly similar to uniprot|P47163 Saccharomyces cerevisiae YJR129C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family ZYRO0B14960g similar to uniprot|P25335 Saccharomyces cerevisiae YIR029W DAL2 Allantoicase ZYRO0B14982g similar to uniprot|P50087 Saccharomyces cerevisiae YGR235C Hypothetical ORF ZYRO0B15004g similar to uniprot|P39676 Saccharomyces cerevisiae YGR234W YHB1 Flavohemoglobin may play a role in the oxidative stress response ZYRO0B15026g weakly similar to uniprot|P38850 Saccharomyces cerevisiae YHR154W RTT107 Regulator of Ty1 Transposition Establishes Silent Chromatin involved in silencing ZYRO0B15048g similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane ZYRO0B15070g no similarity ZYRO0B15092g similar to uniprot|P17442 Saccharomyces cerevisiae YGR233C PHO81 Cyclin-dependent kinase (CDK) inhibitor regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels required for derepression of PHO5 transcriptionally regulated by Pho4p and Pho2p ZYRO0B15114g similar to uniprot|P50086 Saccharomyces cerevisiae YGR232W NAS6 Regulatory non-ATPase subunit of the 26S proteasome homolog of the human oncoprotein gankyrin which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6 ZYRO0B15136g similar to uniprot|P50085 Saccharomyces cerevisiae YGR231C PHB2 Possible role in aging mitochondrial protein prohibitin homolog homolog of mammalian BAP37 and S. cerevisiae Phb1p ZYRO0B15158g some similarities with uniprot|P50084 Saccharomyces cerevisiae YGR230W ZYRO0B15180g similar to uniprot|P32566 Saccharomyces cerevisiae YGR229C SMI1 Protein involved in (1 3)-beta-glucan synthesis possibly through regulation of cell wall glucan and chitin synthesis chromatin binding protein 57 kDa nuclear protein ZYRO0B15202g similar to uniprot|P50076 Saccharomyces cerevisiae YGR227W DIE2 Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation has a role in regulation of ITR1 and INO1 ZYRO0B15224g similar to uniprot|P38849 Saccharomyces cerevisiae YHR151C hypothetical ORF ZYRO0B15246g similar to uniprot|P38848 Saccharomyces cerevisiae YHR150W PEX28 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p ZYRO0B15268g weakly similar to uniprot|P50082 Saccharomyces cerevisiae YGR225W AMA1 Required for sporulation highly induced during sporulation activator of meiotic anaphase promoting complex Required for sporulation highly induced during sporulation ZYRO0B15290g similar to uniprot|P50079 Saccharomyces cerevisiae YGR223C HSV2 Phosphatidylinositol 3 5-bisphosphate-binding protein predicted to fold as a seven-bladed beta-propeller displays punctate cytoplasmic localization ZYRO0B15312g similar to uniprot|P10834 Saccharomyces cerevisiae YGR222W PET54 Protein required for splicing of the COX1 intron AI5 beta also specifically required together with Pet122p and Pet494p for translation of the COX3 mRNA located in the mitochondrial inner membrane ZYRO0B15356g highly similar to uniprot|P39522 Saccharomyces cerevisiae YJR016C ILV3 Dihydroxyacid dehydratase catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids ZYRO0B15378g some similarities with uniprot|P32900 Saccharomyces cerevisiae YHR149C SKG6 Protein of unknown function found in the bud tip and bud neck potential Cdc28p substrate ZYRO0B15400g highly similar to uniprot|P32899 Saccharomyces cerevisiae YHR148W IMP3 Component of the SSU processome which is required for pre-18S rRNA processing essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA ZYRO0B15422g highly similar to uniprot|P32904 Saccharomyces cerevisiae YHR147C MRPL6 Mitochondrial ribosomal protein of the large subunit ZYRO0B15444g highly similar to uniprot|P31334 Saccharomyces cerevisiae YGR220C MRPL9 Mitochondrial ribosomal protein of the large subunit ZYRO0B15466g highly similar to uniprot|P30822 Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin involved in export of proteins RNAs and ribosomal subunits from the nucleus ZYRO0B15554g similar to uniprot|P33448 Saccharomyces cerevisiae YOR045W TOM6 involved in supporting the cooperativity between receptors and the general insertion pore and facilitating the release of preproteins from import components outer mitochondrial membrane protein component of the mitochondiral protein translocation complex associates with TOM40 ZYRO0B15576g highly similar to uniprot|P20449 Saccharomyces cerevisiae YOR046C DBP5 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus ZYRO0B15642g similar to uniprot|Q02792 Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease involved in RNA metabolism including rRNA and snRNA processing as well as mRNA transcription termination ZYRO0B15664g similar to uniprot|P36052 Saccharomyces cerevisiae YKL162C Hypothetical ORF ZYRO0B15686g similar to uniprot|Q08417 Saccharomyces cerevisiae YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane ZYRO0B15708g similar to uniprot|P36148 Saccharomyces cerevisiae YKR067W GPT2 Glycerol-3-phosphate acyltransferase located in both lipid particles and the ER involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone which are intermediate steps in lipid biosynthesis ZYRO0B15730g highly similar to uniprot|P36149 Saccharomyces cerevisiae YKR068C BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles component of the TRAPP (transport protein particle) complex ZYRO0B15752g similar to uniprot|Q6Q5I2 Saccharomyces cerevisiae YOR051C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts ZYRO0B15774g similar to uniprot|P36150 Saccharomyces cerevisiae YKR069W MET1 S-adenosyl-L-methionine uroporphyrinogen III transmethylase ZYRO0B15796g highly similar to uniprot|P36151 Saccharomyces cerevisiae YKR070W Hypothetical ORF ZYRO0B15818g some similarities with uniprot|O00017 Saccharomyces cerevisiae YOR052C ZYRO0B15840g similar to uniprot|P36152 Saccharomyces cerevisiae YKR071C DRE2 ZYRO0B15862g some similarities with uniprot|P36024 Saccharomyces cerevisiae YKR072C SIS2 Involved in cell cycle control and ion homeostasis sit4 suppressor ZYRO0B15884g similar to uniprot|O00021 Saccharomyces cerevisiae YOR056C NOB1 Nin1 (One) Binding protein essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosome subunits required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA. ZYRO0B15906g similar to uniprot|Q08446 Saccharomyces cerevisiae YOR057W SGT1 Probable cochaperone regulates activity of Cyr1p (adenylyl cyclase)involved in assembly of the kinetochore complex associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex ZYRO0B15928g similar to uniprot|P50275 Saccharomyces cerevisiae YOR058C ASE1 Member of a family of microtubule-associated proteins (MAPs) that function at the mitotic spindle midzone required for spindle elongation undergoes cell cycle-regulated degradation by anaphase promoting complex potential Cdc28p substrate ZYRO0B15972g highly similar to gnl|GLV|CAGL0G02013g Candida glabrata CAGL0G02013g and similar to YKR074W uniprot|P36154 Saccharomyces cerevisiae YKR074W Hypothetical ORF ZYRO0B15994g similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C Hypothetical ORF ZYRO0B16016g similar to uniprot|O00023 Saccharomyces cerevisiae YOR060C Protein required for cell viability ZYRO0B16038g highly similar to uniprot|P19454 Saccharomyces cerevisiae YOR061W CKA2 may have a role in regulation and/or execution of the eukaryotic cell cycle alpha' subunit of casein kinase II ZYRO0B16060g some similarities with uniprot|P36155 Saccharomyces cerevisiae or YOR062c uniprot|P36025 Saccharomyces cerevisiae ZYRO0B16082g highly similar to uniprot|P14126 Saccharomyces cerevisiae YOR063W ZYRO0B16104g weakly similar to uniprot|O00025 Saccharomyces cerevisiae YOR064C YNG1 Yeast homolog of mammalian Ing1 histone acetyltransferase complex component ZYRO0B16126g highly similar to gnl|GLV|CAGL0L10406g Candida glabrata CAGL0L10406g and similar to YOR065W uniprot|P07143 Saccharomyces cerevisiae YOR065W CYT1 Cytochrome c1 component of the mitochondrial respiratory chain expression is regulated by the heme-activated glucose- repressed Hap2p/3p/4p/5p CCAAT-binding complex ZYRO0B16148g weakly similar to uniprot|P41696 Saccharomyces cerevisiae YOR113W AZF1 Zinc-finger transcription factor involved in induction of CLN3 transcription in response to glucose genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance ZYRO0B16170g weakly similar to uniprot|Q12219 Saccharomyces cerevisiae YOR114W Hypothetical ORF ZYRO0B16192g similar to uniprot|Q99394 Saccharomyces cerevisiae YOR115C TRS33 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic ZYRO0B16214g similar to uniprot|P38822 Saccharomyces cerevisiae YHR114W BZZ1 SH3 domain protein implicated in the regulation of actin polymerization able to recruit actin polymerization machinery through its SH3 domains colocalizes with cortical actin patches and Las17p interacts with type I myosins ZYRO0B16236g similar to uniprot|P53925 Saccharomyces cerevisiae YNL115C Hypothetical ORF ZYRO0B16258g similar to uniprot|P53924 Saccharomyces cerevisiae YNL116W DMA2 Protein involved in regulating spindle position and orientation functionally redundant with Dma1p homolog of S. pombe Dma1 and H. sapiens Chfr ZYRO0B16280g highly similar to uniprot|P30952 Saccharomyces cerevisiae YNL117W MLS1 Malate synthase enzyme of the glyoxylate cycle involved in utilization of non-fermentable carbon sources expression is subject to carbon catabolite repression localizes in peroxisomes during growth in oleic acid medium ZYRO0B16302g conserved hypothetical protein ZYRO0B16324g similar to uniprot|P53550 Saccharomyces cerevisiae YNL118C DCP2 Protein required for the decapping of mRNAs functions to allow the production of active Dcp1p contains a pyrophosphatase MutT motif and several alpha-helical leucine-rich motifs ZYRO0B16346g similar to uniprot|P53923 Saccharomyces cerevisiae YNL119W NCS2 Protein with a role in urmylation and in invasive and pseudohyphal growth inhibits replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts ZYRO0B16368g similar to uniprot|Q3E833 Saccharomyces cerevisiae YKR095W-A ZYRO0B16412g similar to uniprot|P36168 Saccharomyces cerevisiae YKR096W Hypothetical ORF ZYRO0B16434g weakly similar to uniprot|P40455 Saccharomyces cerevisiae YIL152W Hypothetical ORF ZYRO0B16456g highly similar to uniprot|P10963 Saccharomyces cerevisiae YKR097W PCK1 Phosphoenolpyruvate carboxykinase key enzyme in gluconeogenesis catalyzes early reaction in carbohydrate biosynthesis glucose represses transcription and accelerates mRNA degradation regulated by Mcm1p and Cat8p located in the cytosol ZYRO0B16478g similar to uniprot|P40454 Saccharomyces cerevisiae YIL153W RRD1 Resistant to Rapamycin Deletion ZYRO0B16500g similar to uniprot|P32351 Saccharomyces cerevisiae YIL154C IMP2' Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants contains a C-terminal leucine-rich repeat ZYRO0B16522g highly similar to gnl|GLV|KLLA0A00418g Kluyveromyces lactis KLLA0A00418g and similar to YIL155C uniprot|P32191 Saccharomyces cerevisiae YIL155C GUT2 Mitochondrial glycerol-3-phosphate dehydrogenase expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p Rsf1p Hap2/3/4/5 complex dependent manner ZYRO0B16544g similar to uniprot|P40453 Saccharomyces cerevisiae YIL156W UBP7 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions ZYRO0B16566g weakly similar to uniprot|P22035 Saccharomyces cerevisiae YKR099W BAS1 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways ZYRO0B16588g highly similar to uniprot|Q2V2P4 Saccharomyces cerevisiae YIL156W-B ZYRO0B16610g similar to uniprot|P40452 Saccharomyces cerevisiae YIL157C FMP35 The authentic non-tagged protein was localized to the mitochondria ZYRO0B16632g similar to uniprot|P36169 Saccharomyces cerevisiae YKR100C SKG1 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud ZYRO0B16654g some similarities with uniprot|P40450 Saccharomyces cerevisiae YIL159W BNR1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNI1 ZYRO0B16676g highly similar to uniprot|P27796 Saccharomyces cerevisiae YIL160C POT1 3-ketoacyl-CoA thiolase with broad chain length specificity cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids ZYRO0B16698g similar to uniprot|P40449 Saccharomyces cerevisiae YIL161W Hypothetical ORF ZYRO0B16742g similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W ZYRO0B16764g similar to uniprot|P15202 Saccharomyces cerevisiae YDR256C CTA1 Catalase A breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation ZYRO0B16808g similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs ZYRO0B16852g some similarities with uniprot|Q04893 Saccharomyces cerevisiae YMR317W Hypothetical ORF ZYRO0B16896g some similarities with uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression ZYRO0B16940g similar to uniprot|Q06598 Saccharomyces cerevisiae YPR201W ARR3 Arsenite transporter of the plasma membrane required for resistance to arsenic compounds transcription is activated by Arr1p in the presence of arsenite ZYRO0B16962g some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments ZYRO0B17006g weakly similar to uniprot|P53176 Saccharomyces cerevisiae YGL051W MST27 Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles and weakly similar to YAR033W uniprot|P39552 Saccharomyces cerevisiae YAR033W MST28 Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles ZYRO0C00110g similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis ZYRO0C00132g similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase catalyzes the third step in the biotin biosynthesis pathway BIO4 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis expression appears to be repressed at low iron levels ZYRO0C00198g some similarities with uniprot|P36034 Saccharomyces cerevisiae YKL219W COS9 ZYRO0C00220g no similarity ZYRO0C00242g weakly similar to uniprot|P43542 Saccharomyces cerevisiae YFL062W COS4 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins ZYRO0C00286g no similarity ZYRO0C00308g conserved hypothetical protein ZYRO0C00330g highly similar to gnl|GLV|KLLA0C19415g Kluyveromyces lactis KLLA0C19415g and similar to uniprot|Q08579 YOR192C Saccharomyces cerevisiae Hypothetical ORF ZYRO0C00352g conserved hypothetical protein ZYRO0C00374g similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C ITR1 ZYRO0C00396g highly similar to uniprot|P07262 Saccharomyces cerevisiae and to YAL062W uniprot|P39708 Saccharomyces cerevisiae, GDH3 NADP(+)-dependent glutamate dehydrogenase, synthesize glutamate from ammonia and alpha- ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources ZYRO0C00440g similar to uniprot|P39715 Saccharomyces cerevisiae YAL059W ECM1 Protein of unknown function localized in the nucleoplasm and the nucleolus genetically interacts with MTR2 in 60S ribosomal protein subunit export ZYRO0C00462g similar to uniprot|P27825 Saccharomyces cerevisiae YAL058W CNE1 Functions in endoplasmic reticulum protein quality control Calnexin and calreticulin homolog ZYRO0C00484g highly similar to uniprot|P46367 Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase that utilizes NADP or NAD equally as coenzymes expression is glucose repressed ZYRO0C00506g weakly similar to uniprot|P32336 Saccharomyces cerevisiae YOR373W NUD1 Component of the spindle pole body outer plaque required for exit from mitosis ZYRO0C00528g weakly similar to uniprot|Q08887 Saccharomyces cerevisiae YOR372C NDD1 Transcriptional activator essential for nuclear division ZYRO0C00550g similar to uniprot|Q08886 Saccharomyces cerevisiae YOR371C GPB1 Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p has signaling role in response to nutrients involved in regulation of pseudohyphal growth through cAMP levels homolog of Gpb2p ZYRO0C00572g highly similar to uniprot|P32864 Saccharomyces cerevisiae YOR370C MRS6 Rab escort protein forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) ZYRO0C00594g highly similar to uniprot|P48589 Saccharomyces cerevisiae YOR369C ZYRO0C00616g similar to uniprot|P48581 Saccharomyces cerevisiae YOR368W RAD17 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints with Mec3p and Ddc1p forms a clamp that is loaded onto partial duplex DNA homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins ZYRO0C00638g similar to uniprot|P39718 Saccharomyces cerevisiae YAL055W ZYRO0C00660g similar to uniprot|Q08873 Saccharomyces cerevisiae YOR367W ZYRO0C00682g highly similar to uniprot|Q01574 Saccharomyces cerevisiae YAL054C ACS1 Acetyl-coA synthetase isoform expressed during growth on nonfermentable carbon sources and under aerobic conditions ZYRO0C00704g similar to uniprot|P39719 Saccharomyces cerevisiae YAL053W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0C00726g similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis ZYRO0C00748g similar to uniprot|P39721 Saccharomyces cerevisiae YAL049C Hypothetical ORF ZYRO0C00770g highly similar to uniprot|P39722 Saccharomyces cerevisiae YAL048C GEM1 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology cells lacking Gem1p contain collapsed globular or grape-like mitochondria not required for pheromone-induced cell death ZYRO0C00792g highly similar to uniprot|P21242 Saccharomyces cerevisiae YOR362C PRE10 20S proteasome alpha-type subunit ZYRO0C00814g similar to uniprot|P39723 Saccharomyces cerevisiae YAL047C SPC72 Component of the cytoplasmic Tub4p (gamma-tubulin) complex binds spindle pole bodies and links them to microtubules has roles in astral microtubule formation and stabilization ZYRO0C00836g highly similar to uniprot|P06103 Saccharomyces cerevisiae YOR361C PRT1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes ZYRO0C00858g similar to uniprot|P39724 Saccharomyces cerevisiae YAL046C Hypothetical ORF ZYRO0C00880g similar to uniprot|Q3E793 Saccharomyces cerevisiae YAL044W-A Similar to pombe uvi31 putative DNA repair protein ZYRO0C00902g similar to uniprot|P39726 Saccharomyces cerevisiae YAL044C GCV3 H subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm ZYRO0C00990g some similarities with uniprot|Q86ZS7 Saccharomyces cerevisiae YOR298C-A ZYRO0C01012g similar to uniprot|P11745 Saccharomyces cerevisiae YMR235C RNA1 GTPase activating protein (GAP) for Gsp1p involved in nuclear transport ZYRO0C01034g similar to uniprot|Q08750 Saccharomyces cerevisiae YOR298W MUM3 Protein of unknown function involved in the organization of the outer spore wall layers ZYRO0C01056g similar to uniprot|Q08749 Saccharomyces cerevisiae YOR297C TIM18 mitochondrial inner membrane translocase ZYRO0C01078g some similarities with uniprot|Q04740 Saccharomyces cerevisiae YMR234W RNH1 Ribonuclease H1 removes RNA primers during Okazaki fragment synthesis degrades RNA attached to the 5'-end of a DNA strand ZYRO0C01100g some similarities with uniprot|Q03758 Saccharomyces cerevisiae YML111W BUL2 Component of the Rsp5p E3-ubiquitin ligase complex involved in intracellular amino acid permease sorting functions in heat shock element mediated gene expression essential for growth in stress conditions functional homolog of BUL1 ZYRO0C01144g highly similar to uniprot|P40302 Saccharomyces cerevisiae YMR314W PRE5 20S proteasome alpha-type subunit ZYRO0C01166g highly similar to gnl|GLV|CAGL0M13981g Candida glabrata CAGL0M13981g and similar to uniprot|P40308 YMR313C Saccharomyces cerevisiae TGL3 Triacylglycerol lipase of the lipid particle ZYRO0C01188g similar to uniprot|Q04868 Saccharomyces cerevisiae YMR312W ELP6 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity ZYRO0C01210g highly similar to uniprot|P32527 Saccharomyces cerevisiae YGR285C ZUO1 Cytosolic ribosome-associated chaperone contains a DnaJ domain together with Ssz1p acts as a chaperone for nascent polypeptide chains ZYRO0C01232g similar to uniprot|P53337 Saccharomyces cerevisiae YGR284C ERV29 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo ZYRO0C01254g similar to uniprot|P41818 Saccharomyces cerevisiae YMR311C GLC8 Regulatory subunit of protein phosphatase 1 (Glc7p) involved in glycogen metabolism and chromosome segregation proposed to regulate Glc7p activity via conformational alteration ortholog of the mammalian protein phosphatase inhibitor 2 ZYRO0C01276g similar to uniprot|Q04867 Saccharomyces cerevisiae YMR310C Hypothetical ORF ZYRO0C01298g highly similar to gnl|GLV|CAGL0G00220g Candida glabrata CAGL0G00220g and similar to YGR282C uniprot|P15703 Saccharomyces cerevisiae YGR282C BGL2 Endo- beta-1 3-glucanase major protein of the cell wall involved in cell wall maintenance ZYRO0C01320g similar to uniprot|P32497 Saccharomyces cerevisiae YMR309C NIP1 Subunit of the eukaryotic translation initiation factor 3 (eIF3) involved in the assembly of preinitiation complex and start codon selection ZYRO0C01408g highly similar to gnl|GLV|CAGL0M13871g Candida glabrata CAGL0M13871g and similar to YMR308C uniprot|P32337 Saccharomyces cerevisiae YMR308C PSE1 Karyopherin/importin that interacts with the nuclear pore complex acts as the nuclear import receptor for specific proteins including Pdr1p Yap1p Ste12p and Aft1p ZYRO0C01430g weakly similar to uniprot|Q04602 Saccharomyces cerevisiae YDR119W Uncharacterized transporter ZYRO0C01452g similar to uniprot|P38359 Saccharomyces cerevisiae YBR294W SUL1 High affinity sulfate permease sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p which control the concentration of endogenous activated sulfate intermediates and uniprot|Q12325 Saccharomyces cerevisiae YLR092W SUL2 ZYRO0C01474g weakly similar to uniprot|Q04601 Saccharomyces cerevisiae YDR118W APC4 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition ZYRO0C01496g similar to uniprot|Q04600 Saccharomyces cerevisiae YDR117C RBF64 Hypothetical ORF ZYRO0C01518g similar to uniprot|Q04599 Saccharomyces cerevisiae YDR116C MRPL1 Mitochondrial ribosomal protein of the large subunit ZYRO0C01540g similar to uniprot|Q04598 Saccharomyces cerevisiae YDR115W ZYRO0C01562g weakly similar to uniprot|Q12393 Saccharomyces cerevisiae YLR091W Hypothetical ORF ZYRO0C01584g weakly similar to uniprot|P40316 Saccharomyces cerevisiae YDR113C PDS1 Securin that inhibits anaphase by binding separin Esp1p also blocks cyclin destruction and mitotic exit essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles also present in meiotic nuclei ZYRO0C01606g similar to uniprot|P39102 Saccharomyces cerevisiae YLR090W XDJ1 Putative homolog of E. coli DnaJ closely related to Ydj1p ZYRO0C01628g similar to uniprot|P52893 Saccharomyces cerevisiae YLR089C ALT1 putative alanine transaminase (glutamyc pyruvic transaminase) ZYRO0C01650g some similarities with uniprot|O13329 Saccharomyces cerevisiae YDR110W FOB1 Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities binds to the replication fork barrier site in the rDNA region related to retroviral integrases ZYRO0C01672g similar to uniprot|P39012 Saccharomyces cerevisiae YLR088W GAA1 Subunit of the GPI:protein transamidase complex removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER ZYRO0C01694g similar to uniprot|Q12150 Saccharomyces cerevisiae YLR087C CSF1 Protein required for fermentation at low temperature ZYRO0C01716g similar to uniprot|Q12267 Saccharomyces cerevisiae YLR086W SMC4 Subunit of the condensin complex which reorganizes chromosomes during cell division forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity and promotes knotting of circular DNA potential Cdc28p substrate ZYRO0C01738g similar to uniprot|Q12509 Saccharomyces cerevisiae YLR085C ARP6 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes ZYRO0C01782g similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Hypothetical ORF ZYRO0C01804g similar to uniprot|Q12465 Saccharomyces cerevisiae YLR084C RAX2 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding localization requires Rax1p ZYRO0C01826g similar to uniprot|P46944 Saccharomyces cerevisiae YDR108W GSG1 Subunit of TRAPP (transport protein particle) a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment protein has late meiotic role following DNA replication ZYRO0C01848g similar to uniprot|P32802 Saccharomyces cerevisiae YLR083C EMP70 Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions predicted to be a transmembrane protein ZYRO0C01892g some similarities with uniprot|Q3E784 Saccharomyces cerevisiae YER180C-A SLO1 SCOCO like ORF ZYRO0C01914g similar to uniprot|P32645 Saccharomyces cerevisiae YER180C ISC10 Protein required for sporulation transcript is induced 7.5 hours after induction of meiosis expected to play significant role in the formation of reproductive cells ZYRO0C01936g similar to uniprot|Q12116 Saccharomyces cerevisiae YDR105C TMS1 Putative membrane protein conserved in mammals ZYRO0C01958g highly similar to uniprot|P25453 Saccharomyces cerevisiae YER179W DMC1 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes homolog of Rad51p and the bacterial RecA protein ZYRO0C01980g similar to uniprot|Q03868 Saccharomyces cerevisiae YDR104C SPO71 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis ZYRO0C02002g similar to uniprot|P32917 Saccharomyces cerevisiae YDR103W STE5 Scaffold protein that in response to pheromone shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p Ste7p and Fus3p into a specific signaling complex active oligomeric form interacts with Ste4p-Ste18p complex ZYRO0C02024g highly similar to gnl|GLV|CAGL0L12078g Candida glabrata CAGL0L12078g and similar to YER178W uniprot|P16387 Saccharomyces cerevisiae YER178W PDA1 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA regulated by glucose ZYRO0C02068g similar to uniprot|P24867 Saccharomyces cerevisiae YNL289W PCL1 Pho85 cyclin of the Pcl1 2-like subfamily involved in entry into the mitotic cell cycle and regulation of morphogenesis localizes to sites of polarized cell growth ZYRO0C02090g highly similar to uniprot|P38629 Saccharomyces cerevisiae YNL290W RFC3 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon ZYRO0C02112g similar to uniprot|P41821 Saccharomyces cerevisiae YNL291C MID1 N-glycosylated integral plasma membrane protein ZYRO0C02134g similar to uniprot|P48567 Saccharomyces cerevisiae YNL292W PUS4 catalyzes formation of Psi55 (modified uridine) in mitochondrial and cytoplasmic tRNAs Pseudouridine synthase ZYRO0C02156g similar to uniprot|P41912 Saccharomyces cerevisiae YOL110W SHR5 Subunit of a palmitoyltransferase composed of Shr5p and Erf2p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage palmitoylation is required for Ras2p localization to the plasma membrane ZYRO0C02178g similar to uniprot|Q12285 Saccharomyces cerevisiae YOL111C Hypothetical ORF ZYRO0C02200g similar to uniprot|P48566 Saccharomyces cerevisiae YNL293W ZYRO0C02222g similar to uniprot|P48565 Saccharomyces cerevisiae YNL294C RIM21 Protein proposed to be involved in the response to alkaline pH; has similarity to A. nidulans PalH ZYRO0C02244g similar to gnl|GLV|KLLA0A07447g Kluyveromyces lactis KLLA0A07447g and weakly similar to YNL295W uniprot|P48564 Saccharomyces cerevisiae YNL295W Hypothetical ORF ZYRO0C02266g similar to uniprot|P48563 Saccharomyces cerevisiae YNL297C MON2 Peripheral membrane protein with a role in endocytosis and vacuole integrity interacts with Arl1p and localizes to the endosome member of the Sec7p family of proteins ZYRO0C02288g some similarities with uniprot|P48562 Saccharomyces cerevisiae YNL298W CLA4 Involved in localizing cell growth with respect to the septin ring protein kinase homologous to Ste20p interacts with CDC42 ZYRO0C02310g similar to uniprot|Q12322 Saccharomyces cerevisiae YOL114C Hypothetical ORF ZYRO0C02332g similar to uniprot|P53632 Saccharomyces cerevisiae YOL115W TRF4 DNA polymerase sigma involved in mitotic chromsome condensation ZYRO0C02354g highly similar to uniprot|P07170 Saccharomyces cerevisiae YDR226W ADK1 adenylate kinase ZYRO0C02376g some similarities with uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression invasive growth and pseudohyphal differentiation iron uptake chromium accumulation and response to osmotic stress localizes to the nucleus ZYRO0C02398g some similarities with uniprot|P48560 Saccharomyces cerevisiae YNL300W ZYRO0C02420g weakly similar to uniprot|Q12348 Saccharomyces cerevisiae YOL117W RRI2 subunit of COP9 Signalosome (CSN) like protein complex that cleaves the ubiquitin-like protein Rub1 from Cdc53 COP9 signalosome (CSN) subunit ZYRO0C02442g similar to uniprot|P38013 Saccharomyces cerevisiae YLR109W AHP1 Thiol-specific peroxiredoxin ZYRO0C02464g similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport ZYRO0C02486g similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport ZYRO0C02508g highly similar to uniprot|P07279 Saccharomyces cerevisiae YOL120C RPL18A Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation ZYRO0C02530g highly similar to uniprot|P07280 Saccharomyces cerevisiae YOL121C RPS19A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps19Bp and has similarity to rat S19 ribosomal protein ZYRO0C02552g similar to uniprot|P38925 Saccharomyces cerevisiae YOL122C SMF1 Divalent metal ion transporter ZYRO0C02574g weakly similar to uniprot|Q99383 Saccharomyces cerevisiae YOL123W HRP1 Subunit of cleavage factor I a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences ZYRO0C02596g highly similar to uniprot|Q12463 Saccharomyces cerevisiae YOL124C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family ZYRO0C02618g similar to uniprot|P48559 Saccharomyces cerevisiae YNL304W YPT11 Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells ZYRO0C02640g similar to uniprot|Q12383 Saccharomyces cerevisiae YOL125W Hypothetical ORF ZYRO0C02684g similar to uniprot|P22133 Saccharomyces cerevisiae YOL126C MDH2 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in gluconeogenesis and glyoxylate cycle ZYRO0C02706g similar to uniprot|P48558 Saccharomyces cerevisiae YNL305C Hypothetical ORF ZYRO0C02728g highly similar to gnl|GLV|KLLA0E07458g Kluyveromyces lactis KLLA0E07458g and similar to YOL127W uniprot|P04456 Saccharomyces cerevisiae Primary rRNA- binding ribosomal protein component of the large (60S) ribosomal subunit ZYRO0C02750g similar to uniprot|P42847 Saccharomyces cerevisiae YNL306W MRPS18 Mitochondrial ribosomal protein of the small subunit essential for viability unlike most other mitoribosomal proteins ZYRO0C02772g highly similar to uniprot|P21965 Saccharomyces cerevisiae YNL307C MCK1 Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis related to mammalian glycogen synthase kinases of the GSK-3 family ZYRO0C02794g similar to uniprot|Q12016 Saccharomyces cerevisiae YOL129W VPS68 ZYRO0C02816g similar to uniprot|P42846 Saccharomyces cerevisiae YNL308C KRI1 Essential nucleolar protein required for 40S ribosome biogenesis physically and functionally interacts with Krr1p ZYRO0C02838g similar to uniprot|Q08269 Saccharomyces cerevisiae YOL130W ALR1 Plasma membrane Mg(2+) transporter expression and turnover are regulated by Mg(2+) concentration overexpression confers increased tolerance to Al(3+) and Ga(3+) ions and similar to YFL050C uniprot|P43553 Saccharomyces cerevisiae YFL050C ALR2 Probable Mg(2+)transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions ZYRO0C02860g some similarities with uniprot|P42845 Saccharomyces cerevisiae YNL309W ZYRO0C02882g similar to uniprot|Q75AU3 Ashbya gossypii ADL173C ADL173Cp and weakly similar to YNL310C uniprot|P42844 Saccharomyces cerevisiae YNL310C ZIM17 Essential component of the mitochondrial import system zinc finger protein that may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix ZYRO0C02904g similar to uniprot|P42843 Saccharomyces cerevisiae YNL311C F-box protein ZYRO0C02926g similar to uniprot|Q08271 Saccharomyces cerevisiae YOL132W GAS4 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall ZYRO0C02948g similar to uniprot|P26754 Saccharomyces cerevisiae YNL312W RFA2 Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination ZYRO0C02970g similar to uniprot|P42842 Saccharomyces cerevisiae YNL313C Protein required for cell viability ZYRO0C02992g some similarities with uniprot|P21705 Saccharomyces cerevisiae YNL314W DAL82 Positive regulator of allophanate inducible genes binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate contains an UISALL DNA-binding a transcriptional activation and a coiled-coil domain ZYRO0C03014g similar to uniprot|P32453 Saccharomyces cerevisiae YNL315C ATP11 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase ZYRO0C03036g similar to uniprot|P32452 Saccharomyces cerevisiae YNL316C PHA2 Prephenate dehydratase catalyzes the conversion of prephanate to phenylpyruvate which is a step in the phenylalanine biosynthesis pathway ZYRO0C03058g highly similar to uniprot|Q08273 Saccharomyces cerevisiae YOL133W HRT1 RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF) required for Gic2p Far1p Sic1p and Cln2p degradation may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF ZYRO0C03080g similar to uniprot|Q08278 Saccharomyces cerevisiae YOL135C ZYRO0C03102g weakly similar to uniprot|Q12471 Saccharomyces cerevisiae YOL136C PFK27 6-phosphofructo-2-kinase has negligible fructose-2 6-bisphosphatase activity inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate expression induced by glucose and sucrose transcriptional regulation involves protein kinase A ZYRO0C03124g highly similar to uniprot|Q75AV4 Ashbya gossypii ADL184W PSF2 Polyadenylation factor subunit 2 and similar to YNL317W uniprot|P42841 Saccharomyces cerevisiae YNL317W PFS2 Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex ZYRO0C03146g similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W BSC6 Protein of unknown function containing 8 putative transmembrane seqments ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression ZYRO0C03168g similar to uniprot|P42833 Saccharomyces cerevisiae YNL318C ZYRO0C03190g similar to uniprot|Q92271 Saccharomyces cerevisiae YOL138C Hypothetical ORF ZYRO0C03212g highly similar to uniprot|P42840 Saccharomyces cerevisiae YNL320W Hypothetical ORF ZYRO0C03234g highly similar to uniprot|P07260 Saccharomyces cerevisiae YOL139C CDC33 Cytoplasmic mRNA cap binding protein the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p) ZYRO0C03256g similar to uniprot|P42839 Saccharomyces cerevisiae YNL321W Protein of unknown function potential Cdc28p substrate ZYRO0C03278g weakly similar to uniprot|P17260 Saccharomyces cerevisiae YNL322C KRE1 Cell wall glycoprotein involved in beta-glucan assembly serves as a K1 killer toxin membrane receptor ZYRO0C03300g highly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine ZYRO0C03322g similar to uniprot|P42838 YNL323W Saccharomyces cerevisiae YNL323W LEM3 Membrane protein of the plasma membrane and ER ZYRO0C03344g similar to similar to uniprot|Q08282 YOL141w Saccharomyces cerevisiae PPM2 Putative carboxyl methyl transferase ZYRO0C03366g similar to uniprot|P42837 Saccharomyces cerevisiae YNL325C FIG4 Protein required for efficient mating member of a family of eukaryotic proteins that contain a domain homologous to Sac1p ZYRO0C03388g similar to uniprot|Q08285 Saccharomyces cerevisiae YOL142W RRP40 Ribosomal RNA Processing Rrp40p ZYRO0C03410g similar to uniprot|P42836 Saccharomyces cerevisiae YNL326C PFA3 Palmitoyltransferase for Vac8p one of three yeast DHHC-cysteine rich domain proteins (Pfa3p Erf2p Akr1p) with palmitoyltransferase activity required for vacuolar integrity under stress conditions ZYRO0C03432g some similarities with uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner ZYRO0C03454g similar to uniprot|P42834 Saccharomyces cerevisiae YNL328C MDJ2 Protein of the mitochondrial inner membrane function partially overlaps that of Mdj1p which is a chaperone involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix member of the DnaJ family ZYRO0C03476g similar to uniprot|P33760 Saccharomyces cerevisiae YNL329C PEX6 Required for peroxisome assembly Member of the AAA-protein family that includes NSFp and PEX1p ZYRO0C03498g highly similar to uniprot|P32561 Saccharomyces cerevisiae YNL330C RPD3 Histone deacetylase regulates transcription and silencing ZYRO0C03520g highly similar to uniprot|P50861 Saccharomyces cerevisiae YOL143C RIB4 Lumazine synthase (6 7-dimethyl-8-ribityllumazine synthase also known as DMRL synthase) catalyzes synthesis of immediate precursor to riboflavin ZYRO0C03542g similar to uniprot|Q08287 Saccharomyces cerevisiae YOL144W NOP8 Nucleolar protein required for 60S ribosomal subunit biogenesis ZYRO0C03564g similar to uniprot|P89105 Saccharomyces cerevisiae YOL145C CTR9 Component of the Paf1p complex which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes including cyclin genes contains TPR repeats ZYRO0C03586g similar to uniprot|Q12146 Saccharomyces cerevisiae YOL146W PSF3 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery ZYRO0C03608g similar to uniprot|Q12462 Saccharomyces cerevisiae YOL147C PEX11 Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation most abundant protein in the peroxisomal membrane regulated by Adr1p and Pip2p-Oaf1p promoter contains ORE and UAS1-like elements ZYRO0C03630g similar to uniprot|P50875 Saccharomyces cerevisiae YOL148C SPT20 Subunit of the SAGA transcriptional regulatory complex involved in maintaining the integrity of the complex ZYRO0C03652g highly similar to uniprot|Q74Z05 Ashbya gossypii AGR402C DCP1 mRNA decapping enzyme subunit 1 and similar to uniprot|Q12517 Saccharomyces cerevisiae YOL149W DCP1 Decapping enzyme essential phosphoprotein component of mRNA decapping complex plays key role in mRNA decay by cleaving off the 5' cap to leave the end susceptible to exonucleolytic degradation regulated by DEAD box protein Dhh1p ZYRO0C03674g highly similar to uniprot|Q04869 Saccharomyces cerevisiae YMR315W Hypothetical ORF ZYRO0C03696g highly similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF ZYRO0C03718g similar to uniprot|Q03973 Saccharomyces cerevisiae YDR174W HMO1 Chromatin associated high mobility group (HMG) family member involved in genome maintenance rDNA- binding component of the Pol I transcription system associates with a 5'-3' DNA helicase and Fpr1p a prolyl isomerase ZYRO0C03740g similar to uniprot|Q03976 Saccharomyces cerevisiae YDR175C RSM24 Mitochondrial ribosomal protein of the small subunit ZYRO0C03762g similar to uniprot|P32494 Saccharomyces cerevisiae YDR176W NGG1 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes component of transcriptional adaptor and histone acetyltransferase complexes the ADA complex the SAGA complex and the SLIK complex ZYRO0C03784g highly similar to uniprot|P21734 Saccharomyces cerevisiae YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD) component of the cellular stress response ZYRO0C03806g highly similar to uniprot|P10507 Saccharomyces cerevisiae YLR163C MAS1 Smaller subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins ZYRO0C03828g similar to uniprot|P37298 Saccharomyces cerevisiae YDR178W SDH4 Membrane anchor subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone ZYRO0C03850g similar to uniprot|Q03981 Saccharomyces cerevisiae YDR179C CSN9 Subunit of the Cop9 signalosome which is required for deneddylation or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin) involved in adaptation to pheromone signaling ZYRO0C03872g some similarities with uniprot|Q03984 Saccharomyces cerevisiae YDR179W-A Hypothetical ORF ZYRO0C03894g similar to uniprot|Q06244 Saccharomyces cerevisiae YLR165C PUS5 ZYRO0C03916g similar to uniprot|Q04002 Saccharomyces cerevisiae YDR180W SCC2 Sister chromatid cohesion protein ZYRO0C03938g weakly similar to uniprot|Q04003 Saccharomyces cerevisiae YDR181c SAS4 ZYRO0C03960g similar to uniprot|P40986 Saccharomyces cerevisiae YDR182W CDC1 Putative membrane protein of unknown function involved in Mn2 homeostasis mutants display actin and general growth defects heterogeneous cell cycle arrests and pleiotropic defects in cell cycle progression and organelle distribution ZYRO0C03982g similar to uniprot|Q06245 Saccharomyces cerevisiae YLR166C SEC10 Essential 100kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis ZYRO0C04004g similar to uniprot|Q04004 Saccharomyces cerevisiae YDR183W ZYRO0C04026g similar to uniprot|P05759 Saccharomyces cerevisiae YLR167W RPS31 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin ubiquitin may facilitate assembly of the ribosomal protein into ribosomes interacts genetically with translation factor eIF2B ZYRO0C04048g weakly similar to uniprot|Q6Q540 Saccharomyces cerevisiae YDR184C ATC1 Nuclear protein possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern ZYRO0C04070g similar to uniprot|P35200 Saccharomyces cerevisiae YLR168C possibly involved in intramitochondrial sorting ZYRO0C04092g similar to uniprot|Q6B217 Saccharomyces cerevisiae YLR246W ERF2 Subunit of a palmitoyltransferase composed of Erf2p and Shr5p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage mutants partially mislocalize Ras2p to the vacuole ZYRO0C04114g some similarities with uniprot|Q04007 Saccharomyces cerevisiae YDR186C Hypothetical ORF ZYRO0C04136g similar to uniprot|Q06549 Saccharomyces cerevisiae YLR245C CDD1 Cytidine deaminase catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified localizes to both the nucleus and cytoplasm ZYRO0C04158g highly similar to uniprot|Q01662 Saccharomyces cerevisiae YLR244C MAP1 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map2p ZYRO0C04180g highly similar to uniprot|P39079 Saccharomyces cerevisiae YDR188W CCT6 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p essential protein that is required for the assembly of actin and tubulins in vivo contains an ATP-binding motif ZYRO0C04202g similar to uniprot|P22213 Saccharomyces cerevisiae YDR189W SLY1 Hydrophilic protein involved in vesicle trafficking between the ER and Golgi SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex ZYRO0C04224g highly similar to uniprot|Q03940 Saccharomyces cerevisiae YDR190C RVB1 RUVB-like protein TIP49a Homologue ZYRO0C04246g similar to uniprot|P53688 Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD()-dependent protein deacetylases involved along with Hst3p in silencing at telomeres cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism ZYRO0C04268g highly similar to uniprot|Q06543 Saccharomyces cerevisiae YLR243W Protein required for cell viability ZYRO0C04290g weakly similar to uniprot|P49686 Saccharomyces cerevisiae YDR192C NUP42 Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side ZYRO0C04312g similar to uniprot|Q2VQX3 Saccharomyces cerevisiae YLR242C ZYRO0C04334g similar to uniprot|Q06538 Saccharomyces cerevisiae YLR241W Hypothetical ORF ZYRO0C04356g similar to uniprot|P22543 Saccharomyces cerevisiae YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; similar to p110 subunit of mammalian PI 3-kinase ZYRO0C04378g similar to uniprot|P15424 Saccharomyces cerevisiae YDR194C MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns presumed RNA helicase due to DEAD-box motif ZYRO0C04400g similar to gnl|GLV|KLLA0D18689g Kluyveromyces lactis KLLA0D18689g and weakly similar to YDR195W uniprot|P42073 Saccharomyces cerevisiae YDR195W REF2 RNA- binding protein involved in the cleavage step of mRNA 3'- end formation prior to polyadenylation also involved in snoRNA maturation ZYRO0C04422g similar to uniprot|Q03941 Saccharomyces cerevisiae YDR196C predicted to catalyze the final step in synthesis of Coenzyme A ZYRO0C04444g similar to uniprot|P14905 Saccharomyces cerevisiae YDR197W CBS2 Translational activator of COB mRNA soluble protein cytochrome b translational activator ZYRO0C04466g similar to uniprot|Q03942 Saccharomyces cerevisiae YDR198C Hypothetical ORF ZYRO0C04488g similar to uniprot|Q06005 Saccharomyces cerevisiae YLR239C LIP2 Lipoyl ligase involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups ZYRO0C04510g weakly similar to uniprot|Q03944 Saccharomyces cerevisiae YDR200C VPS64 ZYRO0C04532g similar to uniprot|Q03954 Saccharomyces cerevisiae YDR201W SPC19 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle ZYRO0C04554g similar to uniprot|Q03956 Saccharomyces cerevisiae YDR202C RAV2 Subunit of RAVE (Rav1p Rav2p Skp1p) a complex that associates with the V1 domain of the vacuolar membrane (H)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme ZYRO0C04576g similar to uniprot|O13525 Saccharomyces cerevisiae YDR204W COQ4 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis possibly functioning in stabilization of Coq7p located on the matrix face of the mitochondrial inner membrane ZYRO0C04598g similar to uniprot|Q05998 YLR237W Saccharomyces cerevisiae THI7 Plasma membrane transporter responsible for the uptake of thiamine ZYRO0C04620g similar to uniprot|Q03455 Saccharomyces cerevisiae YDR205W MSC2 Member of the cation diffusion facilitator family localizes to the endoplasmic reticulum and nucleus mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids ZYRO0C04642g highly similar to uniprot|P13099 Saccharomyces cerevisiae YLR234W TOP3 DNA Topoisomerase III ZYRO0C04664g weakly similar to uniprot|Q03466 Saccharomyces cerevisiae YDR206W ZYRO0C04686g some similarities with uniprot|P39001 Saccharomyces cerevisiae YDR207C UME6 Regulator of both repression and induction of early meiotic genes. Ume6p requires Ume4 for mitotic repression and interacts with and requires Ime1p and Rim11p for induction of meiosis-specific transcription Ume6p is a C6 zinc finger URS1-binding protein. ZYRO0C04708g similar to uniprot|Q05979 Saccharomyces cerevisiae YLR231C BNA5 Kynureninase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway ZYRO0C04730g similar to uniprot|P38994 Saccharomyces cerevisiae YDR208W MSS4 Phosphatidylinositol-4-phosphate 5-kinase involved in actin cytoskeleton organization and cell morphogenesis multicopy suppressor of stt4 mutation ZYRO0C04752g uniprot|P13778 Zygosaccharomyces rouxii P Trans-acting factor B ZYRO0C04774g similar to uniprot|Q03482 Saccharomyces cerevisiae YDR210W Protein of unknown function ZYRO0C04818g highly similar to uniprot|P11154 Saccharomyces cerevisiae YGL062W PYC1 and to YBR218C uniprot|P32327 Saccharomyces cerevisiae YBR218C PYC2 converts pyruvate to oxaloacetate pyruvate carboxylase ZYRO0C04840g similar to uniprot|P53168 Saccharomyces cerevisiae YGL061C DUO1 Essential mitotic spindle protein required to maintain spindle integrity and kinetochore function part of the multisubunit DASH complex which binds microtubules and is transferred to the kinetochore prior to mitosis ZYRO0C04862g similar to uniprot|P38316 Saccharomyces cerevisiae YBR217W ATG12 Protein that becomes conjugated to Atg5p by the E1 enzyme Atg7p a step that is essential for autophagy ZYRO0C04884g similar to uniprot|P38315 Saccharomyces cerevisiae YBR216C YBP1 and to uniprot|P53169 Saccharomyces cerevisiae YGL060W YBP2 ZYRO0C04906g weakly similar to uniprot|Q01448 Saccharomyces cerevisiae YBR215W HPC2 Highly charged basic protein required for normal cell-cycle regulation of histone gene transcription mutants display strong synthetic defects with subunits of FACT a complex that allows RNA Pol II to elongate through nucleosomes ZYRO0C04928g highly similar to uniprot|P53170 Saccharomyces cerevisiae YGL059W Hypothetical ORF ZYRO0C04950g similar to uniprot|P06104 Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2) involved in postreplication repair (with Rad18p) sporulation telomere silencing and ubiquitin-mediated N-end rule protein degradation (with Ubr1p) ZYRO0C04972g weakly similar to uniprot|P53171 Saccharomyces cerevisiae YGL057C Hypothetical ORF ZYRO0C04994g similar to uniprot|P53172 Saccharomyces cerevisiae YGL056C SDS23 Spindle pole body protein and similar to YBR214W uniprot|P38314 Saccharomyces cerevisiae YBR214W SDS24 Nuclear protein with similarity to S. pombe Sds23, suppresses dis2 mutations ZYRO0C05016g similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria ZYRO0C05038g similar to uniprot|P15807 Saccharomyces cerevisiae YBR213W MET8 Bifunctional dehydrogenase and ferrochelatase involved in the biosynthesis of siroheme also involved in the expression of PAPS reductase and sulfite reductase ZYRO0C05060g similar to uniprot|Q75EC3 Ashbya gossypii AAR151W AAR151Wp and weakly similar to YBR212W uniprot|P32831 Saccharomyces cerevisiae YBR212W NGR1 negative growth regulatory protein ZYRO0C05104g some similarities with uniprot|P38313 Saccharomyces cerevisiae YBR211C AME1 associated with microtubules and essential regulator of microtubule stability ZYRO0C05126g highly similar to uniprot|P53173 Saccharomyces cerevisiae YGL054C ERV14 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo required for the delivery of bud-site selection protein Axl2p to cell surface related to Drosophila cornichon ZYRO0C05170g weakly similar to uniprot|P54867 Saccharomyces cerevisiae YOR008C SLG1 Protein involved in cell wall integrity and stress response ZYRO0C05192g similar to Q08977 YPL260W uniprot|Q7LGU3 Saccharomyces cerevisiae Hypothetical ORF ZYRO0C05214g some similarities with uniprot|P40553 Saccharomyces cerevisiae YIL010W DOT5 Nuclear thiol peroxidase ZYRO0C05236g highly similar to uniprot|Q00776 Saccharomyces cerevisiae YPL259C APM1 medium subunit of the clathrin-associated protein complex ZYRO0C05258g some similarities with uniprot|Q03096 Saccharomyces cerevisiae YIL009C-A ZYRO0C05324g highly similar to gnl|GLV|KLLA0D14201g Kluyveromyces lactis KLLA0D14201g and similar to YNL104C uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2-isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway ZYRO0C05346g similar to uniprot|P40554 YIL008W Saccharomyces cerevisiae URM1 Ubiquitin-like protein with only weak sequence similarity to ubiquitin ZYRO0C05368g similar to uniprot|P40555 Saccharomyces cerevisiae YIL007C ZYRO0C05390g highly similar to uniprot|P23644 Saccharomyces cerevisiae YMR203W TOM40 Essential component of the preprotein translocase of the mitochondrial outer membrane (TOM complex) in which it constitutes the core element of the protein conducting pore ZYRO0C05412g similar to uniprot|P33308 Saccharomyces cerevisiae YNR010W CSE2 Component of the Med9/10 module which is a subcomplex within the RNA polymerase II Mediator complex required for regulation of RNA polymerase II activity ZYRO0C05434g highly similar to uniprot|P32352 Saccharomyces cerevisiae YMR202W ERG2 C-8 sterol isomerase catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis ZYRO0C05456g weakly similar to uniprot|P53718 Saccharomyces cerevisiae YNR009W Hypothetical ORF ZYRO0C05478g similar to uniprot|P40345 Saccharomyces cerevisiae YNR008W LRO1 Acyltransferase that catalyzes diacylglycerol esterification one of several acyltransferases that contribute to triglyceride synthesis putative homolog of human lecithin cholesterol acyltransferase ZYRO0C05500g similar to uniprot|P40344 Saccharomyces cerevisiae YNR007C ATG3 Protein involved in autophagy E2-like enzyme that plays a role in formation of Atg8p-phosphatidylethanolamine conjugates which are involved in membrane dynamics during autophagy ZYRO0C05522g similar to uniprot|P28519 Saccharomyces cerevisiae YMR201C RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) contains zinc finger motif homolog of human XPA protein ZYRO0C05544g some similarities with uniprot|P40343 Saccharomyces cerevisiae YNR006W VPS27 hydrophilic protein has cysteine rich putative zinc finger esential for function ZYRO0C05566g similar to uniprot|Q03691 Saccharomyces cerevisiae YMR200W ROT1 Protein that may be involved in cell wall function mutations in rot1 cause cell wall defects suppress tor2 mutations and are synthetically lethal with rot2 mutations ZYRO0C05588g similar to uniprot|P20437 Saccharomyces cerevisiae YMR199W CLN1 role in cell cycle START G(sub)1 cyclin ZYRO0C05610g no similarity ZYRO0C05632g weakly similar to uniprot|Q12365 Saccharomyces cerevisiae YPL255W BBP1 Protein required for the spindle pole body (SPB) duplication localized at the central plaque periphery forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p required for mitotic functions of Cdc5p ZYRO0C05654g similar to uniprot|Q12060 Saccharomyces cerevisiae YPL254W HFI1 Adaptor protein required for structural integrity of the SAGA complex a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions ZYRO0C05676g weakly similar to uniprot|Q01649 Saccharomyces cerevisiae YMR198W CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle is essential for karyogamy and expression is regulated by KAR4 and mating spindle pole body associated protein and to uniprot|Q12045 YPL253C VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion ZYRO0C05698g similar to uniprot|Q12184 Saccharomyces cerevisiae YPL252C YAH1 Iron-sulfur protein of the mitochondrial matrix homologous to human adrenodoxin involved in heme a biosynthesis ZYRO0C05720g similar to uniprot|Q04338 Saccharomyces cerevisiae YMR197C VTI1 Involved in cis-Golgi membrane traffic Vti1p is a v-SNARE that interacts with two t-SNARES Sed5p and Pep12p ZYRO0C05742g similar to uniprot|Q04336 Saccharomyces cerevisiae YMR196W Hypothetical ORF ZYRO0C05764g no similarity ZYRO0C05786g no similarity ZYRO0C05808g some similarities with uniprot|Q04329 Saccharomyces cerevisiae YMR195W ZYRO0C05830g similar to uniprot|Q3E7A9 Saccharomyces cerevisiae YMR194C-B ZYRO0C05852g conserved hypothetical protein ZYRO0C05874g some similarities with uniprot|Q03758 Saccharomyces cerevisiae YML111W BUL2 Component of the Rsp5p E3-ubiquitin ligase complex involved in intracellular amino acid permease sorting functions in heat shock element mediated gene expression essential for growth in stress conditions functional homolog of BUL1 ZYRO0C05896g some similarities with uniprot|Q03758 Saccharomyces cerevisiae YML111W BUL2 Component of the Rsp5p E3-ubiquitin ligase complex involved in intracellular amino acid permease sorting functions in heat shock element mediated gene expression essential for growth in stress conditions functional homolog of BUL1 ZYRO0C05918g highly similar to uniprot|P05745 Saccharomyces cerevisiae YMR194W RPL36A and to uniprot|O14455 Saccharomyces cerevisiae YPL249C-A RPL36B Proteins component of the large (60S) ribosomal subunit ZYRO0C05940g similar to uniprot|P36525 Saccharomyces cerevisiae YMR193W MRPL24 Mitochondrial ribosomal protein of the large subunit ZYRO0C05962g highly similar to uniprot|P08456 Saccharomyces cerevisiae YER026C CHO1 phosphatidylserine synthase ZYRO0C06006g similar to uniprot|P09620 Saccharomyces cerevisiae YGL203C KEX1 Protease involved in the processing of killer toxin and alpha factor precursor cleaves Lys and Arg residues from the C-terminus of peptides and proteins ZYRO0C06028g highly similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase expression is regulated by general control of amino acid biosynthesis ZYRO0C06050g highly similar to uniprot|P06738 Saccharomyces cerevisiae YPR160W GPH1 Non-essential glycogen phosphorylase required for the mobilization of glycogen activity is regulated by cyclic AMP-mediated phosphorylation expression is regulated by stress-response elements and by the HOG MAP kinase pathway ZYRO0C06072g highly similar to uniprot|P53091 Saccharomyces cerevisiae YGL201C MCM6 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex ZYRO0C06138g similar to uniprot|P24869 Saccharomyces cerevisiae YPR119W CLB2 Involved in mitotic induction G(sub)2-specific B-type cyclin and uniprot|P24868 Saccharomyces cerevisiae YGR108W CLB1 ZYRO0C06160g similar to uniprot|P30283 Saccharomyces cerevisiae YPR120C CLB5 B-type cyclin with a role in DNA replication during S phase has an additional functional role in formation of mitotic spindles along with Clb3p and Clb4p and uniprot|P32943 Saccharomyces cerevisiae YGR109C CLB6 ZYRO0C06204g conserved hypothetical protein ZYRO0C06248g no similarity ZYRO0C06270g similar to uniprot|P53264 Saccharomyces cerevisiae YGR110W Hypothetical ORF ZYRO0C06292g no similarity ZYRO0C06336g similar to uniprot|P40851 Saccharomyces cerevisiae YPR122W AXL1 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone required for axial budding pattern of haploid cells ZYRO0C06358g similar to uniprot|P53265 Saccharomyces cerevisiae YGR111W Hypothetical ORF ZYRO0C06380g similar to uniprot|P53266 Saccharomyces cerevisiae YGR112W ZYRO0C06402g similar to uniprot|P53267 Saccharomyces cerevisiae YGR113W DAM1 Component of the DASH complex localized to intranuclear spindles and spindle pole bodies interacts with Duo1p and Mps1p key Ipl1p target for regulating kinetochore-microtubule attachments ZYRO0C06424g similar to gnl|GLV|KLLA0B11407g Kluyveromyces lactis KLLA0B11407g and weakly similar to YPR124W uniprot|P49573 Saccharomyces cerevisiae YPR124W CTR1 High- affinity copper transporter of the plasma membrane mediates nearly all copper uptake under low copper conditions transcriptionally induced at low copper levels and degraded at high copper levels ZYRO0C06446g highly similar to uniprot|P23615 Saccharomyces cerevisiae YGR116W SPT6 Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation ZYRO0C06468g similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W Hypothetical ORF ZYRO0C06490g similar to uniprot|Q06497 Saccharomyces cerevisiae YPR128C ANT1 Peroxisomal adenine nucleotide transporter involved in beta-oxidation of medium-chain fatty acid required for peroxisome proliferation ZYRO0C06512g conserved hypothetical protein ZYRO0C06534g similar to uniprot|Q03337 Saccharomyces cerevisiae YDR472W TRS31 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic ZYRO0C06556g similar to uniprot|P07347 Saccharomyces cerevisiae YHR013C ARD1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing ZYRO0C06600g similar to uniprot|P38759 Saccharomyces cerevisiae YHR012W VPS29 Protein involved in vacuolar protein sorting ZYRO0C06622g similar to uniprot|P38705 Saccharomyces cerevisiae YHR011W DIA4 Probable mitochondrial seryl-tRNA synthetase ZYRO0C06644g highly similar to uniprot|P38706 Saccharomyces cerevisiae YHR010W RPL27A and to uniprot|P38706 Saccharomyces cerevisiae YDR471W RPL27B proteins component of the large (60S) ribosomal subunit ZYRO0C06666g conserved hypothetical protein ZYRO0C06688g similar to uniprot|Q03327 Saccharomyces cerevisiae YDR470C UGO1 ZYRO0C06710g some similarities with uniprot|Q03323 Saccharomyces cerevisiae YDR469W ZYRO0C06732g similar to uniprot|Q03322 Saccharomyces cerevisiae YDR468C TLG1 member of the syntaxin family of t-SNAREs tSNARE that affects a Late Golgi compartment ZYRO0C06754g similar to uniprot|P38758 Saccharomyces cerevisiae YHR009C Hypothetical ORF ZYRO0C06776g some similarities with uniprot|Q03306 Saccharomyces cerevisiae YDR466W ZYRO0C06798g highly similar to uniprot|P00447 Saccharomyces cerevisiae YHR008C SOD2 Manganese-containing superoxide dismutase ZYRO0C06820g similar to uniprot|Q03305 Saccharomyces cerevisiae YDR465C RMT2 Arginine methyltransferase ribosomal protein L12 is a substrate ZYRO0C06842g weakly similar to uniprot|Q06150 Saccharomyces cerevisia YLR267W ZYRO0C06864g similar to uniprot|Q99321 Saccharomyces cerevisiae YOR163W DDP1 Diadenosine polyphosphate hydrolase member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates required for efficient hydrolysis of diphosphorylated inositol polyphosphates ZYRO0C06886g highly similar to uniprot|Q12125 Saccharomyces cerevisiae YOR164C Hypothetical ORF ZYRO0C06908g similar to uniprot|Q99287 Saccharomyces cerevisiae YOR165W SEY1 Synthetic Enhancement with YOP1 ZYRO0C06930g weakly similar to uniprot|Q0P707 Saccharomyces cerevisiae YLR265C ZYRO0C06952g similar to uniprot|Q12104 Saccharomyces cerevisiae YOR166C Hypothetical ORF ZYRO0C06996g weakly similar to uniprot|P14291 Saccharomyces cerevisiae YLR263W RED1 Protein involved in chromosome segregation during the first meiotic division ZYRO0C07018g highly similar to uniprot|P13188 Saccharomyces cerevisiae YOR168W GLN4 Glutamine tRNA synthetase monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu) N-terminal domain proposed to be involved in enzyme-tRNA interactions ZYRO0C07040g highly similar to uniprot|Q3E764 Saccharomyces cerevisiae YLR262C-A ZYRO0C07062g highly similar to uniprot|Q99260 Saccharomyces cerevisiae YLR262C YPT6 Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi; has similarity to the human GTPase, Rab6 ZYRO0C07084g similar to uniprot|Q12246 Saccharomyces cerevisiae YLR260W LCB5 Minor sphingoid long-chain base kinase paralog of Lcb4p responsible for few percent of the total activity possibly involved in synthesis of long-chain base phosphates which function as signaling molecules and similar to YOR171c ZYRO0C07106g highly similar to uniprot|P19882 Saccharomyces cerevisiae YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL ZYRO0C07128g no similarity ZYRO0C07172g weakly similar to uniprot|Q04712 Saccharomyces cerevisiae YML043C RRN11 rDNA transcription factor CF component which also contains Rrn6p and Rrn7p which is required for rDNA transcription by RNA polymerase I component of rDNA transcription factor ZYRO0C07194g similar to uniprot|Q08109 Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins genetically linked to the unfolded protein response (UPR) regulated through association with Hrd3p contains an H2 ring finger ZYRO0C07216g highly similar to uniprot|Q12692 Saccharomyces cerevisiae YOL012C HTZ1 Histone variant H2AZ exchanged for histone H2A in nucleosomes by the SWR1 complex involved in transcriptional regulation through prevention of the spread of silent heterochromatin ZYRO0C07238g similar to uniprot|P39105 Saccharomyces cerevisiae YMR008C PLB1 Phospholipase B (lysophospholipase) involved in lipid metabolism required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol ZYRO0C07282g similar to uniprot|P50105 Saccharomyces cerevisiae YMR005W TAF4 TFIID subunit (48 kDa) involved in RNA polymerase II transcription initiation potential Cdc28p substrate ZYRO0C07304g highly similar to uniprot|Q08096 Saccharomyces cerevisiae YOL010W RCL1 RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0 A1 and A2 does not possess detectable RNA cyclase activity ZYRO0C07326g similar to uniprot|P40959 Saccharomyces cerevisiae YMR004W MVP1 Protein required for sorting proteins to the vacuole overproduction of Mvp1p suppresses several dominant VPS1 mutations Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole ZYRO0C07348g similar to uniprot|Q92328 Saccharomyces cerevisiae YOL009C MDM12 Required for normal mitochondrial morphology and distribution Mdm12p is a mitochondrial outer membrane protein. An Mdm12p homolog exists in S. Pombe which confers a dominant negative phenotype when expressed in S. cerevisiae ZYRO0C07370g similar to uniprot|Q08058 Saccharomyces cerevisiae YOL008W Hypothetical ORF ZYRO0C07392g some similarities with uniprot|Q03673 Saccharomyces cerevisiae YMR003W ZYRO0C07414g similar to uniprot|Q03667 Saccharomyces cerevisiae YMR002W Hypothetical ORF ZYRO0C07436g weakly similar to uniprot|Q08054 Saccharomyces cerevisiae YOL007C Appears to be a structural component of the chitin synthase 3 complex ZYRO0C07458g similar to uniprot|P04786 Saccharomyces cerevisiae YOL006C TOP1 topoisomerase I ZYRO0C07480g highly similar to uniprot|P32562 Saccharomyces cerevisiae YMR001C ZYRO0C07502g highly similar to uniprot|P38902 Saccharomyces cerevisiae YOL005C ZYRO0C07524g similar to uniprot|P22579 Saccharomyces cerevisiae YOL004W SIN3 DNA binding protein involved in transcriptional regulation ZYRO0C07546g similar to uniprot|Q12006 Saccharomyces cerevisiae YOL003C DHHC-CRD protein ZYRO0C07612g similar to uniprot|Q12442 Saccharomyces cerevisiae YOL002C IZH2 Membrane protein involved in zinc metabolism member of the four-protein IZH family direct target of the Zap1p transcription factor expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc ZYRO0C07634g similar to uniprot|P20052 Saccharomyces cerevisiae YOL001W PHO80 Cyclin negatively regulates phosphate metabolism Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p deletion of PHO80 leads to aminoglycoside supersensitivity truncated form of PHO80 affects vacuole inheritance ZYRO0C07678g similar to uniprot|Q12149 Saccharomyces cerevisiae YOR001W RRP6 Exonuclease component of the nuclear exosome contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus ZYRO0C07700g highly similar to uniprot|P32939 Saccharomyces cerevisiae YML001W YPT7 Gtp-binding protein of the rab family required for homotypic fusion event in vacuole inheritance for endosome-endosome fusion and for fusion of endosomes to vacuoles when expressed from high copy plasmid GTP-binding protein rab family ZYRO0C07722g conserved hypothetical protein ZYRO0C07744g highly similar to uniprot|Q12001 Saccharomyces cerevisiae YOR002W ALG6 Glucosyltransferase involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation mutations in human ortholog are associated with disease ZYRO0C07788g similar to uniprot|Q12118 Saccharomyces cerevisiae YOR007C SGT2 Glutamine-rich cytoplasmic protein of unknown function contains tetratricopeptide (TPR) repeats which often mediate protein-protein interactions conserved in human and C. elegans ZYRO0C07810g similar to uniprot|Q04257 Saccharomyces cerevisiae YML003W/YML002W Hypothetical ORF ZYRO0C07832g similar to uniprot|Q12094 Saccharomyces cerevisiae YOR006C Hypothetical ORF ZYRO0C07854g similar to uniprot|Q08387 Saccharomyces cerevisiae YOR005C DNL4 DNA ligase required for nonhomologous end-joining (NHEJ) forms stable heterodimer with required cofactor Lif1p catalyzes DNA ligation as part of a complex with Lif1p and Nej1p involved in meiosis not essential for vegetative growth ZYRO0C07876g similar to uniprot|P39923 Saccharomyces cerevisiae YEL062W NPR2 Regulator of nitrogen permeases transcription is induced in response to proline and urea contains two PEST sequences ZYRO0C07898g some similarities with uniprot|P27895 Saccharomyces cerevisiae YEL061C CIN8 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation ZYRO0C07920g similar to uniprot|Q12339 Saccharomyces cerevisiae YOR004W Protein required for cell viability ZYRO0C07942g similar to uniprot|P09232 Saccharomyces cerevisiae YEL060C PRB1 Vacuolar proteinase B (yscB) a serine protease of the subtilisin family involved in protein degradation in the vacuole and required for full protein degradation during sporulation ZYRO0C07964g highly similar to uniprot|P08417 Saccharomyces cerevisiae YPL262W FUM1 Fumarase converts fumaric acid to L-malic acid in the TCA cycle cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation ZYRO0C07986g similar to uniprot|P53273 Saccharomyces cerevisiae YGR125W Hypothetical ORF ZYRO0C08008g similar to uniprot|Q757Z5 Ashbya gossypii AEL135C AEL135Cp and some similarites with YJL176C uniprot|P32591 Saccharomyces cerevisiae YJL176C SWI3 transcription factor ZYRO0C08030g similar to uniprot|P34237 Saccharomyces cerevisiae YKL179C ZYRO0C08052g highly similar to uniprot|P46990 Saccharomyces cerevisiae YJL177W ZYRO0C08074g similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high- dosage growth inhibitor; forms a homotrimer in vitro ZYRO0C08096g similar to uniprot|Q02771 Saccharomyces cerevisiae YER058W PET117 Protein required for assembly of cytochrome c oxidase ZYRO0C08118g similar to uniprot|P40186 Saccharomyces cerevisiae YIL050W PCL7 Pho85p cyclin of the Pho80p subfamily forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p involved in glycogen metabolism expression is cell-cycle regulated ZYRO0C08140g similar to uniprot|P40039 Saccharomyces cerevisiae YER060W FCY2 Purine-cytosine permease and similar to uniprot|P17064 Saccharomyces cerevisiae YER056C ZYRO0C08162g similar to uniprot|P39525 Saccharomyces cerevisiae YER061C CEM1 homology with beta-keto-acyl synthases Protein homologous to beta-keto-acyl synthase ZYRO0C08184g similar to uniprot|P41277 Saccharomyces cerevisiae RHR2 and to YER062C uniprot|P40106 Saccharomyces cerevisiae HOR2, two redundant DL-glycerol-3-phosphatases ZYRO0C08206g weakly similar to uniprot|P40040 Saccharomyces cerevisiae YER063W THO1 Suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) (putative) involved in transcription ZYRO0C08228g some similarities with uniprot|P40523 Saccharomyces cerevisiae YIL055C Hypothetical ORF ZYRO0C08250g weakly similar to uniprot|P40522 Saccharomyces cerevisiae YIL056W Hypothetical ORF and to uniprot|P40041 Saccharomyces cerevisiae YER064C Non-essential nuclear protein; null mutation has global effects on transcription ZYRO0C08272g highly similar to uniprot|P28240 Saccharomyces cerevisiae YER065C ICL1 Isocitrate lyase catalyzes the formation of succinate and glyoxylate from isocitrate a key reaction of the glyoxylate cycle expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose ZYRO0C08316g no similarity ZYRO0C08338g similar to uniprot|P40043 Saccharomyces cerevisiae YER067W Hypothetical ORF ZYRO0C08360g similar to uniprot|P34909 Saccharomyces cerevisiae YER068W MOT2 Component of the CCR4-NOT transcription regulatory complex which represses transcription at least in part by inhibiting functional TBP-DNA interactions and also aids in transcription elongation interacts with C-terminal region of Not1p ZYRO0C08382g similar to uniprot|Q00916 Saccharomyces cerevisiae YIL061C SNP1 U1snRNP 70K protein homolog ZYRO0C08404g highly similar to uniprot|Q01217 Saccharomyces cerevisiae YER069W ARG5 6 Bifunctional enzyme with acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase activities catalyzes the second and third steps in the biosynthesis of the arginine precursor ornithine forms a complex with Arg2p ZYRO0C08426g similar to uniprot|P40518 Saccharomyces cerevisiae YIL062C ARC15 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches ZYRO0C08448g some similarities with uniprot|P40517 Saccharomyces cerevisiae YIL063C YRB2 Ran-GTPase-binding protein involved in nuclear export nuclear protein interacts with Gsp1p and Crm1p ZYRO0C08470g similar to uniprot|P40516 Saccharomyces cerevisiae YIL064W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family ZYRO0C08492g similar to uniprot|P40515 Saccharomyces cerevisiae YIL065C FIS1 Mitochondrial outer membrane protein involved in membrane fission required for localization of Dnm1p and Mdv1p during mitochondrial division ZYRO0C08514g highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits ZYRO0C08536g similar to uniprot|P40514 Saccharomyces cerevisiae YIL067C Hypothetical ORF ZYRO0C08558g similar to uniprot|P32844 Saccharomyces cerevisiae YIL068C SEC6 Essential 88kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis ZYRO0C08580g similar to uniprot|P40045 Saccharomyces cerevisiae YER071C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0C08602g highly similar to uniprot|P40046 Saccharomyces cerevisiae YER072W VTC1 Protein involved in vacuolar maintenance ZYRO0C08646g highly similar to uniprot|P40047 Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase that is activated by K and utilizes NADP as the preferred coenzyme ZYRO0C08668g highly similar to uniprot|P26782 Saccharomyces cerevisiae YIL069C RPS24B proteins component of the small (40S) ribosomal subunit ZYRO0C08690g highly similar to uniprot|Q3E834 Saccharomyces cerevisiae YER074W-A ZYRO0C08712g similar to uniprot|P40048 Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the cytoplasm ZYRO0C08756g similar to uniprot|P40513 Saccharomyces cerevisiae YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation related to the human complement receptor gC1q-R ZYRO0C08778g similar to uniprot|P40050 Saccharomyces cerevisiae YER077C Hypothetical ORF ZYRO0C08800g similar to uniprot|P40512 Saccharomyces cerevisiae YIL071C PCI8 Possible shared subunit of Cop9 signalosome (CSN) and eIF3 binds eIF3b subunit Prt1p has possible dual functions in transcriptional and translational control contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain ZYRO0C08822g similar to uniprot|P40051 Saccharomyces cerevisiae YER078C Hypothetical ORF ZYRO0C08844g similar to uniprot|P20050 Saccharomyces cerevisiae YIL072W HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex required for homologous chromosome synapsis and chiasma formation ZYRO0C08866g similar to gnl|GLV|KLLA0C07601g Kluyveromyces lactis KLLA0C07601g and some similarities with YER079W uniprot|P40052 Saccharomyces cerevisiae YER079W Hypothetical ORF ZYRO0C08888g similar to uniprot|P40053 Saccharomyces cerevisiae YER080W FMP29 The authentic non-tagged protein was localized to the mitochondria ZYRO0C08910g similar to uniprot|P40511 Saccharomyces cerevisiae YIL073C ZYRO0C08932g highly similar to uniprot|P40510 and to YER081W uniprot|P40054 Saccharomyces cerevisiae SER3 3-phosphoglycerate dehydrogenase, catalyze the first step in serine and glycine biosynthesis; isozyme of Ser33p ZYRO0C08954g similar to uniprot|P32565 Saccharomyces cerevisiae YIL075C RPN2 Subunit of the 26S proteasome substrate of the N-acetyltransferase Nat1p ZYRO0C08976g highly similar to uniprot|P40055 Saccharomyces cerevisiae YER082C ZYRO0C08998g similar to uniprot|Q6V3W9 Saccharomyces kluyveri URA9 Dihydroorotate dehydrogenase mitochondrial precursor ZYRO0C09020g similar to uniprot|P40056 Saccharomyces cerevisiae YER083C RMD7 Required for Meiotic nuclear Division functions in DNA replication and damage response Protein involved in cell wall function ZYRO0C09042g similar to uniprot|P40509 Saccharomyces cerevisiae YIL076W SEC28 Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells coatomer forms the COP I vesicle coat whose functions are essential epsilon-COP coatomer subunit Sec28p ZYRO0C09064g similar to uniprot|P40508 Saccharomyces cerevisiae YIL077C Hypothetical ORF ZYRO0C09086g highly similar to uniprot|P04801 Saccharomyces cerevisiae YIL078W THS1 Threonyl-tRNA synthetase cytoplasmic ZYRO0C09108g similar to Saccharomyces cerevisiae YDL175C and to uniprot|P40507 Saccharomyces cerevisiae YIL079C ZYRO0C09130g similar to uniprot|Q07549 Saccharomyces cerevisiae YDL123W SNA4 Protein of unknown function localized to the vacuolar outer membrane ZYRO0C09152g similar to uniprot|Q12027 Saccharomyces cerevisiae YDL176W Hypothetical ORF ZYRO0C09174g similar to uniprot|Q12257 Saccharomyces cerevisiae YDL177C Hypothetical ORF ZYRO0C09196g highly similar to uniprot|Q07551 Saccharomyces cerevisiae YDL124W NADPH-dependent alpha-keto amide reductase reduces aromatic alpha-keto amides aliphatic alpha-keto esters and aromatic alpha-keto esters ZYRO0C09218g highly similar to uniprot|P46681 Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase located in the mitochondrial matrix ZYRO0C09240g similar to uniprot|Q04344 Saccharomyces cerevisiae YDL125C ZYRO0C09262g highly similar to uniprot|P25694 Saccharomyces cerevisiae YDL126C CDC48 ATPase in ER nuclear membrane and cytosol with homology to mammalian p97 in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome ZYRO0C09284g some similarities with uniprot|P25693 Saccharomyces cerevisiae YDL127W PCL2 G1 cyclin associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle essential for cell morphogenesis localizes to sites of polarized cell growth ZYRO0C09306g similar to uniprot|O13581 Saccharomyces cerevisiae YDL128W ZYRO0C09328g similar to uniprot|Q12301 Saccharomyces cerevisiae YDL180W Hypothetical ORF ZYRO0C09350g some similarities with uniprot|Q07555 Saccharomyces cerevisiae YDL129W Hypothetical ORF ZYRO0C09372g highly similar to uniprot|P10622 Saccharomyces cerevisiae YDL130W RPP1B Ribosomal protein P1 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component ZYRO0C09394g conserved hypothetical protein ZYRO0C09416g highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase ZYRO0C09438g highly similar to uniprot|Q12018 Saccharomyces cerevisiae YDL132W CDC53 Cullin structural protein of SCF complexes (which also contain Skp1p Cdc34p and an F-box protein) involved in ubiquitination SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation ZYRO0C09460g similar to uniprot|Q12516 Saccharomyces cerevisiae YDL133W ZYRO0C09482g similar to uniprot|P48569 Saccharomyces cerevisiae YDL183C Hypothetical ORF ZYRO0C09504g highly similar to uniprot|P17255 Saccharomyces cerevisiae YDL185W TFP1 Vacuolar ATPase V1 domain subunit A protein precursor is spliced to yield the extein Tfp1p and the intein Vde (PI-SceI) which is a site-specific endonuclease ZYRO0C09548g similar to uniprot|P06779 Saccharomyces cerevisiae YJR052W RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) ZYRO0C09570g some similarities with uniprot|P53882 Saccharomyces cerevisiae YNL176C Hypothetical ORF ZYRO0C09592g similar to uniprot|P53881 Saccharomyces cerevisiae YNL177C MRPL22 Mitochondrial ribosomal protein of the large subunit ZYRO0C09614g similar to uniprot|Q02774 Saccharomyces cerevisiae YDL212W SHR3 Endoplasmic reticulum packaging chaperone required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface ZYRO0C09636g highly similar to uniprot|P05750 Saccharomyces cerevisiae YNL178W RPS3 Protein component of the small (40S) ribosomal subunit ZYRO0C09680g similar to gnl|GLV|KLLA0D08327g Kluyveromyces lactis KLLA0D08327g and some similarites with YNL180C uniprot|P53879 Saccharomyces cerevisiae YNL180C RHO5 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity ZYRO0C09702g similar to uniprot|P53878 Saccharomyces cerevisiae YNL181W Protein required for cell viability ZYRO0C09724g similar to uniprot|P53877 Saccharomyces cerevisiae YNL182C IPI3 Protein required for cell viability computational analysis of large-scale protein-protein interaction data suggests a possible role in assembly of the ribosomal large subunit ZYRO0C09746g similar to uniprot|Q07623 Saccharomyces cerevisiae YDL213C ZYRO0C09768g similar to uniprot|P22211 Saccharomyces cerevisiae YNL183C NPR1 Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation ZYRO0C09790g highly similar to uniprot|P53875 Saccharomyces cerevisiae YNL185C MRPL19 Mitochondrial ribosomal protein of the large subunit ZYRO0C09812g some similarities with uniprot|P53874 Saccharomyces cerevisiae YNL186W UBP10 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties may regulate silencing by acting on Sir4p involved in posttranscriptionally regulating Gap1p and possibly other transporters primarily located in the nucleus ZYRO0C09834g similar to uniprot|P33327 Saccharomyces cerevisiae YDL215C GDH2 NAD()-dependent glutamate dehydrogenase degrades glutamate to ammonia and alpha-ketoglutarate expression sensitive to nitrogen catabolite repression and intracellular ammonia levels ZYRO0C09856g similar to uniprot|Q12468 Saccharomyces cerevisiae YDL216C RRI1 subunit of COP9 signalosome (CSN) COP9 signalosome ZYRO0C09878g similar to uniprot|P53873 Saccharomyces cerevisiae YNL187W Non-essential protein with putative leucine-rich nuclear export signal (NES) sequence that fits the consensus sequence recognized by Crm1p ZYRO0C09900g highly similar to uniprot|Q12328 Saccharomyces cerevisiae YDL217C TIM22 Mitochondrial inner membrane protein involved in import of proteins of the ADP/ATP carrier (AAC) family ZYRO0C09922g some similarities with uniprot|P11927 Saccharomyces cerevisiae YNL188W KAR1 Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis localizes to the half-bridge of the spindle pole body interacts with Spc72p during karyogamy also interacts with Cdc31p ZYRO0C09944g highly similar to uniprot|Q02821 Saccharomyces cerevisiae YNL189W SRP1 karyopherin alpha homolog of 60 kDa ZYRO0C09966g some similarities with uniprot|P53872 Saccharomyces cerevisiae YNL190W Hypothetical ORF ZYRO0C10010g highly similar to uniprot|P53871 Saccharomyces cerevisiae YNL191W Hypothetical ORF ZYRO0C10032g highly similar to uniprot|Q07648 Saccharomyces cerevisiae YDL219W DTD1 D-Tyr-tRNA(Tyr) deacylase functions in protein translation may affect nonsense suppression via alteration of the protein synthesis machinery ubiquitous among eukaryotes ZYRO0C10054g similar to uniprot|P08004 Saccharomyces cerevisiae YNL192W CHS1 Chitin synthase I requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin required for repairing the chitin septum during cytokinesis transcription activated by mating factor ZYRO0C10076g similar to uniprot|P53870 Saccharomyces cerevisiae YNL193W Hypothetical ORF ZYRO0C10098g some similarities with uniprot|P32797 Saccharomyces cerevisiae YDL220C CDC13 Single stranded DNA-binding protein found at TG1-3 telomere G-tails regulates telomere replication through recruitment of specific sub-complexes but the essential function is telomere capping ZYRO0C10120g no similarity ZYRO0C10142g no similarity ZYRO0C10164g some similarities with Saccharomyces cerevisiae YDL224C WHI4 and to uniprot|P34761 Saccharomyces cerevisiae YNL197C WHI3 ZYRO0C10186g similar to uniprot|Q07657 Saccharomyces cerevisiae YDL225W SHS1 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM ZYRO0C10208g weakly similar to uniprot|Q01722 Saccharomyces cerevisiae YNL199C GCR2 Transcriptional activator of genes involved in glycolysis functions and interacts with Gcr1p ZYRO0C10230g highly similar to uniprot|P40165 Saccharomyces cerevisiae YNL200C ZYRO0C10252g similar to uniprot|P40164 Saccharomyces cerevisiae YNL201C PSY2 Nuclear protein of unknown function deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C deletion is synthetically lethal with a chitin synthase (CHS1) null mutant ZYRO0C10274g highly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 late sporulation specific gene which may function during spore wall formation peroxisomal 2 4-dienoyl-CoA reductase ZYRO0C10296g similar to uniprot|P35197 Saccharomyces cerevisiae YDL226C GCS1 ADP-ribosylation factor GTPase activating protein ZYRO0C10318g similar to uniprot|P40161 Saccharomyces cerevisiae YNL206C RTT106 Regulator of Ty1 Transposition - same phenotype as RTT101 - RTT105 disruption causes increase in Ty1 transposition. Isolated from the same screen as the other named RTT genes. ZYRO0C10340g similar to uniprot|P40160 Saccharomyces cerevisiae YNL207W RIO2 Protein required for cell viability ZYRO0C10362g no similarity ZYRO0C10384g weakly similar to uniprot|P40159 Saccharomyces cerevisiae YNL208W ZYRO0C10406g weakly similar to uniprot|Q02933 Saccharomyces cerevisiae YPL123C RNY1 RNAse member of the T(2) family of endoribonucleases ZYRO0C10428g similar to uniprot|P09932 Saccharomyces cerevisiae YDL227C HO Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p Swi5p and Ash1p ZYRO0C10450g uniprot|Q707X3 Zygosaccharomyces rouxii SSB Heat shock protein SSB ZYRO0C10472g some similarities with uniprot|P16523 Saccharomyces cerevisiae YNL210W MER1 Protein with RNA-binding motifs required for meiosis-specific mRNA splicing required for chromosome pairing and meiotic recombination ZYRO0C10494g similar to uniprot|P25044 Saccharomyces cerevisiae YDL230W PTP1 Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo including Fpr3p localized to the cytoplasm and the mitochondria ZYRO0C10516g similar to uniprot|Q07660 Saccharomyces cerevisiae YDL231C BRE4 Zinc finger protein containing five transmembrane domains null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A a drug which is known to affect intracellular transport ZYRO0C10538g similar to uniprot|P53869 Saccharomyces cerevisiae YNL211C ZYRO0C10560g similar to uniprot|P40157 Saccharomyces cerevisiae YNL212W VID27 Vacuole import and degradation ZYRO0C10582g similar to uniprot|P40156 Saccharomyces cerevisiae YNL213C Hypothetical ORF ZYRO0C10604g similar to uniprot|P40155 Saccharomyces cerevisiae YNL214W PEX17 Peroxisomal membrane protein component of the peroxisomal translocation machinery required for peroxisome biogenesis binds Pex14p ZYRO0C10626g some similarities with uniprot|Q07684 Saccharomyces cerevisiae YDL233W Hypothetical ORF ZYRO0C10648g some similarities with uniprot|P40154 Saccharomyces cerevisiae YNL215W IES2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions ZYRO0C10670g similar to uniprot|P48365 Saccharomyces cerevisiae YDL234C GYP7 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective) Ypt1p Ypt31p and Ypt32p (in vitro) involved in vesicle mediated protein trafficking ZYRO0C10692g some similarities with uniprot|P11938 Saccharomyces cerevisiae YNL216W RAP1 DNA-binding protein involved in either activation or repression of transcription depending on binding site context also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure ZYRO0C10736g highly similar to uniprot|Q00711 Saccharomyces cerevisiae YKL148C SDH1 Flavoprotein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone ZYRO0C10758g similar to uniprot|P24309 Saccharomyces cerevisiae YKL149C DBR1 RNA lariat debranching enzyme involved in intron turnover required for efficient Ty1 transposition ZYRO0C10780g similar to uniprot|P36060 Saccharomyces cerevisiae YKL150W MCR1 Mitochondrial NADH-cytochrome b5 reductase involved in ergosterol biosynthesis ZYRO0C10802g similar to uniprot|P36059 Saccharomyces cerevisiae YKL151C Hypothetical ORF ZYRO0C10824g highly similar to uniprot|P00950 Saccharomyces cerevisiae YKL152C GPM1 Tetrameric phosphoglycerate mutase of the glycolytic pathway converts 3-phosphoglycerate to 2-phosphoglycerate ZYRO0C10846g weakly similar to uniprot|P32806 Saccharomyces cerevisiae YJL044C GYP6 GTPase-activating protein (GAP) for the yeast Rab family member Ypt6p involved in vesicle mediated protein transport ZYRO0C10868g similar to uniprot|P43638 Saccharomyces cerevisiae YJL042W MHP1 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase ZYRO0C10890g similar to uniprot|P14907 Saccharomyces cerevisiae YJL041W NSP1 Essential component of the nuclear pore complex which mediates nuclear import and export ZYRO0C10912g similar to uniprot|P47054 Saccharomyces cerevisiae YJL039C NUP192 Essential structural subunit of the nuclear pore complex (NPC) localizes to the nuclear periphery of nuclear pores homologous to human p205 ZYRO0C10978g conserved hypothetical protein ZYRO0C11000g similar to uniprot|P36057 Saccharomyces cerevisiae YKL154W SRP102 Signal recognition particle (SRP) receptor beta subunit involved in SRP-dependent protein targeting anchors Srp101p to the ER membrane. ZYRO0C11022g similar to uniprot|P36056 Saccharomyces cerevisiae YKL155C RSM22 Mitochondrial ribosomal protein of the small subunit ZYRO0C11044g highly similar to uniprot|P38711 Saccharomyces cerevisiae YHR021c RPS27B ribosomal protein and to uniprot|P35997 Saccharomyces cerevisiae YKL156w RPS27A, Protein component of the small (40S) ribosomal subunit ZYRO0C11066g similar to uniprot|P08964 Saccharomyces cerevisiae YHR023W MYO1 Type II myosin heavy chain required for wild-type cytokinesis and cell separation localizes to the actomyosin ring binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively ZYRO0C11088g highly similar to uniprot|P11914 Saccharomyces cerevisiae YHR024C MAS2 Larger subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins ZYRO0C11110g similar to uniprot|P39875 Saccharomyces cerevisiae YOR033C EXO1 5'-3' exonuclease and flap-endonuclease involved in recombination double-strand break repair and DNA mismatch repair member of the Rad2p nuclease family with conserved N and I nuclease domains ZYRO0C11132g similar to uniprot|P39010 Saccharomyces cerevisiae YDR264C AKR1 Palmitoyl transferase involved in protein palmitoylation acts as a negative regulator of pheromone response pathway required for endocytosis of pheromone receptors involved in cell shape control contains ankyrin repeats ZYRO0C11154g similar to uniprot|P51534 Saccharomyces cerevisiae YOR035C SHE4 Protein containing a UCS (UNC-45/CRO1/SHE4) domain binds to myosin motor domains to regulate myosin function involved in endocytosis polarization of the actin cytoskeleton and asymmetric mRNA localization ZYRO0C11176g similar to uniprot|Q05568 Saccharomyces cerevisiae YDR265W PEX10 RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to protein import machinery; mutations in human homolog cause a variety of peroxisomal disorders ZYRO0C11198g similar to uniprot|Q05580 Saccharomyces cerevisiae YDR266C Hypothetical ORF ZYRO0C11220g similar to uniprot|P32854 Saccharomyces cerevisiae YOR036W PEP12 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole controls entry of biosynthetic endocytic and retrograde traffic into the prevacuolar compartment syntaxin ZYRO0C11242g highly similar to uniprot|Q05583 Saccharomyces cerevisiae CIA1 YDR267c Protein required for cell viability ZYRO0C11264g similar to uniprot|P38909 Saccharomyces cerevisiae YOR037W CYC2 Mitochondrial protein required for normal abundance of mitochondrial cytochrome c (Cyc1p) and for mitochondrial osmotic stability may be involved in regulating the activity of cytochrome c heme lyase (Cyc3p) potential Cdc28p substrate ZYRO0C11286g highly similar to uniprot|P04803 YDR268W Saccharomyces cerevisiae MSW1 Mitochondrial tryptophanyl-tRNA synthetase ZYRO0C11308g similar to uniprot|P32480 Saccharomyces cerevisiae YOR038C HIR2 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes recruits Swi-Snf complexes to histone gene promoters promotes heterochromatic gene silencing with Asf1p ZYRO0C11330g highly similar to uniprot|P38930 Saccharomyces cerevisiae YOR039W CKB2 protein kinase CK2 beta' subunit ZYRO0C11352g similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; Cu(2+)-transporting ATPase ZYRO0C11374g similar to uniprot|Q12320 Saccharomyces cerevisiae YOR040W GLO4 Mitochondrial glyoxalase II catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate ZYRO0C11396g similar to uniprot|Q08412 Saccharomyces cerevisiae YOR042W CUE5 Protein containing a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0C11418g similar to uniprot|P53313 Saccharomyces cerevisiae YGR245C SDA1 Severe Depolymerization of Actin ZYRO0C11440g similar to uniprot|P29056 Saccharomyces cerevisiae YGR246C BRF1 TFIIIB B-related factor one of three subunits of RNA polymerase III transcription initiation factor TFIIIB binds TFIIIC and TBP and recruits RNA pol III to promoters amino-terminal half is homologous to TFIIB ZYRO0C11462g similar to uniprot|P53314 Saccharomyces cerevisiae YGR247W CPD1 Cyclic nucleotide phosphodiesterase hydrolyzes ADP-ribose 1'' 2''-cyclic phosphate to ADP- ribose 1''-phosphate no detectable phenotype is conferred by null mutation or by overexpression ZYRO0C11484g similar to uniprot|P53315 Saccharomyces cerevisiae YGR248W ZYRO0C11506g some similarities with uniprot|P53050 Saccharomyces cerevisiae YGR249W ZYRO0C11528g similar to uniprot|P38859 Saccharomyces cerevisiae YHR164C DNA2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase ATP-dependent nuclease and helicase activities required for Okazaki fragment processing involved in DNA repair pathways potential Cdc28p substrate ZYRO0C11550g no similarity ZYRO0C11572g highly similar to uniprot|P33334 Saccharomyces cerevisiae YHR165C PRP8 Component of the U4/U6-U5 snRNP complex involved in the second catalytic step of splicing ZYRO0C11594g similar to uniprot|P16522 Saccharomyces cerevisiae YHR166C CDC23 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition ZYRO0C11616g similar to uniprot|O13539 Saccharomyces cerevisiae YHR167W THP2 affects transcription elongation ZYRO0C11638g similar to uniprot|P38860 Saccharomyces cerevisiae YHR168W MTG2 Putative GTPase member of the Obg family peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit required for mitochondrial translation possibly via a role in ribosome assembly ZYRO0C11660g highly similar to uniprot|P38719 Saccharomyces cerevisiae YHR169W DBP8 Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit ZYRO0C11682g similar to uniprot|P53317 Saccharomyces cerevisiae YGR251W Protein required for cell viability ZYRO0C11704g highly similar to uniprot|P38861 Saccharomyces cerevisiae YHR170W NMD3 Protein involved in nuclear export of the large ribosomal subunit acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex ZYRO0C11726g similar to uniprot|P38862 Saccharomyces cerevisiae YHR171W ATG7 Autophagy-related protein that is a member of the E1 family of ubiquitin-activating enzymes mediates the conjugation of Atg12p with Atg5p a required step in the formation of autophagosomes ZYRO0C11748g highly similar to uniprot|Q03330 Saccharomyces cerevisiae YGR252W GCN5 Histone acetyltransferase acetylates lysine 14 on histone H3 catalytic subunit of the ADA and SAGA histone acetyltransferase complexes founding member of the Gcn5p-related N-acetyltransferase superfamily ZYRO0C11770g highly similar to uniprot|P32379 Saccharomyces cerevisiae YGR253C PUP2 Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit zeta ZYRO0C11792g similar to uniprot|P38863 YHR172W Saccharomyces cerevisiae SPC97 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex ZYRO0C11814g highly similar to uniprot|P00924 Saccharomyces cerevisiae YGR254W ENO1 Enolase I and to uniprot|P00925 Saccharomyces cerevisiae YHR174W ENO2 Enolase II ZYRO0C11836g some similarities with uniprot|P38865 Saccharomyces cerevisiae YHR175W CTR2 ZYRO0C11858g similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins ZYRO0C11880g similar to uniprot|P38699 Saccharomyces cerevisiae YHR178W STB5 binds Sin3p in two-hybrid assay Zinc finger (6-Cys) ZYRO0C11902g highly similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism ZYRO0C11924g similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism ZYRO0C11946g highly similar to uniprot|P53732 Saccharomyces cerevisiae YNR036C ZYRO0C11968g similar to uniprot|P25646 Saccharomyces cerevisiae YCR079W Hypothetical ORF ZYRO0C11990g highly similar to uniprot|P53733 Saccharomyces cerevisiae YNR037C ZYRO0C12012g similar to uniprot|P53734 Saccharomyces cerevisiae YNR038W DBP6 Essential protein involved in ribosome biogenesis putative ATP-dependent RNA helicase of the DEAD-box protein family ZYRO0C12034g similar to uniprot|P25648 Saccharomyces cerevisiae YCR081W SRB8 RNA polymerase II mediator complex subunit ZYRO0C12056g similar to uniprot|P53735 Saccharomyces cerevisiae YNR039C ZRG17 Endoplasmic reticulum protein of unknown function transcription is induced under conditions of zinc deficiency mutant phenotype suggests a role in uptake of zinc ZYRO0C12078g similar to uniprot|P32944 Saccharomyces cerevisiae YJL187C SWE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity localizes to the nucleus and to the daughter side of the mother-bud neck homolog of S. pombe Wee1p potential Cdc28p substrate ZYRO0C12122g highly similar to uniprot|Q3E7Y3 Saccharomyces cerevisiae YLR367W RPS22B and highly similar to uniprot|P0C0W1 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit ZYRO0C12144g highly similar to uniprot|P06367 Saccharomyces cerevisiae YCR031C RPS14A ribosomal protein 59 (rp59) of the small (40S) ribosomal subunit ZYRO0C12166g similar to uniprot|P39543 Saccharomyces cerevisiae YJL192C SOP4 suppressor of pma1-7 ZYRO0C12188g similar to uniprot|P25356 Saccharomyces cerevisiae YCR032W BPH1 ZYRO0C12210g similar to uniprot|P39542 Saccharomyces cerevisiae YJL193W Hypothetical ORF ZYRO0C12232g similar to uniprot|P09119 Saccharomyces cerevisiae YJL194W CDC6 Essential ATP-binding protein required for DNA replication component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association homologous to S. pombe Cdc18p ZYRO0C12254g some similarities with uniprot|P25357 Saccharomyces cerevisiae YCR033W SNT1 ZYRO0C12276g similar to uniprot|P53253 Saccharomyces cerevisiae YGR089W NNF2 Protein that exhibits physical and genetic interactions with Rpb8p which is a subunit of RNA polymerases I II and III computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation ZYRO0C12320g similar to uniprot|P53254 Saccharomyces cerevisiae YGR090W UTP22 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data ZYRO0C12342g similar to uniprot|Q6B2S3 Saccharomyces cerevisiae YPR109W Hypothetical ORF ZYRO0C12364g highly similar to uniprot|P07703 Saccharomyces cerevisiae YPR110C RPC40 RNA polymerase subunit common to RNA polymerase I and III ZYRO0C12386g similar to uniprot|P49704 Saccharomyces cerevisiae YGR091W PRP31 Splicing factor component of the U4/U6-U5 snRNP complex ZYRO0C12408g highly similar to uniprot|P22204 Saccharomyces cerevisiae YGR092W DBF2 Ser/Thr kinase involved in transcription and stress response functions as part of a network of genes in exit from mitosis localization is cell cycle regulated activated by Cdc15p during the exit from mitosis ZYRO0C12430g similar to uniprot|P53255 Saccharomyces cerevisiae YGR093W Hypothetical ORF ZYRO0C12452g similar to uniprot|Q06106 Saccharomyces cerevisiae YPR112C MRD1 Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites shows partial nucleolar localization contains five consensus RNA-binding domains ZYRO0C12474g highly similar to uniprot|P07806 Saccharomyces cerevisiae YGR094W VAS1 mitochondrial and cytoplasmic valyl-tRNA synthetase ZYRO0C12496g similar to uniprot|P53256 Saccharomyces cerevisiae YGR095C RRP46 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'->5' exonucleases ZYRO0C12518g similar to uniprot|P53257 Saccharomyces cerevisiae YGR096W TPC1 Tpc1p is a transporter that catalyzes the uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria it is located in the mitochondrial membrane and its expression appears to be regulated by carbon source ZYRO0C12540g similar to uniprot|P06197 Saccharomyces cerevisiae YPR113W PIS1 Phosphatidylinositol synthase required for biosynthesis of phosphatidylinositol which is a precursor for polyphosphoinositides sphingolipids and glycolipid anchors for some of the plasma membrane proteins ZYRO0C12562g highly similar to uniprot|P00331 Saccharomyces cerevisiae YMR303C ADH2 Glucose-repressible alcohol dehydrogenase II involved in the production of certain carboxylate esters ZYRO0C12584g similar to uniprot|Q06107 Saccharomyces cerevisiae YPR114W Hypothetical ORF ZYRO0C12606g similar to uniprot|P48361 Saccharomyces cerevisiae YGR097W ASK10 Component of the RNA polymerase II ZYRO0C12628g conserved hypothetical protein ZYRO0C12650g similar to uniprot|Q06109 Saccharomyces cerevisiae YPR116W Hypothetical ORF ZYRO0C12672g similar to uniprot|Q03018 Saccharomyces cerevisiae YGR098C ESP1 Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin inhibited by Pds1p ZYRO0C12694g similar to uniprot|P53038 Saccharomyces cerevisiae YGR099W TEL2 Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats required for telomere length regulation and telomere position effect ZYRO0C12716g similar to uniprot|Q06116 Saccharomyces cerevisiae YPR117W Hypothetical ORF ZYRO0C12738g highly similar to uniprot|P53258 Saccharomyces cerevisiae YGR100W MDR1 Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p Ypt31p and Sec4p involved in recycling of internalized proteins and regulation of Golgi secretory function ZYRO0C12760g similar to uniprot|P53259 Saccharomyces cerevisiae YGR101W PCP1 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology belongs to the rhomboid-GlpG superfamily of intramembrane peptidases ZYRO0C12782g similar to uniprot|P53260 Saccharomyces cerevisiae YGR102C Hypothetical ORF ZYRO0C12804g similar to uniprot|P53261 Saccharomyces cerevisiae YGR103W NOP7 Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis constituent of several different pre-ribosomal particles ZYRO0C12826g similar to uniprot|P32585 Saccharomyces cerevisiae YGR104C SRB5 subunit of RNA polymerase II holoenzyme/mediator complex ZYRO0C12848g similar to uniprot|P41806 Saccharomyces cerevisiae YGR105W VMA21 Protein involved in vacuolar H -ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex ZYRO0C12870g weakly similar to uniprot|P53262 Saccharomyces cerevisiae YGR106C Hypothetical ORF ZYRO0C12892g no similarity ZYRO0C12936g highly similar to uniprot|Q06489 Saccharomyces cerevisiae YPR118W Methylthioribose-1-phosphate isomerase catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway ZYRO0C12958g similar to uniprot|P32486 Saccharomyces cerevisiae YPR159W KRE6 Protein required for beta-1 6 glucan biosynthesis putative beta-glucan synthase appears functionally redundant with Skn1p ZYRO0C12980g similar to uniprot|P32486 Saccharomyces cerevisiae YPR159W KRE6 Protein required for beta-1 6 glucan biosynthesis putative beta-glucan synthase appears functionally redundant with Skn1p ZYRO0C13002g conserved hypothetical protein ZYRO0C13068g similar to uniprot|P40081 Saccharomyces cerevisiae YER134C Hypothetical ORF ZYRO0C13134g highly similar to uniprot|P32316 Saccharomyces cerevisiae YBL015W ACH1 Acetyl-coA hydrolase primarily localized to mitochondria required for acetate utilization and for diploid pseudohyphal growth ZYRO0C13156g highly similar to uniprot|P16892 Saccharomyces cerevisiae YBL016W FUS3 Mitogen-activated protein kinase involved in mating pheromone response activated by phoshporylation by Ste7p provides specificity during the mating vs. filamentous growth response by phosphorylating transcriptional and cytoplasmic targets ZYRO0C13178g similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments ZYRO0C13200g similar to uniprot|P38208 Saccharomyces cerevisiae YBL018C POP8 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends ZYRO0C13222g similar to uniprot|P38207 Saccharomyces cerevisiae YBL019W APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage homolog of human HAP1 and E. coli exoIII ZYRO0C13244g similar to uniprot|P38206 Saccharomyces cerevisiae YBL020W RFT1 Flippase essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane mutation is suppressed by expression human p53 protein ZYRO0C13266g no similarity ZYRO0C13288g similar to uniprot|P53164 Saccharomyces cerevisiae YGL067W NPY1 NADH diphosphatase (pyrophosphatase) hydrolyzes the pyrophosphate linkage in NADH and related nucleotides localizes to peroxisomes ZYRO0C13310g similar to uniprot|Q08959 Saccharomyces cerevisiae YPL206C Endoplasmic reticulum protein of unknown function ZYRO0C13332g some similarities with uniprot|P53165 Saccharomyces cerevisiae YGL066W SGF73 SaGa associated Factor 73kDa Probable 73KkDa Subunit of SAGA histone acetyltransferase complex ZYRO0C13354g similar to uniprot|P43636 Saccharomyces cerevisiae YGL065C ALG2 Mannosyltransferase mannosylates Man2GlcNAc2-PP-Dol to form Man3GlcNAc2-PP-Dol which is a precursor required for asparagine-linked protein glycosylation ZYRO0C13376g conserved hypothetical protein ZYRO0C13398g similar to uniprot|Q08960 Saccharomyces cerevisiae YPL207W Hypothetical ORF ZYRO0C13420g similar to uniprot|Q08961 Saccharomyces cerevisiae YPL208W Hypothetical ORF ZYRO0C13442g no similarity ZYRO0C13464g weakly similar to uniprot|P38241 Saccharomyces cerevisiae YBR065C ECM2 Pre-mRNA splicing factor facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome function may be regulated by Slu7p ZYRO0C13508g weakly similar to uniprot|P38082 Saccharomyces cerevisiae YBR066C ZYRO0C13552g similar to uniprot|P11353 YDR044W Saccharomyces cerevisiae HEM13 Coproporphyrinogen III oxidase ZYRO0C13574g highly similar to uniprot|Q04307 YDR045C Saccharomyces cerevisiae RPC11 RNA polymerase III subunit C11 ZYRO0C13596g similar to uniprot|P32893 Saccharomyces cerevisiae YGR166W KRE11 Protein involved in biosynthesis of cell wall beta-glucans subunit of the TRAPP (transport protein particle) complex which is involved in the late steps of endoplasmic reticulum to Golgi transport ZYRO0C13618g some similarities with uniprot|P17891 Saccharomyces cerevisiae YGR167W CLC1 Clathrin light chain ZYRO0C13640g weakly similar to uniprot|P53293 Saccharomyces cerevisiae YGR168C Hypothetical ORF ZYRO0C13662g weakly similar to uniprot|P47068 Saccharomyces cerevisiae YJL020C BBC1 Protein possibly involved in assembly of actin patches interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p localized predominantly to cortical actin patches ZYRO0C13684g similar to uniprot|P53294 Saccharomyces cerevisiae YGR169C PUS6 RNA:Psi-synthase and weakly similar to YOL066C uniprot|Q12362 Saccharomyces cerevisiae YOL066C RIB2 DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway; N-terminus has sequence similarity to RNA:pseudouridine synthases ZYRO0C13706g weakly similar to uniprot|P47065 Saccharomyces cerevisiae YJL023C PET130 Protein required for respiratory growth ZYRO0C13728g similar to uniprot|Q3E772 Saccharomyces cerevisiae YGR169C-A ZYRO0C13750g similar to uniprot|Q66RD8 Saccharomyces cerevisiae YDR299W BFR2 Essential protein possibly involved in secretion multicopy suppressor of sensitivity to Brefeldin A ZYRO0C13772g weakly similar to uniprot|P38768 Saccharomyces cerevisiae YHR034C PIH1 Protein of unresolved function may function in protein folding and/or rRNA processing interacts with a chaperone (Hsp82p) two chromatin remodeling factors (Rvb1p Rvb2p) and two rRNA processing factors (Rrp43p Nop58p) ZYRO0C13794g highly similar to uniprot|P32264 Saccharomyces cerevisiae YDR300C PRO1 Gamma-glutamyl kinase catalyzes the first step in proline biosynthesis and to YHR033W uniprot|P38690 Saccharomyces cerevisiae YHR033W Hypothetical ORF ZYRO0C13816g highly similar to uniprot|Q06632 Saccharomyces cerevisiae YDR301W CFT1 Functions in cleavage of 3'-ends of pre-mRNAs prior to polyadenylation 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160) Component of pre-mRNA cleavage factor II (CFII) 150-kDa protein associated with polyadenylation factor 1 (PF I) ZYRO0C13838g similar to uniprot|Q06636 Saccharomyces cerevisiae YDR302W GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate human PIG-Fp is a functional homolog; GPI11 ER membrane protein ZYRO0C13860g conserved hypothetical protein ZYRO0C13882g similar to uniprot|Q06639 Saccharomyces cerevisiae YDR303C RSC3 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p ZYRO0C13904g similar to uniprot|P35176 Saccharomyces cerevisiae YDR304C CPR5 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues transcriptionally induced in response to unfolded proteins in the ER ZYRO0C13926g similar to uniprot|P38782 Saccharomyces cerevisiae YHR058C MED6 RNA polymerase II transcriptional regulation mediator RNA polymerase II mediator subunit ZYRO0C13948g similar to uniprot|P38783 Saccharomyces cerevisiae YHR059W FYV4 Protein of unknown function required for survival upon exposure to K1 killer toxin ZYRO0C13970g similar to uniprot|P49775 Saccharomyces cerevisiae YDR305C ZYRO0C13992g similar to uniprot|Q06640 Saccharomyces cerevisiae YDR306C Hypothetical ORF ZYRO0C14036g similar to uniprot|Q06644 Saccharomyces cerevisiae YDR307W Hypothetical ORF ZYRO0C14058g highly similar to uniprot|P47822 Saccharomyces cerevisiae YDR308C SRB7 RNA polymerase II holoenzyme component ZYRO0C14080g similar to uniprot|P38784 Saccharomyces cerevisiae YHR060W VMA22 Protein involved in vacuolar H -ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex ZYRO0C14102g similar to uniprot|Q06648 Saccharomyces cerevisiae YDR309C GIC2 Protein of unknown function involved in initiation of budding and cellular polarization interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain ZYRO0C14124g similar to uniprot|P38786 Saccharomyces cerevisiae YHR062C RPP1 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends ZYRO0C14146g some similarities with uniprot|P46676 Saccharomyces cerevisiae YDR310C SUM1 Suppresor of mar1-1 (sir2) mutation nuclear protein involved in silencing ZYRO0C14168g similar to uniprot|P38787 Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase part of the pantothenic acid pathway structurally homologous to E. coli panE ZYRO0C14190g highly similar to gnl|GLV|CAGL0L10560g Candida glabrata CAGL0L10560g and similar to YHR064C uniprot|P38788 Saccharomyces cerevisiae YHR064C SSZ1 DnaK homolog interacts with Zuo1p (DnaJ homolog) to form a ribosome-associated complex (RAC) that is bound to the ribosome via the Zuo1p subunit Hsp70 Protein ZYRO0C14212g similar to uniprot|P32776 Saccharomyces cerevisiae YDR311W TFB1 Subunit of TFIIH and nucleotide excision repair factor 3 complexes required for nucleotide excision repair target for transcriptional activators ZYRO0C14234g highly similar to uniprot|Q75EW9 Ashbya gossypii AAL041C RRP3 ATP-dependent rRNA helicase RRP3 and similar to YHR065C uniprot|P38712 Saccharomyces cerevisiae YHR065C RRP3 Required for maturation of the 35S primary transcript of pre-rRNA and is required for cleavages leading to mature 18S RNA RRP3 is a DEAD box gene homologous to eIF- 4a which encodes an RNA-dependent ATPase possessing helicase activity which is not specific for RNA ZYRO0C14256g similar to uniprot|P38789 Saccharomyces cerevisiae YHR066W SSF1 putative involvement in mating homologous to Ssf2p ZYRO0C14278g similar to uniprot|Q6Q5S5 Saccharomyces cerevisiae YDR313C PIB1 RING-type ubiquitin ligase of the endosomal and vacuolar membranes binds phosphatidylinositol(3)-phosphate contains a FYVE finger domain ZYRO0C14300g similar to uniprot|Q06665 Saccharomyces cerevisiae YDR314C Hypothetical ORF ZYRO0C14322g similar to uniprot|P38790 Saccharomyces cerevisiae YHR067W HTD2 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis required for respiratory growth and for normal mitochondrial morphology ZYRO0C14344g similar to uniprot|Q06667 Saccharomyces cerevisiae YDR315C IPK1 Inositol 1 3 4 5 6-pentakisphosphate 2-kinase nuclear protein required for synthesis of 1 2 3 4 5 6-hexakisphosphate (phytate) which is integral to cell function has 2 motifs conserved in other fungi ipk1 gle1 double mutant is inviable ZYRO0C14366g highly similar to uniprot|P38791 Saccharomyces cerevisiae YHR068W DYS1 Deoxyhypusine synthase catalyzes formation of deoxyhypusine the first step in hypusine biosynthesis triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels tetrameric ZYRO0C14388g similar to uniprot|Q06668 Saccharomyces cerevisiae YDR316W OMS1 Protein integral to the mitochondrial membrane ZYRO0C14410g highly similar to uniprot|P38792 Saccharomyces cerevisiae YHR069C RRP4 Ribosomal RNA Processing 3->5 exoribonuclease Component of the exosome 3->5 exonuclease complex with Rrp41p Rrp42p Rrp43p and Dis3p (Rrp44p). ZYRO0C14432g similar to uniprot|P38793 Saccharomyces cerevisiae YHR070W TRM5 tRNA(m(1)G37)methyltransferase methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting highly conserved across Archaea Bacteria and Eukarya ZYRO0C14454g some similarities with uniprot|P38794 Saccharomyces cerevisiae YHR071W PCL5 Cyclin interacts with Pho85p cyclin-dependent kinase (Cdk) induced by Gcn4p at level of transcription specifically required for Gcn4p degradation may be sensor of cellular protein biosynthetic capacity ZYRO0C14476g similar to uniprot|P36088 Saccharomyces cerevisiae YKL069W Hypothetical ORF ZYRO0C14520g no similarity ZYRO0C14542g weakly similar to uniprot|P53133 Saccharomyces cerevisiae YGL117w ZYRO0C14564g similar to uniprot|P26309 Saccharomyces cerevisiae YGL116W CDC20 Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C) which is required for metaphase/anaphase transition directs ubiquitination of mitotic cyclins Pds1p and other anaphase inhibitors potential Cdc28p substrate ZYRO0C14608g highly similar to uniprot|P12904 Saccharomyces cerevisiae YGL115W SNF4 involved in release from glucose repression invertase expression and sporulation associates with Snf1p ZYRO0C14630g similar to uniprot|P53134 Saccharomyces cerevisiae YGL114W Putative member of the oligopeptide transporter (OPT) family of membrane transporters ZYRO0C14652g similar to uniprot|P38326 Saccharomyces cerevisiae YBR231C SWC5 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin ZYRO0C14674g similar to uniprot|P38151 Saccharomyces cerevisiae YBR233W ZYRO0C14696g similar to uniprot|P53135 Saccharomyces cerevisiae YGL113W SLD3 Protein that interacts with Cdc45p in initiation of DNA replication gene exhibits synthetic lethality with dpb11-1 ZYRO0C14718g highly similar to uniprot|P53040 Saccharomyces cerevisiae YGL112C TAF6 Subunit (60 kDa) of TFIID and SAGA complexes ZYRO0C14740g similar to uniprot|P69850 Saccharomyces cerevisiae YBR233W-A DAD3 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore ZYRO0C14762g highly similar to uniprot|P38328 Saccharomyces cerevisiae YBR234C ARC40 Essential subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches ZYRO0C14784g similar to uniprot|P53136 Saccharomyces cerevisiae YGL111W NSA1 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis ZYRO0C14806g similar to uniprot|P53137 Saccharomyces cerevisiae YGL110C CUE3 Protein of unknown function has a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination ZYRO0C14850g similar to uniprot|P32807 Saccharomyces cerevisiae YMR284W YKU70 Forms heterodimer with Yku80p known as Ku binds chromosome ends and is involved in maintaining normal telomere length and structure in addition to participating in the formation of silent chromatin at telomere-proximal genes ZYRO0C14872g similar to uniprot|Q03264 Saccharomyces cerevisiae YMR285C ZYRO0C14894g highly similar to uniprot|P20084 Saccharomyces cerevisiae YMR286W ZYRO0C14916g some similarities with uniprot|Q03208 Saccharomyces cerevisiae YML119W ZYRO0C14938g similar to uniprot|P39112 Saccharomyces cerevisiae YMR287C MSU1 RNase component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs ZYRO0C14960g highly similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae ZYRO0C14982g highly similar to uniprot|P53941 Saccharomyces cerevisiae YNL075W IMP4 Component of the SSU processome which is required for pre-18S rRNA processing interacts with Mpp10p member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs ZYRO0C15004g some similarities with uniprot|P34072 Saccharomyces cerevisiae YNL076W MKS1 Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation involved in retrograde (RTG) mitochondria-to-nucleus signaling ZYRO0C15026g weakly similar to uniprot|P16547 Saccharomyces cerevisiae YIL136W OM45 Protein of unknown function major constituent of the mitochondrial outer membrane located on the outer (cytosolic) face of the outer membrane ZYRO0C15048g similar to gnl|GLV|CAGL0J10296g Candida glabrata CAGL0J10296g and some similarites with YNL077W uniprot|P53940 Saccharomyces cerevisiae YNL077W APJ1 Putative chaperone of the HSP40 (DNAJ) family overexpression interferes with propagation of the [Psi ] prion ZYRO0C15070g similar to uniprot|P40462 Saccharomyces cerevisiae YIL137C RBF108 Hypothetical ORF ZYRO0C15092g weakly similar to uniprot|P53939 Saccharomyces cerevisiae YNL078W NIS1 Protein localized in the bud neck at G2/M phase physically interacts with septins possibly involved in a mitotic signaling network ZYRO0C15114g similar to uniprot|P40414 Saccharomyces cerevisiae YIL138C TPM2 Tropomyosin isoform 2 actin-binding protein that stabilizes actin filaments required with Tpm1 the main tropomyosin for the formation and stability of actin cables in vivo which direct polarized cell growth and the distribution of several organelles ZYRO0C15136g similar to gnl|GLV|YALI0D01936g Yarrowia lipolytica YALI0D01936g and some similarites with YNL080C uniprot|P53938 Saccharomyces cerevisiae ZYRO0C15158g similar to uniprot|P53937 Saccharomyces cerevisiae YNL081C SWS2 ZYRO0C15180g similar to uniprot|P14242 Saccharomyces cerevisiae YNL082W ZYRO0C15202g similar to uniprot|P38927 Saccharomyces cerevisiae YIL139C REV7 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage ZYRO0C15224g highly similar to gnl|GLV|KLLA0C11363g Kluyveromyces lactis KLLA0C11363g and similar to YNL083W uniprot|P48233 Saccharomyces cerevisiae YNL083W SAL1 Probable transporter member of the Ca2 -binding subfamily of the mitochondrial carrier family with two EF-hand motifs Pet9p and Sal1p have an overlapping function critical for viability polymorphic in different S. cerevisiae strains ZYRO0C15246g conserved hypothetical protein ZYRO0C15268g similar to uniprot|P38928 Saccharomyces cerevisiae YIL140W AXL2 Integral plasma membrane protein required for axial budding in haploid cells localizes to the incipient bud site and bud neck glycosylated by Pmt4p potential Cdc28p substrate ZYRO0C15290g similar to uniprot|P39013 Saccharomyces cerevisiae YNL084C END3 EH domain-containing protein involved in endocytosis actin cytoskeletal organization and cell wall morphogenesis forms a complex with Sla1p and Pan1p ZYRO0C15312g highly similar to uniprot|P39076 Saccharomyces cerevisiae YIL142W CCT2 Subunit beta of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo ZYRO0C15334g similar to uniprot|P40850 Saccharomyces cerevisiae YNL085W MKT1 Protein involved in propagation of M2 dsRNA satellite of L-A virus forms a complex with Pbp1p that is involved in posttranscriptional regulation of HO endonuclease ZYRO0C15356g similar to uniprot|P48439 Saccharomyces cerevisiae YOR085W OST3 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins Ost3p is important for N- glycosylation of a subset of proteins ZYRO0C15378g similar to uniprot|P48232 Saccharomyces cerevisiae YNL086W Hypothetical ORF ZYRO0C15400g similar to uniprot|Q12466 Saccharomyces cerevisiae YOR086C TCB1 Contains three calcium and lipid binding domains green fluorescent protein (GFP)-fusion protein localizes to the cell periphery C-terminal portion of Tcb1p Tcb2p and Tcb3p interact ZYRO0C15422g similar to uniprot|P06786 Saccharomyces cerevisiae YNL088W TOP2 Essential type II topoisomerase catalyzes topology changes in DNA via transient breakage and rejoining of phosphodiester bonds in the DNA backbone localizes to axial cores in meiosis ZYRO0C15466g highly similar to uniprot|P06781 Saccharomyces cerevisiae YNL090W RHO2 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity and in microtubule assembly ZYRO0C15488g some similarities with uniprot|P53935 Saccharomyces cerevisiae YNL091W NST1 Protein of unknown function mediates sensitivity to salt stress interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 ZYRO0C15510g similar to uniprot|Q12324 Saccharomyces cerevisiae YOR088W Calcium channel YVC1 ZYRO0C15532g similar to uniprot|P53934 Saccharomyces cerevisiae YNL092W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family ZYRO0C15554g highly similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C VPS21 Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization geranylgeranylated geranylgeranylation required for membrane association ZYRO0C15576g similar to uniprot|Q12511 Saccharomyces cerevisiae YOR090C PTC5 Mitochondrially localized type 2C protein phosphatase contains Mg2 /Mn2 -dependent casein phosphatase activity in vitro but in vivo substrates are unknown ZYRO0C15598g similar to uniprot|Q12000 Saccharomyces cerevisiae YOR091W RBF46 Hypothetical ORF ZYRO0C15620g similar to uniprot|P53933 Saccharomyces cerevisiae YNL094W APP1 Protein of unknown function interacts with Rvs161p and Rvs167p computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization ZYRO0C15642g similar to uniprot|P08425 Saccharomyces cerevisiae YPR047W ZYRO0C15664g similar to uniprot|Q12181 Saccharomyces cerevisiae YPR048W TAH18 Protein with a potential role in DNA replication displays synthetic lethal genetic interaction with the pol3-13 allele of POL3 which encodes DNA polymerase delta ZYRO0C15686g similar to uniprot|Q12527 Saccharomyces cerevisiae YPR049C ATG11 Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway also required for peroxisomal degradation (pexophagy) ZYRO0C15708g highly similar to gnl|GLV|CAGL0H08547g Candida glabrata CAGL0H08547g and similar to uniprot|Q03503 Saccharomyces cerevisiae YPR051W MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus ZYRO0C15730g highly similar to uniprot|P15873 Saccharomyces cerevisiae YBR088C POL30 Proliferating cell nuclear antigen (PCNA) functions as the sliding clamp for DNA polymerase delta may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair ZYRO0C15752g highly similar to uniprot|P11632 Saccharomyces cerevisiae YPR052C NHP6A High-mobility group non-histone chromatin protein functionally redundant with Nhp6Bp homologous to mammalian high mobility group proteins 1 and 2 acts to recruit transcription factor Rcs1p to certain promoters ZYRO0C15774g similar to uniprot|P32830 Saccharomyces cerevisiae YBR091C MRS5 Essential protein of the inner mitochondrial membrane peripherally localized component of the TIM22 complex which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins ZYRO0C15796g similar to uniprot|P38254 Saccharomyces cerevisiae YBR094W Hypothetical ORF ZYRO0C15818g similar to uniprot|P38255 Saccharomyces cerevisiae YBR095C RXT2 Hypothetical ORF ZYRO0C15840g similar to uniprot|P38256 Saccharomyces cerevisiae YBR096W Hypothetical ORF ZYRO0C15862g similar to uniprot|P41808 Saccharomyces cerevisiae YPR054W SMK1 Mitogen-activated protein kinase required for spore morphogenesis that is expressed as a middle sporulation-specific gene ZYRO0C15884g similar to uniprot|P22219 Saccharomyces cerevisiae YBR097W VPS15 Myristoylated Serine/threonine protein kinase involved in vacuolar protein sorting ZYRO0C15906g similar to uniprot|P32855 Saccharomyces cerevisiae YPR055W SEC8 Essential 121kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis ZYRO0C15928g similar to uniprot|P38257 Saccharomyces cerevisiae YBR098w ZYRO0C15950g similar to uniprot|P38260 Saccharomyces cerevisiae YBR101C FES1 Hsp70 (Ssa1p) nucleotide exchange factor cytosolic homolog of Sls1p which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum ZYRO0C15972g similar to uniprot|P38261 Saccharomyces cerevisiae YBR102C EXO84 Essential protein with dual roles in spliceosome assembly and exocytosis the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis ZYRO0C15994g similar to uniprot|P38262 Saccharomyces cerevisiae YBR103W SIF2 Sir4p-Interacting Factor 535 amino acid protein containing 4 WD-40 repeats and a nuclear localization signal ZYRO0C16016g highly similar to uniprot|Q12004 Saccharomyces cerevisiae YPR056W ZYRO0C16038g conserved hypothetical protein ZYRO0C16060g similar to uniprot|Q99177 Saccharomyces cerevisiae YPR057W BRR1 snRNP protein component of spliceosomal snRNPs required for pre-mRNA splicing and snRNP biogenesis in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed ZYRO0C16082g similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family ZYRO0C16104g highly similar to uniprot|P32178 Saccharomyces cerevisiae YPR060C ARO7 Chorismate mutase catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis ZYRO0C16126g similar to uniprot|Q12350 Saccharomyces cerevisiae YPR061C ZYRO0C16148g highly similar to uniprot|Q12178 Saccharomyces cerevisiae YPR062W FCY1 Cytosine deaminase involved in salvage pathways of pyrimidine metabolism ZYRO0C16170g similar to gnl|GLV|CAGL0D01540g Candida glabrata CAGL0D01540g and weakly similar to uniprot|Q12160 Saccharomyces cerevisiae YPR063C Hypothetical ORF ZYRO0C16192g similar to uniprot|P38263 Saccharomyces cerevisiae YBR105C VID24 also involved in vacuolar protein targeting peripheral vesicle membrane protein ZYRO0C16214g similar to uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes contains an HMG domain that is responsible for DNA bending activity ZYRO0C16236g highly similar to uniprot|P38264 Saccharomyces cerevisiae YBR106W PHO88 Probable membrane protein involved in phosphate transport ZYRO0C16258g similar to uniprot|Q99344 Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation GFP-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0C16280g similar to uniprot|Q12425 Saccharomyces cerevisiae YPR067W ISA2 Protein required for maturation of mitochondrial and cytosolic Fe/S proteins localizes to the mitochondrial intermembrane space overexpression of ISA2 suppresses grx5 mutations ZYRO0C16302g some similarities with uniprot|P38265 Saccharomyces cerevisiae YBR107C IML3 Protein with a role in kinetochore function localizes to the outer kinetochore in a Ctf19p-dependent manner interacts with Chl4p and Ctf19p ZYRO0C16324g some similarities with uniprot|P38266 Saccharomyces cerevisiae YBR108W ZYRO0C16346g highly similar to uniprot|P06787 Saccharomyces cerevisiae YBR109C CMD1 master regulator of calcium mediated signalling Calmodulin ZYRO0C16368g similar to uniprot|P16661 Saccharomyces cerevisiae YBR110W ALG1 Mannosyltransferase in the endoplasmic reticulum ZYRO0C16390g similar to uniprot|Q12214 Saccharomyces cerevisiae YPR068C ZYRO0C16412g highly similar to uniprot|Q12074 Saccharomyces cerevisiae YPR069C SPE3 biosynthesis of spermidine putrescine aminopropyltransferase (spermidine synthase) ZYRO0C16434g similar to uniprot|Q12321 Saccharomyces cerevisiae YPR070W MED1 transcriptional regulator ZYRO0C16478g similar to uniprot|Q01976 Saccharomyces cerevisiae YBR111C ZYRO0C16500g conserved hypothetical protein ZYRO0C16522g highly similar to uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co-repressor acts together with Tup1p also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters ZYRO0C16544g highly similar to uniprot|P31244 Saccharomyces cerevisiae YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) member of the SWI/SNF family ZYRO0C16566g highly similar to uniprot|P07702 Saccharomyces cerevisiae YBR115C LYS2 Alpha aminoadipate reductase ZYRO0C16588g highly similar to uniprot|Q12514 Saccharomyces cerevisiae YPR072W NOT5 Subunit of global transcriptional regulator ZYRO0C16610g highly similar to uniprot|P40347 Saccharomyces cerevisiae YPR073C LTP1 phosphatase ZYRO0C16632g similar to uniprot|P23254 Saccharomyces cerevisiae TKL1 and to YBR117C uniprot|P33315 Saccharomyces cerevisiae TKL2 Transketolase ZYRO0C16654g weakly similar to uniprot|Q6B149 Saccharomyces cerevisiae YPR075C OPY2 Protein of unknown function overproduction blocks cell cycle arrest in the presence of mating pheromone ZYRO0C16676g conserved hypothetical protein ZYRO0C16720g weakly similar to uniprot|Q06813 Saccharomyces cerevisiae YPR078C ZYRO0C16742g similar to uniprot|Q06815 Saccharomyces cerevisiae YPR079W MRL1 Membrane protein ZYRO0C16764g highly similar to uniprot|P02994 Saccharomyces cerevisiae YPR080W TEF1 functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes translational elongation factor EF-1 alpha ZYRO0C16786g similar to uniprot|P32605 Saccharomyces cerevisiae YBR119W MUD1 U1 snRNP A protein homolog of human U1-A involved in nuclear mRNA splicing ZYRO0C16808g highly similar to gnl|GLV|KLLA0B08954g Kluyveromyces lactis KLLA0B08954g and similar to YBR120C uniprot|P07253 Saccharomyces cerevisiae YBR120C CBP6 Translational activator of COB mRNA ZYRO0C16830g highly similar to uniprot|P38088 Saccharomyces cerevisiae YBR121C GRS1 glycyl-tRNA synthase ZYRO0C16852g highly similar to uniprot|Q06819 Saccharomyces cerevisiae YPR082C DIB1 component of the U4/U6aU5 tri-snRNP ZYRO0C16874g similar to uniprot|P36531 Saccharomyces cerevisiae YBR122C MRPL36 Mitochondrial ribosomal protein of the large subunit ZYRO0C16896g similar to uniprot|P32367 Saccharomyces cerevisiae YBR123C, subunit of the RNA polymerase III transcription initiation factor complex (TFIIIC) ZYRO0C16918g similar to uniprot|P38089 Saccharomyces cerevisiae YBR125C PTC4 Cytoplasmic type 2C protein phosphatase identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity ZYRO0C16940g uniprot|Q96WK6 Zygosaccharomyces rouxii TPS1 Alpha, alpha- trehalose-phosphate synthase ZYRO0C16962g similar to uniprot|Q06820 Saccharomyces cerevisiae YPR083W MDM36 Mitochondrial Distribution and Morphology ZYRO0C16984g highly similar to uniprot|P16140 Saccharomyces cerevisiae YBR127C VMA2 Vacuolar H ATPase regulatory subunit ZYRO0C17006g similar to uniprot|P38270 Saccharomyces cerevisiae YBR128C ATG14 Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p Vps15p and Vps30p) required for organization of a pre-autophagosomal structure ATG14 transcription is activated by Gln3p during nitrogen starvation ZYRO0C17028g similar to uniprot|Q06821 Saccharomyces cerevisiae YPR084W Hypothetical ORF ZYRO0C17050g similar to gnl|GLV|KLLA0D09086g Kluyveromyces lactis KLLA0D09086g and weakly similar to YPR085C uniprot|Q06822 Saccharomyces cerevisiae YPR085C Protein required for cell viability ZYRO0C17072g similar to uniprot|P38271 Saccharomyces cerevisiae YBR129C OPY1 Protein of unknown function overproduction blocks cell cycle arrest in the presence of mating pheromone ZYRO0C17094g weakly similar to uniprot|P38272 Saccharomyces cerevisiae YBR130C SHE3 Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud also required for cortical ER inheritance ZYRO0C17116g highly similar to uniprot|P29055 Saccharomyces cerevisiae YPR086W SUA7 Transcription factor TFIIB a general transcription factor required for transcription initiation and start site selection by RNA polymerase II ZYRO0C17138g highly similar to uniprot|P20424 Saccharomyces cerevisiae YPR088C SRP54 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) contains the signal sequence-binding activity of SRP interacts with the SRP RNA and mediates binding of SRP to signal receptor contains GTPase domain ZYRO0C17160g similar to uniprot|P38273 Saccharomyces cerevisiae YBR131W CCZ1 Protein involved in vacuolar assembly ZYRO0C17182g similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 Plasma membrane carnitine transporter expression is down-regulated by osmotic stress also functions as a low-affinity amino acid permease ZYRO0C17204g similar to uniprot|Q86ZS6 Saccharomyces cerevisiae YPR089W Hypothetical ORF ZYRO0C17226g similar to uniprot|P38274 Saccharomyces cerevisiae YBR133C HSL7 Protein arginine N-methyltransferase, bud neck localization ZYRO0C17248g highly similar to uniprot|P20486 Saccharomyces cerevisiae YBR135W CKS1 Subunit of the Cdc28 protein kinase required for mitotic proteolysis may also be involved in the proteolysis of the G1 cyclins ZYRO0C17270g similar to uniprot|P38111 Saccharomyces cerevisiae YBR136W MEC1 Central regulator of the Mec1p/Tel1p signaling network; required for mitotic growth, DNA repair and mitotic recombination, regulates phosphorylation of Rad53p, required for dmc1 arrest and meiotic recombination; similar to phosphatidylinositol (PI)3- kinases required for DNA damage induced checkpoint responses in G1, S/M, intra S, and G2/M in mitosis ZYRO0C17292g similar to uniprot|Q06833 Saccharomyces cerevisiae YPR091C Hypothetical ORF ZYRO0C17380g some similarities with uniprot|P53249 Saccharomyces cerevisiae YGR079W Hypothetical ORF ZYRO0C17402g similar to uniprot|P53250 Saccharomyces cerevisiae YGR080W TWF1 Twinfilin A member of a conserved family of actin monomer sequestering proteins comprised almost entirely of two tandem repeats each having sequence homology with cofilin (Cof1p) ZYRO0C17424g weakly similar to uniprot|Q06834 Saccharomyces cerevisiae YPR093C ASR1 Protein involved in a putative alcohol-responsive signaling pathway accumulates in the nucleus under alcohol stress contains a Ring/PHD finger domain ZYRO0C17446g highly similar to uniprot|Q06835 Saccharomyces cerevisiae YPR094W RDS3 essential zinc finger protein ZYRO0C17468g some similarities with uniprot|Q06836 Saccharomyces cerevisiae YPR095C SYT1 Suppressor of Ypt3 ZYRO0C17490g similar to uniprot|Q06839 Saccharomyces cerevisiae YPR097W mitochondrial protein ZYRO0C17512g similar to uniprot|P53251 Saccharomyces cerevisiae YGR081C ZYRO0C17534g highly similar to uniprot|P35180 Saccharomyces cerevisiae YGR082W TOM20 Translocase of Outer Mitochondrial membrane ZYRO0C17556g similar to uniprot|Q06089 Saccharomyces cerevisiae YPR098C Hypothetical ORF ZYRO0C17578g highly similar to uniprot|Q06090 Saccharomyces cerevisiae YPR100W MRPL51 Mitochondrial ribosomal protein of the large subunit ZYRO0C17600g similar to uniprot|P12754 Saccharomyces cerevisiae YGR083C GCD2 Delta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression ZYRO0C17622g similar to uniprot|P12686 Saccharomyces cerevisiae YGR084C MRP13 Mitochondrial ribosomal protein of the small subunit ZYRO0C17644g similar to uniprot|Q06091 Saccharomyces cerevisiae YPR101W SNT309 Component of a protein complex associated with the splicing factor Prp19p essential for mRNA splicing ZYRO0C17666g highly similar to uniprot|P06380 Saccharomyces cerevisiae RPL11A and to uniprot|P06380 Saccharomyces cerevisiae YGR085C RPL11B component of the large (60S) ribosomal subunit ZYRO0C17688g highly similar to uniprot|P30656 Saccharomyces cerevisiae YPR103W PRE2 20S proteasome beta-type subunit ZYRO0C17710g some similarities with uniprot|P39521 Saccharomyces cerevisiae YPR104C ZYRO0C17732g similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex ZYRO0C17754g highly similar to uniprot|P53252 Saccharomyces cerevisiae YGR086C PIL1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Lsp1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p ZYRO0C17776g highly similar to uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor contains five zinc fingers required for pre-mRNA 3'-end processing and polyadenylation ZYRO0C17798g highly similar to uniprot|Q75A91 Ashbya gossypii ADR027W ADR027Wp and similar to YPR108W uniprot|Q06103 Saccharomyces cerevisiae ZYRO0C17820g similar to uniprot|P06115 Saccharomyces cerevisiae YGR088W CTT1 Cytosolic catalase T has a role in protection from oxidative damage by hydrogen peroxide ZYRO0C17842g similar to uniprot|P25358 Saccharomyces cerevisiae YCR034W FEN1 Fatty acid elongase involved in sphingolipid biosynthesis acts on fatty acids of up to 24 carbons in length mutations have regulatory effects on 1 3-beta-glucan synthase vacuolar ATPase and the secretory pathway ZYRO0C17864g similar to uniprot|P25359 Saccharomyces cerevisiae YCR035C RRP43 Ribosomal RNA Processing ZYRO0C17886g similar to uniprot|P25332 Saccharomyces cerevisiae YCR036W RBK1 Putative ribokinase ZYRO0C17908g similar to uniprot|P39538 Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins ZYRO0C17930g similar to uniprot|P25360 Saccharomyces cerevisiae YCR037C PHO87 Low-affinity inorganic phosphate (Pi) transporter involved in activation of PHO pathway expression is independent of Pi concentration and Pho4p activity contains 12 membrane-spanning segments and uniprot|P39535 Saccharomyces cerevisiae YJL198W PHO90 ZYRO0C17974g highly similar to uniprot|P39533 Saccharomyces cerevisiae YJL200C Hypothetical ORF ZYRO0C17996g similar to gnl|GLV|KLLA0C03410g Kluyveromyces lactis KLLA0C03410g and weakly similar to YCR038C uniprot|P25300 Saccharomyces cerevisiae YCR038C BUD5 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types ZYRO0C18018g similar to uniprot|P32525 Saccharomyces cerevisiae YJL201W ECM25 Non-essential protein of unknown function promoter contains a consensus binding sequence for factor Abf1p ZYRO0C18062g similar to uniprot|P32524 Saccharomyces cerevisiae YJL203W PRP21 Subunit of the SF3a splicing factor complex required for spliceosome assembly ZYRO0C18084g similar to uniprot|P39531 Saccharomyces cerevisiae YJL204C RCY1 ReCYcling 1 ZYRO0C18150g some similarities with uniprot|P39529 Saccharomyces cerevisiae YJL206C ZYRO0C18194g similar to uniprot|P39526 Saccharomyces cerevisiae YJL207C Hypothetical ORF ZYRO0C18216g similar to uniprot|P08466 Saccharomyces cerevisiae YJL208C NUC1 Major mitochondrial nuclease has RNAse and DNA endo- and exonucleolytic activities has a role in mitochondrial recombination ZYRO0C18238g similar to uniprot|P07252 Saccharomyces cerevisiae YJL209W CBP1 Protein required for COB mRNA stability or 5' processing required for translation of COB mRNAs ZYRO0C18260g similar to uniprot|P32800 Saccharomyces cerevisiae YJL210W PEX2 RING-finger peroxin peroxisomal membrane protein with a C-terminal zinc-binding RING domain forms putative translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import ZYRO0C18282g conserved hypothetical protein ZYRO0C18304g similar to uniprot|P87332 Saccharomyces cerevisiae YLR348C DIC1 Mitochondrial dicarboxylate carrier integral membrane protein catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane transports cytoplasmic dicarboxylates into the mitochondrial matrix ZYRO0C18326g some similarities with uniprot|P25042 Saccharomyces cerevisiae YPR065W ZYRO0C18348g some similarities with uniprot|Q06724 Saccharomyces cerevisiae YCR097W ZYRO0C18392g similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF ZYRO0C18414g conserved hypothetical protein ZYRO0C18436g similar to uniprot|P40037 Saccharomyces cerevisiae YER057C ZYRO0C18458g conserved hypothetical protein ZYRO0C18480g weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine ZYRO0C18502g similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline-specific permease ZYRO0C18524g similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions ZYRO0C18546g similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W ZYRO0C18568g similar to uniprot|O59822 Schizosaccharomyces pombe SPCC1840 SPCC965.02 protein and weakly similar to YJL212C uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family ZYRO0C18590g weakly similar to uniprot|P53053 Saccharomyces cerevisiae YGL263W COS12 Protein of unknown function member of a family of conserved often subtelomerically- encoded proteins ZYRO0C18612g some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments ZYRO0D00154g weakly similar to uniprot|P43542 Saccharomyces cerevisiae YFL062W COS4 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins ZYRO0D00176g no similarity ZYRO0D00220g no similarity ZYRO0D00242g weakly similar to uniprot|P53822 Saccharomyces cerevisiae YNL336W COS1 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins ZYRO0D00264g no similarity ZYRO0D00286g similar to uniprot|O43081 Schizosaccharomyces pombe SPBC947 SPBC947.06c protein and weakly similar to YHR048W uniprot|P38776 Saccharomyces cerevisiae YHR048W Hypothetical ORF ZYRO0D00330g highly similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family ZYRO0D00352g weakly similar to uniprot|P43542 Saccharomyces cerevisiae YFL062W COS4 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins ZYRO0D00396g highly similar to uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid dihydroorotate dehydrogenase ZYRO0D00418g similar to uniprot|P40582 Saccharomyces cerevisiae YIR038C GTT1 ER associated glutathione S-transferase capable of homodimerization expression induced during the diauxic shift and throughout stationary phase functional overlap with Gtt2p Grx1p and Grx2p ZYRO0D00440g conserved hypothetical protein ZYRO0D00462g no similarity ZYRO0D00484g similar to uniprot|P36102 Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes ZYRO0D00506g similar to uniprot|P40579 Saccharomyces cerevisiae YIR035C Hypothetical ORF ZYRO0D00528g similar to uniprot|P15700 Saccharomyces cerevisiae YKL024C URA6 ZYRO0D00550g no similarity ZYRO0D00572g similar to uniprot|P09798 Saccharomyces cerevisiae YKL022C CDC16 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition required for sporulation ZYRO0D00594g highly similar to uniprot|P38998 Saccharomyces cerevisiae YIR034C LYS1 Saccharopine dehydrogenase (NAD L-lysine-forming) catalyzes the conversion of saccharopine to L-lysine which is the final step in the lysine biosynthesis pathway ZYRO0D00616g similar to uniprot|P20484 Saccharomyces cerevisiae YKL021C MAK11 Protein essential for cell growth and replication of M dsRNA virus contains four beta-transducin repeats ZYRO0D00638g similar to uniprot|P40578 MGA2 and to YKL020C uniprot|P35210 SPT23, Saccharomyces cerevisiae ER membrane proteins involved in regulation of OLE1 transcription ZYRO0D00660g similar to uniprot|P29703 Saccharomyces cerevisiae YKL019W RAM2 CAAX farnesyltransferase alpha subunit ZYRO0D00682g similar to uniprot|Q02256 Saccharomyces cerevisiae YIR026C YVH1 nitrogen starvation-induced protein phosphatase ZYRO0D00704g weakly similar to uniprot|P40577 Saccharomyces cerevisiae YIR025w MND2 Subunit of the anaphase-promoting complex (APC); needed for meiotic nuclear division ZYRO0D00726g similar to uniprot|Q3E7A7 Saccharomyces cerevisiae YKL018C-A ZYRO0D00748g highly similar to uniprot|P36104 Saccharomyces cerevisiae YKL018W SWD2 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres ZYRO0D00770g similar to uniprot|P34243 Saccharomyces cerevisiae YKL017C HCS1 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis contains single-stranded DNA stimulated ATPase and dATPase activities replication protein A stimulates helicase and ATPase activities ZYRO0D00814g similar to uniprot|P32349 Saccharomyces cerevisiae YPR190C RPC82 RNA polymerase III subunit C82 ZYRO0D00836g similar to uniprot|P17883 Saccharomyces cerevisiae YPR189W SKI3 dsRNA virus protection family member contains 8 copies of the tetratricopeptide (TPR) domain ZYRO0D00858g similar to uniprot|Q06580 Saccharomyces cerevisiae YPR188C MLC2 Regulatory light chain for the type II myosin Myo1p binds to an IQ motif of Myo1p localization to the bud neck depends on Myo1p involved in the disassembly of the Myo1p ring ZYRO0D00880g highly similar to uniprot|P20435 Saccharomyces cerevisiae YPR187W RPO26 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit ZYRO0D00902g similar to uniprot|P39933 Saccharomyces cerevisiae YPR186C PZF1 Transcription factor IIIA (TFIIIA) with putative Zn-fingers ZYRO0D00924g similar to uniprot|Q06628 Saccharomyces cerevisiae YPR185W ATG13 Phosphorylated protein that interacts with Vac8p required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy ZYRO0D00946g highly similar to uniprot|O93808 Saccharomyces cerevisiae YPR184W GDB1 Glycogen debranching enzyme containing glucanotranferase and alpha-1 6-amyloglucosidase activities required for glycogen degradation ZYRO0D00968g highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man required for glycosyl phosphatidylinositol membrane anchoring O mannosylation and protein glycosylation ZYRO0D00990g similar to uniprot|P54999 Saccharomyces cerevisiae YPR182W SMX3 Sm or Sm-like snRNP protein ZYRO0D01012g similar to uniprot|P41733 Saccharomyces cerevisiae YLR459W GAB1 GPI transamidase subunit involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins may have a role in recognition of the attachment signal or of the lipid portion of GPI ZYRO0D01056g highly similar to uniprot|P15303 Saccharomyces cerevisiae YPR181C SEC23 cytoplasmic GTPase-activating protein ZYRO0D01078g similar to uniprot|Q06624 Saccharomyces cerevisiae YPR180W AOS1 Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability ZYRO0D01100g similar to uniprot|Q06623 Saccharomyces cerevisiae YPR179C ZYRO0D01122g similar to uniprot|P20053 Saccharomyces cerevisiae YPR178W PRP4 Splicing factor component of the U4/U6-U5 snRNP complex ZYRO0D01144g highly similar to uniprot|P20133 Saccharomyces cerevisiae YPR176C BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p ZYRO0D01166g similar to uniprot|P24482 Saccharomyces cerevisiae YPR175W DPB2 Second largest subunit of DNA polymerase II (DNA polymerase epsilon) required for normal yeast chromosomal replication expression peaks at the G1/S phase boundary potential Cdc28p substrate ZYRO0D01188g weakly similar to uniprot|P52919 Saccharomyces cerevisiae YLR457C NBP1 Component of the mitotic apparatus containing a coiled-coil domain essential for the G2/M transition ZYRO0D01210g highly similar to uniprot|P52917 Saccharomyces cerevisiae YPR173C VPS4 Defective in vacuolar protein sorting homologous to mouse SKD1 and to human hVPS4 AAA-type ATPase ZYRO0D01232g similar to uniprot|Q06608 Saccharomyces cerevisiae YPR172W Protein of unknown function transcriptionally activated by Yrm1p along with genes involved in multidrug resistance ZYRO0D01254g similar to uniprot|Q06188 Saccharomyces cerevisiae YLR455W Hypothetical ORF ZYRO0D01276g weakly similar to uniprot|Q06604 Saccharomyces cerevisiae YPR171W BSP1 Adapter that links synaptojanins Inp2p and Inp53p to the cortical actin cytoskeleton ZYRO0D01298g similar to uniprot|P0C5R7 Saccharomyces cerevisiae YPR169W-A Identified by fungal homology and RT-PCR ZYRO0D01364g similar to uniprot|Q06214 Saccharomyces cerevisiae YPR169W JIP5 Nucleolar protein of unknown function exhibits a physical interaction with Bre1p ZYRO0D01386g highly similar to uniprot|Q06213 Saccharomyces cerevisiae YPR168W NUT2 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription ZYRO0D01408g similar to uniprot|P18408 Saccharomyces cerevisiae YPR167C MET16 3'-phosphoadenylsulfate reductase reduces 3'-phosphoadenylyl sulfate to adenosine-3' 5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate involved in sulfate assimilation and methionine metabolism ZYRO0D01430g highly similar to uniprot|P10663 Saccharomyces cerevisiae YPR166C MRP2 Mitochondrial ribosomal protein of the small subunit ZYRO0D01452g similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins involved in establishment of cell polarity regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1 3-beta-glucan synthase (Fks1p and Gsc2p) ZYRO0D01474g highly similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins involved in establishment of cell polarity regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1 3-beta-glucan synthase (Fks1p and Gsc2p) ZYRO0D01496g weakly similar to uniprot|Q06211 Saccharomyces cerevisiae YPR164W MMS1 Protein likely involved in protection against replication-dependent DNA damage mutants are sensitive to methyl methanesulfonate (MMS) implicated in regulation of Ty1 transposition ZYRO0D01518g similar to uniprot|Q06179 Saccharomyces cerevisiae YLR454W FMP27 The authentic non-tagged protein was localized to the mitochondria ZYRO0D01540g similar to uniprot|P34167 Saccharomyces cerevisiae YPR163C TIF3 Suppressor of translation mutants Translation initiation factor eIF-4B ZYRO0D01562g similar to uniprot|P54791 Saccharomyces cerevisiae YPR162C ORC4 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing ZYRO0D01584g some similarities with uniprot|P23293 Saccharomyces cerevisiae YPR161C SGV1 CDC28/cdc2 related protein kinase ZYRO0D01606g similar to uniprot|P11972 Saccharomyces cerevisiae YLR452C SST2 Protein involved in desensitization to alpha-factor pheromone member of the RGS (regulator of G-protein signalling) family GTPase-activating protein ZYRO0D01628g highly similar to uniprot|P32481 Saccharomyces cerevisiae YER025W GCD11 Gamma subunit of the translation initiation factor eIF2 involved in the identification of the start codon binds GTP when forming the ternary complex with GTP and tRNAi-Met ZYRO0D01650g similar to uniprot|P08638 Saccharomyces cerevisiae YLR451W LEU3 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation positively regulated by alpha-isopropylmalate an intermediate in leucine biosynthesis ZYRO0D01672g similar to uniprot|P47159 Saccharomyces cerevisiae YJR124C Hypothetical ORF ZYRO0D01694g similar to uniprot|P40017 YER024W Saccharomyces cerevisiae YAT2 Carnitine acetyltransferase ZYRO0D01716g highly similar to uniprot|P26783 Saccharomyces cerevisiae YJR123W ZYRO0D01738g similar to uniprot|P47158 Saccharomyces cerevisiae YJR122W CAF17 Mitochondrial protein that interacts with Ccr4p in the two-hybrid system 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins ZYRO0D01760g uniprot|Q76FP6 Zygosaccharomyces rouxii ZrATP2 Mitochondrial ATPase beta-subunit ZYRO0D01782g similar to uniprot|P32263 Saccharomyces cerevisiae YER023W PRO3 Delta 1-pyrroline-5-carboxylate reductase catalyzes the last step in proline biosynthesis ZYRO0D01804g similar to uniprot|P47156 Saccharomyces cerevisiae YJR119C Hypothetical ORF ZYRO0D01826g similar to uniprot|P47155 Saccharomyces cerevisiae YJR118C ILM1 Protein of unknown function ZYRO0D01848g similar to uniprot|P32569 Saccharomyces cerevisiae YER022W SRB4 subunit of RNA polymerase II holoenzyme/mediator complex ZYRO0D01870g similar to uniprot|P40016 Saccharomyces cerevisiae YER021W ZYRO0D01892g highly similar to uniprot|P47154 Saccharomyces cerevisiae YJR117W STE24 Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing contains multiple transmembrane spans ZYRO0D01914g similar to uniprot|P47153 Saccharomyces cerevisiae YJR116W Hypothetical ORF ZYRO0D01936g similar to uniprot|P47143 Saccharomyces cerevisiae YJR105W ADO1 adenosine kinase ZYRO0D01958g similar to uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Non-essential protein of unknown function ZYRO0D01980g similar to uniprot|P47145 Saccharomyces cerevisiae YJR107W Hypothetical ORF ZYRO0D02002g similar to uniprot|P10823 Saccharomyces cerevisiae YER020W GPA2 Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p has signaling role in response to nutrients green fluorescent protein (GFP)-fusion protein localizes to the cell periphery ZYRO0D02024g similar to uniprot|P36147 Saccharomyces cerevisiae YKR065C FMP18 The authentic non-tagged protein was localized to the mitochondria ZYRO0D02046g weakly similar to uniprot|P14359 Saccharomyces cerevisiae YJL151C SNA3 Integral membrane protein localized to vacuolar intralumenal vesicles computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting ZYRO0D02068g similar to uniprot|P47005 Saccharomyces cerevisiae YJL149W ZYRO0D02090g similar to uniprot|P36023 Saccharomyces cerevisiae YKR064W Hypothetical ORF ZYRO0D02112g similar to uniprot|P36146 Saccharomyces cerevisiae YKR063C LAS1 Essential nuclear protein possibly involved in bud formation and morphogenesis mutants require the SSD1-v allele for viability ZYRO0D02178g similar to gnl|GLV|KLLA0A05973g Kluyveromyces lactis KLLA0A05973g and some similarites with YJL148W uniprot|P47006 Saccharomyces cerevisiae YJL148W RPA34 RNA polymerase I subunit A34.5 ZYRO0D02200g similar to uniprot|P36145 Saccharomyces cerevisiae YKR062W TFA2 TFIIE small subunit involved in RNA polymerase II transcription initiation ZYRO0D02222g similar to uniprot|P47007 Saccharomyces cerevisiae YJL147C Hypothetical ORF ZYRO0D02244g weakly similar to uniprot|P46958 Saccharomyces cerevisiae YJL146W IDS2 Protein involved in modulation of Ime2p activity during meiosis appears to act indirectly to promote Ime2p-mediated late meiotic functions found in growing cells and degraded during sporulation ZYRO0D02266g similar to uniprot|P47008 Saccharomyces cerevisiae YJL145W SFH5 putative phosphatidylinositol transfer protein ZYRO0D02288g highly similar to uniprot|P32451 Saccharomyces cerevisiae YGR286C BIO2 Biotin synthase catalyzes the conversion of dethiobiotin to biotin which is the last step of the biotin biosynthesis pathway complements E. coli bioB mutant ZYRO0D02310g no similarity ZYRO0D02332g similar to uniprot|P40480 Saccharomyces cerevisiae YIL112W HOS4 Subunit of the Set3 complex which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity potential Cdc28p substrate ZYRO0D02354g highly similar to uniprot|P00424 Saccharomyces cerevisiae YNL052W COX5A ZYRO0D02376g similar to uniprot|P40481 Saccharomyces cerevisiae YIL110W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family ZYRO0D02398g similar to uniprot|P53951 Saccharomyces cerevisiae YNL051W COG5 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ZYRO0D02420g similar to uniprot|P53952 Saccharomyces cerevisiae YNL050C ZYRO0D02442g similar to uniprot|P40482 Saccharomyces cerevisiae YIL109C SEC24 The Sec23p-Sec24p complex is one of three cytoplamic COPII factors involved in ER to Golgi transport vesicle coat component ZYRO0D02464g similar to uniprot|P40483 Saccharomyces cerevisiae YIL108W Hypothetical ORF ZYRO0D02486g similar to uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate has negligible fructose-2 6-bisphosphatase activity transcriptional regulation involves protein kinase A ZYRO0D02508g highly similar to uniprot|P40484 Saccharomyces cerevisiae YIL106W MOB1 Mps One Binder (putative) transcriptional regulator involved in mitosis ZYRO0D02530g similar to uniprot|P53954 Saccharomyces cerevisiae YNL048W ALG11 Alpha-1 2-mannosyltransferase catalyzes addition of the terminal alpha 1 2-Man to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER ZYRO0D02552g similar to uniprot|P40485 Saccharomyces cerevisiae YIL105C SLM1 Phosphoinositide PI4 5P(2) binding protein forms a complex with Slm2p acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress phosphorylated by the Tor2p-containing complex TORC2 ZYRO0D02574g similar to uniprot|Q10740 Saccharomyces cerevisiae YNL045W Similar to human LTA4 hydrolase but in vivo substrates not yet defined. ZYRO0D02596g similar to uniprot|P53633 Saccharomyces cerevisiae YNL044W YIP3 Interacts with YPT proteins ZYRO0D02618g weakly similar to uniprot|P53958 Saccharomyces cerevisiae YNL042W BOP3 Protein of unknown function potential Cdc28p substrate overproduction suppresses a pam1 slv3 double null mutation ZYRO0D02640g similar to uniprot|P40486 Saccharomyces cerevisiae YIL104C SHQ1 Essential nuclear protein required for accumulation of box H/ACA snoRNAs and for rRNA processing interacts with Naf1p ZYRO0D02662g highly similar to uniprot|P40487 Saccharomyces cerevisiae YIL103W DPH1 Protein required along with Dph2p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph2p and Kti11p ZYRO0D02684g similar to uniprot|P53959 Saccharomyces cerevisiae YNL041C COG6 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ZYRO0D02728g weakly similar to uniprot|P40489 Saccharomyces cerevisiae YIL101C ZYRO0D02750g similar to uniprot|P53615 Saccharomyces cerevisiae YNL036W NCE103 Carbonic anhydrase poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions involved in non-classical protein export pathway ZYRO0D02772g similar to uniprot|P08019 Saccharomyces cerevisiae YIL099W SGA1 Intracellular sporulation-specific glucoamylase involved in glycogen degradation induced during starvation of a/a diploids late in sporulation but dispensable for sporulation ZYRO0D02794g similar to uniprot|P40491 Saccharomyces cerevisiae YIL098C FMC1 Mitochondrial matrix protein required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase ZYRO0D02816g similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance ZYRO0D02838g similar to uniprot|P28834 Saccharomyces cerevisiae YNL037C IDH1 Subunit of mitochondrial NAD()-dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle ZYRO0D02860g similar to uniprot|P40492 Saccharomyces cerevisiae YIL097W FYV10 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains CTLH domain ZYRO0D02882g similar to uniprot|P40493 Saccharomyces cerevisiae YIL096C Hypothetical ORF ZYRO0D02904g similar to uniprot|P53961 Saccharomyces cerevisiae YNL038W GPI15 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-H protein ZYRO0D02926g weakly similar to uniprot|P46678 Saccharomyces cerevisiae YNL039W BDP1 Essential subunit of RNA polymerase III transcription factor (TFIIIB) which is involved in transcription of genes encoding tRNAs 5S rRNA U6 snRNA and other small RNAs ZYRO0D02948g highly similar to uniprot|P39515 Saccharomyces cerevisiae YJL143W TIM17 Mitochondrial inner membrane protein involved in protein import 16.5 kDa inner membrane protein required for import of mitochondrial precursor proteins ZYRO0D02970g similar to uniprot|P14680 Saccharomyces cerevisiae YJL141C YAK1 Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal ZYRO0D02992g similar to uniprot|P20433 Saccharomyces cerevisiae YJL140W RPB4 RNA polymerase II subunit B32 forms two subunit dissociable complex with Rpb7p dispensable under some environmental conditions involved in export of mRNA to cytoplasm under stress conditions ZYRO0D03014g similar to uniprot|P33550 Saccharomyces cerevisiae YKR061W KTR2 Mannosyltransferase involved in N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family ZYRO0D03036g similar to uniprot|P36144 Saccharomyces cerevisiae YKR060W UTP30 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data ZYRO0D03058g highly similar to uniprot|P10081 Saccharomyces cerevisiae YKR059W TIF1 translation initiation factor eIF4A ZYRO0D03080g weakly similar to uniprot|P47011 Saccharomyces cerevisiae YJL137C ZYRO0D03102g highly similar to uniprot|P05760 Saccharomyces cerevisiae YJL136C ZYRO0D03124g similar to uniprot|P33753 Saccharomyces cerevisiae YKR056W TRM2 tRNA methyltransferase 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation previously thought to be an endo-exonuclease ZYRO0D03146g similar to uniprot|Q00246 Saccharomyces cerevisiae YKR055W RHO4 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins likely to be involved in the establishment of cell polarity ZYRO0D03168g similar to uniprot|P36022 Saccharomyces cerevisiae YKR054C DYN1 Cytoplasmic heavy chain dynein microtubule motor protein required for anaphase spindle elongation involved in spindle assembly chromosome movement and spindle orientation during cell division targeted to microtubule tips by Pac1p ZYRO0D03190g similar to uniprot|P47013 Saccharomyces cerevisiae YJL134W LCB3 Long-chain base-1-phosphate phosphatase regulates ceramide and long-chain base phosphates levels involved in incorporation of exogenous long chain bases in sphingolipids ZYRO0D03212g similar to uniprot|P23500 Saccharomyces cerevisiae YKR052C MRS4 Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron ZYRO0D03234g similar to uniprot|P36142 Saccharomyces cerevisiae YKR051W Hypothetical ORF ZYRO0D03256g similar to uniprot|P47014 Saccharomyces cerevisiae YJL132W Hypothetical ORF ZYRO0D03278g similar to uniprot|P47015 Saccharomyces cerevisiae YJL131C Hypothetical ORF ZYRO0D03300g similar to uniprot|P07259 Saccharomyces cerevisiae YJL130C URA2 Multifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase) that catalyzes the two first reactions of the pyrimidine pathway; carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase ZYRO0D03322g some similarities with uniprot|P12685 Saccharomyces cerevisiae YJL129C TRK1 Component of the Trk1p-Trk2p potassium transport system 180 kDa high affinity potassium transporter ZYRO0D03344g similar to uniprot|P08018 Saccharomyces cerevisiae YJL128C PBS2 MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway activated under severe osmotic stress ZYRO0D03366g some similarities with uniprot|P35208 Saccharomyces cerevisiae YJL127C SPT10 Putative histone acetylase required for transcriptional regulation at core promoters functions at or near the TATA box ZYRO0D03388g similar to uniprot|P47016 Saccharomyces cerevisiae YJL126W ZYRO0D03410g similar to uniprot|P46959 Saccharomyces cerevisiae YJL125C GCD14 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd10p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression ZYRO0D03432g highly similar to uniprot|P47017 Saccharomyces cerevisiae YJL124C LSM1 Component of small nuclear ribonucleoprotein complexes involved in mRNA decapping and decay ZYRO0D03454g similar to uniprot|P36141 Saccharomyces cerevisiae YKR049C FMP46 The authentic non-tagged protein was localized to the mitochondria ZYRO0D03476g similar to gnl|GLV|CAGL0L05522g Candida glabrata CAGL0L05522g and weakly similar to YJL123C uniprot|P47018 Saccharomyces cerevisiae YJL123C Hypothetical ORF ZYRO0D03498g similar to uniprot|P47019 Saccharomyces cerevisiae YJL122W Hypothetical ORF ZYRO0D03520g highly similar to uniprot|P46969 Saccharomyces cerevisiae YJL121C RPE1 D-ribulose-5-Phosphate 3-epimerase ZYRO0D03542g similar to uniprot|P25293 Saccharomyces cerevisiae YKR048C NAP1 Protein that interacts with mitotic cyclin Clb2p required for the regulation of microtubule dynamics during mitosis controls bud morphogenesis involved in the transport of H2A and H2B histones to the nucleus ZYRO0D03564g weakly similar to uniprot|P36139 Saccharomyces cerevisiae YKR046C PET10 Protein of unknown function that co-purifies with lipid particles expression pattern suggests a role in respiratory growth computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange ZYRO0D03586g some similarities with uniprot|P36138 Saccharomyces cerevisiae YKR045C ZYRO0D03608g similar to uniprot|P46956 Saccharomyces cerevisiae YJL117W PHO86 Protein specifically required for packaging of the high-affinity phosphate transporter Pho84p into COPII coated vesicles for transport to the plasma membrane transcription and localization are regulated by phosphate levels ZYRO0D03630g similar to uniprot|P36137 Saccharomyces cerevisiae YKR044W UIP5 Protein of unknown function ZYRO0D03652g similar to uniprot|P36136 Saccharomyces cerevisiae YKR043C Hypothetical ORF ZYRO0D03674g similar to gnl|GLV|CAGL0L03289g Candida glabrata CAGL0L03289g and some similarites with YKR042W uniprot|P36135 Saccharomyces cerevisiae YKR042W UTH1 Youth involved in determining yeast longevity involved in cell growth ZYRO0D03696g some similarities with uniprot|P32447 Saccharomyces cerevisiae YJL115W ASF1 Nucleosome assembly factor involved in chromatin assembly after DNA replication anti- silencing protein that causes derepression of silent loci when overexpressed ZYRO0D03718g weakly similar to uniprot|P36134 Saccharomyces cerevisiae YKR041W Hypothetical ORF ZYRO0D03762g similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease localization to the plasma membrane is regulated by nitrogen source ZYRO0D03784g highly similar to uniprot|P36132 Saccharomyces cerevisiae YKR038C KAE1 Putative glycoprotease that interacts with Bud32p which is a member of the novel protein kinase piD261 family ZYRO0D03806g similar to uniprot|P36131 Saccharomyces cerevisiae YKR037C SPC34 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle ZYRO0D03828g similar to uniprot|P47025 Saccharomyces cerevisiae YJL112W MDV1 WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission ZYRO0D03850g highly similar to uniprot|P42943 Saccharomyces cerevisiae YJL111W CCT7 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo ZYRO0D03872g highly similar to uniprot|P69771 Saccharomyces cerevisiae YKR035W-A DID2 Class E protein of the vacuolar protein-sorting (Vps) pathway associates reversibly with the late endosome has human ortholog that may be altered in breast tumors ZYRO0D03894g some similarities with uniprot|P42944 Saccharomyces cerevisiae YJL110C GZF3 GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding function requires a repressive carbon source dimerizes with Dal80p and binds to Tor1p ZYRO0D03916g similar to uniprot|P07261 Saccharomyces cerevisiae YPL075W GCR1 Transcriptional activator of genes involved in glycolysis functions and interacts with Gcr2p ZYRO0D03938g similar to uniprot|P40328 Saccharomyces cerevisiae YPL074W YTA6 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to the cortex of mother cells but not to daughter cells ZYRO0D03960g similar to uniprot|P38131 Saccharomyces cerevisiae YBR199W KTR4 Putative mannosyltransferase involved in protein glycosylation member of the KRE2/MNT1 mannosyltransferase family ZYRO0D03982g weakly similar to uniprot|Q02863 Saccharomyces cerevisiae YPL072W UBP16 Putative ubiquitin-specific protease ZYRO0D04004g similar to uniprot|P29366 Saccharomyces cerevisiae YBR200W BEM1 Protein containing SH3-domains involved in establishing cell polarity and morphogenesis functions as a scaffold protein for complexes that include Cdc24p Ste5p Ste20p and Rsr1p ZYRO0D04026g weakly similar to uniprot|Q02864 Saccharomyces cerevisiae YPL071C Hypothetical ORF ZYRO0D04048g similar to uniprot|Q02866 Saccharomyces cerevisiae YPL070W MUK1 Protein of unknown function localized to the cytoplasm computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation ZYRO0D04070g similar to uniprot|Q12051 Saccharomyces cerevisiae YPL069C BTS1 Geranylgeranyl diphosphate synthase increases the intracellular pool of geranylgeranyl diphosphate suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic ZYRO0D04092g similar to uniprot|P38307 Saccharomyces cerevisiae YBR201W DER1 Endoplasmic reticulum membrane protein required for the protein degradation process associated with the ER involved in the retrograde transport of misfolded or unassembled proteins ZYRO0D04114g similar to gnl|GLV|CAGL0H05225g Candida glabrata CAGL0H05225g and weakly similar to YPL067C uniprot|Q6Q586 Saccharomyces cerevisiae YPL067C Hypothetical ORF ZYRO0D04158g similar to uniprot|P19524 Saccharomyces cerevisiae YOR326W MYO2 One of two type V myosins involved in polarized distribution of mitochondria required for mitochondrion and vacuole inheritance and nuclear spindle orientation moves multiple cargo ZYRO0D04180g similar to uniprot|P33328 Saccharomyces cerevisiae YOR327C SNC2 mediate the targeting and transport of secretory proteins vesicle-associated membrane protein (synaptobrevin) homolog ZYRO0D04202g some similarities with uniprot|P34758 Saccharomyces cerevisiae YOR329C SCD5 Multicopy suppressor of clathrin deficiency and of ts ipl1 mutants ZYRO0D04224g no similarity ZYRO0D04246g similar to uniprot|P15801 Saccharomyces cerevisiae YOR330C MIP1 Catalytic subunit of the mitochondrial DNA polymerase ZYRO0D04268g similar to uniprot|P22203 Saccharomyces cerevisiae YOR332W VMA4 vacuolar ATPase V1 domain subunit E (27 kDa) ZYRO0D04290g similar to uniprot|Q01926 Saccharomyces cerevisiae YOR334W MRS2 Mitochondrial inner membrane Mg(2) channel required for maintenance of intramitochondrial Mg(2) concentrations at the correct level to support splicing of group II introns ZYRO0D04312g weakly similar to uniprot|P39732 Saccharomyces cerevisiae YAL031C FUN21 Cytoplasmic protein of unknown function potential Cdc28p substrate ZYRO0D04334g similar to uniprot|P28004 Saccharomyces cerevisiae YAL032C PRP45 Ortholog of human transcriptional coactivator SKIP can activate transcription of a reporter gene interacts with splicing factors Prp22p and Prp46p ZYRO0D04356g similar to uniprot|P28005 Saccharomyces cerevisiae YAL033W POP5 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends ZYRO0D04378g highly similar to uniprot|P40825 Saccharomyces cerevisiae YOR335C ALA1 Cytoplasmic alanyl-tRNA synthetase required for protein synthesis point mutation (cdc64-1 allele) causes cell cycle arrest at G1 lethality of null mutation is functionally complemented by human homolog ZYRO0D04400g similar to uniprot|P22023 Saccharomyces cerevisiae YOR336W KRE5 Protein required for beta-1 6 glucan biosynthesis mutations result in aberrant morphology and severe growth defects ZYRO0D04422g similar to uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Mutants are defective in Ty1 Enhancer-mediated Activation Ty1 enhancer activator and to YLR098C uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain DNA-binding transcriptional activator or CHA1 ZYRO0D04444g similar to uniprot|Q06855 Saccharomyces cerevisiae YOR338W Hypothetical ORF ZYRO0D04466g highly similar to uniprot|P52492 Saccharomyces cerevisiae YOR339C ZYRO0D04488g similar to uniprot|P39731 Saccharomyces cerevisiae YAL034W-A MTW1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules critical to kinetochore assembly ZYRO0D04510g similar to uniprot|P46669 Saccharomyces cerevisiae YOR340C RPA43 RNA polymerase I subunit A43 ZYRO0D04532g highly similar to uniprot|P10964 Saccharomyces cerevisiae YOR341W RPA190 RNA polymerase I subunit largest subunit of RNA polymerase I ZYRO0D04554g similar to uniprot|P39730 Saccharomyces cerevisiae YAL035W FUN12 GTPase required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining homolog of bacterial IF2 ZYRO0D04576g highly similar to uniprot|P39729 Saccharomyces cerevisiae YAL036C RBG1 GTPase that interacts with ribosomes member of the DRG family of GTP-binding proteins ZYRO0D04598g weakly similar to uniprot|Q12182 Saccharomyces cerevisiae YOR342C Hypothetical ORF ZYRO0D04642g some similarities with uniprot|P33122 Saccharomyces cerevisiae YOR344C TYE7 may be involved in glycolytic gene expression TYE7 a 33 kDa serine-rich protein is a potential member of the basic region/helix-loop- helix/leucine-zipper protein family ZYRO0D04664g similar to uniprot|P12689 Saccharomyces cerevisiae YOR346W REV1 Deoxycytidyl transferase forms a complex with the subunits of DNA polymerase zeta Rev3p and Rev7p involved in repair of abasic sites in damaged DNA ZYRO0D04686g highly similar to uniprot|P00549 Saccharomyces cerevisiae YAL038W CDC19 Pyruvate kinase functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration ZYRO0D04708g similar to uniprot|P40987 Saccharomyces cerevisiae YOR349W CIN1 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl ZYRO0D04730g weakly similar to uniprot|P24720 Saccharomyces cerevisiae YOR350C ZYRO0D04752g highly similar to uniprot|P24719 Saccharomyces cerevisiae YOR351C MEK1 Meiosis-specific serine/threonine protein kinase ZYRO0D04774g similar to uniprot|Q08816 Saccharomyces cerevisiae YOR352W Hypothetical ORF ZYRO0D04796g some similarites with uniprot|Q08817 Saccharomyces cerevisiae YOR353C SOG2 Protein required for cell viability ZYRO0D04818g similar to uniprot|P06182 Saccharomyces cerevisiae YAL039C CYC3 Cytochrome c heme lyase (holocytochrome c synthase) attaches heme to apo-Cyc1p in the mitochondrial intermembrane space human ortholog may have a role in microphthalmia with linear skin defects (MLS) ZYRO0D04840g weakly similar to uniprot|Q08818 Saccharomyces cerevisiae YOR354C MSC6 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to mitochondria msc6 mutants are defective in directing meiotic recombination events to homologous chromatids ZYRO0D04862g weakly similar to uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 role in cell cycle START involved in G(sub)1 size control G(sub)1 cyclin ZYRO0D04884g conserved hypothetical protein ZYRO0D04906g similar to uniprot|P41913 Saccharomyces cerevisiae YOR355W GDS1 Protein of unknown function required for growth on glycerol as a carbon source ZYRO0D04928g similar to uniprot|Q08822 Saccharomyces cerevisiae YOR356W Hypothetical ORF ZYRO0D04950g similar to gnl|GLV|KLLA0C12969g Kluyveromyces lactis KLLA0C12969g and some similarites with YAL041W uniprot|P11433 Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p required for polarity establishment and maintenance and mutants have morphological defects in bud formation and shmooing ZYRO0D04972g similar to uniprot|P39727 Saccharomyces cerevisiae YAL042W ERV46 Protein localized to COPII-coated vesicles forms a complex with Erv41p involved in the membrane fusion stage of transport ZYRO0D04994g similar to uniprot|Q08826 Saccharomyces cerevisiae YOR357C ZYRO0D05016g highly similar to uniprot|Q758Y6 Ashbya gossypii ADR391W ADR391Wp and similar to YOR358W uniprot|Q02516 Saccharomyces cerevisiae YOR358W HAP5 Subunit of the heme-activated glucose-repressed Hap2/3/4/5 CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression required for assembly and DNA binding activity of the complex ZYRO0D05038g similar to uniprot|Q01329 Saccharomyces cerevisiae YAL043C PTA1 Subunit of holo-CPF a multiprotein complex and functional homolog of mammalian CPSF required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends involved in pre-tRNA processing binds to the phosphorylated CTD of RNAPII ZYRO0D05060g some similarities with uniprot|Q08831 Saccharomyces cerevisiae YOR359W VTS1 ZYRO0D05082g similar to uniprot|P06776 Saccharomyces cerevisiae YOR360C PDE2 High-affinity cyclic AMP phosphodiesterase component of the cAMP-dependent protein kinase signaling system protects the cell from extracellular cAMP contains readthrough motif surrounding termination codon ZYRO0D05104g weakly similar to uniprot|P39734 Saccharomyces cerevisiae YAL028W FRT2 Tail-anchored endoplasmic reticulum membrane protein interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p) promotes growth in conditions of high Na alkaline pH or cell wall stress potential Cdc28p substrate ZYRO0D05126g similar to uniprot|P39735 Saccharomyces cerevisiae YAL027W Hypothetical ORF ZYRO0D05148g highly similar to uniprot|P54885 Saccharomyces cerevisiae YOR323C PRO2 Gamma-glutamyl phosphate reductase catalyzes the second step in proline biosynthesis ZYRO0D05170g highly similar to uniprot|P39524 Saccharomyces cerevisiae YAL026C DRS2 Integral membrane Ca(2)-ATPase potential aminophospholipid translocase required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption mutation affects maturation of the 18S rRNA ZYRO0D05192g some similarities with uniprot|P10962 Saccharomyces cerevisiae YAL025C MAK16 Essential nuclear protein required for normal concentration of free 60S ribosomal subunits required for maintenance of M1 satellite double- stranded RNA of the L-A virus ZYRO0D05214g similar to uniprot|P07866 Saccharomyces cerevisiae YAL024C LTE1 Putative GDP/GTP exchange factor required for mitotic exit at low temperatures acts as a guanine nucleotide exchange factor (GEF) for Tem1p which is a key regulator of mitotic exit physically associates with Ras2p-GTP ZYRO0D05236g similar to uniprot|Q12502 Saccharomyces cerevisiae YOR322C Hypothetical ORF ZYRO0D05258g highly similar to uniprot|P31382 Saccharomyces cerevisiae YAL023C PMT2 Transfers mannosyl residues from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins acts in complex with Pmt1p dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase ZYRO0D05280g similar to uniprot|P31381 Saccharomyces cerevisiae YAL022C FUN26 Nucleoside transporter with broad nucleoside selectivity localized to intracellular membranes ZYRO0D05302g similar to uniprot|P31384 Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex which is involved in regulation of gene expression component of the major cytoplasmic deadenylase which is involved in mRNA poly(A) tail shortening ZYRO0D05324g similar to uniprot|P31386 Saccharomyces cerevisiae YAL020C ATS1 Protein with a potential role in regulatory interactions between microtubules and the cell cycle as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1 ZYRO0D05346g similar to uniprot|P31380 Saccharomyces cerevisiae YAL019W FUN30 Protein whose overexpression affects chromosome stability potential Cdc28p substrate homolog of Snf2p ZYRO0D05368g weakly similar to uniprot|P19659 Saccharomyces cerevisiae YOL051W GAL11 Component of the Mediator complex interacts with RNA polymerase II and the general transcription factors to form the RNA polymerase II holoenzyme affects transcription by acting as target of activators and repressors ZYRO0D05390g similar to uniprot|Q08220 Saccharomyces cerevisiae YOL049W GSH2 Glutathione synthetase catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine induced by oxidative stress and heat shock ZYRO0D05412g weakly similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF ZYRO0D05434g conserved hypothetical protein ZYRO0D05456g weakly similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF ZYRO0D05478g similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF ZYRO0D05500g weakly similar to uniprot|P31374 Saccharomyces cerevisiae YAL017W PSK1 One of two (see also PSK2) PAS domain containing S/T protein kinases coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status ZYRO0D05522g some similarities with uniprot|Q08215 Saccharomyces cerevisiae YOL044W PEX15 Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol overexpression results in impaired peroxisome assembly ZYRO0D05544g highly similar to uniprot|P31383 Saccharomyces cerevisiae YAL016W TPD3 protein phosphatase 2A regulatory subunit A ZYRO0D05566g similar to uniprot|Q08214 Saccharomyces cerevisiae YOL043C NTG2 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase ZYRO0D05588g similar to uniprot|Q08213 Saccharomyces cerevisiae YOL042W ZYRO0D05610g no similarity ZYRO0D05632g similar to uniprot|P31377 Saccharomyces cerevisiae YAL014C SYN8 Endosomal SNARE related to mammalian syntaxin 8 ZYRO0D05654g similar to uniprot|Q08208 Saccharomyces cerevisiae YOL041C ZYRO0D05676g some similarities with uniprot|P31385 Saccharomyces cerevisiae YAL013W DEP1 Transcriptional modulator involved in the regulation of structural genes involved in phospholipid biosynthesis also participates in regulation of metabolically unrelated genes as well as maintenance of mating efficiency and sporulation ZYRO0D05698g similar to uniprot|Q01855 Saccharomyces cerevisiae YOL040C ZYRO0D05720g highly similar to uniprot|P05319 Saccharomyces cerevisiae YOL039W RPP2A Ribosomal protein P2 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm ZYRO0D05742g highly similar to uniprot|P31373 Saccharomyces cerevisiae YAL012W CYS3 Cystathionine gamma-lyase catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine ZYRO0D05764g similar to uniprot|Q6B1H9 Saccharomyces cerevisiae YOL031C SIL1 ER-localized protein required for protein translocation into the ER interacts with the ATPase domain of the Kar2p chaperone suggesting some role in modulating its activity homolog of Yarrowia lipolytica SLS1 GrpE-like protein in the ER ZYRO0D05786g similar to uniprot|Q08202 Saccharomyces cerevisiae YOL032W Hypothetical ORF ZYRO0D05808g similar to uniprot|P48525 Saccharomyces cerevisiae YOL033W MSE1 Mitochondrial glutamyl-tRNA synthetase encoded by a nuclear gene ZYRO0D05830g some similarities with uniprot|P22470 Saccharomyces cerevisiae YDR143C SAN1 Ubiquitin-protein ligase controls turnover of a specific class of unstable nuclear proteins including Sir4p but not Sir2p or Sir3p san1 mutations suppress sir4 spt16 and cdc68 mutations suggesting a role in chromatin silencing ZYRO0D05852g similar to uniprot|P39108 Saccharomyces cerevisiae YDR142C PEX7 May serve as intraperoxisomal receptor for type 2 peroxisomal proteins (such as thiolase) Member of beta-transducin-related (WD-40) protein family ZYRO0D05874g weakly similar to uniprot|Q99176 Saccharomyces cerevisiae YLR119W SRN2 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome suppressor of rna1-1 mutation may be involved in RNA export from nucleus ZYRO0D05896g similar to uniprot|Q12354 Saccharomyces cerevisiae YLR118C ZYRO0D05918g similar to uniprot|Q03921 Saccharomyces cerevisiae YDR141C DOP1 ZYRO0D05940g similar to uniprot|Q03920 Saccharomyces cerevisiae YDR140W MTQ2 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family methylates release factor eRF1 (Sup45p) in vitro ZYRO0D05962g similar to uniprot|Q03919 Saccharomyces cerevisiae YDR139C RUB1 Ubiquitin-like protein with similarity to mammalian NEDD8 ZYRO0D05984g similar to uniprot|Q12309 Saccharomyces cerevisiae YLR117C CLF1 SYnthetic lethal with cdcForty Crooked neck Like Factor an ortholog of the Drosophila crooked neck gene crn pre-mRNA splicing factor ZYRO0D06006g similar to uniprot|Q12186 Saccharomyces cerevisiae YLR116W MSL5 Component of the commitment complex which defines the first step in the splicing pathway essential protein that interacts with Mud2p and Prp40p forming a bridge between the intron ends also involved in nuclear retention of pre-mRNA ZYRO0D06028g similar to uniprot|Q12102 Saccharomyces cerevisiae YLR115W ZYRO0D06050g conserved hypothetical protein ZYRO0D06072g similar to uniprot|P17629 Saccharomyces cerevisiae YDR138W ZYRO0D06094g similar to uniprot|Q12500 Saccharomyces cerevisiae YLR114C AVL9 PHO85 Requiring ZYRO0D06116g similar to uniprot|P16664 Saccharomyces cerevisiae YDR137W RGP1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p ZYRO0D06160g highly similar to uniprot|P39109 Saccharomyces cerevisiae YDR135C ZYRO0D06182g uniprot|O93982 Zygosaccharomyces rouxii HOG1 Mitogen- activated protein kinase HOG1 ZYRO0D06204g some similarities with uniprot|Q12127 Saccharomyces cerevisiae YLR110C CCW12 Cell wall protein mutants are defective in mating and agglutination expression is downregulated by alpha-factor ZYRO0D06248g similar to uniprot|P38013 Saccharomyces cerevisiae YLR109W AHP1 Thiol-specific peroxiredoxin reduces hydroperoxides to protect against oxidative damage function in vivo requires covalent conjugation to Urm1p ZYRO0D06270g similar to uniprot|Q03900 Saccharomyces cerevisiae YDR132C Hypothetical ORF ZYRO0D06314g similar to uniprot|Q03899 Saccharomyces cerevisiae YDR131C Hypothetical ORF ZYRO0D06336g weakly similar to uniprot|Q03898 Saccharomyces cerevisiae YDR130C FIN1 Basic protein with putative coiled-coil regions that comprises a filament between spindle pole bodies self-assembles into filaments with a diameter of approximately 10 nm potential Cdc28p substrate ZYRO0D06358g similar to uniprot|Q7LI70 Saccharomyces cerevisiae YLR107W REX3 RNA exonuclease required for maturation of the RNA component of RNase MRP functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA member of RNase D family of exonucleases ZYRO0D06380g similar to uniprot|Q12019 Saccharomyces cerevisiae YLR106C MDN1 Huge dynein-related AAA-type ATPase (midasin) forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p) may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm ZYRO0D06424g similar to uniprot|P16658 Saccharomyces cerevisiae YLR105C ZYRO0D06446g similar to uniprot|Q08045 Saccharomyces cerevisiae YLR104W Hypothetical ORF ZYRO0D06468g highly similar to uniprot|Q08032 Saccharomyces cerevisiae YLR103C CDC45 DNA replication initiation factor ZYRO0D06490g similar to uniprot|Q12107 Saccharomyces cerevisiae YLR102C APC9 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition ZYRO0D06512g highly similar to uniprot|P32599 Saccharomyces cerevisiae YDR129C SAC6 Fimbrin actin-bundling protein cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton ZYRO0D06534g similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants are sterol auxotrophs ZYRO0D06556g similar to uniprot|Q03897 Saccharomyces cerevisiae YDR128W Hypothetical ORF ZYRO0D06578g highly similar to uniprot|P08566 Saccharomyces cerevisiae YDR127W ARO1 Pentafunctional arom protein catalyzes steps 2 through 6 in the biosynthesis of chorismate which is a precursor to aromatic amino acids ZYRO0D06600g similar to uniprot|Q04629 Saccharomyces cerevisiae YDR126W SWF1 Spore Wall Formation ZYRO0D06622g no similarity ZYRO0D06644g some similarities with uniprot|Q3E798 Saccharomyces cerevisiae YLR099W-A Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. ZYRO0D06666g similar to uniprot|Q04623 Saccharomyces cerevisiae YDR125C ZYRO0D06688g similar to uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain DNA-binding transcriptional activator or CHA1 ZYRO0D06710g weakly similar to uniprot|Q04608 Saccharomyces cerevisiae YDR124W Hypothetical ORF ZYRO0D06732g similar to uniprot|Q12347 Saccharomyces cerevisiae YLR097C HRT3 Putative nuclear ubiquitin ligase based on computational analysis of large-scale protein-protein interaction data ZYRO0D06754g weakly similar to uniprot|P26798 Saccharomyces cerevisiae YDR123C INO2 Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs) required for derepression of phospholipid biosynthetic genes in response to inositol depletion ZYRO0D06776g similar to uniprot|P13186 Saccharomyces cerevisiae YLR096W KIN2 Serine/threonine protein kinase involved in regulation of exocytosis localizes to the cytoplasmic face of the plasma membrane closely related to Kin1p and to YDR122W uniprot|P13185 Saccharomyces cerevisiae YDR122W KIN1 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p ZYRO0D06798g similar to uniprot|Q12072 Saccharomyces cerevisiae YLR095C IOC2 Member of a complex (Isw1b) with Isw1p and Ioc4p ZYRO0D06820g some similarities with uniprot|Q7LGX3 Saccharomyces cerevisiae YLR094C GIS3 Protein of unknown function ZYRO0D06842g similar to uniprot|Q12255 Saccharomyces cerevisiae YLR093C NYV1 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion inhibits ATP-dependent Ca(2) transport activity of Pmc1p in the vacuolar membrane ZYRO0D06864g some similarities with uniprot|Q04603 Saccharomyces cerevisiae YDR121W DPB4 Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex involved in both chromosomal DNA replication and in inheritance of telomeric silencing ZYRO0D06886g similar to uniprot|P15565 Saccharomyces cerevisiae YDR120C TRM1 tRNA methyltransferase localizes to both the nucleus and mitochondrion to produce the modified base N2 N2-dimethylguanosine in tRNAs in both compartments ZYRO0D06908g similar to uniprot|Q2V2P9 Saccharomyces cerevisiae YDR119W-A ZYRO0D06930g some similarities with uniprot|P53335 Saccharomyces cerevisiae YGR280C PXR1 Protein with a role in maturation of rRNAs and small nucleolar RNAs required for cell viability ZYRO0D06952g similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor ZYRO0D06974g highly similar to uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3 Protein of unknown function has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p ZYRO0D06996g some similarities with uniprot|P53334 Saccharomyces cerevisiae YGR279C ZYRO0D07018g similar to uniprot|P53333 Saccharomyces cerevisiae YGR278W CWC22 Essential protein component of a complex containing Cef1p has similarity to S. pombe Cwf22p putative spliceosomal component based on computational analysis of large-scale protein-protein interaction data ZYRO0D07040g similar to uniprot|P53332 Saccharomyces cerevisiae YGR277C Homolog to human PPAT ZYRO0D07062g similar to uniprot|P50101 Saccharomyces cerevisiae YMR304W UBP15 Ubiquitin-specific protease that may play a role in ubiquitin precursor processing ZYRO0D07084g similar to uniprot|P32843 Saccharomyces cerevisiae YMR302C PRP12 Integral inner mitochondrial membrane protein with similarity to exonucleases ZYRO0D07106g similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane transporter exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol member of the ATP-binding cassette (ABC) transporter family ZYRO0D07128g highly similar to uniprot|P04046 YMR300C Saccharomyces cerevisiae ADE4 Phosphoribosylpyrophosphate amidotransferase ZYRO0D07150g weakly similar to uniprot|Q04949 Saccharomyces cerevisiae YMR299C DYN3 Dynein light intermediate chain (LIC) localizes with dynein null mutant is defective in nuclear migration ZYRO0D07172g similar to uniprot|P53331 Saccharomyces cerevisiae YGR276C RNH70 3' exoribonuclease required for 5S and tRNA-Arg3 maturation ZYRO0D07194g weakly similar to uniprot|P53330 Saccharomyces cerevisiae YGR275W RTT102 Regulator of Ty1 Transposition regulator of Ty1 transposition ZYRO0D07216g similar to uniprot|P46677 YGR274C Saccharomyces cerevisiae TAF1 TFIID subunit (145 kDa) involved in RNA polymerase II transcription initiation ZYRO0D07238g similar to uniprot|Q03579 Saccharomyces cerevisiae YMR298W Protein required for cell viability ZYRO0D07260g highly similar to uniprot|P00729 Saccharomyces cerevisiae YMR297W PRC1 Vacuolar carboxypeptidase Y (proteinase C) involved in protein degradation in the vacuole and required for full protein degradation during sporulation ZYRO0D07282g similar to uniprot|P25045 YMR296C Saccharomyces cerevisiae LCB1 Component of serine palmitoyltransferase responsible along with Lcb2p for the first committed step in sphingolipid synthesis ZYRO0D07304g similar to uniprot|Q03559 YMR295C Saccharomyces cerevisiae Protein of unknown function ZYRO0D07326g similar to uniprot|P53328 YGR272C Saccharomyces cerevisiae Hypothetical ORF ZYRO0D07348g highly similar to uniprot|P53327 Saccharomyces cerevisiae YGR271W SLH1 SKI2-like helicase ZYRO0D07370g similar to uniprot|P36224 Saccharomyces cerevisiae YMR294W JNM1 Component of the yeast dynactin complex consisting of Nip100p Jnm1p and Arp1p required for proper nuclear migration and spindle partitioning during mitotic anaphase B ZYRO0D07392g similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C Uncharacterized ORF ZYRO0D07414g similar to uniprot|P40340 Saccharomyces cerevisiae YGR270W YTA7 Protein of unknown function member of CDC48/PAS1/SEC18 family of ATPases potentially phosphorylated by Cdc28p ZYRO0D07436g similar to uniprot|Q03554 YMR292w Saccharomyces GOT1 evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes ZYRO0D07458g similar to uniprot|P40325 YGR268C Saccharomyces cerevisiae HUA1 uncharacterized ORF ZYRO0D07480g highly similar to uniprot|P51601 YGR267C Saccharomyces cerevisiae FOL2 GTP-cyclohydrolase I ZYRO0D07502g similar to uniprot|Q03533 Saccharomyces cerevisiae YMR291W Hypothetical ORF ZYRO0D07524g similar to uniprot|P53326 YGR266W Saccharomyces cerevisiae probably contains a single transmembrane span ZYRO0D07546g highly similar to uniprot|Q03532 Saccharomyces cerevisiae YMR290C HAS1 ATP-dependent RNA helicase localizes to both the nuclear periphery and nucleolus highly enriched in nuclear pore complex fractions ZYRO0D07568g highly similar to uniprot|P00958 Saccharomyces cerevisiae YGR264C MES1 Methionyl-tRNA synthetase forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p which increases the catalytic efficiency of both tRNA synthetases also has a role in nuclear export of tRNAs ZYRO0D07590g weakly similar to uniprot|P53324 Saccharomyces cerevisiae YGR263C ZYRO0D07612g highly similar to uniprot|P53323 Saccharomyces cerevisiae YGR262C BUD32 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ZYRO0D07634g similar to uniprot|Q74Z76 Ashbya gossypii AGR330W AGR330Wp and weakly similar to YMR289W uniprot|Q03266 Saccharomyces cerevisiae YMR289W ABZ2 4-amino-4-deoxychorismate lyase catalyzes the third step in para-aminobenzoic acid biosynthesis ZYRO0D07656g similar to uniprot|P46682 Saccharomyces cerevisiae YGR261C APL6 beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function putative beta adaptin component of the membrane-associate clathrin assembly complex ZYRO0D07678g similar to uniprot|P49955 Saccharomyces cerevisiae YMR288W HSH155 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 ZYRO0D07700g similar to uniprot|P38875 Saccharomyces cerevisiae YHR188C GPI16 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins human PIG-Tp homolog ZYRO0D07722g similar to uniprot|P38874 Saccharomyces cerevisiae YHR187W IKI1 Subunit of the Elp4p-Iki1p-Elp6p-subcomplex of RNA polymerase II elongator complex which is a histone acetyltransferase iki1 mutations confer resistance to the K. lactis toxin zymocin ZYRO0D07744g similar to gnl|GLV|CAGL0M13409g Candida glabrata CAGL0M13409g and some similarites with YHR186C uniprot|P38873 Saccharomyces cerevisiae YHR186C KOG1 Subunit of TORC1 a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p Lst8p and Tco89p contains four HEAT repeats and seven WD-40 repeats may act as a scaffold protein to couple TOR and its effectors ZYRO0D07788g similar to uniprot|P07276 Saccharomyces cerevisiae YGR258C RAD2 Single-stranded DNA endonuclease cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPG protein ZYRO0D07810g weakly similar to uniprot|P38872 Saccharomyces cerevisiae YHR185C PFS1 Sporulation protein required for prospore membrane formation at selected spindle poles ensures functionality of all four spindle pole bodies of a cell during meiosis II not required for meiotic recombination or meiotic chromosome segregation ZYRO0D07832g similar to uniprot|P53320 Saccharomyces cerevisiae YGR257C MTM1 Mitochondrial protein of the mitochondrial carrier family involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor ZYRO0D07854g weakly similar to uniprot|P38871 Saccharomyces cerevisiae YHR184W SSP1 Protein involved in the control of meiotic nuclear division and spore formation ZYRO0D07876g highly similar to uniprot|P53319 Saccharomyces cerevisiae YGR256W GND2 and to uniprot|P38720 Saccharomyces cerevisiae YHR183W GND1 6-phosphogluconate dehydrogenase(decarboxylating) ZYRO0D07898g highly similar to uniprot|P38869 Saccharomyces cerevisiae YHR181W SVP26 Component of Sed5p vesicles ZYRO0D07942g highly similar to uniprot|P53731 Saccharomyces cerevisiae YNR035C ARC35 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches required for cortical localization of calmodulin ZYRO0D07964g similar to uniprot|P25644 Saccharomyces cerevisiae YCR077C PAT1 Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor also required for faithful chromosome transmission maintenance of rDNA locus stability and protection of mRNA 3'-UTRs from trimming functionally linked to Pab1p ZYRO0D07986g some similarities with uniprot|P25659 Saccharomyces cerevisiae YCR076C ZYRO0D08008g similar to uniprot|Q3E830 Saccharomyces cerevisiae YCR075W-A Identified by homology to Ashbya gossypii ZYRO0D08030g conserved hypothetical protein ZYRO0D08052g some similarities with uniprot|P40530 Saccharomyces cerevisiae YIL042C ZYRO0D08074g similar to uniprot|P17261 Saccharomyces cerevisiae YCR075C ZYRO0D08096g similar to uniprot|P50278 Saccharomyces cerevisiae YNR034W ZYRO0D08118g similar to uniprot|P37254 Saccharomyces cerevisiae YNR033W ZYRO0D08140g similar to uniprot|Q6Q546 Saccharomyces cerevisiae YNR032C-A HUB1 ZYRO0D08162g highly similar to uniprot|P32838 Saccharomyces cerevisiae YNR032W PPG1 Putative serine/threonine protein phosphatase required for glycogen accumulation interacts with Tap42p which binds to and regulates other protein phosphatases ZYRO0D08184g similar to uniprot|P53599 Saccharomyces cerevisiae YNR031C SSK2 Suppressor of Sensor Kinase (SLN1) A MAP kinase kinase kinase activator of Pbs2p ZYRO0D08206g highly similar to uniprot|P25382 Saccharomyces cerevisiae YCR072C Protein required for cell viability ZYRO0D08228g similar to uniprot|P25642 Saccharomyces cerevisiae YCR071C IMG2 Mitochondrial ribosomal protein of the small subunit ZYRO0D08250g similar to uniprot|P53730 Saccharomyces cerevisiae YNR030W ECM39 Alpha-1 6-mannosyltransferase localized to the ER responsible for the addition of the alpha-1 6 mannose to dolichol-linked Man7GlcNAc2 acts in the dolichol pathway for N-glycosylation ZYRO0D08272g similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Hypothetical ORF ZYRO0D08294g similar to uniprot|P25334 Saccharomyces cerevisiae YCR069W CPR4 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues has a potential role in the secretory pathway ZYRO0D08316g conserved hypothetical protein ZYRO0D08338g similar to uniprot|P25641 Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway ZYRO0D08360g similar to uniprot|P53727 Saccharomyces cerevisiae YNR027W BUD17 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ZYRO0D08382g similar to uniprot|P11655 Saccharomyces cerevisiae YNR026C SEC12 Guanine nucleotide exchange factor (GEF) glycosylated integral membrane protein of the endoplasmic reticulum important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p ZYRO0D08404g similar to uniprot|P10862 Saccharomyces cerevisiae YCR066W RAD18 Protein involved in postreplication repair binds single-stranded DNA and has single-stranded DNA dependent ATPase activity forms heterodimer with Rad6p contains RING-finger motif ZYRO0D08426g some similarities with uniprot|P25364 Saccharomyces cerevisiae YCR065W HCM1 Forkhead transcription factor involved in cell cycle specific transcription of SPC110 encoding a spindle pole body (SPB) calmodulin binding protein dosage-dependent suppressor of calmodulin mutants with specific defects in SPB assembly ZYRO0D08448g similar to uniprot|P25337 Saccharomyces cerevisiae YCR063W BUD31 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ZYRO0D08492g similar to gnl|GLV|CAGL0K09218g Candida glabrata CAGL0K09218g and some similarites with YCR061W uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0D08514g similar to uniprot|P25637 Saccharomyces cerevisiae YCR059C YIH1 piecemeal microautophagy of the nucleus (PMN) ZYRO0D08536g conserved hypothetical protein ZYRO0D08558g highly similar to uniprot|P25636 Saccharomyces cerevisiae YCR057C PWP2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Eight WD-repeats with homology with G protein beta subunits flanked by nonhomologous N-terminal and C-terminal extensions regulatory protein ZYRO0D08580g similar to uniprot|P25355 Saccharomyces cerevisiae YCR054C CTR86 Essential protein of unknown function ZYRO0D08602g highly similar to uniprot|P16120 Saccharomyces cerevisiae YCR053W THR4 threonine synthase ZYRO0D08624g similar to uniprot|P53628 Saccharomyces cerevisiae YNR023W SNF12 73 kDa subunit of the SWI/SNF transcription activation complex homolog of Rsc6p subunit of the RSC chromatin remodeling complex ZYRO0D08646g similar to uniprot|P53724 Saccharomyces cerevisiae YNR022C MRPL50 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation ZYRO0D08668g similar to uniprot|P53723 Saccharomyces cerevisiae YNR021W Hypothetical ORF ZYRO0D08690g highly similar to gnl|GLV|CAGL0C03003g Candida glabrata CAGL0C03003g and similar to YCR051W uniprot|P25631 Saccharomyces cerevisiae YCR051W Hypothetical ORF ZYRO0D08712g highly similar to gnl|GLV|KLLA0C09130g Kluyveromyces lactis KLLA0C09130g and similar to YNR020C uniprot|P53722 Saccharomyces cerevisiae YNR020C Hypothetical ORF ZYRO0D08734g similar to uniprot|P53629 Saccharomyces cerevisiae YNR019W ARE2 Acyl-CoA:sterol acyltransferase isozyme of Are1p endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen ZYRO0D08756g highly similar to uniprot|P25627 Saccharomyces cerevisiae YCR047C BUD23 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ZYRO0D08778g similar to uniprot|P25626 Saccharomyces cerevisiae YCR046C IMG1 Mitochondrial ribosomal protein of the small subunit required for respiration and for maintenance of the mitochondrial genome ZYRO0D08800g similar to uniprot|P53721 Saccharomyces cerevisiae YNR018W Hypothetical ORF ZYRO0D08822g similar to uniprot|P25381 Saccharomyces cerevisiae YCR045C Hypothetical ORF ZYRO0D08844g similar to uniprot|P32897 Saccharomyces cerevisiae YNR017W MAS6 Essential protein of the mitochondrial inner membrane component of the mitochondrial import system ZYRO0D08866g no similarity ZYRO0D08888g no similarity ZYRO0D08910g highly similar to uniprot|Q00955 Saccharomyces cerevisiae YNR016C ACC1 Acetyl-CoA carboxylase biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA required for de novo biosynthesis of long-chain fatty acids or YMR207C uniprot|P32874 Saccharomyces cerevisiae YMR207C HFA1 Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis ZYRO0D08932g similar to uniprot|P53720 Saccharomyces cerevisiae YNR015W SMM1 Dihydrouridine synthase ZYRO0D08954g some similarities with uniprot|P47179 Saccharomyces cerevisiae YJR151C ZYRO0D08976g some similarities with uniprot|P53719 Saccharomyces cerevisiae YNR014W ZYRO0D08998g similar to uniprot|P27514 Saccharomyces cerevisiae YNR013C PHO91 Low-affinity phosphate transporter deletion of pho84 pho87 pho89 pho90 and pho91 causes synthetic lethality transcription independent of Pi and Pho4p activity overexpression results in vigorous growth ZYRO0D09020g similar to uniprot|P27515 Saccharomyces cerevisiae YNR012W URK1 converts ATP and uridine to ADP and UMP Uridine kinase ZYRO0D09042g similar to uniprot|P20095 Saccharomyces cerevisiae YNR011C PRP2 RNA-dependent ATPase in the DEAH-box family required for activation of the spliceosome before the first transesterification step in RNA splicing ZYRO0D09064g highly similar to uniprot|P50107 Saccharomyces cerevisiae YML004C GLO1 Monomeric glyoxalase I catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione expression regulated by methylglyoxal levels and osmotic stress ZYRO0D09086g similar to uniprot|O59831 Schizosaccharomyces pombe SPCC965 Putative amino-acid permease C965.11c and weakly similar to YFL055W uniprot|P43548 Saccharomyces cerevisiae YFL055W AGP3 Low-affinity amino acid permease may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions transcription is induced under conditions of sulfur limitation ZYRO0D09108g similar to uniprot|O59832 Schizosaccharomyces pombe SPCC965 SPCC965.12 protein ZYRO0D09130g highly similar to uniprot|P16862 Saccharomyces cerevisiae YMR205C PFK2 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis indispensable for anaerobic growth activated by fructose-2 6-bisphosphate and AMP mutation inhibits glucose induction of cell cycle-related genes ZYRO0D09152g some similarities with uniprot|Q03694 Saccharomyces cerevisiae YMR204C Hypothetical ORF ZYRO0D09174g some similarities with uniprot|P03069 Saccharomyces cerevisiae YEL009C GCN4 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation expression is tightly regulated at both the transcriptional and translational levels ZYRO0D09196g some similarities with uniprot|P40002 Saccharomyces cerevisiae YEL007W Hypothetical ORF and some similarities with YHR177W uniprot|P38867 Saccharomyces cerevisiae YHR177W ZYRO0D09218g similar to uniprot|P40556 Saccharomyces cerevisiae YIL006W Pvruvate transporter of the mitochondrial inner membrane member of the mitochondrial carrier family has putative mouse and human orthologs ZYRO0D09240g similar to uniprot|P40557 YIL005W Saccharomyces cerevisiae EPS1 protein disulfide isomerase related protein involved in endoplasmic reticulum retention of resident ER proteins ZYRO0D09262g similar to gnl|GLV|CAGL0J02090g Candida glabrata CAGL0J02090g and weakly similar to YIL004C uniprot|P22804 Saccharomyces cerevisiae ZYRO0D09284g similar to uniprot|P40558 Saccharomyces cerevisiae YIL003W CFD1 Highly conserved putative P-loop ATPase localized in the cytoplasm has a potential role in assembly of iron-sulfur clusters in proteins ZYRO0D09306g some similarities with uniprot|P40003 Saccharomyces cerevisiae YEL005C VAB2 Protein with a potential role in vacuolar function as suggested by its ability to bind Vac8p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0D09328g similar to uniprot|P40005 YEL003w Saccharomyces cerevisiae GIM4 subunit of the heterohexameric cochaperone prefoldin complex ZYRO0D09350g similar to uniprot|P33767 YEL002C Saccharomyces cerevisiae WBP1 wheat germ agglutinin-binding protein oligosaccharyl transferase glycoprotein complex beta subunit ZYRO0D09372g no similarity ZYRO0D09394g similar to uniprot|P40559 YIL002C Saccharomyces cerevisiae INP51 Phosphatidylinositol 4 5-bisphosphate 5-phosphatase ZYRO0D09416g similar to uniprot|P40560 YIL001W Saccharomyces cerevisiae Hypothetical ORF ZYRO0D09438g weakly similar to uniprot|P40006 Saccharomyces cerevisiae YEL001C Hypothetical ORF ZYRO0D09482g similar to uniprot|P40561 Saccharomyces cerevisiae YIR001C SGN1 Cytoplasmic RNA-binding protein contains an RNA recognition motif (RRM) may have a role in mRNA translation as suggested by genetic interactions with genes encoding proteins involved in translational initiation ZYRO0D09504g similar to uniprot|P40007 YER002W Saccharomyces cerevisiae NOP16 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis ZYRO0D09526g highly similar to uniprot|P29952 YER003C Saccharomyces cerevisiae PMI40 mannose-6-phosphate isomerase ZYRO0D09548g similar to uniprot|P40008 Saccharomyces cerevisiae YER004W FMP52 The authentic non-tagged protein was localized to the mitochondria ZYRO0D09570g similar to uniprot|P40009 YER005W Saccharomyces cerevisiae YND1 Yeast Nucleoside Diphosphatase ZYRO0D09592g similar to uniprot|P40010 Saccharomyces cerevisiae YER006W NUG1 GTPase that associates with nuclear 60S pre-ribosomes required for export of 60S ribosomal subunits from the nucleus ZYRO0D09614g similar to uniprot|P39937 Saccharomyces cerevisiae YER007W PAC2 Microtubule effector required for tubulin heterodimer formation binds alpha-tubulin required for normal microtubule function null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl ZYRO0D09636g similar to uniprot|P89886 Saccharomyces cerevisiae YER007C-A TMA20 Protein of unknown function that associates with ribosomes ZYRO0D09658g no similarity ZYRO0D09680g similar to uniprot|Q12374 Saccharomyces cerevisiae YPR155C NCA2 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase functions with Nca3p ZYRO0D09702g weakly similar to uniprot|Q06449 Saccharomyces cerevisiae YPR154W PIN3 Protein that induces appearance of [PIN ] prion when overproduced ZYRO0D09724g similar to uniprot|Q06HN0 Saccharomyces cerevisiae YPR153W Hypothetical ORF ZYRO0D09746g highly similar to uniprot|P23638 Saccharomyces cerevisiae YGR135W PRE9 20S proteasome beta-type subunit the only nonessential 20S subunit ZYRO0D09768g similar to uniprot|Q06525 Saccharomyces cerevisiae YPR152C ZYRO0D09790g similar to uniprot|P53280 Saccharomyces cerevisiae YGR134W CAF130 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation ZYRO0D09812g similar to gnl|GLV|CAGL0L08426g Candida glabrata CAGL0L08426g and weakly similar to YPR151C uniprot|Q06524 Saccharomyces cerevisiae YPR151C SUE1 Mitochondrial protein required for degradation of unstable forms of cytochrome c ZYRO0D09856g some similarities with uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 ZYRO0D09878g similar to uniprot|P29340 Saccharomyces cerevisiae YGR133W PEX4 Involved in peroxisome biogenesis Member of ubiquitin-conjugating protein family ZYRO0D09900g similar to uniprot|P40961 Saccharomyces cerevisiae YGR132C ZYRO0D09922g similar to uniprot|Q06593 Saccharomyces cerevisiae YPR194C OPT2 Oligopeptide transporter member of the OPT family with potential orthologs in S. pombe and C. albicans ZYRO0D09944g no similarity ZYRO0D09966g weakly similar to uniprot|Q12207 Saccharomyces cerevisiae YPR149W NCE102 and to uniprot|P53279 Saccharomyces cerevisiae YGR131W ZYRO0D09988g weakly similar to uniprot|P53278 Saccharomyces cerevisiae YGR130C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0D10010g similar to uniprot|Q06523 Saccharomyces cerevisiae YPR148C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0D10032g similar to uniprot|P53277 Saccharomyces cerevisiae YGR129W SYF2 SYnthetic lethal with cdcForty (putative) involved in pre-mRNA splicing ZYRO0D10054g similar to uniprot|P53276 Saccharomyces cerevisiae YGR128C UTP8 Nucleolar protein required for export of tRNAs from the nucleus also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0D10076g similar to uniprot|Q06522 Saccharomyces cerevisiae YPR147C Hypothetical ORF ZYRO0D10098g similar to uniprot|P53275 Saccharomyces cerevisiae YGR127W Hypothetical ORF ZYRO0D10120g similar to uniprot|Q06675 Saccharomyces cerevisiae YDR318W MCM21 Protein involved in minichromosome maintenance component of the COMA complex that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules ZYRO0D10142g similar to uniprot|Q06676 Saccharomyces cerevisiae YDR319C Hypothetical ORF ZYRO0D10164g highly similar to uniprot|P38604 Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase an essential enzyme that catalyzes the cyclization of squalene 2 3-epoxide a step in ergosterol biosynthesis ZYRO0D10186g similar to uniprot|Q06677 Saccharomyces cerevisiae YDR320C SWA2 auxilin-like protein ZYRO0D10208g highly similar to uniprot|Q6Q547 Saccharomyces cerevisiae YHR072W-A NOP10 ZYRO0D10230g highly similar to uniprot|P69851 Saccharomyces cerevisiae YDR320C-A DAD4 Essential protein component of the DASH complex ZYRO0D10252g similar to uniprot|Q759H7 Ashbya gossypii ADR300C ADR300Cp and weakly similar to YHR082C uniprot|P38691 Saccharomyces cerevisiae YHR082C KSP1 Nonessential putative serine/threonine protein kinase of unknown cellular role overproduction causes allele-specific suppression of the prp20-10 mutation ZYRO0D10274g similar to uniprot|P49018 Saccharomyces cerevisiae YDR331W GPI8 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins ZYRO0D10296g similar to uniprot|Q06682 Saccharomyces cerevisiae YDR330W UBX5 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p ZYRO0D10318g similar to uniprot|P38801 Saccharomyces cerevisiae YHR081W LRP1 Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs homolog of mammalian nuclear matrix protein C1D which is involved in regulation of DNA repair and recombination ZYRO0D10340g no similarity ZYRO0D10362g similar to uniprot|P28795 Saccharomyces cerevisiae YDR329C PEX3 peroxisomal membrane protein ZYRO0D10384g similar to uniprot|P52286 Saccharomyces cerevisiae YDR328C SKP1 evolutionarily conserved kinetochore protein that is part of multiple protein complexes ZYRO0D10406g similar to uniprot|Q06681 Saccharomyces cerevisiae YDR326C Hypothetical ORF ZYRO0D10428g weakly similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases ZYRO0D10450g highly similar to uniprot|P89114 Saccharomyces cerevisiae YHR079C-A ZYRO0D10472g similar to uniprot|P32361 Saccharomyces cerevisiae YHR079C IRE1 Serine-threonine kinase and endoribonuclease transmembrane protein that initiates the unfolded protein response signal by regulating synthesis of Hac1p through HAC1 mRNA splicing ZYRO0D10494g similar to uniprot|Q06680 Saccharomyces cerevisiae YDR325W YCG1 Yeast Condensin G ZYRO0D10516g similar to uniprot|Q06679 Saccharomyces cerevisiae YDR324C UTP4 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0D10538g similar to uniprot|P38799 Saccharomyces cerevisiae YHR078W Hypothetical ORF ZYRO0D10560g similar to uniprot|P32609 Saccharomyces cerevisiae YDR323C PEP7 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion which are essential for targeting of vesicles to the endosome required for vacuole inheritance ZYRO0D10582g similar to uniprot|P38798 Saccharomyces cerevisiae YHR077C NMD2 Protein involved in the nonsense-mediated mRNA decay (NMD) pathway interacts with Nam7p and Upf3p ZYRO0D10604g similar to uniprot|P38797 Saccharomyces cerevisiae YHR076W PTC7 Mitochondrially localized type 2C protein phosphatase expression induced by growth on ethanol and by sustained osmotic stress possible role in carbon source utilization in low oxygen environments ZYRO0D10626g similar to uniprot|P81449 Saccharomyces cerevisiae YDR322C-A TIM11 Subunit e of mitochondrial F1F0-ATPase ZYRO0D10648g similar to uniprot|Q06678 Saccharomyces cerevisiae YDR322W MRPL35 Mitochondrial ribosomal protein of the large subunit ZYRO0D10670g weakly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to YHR047C uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase ZYRO0D10692g similar to uniprot|P38796 Saccharomyces cerevisiae YHR075C PPE1 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit also identified as a small subunit mitochondrial ribosomal protein ZYRO0D10714g highly similar to uniprot|P38795 Saccharomyces cerevisiae YHR074W QNS1 Glutamine-dependent NAD() synthetase essential for the formation of NAD() from nicotinic acid adenine dinucleotide ZYRO0D10736g highly similar to uniprot|P38986 Saccharomyces cerevisiae YDR321W ASP1 Cytosolic L-asparaginase involved in asparagine catabolism ZYRO0D10758g similar to uniprot|P38713 Saccharomyces cerevisiae YHR073W OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability ZYRO0D10780g highly similar to uniprot|Q08911 Saccharomyces cerevisiae YOR388C FDH1 NAD()-dependent formate dehydrogenase may protect cells from exogenous formate ZYRO0D10802g similar to uniprot|Q06683 Saccharomyces cerevisiae YDR332W Hypothetical ORF ZYRO0D10824g similar to uniprot|P14693 Saccharomyces cerevisiae YHR083W SAM35 Essential component of the sorting and assembly machinery (SAM complex aka TOB complex) of the mitochondrial outer membrane which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane ZYRO0D10868g similar to uniprot|Q05468 Saccharomyces cerevisiae YDR333C Hypothetical ORF ZYRO0D10890g similar to uniprot|P38803 Saccharomyces cerevisiae YHR085W IPI1 Protein of unknown function essential for viability may be involved in rRNA processing ZYRO0D10912g similar to uniprot|Q08689 Saccharomyces cerevisiae YOR253W NAT5 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing ZYRO0D10934g similar to uniprot|P14906 Saccharomyces cerevisiae YOR254C SEC63 Essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER ZYRO0D10956g similar to uniprot|Q99257 Saccharomyces cerevisiae YPL169C MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export component of the nuclear pore ortholog of human TAP ZYRO0D10978g weakly similar to uniprot|Q08692 Saccharomyces cerevisiae YOR255W OSW1 Protein of unknown function required for the construction of the outer spore wall layers ZYRO0D11000g highly similar to gnl|GLV|CAGL0F03553g Candida glabrata CAGL0F03553g and similar to YPL170W uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme- binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis ZYRO0D11022g similar to uniprot|P32913 Saccharomyces cerevisiae YOR132W VPS17 Peripheral membrane protein required for vacuolar protein sorting ZYRO0D11044g highly similar to uniprot|P32324 Saccharomyces cerevisiae YOR133W EFT1 Elongation factor 2 (EF-2) also encoded by EFT2 catalyzes ribosomal translocation during protein synthesis contains diphthamide the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin or uniprot|P32324 Saccharomyces cerevisiae YDR385W EFT2 Elongation factor 2 (EF-2) ZYRO0D11066g similar to uniprot|Q04149 Saccharomyces cerevisiae YDR386W MUS81 Helix-hairpin-helix protein involved in DNA repair and replication fork stability functions as an endonuclease in complex with Mms4p interacts with Rad54p ZYRO0D11088g similar to uniprot|Q04162 Saccharomyces cerevisiae YDR387C Hypothetical ORF ZYRO0D11110g similar to DEHA0G12903g and some similarites with YDR388W uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 BAR adaptor protein subunit of a complex (Rvs161p-Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress ZYRO0D11132g some similarities with uniprot|P17121 Saccharomyces cerevisiae YDR389W SAC7 GTPase activating protein (GAP) for Rho1p involved in signaling to the actin cytoskeleton null mutations suppress tor2 mutations and temperature sensitive mutations in actin potential Cdc28p substrate and some similarities with uniprot|Q12128 Saccharomyces cerevisiae YOR134W BAG7 Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p ZYRO0D11154g similar to uniprot|P52488 Saccharomyces cerevisiae YDR390C UBA2 Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability ZYRO0D11220g highly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD()-dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle ZYRO0D11242g some similarities with uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Contains three calcium and lipid binding domains localized to the bud green fluorescent protein (GFP)-fusion protein localizes to the cell periphery mRNA is targeted to the bud via the mRNA transport system involving She2p C-terminal portion of Tcb1p Tcb2p and Tcb3p interact ZYRO0D11264g similar to uniprot|Q12242 Saccharomyces cerevisiae YOR138C RUP1 ZYRO0D11286g some similarities with uniprot|P20134 Saccharomyces cerevisiae YOR140W SFL1 Transcription factor with domains homologous to Hsf1p and to myc oncoprotein required for normal cell surface assembly and flocculence ZYRO0D11308g similar to uniprot|Q12386 Saccharomyces cerevisiae YOR141C ARP8 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes ZYRO0D11352g highly similar to gnl|GLV|CAGL0I07139g Candida glabrata CAGL0I07139g and similar to YOR142W uniprot|P53598 Saccharomyces cerevisiae YOR142W LSC1 Alpha subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide- dependent conversion of succinyl-CoA to succinate ZYRO0D11374g similar to uniprot|P35202 YOR143C Saccharomyces cerevisiae THI80 Thiamine pyrophosphokinase ZYRO0D11396g highly similar to uniprot|P06844 YDR392W Saccharomyces cerevisiae SPT3 Subunit of the SAGA and SAGA-like transcriptional regulatory complexes ZYRO0D11418g similar to uniprot|Q12050 Saccharomyces cerevisiae YOR144C ELG1 Protein required for S phase progression and telomere homeostasis ZYRO0D11440g highly similar to uniprot|Q7LHP7 Saccharomyces cerevisiae YOR145C PNO1 Partner of Nob1 Protein required for cell viability ZYRO0D11462g similar to uniprot|Q12171 Saccharomyces cerevisiae YOR147W MDM32 Mitochondrial Distribution and Morphology ZYRO0D11484g some similarities with uniprot|Q02521 Saccharomyces cerevisiae YOR148C SPP2 ZYRO0D11506g similar to gnl|GLV|CAGL0M01518g Candida glabrata CAGL0M01518g and some similarites with Q04172 YDR393W uniprot|Q04172 Saccharomyces cerevisiae SHE9 Mitochondrial inner membrane protein required for normal mitochondrial morphology ZYRO0D11528g highly similar to uniprot|P33298 Saccharomyces cerevisiae YDR394W RPT3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates substrate of N-acetyltransferase B ZYRO0D11550g similar to uniprot|Q04174 Saccharomyces cerevisiae YOR149C SMP3 Protein involved in glycosyl phosphatidyl inositol synthesis most likely an alpha 1 2 mannosyltransferase utilized for addition of the fourth side-branching mannose onto the GPI core structure ZYRO0D11572g similar to uniprot|Q04175 Saccharomyces cerevisiae YDR395W SXM1 Nuclear protein; has similarity to Cse1p homologs including Nmd5p, Cse1p,Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; also has similarity to the karyopherin Kap95p ZYRO0D11594g highly similar to uniprot|Q04176 Saccharomyces cerevisiae YDR397C NCB2 Beta subunit of the NC2 dimeric histone-fold complex represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2) ZYRO0D11616g similar to uniprot|Q04177 Saccharomyces cerevisiae YDR398W UTP5 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0D11638g highly similar to uniprot|Q04178 Saccharomyces cerevisiae YDR399W HPT1 Dimeric hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of both inosine monophosphate and guanosine monophosphate mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome ZYRO0D11660g similar to uniprot|Q04179 YDR400W Saccharomyces cerevisiae URH1 uridine nucleosidase (uridine ribohydrolase) ZYRO0D11682g similar to uniprot|P21595 Saccharomyces cerevisiae YDR402C DIT2 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall homologous to cytochrome P-450s ZYRO0D11704g similar to uniprot|P21623 YDR403W Saccharomyces cerevisiae DIT1 Sporulation-specific enzyme required for spore wall maturation ZYRO0D11726g highly similar to uniprot|P34087 Saccharomyces cerevisiae YDR404C RPB7 RNA polymerase II subunit B16 forms two subunit dissociable complex with Rpb4p ZYRO0D11748g highly similar to uniprot|Q12487 Saccharomyces cerevisiae YOR150W MRPL23 Mitochondrial ribosomal protein of the large subunit ZYRO0D11770g highly similar to uniprot|P08518 Saccharomyces cerevisiae YOR151C RPB2 RNA polymerase II second largest subunit B150, part of central core ZYRO0D11792g similar to uniprot|P32387 Saccharomyces cerevisiae YDR405W MRP20 Mitochondrial ribosomal protein of the large subunit ZYRO0D11814g weakly similar to uniprot|Q99325 Saccharomyces cerevisiae YOR152C Hypothetical ORF ZYRO0D11836g similar to uniprot|Q04182 Saccharomyces cerevisiae YDR406W PDR15 ATP binding cassette (ABC) transporter of the plasma membrane general stress response factor implicated in cellular detoxification target of Pdr1p Pdr3p and Pdr8p transcription regulators promoter contains a PDR responsive element ZYRO0D11858g highly similar to gnl|GLV|CAGL0M01760g Candida glabrata CAGL0M01760g and similar to YOR153W uniprot|P33302 Saccharomyces cerevisiae YOR153W PDR5 Short- lived membrane ABC (ATP-binding cassette) transporter actively exports various drugs expression regulated by Pdr1p also involved in steroid transport cation resistance and cellular detoxification during exponential growth ZYRO0D11880g similar to uniprot|Q04182 Saccharomyces cerevisiae YDR406W PDR15 ATP binding cassette (ABC) transporter of the plasma membrane general stress response factor implicated in cellular detoxification target of Pdr1p Pdr3p and Pdr8p transcription regulators promoter contains a PDR responsive element ZYRO0D11902g highly similar to uniprot|Q99312 Saccharomyces cerevisia YOR155C ISN1 Inosine 5'-monophosphate (IMP)-specific 5'- nucleotidase ZYRO0D11924g similar to uniprot|Q12412 Saccharomyces cerevisiae YOR161C PNS1 ZYRO0D11946g similar to uniprot|Q99189 Saccharomyces cerevisiae YOR160W MTR10 Nuclear import receptor mediates the nuclear localization of proteins involved in mRNA-nucleus export ZYRO0D11968g similar to uniprot|Q12330 YOR159C Saccharomyces cerevisiae SME1 Required for pre-mRNA splicing, cap modification and U1 U2 U4 and U5 snRNA stability ZYRO0D11990g similar to uniprot|P17558 Saccharomyces cerevisiae YOR158W PET123 Mitochondrial ribosomal protein of the small subunit PET123 exhibits genetic interactions with PET122 which encodes a COX3 mRNA-specific translational activator ZYRO0D12012g similar to Q04183 YDR407C uniprot|Q05731 Saccharomyces cerevisiae TRS120 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic ZYRO0D12034g highly similar to uniprot|P25043 YOR157C Saccharomyces cerevisiae PUP1 Endopeptidase with trypsin-like activity that cleaves after basic residues ZYRO0D12056g highly similar to uniprot|P04161 YDR408C Saccharomyces cerevisiae ADE8 Phosphoribosyl-glycinamide transformylase ZYRO0D12078g some similarities with Q04195 YDR409W uniprot|Q7LIJ4 Saccharomyces cerevisiae SIZ1 SUMO ligase that promotes the attachment of sumo (Smt3p small ubiquitin-related modifier) to proteins ZYRO0D12100g similar to uniprot|P32584 Saccharomyces cerevisiae YDR410C STE14 Farnesyl cysteine-carboxyl methyltransferase mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum localizes to the ER membrane ZYRO0D12122g similar to uniprot|Q03433 Saccharomyces cerevisiae YML041C VPS71 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting ZYRO0D12144g similar to uniprot|P32796 YML042W Saccharomyces cerevisiae CAT2 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes ZYRO0D12166g no similarity ZYRO0D12188g similar to uniprot|Q7LIJ5 Saccharomyces cerevisiae YDR411C DFM1 ZYRO0D12210g similar to Q04031 YDR412W uniprot|Q04031 Saccharomyces cerevisiae RRP17 Protein required for cell viability ZYRO0D12232g similar to uniprot|P16151 Saccharomyces cerevisiae YDR414C ERD1 Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins mutants secrete the endogenous ER protein BiP (Kar2p) ZYRO0D12298g similar to uniprot|P32611 YEL050C Saccharomyces cerevisiae RML2 Mitochondrial ribosomal protein of the large subunit ZYRO0D12320g similar to uniprot|Q04033 Saccharomyces cerevisiae YDR415C Hypothetical ORF ZYRO0D12342g highly similar to uniprot|P32610 YEL051W Saccharomyces cerevisiae VMA8 vacuolar ATPase V1 domain subunit D ZYRO0D12364g similar to Q12309 YDR416W uniprot|Q04048 Saccharomyces cerevisiae CLF1 sssential splicesome assembly factor ZYRO0D12386g similar to uniprot|P32317 YEL052W Saccharomyces cerevisiae AFG1 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to mitochondria ZYRO0D12408g similar to uniprot|Q02197 Saccharomyces cerevisiae YEL053C MAK10 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type ZYRO0D12430g highly similar to uniprot|P17079 YEL054C Saccharomyces cerevisiae RPL12A Protein component of the large (60S) ribosomal subunit ZYRO0D12452g similar to Q04049 YDR419W uniprot|Q04049 Saccharomyces cerevisiae RAD30 DNA polymerase eta involved in the predominantly error-free bypass replication of DNA lesions ZYRO0D12496g some similarities with uniprot|P41809 Saccharomyces cerevisiae YDR420W HKR1 Serine/threonine rich cell surface protein that contains an EF hand motif involved in the regulation of cell wall beta-1 3 glucan synthesis and bud site selection overexpression confers resistance to Hansenula mrakii killer toxin HM-1 ZYRO0D12518g similar to uniprot|Q04052 Saccharomyces cerevisiae YDR421W ARO80 Zinc finger transcriptional activator of the Zn2Cys6 family activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids ZYRO0D12540g some similarities with uniprot|Q04233 Saccharomyces cerevisiae YML006C GIS4 CAAX box containing protein of unknown function proposed to be involved in the RAS/cAMP signaling pathway ZYRO0D12562g some similarities with uniprot|P32578 Saccharomyces cerevisiae YDR422C SIP1 Alternate beta-subunit of the Snf1p kinase complex may confer substrate specificity vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions ZYRO0D12584g weakly similar to uniprot|P19880 YML007W Saccharomyces cerevisiae YAP1 bZip transcription factor required for oxidative stress tolerance ZYRO0D12606g highly similar to uniprot|P25087 YML008C Saccharomyces cerevisiae ERG6 Delta(24)-sterol C-methyltransferase ZYRO0D12628g similar to gnl|GLV|CAGL0A01243g Candida glabrata CAGL0A01243g and weakly similar to uniprot|P25346 YCR098C Saccharomyces cerevisiae GIT1 Plasma membrane permease mediates uptake of the phosphatidylinositol metabolite ZYRO0D12650g some similarities with uniprot|P28742 Saccharomyces cerevisiae YBL063W KIP1 ZYRO0D12672g similar to uniprot|Q02647 Saccharomyces cerevisiae YDR424C DYN2 Cytoplasmic light chain dynein microtubule motor protein ZYRO0D12694g similar to uniprot|Q04053 Saccharomyces cerevisiae YDR425W SNX41 Sorting nexin that mediates retrieval from endosomes ZYRO0D12716g highly similar to uniprot|Q04062 Saccharomyces cerevisiae YDR427W ZYRO0D12738g similar to uniprot|Q04066 Saccharomyces cerevisiae YDR428C Hypothetical ORF ZYRO0D12782g similar to uniprot|Q04067 YDR429C Saccharomyces cerevisiae TIF35 Subunit of the core complex of translation initiation factor 3(eIF3) ZYRO0D12760g similar to uniprot|P36533 Saccharomyces cerevisiae YML009C MRPL39 Mitochondrial ribosomal protein of the large subunit ZYRO0D12804g similar to uniprot|P27692 YML010W Saccharomyces cerevisiae SPT5 Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation ZYRO0D12826g similar to uniprot|Q04231 Saccharomyces cerevisiae YML011C Hypothetical ORF ZYRO0D12848g highly similar to uniprot|P54837 Saccharomyces cerevisiae YML012W ERV25 Protein that forms a heterotrimeric complex with Erp1 Erp2p and Emp24 member of the p24 family involved in endoplasmic reticulum to Golgi transport ZYRO0D12870g highly similar to uniprot|P32898 YDR430C Saccharomyces cerevisiae CYM1 Cytosolic metalloprotease ZYRO0D12892g weakly similar to uniprot|Q01560 YDR432W Saccharomyces cerevisiae NPL3 RNA-binding protein that carries poly(A) mRNA from the nucleus into the cytoplasm ZYRO0D12914g similar to uniprot|Q04228 YML013W Saccharomyces cerevisiae SEL1 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p ZYRO0D12936g similar to uniprot|P49957 YML014W Saccharomyces cerevisiae TRM9 tRNA methyltransferase ZYRO0D12958g similar to uniprot|Q04080 YDR434W Saccharomyces cerevisiae GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins ZYRO0D12980g similar to uniprot|Q04226 YML015C Saccharomyces cerevisiae TAF11 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation ZYRO0D13002g similar to Q04081 YDR435C uniprot|Q04081 Saccharomyces cerevisiae PPM1 Carboxyl methyl transferase ZYRO0D13024g similar to uniprot|P26570 Saccharomyces cerevisiae YML016C PPZ1 Serine/threonine protein phosphatase Z isoform of Ppz2p involved in regulation of potassium transport ZYRO0D13046g similar to uniprot|Q04082 Saccharomyces cerevisiae YDR437W Protein required for cell viability ZYRO0D13068g some similarities with uniprot|P50109 Saccharomyces cerevisiae YML017W PSP2 Asn rich cytoplasmic protein that contains RGG motifs high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha) possible role in mitochondrial mRNA splicing ZYRO0D13090g similar to uniprot|Q03730 YML018C Saccharomyces cerevisiae Hypothetical ORF ZYRO0D13112g similar to uniprot|Q03723 Saccharomyces cerevisiae YML019W ZYRO0D13134g weakly similar to uniprot|Q04087 Saccharomyces cerevisiae YDR439W LRS4 ZYRO0D13156g similar to uniprot|Q03722 YML020W Saccharomyces cerevisiae Hypothetical ORF ZYRO0D13178g similar to uniprot|P12887 YML021C Saccharomyces cerevisiae UNG1 uracil DNA glycosylase ZYRO0D13200g similar to uniprot|Q04089 YDR440W Saccharomyces cerevisiae DOT1 Nucleosomal histone H3-Lys79 methylase ZYRO0D13222g highly similar to uniprot|P49435 YML022W Saccharomyces cerevisiae APT1 Adenine phosphoribosyltransferase ZYRO0D13244g similar to uniprot|Q03718 Saccharomyces cerevisiae YML023C NSE5 Protein required for cell viability ZYRO0D13266g similar to uniprot|P38931 YDR443C Saccharomyces cerevisiae SSN2 Required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme ZYRO0D13288g highly similar to uniprot|P40581 Saccharomyces cerevisiae YIR037W HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor ZYRO0D13310g similar to uniprot|P43581 Saccharomyces cerevisiae YFL011W HXT10 Putative hexose transporter expressed at low levels and expression is repressed by glucose ZYRO0D13332g similar to uniprot|Q06593 Saccharomyces cerevisiae YPR194C OPT2 Oligopeptide transporter member of the OPT family with potential orthologs in S. pombe and C. albicans ZYRO0D13398g similar to uniprot|Q04093 Saccharomyces cerevisiae YDR444W Hypothetical ORF ZYRO0D13420g similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane ZYRO0D13464g weakly similar to uniprot|Q04110 Saccharomyces cerevisiae YDR446W ECM11 Non-essential protein of unknown function GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis may be involved in maintaining chromatin structure ZYRO0D13486g highly similar to uniprot|P02407 Saccharomyces cerevisiae YML024W RPS17A and to uniprot|P14127 Saccharomyces cerevisiae YDR447C RPS17B Ribosomal proteins 51 (rp51) of the small (40s) subunit ZYRO0D13508g highly similar to uniprot|Q02336 Saccharomyces cerevisiae YDR448W ADA2 Transcription coactivator component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes ZYRO0D13530g highly similar to uniprot|Q02354 Saccharomyces cerevisiae YDR449C UTP6 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0D13552g similar to uniprot|P51998 Saccharomyces cerevisiae YML025C YML6 Mitochondrial ribosomal protein of the large subunit ZYRO0D13574g highly similar to uniprot|P35271 Saccharomyces cerevisiae YML026C RPS18B and highly similar to uniprot|P35271 Saccharomyces cerevisiae YDR450W RPS18A proteins component of the small (40S) ribosomal subunit ZYRO0D13596g similar to uniprot|P34161 Saccharomyces cerevisiae YML027W YOX1 Homeodomain-containing transcriptional repressor binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase expression is cell cycle-regulated potential Cdc28p substrate ZYRO0D13618g similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism functions as a homodimer ZYRO0D13640g highly similar to uniprot|P34760 Saccharomyces cerevisiae YML028W TSA1 and to uniprot|Q04120 Saccharomyces cerevisiae YDR453C TSA2 Thioredoxin- peroxidase ZYRO0D13662g some similarities with uniprot|Q03714 Saccharomyces cerevisiae YML029W USA1 Protein that interacts in the two-hybrid system with the U1 snRNP-specific protein Snp1p may have a role in pre-mRNA splicing ZYRO0D13684g similar to uniprot|Q03713 Saccharomyces cerevisiae YML030W ZYRO0D13706g highly similar to uniprot|P15454 Saccharomyces cerevisiae YDR454C GUK1 Guanylate kinase converts GMP to GDP required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins ZYRO0D13728g similar to uniprot|Q04121 Saccharomyces cerevisiae YDR456W NHX1 Endosomal Na+/H+ exchanger ZYRO0D13750g similar to uniprot|P32500 Saccharomyces cerevisiae YML031W NDC1 Nuclear envelope protein with multiple putative transmembrane domains ZYRO0D13772g similar to uniprot|P06778 Saccharomyces cerevisiae YML032C RAD52 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA anneals complementary single-stranded DNA involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis ZYRO0D13794g similar to uniprot|Q7LIK7 Saccharomyces cerevisiae YDR457W TOM1 Temperature dependent Organization in Mitotic nucleus ZYRO0D13816g some similarities with uniprot|Q03707 Saccharomyces cerevisiae YML034W SRC1 and uniprot|Q03281 Saccharomyces cerevisiae YDR458C ZYRO0D13838g similar to uniprot|P15274 Saccharomyces cerevisiae YML035C AMD1 AMP deaminase tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia may be involved in regulation of intracellular adenine nucleotide pools ZYRO0D13860g similar to uniprot|Q03289 Saccharomyces cerevisiae YDR459C likely functions in pathway(s) outside Ras ZYRO0D13882g highly similar to uniprot|P89104 Saccharomyces cerevisiae YDR460W ZYRO0D13904g similar to uniprot|Q03705 Saccharomyces cerevisiae YML036W Hypothetical ORF ZYRO0D13926g weakly similar to uniprot|Q03703 Saccharomyces cerevisiae YML037C Hypothetical ORF ZYRO0D13948g similar to uniprot|P36527 Saccharomyces cerevisiae YDR462W MRPL28 Mitochondrial ribosomal protein of the large subunit ZYRO0D13970g similar to uniprot|Q03697 Saccharomyces cerevisiae YML038C YMD8 ZYRO0D13992g similar to uniprot|Q00947 Saccharomyces cerevisiae YDR463W STP1 and uniprot|P38704 Saccharomyces cerevisiae YHR006W STP2 Transcription factor ZYRO0D14014g some similarities with uniprot|P38904 Saccharomyces cerevisiae YDR464W SPP41 appears to control expression of spliceosome components PRP4 and PRP3 negative regulator of prp genes ZYRO0D14036g highly similar to uniprot|P10614 Saccharomyces cerevisiae YHR007C ERG11 Lanosterol 14-alpha-demethylase catalyzes the C-14 demethylation of lanosterol to form 4 4''-dimethyl cholesta-8 14 24-triene-3-beta-ol in the ergosterol biosynthesis pathway member of the cytochrome P450 family ZYRO0D14058g similar to uniprot|Q6B2M3 Saccharomyces cerevisiae YOR172W and similar to uniprot|Q06149 Saccharomyces cerevisiae YLR266C PDR8 ZYRO0D14080g weakly similar to uniprot|Q12172 Saccharomyces cerevisiae YOR162C YRR1 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance paralog of Yrm1p acting on an overlapping set of target genes ZYRO0D14102g uniprot|Q9UUT4 Zygosaccharomyces rouxii sod2 Na /H antiporter ZYRO0D14146g highly similar to uniprot|Q6Q5L1 Saccharomyces cerevisiae YLR270W DCS1 Non-essential hydrolase involved in mRNA decapping may function in a feedback mechanism to regulate deadenylation contains pyrophosphatase activity and a HIT (histidine triad) motif interacts with neutral trehalase Nth1p ZYRO0D14168g weakly similar to uniprot|Q06152 Saccharomyces cerevisiae YLR271W Hypothetical ORF ZYRO0D14190g similar to uniprot|Q12343 Saccharomyces cerevisiae YOR174W MED4 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex ZYRO0D14212g similar to uniprot|Q03130 Saccharomyces cerevisiae YOR175C Hypothetical ORF ZYRO0D14234g highly similar to uniprot|P16622 Saccharomyces cerevisiae YOR176W HEM15 Ferrochelatase a mitochondrial inner membrane protein catalyzes the insertion of ferrous iron into protoporphyrin IX the eighth and final step in the heme biosynthetic pathway Yfh1p mediates the use of iron by Hem15p ZYRO0D14256g similar to uniprot|Q06156 Saccharomyces cerevisiae YLR272C YCS4 Protein required for accurate sister chromatid segregation ZYRO0D14322g weakly similar to uniprot|P28006 Saccharomyces cerevisiae YOR178C GAC1 Regulatory subunit for Glc7p (protein phosphatase I) for glycogen synthesis regulatory role also predicted for glucose repression and ion homeostasis potential Cdc28p substrate ZYRO0D14344g highly similar to uniprot|P29496 Saccharomyces cerevisiae YLR274W CDC46 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase ZYRO0D14366g highly similar to uniprot|Q06217 Saccharomyces cerevisiae YLR275W SMD2 U1 snRNP protein of the Sm class ZYRO0D14388g highly similar to uniprot|Q06218 Saccharomyces cerevisiae YLR276C DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit ZYRO0D14410g highly similar to uniprot|Q06224 Saccharomyces cerevisiae YLR277C YSH1 subunit of Polyadenylation factor I (PF I) ZYRO0D14432g similar to uniprot|Q05854 Saccharomyces cerevisiae YLR278C Protein of unknown function localizes to the nucleus potential Cdc28p substrate ZYRO0D14454g similar to uniprot|Q08558 Saccharomyces cerevisiae YOR180C DCI1 Peroxisomal delta(3 5)-delta(2 4)-dienoyl-CoA isomerase involved in fatty acid metabolism contains peroxisome targeting signals at amino and carboxy termini ZYRO0D14476g similar to uniprot|Q05863 Saccharomyces cerevisiae YLR281C Hypothetical ORF ZYRO0D14498g similar to uniprot|Q05867 Saccharomyces cerevisiae YLR283W Hypothetical ORF ZYRO0D14520g similar to uniprot|Q05871 Saccharomyces cerevisiae YLR284C ECI1 Peroxisomal delta3 delta2-enoyl-CoA isomerase hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA essential for the beta-oxidation of unsaturated fatty acids oleate-induced ZYRO0D14542g similar to uniprot|Q05874 Saccharomyces cerevisiae YLR285W NNT1 Putative nicotinamide N-methyltransferase has a role in rDNA silencing and in lifespan determination ZYRO0D14564g similar to uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase required for cell separation after mitosis transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p ZYRO0D14586g similar to uniprot|Q12446 Saccharomyces cerevisiae YOR181W LAS17 Actin assembly factor activates the Arp2/3 protein complex that nucleates branched actin filaments localizes with the Arp2/3 complex to actin patches homolog of the human Wiskott-Aldrich syndrome protein (WASP) ZYRO0D14608g similar to gnl|GLV|CAGL0M09757g Candida glabrata CAGL0M09757g and weakly similar to YLR287C uniprot|Q05881 Saccharomyces cerevisiae YLR287C Hypothetical ORF ZYRO0D14630g highly similar to uniprot|Q12087 Saccharomyces cerevisiae YOR182C RPS30B ZYRO0D14652g highly similar to uniprot|P33330 Saccharomyces cerevisiae YOR184W SER1 phosphoserine transaminase ZYRO0D14674g similar to uniprot|Q02574 Saccharomyces cerevisiae YLR288C MEC3 Involved in checkpoint control and DNA repair forms a clamp with Rad17p and Ddc1p that is loaded onto partial duplex DNA DNA damage checkpoint protein ZYRO0D14696g highly similar to uniprot|P46943 Saccharomyces cerevisiae YLR289W GUF1 Mitochondrial GTPase of unknown function ZYRO0D14718g similar to uniprot|Q05892 Saccharomyces cerevisiae YLR290C Hypothetical ORF ZYRO0D14740g highly similar to uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression ZYRO0D14762g similar to uniprot|P39742 Saccharomyces cerevisiae YLR292C SEC72 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER ZYRO0D14784g highly similar to uniprot|P32836 Saccharomyces cerevisiae YOR185C GSP2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization RNA processing and transport interacts with Kap121p Kap123p and Pdr6p (karyophilin betas) Gsp1p homolog that is not required for viability ZYRO0D14828g conserved hypothetical protein ZYRO0D14850g similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis ZYRO0D14872g some similarities with uniprot|Q05899 Saccharomyces cerevisiae YLR297W Hypothetical ORF ZYRO0D14894g similar to uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 U1 snRNP protein required for pre-mRNA splicing ZYRO0D14916g highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities while these activities are found in separate proteins in S. pombe and humans ZYRO0D14938g similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase major glutathione-degrading enzyme expression induced mainly by nitrogen starvation ZYRO0D14960g some similarities with uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1 3-beta-glucan synthesis and the Pkc1p-MAPK pathway potential Cdc28p substrate multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42 and of mutations in BEM4 ZYRO0D14982g some similarities with uniprot|Q08561 Saccharomyces cerevisiae YOR189W IES4 ZYRO0D15004g similar to uniprot|P23776 Saccharomyces cerevisiae YLR300W EXG1 Major exo-1 3-beta-glucanase of the cell wall involved in cell wall beta-glucan assembly exists as three differentially glycosylated isoenzymes ZYRO0D15026g similar to uniprot|Q08562 Saccharomyces cerevisiae YOR191W RIS1 Member of the SWI/SNF family of DNA-dependent ATPases plays a role in antagonizing silencing during mating-type switching contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain ZYRO0D15048g similar to uniprot|Q05905 Saccharomyces cerevisiae YLR301W Hypothetical ORF ZYRO0D15092g similar to uniprot|P40566 Saccharomyces cerevisiae YIR007W Hypothetical ORF ZYRO0D15114g highly similar to uniprot|P10363 Saccharomyces cerevisiae YIR008C PRI1 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair ZYRO0D15136g similar to uniprot|P15992 Saccharomyces cerevisiae YBR072W HSP26 Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer induced by heat upon entry into stationary phase and during sporulation ZYRO0D15158g highly similar to uniprot|P22141 Saccharomyces cerevisiae YER012W PRE1 20S proteasome beta-type subunit localizes to the nucleus throughout the cell cycle ZYRO0D15180g similar to uniprot|P24384 Saccharomyces cerevisiae YER013W PRP22 RNA-dependent ATPase/ATP-dependent RNA helicase in the DEAH-box family associates with the lariat intermediate before the second catalytic step of splicing ZYRO0D15202g similar to uniprot|P40012 Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway converting protoporphyrinogen IX to protoporphyrin IX ZYRO0D15224g weakly similar to uniprot|P40567 Saccharomyces cerevisiae YIR009W MSL1 U2B component of U2 snRNP involved in splicing binds the U2 snRNA stem-loop IV in vitro does not contain the conserved C-terminal RNA binding domain found in other family members ZYRO0D15246g similar to uniprot|P39518 Saccharomyces cerevisiae YER015W FAA2 Long chain fatty acyl-CoA synthetase accepts a wider range of acyl chain lengths than Faa1p preferring C9:0-C13:0 involved in the activation of endogenous pools of fatty acids ZYRO0D15268g similar to uniprot|P40013 Saccharomyces cerevisiae YER016W BIM1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally ZYRO0D15290g similar to uniprot|P39925 Saccharomyces cerevisiae YER017C AFG3 Component with Yta12p of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes ZYRO0D15312g similar to uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes contains an HMG domain that is responsible for DNA bending activity ZYRO0D15334g highly similar to uniprot|P33759 Saccharomyces cerevisiae YBR251W MRPS5 Mitochondrial ribosomal protein of the small subunit ZYRO0D15356g similar to YBR252W, uniprot|P33317 Saccharomyces cerevisiae YBR252W (DUT1) ZYRO0D15378g similar to uniprot|P32570 Saccharomyces cerevisiae YBR253W SRB6 Protein involved in transcription as part of the Srb/Mediator complex ZYRO0D15400g some similarities with uniprot|P40568 Saccharomyces cerevisiae YIR010W DSN1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules important for chromosome segregation ZYRO0D15422g similar to uniprot|P38334 Saccharomyces cerevisiae YBR254C TRS20 Trapp subunit of 20 kDa probable membrane protein mutations in the human homolog cause spondyloepiphyseal dysplasia tarda (SEDL) a genetically heterogeneous disorder characterized by short stature and early-onset osteoarthritis ZYRO0D15444g weakly similar to uniprot|P38335 Saccharomyces cerevisiae YBR255W Protein of unknown function required for normal growth rate at 15 degrees C green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0D15466g similar to uniprot|Q3E776 Saccharomyces cerevisiae YBR255C-A Hypothetical ORF identified by homology ZYRO0D15488g similar to uniprot|P38637 Saccharomyces cerevisiae YIR011C STS1 Protein that interacts with the karyopherin Srp1p may have a role with Srp1p in ubiquitin-mediated protein degradation ZYRO0D15510g similar to uniprot|P35184 Saccharomyces cerevisiae YIR012W SQT1 Protein involved in a late step of 60S ribosomal subunit assembly or modification contains multiple WD repeats interacts with Qsr1p in the two-hybrid system ZYRO0D15532g highly similar to uniprot|P38145 Saccharomyces cerevisiae YBR256C RIB5 Riboflavin synthase catalyzes the last step of the riboflavin biosynthesis pathway ZYRO0D15554g weakly similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. ZYRO0D15576g some similarities with uniprot|P40548 Saccharomyces cerevisiae YIL016W SNL1 Integral membrane protein containing a Bag domain suppressor of nup116-C lethal ZYRO0D15598g similar to uniprot|P40547 Saccharomyces cerevisiae YIL017C VID28 Vacuole import and degradation ZYRO0D15620g similar to uniprot|P39692 Saccharomyces cerevisiae YFR030W MET10 Subunit alpha of assimilatory sulfite reductase which is responsible for the conversion of sulfite into sulfide ZYRO0D15642g similar to uniprot|P38989 Saccharomyces cerevisiae YFR031C SMC2 Component of the condensin complex essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase Smc2p/Smc4p complex binds DNA possibly in the cleft formed by the coiled-coil of the folded dimer ZYRO0D15664g highly similar to uniprot|P05736 Saccharomyces cerevisiae YIL018W RPL2B and highly similar to uniprot|P05736 Saccharomyces cerevisiae YFR031C-A RPL2A, Protein component of the large (60S) ribosomal subunit ZYRO0D15686g some similarities with uniprot|P43607 Saccharomyces cerevisiae YFR032C Hypothetical ORF ZYRO0D15708g weakly similar to uniprot|P00127 Saccharomyces cerevisiae YFR033C QCR6 ubiquinol-cytochrome c oxidoreductase subunit 6 (17 kDa) ZYRO0D15730g conserved hypothetical protein ZYRO0D15752g similar to uniprot|P40546 Saccharomyces cerevisiae YIL019W FAF1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly ZYRO0D15774g highly similar to uniprot|P40545 Saccharomyces cerevisiae YIL020C HIS6 Phosphoribosyl-5-amino-1-phosphoribosyl-4- imidazolecarboxiamide isomerase catalyzes the fourth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts ZYRO0D15796g highly similar to uniprot|P16370 Saccharomyces cerevisiae YIL021W ZYRO0D15818g conserved hypothetical protein ZYRO0D15840g highly similar to uniprot|Q01852 Saccharomyces cerevisiae YIL022W TIM44 48.8 kDa protein involved in mitochondrial protein import ZYRO0D15862g similar to uniprot|P40537 Saccharomyces cerevisiae YIL031W ULP2 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects potential Cdc28p substrate ZYRO0D15884g similar to uniprot|P40318 Saccharomyces cerevisiae YIL030C SSM4 Protein involved in mRNA turnover integral nuclear membrane protein ZYRO0D15906g no similarity ZYRO0D15950g weakly similar to uniprot|P14724 Saccharomyces cerevisiae YFR036W ZYRO0D15972g similar to uniprot|P40540 Saccharomyces cerevisiae YIL027C KRE27 Protein of unknown function null mutant shows K1 killer toxin resistance ZYRO0D15994g similar to uniprot|P40541 Saccharomyces cerevisiae YIL026C IRR1 Subunit of the cohesin complex which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms essential for viability ZYRO0D16016g similar to uniprot|P40543 Saccharomyces cerevisiae YIL024C Hypothetical ORF ZYRO0D16038g similar to uniprot|P40544 Saccharomyces cerevisiae YIL023C Hypothetical ORF ZYRO0D16060g similar to uniprot|P43609 Saccharomyces cerevisiae YFR037C RSC8 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex essential for viability and mitotic growth homolog of SWI/SNF subunit Swi3p but unlike Swi3p does not activate transcription of reporters ZYRO0D16082g similar to uniprot|P43610 Saccharomyces cerevisiae YFR038W Hypothetical ORF ZYRO0D16104g similar to uniprot|P07278 YIL033C Saccharomyces cerevisiae BCY1 Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) ZYRO0D16126g highly similar to uniprot|P40030 Saccharomyces cerevisiae YER044C ERG28 Endoplasmic reticulum membrane protein may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3- ketoreductase and/or tether these enzymes to the ER also interacts with Erg6p ZYRO0D16148g similar to uniprot|P13517 Saccharomyces cerevisiae YIL034C CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches ZYRO0D16170g highly similar to uniprot|P15790 Saccharomyces cerevisiae YIL035C CKA1 alpha subunit of protein kinase CK2 ZYRO0D16192g weakly similar to uniprot|P29467 Saccharomyces cerevisiae YER044C-A MEI4 Functions in early recombination mRNA is meiosis-specific and has 88 bp intron at 5' end spliced independently of MER1. ZYRO0D16214g some similarities with uniprot|P40535 Saccharomyces cerevisiae YIL036W CST6 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family activates transcription of genes involved in utilization of non-optimal carbon sources ZYRO0D16236g some similarities with uniprot|P38079 Saccharomyces cerevisiae YBR054W YRO2 Putative plasma membrane protein of unknown function transcriptionally regulated by Haa1p green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud ZYRO0D16258g similar to uniprot|P40031 Saccharomyces cerevisiae YER046W SPO73 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensible for both nuclear divisions during meiosis ZYRO0D16280g conserved hypothetical protein ZYRO0D16302g similar to uniprot|P06102 Saccharomyces cerevisiae YIL038C NOT3 Subunit of the CCR4-NOT complex which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation ZYRO0D16324g conserved hypothetical protein ZYRO0D16346g some similarities with uniprot|P39955 Saccharomyces cerevisiae YER047C SAP1 Putative ATPase of the AAA family interacts with the Sin1p transcriptional repressor in the two-hybrid system ZYRO0D16368g similar to uniprot|P40533 Saccharomyces cerevisiae YIL039W Hypothetical ORF ZYRO0D16390g similar to uniprot|P39101 YER048C Saccharomyces cerevisiae CAJ1 Nuclear type II J heat shock protein of the E. coli dnaJ family ZYRO0D16412g weakly similar to uniprot|P40532 Saccharomyces cerevisiae YIL040W APQ12 Protein involved in nucleocytoplasmic transport of mRNA ZYRO0D16478g similar to uniprot|Q6Q560 Saccharomyces cerevisiae YER048W-A ZYRO0D16500g similar to uniprot|P40032 Saccharomyces cerevisiae YER049W Hypothetical ORF ZYRO0D16522g similar to uniprot|P40531 Saccharomyces cerevisiae YIL041W GVP36 Golgi-vesicle protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm ZYRO0D16544g similar to uniprot|P40530 Saccharomyces cerevisiae YIL042C Hypothetical ORF ZYRO0D16566g similar to gnl|GLV|KLLA0E04477g Kluyveromyces lactis KLLA0E04477g and some similarites with YER050C uniprot|P40033 Saccharomyces cerevisiae ZYRO0D16588g similar to uniprot|P40034 Saccharomyces cerevisiae YER051W Hypothetical ORF ZYRO0D16610g similar to uniprot|P38626 Saccharomyces cerevisiae YIL043C CBR1 cytochrome b reductase ZYRO0D16632g highly similar to uniprot|P10869 Saccharomyces cerevisiae YER052C HOM3 Aspartate kinase (L-aspartate 4-P-transferase) cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis ZYRO0D16654g conserved hypothetical protein ZYRO0D16676g similar to uniprot|P40529 Saccharomyces cerevisiae YIL044C AGE2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector ARF GAP with effector function(s) ZYRO0D16698g highly similar to uniprot|P40035 Saccharomyces cerevisiae YER053C PIC2 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Mir1p but less abundant than Mir1p under normal conditions expression is induced at high temperature ZYRO0D16720g some similarities with uniprot|P40036 Saccharomyces cerevisiae YER054C GIP2 Putative regulatory subunit of the protein phosphatase Glc7p proposed to be involved in glycogen metabolism contains a conserved motif (GVNK motif) that is also found in Gac1p Pig1p and Pig2p ZYRO0D16742g similar to uniprot|P39014 Saccharomyces cerevisiae YIL046W MET30 F-box protein containing five copies of the WD40 motif controls cell cycle function sulfur metabolism and methionine biosynthesis as part of the ubiquitin ligase complex interacts with and regulates Met4p localizes within the nucleus ZYRO0D16764g highly similar to uniprot|P00498 Saccharomyces cerevisiae YER055C HIS1 ATP phosphoribosyltransferase a hexameric enzyme catalyzes the first step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control ZYRO0D16786g similar to uniprot|P40528 Saccharomyces cerevisiae YIL047C SYG1 Protein for which truncation and overexpression can suppress lethality of G-alpha protein deficiency plasma membrane protein ZYRO0D16830g highly similar to uniprot|P40527 Saccharomyces cerevisiae YIL048W NEO1 Protein involved in the retrograde transport from the Golgi complex to the ER and the endosomal membrane traffic putative aminophospholipid translocase member of the highly conserved Drs2 family of P-type ATPases ZYRO0D16852g similar to uniprot|P40526 Saccharomyces cerevisiae YIL049W DFG10 Protein of unknown function involved in filamentous growth ZYRO0D16874g similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 Purine-cytosine permease mediates purine (adenine guanine and hypoxanthine) and cytosine accumulation ZYRO0D16896g highly similar to uniprot|P40525 Saccharomyces cerevisiae YIL052C RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein ZYRO0D16918g no similarity ZYRO0D16940g similar to uniprot|P46989 Saccharomyces cerevisiae YJL178C ATG27 Type II membrane protein that binds phosphatidylinositol 3-phosphate required for the cytoplasm-to-vacuole targeting (Cvt) pathway ZYRO0D16962g highly similar to uniprot|P46988 Saccharomyces cerevisiae YJL179W PFD1 Subunit of heterohexameric prefoldin which binds cytosolic chaperonin and transfers target proteins to it involved in the biogenesis of actin and of alpha- and gamma-tubulin ZYRO0D16984g similar to uniprot|P22135 Saccharomyces cerevisiae YJL180C ATP12 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase ZYRO0D17006g weakly similar to uniprot|P47101 Saccharomyces cerevisiae YJR030C Hypothetical ORF ZYRO0D17028g similar to uniprot|P46985 Saccharomyces cerevisiae YJL183W MNN11 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p Mnn9p Mnn10p and Hoc1p and mediates elongation of the polysaccharide mannan backbone has homology to Mnn10p ZYRO0D17050g similar to uniprot|P25621 Saccharomyces cerevisiae YCR028C FEN2 Plasma membrane H -pantothenate symporter confers sensitivity to the antifungal agent fenpropimorph ZYRO0D17072g similar to uniprot|P46984 Saccharomyces cerevisiae YJL184W GON7 Protein of unknown function proposed to be involved in the transfer of mannosylphosphate groups onto N-linked oligosaccharides also proposed to be involved in responding to osmotic stress ZYRO0D17094g highly similar to gnl|GLV|CAGL0L08068g Candida glabrata CAGL0L08068g and similar to YCR028C-A uniprot|P32445 Saccharomyces cerevisiae YCR028C-A RIM1 Single-stranded DNA-binding protein that is essential for mitochondrial genome maintenance Single-stranded zinc finger DNA-binding protein ZYRO0D17116g weakly similar to uniprot|P46983 Saccharomyces cerevisiae YJL185C Hypothetical ORF ZYRO0D17138g similar to uniprot|P25623 Saccharomyces cerevisiae YCR030C SYP1 Protein with a potential role in actin cytoskeletal organization overexpression suppresses a pfy1 (profilin) null mutation ZYRO0D17160g similar to uniprot|P46982 Saccharomyces cerevisiae YJL186W MNN5 Alpha-1 2-mannosyltransferase responsible for addition of the second alpha-1 2-linked mannose of the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment ZYRO0D17182g similar to uniprot|P25649 Saccharomyces cerevisiae YCR082W AHC2 component of the yeast ADA acetyltransferase complex ZYRO0D17204g similar to uniprot|P25372 Saccharomyces cerevisiae YCR083W TRX3 mitochondrial thioredoxin ZYRO0D17226g similar to uniprot|P53736 Saccharomyces cerevisiae YNR040W Hypothetical ORF ZYRO0D17248g similar to uniprot|P32378 Saccharomyces cerevisiae YNR041C COQ2 Para hydroxybenzoate: polyprenyl transferase catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis ZYRO0D17270g similar to uniprot|P32377 Saccharomyces cerevisiae YNR043W MVD1 Mevalonate pyrophosphate decarboxylase essential enzyme involved in the biosynthesis of isoprenoids and sterols including ergosterol acts as a homodimer ZYRO0D17292g some similarities with uniprot|P16649 Saccharomyces cerevisiae YCR084C ZYRO0D17314g similar to uniprot|P25651 Saccharomyces cerevisiae YCR086W CSM1 Protein that forms a complex with Lrs4p located in the nucleolus Lrs4p-Csm1p heterodimer binds to Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation may be involved in premeiotic DNA replication ZYRO0D17336g some similarities with uniprot|P37263 Saccharomyces cerevisiae YCR087C-A Hypothetical ORF ZYRO0D17358g similar to uniprot|P15891 Saccharomyces cerevisiae YCR088W ABP1 Actin-binding protein of the cortical actin cytoskeleton important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization ZYRO0D17380g no similarity ZYRO0D17402g similar to uniprot|P25654 Saccharomyces cerevisiae YCR090C Hypothetical ORF ZYRO0D17424g weakly similar to uniprot|P07390 Saccharomyces cerevisiae YNR045W PET494 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p located in the mitochondrial inner membrane ZYRO0D17446g highly similar to uniprot|P53738 YNR046W Saccharomyces cerevisiae TRM112 Protein required for cell viability ZYRO0D17468g weakly similar to uniprot|P53739 Saccharomyces cerevisiae YNR047W Putative protein kinase that when overexpressed interferes with pheromone-induced growth arrest localizes to the cytoplasm potential Cdc28p substrate and some similarities with YCR091W uniprot|P25341 Saccharomyces cerevisiae YCR091W KIN82 Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily ZYRO0D17490g similar to uniprot|P25336 Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends contains a PCNA (Pol30p) binding motif required for genome stability ZYRO0D17512g some similarities with uniprot|P25655 YCR093W Saccharomyces cerevisiae CDC39 Component of the CCR4-NOT complex regulating mRNA levels ZYRO0D17534g similar to uniprot|P25656 Saccharomyces cerevisiae YCR094W CDC50 Endosomal protein that regulates cell polarity ZYRO0D17556g similar to uniprot|P53604 Saccharomyces cerevisiae YNR049C MSO1 Probable component of the secretory vesicle docking complex acts at a late step in secretion shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions required for sporulation ZYRO0D17578g highly similar to uniprot|P38999 YNR050C Saccharomyces cerevisiae LYS9 Saccharopine dehydrogenase (NADP L- glutamate-forming) ZYRO0D17600g similar to uniprot|P25366 Saccharomyces cerevisiae YCR095C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts ZYRO0D17622g some similarities with uniprot|P53741 YNR051C Saccharomyces cerevisiae BRE5 Ubiquitin protease cofactor ZYRO0D17644g similar to uniprot|P39008 YNR052C Saccharomyces cerevisiae POP2 RNase of the DEDD superfamily subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation ZYRO0D17666g similar to gnl|GLV|DEHA0E02046g Debaryomyces hansenii DEHA0E02046g and some similarites with YNR053C uniprot|P53742 Saccharomyces cerevisiae YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation ZYRO0D17688g similar to uniprot|P53743 YNR054C Saccharomyces cerevisiae ESF2 Essential nucleolar protein involved in pre-18S rRNA processing ZYRO0D17710g highly similar to uniprot|P33302 Saccharomyces cerevisiae YOR153W PDR5 Short-lived membrane ABC (ATP-binding cassette) transporter actively exports various drugs expression regulated by Pdr1p also involved in steroid transport cation resistance and cellular detoxification during exponential growth ZYRO0D17732g similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane responsible for the majority of zinc uptake transcription is induced under low-zinc conditions by the Zap1p transcription factor ZYRO0D17776g similar to gnl|GLV|KLLA0C18909g Kluyveromyces lactis KLLA0C18909g and weakly similar to YHL016C uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway ZYRO0D17798g some similarities with uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase ZYRO0D17820g conserved hypothetical protein ZYRO0D17842g weakly similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C ZYRO0D17864g some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor ZYRO0D17908g similar to uniprot|P53388 Saccharomyces cerevisiae YPL265W DIP5 Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly ZYRO0D17930g similar to uniprot|P40586 Saccharomyces cerevisiae YIR042C Hypothetical ORF ZYRO0D17952g similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p ZYRO0D17974g weakly similar to uniprot|Q06593 Saccharomyces cerevisiae YPR194C OPT2 Oligopeptide transporter member of the OPT family ZYRO0E00132g weakly similar to uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance interacts with sodium:hydrogen antiporter Nha1p member of a family of conserved often subtelomerically- encoded proteins ZYRO0E00198g similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis ZYRO0E00220g similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase catalyzes the third step in the biotin biosynthesis pathway BIO4 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis expression appears to be repressed at low iron levels ZYRO0E00286g no similarity ZYRO0E00308g no similarity ZYRO0E00330g weakly similar to uniprot|P47187 Saccharomyces cerevisiae YJR161C COS5 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins ZYRO0E00396g conserved hypothetical protein ZYRO0E00418g conserved hypothetical protein ZYRO0E00440g weakly similar to uniprot|P38723 Saccharomyces cerevisiae YHL048W COS8 Nuclear membrane protein member of a family of conserved often subtelomerically-encoded proteins regulation suggests a potential role in the unfolded protein response ZYRO0E00462g similar to uniprot|P36087 Saccharomyces cerevisiae YKL070W Hypothetical ORF ZYRO0E00484g similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 ZYRO0E00528g highly similar to gnl|GLV|KLLA0B03564g Kluyveromyces lactis KLLA0B03564g and similar to YPR191W uniprot|P07257 Saccharomyces cerevisiae YPR191W QCR2 40 kDa ubiquinol cytochrome-c reductase core protein 2 ZYRO0E00550g highly similar to uniprot|P30902 Saccharomyces cerevisiae YKL016C ATP7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis ZYRO0E00572g similar to uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type ZYRO0E00594g similar to uniprot|P34241 Saccharomyces cerevisiae YKL014C URB1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs associated with the 27SA2 pre-ribosomal particle proposed to be involved in the biogenesis of the 60S ribosomal subunit ZYRO0E00616g similar to uniprot|P40576 Saccharomyces cerevisiae YIR024C (putative) involved in cell cycle control ZYRO0E00638g similar to gnl|GLV|CAGL0F06743g Candida glabrata CAGL0F06743g and similar to YIR023W uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism ZYRO0E00660g highly similar to uniprot|P33204 Saccharomyces cerevisiae YKL013C ARC19 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches ZYRO0E00682g similar to uniprot|P33203 Saccharomyces cerevisiae YKL012W PRP40 U1 snRNP protein involved in splicing interacts with the branchpoint-binding protein during the formation of the second commitment complex ZYRO0E00704g highly similar to uniprot|P15367 Saccharomyces cerevisiae YIR022W SEC11 18kDa catalytic subunit of the Signal Peptidase Complex (SPC Spc1p Spc2p Spc3p and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum ZYRO0E00726g weakly similar to uniprot|Q03702 Saccharomyces cerevisiae YKL011C CCE1 cruciform cutting endonuclease ZYRO0E00748g no similarity ZYRO0E00770g similar to gnl|GLV|CAGL0L05302g Candida glabrata CAGL0L05302g and some similarites with YKL088W uniprot|P36076 Saccharomyces cerevisiae YKL088W Protein required for cell viability ZYRO0E00792g similar to uniprot|P87108 Saccharomyces cerevisiae YHR005C-A MRS11 Essential protein of the mitochondrial intermembrane space forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane has homology to Mrs5p which is also involved in this process ZYRO0E00814g similar to uniprot|Q00873 Saccharomyces cerevisiae YKL087C CYT2 Cytochrome c1 heme lyase involved in maturation of cytochrome c1 which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase links heme covalently to apocytochrome c1 ZYRO0E00836g highly similar to uniprot|P08539 Saccharomyces cerevisiae YHR005C GPA1 GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response activates the pathway via Scp160p ZYRO0E00858g similar to uniprot|P36077 Saccharomyces cerevisiae YKL086W SRX1 Sulfiredoxin contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants conserved in higher eukaryotes ZYRO0E00880g highly similar to gnl|GLV|CAGL0L05236g Candida glabrata CAGL0L05236g and similar to YKL085W uniprot|P17505 Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the tricarboxylic acid (TCA) cycle ZYRO0E00902g similar to uniprot|P36078 Saccharomyces cerevisiae YKL084W HOT13 Mitochondrial intermembrane space protein first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex ZYRO0E00924g similar to uniprot|Q04749 Saccharomyces cerevisiae YMR068W AVO2 Component of a complex containing the Tor2p kinase and other proteins which may have a role in regulation of cell growth ZYRO0E00946g similar to uniprot|P54730 Saccharomyces cerevisiae YMR067C UBX4 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p ZYRO0E00968g similar to uniprot|Q04748 Saccharomyces cerevisiae YMR066W SOV1 Synthesis Of Var (putative) involved in respiration ZYRO0E00990g similar to uniprot|P36080 Saccharomyces cerevisiae YKL082C RRP14 Required for normal pre-rRNA Processing Protein required for cell viability ZYRO0E01012g similar to uniprot|P36008 Saccharomyces cerevisiae YKL081W TEF4 Translation elongation factor EF-1gamma ZYRO0E01056g highly similar to uniprot|P31412 Saccharomyces cerevisiae YKL080W VMA5 Vacuolar H ATPase subunit C of the catalytic (V1) sector ZYRO0E01078g similar to uniprot|Q759X8 Ashbya gossypii ADR145C ADR145Cp and weakly similar to YKL079W uniprot|P32364 Saccharomyces cerevisiae YKL079W SMY1 not believed to act as a kinesin colocalizes with Myo2p kinesin heavy chain homolog ZYRO0E01100g similar to uniprot|Q04746 Saccharomyces cerevisiae YMR065W KAR5 Protein required for nuclear membrane fusion during karyogamy localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen may form a complex with Jem1p and Kar2p expression of the gene is regulated by pheromone ZYRO0E01122g weakly similar to uniprot|P32493 Saccharomyces cerevisiae YMR064W AEP1 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase ZYRO0E01144g weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W ZYRO0E01166g similar to uniprot|P36009 Saccharomyces cerevisiae YKL078W DHR2 Predominantly nucleolar DEAH-box RNA helicase required for 18S rRNA synthesis ZYRO0E01188g similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane subject to glucose-induced inactivation strongly but transiently induced when cells are subjected to osmotic shock ZYRO0E01210g similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane subject to glucose-induced inactivation strongly but transiently induced when cells are subjected to osmotic shock ZYRO0E01232g highly similar to uniprot|Q04728 Saccharomyces cerevisiae YMR062C ECM40 Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine ZYRO0E01254g similar to uniprot|P25298 Saccharomyces cerevisiae YMR061W RNA14 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends bridges interaction between Rna15p and Hrp1p in the CF I complex ZYRO0E01276g similar to uniprot|P50110 Saccharomyces cerevisiae YMR060C SAM37 Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex required for the sorting of some proteins to the outer membrane after import by the TOM complex ZYRO0E01298g similar to uniprot|Q04675 Saccharomyces cerevisiae YMR059W SEN15 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p ZYRO0E01320g similar to uniprot|P36081 Saccharomyces cerevisiae YKL077W ZYRO0E01342g similar to uniprot|P36083 Saccharomyces cerevisiae YKL075C Hypothetical ORF ZYRO0E01364g similar to uniprot|P38993 Saccharomyces cerevisiae YMR058W FET3 Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity belongs to class of integral membrane multicopper oxidases ZYRO0E01386g no similarity ZYRO0E01408g similar to uniprot|P18238 Saccharomyces cerevisiae YBR085W ZYRO0E01430g highly similar to uniprot|P26448 Saccharomyces cerevisiae YMR055C BUB2 Mitotic exit network regulator forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies blocks cell cycle progression before anaphase in response to spindle and kinetochore damage ZYRO0E01452g some similarities with uniprot|P36084 Saccharomyces cerevisiae YKL074C ZYRO0E01474g similar to uniprot|P36016 Saccharomyces cerevisiae YKL073W LHS1 Molecular chaperone of the endoplasmic reticulum lumen involved in polypeptide translocation and folding member of the Hsp70 family localizes to the lumen of the ER regulated by the unfolded protein response pathway ZYRO0E01496g similar to uniprot|P37296 Saccharomyces cerevisiae YMR054W STV1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Stv1p and Vph1p) Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole ZYRO0E01518g similar to and similar to YMR053C uniprot|P46679 Saccharomyces cerevisiae YMR053C STB2 Protein that binds Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p ZYRO0E01540g similar to uniprot|P46671 Saccharomyces cerevisiae YMR052W FAR3 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far7p Far8p Far9p Far10p and Far11p ZYRO0E01584g similar to uniprot|P27697 Saccharomyces cerevisiae YGL119W ZYRO0E01606g highly similar to uniprot|P53131 Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family involved in release of the lariat-intron from the spliceosome ZYRO0E01628g similar to uniprot|P53130 Saccharomyces cerevisiae YGL121C GPG1 Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p involved in regulation of pseudohyphal growth requires Gpb1p or Gpb2p to interact with Gpa2p ZYRO0E01650g similar to uniprot|Q75E99 Ashbya gossypii AAR178C AAR178Cp and some similarites with YGL122C uniprot|P32505 Saccharomyces cerevisiae YGL122C NAB2 Nuclear polyadenylated RNA-binding protein related to human hnRNPs has a nuclear localization signal sequence that binds to Kap104p required for both poly(A) tail length control and nuclear export of mRNA ZYRO0E01672g highly similar to uniprot|P25443 Saccharomyces cerevisiae YGL123W RPS2 ZYRO0E01694g weakly similar to uniprot|P38325 Saccharomyces cerevisiae YBR230C ZYRO0E01716g similar to uniprot|P53129 Saccharomyces cerevisiae YGL124C MON1 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole associates as a complex with Ccz1p with a perivacuolar compartment potential Cdc28p substrate ZYRO0E01738g some similarities with uniprot|P40209 Saccharomyces cerevisiae YMR136W ZYRO0E01760g similar to uniprot|P38138 Saccharomyces cerevisiae YBR229C ROT2 Glucosidase II catalytic subunit required for normal cell wall synthesis mutations in rot2 suppress tor2 mutations and are synthetically lethal with rot1 mutations ZYRO0E01782g similar to uniprot|P38138 Saccharomyces cerevisiae YBR229C ROT2 Glucosidase II catalytic subunit required for normal cell wall synthesis mutations in rot2 suppress tor2 mutations and are synthetically lethal with rot1 mutations ZYRO0E01804g similar to uniprot|P38324 Saccharomyces cerevisiae YBR228W SLX1 Subunit of a complex with Slx4p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p ZYRO0E01826g similar to uniprot|P38323 Saccharomyces cerevisiae YBR227C MCX1 ZYRO0E01848g similar to uniprot|P38321 Saccharomyces cerevisiae YBR225W Hypothetical ORF ZYRO0E01870g highly similar to uniprot|P53128 Saccharomyces cerevisiae YGL125W MET13 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway ZYRO0E01892g no similarity ZYRO0E01914g similar to uniprot|P38319 Saccharomyces cerevisiae YBR223C TDP1 Tyrosine-DNA Phosphodiesterase ZYRO0E01936g highly similar to uniprot|P38137 Saccharomyces cerevisiae YBR222C PCS60 ZYRO0E01958g similar to uniprot|Q12289 Saccharomyces cerevisiae YOR100C CRC1 Mitochondrial inner membrane carnitine transporter required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation ZYRO0E01980g similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1 2-mannosyltransferase involved in O-and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family ZYRO0E02002g some similarities with uniprot|P14907 Saccharomyces cerevisiae YJL041W NSP1 Essential component of the nuclear pore complex which mediates nuclear import and export ZYRO0E02024g some similarities with uniprot|Q12274 Saccharomyces cerevisiae YOR097C ZYRO0E02046g highly similar to uniprot|P26786 Saccharomyces cerevisiae YOR096W ZYRO0E02068g highly similar to gnl|GLV|CAGL0L03740g Candida glabrata CAGL0L03740g and similar to YOR095C uniprot|Q12189 Saccharomyces cerevisiae YOR095C RKI1 Ribose-5-phosphate ketol-isomerase ZYRO0E02090g highly similar to uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP-ribosylation factor GTPase of the Ras superfamily involved in development of polarity ZYRO0E02134g similar to uniprot|Q12275 Saccharomyces cerevisiae YOR093C Hypothetical ORF ZYRO0E02156g similar to uniprot|Q99252 Saccharomyces cerevisiae YOR092W ECM3 Non-essential protein of unknown function ZYRO0E02200g conserved hypothetical protein ZYRO0E02222g similar to uniprot|P38172 Saccharomyces cerevisiae YBL095W Hypothetical ORF ZYRO0E02266g weakly similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. ZYRO0E02288g similar to gnl|GLV|KLLA0D12606g Kluyveromyces lactis KLLA0D12606g and some similarities with YNR055C uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake ZYRO0E02310g similar to uniprot|P38682 Saccharomyces cerevisiae YER122C ZYRO0E02332g similar to uniprot|P25046 Saccharomyces cerevisiae YBL093C ROX3 RNA polymerase II holoenzyme component ZYRO0E02354g similar to uniprot|P40077 Saccharomyces cerevisiae YER124C DSE1 Daughter cell-specific protein may participate in pathways regulating cell wall metabolism deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall ZYRO0E02376g some similarities with uniprot|P39962 Saccharomyces cerevisiae YER123W YCK3 plasma membrane-bound casein kinase I homolog ZYRO0E02398g similar to gnl|GLV|KLLA0E13541g Kluyveromyces lactis KLLA0E13541g and some similarites with YPR023C uniprot|Q12432 Saccharomyces cerevisiae YPR023C EAF3 Esa1p-associated factor nonessential component of the NuA4 acetyltransferase complex homologous to Drosophila dosage compensation protein MSL3 ZYRO0E02420g similar to uniprot|Q12482 Saccharomyces cerevisiae YPR021C AGC1 Mitochondrial transporter acts both as a glutamate uniporter and as an aspartate-glutamate exchanger involved in nitrogen metabolism ornithine synthesis and the malate-aspartate NADH shuttle ZYRO0E02442g similar to uniprot|P46946 Saccharomyces cerevisiae YGL175C SAE2 Protein with a role in accurate meiotic and mitotic double-strand break repair phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents ZYRO0E02464g weakly similar to uniprot|P46947 Saccharomyces cerevisiae YGL174W BUD13 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern ZYRO0E02486g similar to uniprot|P22147 Saccharomyces cerevisiae YGL173C KEM1 5'-3' exonuclease involved in mRNA decay evolutionarily conserved component of cytoplasmic processing (P) bodies plays a role in microtubule-mediated processes filamentous growth and ribosomal RNA maturation ZYRO0E02508g some similarities with uniprot|Q02199 Saccharomyces cerevisiae YGL172W NUP49 Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC) required for nuclear export of ribosomes ZYRO0E02530g highly similar to uniprot|P45818 Saccharomyces cerevisiae YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family required for 18S rRNA synthesis ZYRO0E02552g similar to uniprot|Q12233 Saccharomyces cerevisiae YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase which is a large enzyme complex required for ATP synthesis associated only with the dimeric form of ATP synthase ZYRO0E02574g highly similar to uniprot|P30665 Saccharomyces cerevisiae YPR019W CDC54 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication accumulates in the nucleus in G1 homolog of S. pombe Cdc21p ZYRO0E02596g some similarities with uniprot|Q12495 Saccharomyces cerevisiae YPR018W RLF2 Chromatin Assembly Complex subunit 1: largest (p90) subunit of three-subunit protein complex (yeast CAF-I) involved in DNA-replication-linked nucleosome assembly. Homol. to p150 subunit human Chromatin Assembly Factor-I (CAF-I) p90 subunit of yeast Chromatin Assembly Factor-I (CAF-I) ZYRO0E02618g conserved hypothetical protein ZYRO0E02662g highly similar to uniprot|Q12522 Saccharomyces cerevisiae YPR016c TIF6 translation initiation factor 6 (eIF6) singleton ZYRO0E02684g weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF ZYRO0E02728g similar to uniprot|Q12251 Saccharomyces cerevisiae YPR011C Hypothetical ORF ZYRO0E02750g conserved hypothetical protein ZYRO0E02772g conserved hypothetical protein ZYRO0E02838g highly similar to uniprot|P22138 Saccharomyces cerevisiae YPR010C RPA135 RNA polymerase I subunit A135 ZYRO0E02860g highly similar to uniprot|P13586 Saccharomyces cerevisiae YGL167C PMR1 High affinity Ca2 /Mn2 P-type ATPase required for Ca2 and Mn2 transport into Golgi involved in Ca2 dependent protein sorting and processing mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease ZYRO0E02882g similar to uniprot|P32579 Saccharomyces cerevisiae YGL169W SUA5 Protein required for respiratory growth null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start ZYRO0E02926g no similarity ZYRO0E02948g similar to uniprot|P47110 Saccharomyces cerevisiae YJR043C POL32 Third subunit of DNA polymerase delta involved in chromosomal DNA replication required for error-prone DNA synthesis in the presence of DNA damage and processivity interacts with Pol31p PCNA (Pol30p) and Pol1p ZYRO0E02970g similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H()-ATPase V0 sector required for vacuolar acidification and important for copper and iron metal ion homeostasis ZYRO0E02992g similar to uniprot|P46673 Saccharomyces cerevisiae YJR042W NUP85 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking ZYRO0E03014g similar to uniprot|P47108 Saccharomyces cerevisiae YJR041C URB2 Nucleolar protein required for normal metabolism of the rRNA primary transcript proposed to be involved in ribosome biogenesis ZYRO0E03036g similar to uniprot|P37020 Saccharomyces cerevisiae YJR040W GEF1 Chloride channel localized to late- or post-Golgi vesicles involved in iron metabolism highly homologous to voltage-gated chloride channels in vertebrates ZYRO0E03058g highly similar to uniprot|P39990 Saccharomyces cerevisiae YEL026W SNU13 RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein ZYRO0E03080g weakly similar to uniprot|P39991 Saccharomyces cerevisiae YEL025C ZYRO0E03102g weakly similar to uniprot|P47107 Saccharomyces cerevisiae YJR039W Hypothetical ORF ZYRO0E03124g similar to uniprot|P40985 Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability ZYRO0E03146g highly similar to gnl|GLV|DEHA0F12771g Debaryomyces hansenii DEHA0F12771g and similar to YEL024W uniprot|P08067 Saccharomyces cerevisiae YEL024W RIP1 oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex ZYRO0E03168g similar to uniprot|P39992 Saccharomyces cerevisiae YEL023C Hypothetical ORF ZYRO0E03190g similar to uniprot|P40352 Saccharomyces cerevisiae YJR035W RAD26 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSB protein ZYRO0E03256g similar to uniprot|Q02772 Saccharomyces cerevisiae YJR034W PET191 Protein required for assembly of cytochrome c oxidase ZYRO0E03278g similar to uniprot|P47104 Saccharomyces cerevisiae YJR033C RAV1 Subunit of the RAVE complex (Rav1p Rav2p Skp1p) which promotes assembly of the V-ATPase holoenzyme required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins potential Cdc28p substrate ZYRO0E03300g similar to uniprot|P47103 Saccharomyces cerevisiae YJR032W CPR7 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity ZYRO0E03322g similar to uniprot|P39993 Saccharomyces cerevisiae YEL022W ZYRO0E03344g conserved hypothetical protein ZYRO0E03366g highly similar to uniprot|P03962 Saccharomyces cerevisiae YEL021W URA3 orotidine-5'-phosphate decarboxylase ZYRO0E03388g highly similar to uniprot|O74700 Saccharomyces cerevisiae YEL020W-A TIM9 Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins ZYRO0E03410g similar to uniprot|P25351 Saccharomyces cerevisiae YCR023C Hypothetical ORF ZYRO0E03454g similar to uniprot|P39994 Saccharomyces cerevisiae YEL020C Hypothetical ORF ZYRO0E03476g similar to uniprot|P25345 Saccharomyces cerevisiae YCR024C SLM5 Mitochondrial asparaginyl-tRNA synthetase ZYRO0E03498g similar to uniprot|P38632 Saccharomyces cerevisiae YEL019C MMS21 Protein involved in DNA repair mutants are sensitive to the alkylating agent methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination ZYRO0E03520g similar to uniprot|P39995 Saccharomyces cerevisiae YEL018W ZYRO0E03542g no similarity ZYRO0E03564g some similarities with uniprot|P25353 Saccharomyces cerevisiae YCR026C NPP1 Hypothetical ORF and to YEL016C uniprot|P39997 Saccharomyces cerevisiae YEL016C NPP2 Hypothetical ORF ZYRO0E03586g conserved hypothetical protein ZYRO0E03608g similar to uniprot|P25378 Saccharomyces cerevisiae YCR027C RHB1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake member of the Ras superfamily of G-proteins ZYRO0E03630g similar to uniprot|P39998 Saccharomyces cerevisiae YEL015W EDC3 Non-essential conserved protein of unknown function plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p localizes to cytoplasmic mRNA processing bodies ZYRO0E03652g highly similar to uniprot|P39968 Saccharomyces cerevisiae YEL013W VAC8 Phosphorylated vacuolar membrane protein that interacts with Atg13p required for the cytoplasm-to-vacuole targeting (Cvt) pathway interacts with Nvj1p to form nucleus-vacuole junctions ZYRO0E03718g similar to uniprot|P23060 Saccharomyces cerevisiae YCR019W MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles ZYRO0E03740g similar to uniprot|P25362 Saccharomyces cerevisiae YCR020C PET18 Protein required for respiratory growth and stability of the mitochondrial genome ZYRO0E03762g similar to uniprot|P23059 Saccharomyces cerevisiae YCR020C-A MAK31 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus member of the Sm protein family ZYRO0E03784g similar to uniprot|Q9URQ5 Saccharomyces cerevisiae YCR020W-B ZYRO0E03806g highly similar to uniprot|P28263 Saccharomyces cerevisiae YEL012W UBC8 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1 6-bisphosphatase (FBPase) cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro ZYRO0E03828g highly similar to uniprot|P32775 Saccharomyces cerevisiae YEL011W GLC3 Glycogen branching enzyme involved in glycogen accumulation green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0E03872g similar to uniprot|P25618 Saccharomyces cerevisiae YCR017C CWH43 Putative sensor/transporter protein involved in cell wall biogenesis contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites null mutation is synthetically lethal with pkc1 deletion ZYRO0E03894g similar to uniprot|P40342 Saccharomyces cerevisiae YNR004W Hypothetical ORF ZYRO0E03916g weakly similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W ZYRO0E03938g similar to uniprot|P25617 Saccharomyces cerevisiae YCR016W Hypothetical ORF ZYRO0E04004g similar to uniprot|P25616 Saccharomyces cerevisiae YCR015C Hypothetical ORF ZYRO0E04026g no similarity ZYRO0E04048g similar to uniprot|P25615 Saccharomyces cerevisiae YCR014C POL4 Probable homolog of mammalian DNA polymerase beta may function in double-stranded DNA break repair DNA polymerase IV ZYRO0E04070g highly similar to uniprot|P00560 Saccharomyces cerevisiae YCR012W PGK1 3-phosphoglycerate kinase catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1 3-bisphosphoglycerate to ADP to produce ATP key enzyme in glycolysis and gluconeogenesis ZYRO0E04092g similar to uniprot|P25371 Saccharomyces cerevisiae YCR011C ADP1 Shows homology to ATP-dependent permeases Active transport ATPase ZYRO0E04114g highly similar to uniprot|P32910 Saccharomyces cerevisiae YNR003C RPC34 RNA polymerase III subunit C34 interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex ZYRO0E04136g no similarity ZYRO0E04158g similar to uniprot|P25613 Saccharomyces cerevisiae YCR010C ADY2 Accumulation of DYads member of the TC 9.B.33 YaaH family of putative transporters Protein involved in Accumulation of DYads ZYRO0E04180g similar to uniprot|P32907 Saccharomyces cerevisiae YNR002C FUN34 Putative transmembrane protein involved in ammonia production member of the TC 9.B.33 YaaH family homolog of Ady2p and Y. lipolytica Gpr1p ZYRO0E04202g highly similar to uniprot|P25343 Saccharomyces cerevisiae YCR009C RVS161 BAR adaptor protein subunit of a complex (Rvs161p Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress ZYRO0E04224g conserved hypothetical protein ZYRO0E04246g similar to uniprot|P25333 Saccharomyces cerevisiae YCR008W ZYRO0E04290g highly similar to uniprot|P00890 Saccharomyces cerevisiae YNR001C CIT1 Citrate synthase catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate the rate-limiting enzyme of the TCA cycle nuclear encoded mitochondrial protein ZYRO0E04312g highly similar to gnl|GLV|DEHA0F18447g Debaryomyces hansenii DEHA0F18447g and similar to YCR004C uniprot|P25349 Saccharomyces cerevisiae YCR004C YCP4 Protein of unknown function, has sequence and structural similarity to flavodoxins; green fluorescent protein (GFP)- fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0E04334g no similarity ZYRO0E04356g similar to uniprot|P25348 Saccharomyces cerevisiae YCR003W MRPL32 Mitochondrial ribosomal protein of the large subunit ZYRO0E04378g highly similar to uniprot|P25342 Saccharomyces cerevisiae YCR002C CDC10 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM ZYRO0E04422g uniprot|Q96WU4 Zygosaccharomyces rouxii el001w Hypothetical protein el001w similar to YNL001W uniprot|P33309 Saccharomyces cerevisiae YNL001W DOM34 Probable RNA- binding protein functions in protein translation to promote G1 progression and differentiation required for meiotic cell division ZYRO0E04444g similar to uniprot|P25560 Saccharomyces cerevisiae YCL001W RER1 Protein involved in retention of membrane proteins including Sec12p in the ER localized to Golgi functions as a retrieval receptor in returning membrane proteins to the ER ZYRO0E04466g similar to uniprot|P25565 Saccharomyces cerevisiae YCL002C Hypothetical ORF ZYRO0E04488g similar to uniprot|P25578 Saccharomyces cerevisiae YCL004W PGS1 Phosphatidylglycerolphosphate synthase catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis ZYRO0E04532g some similarities with uniprot|P25587 Saccharomyces cerevisiae YCL005W ZYRO0E04554g similar to uniprot|P25604 Saccharomyces cerevisiae YCL008C STP22 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome homologous to the mouse and human Tsg101 tumor susceptibility gene mutants exhibit a Class E Vps phenotype ZYRO0E04576g similar to uniprot|P33322 Saccharomyces cerevisiae YLR175W CBF5 Component of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs) probable rRNA pseudouridine synthase binds to snoRNP Nop10p and also interacts with ribosomal biogenesis protein Nop53p ZYRO0E04598g some similarities with uniprot|P25294 Saccharomyces cerevisiae YNL007C SIS1 HSP40 family chaperone sit4 suppressor dnaJ homolog ZYRO0E04620g highly similar to uniprot|P41318 Saccharomyces cerevisiae YNL006W LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface component of the TOR signaling pathway associates with both Tor1p and Tor2p contains a WD-repeat ZYRO0E04642g some similarities with uniprot|P48743 Saccharomyces cerevisiae YLR176C ZYRO0E04686g similar to uniprot|P40693 Saccharomyces cerevisiae YNL002C ZYRO0E04708g conserved hypothetical protein ZYRO0E04752g no similarity ZYRO0E04774g no similarity ZYRO0E04796g uniprot|Q96WI0 Zygosaccharomyces rouxii LEU2 3-isopropylmalate dehydrogenase ZYRO0E04818g highly similar to uniprot|P25374 Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S)biogenesis required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs essential protein located predominantly in mitochondria ZYRO0E04840g similar to uniprot|P38921 Saccharomyces cerevisiae YNL003C PET8 S-adenosylmethionine transporter of the mitochondrial inner membrane member of the mitochondrial carrier family required for biotin biosynthesis and respiratory growth ZYRO0E04862g similar to uniprot|P25559 Saccharomyces cerevisiae YCL016C DCC1 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C required for sister chromatid cohesion ZYRO0E04884g weakly similar to uniprot|P25558 Saccharomyces cerevisiae YCL014W BUD3 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding ZYRO0E04906g similar to uniprot|Q8J0M4 Saccharomyces cerevisiae YCL012C ZYRO0E04928g similar to uniprot|P38922 Saccharomyces cerevisiae YNL004W ZYRO0E04950g similar to uniprot|P25554 Saccharomyces cerevisiae YCL010C SGF29 SaGa associated Factor 29kDa Probable 29kKDa Subunit of SAGA histone acetyltransferase complex ZYRO0E04972g similar to uniprot|P12687 Saccharomyces cerevisiae YNL005C MRP7 Mitochondrial ribosomal protein of the large subunit ZYRO0E04994g highly similar to uniprot|P25605 Saccharomyces cerevisiae YCL009C ILV6 Regulatory subunit of acetolactate synthase which catalyzes the first step of branched-chain amino acid biosynthesis enhances activity of the Ilv2p catalytic subunit localizes to mitochondria ZYRO0E05016g highly similar to uniprot|P41939 Saccharomyces cerevisiae YLR174W IDP2 Cytosolic NADP-specific isocitrate dehydrogenase catalyzes oxidation of isocitrate to alpha-ketoglutarate levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose ZYRO0E05060g highly similar to uniprot|P53981 Saccharomyces cerevisiae YNL010W Hypothetical ORF ZYRO0E05082g similar to uniprot|P53980 Saccharomyces cerevisiae YNL011C Hypothetical ORF ZYRO0E05104g similar to uniprot|P39931 Saccharomyces cerevisiae YLR250W SSP120 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0E05126g similar to uniprot|P53541 Saccharomyces cerevisiae YNL012W ZYRO0E05148g highly similar to uniprot|P16521 Saccharomyces cerevisiae YLR249W YEF3 stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex contains two ABC cassettes and binds and hydrolyses ATP EF-3 (translational elongation factor 3) ZYRO0E05170g some similarities with uniprot|P38623 Saccharomyces cerevisiae YLR248W RCK2 Protein kinase involved in the response to oxidative stress identified as suppressor of S. pombe cell cycle checkpoint mutations ZYRO0E05192g similar to uniprot|Q06554 Saccharomyces cerevisiae YLR247C Hypothetical ORF ZYRO0E05214g similar to gnl|GLV|KLLA0F22792g Kluyveromyces lactis KLLA0F22792g and some similarites with YMR252C uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF ZYRO0E05236g highly similar to uniprot|P35181 Saccharomyces cerevisiae YLR170C APS1 Small subunit of the clathrin-associated adaptor complex AP-1 which is involved in protein sorting at the trans-Golgi network homolog of the sigma subunit of the mammalian clathrin AP-1 complex ZYRO0E05258g highly similar to uniprot|P32469 Saccharomyces cerevisiae YLR172C DPH5 Methyltransferase required for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) not essential for viability GFP-Dph5p fusion protein localizes to the cytoplasm ZYRO0E05280g similar to gnl|GLV|KLLA0F22858g Kluyveromyces lactis KLLA0F22858g and weakly similar to YLR173W uniprot|Q06247 Saccharomyces cerevisiae YLR173W Hypothetical ORF ZYRO0E05302g conserved hypothetical protein ZYRO0E05346g similar to uniprot|Q06567 Saccharomyces cerevisiae YLR253W Hypothetical ORF ZYRO0E05368g similar to uniprot|Q06568 Saccharomyces cerevisiae YLR254C NDL1 homolog of nuclear distribution factor NudE NUDEL ZYRO0E05390g similar to uniprot|P53110 Saccharomyces cerevisiae YGL159W Hypothetical ORF ZYRO0E05412g similar to uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1 ZYRO0E05434g weakly similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 ZYRO0E05456g similar to uniprot|P53109 Saccharomyces cerevisiae YGL160W Hypothetical ORF ZYRO0E05500g weakly similar to uniprot|Q06146 Saccharomyces cerevisiae YLR257W Hypothetical ORF ZYRO0E05522g weakly similar to uniprot|P43597 Saccharomyces cerevisiae YFR016C Hypothetical ORF ZYRO0E05544g conserved hypothetical protein ZYRO0E05566g highly similar to uniprot|P23337 Saccharomyces cerevisiae or YLR258W uniprot|P27472 Saccharomyces cerevisiae ZYRO0E05588g similar to uniprot|P22517 Saccharomyces cerevisiae YOL016C CMK2 Calmodulin-dependent protein kinase and to YFR014C uniprot|P27466 Saccharomyces cerevisiae YFR014C CMK1 Calmodulin-dependent protein kinase ZYRO0E05610g similar to uniprot|P43596 Saccharomyces cerevisiae YFR013W IOC3 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome has homology to Esc8p which is involved in silencing ZYRO0E05632g similar to uniprot|P36096 Saccharomyces cerevisiae YKL034W TUL1 Transmembrane Ubiquitin Ligase ZYRO0E05654g highly similar to uniprot|P32861 Saccharomyces cerevisiae YKL035W UGP1 UDP-glucose pyrophosphorylase or UTP-glucose-1-phosphate uridylyltransferase EC:2.7.7.9 ZYRO0E05676g some similarities with uniprot|P32862 Saccharomyces cerevisiae YKL038W RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose binds to promoters and acts both as a transcriptional activator and repressor ZYRO0E05698g similar to uniprot|P38747 Saccharomyces cerevisiae YHL013C Hypothetical ORF ZYRO0E05720g highly similar to uniprot|P38746 Saccharomyces cerevisiae YHL014C YLF2 Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1 ZYRO0E05764g highly similar to uniprot|P38701 Saccharomyces cerevisiae YHL015W RPS20 ZYRO0E05786g conserved hypothetical protein ZYRO0E05808g similar to uniprot|P32857 Saccharomyces cerevisiae YKL039W PTM1 Putative membrane protein ZYRO0E05830g similar to uniprot|P32860 Saccharomyces cerevisiae YKL040C ZYRO0E05852g similar to uniprot|P38744 Saccharomyces cerevisiae YHL018W Hypothetical ORF ZYRO0E05874g similar to uniprot|P38700 Saccharomyces cerevisiae YHL019C APM2 homologous to the medium chain of mammalian clathrin-associated protein complex Similar to clathrin coat proteins ZYRO0E05896g conserved hypothetical protein ZYRO0E05918g weakly similar to uniprot|P21957 Saccharomyces cerevisiae YHL020C OPI1 Transcriptional regulator of a variety of genes phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes ZYRO0E05940g highly similar to uniprot|P36095 Saccharomyces cerevisiae YKL041W VPS24 involved in secretion ZYRO0E05984g similar to uniprot|Q03690 Saccharomyces cerevisiae YMR012W ZYRO0E06006g similar to uniprot|P20048 Saccharomyces cerevisiae YMR013C SEC59 Membrane protein that catalyzes the CTP-mediated phosphorylation of dolichol the terminal step in dolichyl monophosphate (Dol-P) biosynthesis required for viability normal rates of lipid intermediate synthesis and protein N-glycosylation ZYRO0E06182g weakly similar to uniprot|Q04347 Saccharomyces cerevisiae YMR014W BUD22 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ZYRO0E06204g highly similar to uniprot|P54781 Saccharomyces cerevisiae YMR015C ERG5 C-22 sterol desaturase a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis may be a target of azole antifungal drugs ZYRO0E06226g similar to uniprot|Q75DH2 Ashbya gossypii ABR054C ABR054Cp and weakly similar to YKL042W uniprot|P36094 Saccharomyces cerevisiae YKL042W SPC42 Central plaque component of spindle pole body (SPB) involved in SPB duplication may facilitate attachment of the SPB to the nuclear membrane ZYRO0E06248g some similarities with uniprot|P53438 Saccharomyces cerevisiae YMR016C SOK2 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase displays homologies to several transcription factors ZYRO0E06270g weakly similar to uniprot|P50104 Saccharomyces cerevisiae YMR019W STB4 Protein that binds Sin3p in a two-hybrid assay ZYRO0E06292g highly similar to uniprot|P20457 Saccharomyces cerevisiae YKL045W PRI2 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair ZYRO0E06314g similar to uniprot|P50264 Saccharomyces cerevisiae YMR020W FMS1 Polyamine oxidase converts spermine to spermidine which is required for the essential hypusination modification of translation factor eIF-5A also involved in pantothenic acid biosynthesis ZYRO0E06336g similar to uniprot|P35192 Saccharomyces cerevisiae YMR021C MAC1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport ZYRO0E06358g highly similar to uniprot|Q02159 Saccharomyces cerevisiae YMR022W QRI8 Ubiquitin conjugating enzyme involved in the ER-associated protein degradation pathway requires Cue1p for recruitment to the ER membrane proposed to be involved in chromatin assembly ZYRO0E06380g similar to uniprot|P36091 Saccharomyces cerevisiae YKL046C DCW1 Mannosidase GPI-anchored membrane protein required for cell wall biosynthesis homologous to Dfg5p ZYRO0E06402g similar to uniprot|P36090 Saccharomyces cerevisiae YKL047W Hypothetical ORF ZYRO0E06424g similar to uniprot|P35727 Saccharomyces cerevisiae YKL061W Hypothetical ORF ZYRO0E06446g similar to uniprot|P32559 Saccharomyces cerevisiae YMR023C ZYRO0E06490g highly similar to uniprot|P36516 Saccharomyces cerevisiae YMR024W MRPL3 Mitochondrial ribosomal protein of the large subunit ZYRO0E06512g weakly similar to uniprot|Q04368 Saccharomyces cerevisiae YMR025W CSI1 Subunit of the Cop9 signalosome which is required for deneddylation or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin) involved in adaptation to pheromone signaling ZYRO0E06534g similar to uniprot|Q04370 Saccharomyces cerevisiae YMR026C PEX12 RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import forms translocation subcomplex with Pex2p and Pex10p ZYRO0E06556g highly similar to uniprot|P14540 Saccharomyces cerevisiae YKL060C FBA1 Fructose 1 6-bisphosphate aldolase required for glycolysis and gluconeogenesis ZYRO0E06578g similar to uniprot|Q04371 Saccharomyces cerevisiae YMR027W High level expression reduced Ty3 Transposition ZYRO0E06600g similar to uniprot|P35728 Saccharomyces cerevisiae YKL059C MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor) plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA contains a putative RNA-binding zinc knuckle motif ZYRO0E06622g highly similar to uniprot|P32774 Saccharomyces cerevisiae YKL058W TOA2 Transcription factor IIA small chain ZYRO0E06644g similar to uniprot|Q04372 Saccharomyces cerevisiae YMR028W TAP42 Protein that physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits ZYRO0E06666g similar to uniprot|P35729 Saccharomyces cerevisiae YKL057C NUP120 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for even distribution of NPCs around the nuclear envelope involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p ZYRO0E06688g similar to uniprot|Q05040 Saccharomyces cerevisiae YMR029C FAR8 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far9p Far10p and Far11p ZYRO0E06710g highly similar to uniprot|P35691 Saccharomyces cerevisiae YKL056C RBF18 Hypothetical ORF ZYRO0E06732g similar to uniprot|P35731 Saccharomyces cerevisiae YKL055C OAR1 Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase may comprise a type II mitochondrial fatty acid synthase along with Mct1p ZYRO0E06754g some similarities with uniprot|P35732 Saccharomyces cerevisiae YKL054C DEF1 RNAPII degradation factor forms a complex with Rad26p in chromatin enables ubiquitination and proteolysis of RNAPII ZYRO0E06776g highly similar to uniprot|O60200 Saccharomyces cerevisiae YKL053C-A MDM35 Mitochondrial Distribution and Morphology Similar to human sequence predicted by GENSCAN ZYRO0E06798g conserved hypothetical protein ZYRO0E06820g similar to uniprot|Q3E790 Saccharomyces cerevisiae YBR058C-A TSC3 Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p Lcb2p) several-fold involved in sphingolipid biosynthesis ZYRO0E06842g similar to uniprot|Q3E790 Saccharomyces cerevisiae YBR058C-A TSC3 ZYRO0E06864g some similarities with uniprot|P38080 Saccharomyces cerevisiae YBR059C AKL1 Serine-threonine protein kinase member (with Ark1p and Prk1p) of the Ark kinase family ZYRO0E06886g similar to uniprot|P32833 YBR060C Saccharomyces cerevisiae ORC2 Subunit of the origin recognition complex ZYRO0E06908g highly similar to uniprot|P15180 Saccharomyces cerevisiae YDR037W KRS1 Lysyl-tRNA synthetase also identified as a negative regulator of general control of amino acid biosynthesis ZYRO0E06930g uniprot|P78981 Zygosaccharomyces rouxii Z Na - ATPase ZYRO0E06952g highly similar to uniprot|P38238 Saccharomyces cerevisiae YBR061C TRM7 2'-O-ribose methyltransferase methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop ZYRO0E06974g highly similar to uniprot|Q03201 Saccharomyces cerevisiae YDR041W RSM10 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins ZYRO0E06996g similar to uniprot|P38239 Saccharomyces cerevisiae YBR062C Hypothetical ORF ZYRO0E07018g similar to uniprot|P38991 Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase involved in regulating kinetochore-microtubule attachments associates with Sli5p which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle potential Cdc28p substrate ZYRO0E07040g similar to uniprot|P53166 Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial RNA helicase plays an essential role in mitochondrial function ZYRO0E07062g similar to uniprot|P38688 Saccharomyces cerevisiae YPL210C SRP72 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane ZYRO0E07084g highly similar to uniprot|Q08962 Saccharomyces cerevisiae YPL211W NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis ZYRO0E07106g similar to uniprot|Q12211 Saccharomyces cerevisiae YPL212C PUS1 Involved in tRNA biogenesis; intranuclear protein which exhibits a nucleotide-specific intron-dependent tRNA pseudouridine synthase activity ZYRO0E07128g similar to uniprot|Q01163 Saccharomyces cerevisiae YGL129C RSM23 Mitochondrial ribosomal protein of the small subunit ZYRO0E07150g highly similar to uniprot|Q01159 Saccharomyces cerevisiae YGL130W CEG1 mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit ZYRO0E07172g similar to uniprot|P53127 Saccharomyces cerevisiae YGL131C SNT2 22% sequence identity with S. pombe Snt2 ZYRO0E07194g similar to uniprot|Q08963 Saccharomyces cerevisiae YPL213W LEA1 Component of U2 snRNP disruption causes reduced U2 snRNP levels physically interacts with Msl1p putative homolog of human U2A' snRNP protein ZYRO0E07216g similar to uniprot|P41835 Saccharomyces cerevisiae YPL214C THI6 bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities ZYRO0E07238g similar to uniprot|P21560 Saccharomyces cerevisiae YPL215W CBP3 protein required for assembly of ubiquinol cytochrome-c reductase complex ZYRO0E07260g similar to uniprot|P53125 Saccharomyces cerevisiae YGL133W ITC1 Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex required for repression of a-specific genes repression of early meiotic genes during mitotic growth and repression of INO1 ZYRO0E07282g similar to uniprot|Q08965 Saccharomyces cerevisiae YPL217C BMS1 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p ZYRO0E07304g highly similar to uniprot|P20606 Saccharomyces cerevisiae YPL218W SAR1 GTPase GTP-binding protein of the ARF family component of COPII coat of vesicles required for transport vesicle formation during ER to Golgi protein transport ZYRO0E07326g weakly similar to uniprot|P53124 Saccharomyces cerevisiae YGL134W PCL10 Pho85p cyclin recruits activates and targets Pho85p cyclin-dependent protein kinase to its substrate ZYRO0E07348g highly similar to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1A and highly similar to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1B N-terminally acetylated protein component of the large (60S) ribosomal subunit ZYRO0E07370g similar to uniprot|P53123 Saccharomyces cerevisiae YGL136C MRM2 Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ ZYRO0E07392g highly similar to uniprot|P41811 Saccharomyces cerevisiae YGL137W SEC27 Involved in beta'-subunit of yeast coatomer ZYRO0E07414g weakly similar to uniprot|P53122 Saccharomyces cerevisiae YGL138C Hypothetical ORF ZYRO0E07436g similar to uniprot|Q08967 Saccharomyces cerevisiae YPL221W BOP1 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation ZYRO0E07458g weakly similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria ZYRO0E07480g similar to uniprot|Q08968 Saccharomyces cerevisiae YPL222W FMP40 The authentic non-tagged protein was localized to the mitochondria ZYRO0E07502g some similarities with uniprot|Q03213 Saccharomyces cerevisiae YMR172W ZYRO0E07524g weakly similar to uniprot|P18899 Saccharomyces cerevisiae YMR173W DDR48 DNA damage-responsive protein expression is increased in response to heat-shock stress or treatments that produce DNA lesions ZYRO0E07546g weakly similar to uniprot|Q03214 Saccharomyces cerevisiae YMR176W ECM5 Non-essential protein of unknown function contains ATP/GTP-binding site motif A null mutant exhibits cellular volume up to four times greater than wild-type also large drooping buds with elongated necks ZYRO0E07568g similar to uniprot|Q03218 Saccharomyces cerevisiae YMR177W MMT1 Putative metal transporter involved in mitochondrial iron accumulation closely related to Mmt2p ZYRO0E07590g highly similar to uniprot|Q08971 Saccharomyces cerevisiae YPL225W Hypothetical ORF ZYRO0E07612g highly similar to uniprot|Q03219 Saccharomyces cerevisiae YMR178W Hypothetical ORF ZYRO0E07634g highly similar to uniprot|Q7LHP2 Saccharomyces cerevisiae YPL226W NEW1 This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion termed [NU] ZYRO0E07656g similar to uniprot|P35209 Saccharomyces cerevisiae YMR179W SPT21 Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2 but not required at the other histone loci functionally related to Spt10p ZYRO0E07678g similar to uniprot|P40350 Saccharomyces cerevisiae YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase involved in asparagine-linked glycosylation in the endoplasmic reticulum ZYRO0E07700g highly similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate-terminated RNA mRNA capping enzyme beta subunit RNA 5'-triphosphatase ZYRO0E07722g some similarities with uniprot|Q99395 Saccharomyces cerevisiae YPL229W Hypothetical ORF ZYRO0E07744g similar to uniprot|P15992 Saccharomyces cerevisiae YBR072W HSP26 Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer induced by heat upon entry into stationary phase and during sporulation ZYRO0E07766g highly similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains beta-ketoacyl reductase and beta-ketoacyl synthase activities ZYRO0E07788g similar to uniprot|P32867 Saccharomyces cerevisiae YPL232W SSO1 encode syntaxin homolog act in late stages of secretion post-Golgi t-SNARE ZYRO0E07810g similar to uniprot|Q6B152 Saccharomyces cerevisiae YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules required for accurate chromosome segregation ZYRO0E07832g similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c' ZYRO0E07854g highly similar to uniprot|Q12464 Saccharomyces cerevisiae YPL235W RVB2 RUVB-like protein TIP49b Homologue ZYRO0E07876g similar to uniprot|Q7LGU7 Saccharomyces cerevisiae YPL236C Hypothetical ORF ZYRO0E07898g similar to gnl|GLV|KLLA0D08954g Kluyveromyces lactis KLLA0D08954g and weakly similar to YMR184W uniprot|Q03233 Saccharomyces cerevisiae YMR184W Hypothetical ORF ZYRO0E07920g similar to uniprot|P09064 Saccharomyces cerevisiae YPL237W SUI3 Beta subunit of the translation initiation factor eIF2 involved in the identification of the start codon ZYRO0E07942g similar to uniprot|P46683 Saccharomyces cerevisiae YPL239W YAR1 ZYRO0E07964g similar to uniprot|Q12751 Saccharomyces cerevisiae YMR185W Protein required for cell viability ZYRO0E07986g highly similar to uniprot|P15108 Saccharomyces cerevisiae YMR186W HSC82 Cytoplasmic chaperone of the Hsp90 family ZYRO0E08008g weakly similar to uniprot|P46670 Saccharomyces cerevisiae YPL241C CIN2 Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl ZYRO0E08030g similar to uniprot|Q12280 Saccharomyces cerevisiae YPL242C IQG1 Essential protein required for determination of budding pattern promotes localization of axial markers Bud4p and Cdc12p ZYRO0E08052g similar to uniprot|Q03236 Saccharomyces cerevisiae YMR187C Hypothetical ORF ZYRO0E08074g similar to uniprot|P38687 Saccharomyces cerevisiae YPL243W SRP68 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane ZYRO0E08096g similar to uniprot|Q12520 Saccharomyces cerevisiae YPL244C HUT1 Protein with a role in UDP-galactose transport to the Golgi lumen ZYRO0E08118g similar to uniprot|Q12179 Saccharomyces cerevisiae YPL245W Hypothetical ORF ZYRO0E08140g similar to uniprot|Q12270 Saccharomyces cerevisiae YPL246C RBD2 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p ZYRO0E08162g highly similar to uniprot|Q03246 Saccharomyces cerevisiae YMR188C MRPS17 Mitochondrial ribosomal protein of the small subunit ZYRO0E08184g similar to uniprot|Q12523 Saccharomyces cerevisiae YPL247C Hypothetical ORF ZYRO0E08206g highly similar to uniprot|P49095 Saccharomyces cerevisiae YMR189W GCV2 P subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm ZYRO0E08228g similar to uniprot|P39709 Saccharomyces cerevisiae YAL067C SEO1 Putative permease member of the allantoate transporter subfamily of the major facilitator superfamily mutation confers resistance to ethionine sulfoxide ZYRO0E08250g similar to uniprot|P35187 Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family, involved in maintenance of genome integrity ZYRO0E08272g similar to uniprot|P04386 Saccharomyces cerevisiae YPL248C GAL4 DNA-binding transcription factor required for the activation of the GAL genes in response to galactose repressed by Gal80p and activated by Gal3p ZYRO0E08294g weakly similar to uniprot|P42933 Saccharomyces cerevisiae YMR191W SPG5 Protein required for survival at high temperature during stationary phase not required for growth on nonfermentable carbon sources ZYRO0E08316g similar to uniprot|Q12344 Saccharomyces cerevisiae YPL249C GYP5 GTPase-activating protein (GAP) ZYRO0E08338g highly similar to uniprot|P13711 Saccharomyces cerevisiae YGL205W POX1 Fatty-acyl coenzyme A oxidase involved in the fatty acid beta-oxidation pathway localized to the peroxisomal matrix ZYRO0E08360g highly similar to uniprot|P22137 Saccharomyces cerevisiae YGL206C CHC1 vesicle coat protein presumed vesicle coat protein ZYRO0E08382g similar to uniprot|P32558 Saccharomyces cerevisiae YGL207W SPT16 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure ZYRO0E08404g some similarities with uniprot|Q04739 Saccharomyces cerevisiae YER027C GAL83 One of three possible beta-subunits of the Snf1 kinase complex allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source contains glycogen-binding domain and some similarities with YGL208W uniprot|P34164 Saccharomyces cerevisiae YGL208W SIP2 Member of a family of proteins including Sip1p and Gal83p that interact with Snf1p and Snf4p and are involved in the response to glucose starvation component of Snf1 protein complex involved in response to glucose starvation ZYRO0E08426g some similarities with uniprot|P53035 Saccharomyces cerevisiae YGL209W MIG2 Protein containing zinc fingers involved in repression along with Mig1p of SUC2 (invertase) expression by high levels of glucose binds to Mig1p-binding sites in SUC2 promoter ZYRO0E08448g similar to gnl|GLV|CAGL0C02497g Candida glabrata CAGL0C02497g and some similarites with YER029C uniprot|P40018 Saccharomyces cerevisiae YER029C SMB1 associated with U1 U2 U4 and U5 snRNPs as part of the Sm-core that is common to all spliceosomal snRNPs U1 snRNP protein ZYRO0E08470g similar to gnl|GLV|KLLA0B00649g Kluyveromyces lactis KLLA0B00649g and weakly similar to YER030W uniprot|P40019 Saccharomyces cerevisiae YER030W Hypothetical ORF ZYRO0E08492g highly similar to uniprot|P51996 Saccharomyces cerevisiae YGL210W YPT32 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment; ras-like GTPase, highly homologous to YPT31 ZYRO0E08514g some similarities with uniprot|P40020 Saccharomyces cerevisiae YER032W FIR1 Protein involved in 3' mRNA processing interacts with Ref2p potential Cdc28p substrate ZYRO0E08536g weakly similar to uniprot|P40021 Saccharomyces cerevisiae YER033C ZRG8 Cytoplasmic protein of unknown function transcription is induced under conditions of zinc deficiency ZYRO0E08558g highly similar to uniprot|P53088 Saccharomyces cerevisiae YGL211W ZYRO0E08580g similar to uniprot|P32912 Saccharomyces cerevisiae YGL212W VAM7 Regulator of vacuolar morphogenesis hydrophilic protein heptad repeat motif ZYRO0E08602g similar to uniprot|Q02793 Saccharomyces cerevisiae YGL213C SKI8 essential for protection against viral cytopathology dispensable for mitotic but required for meiotic recombination and spore viability antiviral protein mRNA is induced early in meiosis ZYRO0E08624g similar to uniprot|Q2U0T7 Aspergillus oryzae AO090011000310 Predicted protein ZYRO0E08646g weakly similar to uniprot|P35190 Saccharomyces cerevisiae YGL215W CLG1 cyclin-like protein that interacts with Pho85p in affinity chromatography cyclin-like protein that interacts with Pho85 ZYRO0E08668g similar to uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning ZYRO0E08690g similar to uniprot|P53083 Saccharomyces cerevisiae YGL219C MDM34 Mitochondrial outer membrane protein colocalizes with mtDNA nucleids required for mitochondria shape ZYRO0E08712g highly similar to gnl|GLV|CAGL0I06985g Candida glabrata CAGL0I06985g and similar to YGL220W uniprot|P53082 Saccharomyces cerevisiae YGL220W Hypothetical ORF ZYRO0E08734g similar to uniprot|P53081 Saccharomyces cerevisiae YGL221C ZYRO0E08756g similar to uniprot|P40022 Saccharomyces cerevisiae YER034W Hypothetical ORF ZYRO0E08778g weakly similar to uniprot|P53080 Saccharomyces cerevisiae YGL222C ZYRO0E08800g highly similar to uniprot|P40024 Saccharomyces cerevisiae YER036C ZYRO0E08822g weakly similar to uniprot|P53079 Saccharomyces cerevisiae YGL223C COG1 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ZYRO0E08844g similar to uniprot|P53078 Saccharomyces cerevisiae YGL224C SDT1 Pyrimidine nucleotidase overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II as well as resistance to other pyrimidine derivatives or to YER037W uniprot|P40025 Saccharomyces cerevisiae YER037W PHM8 ZYRO0E08866g weakly similar to uniprot|P40026 Saccharomyces cerevisiae YER038C KRE29 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance ZYRO0E08888g similar to uniprot|P40107 Saccharomyces cerevisiae YGL225W VRG4 May regulate Golgi function and glycosylation in Golgi Golgi GDP-mannose transporter ZYRO0E08910g some similarities with uniprot|P18494 Saccharomyces cerevisiae YER040W GLN3 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR) localization and activity regulated by quality of nitrogen source ZYRO0E08932g weakly similar to uniprot|P40028 Saccharomyces cerevisiae YER041W ZYRO0E08954g highly similar to uniprot|P40029 Saccharomyces cerevisiae YER042W MXR1 Peptide methionine sulfoxide reductase reverses the oxidation of methionine residues involved in oxidative damage repair providing resistance to oxidative stress and regulation of lifespan ZYRO0E08976g similar to uniprot|P53077 Saccharomyces cerevisiae YGL226W Hypothetical ORF ZYRO0E08998g similar to uniprot|Q92316 Saccharomyces cerevisiae YGL226C-A OST5 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins ZYRO0E09020g similar to uniprot|Q753T4 Ashbya gossypii AFR242C AFR242Cp and weakly similar to YGL227W uniprot|P53076 Saccharomyces cerevisiae ZYRO0E09042g highly similar to uniprot|P39954 Saccharomyces cerevisiae YER043C SAH1 S-adenosyl-L-homocysteine hydrolase catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor ZYRO0E09064g some similarities with uniprot|P53075 Saccharomyces cerevisiae YGL228W SHE10 Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function overexpression causes growth arrest ZYRO0E09086g weakly similar to uniprot|P43612 Saccharomyces cerevisiae YFR040W ZYRO0E09108g similar to uniprot|P43613 Saccharomyces cerevisiae YFR041C ERJ5 Endoplasmic reticulum protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain ZYRO0E09130g similar to uniprot|P43614 Saccharomyces cerevisiae YFR042W Protein required for cell viability ZYRO0E09152g similar to uniprot|P43615 Saccharomyces cerevisiae YFR043C Hypothetical ORF ZYRO0E09174g no similarity ZYRO0E09196g similar to uniprot|P53073 Saccharomyces cerevisiae YGL231C Hypothetical ORF ZYRO0E09218g similar to uniprot|P53072 Saccharomyces cerevisiae YGL232W TAN1 Putative tRNA acetyltransferase RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA ZYRO0E09240g similar to uniprot|P22224 Saccharomyces cerevisiae YGL233W SEC15 Essential 113kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which mediates polarized targeting of vesicles to active sites of exocytosis Sec15p associates with Sec4p and vesicles ZYRO0E09262g highly similar to uniprot|P43616 Saccharomyces cerevisiae YFR044C Hypothetical ORF ZYRO0E09284g weakly similar to uniprot|P43617 Saccharomyces cerevisiae YFR045W ZYRO0E09306g similar to uniprot|P07244 Saccharomyces cerevisiae YGL234W ADE5 7 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities ZYRO0E09328g highly similar to gnl|GLV|KLLA0A00935g Kluyveromyces lactis KLLA0A00935g and similar to YGL236C uniprot|P53070 Saccharomyces cerevisiae YGL236C MTO1 Mitochondrial protein required for respiration in paromomycin-resistant 15S rRNA mutants forms a heterodimer complex with Mss1p that plays a role in optimizing mitochondrial protein synthesis ZYRO0E09350g weakly similar to uniprot|P43618 Saccharomyces cerevisiae YFR046C CNN1 Kinetochore protein that co-purifies with Nnf1p ZYRO0E09372g some similarities with uniprot|P06774 Saccharomyces cerevisiae YGL237C HAP2 Subunit of the heme-activated glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression contains sequences sufficient for both complex assembly and DNA binding ZYRO0E09394g highly similar to uniprot|P33307 Saccharomyces cerevisiae YGL238W CSE1 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p) homolog of metazoan CAS protein required for accurate chromosome segregation ZYRO0E09416g similar to uniprot|P53068 Saccharomyces cerevisiae YGL240W DOC1 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC) mediates the activity of the APC by contributing to substrate recognition involved in cyclin proteolysis ZYRO0E09438g highly similar to uniprot|P43619 Saccharomyces cerevisiae YFR047C BNA6 Quinolinate phosphoribosyl transferase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway ZYRO0E09460g similar to uniprot|P53067 Saccharomyces cerevisiae YGL241W ZYRO0E09482g highly similar to uniprot|P53066 Saccharomyces cerevisiae YGL242C Hypothetical ORF ZYRO0E09504g similar to uniprot|P53065 Saccharomyces cerevisiae YGL243W TAD1 tRNA-specific adenosine deaminase deaminates adenosine-37 to inosine in tRNA-Ala ZYRO0E09526g similar to uniprot|P53064 Saccharomyces cerevisiae YGL244W RTF1 Subunit of the RNA polymerase II-associated Paf1 complex directly or indirectly regulates DNA-binding properties of Spt15p (TATA box-binding protein) and relative activities of different TATA elements ZYRO0E09548g similar to uniprot|P43620 Saccharomyces cerevisiae YFR048W RMD8 Cytosolic protein required for sporulation ZYRO0E09570g highly similar to uniprot|P46655 Saccharomyces cerevisiae YGL245W GUS1 Glutamyl-tRNA synthetase (GluRS) forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm ZYRO0E09592g similar to uniprot|P53063 Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p required for pre-rRNA processing ZYRO0E09614g similar to uniprot|Q07551 Saccharomyces cerevisiae YDL124W NADPH-dependent alpha-keto amide reductase reduces aromatic alpha-keto amides aliphatic alpha-keto esters and aromatic alpha-keto esters ZYRO0E09636g some similarities with uniprot|P53062 Saccharomyces cerevisiae YGL247W BRR6 Essential nuclear envelope integral membrane protein required for nuclear transport depletion alters nucleoporin distribution and nuclear envelope morphology suggesting a role in the spatial organization of nuclear pores ZYRO0E09680g similar to uniprot|P19955 Saccharomyces cerevisiae YFR049W ZYRO0E09702g similar to uniprot|P22434 Saccharomyces cerevisiae YGL248W PDE1 Low-affinity cyclic AMP phosphodiesterase controls glucose and intracellular acidification-induced cAMP signaling target of the cAMP-protein kinase A (PKA) pathway glucose induces transcription and inhibits translation ZYRO0E09724g highly similar to uniprot|P30657 Saccharomyces cerevisiae YFR050C PRE4 20S proteasome beta-type subunit ZYRO0E09746g similar to uniprot|P43621 Saccharomyces cerevisiae YFR051C RET2 Delta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER ZYRO0E09768g weakly similar to uniprot|P53061 Saccharomyces cerevisiae YGL249W ZIP2 Required for 'ZIPpering' up meiotic chromosomes during chromosome synapsis involved in meiotic recombination and disjunction ZYRO0E09790g similar to uniprot|P53060 Saccharomyces cerevisiae YGL250W Hypothetical ORF ZYRO0E09812g similar to uniprot|P51979 Saccharomyces cerevisiae YGL251C HFM1 Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control catalyzes the unwinding of Holliday junctions has ssDNA and dsDNA stimulated ATPase activity ZYRO0E09834g highly similar to uniprot|P32608 Saccharomyces cerevisiae YGL252C RTG2 Sensor of mitochondrial dysfunction regulates the subcellular location of Rtg1p and Rtg3p transcriptional activators of the retrograde (RTG) and TOR pathways Rtg2p is inhibited by the phosphorylated form of Mks1p ZYRO0E09856g highly similar to gnl|GLV|CAGL0A04807g Candida glabrata CAGL0A04807g and similar to YFR052W uniprot|P32496 Saccharomyces cerevisiae YFR052W RPN12 Subunit of the 19S regulatory particle of the 26S proteasome lid synthetically lethal with RPT1 which is an ATPase component of the 19S regulatory particle physically interacts with Nob1p and Rpn3p ZYRO0E09878g highly similar to uniprot|P04807 Saccharomyces cerevisiae YGL253W HXK2 Hexokinase isoenzyme 2 catalyzes phosphorylation of glucose in the cytosol predominate hexokinase during growth on glucose functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene ZYRO0E09900g similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs ZYRO0E09922g similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs ZYRO0E09966g similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs ZYRO0E09988g similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs ZYRO0E10032g similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase ZYRO0E10054g similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Proton-motive-force- dependent multidrug transporter of the major facilitator superfamily able to transport eight different compounds including polyamines quinidine cycloheximide and nystatin involved in excess spermidine detoxification ZYRO0E10142g similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF ZYRO0E10230g weakly similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Proton- motive-force-dependent multidrug transporter of the major facilitator superfamily able to transport eight different compounds including polyamines quinidine cycloheximide and nystatin involved in excess spermidine detoxification ZYRO0E10252g some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization ZYRO0E10296g no similarity ZYRO0E10318g highly similar to uniprot|P15202 Saccharomyces cerevisiae YDR256C CTA1 Catalase A breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation ZYRO0E10340g highly similar to uniprot|Q2UD26 Aspergillus oryzae AO090012000349 Choline dehydrogenase and related flavoproteins ZYRO0E10362g similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W ZYRO0E10406g similar to uniprot|P33751 Saccharomyces cerevisiae YDR538W PAD1 Phenylacrylic acid decarboxylase confers resistance to cinnamic acid decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives ZYRO0E10428g similar to uniprot|Q03034 Saccharomyces cerevisiae YDR539W Hypothetical ORF ZYRO0E10450g some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments ZYRO0F00176g weakly similar to uniprot|P32768 Saccharomyces cerevisiae YAR050W ZYRO0F00242g similar to uniprot|Q0CZS0 Aspergillus terreus NIH2624 ATEG_00814 Hypothetical protein ZYRO0F00264g similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C ZYRO0F00286g similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 similar to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase ZYRO0F00308g highly similar to uniprot|P41819 Saccharomyces cerevisiae YPL266W DIM1 Essential 18S rRNA dimethylase responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA part of 90S and 40S pre-particles in nucleolus involved in pre-ribosomal RNA processing ZYRO0F00330g similar to uniprot|Q08981 Saccharomyces cerevisiae YPL267W ACM1 Protein of unknown function potential Cdc28p substrate ZYRO0F00352g similar to uniprot|P32383 Saccharomyces cerevisiae YPL268W PLC1 Phosphoinositide-specific phospholipase C hydrolyzes phosphatidylinositol 4 5-biphosphate (PIP2) to generate inositol 1 4 5-triphosphate (IP3) and 1 2-diacylglycerol (DAG) involved in kinetochore function and pseudohyphal differentiation ZYRO0F00374g similar to gnl|GLV|CAGL0A01155g Candida glabrata CAGL0A01155g and weakly similar to YPL269W uniprot|P32526 Saccharomyces cerevisiae YPL269W KAR9 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase ZYRO0F00396g similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane ZYRO0F00418g similar to uniprot|P21306 Saccharomyces cerevisiae YPL271W ATP15 Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis ZYRO0F00440g similar to gnl|GLV|CAGL0B03553g Candida glabrata CAGL0B03553g and weakly similar to YEL055C uniprot|P39985 Saccharomyces cerevisiae ZYRO0F00462g similar to uniprot|P39984 Saccharomyces cerevisiae YEL056W ZYRO0F00484g similar to uniprot|Q08979 Saccharomyces cerevisiae YPL263C KEL3 Cytoplasmic protein of unknown function ZYRO0F00506g similar to uniprot|P38628 Saccharomyces cerevisiae YEL058W PCM1 Essential N-acetylglucosamine-phosphate mutase a hexosephosphate mutase involved in the biosynthesis of chitin ZYRO0F00528g similar to uniprot|Q05676 Saccharomyces cerevisiae YEL059C-A ZYRO0F00550g similar to uniprot|Q06674 Saccharomyces cerevisiae YDR317W Hypothetical ORF ZYRO0F00616g similar to uniprot|Q04660 Saccharomyces cerevisiae YMR049C ERB1 Protein required for maturation of the 25S and 5.8S ribosomal RNAs homologous to mammalian Bop1 ZYRO0F00638g some similarities with uniprot|Q04659 Saccharomyces cerevisiae YMR048W CSM3 Protein required for accurate chromosome segregation during meiosis ZYRO0F00660g some similarities with uniprot|Q02630 Saccharomyces cerevisiae YMR047C NUP116 Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p homologous to Nup100p ZYRO0F00704g weakly similar to uniprot|Q04213 Saccharomyces cerevisiae YMR044W IOC4 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing contains a PWWP motif ZYRO0F00726g similar to uniprot|Q75DC9 Ashbya gossypii ABR098C ABR098Cp and some similarites with YMR043W uniprot|P11746 Saccharomyces cerevisiae YMR043W MCM1 Transcription factor involved in cell-type-specific transcription and pheromone response plays a central role in the formation of both repressor and activator complexes ZYRO0F00748g similar to uniprot|P07249 Saccharomyces cerevisiae YMR042W ARG80 Transcription factor involved in regulation of arginine-responsive genes acts with Arg81p and Arg82p ZYRO0F00814g highly similar to uniprot|P36010 Saccharomyces cerevisiae YKL067W YNK1 Nucleoside diphosphate kinase catalyzes the phosphorylation of nucleoside diphosphates into the corresponding triphosphates for nucleic acid biosynthesis ZYRO0F00836g conserved hypothetical protein ZYRO0F00858g similar to uniprot|Q04212 Saccharomyces cerevisiae YMR041C Hypothetical ORF ZYRO0F00880g similar to uniprot|P35723 Saccharomyces cerevisiae YKL065C YET1 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein ZYRO0F00902g similar to uniprot|P54000 Saccharomyces cerevisiae YMR039C SUB1 Suppressor of TFIIB mutations transcriptional coactivator ZYRO0F00924g similar to uniprot|P35724 Saccharomyces cerevisiae YKL064W ZYRO0F00946g similar to uniprot|P40202 Saccharomyces cerevisiae YMR038C CCS1 Copper chaperone for superoxide dismutase Sod1p involved in oxidative stress protection Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation ZYRO0F00968g weakly similar to uniprot|P35725 Saccharomyces cerevisiae YKL063C Hypothetical ORF ZYRO0F01012g similar to uniprot|P33749 Saccharomyces cerevisiae YKL062W MSN4 Transcriptional activator related to Msn2p activated in stress conditions which results in translocation from the cytoplasm to the nucleus binds DNA at stress response elements of responsive genes inducing gene expression ZYRO0F01034g similar to uniprot|P32801 Saccharomyces cerevisiae YKL048C ELM1 Serine/threonine protein kinase that regulates cellular morphogenesis septin behavior and cytokinesis required for the regulation of other kinases forms part of the bud neck ring ZYRO0F01056g some similarities with uniprot|P23748 Saccharomyces cerevisiae YMR036C MIH1 Protein tyrosine phosphatase involved in cell cycle control regulates the phosphorylation state of Cdc28p homolog of S. pombe cdc25 ZYRO0F01078g highly similar to uniprot|P46972 Saccharomyces cerevisiae YMR035W IMP2 mitochondrial peptidase ZYRO0F01100g similar to uniprot|Q05131 Saccharomyces cerevisiae YMR034C Hypothetical ORF ZYRO0F01122g similar to uniprot|Q05123 Saccharomyces cerevisiae YMR033W ARP9 Actin-related protein involved in transcriptional regulation; subunit of the chromatin remodeling Snf/Swi complex ZYRO0F01144g highly similar to uniprot|P36012 Saccharomyces cerevisiae YKL049C CSE4 Centromere protein that resembles histones required for proper kinetochore function homolog of human CENP-A ZYRO0F01166g similar to uniprot|Q05080 Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized SH3 domain-containing protein required for cytokinesis ZYRO0F01188g similar to uniprot|Q05050 Saccharomyces cerevisiae YMR031C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0F01210g similar to uniprot|P35735 Saccharomyces cerevisiae YKL051W ZYRO0F01232g some similarities with uniprot|P35734 Saccharomyces cerevisiae YKL052C ASK1 Component of the DASH complex that binds to microtubules and kinetochores and is essential for chromosome segregation phosphorylated during the cell cycle by cyclin-dependent kinases ZYRO0F01254g similar to uniprot|P28817 YDR036C Saccharomyces cerevisiae EHD3 Protein of unconfirmed function plays an indirect role in endocytic membrane trafficking member of a family of enoyl-CoA hydratase/isomerases ZYRO0F01276g similar to uniprot|P38237 YBR058C Saccharomyces cerevisiae UBP14 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains ZYRO0F01298g similar to uniprot|P38236 YBR057C Saccharomyces cerevisiae MUM2 Cytoplasmic protein essential for meiotic DNA replication and sporulation ZYRO0F01320g highly similar to uniprot|P14843 YDR035W Saccharomyces cerevisiae ARO3 3-deoxy-D-arabino-heptulosonate-7- phosphate (DAHP) synthase ZYRO0F01364g similar to uniprot|P38081 YBR056W Saccharomyces cerevisiae Hypothetical ORF ZYRO0F01408g similar to uniprot|P32495 Saccharomyces cerevisiae YDL208W NHP2 Nuclear protein related to mammalian high mobility group (HMG) proteins essential for function of H/ACA-type snoRNPs which are involved in 18S rRNA processing ZYRO0F01430g similar to uniprot|Q03782 Saccharomyces cerevisiae YDR240C SNU56 U1 snRNP protein serine-rich has no counterpart in mammalian U1 snRNP ZYRO0F01452g weakly similar to uniprot|Q03780 Saccharomyces cerevisiae YDR239C Hypothetical ORF ZYRO0F01474g highly similar to uniprot|P41810 Saccharomyces cerevisiae YDR238C SEC26 Involved in endoplasmic-to-Golgi protein trafficking encodes a subunit of yeast coatomer ZYRO0F01496g highly similar to uniprot|P32905 Saccharomyces cerevisiae YGR214W RPS0A protein component of the small (40S) ribosomal subunit ZYRO0F01518g similar to uniprot|Q12209 Saccharomyces cerevisiae YLR047C Hypothetical ORF ZYRO0F01540g similar to uniprot|P53304 Saccharomyces cerevisiae YGR212W SLI1 N-acetyltransferase confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by inactivating it co-operates with Ypk1p in mediating resistance to myriocin converts myriocin into N-acetyl-myriocin ZYRO0F01562g highly similar to uniprot|P53303 Saccharomyces cerevisiae YGR211W ZPR1 Essential protein with two zinc fingers present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p binds to translation elongation factor eEF-1 (Tef1p) ZYRO0F01584g highly similar to uniprot|P42942 Saccharomyces cerevisiae YGR210C Hypothetical ORF ZYRO0F01606g highly similar to uniprot|P06169 Saccharomyces cerevisiae YLR044C PDC1 Major of three pyruvate decarboxylase isozymes key enzyme in alcoholic fermentation decarboxylates pyruvate to acetaldehyde subject to glucose-ethanol- and autoregulation involved in amino acid catabolism and to YLR134W uniprot|P16467 Saccharomyces cerevisiae YLR134W PDC5 Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism ZYRO0F01628g similar to uniprot|P46675 Saccharomyces cerevisiae YLR045C STU2 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment interacts with spindle pole body component Spc72p ZYRO0F01650g highly similar to gnl|GLV|CAGL0K00803g Candida glabrata CAGL0K00803g and similar to YLR043C uniprot|P22217 Saccharomyces cerevisiae YLR043C TRX1 thioredoxin ZYRO0F01672g similar to uniprot|P42941 Saccharomyces cerevisiae YGR208W SER2 phosphoserine phosphatase ZYRO0F01694g similar to uniprot|P53039 Saccharomyces cerevisiae YGR172C YIP1 Golgi integral membrane protein binds to the transport GTPases Ypt1p and Ypt31p ZYRO0F01716g similar to uniprot|P22438 Saccharomyces cerevisiae YGR171C MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p ZYRO0F01738g similar to uniprot|P46957 Saccharomyces cerevisiae YJR006W HYS2 DNA polymerase III (delta) 55 kDa subunit essential for cell viability involved in DNA replication and DNA repair ZYRO0F01760g similar to uniprot|P53037 Saccharomyces cerevisiae YGR170W PSD2 Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes converts phosphatidylserine to phosphatidylethanolamine ZYRO0F01782g weakly similar to uniprot|P36119 Saccharomyces cerevisiae YKR023W Hypothetical ORF ZYRO0F01804g similar to uniprot|P42950 Saccharomyces cerevisiae YJL103C Hypothetical ORF ZYRO0F01826g similar to uniprot|P36120 Saccharomyces cerevisiae YKR024C DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis ZYRO0F01848g similar to uniprot|P36121 Saccharomyces cerevisiae YKR025W RPC37 RNA polymerase III subunit C37 ZYRO0F01870g highly similar to uniprot|P14741 Saccharomyces cerevisiae YKR026C GCN3 Alpha subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a positive regulator of GCN4 expression ZYRO0F01892g similar to uniprot|P39677 Saccharomyces cerevisiae YJL102W MEF2 mitochondrial elongation factor G-like protein ZYRO0F01936g similar to uniprot|P32477 Saccharomyces cerevisiae YJL101C GSH1 Gamma glutamylcysteine synthetase catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis expression induced by oxidants cadmium and mercury ZYRO0F01958g similar to uniprot|P42951 Saccharomyces cerevisiae YJL100W LSB6 Phosphatidylinositol 4-kinase that binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization ZYRO0F01980g similar to uniprot|P36122 Saccharomyces cerevisiae YKR027W FMP50 The authentic non-tagged protein was localized to the mitochondria and uniprot|P40955 Saccharomyces cerevisiae YJL099w CHS6 chitin biosynthesis protein ZYRO0F02002g conserved hypothetical protein ZYRO0F02024g some similarities with uniprot|P43550 Saccharomyces cerevisiae YFL053W DAK2 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation ZYRO0F02046g no similarity ZYRO0F02068g conserved hypothetical protein ZYRO0F02090g similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Proton-motive-force- dependent multidrug transporter of the major facilitator superfamily able to transport eight different compounds including polyamines quinidine cycloheximide and nystatin involved in excess spermidine detoxification ZYRO0F02112g weakly similar to uniprot|Q08909 Saccharomyces cerevisiae YOR385W Hypothetical ORF ZYRO0F02134g weakly similar to uniprot|Q08909 Saccharomyces cerevisiae YOR385W Hypothetical ORF ZYRO0F02156g weakly similar to uniprot|Q08909 Saccharomyces cerevisiae YOR385W Hypothetical ORF ZYRO0F02178g similar to gnl|GLV|DEHA0A14894g Debaryomyces hansenii DEHA0A14894g and weakly similar to YLL028W uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Proton- motive-force-dependent multidrug transporter of the major facilitator superfamily able to transport eight different compounds including polyamines quinidine cycloheximide and nystatin involved in excess spermidine detoxification ZYRO0F02200g similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane responsible for the majority of zinc uptake transcription is induced under low-zinc conditions by the Zap1p transcription factor ZYRO0F02222g similar to uniprot|Q03102 Saccharomyces cerevisiae YML131W Hypothetical ORF ZYRO0F02244g similar to uniprot|P43554 Saccharomyces cerevisiae YFL049W Hypothetical ORF ZYRO0F02266g similar to uniprot|P43555 Saccharomyces cerevisiae YFL048C EMP47 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport ZYRO0F02288g conserved hypothetical protein ZYRO0F02310g similar to uniprot|P43556 Saccharomyces cerevisiae YFL047W RGD2 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p ZYRO0F02332g weakly similar to uniprot|P38634 Saccharomyces cerevisiae YLR079W SIC1 P40 inhibitor of Cdc28p-Clb5p protein kinase complex ZYRO0F02354g similar to uniprot|P25385 Saccharomyces cerevisiae YLR078C BOS1 v-SNARE (vesicle specific SNAP receptor) localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi ZYRO0F02376g similar to uniprot|Q7LI62 Saccharomyces cerevisiae YLR077W FMP25 The authentic non-tagged protein was localized to the mitochondria ZYRO0F02398g highly similar to uniprot|P43557 Saccharomyces cerevisiae YFL046W FMP32 The authentic non-tagged protein was localized to the mitochondria ZYRO0F02420g highly similar to uniprot|P07283 Saccharomyces cerevisiae YFL045C SEC53 involved in synthesis of GDP-mannose and dolichol-phosphate-mannose required for protein assembly in endoplasmic reticulum phosphomannomutase ZYRO0F02442g highly similar to uniprot|P41805 Saccharomyces cerevisiae YLR075W ZYRO0F02464g similar to uniprot|Q08004 Saccharomyces cerevisiae YLR074C BUD20 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ZYRO0F02486g similar to uniprot|P43558 Saccharomyces cerevisiae YFL044C YOD1 Yeast OTU Deubiquitinating enzyme 1 ZYRO0F02508g similar to uniprot|P43560 Saccharomyces cerevisiae YFL042C Due to a sequence change (deletion of G at 46151) YFL043C is now part of YFL042C. ZYRO0F02530g similar to uniprot|P19263 Saccharomyces cerevisiae YLR071C RGR1 Component of RNA polymerase II holoenzyme/mediator complex affects chromatin structure and transcriptional regulation of diverse genes required for glucose repression HO repression RME1 repression and sporulation ZYRO0F02552g similar to uniprot|Q07786 Saccharomyces cerevisiae YDL246C SOR2 Protein of unknown function computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism ZYRO0F02574g similar to uniprot|P43561 Saccharomyces cerevisiae YFL041W ZYRO0F02596g highly similar to uniprot|P25039 Saccharomyces cerevisiae YLR069C MEF1 mitochondrial elongation factor G-like protein ZYRO0F02618g similar to uniprot|Q12247 Saccharomyces cerevisiae YLR068W FYV7 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts ZYRO0F02640g weakly similar to uniprot|P47068 Saccharomyces cerevisiae YJL020C BBC1 Protein possibly involved in assembly of actin patches interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p localized predominantly to cortical actin patches ZYRO0F02662g similar to uniprot|P32522 Saccharomyces cerevisiae YLR067C PET309 Specific translational activator for the COX1 mRNA also influences stability of intron-containing COX1 primary transcripts located in the mitochondrial inner membrane ZYRO0F02684g similar to uniprot|Q12133 Saccharomyces cerevisiae YLR066W SPC3 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC22/23 ZYRO0F02706g similar to gnl|GLV|CAGL0K12716g Candida glabrata CAGL0K12716g and weakly similar to YFL040W uniprot|P43562 Saccharomyces cerevisiae YFL040W Hypothetical ORF ZYRO0F02728g some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) ZYRO0F02750g some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) ZYRO0F02772g uniprot|Q2HWE7 Zygosaccharomyces rouxii ACT1 Actin ZYRO0F02794g similar to uniprot|Q6Q5C1 Saccharomyces cerevisiae YLR065C Hypothetical ORF ZYRO0F02816g highly similar to uniprot|P01123 Saccharomyces cerevisiae YFL038C YPT1 Ras-like small GTPase involved in the ER-to-Golgi step of the secretory pathway complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) ZYRO0F02838g similar to uniprot|Q12144 Saccharomyces cerevisiae YLR064W Hypothetical ORF ZYRO0F02860g highly similar to uniprot|P02557 Saccharomyces cerevisiae YFL037W TUB2 Beta-tubulin associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer which polymerizes to form microtubules ZYRO0F02882g similar to uniprot|P13433 Saccharomyces cerevisiae YFL036W ZYRO0F02904g similar to uniprot|P43563 Saccharomyces cerevisiae YFL034C-B MOB2 Component of the RAM signaling network localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation Mob1p-like protein ZYRO0F02926g similar to uniprot|Q12291 Saccharomyces cerevisiae YLR063W Hypothetical ORF ZYRO0F02948g highly similar to gnl|GLV|CAGL0F01683g Candida glabrata CAGL0F01683g and highly similar to YLR061W uniprot|P05749 Saccharomyces cerevisiae ZYRO0F02970g similar to uniprot|P43564 Saccharomyces cerevisiae YFL034W Possible integral membrane protein that interacts with Rpp0p which is a component of the ribosomal stalk ZYRO0F02992g highly similar to uniprot|P15624 Saccharomyces cerevisiae YLR060W ZYRO0F03014g similar to uniprot|Q75BQ3 Ashbya gossypii ACR218W ACR218Wp and some similarites with YFL033C uniprot|P43565 Saccharomyces cerevisiae YFL033C RIM15 Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients specifically the establishment of stationary phase originally identified as a regulator of IME2 ZYRO0F03036g similar to uniprot|P54964 Saccharomyces cerevisiae YLR059C REX2 RNA exonuclease required for U4 snRNA maturation functions redundantly with Rnh70p in 5.8S rRNA maturation and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA member of RNase D family of exonucleases ZYRO0F03058g conserved hypothetical protein ZYRO0F03102g some similarities with uniprot|P41546 Saccharomyces cerevisiae YFL031W HAC1 bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response via UPRE binding and membrane biogenesis ER stress-induced splicing pathway utilizing Ire1p Trl1p and Ada5p facilitates efficient Hac1p synthesis ZYRO0F03124g similar to uniprot|P43567 Saccharomyces cerevisiae YFL030W ZYRO0F03146g highly similar to uniprot|P37291 Saccharomyces cerevisiae YLR058C SHM2 serine hydroxymethyltransferase ZYRO0F03168g similar to uniprot|Q7LGY1 Saccharomyces cerevisiae YLR057W Hypothetical ORF ZYRO0F03190g similar to uniprot|P43568 Saccharomyces cerevisiae YFL029C CAK1 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle phosphorylates and activates Cdc28p nucleotide-binding pocket differs significantly from those of most other protein kinases ZYRO0F03212g highly similar to uniprot|P32353 Saccharomyces cerevisiae YLR056W ERG3 C-5 sterol desaturase catalyzes the introduction of a C-5(6) double bond into episterol a precursor in ergosterol biosynthesis mutants are viable but cannot grow on non-fermentable carbon sources ZYRO0F03234g similar to uniprot|P43569 Saccharomyces cerevisiae YFL028C CAF16 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation putative ABC ATPase interacts with Ssn2p Ssn3p and Ssn8p ZYRO0F03256g similar to uniprot|P38915 Saccharomyces cerevisiae YLR055C SPT8 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA required for SAGA-mediated inhibition at some promoters ZYRO0F03278g similar to uniprot|P43570 Saccharomyces cerevisiae YFL027C GYP8 GTPase-activating protein for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p Ypt31p and Ypt32p involved in the regulation of ER to Golgi vesicle transport ZYRO0F03300g similar to uniprot|P06842 Saccharomyces cerevisiae YFL026W STE2 Receptor for alpha-factor pheromone seven transmembrane-domain protein that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells ZYRO0F03322g similar to uniprot|P43571 Saccharomyces cerevisiae YFL025C BST1 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation prevents production of vesicles with defective subunits required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules ZYRO0F03344g similar to uniprot|P43572 Saccharomyces cerevisiae YFL024C EPL1 Component of NuA4 which is an essential histone H4/H2A acetyltransferase complex homologous to Drosophila Enhancer of Polycomb ZYRO0F03366g similar to uniprot|P43573 Saccharomyces cerevisiae YFL023W BUD27 Protein involved in bud-site selection nutrient signaling and gene expression controlled by the TOR kinase diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ZYRO0F03388g conserved hypothetical protein ZYRO0F03410g some similarities with uniprot|Q12202 Saccharomyces cerevisiae YLR054C OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall ZYRO0F03432g no similarity ZYRO0F03454g highly similar to uniprot|P15625 Saccharomyces cerevisiae YFL022C ZYRO0F03476g similar to uniprot|Q12345 Saccharomyces cerevisiae YLR052W IES3 Subunit of the INO80 chromatin remodeling complex ZYRO0F03498g similar to uniprot|Q12035 Saccharomyces cerevisiae YLR051C Protein required for cell viability ZYRO0F03520g uniprot|P87016 Zygosaccharomyces rouxii SAT1 DNA-binding protein ZYRO0F03542g highly similar to uniprot|P09624 Saccharomyces cerevisiae YFL018C LPD1 Dihydrolipoamide dehydrogenase the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes ZYRO0F03564g highly similar to uniprot|P40204 Saccharomyces cerevisiae YFL017W-A SMX2 snRNP G protein (the homologue of the human Sm-G) ZYRO0F03586g similar to uniprot|P43577 Saccharomyces cerevisiae YFL017C GNA1 Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START DNA synthesis and mitosis involved in UDP-N-acetylglucosamine synthesis forms GlcNAc6P from AcCoA ZYRO0F03608g weakly similar to uniprot|Q12110 Saccharomyces cerevisiae YLR049C Hypothetical ORF ZYRO0F03630g similar to uniprot|Q12155 Saccharomyces cerevisiae YLR050C Hypothetical ORF ZYRO0F03652g similar to uniprot|Q752R6 Ashbya gossypii AFR507W AFR507Wp and some similarites with YFL016C uniprot|P35191 Saccharomyces cerevisiae YFL016C MDJ1 Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix localizes to the mitochondrial inner membrane member of the DnaJ family of molecular chaperones ZYRO0F03674g weakly similar to uniprot|P38276 Saccharomyces cerevisiae YBR137W Hypothetical ORF ZYRO0F03696g similar to uniprot|P22943 Saccharomyces cerevisiae YFL014W HSP12 Plasma membrane localized protein that protects membranes from desiccation induced by heat shock oxidative stress osmostress stationary phase entry glucose depletion oleate and alcohol regulated by the HOG and Ras-Pka pathways ZYRO0F03718g weakly similar to uniprot|Q02732 Saccharomyces cerevisiae YPL018W CTF19 Outer kinetochore protein required for accurate mitotic chromosome segregation forms a complex with Mcm21p and Okp1p that binds to centromeres via the CBF3 complex ZYRO0F03740g similar to uniprot|P43579 Saccharomyces cerevisiae YFL013C IES1 Subunit of the INO80 chromatin remodeling complex ZYRO0F03762g weakly similar to uniprot|P43582 Saccharomyces cerevisiae YFL010C WWM1 WW domain containing protein interacting with Metacaspase (MCA1) ZYRO0F03784g similar to uniprot|P07834 Saccharomyces cerevisiae YFL009W CDC4 F-box protein required for G1/S and G2/M transition associates with Skp1p and Cdc53p to form a complex SCFCdc4 which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p ZYRO0F03806g conserved hypothetical protein ZYRO0F03828g similar to uniprot|P32908 Saccharomyces cerevisiae YFL008W SMC1 Subunit of the multiprotein cohesin complex essential protein involved in chromosome segregation and in double-strand DNA break repair SMC chromosomal ATPase family member binds DNA with a preference for DNA with secondary structure ZYRO0F03850g similar to uniprot|P43583 Saccharomyces cerevisiae YFL007W BLM3 Protein involved in assembly of proteasomal core particles in the nucleus required for normal resistance to bleomycin may be involved in protection against oxidative damage ZYRO0F03872g highly similar to uniprot|P07560 Saccharomyces cerevisiae YFL005W SEC4 Secretory vesicle-associated Rab GTPase essential for exocytosis associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane ZYRO0F03894g similar to uniprot|P43585 Saccharomyces cerevisiae YFL004W VTC2 Phosphate metabolism transcription and similar to uniprot|Q02725 Saccharomyces cerevisiae YPL019C VTC3 ZYRO0F03916g similar to uniprot|Q02724 Saccharomyces cerevisiae YPL020C ULP1 Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates specifically required for cell cycle progression associates with nucleoporins and may interact with septin rings during telophase ZYRO0F03938g similar to uniprot|P40965 Saccharomyces cerevisiae YFL003C MSH4 Protein involved in meiotic recombination required for normal levels of crossing over colocalizes with Zip2p to discrete foci on meiotic chromosomes has homology to bacterial MutS protein ZYRO0F03960g similar to uniprot|P53686 Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD()-dependent protein deacetylases modulates nucleolar (rDNA) and telomeric silencing possesses NAD()-dependent histone deacetylase activity in vitro ZYRO0F04004g similar to uniprot|Q12532 Saccharomyces cerevisiae YPL009C Hypothetical ORF ZYRO0F04026g highly similar to uniprot|P53600 Saccharomyces cerevisiae YPL010W RET3 Zeta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER ZYRO0F04048g similar to uniprot|Q12297 Saccharomyces cerevisiae YPL011C TAF3 TFIID subunit (47 kDa) involved in promoter binding and RNA polymerase II transcription initiation ZYRO0F04070g similar to uniprot|Q7LH12 Saccharomyces cerevisiae YPL012W RRP12 Protein required for normal pre-rRNA Processing member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift ZYRO0F04092g highly similar to gnl|GLV|KLLA0F27247g Kluyveromyces lactis KLLA0F27247g and similar to YPL013C uniprot|Q02608 Saccharomyces cerevisiae YPL013C MRPS16 Mitochondrial ribosomal protein of the small subunit ZYRO0F04114g weakly similar to uniprot|Q02606 Saccharomyces cerevisiae YPL014W Hypothetical ORF ZYRO0F04136g similar to uniprot|P22516 Saccharomyces cerevisiae YPL008W ZYRO0F04158g similar to uniprot|Q12308 Saccharomyces cerevisiae YPL007C TFC8 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes linker between TauB and TauA domains human homolog is TFIIIC-90 ZYRO0F04180g similar to uniprot|Q12200 Saccharomyces cerevisiae YPL006W NCR1 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway involved in sphingolipid metabolism glycoprotein homologous to human Niemann Pick C1 (NPC) protein ZYRO0F04202g similar to uniprot|Q12089 Saccharomyces cerevisiae YPL005W AEP3 Peripheral mitochondrial inner membrane protein located on the matrix face of the membrane stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex ZYRO0F04224g highly similar to uniprot|Q12230 Saccharomyces cerevisiae YPL004C LSP1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Pil1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p ZYRO0F04246g highly similar to uniprot|P13298 Saccharomyces cerevisiae YML106W URA5 Fifth step in pyrimidine biosynthesis pathway Orotate phosphoribosyltransferase 1 ZYRO0F04268g no similarity ZYRO0F04290g similar to uniprot|Q12059 Saccharomyces cerevisiae YPL003W ULA1 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation ZYRO0F04312g highly similar to uniprot|P25808 Saccharomyces cerevisiae YFL002C SPB4 involved in the maturation of 25S ribosomal RNA ATP-dependent RNA helicase ZYRO0F04334g similar to uniprot|P31115 Saccharomyces cerevisiae YFL001W DEG1 Non-essential tRNA:pseudouridine synthase introduces pseudouridines at position 38 or 39 in tRNA important for maintenance of translation efficiency and normal cell growth localizes to both the nucleus and cytoplasm ZYRO0F04356g highly similar to uniprot|Q12483 Saccharomyces cerevisiae YPL002C SNF8 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome appears to be functionally related to SNF7 involved in glucose derepression ZYRO0F04378g similar to uniprot|Q12341 Saccharomyces cerevisiae YPL001W HAT1 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4 involved in telomeric silencing and DNA double-strand break repair ZYRO0F04422g similar to uniprot|P43586 Saccharomyces cerevisiae YFR001W LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA binds double-stranded RNA in vitro ZYRO0F04444g similar to uniprot|P43635 Saccharomyces cerevisiae YPR001W CIT3 Citrate synthase catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate mitochondrial isozyme involved in the TCA cycle ZYRO0F04466g similar to uniprot|Q12428 Saccharomyces cerevisiae YPR002W PDH1 Mitochondrial protein that participates in respiration induced by diauxic shift homologous to E. coli PrpD may take part in the conversion of 2-methylcitrate to 2-methylisocitrate ZYRO0F04488g similar to uniprot|P34077 Saccharomyces cerevisiae YFR002W NIC96 Component of the nuclear pore complex required for nuclear pore formation forms a subcomplex with Nsp1p Nup57p and Nup49p ZYRO0F04510g weakly similar to uniprot|P43587 Saccharomyces cerevisiae YFR003C YPI1 Inhibitor of the type I protein phosphatase Glc7p which is involved in regulation of a variety of metabolic processes overproduction causes decreased cellular content of glycogen ZYRO0F04532g highly similar to uniprot|P43588 Saccharomyces cerevisiae YFR004W RPN11 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid couples the deubiquitination and degradation of proteasome substrates ZYRO0F04554g similar to uniprot|P43589 Saccharomyces cerevisiae YFR005C SAD1 Conserved zinc-finger domain protein involved in pre-mRNA splicing required for assembly of U4 snRNA into the U4/U6 particle ZYRO0F04576g similar to uniprot|P43590 Saccharomyces cerevisiae YFR006W Hypothetical ORF ZYRO0F04620g no similarity ZYRO0F04642g similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs ZYRO0F04664g similar to uniprot|P43592 Saccharomyces cerevisiae YFR008W FAR7 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far8p Far9p Far10p and Far11p ZYRO0F04686g similar to uniprot|Q12188 Saccharomyces cerevisiae YPR007C REC8 Meiosis-specific component of sister chromatid cohesion complex maintains cohesion between sister chromatids during meiosis I maintains cohesion between centromeres of sister chromatids until meiosis II homolog of S. pombe Rec8p ZYRO0F04708g similar to uniprot|Q12031 Saccharomyces cerevisiae YPR006C ICL2 2-methylisocitrate lyase of the mitochondrial matrix functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate ICL2 transcription is repressed by glucose and induced by ethanol ZYRO0F04730g no similarity ZYRO0F04752g similar to uniprot|P43591 Saccharomyces cerevisiae YFR007W Hypothetical ORF ZYRO0F04774g similar to uniprot|Q12480 Saccharomyces cerevisiae YPR004C Hypothetical ORF ZYRO0F04796g similar to uniprot|P53394 Saccharomyces cerevisiae YPR003C Hypothetical ORF ZYRO0F04818g no similarity ZYRO0F04840g highly similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance ZYRO0F04862g weakly similar to uniprot|Q12753 Saccharomyces cerevisiae YPR008W ZYRO0F04884g similar to uniprot|P53107 Saccharomyces cerevisiae YGL164C YRB30 Competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) able to form trimeric complexes with RanGTP and some of the karyopherins inhibits RanGAP1(Rna1p)-mediated GTP hydrolysis on Ran. ZYRO0F04906g highly similar to uniprot|P32863 Saccharomyces cerevisiae YGL163C RAD54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis member of the SWI/SNF family ZYRO0F04928g some similarities with uniprot|Q12286 Saccharomyces cerevisiae YPR009W SUT2 Involved in sterol uptake homologous to SUT1 ZYRO0F04950g weakly similar to uniprot|P53108 Saccharomyces cerevisiae YGL161C YIP5 Protein that interacts with Rab GTPases computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport ZYRO0F04994g similar to uniprot|P39988 Saccharomyces cerevisiae YEL029C ZYRO0F05016g similar to uniprot|P47111 Saccharomyces cerevisiae YJR044C VPS55 Vacuolar Protein Sorting YJR044c ZYRO0F05038g highly similar to uniprot|P12398 Saccharomyces cerevisiae YJR045C ZYRO0F05060g similar to uniprot|P47112 Saccharomyces cerevisiae YJR046W TAH11 (DNA replication) ZYRO0F05082g highly similar to uniprot|P39986 Saccharomyces cerevisiae YEL031W SPF1 Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa P-type ATPase ZYRO0F05104g similar to uniprot|P24279 Saccharomyces cerevisiae YEL032W MCM3 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex ZYRO0F05148g highly similar to uniprot|P19211 Saccharomyces cerevisiae ANB1 Translation initiation factor eIF-5A, and to YEL034W uniprot|P23301 Saccharomyces cerevisiae YEL034W HYP2 Translation initiation factor eIF-5A ZYRO0F05170g similar to uniprot|P32629 Saccharomyces cerevisiae YEL036C ANP1 Mannan 8 Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol subunit of mannosyltransferase complex ZYRO0F05192g similar to uniprot|P32628 Saccharomyces cerevisiae YEL037C RAD23 ZYRO0F05214g similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W and similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C ZYRO0F05236g similar to uniprot|P32626 Saccharomyces cerevisiae YEL038W UTR4 Protein of unknown function found in both the cytoplasm and nucleus ZYRO0F05258g highly similar to uniprot|P00044 Saccharomyces cerevisiae CYC1 Cytochrome c isoform 1 and to YEL039C uniprot|P00045 Saccharomyces cerevisiae CYC7 Cytochrome c isoform 2 ZYRO0F05280g similar to uniprot|P32623 Saccharomyces cerevisiae YEL040W UTR2 Putative glycosidase glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck has a role in cell wall maintenance ZYRO0F05302g similar to uniprot|P21373 Saccharomyces cerevisiae YJR049C UTR1 NAD kinase active as a hexamer enhances the activity of ferric reductase (Fre1p) ZYRO0F05324g highly similar to uniprot|P32621 Saccharomyces cerevisiae YEL042W GDA1 Guanosine diphosphatase located in the Golgi involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate ZYRO0F05346g similar to uniprot|P21374 Saccharomyces cerevisiae YJR050W ISY1 Component of the spliceosome complex involved in pre-mRNA splicing auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing isy1 syf2 double mutation activates the spindle checkpoint causing cell cycle arrest ZYRO0F05368g no similarity ZYRO0F05412g some similarities with uniprot|P38723 Saccharomyces cerevisiae YHL048W COS8 ZYRO0F05434g no similarity ZYRO0F05456g weakly similar to uniprot|P32618 Saccharomyces cerevisiae YEL043W member vGLC.2184 ZYRO0F05478g similar to uniprot|P32617 Saccharomyces cerevisiae YEL044W IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions ZYRO0F05500g highly similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis ZYRO0F05522g similar to uniprot|P32614 Saccharomyces cerevisiae YEL047C Fumurate ReDuctase Soluble ZYRO0F05544g similar to uniprot|P32613 Saccharomyces cerevisiae YEL048C Hypothetical ORF ZYRO0F05566g weakly similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C ZYRO0F05588g weakly similar to uniprot|P48568 Saccharomyces cerevisiae YDL186W Hypothetical ORF ZYRO0F05610g highly similar to uniprot|P23595 Saccharomyces cerevisiae YDL188C PPH22 Catalytic subunit of protein phosphatase 2A functionally redundant with Pph21p methylated at C terminus forms alternate complexes with several regulatory subunits involved in signal transduction and regulation of mitosis ZYRO0F05632g conserved hypothetical protein ZYRO0F05654g highly similar to uniprot|Q12434 Saccharomyces cerevisiae YDL135C RDI1 Rho GDP dissociation inhibitor ZYRO0F05676g some similarities with uniprot|Q870H2 Saccharomyces cerevisiae YDL189W RBS1 Protein of unknown function identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization proposed to bind single-stranded nucleic acids via its R3H domain ZYRO0F05698g similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex ZYRO0F05720g highly similar to uniprot|P39741 Saccharomyces cerevisiae YDL191W RPL35A and YDL136W RPL35B, proteins component of the large (60S) ribosomal subunit ZYRO0F05742g highly similar to uniprot|P11076 Saccharomyces cerevisiae YDL192W ARF1 ADP-ribosylation factor GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi functionally interchangeable with Arf2p ZYRO0F05764g similar to uniprot|Q12063 Saccharomyces cerevisiae YDL193W NUS1 ZYRO0F05786g similar to uniprot|P10870 Saccharomyces cerevisiae YDL194W SNF3 glucose sensor ZYRO0F05808g similar to uniprot|P38968 Saccharomyces cerevisiae YDL195W SEC31 involved in protein transport from endoplasmic reticulum to Golgi Component (p150) of COPII coat of secretory pathway vesicles ZYRO0F05830g similar to uniprot|Q05809 Saccharomyces cerevisiae YLR218C Hypothetical ORF ZYRO0F05852g weakly similar to uniprot|Q12334 Saccharomyces cerevisiae YDL139C SCM3 Suppressor of chromosome missegregation ZYRO0F05874g highly similar to uniprot|P53691 Saccharomyces cerevisiae YLR216C CPR6 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity ZYRO0F05896g no similarity ZYRO0F05918g highly similar to uniprot|P04050 Saccharomyces cerevisiae YDL140C ZYRO0F05940g similar to uniprot|P48445 Saccharomyces cerevisiae YDL141W BPL1 Biotin:apoprotein ligase ZYRO0F05962g similar to uniprot|Q07560 Saccharomyces cerevisiae YDL142C CRD1 Cardiolipin synthase produces cardiolipin which is an important constituent of mitochondrial membranes required for normal mitochondrial membrane potential and function ZYRO0F05984g highly similar to uniprot|P39078 Saccharomyces cerevisiae YDL143W CCT4 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo ZYRO0F06006g similar to uniprot|Q05791 Saccharomyces cerevisiae YLR215C CDC123 ZYRO0F06028g similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF ZYRO0F06050g similar to uniprot|Q05790 Saccharomyces cerevisiae YLR213C ZYRO0F06072g similar to uniprot|Q02933 Saccharomyces cerevisiae YPL123C RNY1 RNAse member of the T(2) family of endoribonucleases ZYRO0F06094g similar to uniprot|Q08579 Saccharomyces cerevisiae YOR192C Hypothetical ORF ZYRO0F06116g conserved hypothetical protein ZYRO0F06138g some similarities with uniprot|P29461 Saccharomyces cerevisiae YOR208W PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the nucleus ZYRO0F06160g highly similar to uniprot|Q02932 Saccharomyces cerevisiae YPL125W KAP120 Karyopherin with a role in the assembly or export of 60S ribosomal subunits ZYRO0F06182g highly similar to uniprot|P39683 Saccharomyces cerevisiae YOR209C NPT1 Nicotinate phosphoribosyltransferase ZYRO0F06204g similar to Q02931 YPL126W uniprot|Q02931 Saccharomyces cerevisiae NAN1 U3 snoRNP protein component of the small (ribosomal) subunit (SSU) processosome containing U3 ZYRO0F06226g highly similar to uniprot|P22139 Saccharomyces cerevisiae YOR210W RPB10 RNA polymerase subunit ABC10-beta common to RNA polymerases I II and III ZYRO0F06248g similar to uniprot|P32266 YOR211C Saccharomyces cerevisiae MGM1 Mitochondrial GTPase related to dynamin present in a complex containing Ugo1p and Fzo1p ZYRO0F06270g similar to uniprot|P53551 Saccharomyces cerevisiae YPL127C HHO1 Histone H1 a linker histone required for nucleosome packaging at restricted sites suppresses DNA repair involving homologous recombination not required for telomeric silencing basal transcriptional repression or efficient sporulation ZYRO0F06292g similar to uniprot|Q02457 YPL128C Saccharomyces cerevisiae TBF1 TTAGGG repeat binding factor ZYRO0F06314g similar to uniprot|P18851 YOR212W Saccharomyces cerevisiae STE4 G protein beta subunit ZYRO0F06336g similar to uniprot|Q99314 Saccharomyces cerevisiae YOR213C SAS5 Subunit of the SAS complex (Sas2p Sas4p Sas5p) which acetylates free histones and nucleosomes and regulates transcriptional silencing stimulates Sas2p HAT activity ZYRO0F06358g highly similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W TAF14 Subunit (30 kDa) of TFIID TFIIF and SWI/SNF complexes involved in RNA polymerase II transcription initiation and in chromatin modification contains a YEATS domain ZYRO0F06380g no similarity ZYRO0F06402g similar to Q12032 YOR215C uniprot|Q12032 Saccharomyces cerevisiae Hypothetical ORF ZYRO0F06424g similar to Q12234 YOR216C uniprot|Q12234 Saccharomyces cerevisiae RUD3 Golgi matrix protein that is involved in the structural organization of the cis-Golgi ZYRO0F06446g similar to uniprot|P38630 Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon ZYRO0F06468g similar to uniprot|P33894 Saccharomyces cerevisiae YOR219C STE13 Dipeptidyl aminopeptidase Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences required for maturation of alpha factor transcription is induced by a-factor ZYRO0F06490g highly similar to uniprot|P26321 Saccharomyces cerevisiae YPL131W RPL5 component of the large (60S) ribosomal subunit ZYRO0F06512g similar to gnl|GLV|CAGL0J04158g Candida glabrata CAGL0J04158g and weakly similar to YOR220W uniprot|Q12044 Saccharomyces cerevisiae YOR220W Hypothetical ORF ZYRO0F06534g similar to uniprot|P19516 YPL132W Saccharomyces cerevisiae COX11 Mitochondrial membrane protein required for assembly of active cytochrome c oxidase ZYRO0F06556g similar to uniprot|P19541 Saccharomyces cerevisiae YPL133C RDS2 Regulator of drug sensitivity Transcriptional regulator ZYRO0F06578g similar to uniprot|Q12283 Saccharomyces cerevisiae YOR221C MCT1 Predicted malonyl-CoA:ACP transferase putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling ZYRO0F06600g similar to uniprot|Q03028 Saccharomyces cerevisiae YPL134C ODC1 Mitochondrial inner membrane transporter exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism ZYRO0F06622g similar to uniprot|Q12015 Saccharomyces cerevisiae YOR223W Hypothetical ORF ZYRO0F06644g highly similar to gnl|GLV|CAGL0J04070g Candida glabrata CAGL0J04070g and similar to YOR224C uniprot|P20436 Saccharomyces cerevisiae RPB8 RNA polymerase subunit ABC14.5 common to RNA polymerases I II and III ZYRO0F06688g similar to uniprot|Q03020 Saccharomyces cerevisiae YPL135W ISU1 Conserved protein of the mitochondrial matrix ZYRO0F06710g similar to uniprot|Q03016 Saccharomyces cerevisiae YPL137C Hypothetical ORF ZYRO0F06732g similar to Q12106 YOR228C uniprot|Q12106 Saccharomyces cerevisiae Hypothetical ORF ZYRO0F06754g similar to uniprot|Q03012 Saccharomyces cerevisiae YPL138C ZYRO0F06776g similar to uniprot|Q12206 Saccharomyces cerevisiae YOR229W WTM2 WD repeat containing transcriptional modulator 2 Transcriptional modulator ZYRO0F06798g similar to uniprot|P32491 Saccharomyces cerevisiae YPL140C MKK2 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity upon activation by Bck1p phosphorylates downstream target Slt2p functionally redundant with Mkk1p ZYRO0F06820g some similarities with uniprot|P38523 YOR232W Saccharomyces cerevisiae MGE1 Protein of the mitochondrial matrix involved in protein import into mitochondria ZYRO0F06842g similar to Saccharomyces cerevisiae YPL141C and to YOR233W uniprot|Q01919 Saccharomyces cerevisiae YOR233W KIN4 Nonessential protein kinase with unknown cellular role ZYRO0F06864g highly similar to uniprot|P05744 Saccharomyces cerevisiae YPL143W, RPL33A Ribosomal Protein of the Large subunit ZYRO0F06908g similar to uniprot|Q6Q5F7 Saccharomyces cerevisiae YPL144W Hypothetical ORF ZYRO0F06930g similar to uniprot|P07807 Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase part of the dTTP biosynthetic pathway involved in folate metabolism possibly required for mitochondrial function ZYRO0F06952g highly similar to gnl|GLV|KLLA0D07480g Kluyveromyces lactis KLLA0D07480g and similar to YPL145C uniprot|P35844 Saccharomyces cerevisiae YPL145C KES1 Member of the oxysterol binding protein family which includes seven yeast homologs involved in negative regulation of Sec14p-dependent Golgi complex secretory functions peripheral membrane protein that localizes to the Golgi complex ZYRO0F06974g similar to uniprot|Q12080 Saccharomyces cerevisiae YPL146C NOP53 Nucleolar protein involved in biogenesis of the 60S subunit of the ribosome interacts with rRNA processing factors Cbf5p and Nop2p null mutant is viable but growth is severely impaired ZYRO0F06996g similar to uniprot|Q08634 Saccharomyces cerevisiae YOR238W Hypothetical ORF ZYRO0F07018g similar to uniprot|P41909 Saccharomyces cerevisiae YPL147W PXA1 Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-binding cassette transporter necessary for transport of long-chain fatty acids into peroxisomes ABC family long-chain fatty acid transporter ZYRO0F07040g conserved hypothetical protein ZYRO0F07062g conserved hypothetical protein ZYRO0F07084g similar to gnl|GLV|CAGL0M02365g Candida glabrata CAGL0M02365g and weakly similar to YPL148C uniprot|Q12036 Saccharomyces cerevisiae YPL148C PPT2 Phosphopantetheine:protein transferase (PPTase) activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation ZYRO0F07150g similar to uniprot|Q12380 Saccharomyces cerevisiae YPL149W ATG5 Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation ZYRO0F07172g conserved hypothetical protein ZYRO0F07194g similar to uniprot|Q12152 Saccharomyces cerevisiae YPL150W Hypothetical ORF ZYRO0F07216g similar to uniprot|Q08645 Saccharomyces cerevisiae YOR241W MET7 Folylpolyglutamate synthetase catalyzes extension of the glutamate chains of the folate coenzymes required for methionine synthesis and for maintenance of mitochondrial DNA present in both the cytoplasm and mitochondria ZYRO0F07238g similar to uniprot|Q96US5 Saccharomyces cerevisiae YOR242C SSP2 Sporulation SPecific involved in sporulation ZYRO0F07260g highly similar to uniprot|Q08647 Saccharomyces cerevisiae YOR243C PUS7 pseudouridylates U2 snRNA at position 35 ZYRO0F07282g similar to uniprot|Q12417 Saccharomyces cerevisiae YPL151C PRP46 Splicing factor that is found in the Cef1p subcomplex of the spliceosome ZYRO0F07304g highly similar to uniprot|Q08649 Saccharomyces cerevisiae YOR244W ESA1 Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail required for cell cycle progression ZYRO0F07326g highly similar to uniprot|Q12461 Saccharomyces cerevisiae YPL152W ZYRO0F07348g similar to uniprot|Q08650 Saccharomyces cerevisiae YOR245C DGA1 Diacylglycerol acyltransferase catalyzes the terminal step of triacylglycerol (TAG) formation acylates diacylglycerol using acyl-CoA as an acyl donor localized to lipid particles ZYRO0F07370g similar to uniprot|P22216 Saccharomyces cerevisiae YPL153C RAD53 Protein kinase required for cell-cycle arrest in response to DNA damage activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p ZYRO0F07392g highly similar to uniprot|P07267 Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (proteinase A) required for the posttranslational precursor maturation of vacuolar proteinases synthesized as a zymogen self-activates ZYRO0F07414g similar to uniprot|P28743 Saccharomyces cerevisiae YPL155C KIP2 Kinesin-related motor protein involved in mitotic spindle positioning ZYRO0F07436g similar to uniprot|Q12052 Saccharomyces cerevisiae YPL157W TGS1 TrimethylGuanosine Synthase ZYRO0F07458g some similarities with uniprot|Q99299 Saccharomyces cerevisiae YPL158C Hypothetical ORF ZYRO0F07480g similar to uniprot|Q99373 Saccharomyces cerevisiae YPL159C PET20 Protein required for respiratory growth and stability of the mitochondrial genome ZYRO0F07502g conserved hypothetical protein ZYRO0F07524g highly similar to uniprot|P26637 Saccharomyces cerevisiae YPL160W CDC60 Cytosolic leucyl tRNA synthetase ligates leucine to the appropriate tRNA ZYRO0F07546g similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases ZYRO0F07568g similar to uniprot|P39011 Saccharomyces cerevisiae YPL161C BEM4 Protein involved in establishment of cell polarity and bud emergence interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p ZYRO0F07590g similar to uniprot|Q12042 Saccharomyces cerevisiae YPL162C Hypothetical ORF ZYRO0F07612g weakly similar to uniprot|Q12254 Saccharomyces cerevisiae YPL163C ZYRO0F07634g similar to uniprot|Q12083 Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair forms a complex with Mlh1p to promote meiotic crossing-over mammalian homolog is implicated mammalian microsatellite instability ZYRO0F07656g similar to uniprot|Q08683 Saccharomyces cerevisiae YOR249C APC5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition ZYRO0F07678g similar to uniprot|Q08685 Saccharomyces cerevisiae YOR250C CLP1 cleavage/polyadenylation factor IA subunit interacts with Pcf11p in the 2-hybrid system cleavage/polyadenylation factor IA subunit ZYRO0F07700g similar to uniprot|Q08686 Saccharomyces cerevisiae YOR251C catalyzes transfer of the sulfane atom of thiosulfate to cyanide to form sulfite and thiocyanate ZYRO0F07722g similar to uniprot|Q12529 Saccharomyces cerevisiae YPL165C SET6 ZYRO0F07744g similar to gnl|GLV|KLLA0C09933g Kluyveromyces lactis KLLA0C09933g and weakly similar to uniprot|Q12092 Saccharomyces cerevisiae YPL166W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0F07766g similar to uniprot|P14284 Saccharomyces cerevisiae YPL167C REV3 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage ZYRO0F07788g similar to uniprot|Q08687 Saccharomyces cerevisiae YOR252W RBF17 Hypothetical ORF ZYRO0F07810g weakly similar to uniprot|Q12467 Saccharomyces cerevisiae YPL168W Hypothetical ORF ZYRO0F07832g similar to uniprot|P53118 Saccharomyces cerevisiae YGL144C ROG1 Protein with putative serine active lipase domain ZYRO0F07854g similar to uniprot|P33891 Saccharomyces cerevisiae YGL145W TIP20 transport protein that interacts with Sec20p required for protein transport from the endoplasmic reticulum to the golgi apparatus ZYRO0F07876g similar to uniprot|Q12513 Saccharomyces cerevisiae YDL110C Hypothetical ORF ZYRO0F07898g weakly similar to uniprot|P53117 Saccharomyces cerevisiae YGL146C Hypothetical ORF ZYRO0F07920g highly similar to uniprot|Q12277 Saccharomyces cerevisiae YDL111C RRP42 Ribosomal RNA Processing Component of the exosome 3->5 exoribonuclease complex with Rrp4p Rrp41p Rrp43p and Dis3p (Rrp44p). ZYRO0F07942g similar to uniprot|Q7LGS3 Saccharomyces cerevisiae YDL112W TRM3 2'-O-ribose methyltransferase catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs ZYRO0F07964g similar to uniprot|Q07528 Saccharomyces cerevisiae YDL113C ATG20 Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway binds phosphatidylinositol-3-phosphate involved in localization of membranes to the preautophagosome potential Cdc28p substrate ZYRO0F07986g similar to uniprot|Q07530 Saccharomyces cerevisiae YDL114W Hypothetical ORF ZYRO0F08008g similar to uniprot|A2TBP4 Saccharomyces cerevisiae YDL115C IWR1 Protein of unknown function deletion causes hypersensitivity to the K1 killer toxin ZYRO0F08030g highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins ZYRO0F08052g similar to uniprot|Q2XN15 Saccharomyces cerevisiae YPL030W Hypothetical ORF ZYRO0F08074g highly similar to uniprot|P17157 Saccharomyces cerevisiae YPL031C PHO85 Cyclin-dependent kinase with ten cyclin partners involved in environmental stress response in phosphate-rich conditions Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5 ZYRO0F08096g similar to uniprot|Q03787 Saccharomyces cerevisiae YDR249C Hypothetical ORF ZYRO0F08118g similar to uniprot|Q03088 Saccharomyces cerevisiae YPL032C SVL3 Protein of unknown function mutant phenotype suggests a potential role in vacuolar function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck ZYRO0F08140g similar to uniprot|Q02642 Saccharomyces cerevisiae YPL037C EGD1 Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting associated with cytoplasmic ribosomes enhances DNA binding of the Gal4p activator homolog of human BTF3b ZYRO0F08162g similar to uniprot|Q12041 Saccharomyces cerevisiae YDR253C MET32 Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes ZYRO0F08184g some similarities with uniprot|Q03080 Saccharomyces cerevisiae YPL039W Hypothetical ORF ZYRO0F08206g similar to uniprot|P48526 Saccharomyces cerevisiae YPL040C ISM1 Mitochondrial isoleucyl-tRNA synthetase null mutant is deficient in respiratory growth ZYRO0F08228g similar to uniprot|P38227 Saccharomyces cerevisiae YBR043C QDR3 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR) ZYRO0F08250g some similarities with uniprot|Q6LE92 Saccharomyces cerevisiae YPL041C Hypothetical ORF ZYRO0F08272g similar to uniprot|P39073 Saccharomyces cerevisiae YPL042C SSN3 Component of RNA polymerase II holoenzyme involved in RNA pol II carboxy-terminal domain phosphorylation ZYRO0F08294g similar to uniprot|P37838 Saccharomyces cerevisiae YPL043W NOP4 Nucleolar protein essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis contains four RNA recognition motifs (RRMs) ZYRO0F08316g similar to uniprot|P38907 Saccharomyces cerevisiae YDR254W CHL4 Outer kinetochore protein required for chromosome stability interacts with kinetochore proteins Ctf19p Ctf3p and Iml3p exhibits a two-hybrid interaction with Mif2p association with CEN DNA requires Ctf19p ZYRO0F08338g similar to uniprot|Q03308 Saccharomyces cerevisiae YPL045W VPS16 Vacuolar sorting protein ZYRO0F08360g similar to uniprot|O13292 Saccharomyces cerevisiae YPL046C ELC1 Elongin C forms heterodimer with Ela1p that participates in transcription elongation expression dramatically upregulated during sporulation widely conserved among eukaryotes ZYRO0F08382g similar to uniprot|Q12508 Saccharomyces cerevisiae YDR255C RMD5 Cytosolic protein required for sporulation also required for the ubiquitination of the gluconeogenetic enzyme fructose-1 6-bisphosphatase which is degraded rapidly after the switch from gluconeogenesis to glycolysis ZYRO0F08404g highly similar to uniprot|Q03067 Saccharomyces cerevisiae YPL047W SGF11 11kDa subunit of the SAGA histone acetyltransferase complex involved in regulation of transcription of a subset of SAGA-regulated genes ZYRO0F08426g highly similar to uniprot|P15202 Saccharomyces cerevisiae YDR256C CTA1 Catalase A breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation ZYRO0F08448g similar to uniprot|P29547 Saccharomyces cerevisiae YPL048W CAM1 Translational cofactor elongation factor-1 gamma participates in the regulation of GTP-binding protein EF-1 alpha may play a redundant role in the regulation of protein synthesis or another GTP-dependent process ZYRO0F08470g some similarities with uniprot|Q03063 Saccharomyces cerevisiae YPL049C DIG1 Regulatory protein of unknown function constitutively-expressed involved in the regulation of mating-specific genes and the invasive growth pathway required for MAP-kinase imposed repression inhibits pheromone-responsive transcription ZYRO0F08492g highly similar to uniprot|P39107 Saccharomyces cerevisiae YPL050C MNN9 Subunit of Golgi mannosyltransferase complex also containing Anp1p Mnn10p Mnn11p and Hoc1p that mediates elongation of the polysaccharide mannan backbone forms a separate complex with Van1p that is also involved in backbone elongation ZYRO0F08514g similar to uniprot|P11491 Saccharomyces cerevisiae YDR481C PHO8 Repressible alkaline phosphatase a glycoprotein localized to the vacuole regulated by levels of inorganic phosphate and by a system consisting of Pho4p Pho9p Pho80p Pho81p and Pho85p dephosphorylates phosphotyrosyl peptides ZYRO0F08536g highly similar to uniprot|Q02804 Saccharomyces cerevisiae YPL051W ARL3 GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor ZYRO0F08558g similar to uniprot|Q03375 Saccharomyces cerevisiae YDR482C ZYRO0F08580g similar to uniprot|Q02803 Saccharomyces cerevisiae YPL052W OAZ1 Regulator of ornithine decarboxylase (Spe1p) antizyme that binds to Spe1p to regulate ubiquitin-independent degradation ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated ZYRO0F08602g similar to uniprot|P27809 Saccharomyces cerevisiae YDR483W KRE2 Alpha1 2-mannosyltransferase of the Golgi involved in protein mannosylation ZYRO0F08624g similar to uniprot|P33313 Saccharomyces cerevisiae YBR155W CNS1 cyclophilin seven suppressor component of Hsp90p chaperone machinery ZYRO0F08646g some similarities with uniprot|P38283 Saccharomyces cerevisiae YBR156C SLI15 Mitotic spindle protein involved in chromosome segregation. ZYRO0F08668g conserved hypothetical protein ZYRO0F08690g some similarities with uniprot|Q06701 Saccharomyces cerevisiae YPL054W LEE1 Protein of unknown function ZYRO0F08712g similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome STability Chromosome STability ZYRO0F08734g some similarities with uniprot|Q6Q5I8 Saccharomyces cerevisiae YPL055C LGE1 Protein of unknown function null mutant forms abnormally large cells ZYRO0F08756g similar to uniprot|P38286 Saccharomyces cerevisiae YBR159W microsomal beta-keto-reductase ZYRO0F08778g highly similar to uniprot|P00546 Saccharomyces cerevisiae YBR160W CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK) alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates ZYRO0F08800g similar to uniprot|P33300 Saccharomyces cerevisiae YPL057C SUR1 Probable catalytic subunit of a mannosylinositol phosphorylceramide ZYRO0F08844g weakly similar to uniprot|P38288 Saccharomyces cerevisiae YBR162C TOS1 Target of SBF ZYRO0F08866g highly similar to uniprot|Q02785 Saccharomyces cerevisiae YPL058C PDR12 Plasma membrane weak-acid-inducible ATP-binding cassette (ABC) transporter required for weak organic acid resistance strongly induced by sorbate and benzoate regulated by War1p mutants exhibit sorbate hypersensitivity ZYRO0F08888g highly similar to uniprot|Q02785 Saccharomyces cerevisiae YPL058C PDR12 Plasma membrane weak-acid-inducible ATP-binding cassette (ABC) transporter required for weak organic acid resistance strongly induced by sorbate and benzoate regulated by War1p mutants exhibit sorbate hypersensitivity ZYRO0F08910g similar to uniprot|P38289 Saccharomyces cerevisiae YBR163W ZYRO0F08932g similar to uniprot|Q02784 Saccharomyces cerevisiae YPL059W GRX5 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers monothiol glutaredoxin subfamily member along with Grx3p and Grx4p ZYRO0F08976g highly similar to uniprot|P32528 Saccharomyces cerevisiae YBR208C DUR1 2 Urea amidolyase contains both urea carboxylase and allophanate hydrolase activities degrades urea to CO2 and NH3 expression sensitive to nitrogen catabolite repression and induced by allophanate an intermediate in allantoin degradation ZYRO0F08998g similar to uniprot|P38310 Saccharomyces cerevisiae YBR207W FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron forms complex with Fet5p expression is regulated by iron proposed to play indirect role in endocytosis ZYRO0F09020g similar to uniprot|Q6B1B1 Saccharomyces cerevisiae YPL060W LPE10 Mitochondrial inner membrane magnesium transporter involved in maintenance of magnesium concentrations inside mitochondria indirectly affects splicing of group II introns functionally and structurally related to Mrs2p ZYRO0F09042g highly similar to uniprot|P38130 Saccharomyces cerevisiae YBR205W KTR3 Putative alpha-1 2-mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family ZYRO0F09064g similar to uniprot|P38139 Saccharomyces cerevisiae YBR204C Hypothetical ORF ZYRO0F09086g weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W ZYRO0F09108g some similarities with uniprot|P38308 Saccharomyces cerevisiae YBR203W COS111 Protein required for wild-type resistance to the antifungal drug ciclopirox olamine not related to the COS family of subtelomerically-encoded proteins ZYRO0F09130g similar to uniprot|Q02776 Saccharomyces cerevisiae YPL063W TIM50 Protein of the inner mitochondrial membrane required for import of mitochondrial matrix proteins ZYRO0F09152g weakly similar to uniprot|Q02770 Saccharomyces cerevisiae YPL064C ZYRO0F09174g weakly similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C ZYRO0F09196g similar to uniprot|Q02767 Saccharomyces cerevisiae YPL065W VPS28 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole ZYRO0F09218g similar to uniprot|Q12194 Saccharomyces cerevisiae YPL066W Hypothetical ORF ZYRO0F09240g highly similar to uniprot|P38132 Saccharomyces cerevisiae YBR202W CDC47 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase ZYRO0F09262g conserved hypothetical protein ZYRO0F09284g similar to uniprot|P39946 Saccharomyces cerevisiae YOR269W PAC1 Protein involved in nuclear migration part of the dynein/dynactin pathway targets dynein to microtubule tips which is necessary for sliding of microtubules along bud cortex synthetic lethal with bni1 homolog of human LIS1 ZYRO0F09306g similar to uniprot|P32563 Saccharomyces cerevisiae YOR270C VPH1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Vph1p and Stv1p) Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes ZYRO0F09328g similar to uniprot|P07277 Saccharomyces cerevisiae YMR208W ERG12 Mevalonate kinase acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate ZYRO0F09350g similar to uniprot|Q12029 Saccharomyces cerevisiae YOR271C Hypothetical ORF ZYRO0F09372g highly similar to uniprot|Q12024 Saccharomyces cerevisiae YOR272W YTM1 microtubule-associated protein ZYRO0F09394g similar to uniprot|Q03648 Saccharomyces cerevisiae YMR209C Hypothetical ORF ZYRO0F09438g similar to uniprot|Q03652 Saccharomyces cerevisiae YMR211W ZYRO0F09460g similar to uniprot|P07884 Saccharomyces cerevisiae YOR274W MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs gene is nuclear and encodes two isozymic forms ZYRO0F09482g similar to uniprot|Q12033 Saccharomyces cerevisiae YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH member of the PalA/AIP1/Alix family interacts with the ESCRT-III subunits Snf7p suggesting a relationship between the response to pH and multivesicular body formation ZYRO0F09504g similar to uniprot|Q03653 Saccharomyces cerevisiae YMR212C EFR3 Non-essential protein of unknown function exhibits synthetic lethal genetic interactions with PHO85 green fluorescent protein (GFP)-fusion protein localizes to the cell periphery ZYRO0F09526g similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor associated with Prp19p and the spliceosome contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association evolutionarily conserved and homologous to S. pombe Cdc5p ZYRO0F09548g similar to uniprot|P07285 YDR354W Saccharomyces cerevisiae TRP4 anthranilate phosphoribosyl transferase ZYRO0F09570g similar to uniprot|Q756L3 Ashbya gossypii AER241W AER241Wp and weakly similar to uniprot|P32380 Saccharomyces cerevisiae YDR356W SPC110 Inner plaque spindle pole body (SPB) component ZYRO0F09592g similar to uniprot|Q06333 YDR357C Saccharomyces cerevisiae Protein of unknown function ZYRO0F09614g similar to uniprot|P38817 YHR108W Saccharomyces cerevisiae GGA2 Golgi-localized protein with homology to gamma-adaptin ZYRO0F09636g similar to uniprot|Q06337 YDR359C Saccharomyces cerevisiae VID21 Component of the NuA4 histone acetyltransferase complex ZYRO0F09658g similar to uniprot|Q06338 YDR361C Saccharomyces cerevisiae BCP1 Essential protein involved in nuclear export of Mss4p ZYRO0F09680g weakly similar to uniprot|P38818 YHR109W Saccharomyces cerevisiae CTM1 Cytochrome c lysine methyltransferase ZYRO0F09702g similar to uniprot|P38819 Saccharomyces cerevisiae YHR110W ZYRO0F09724g similar to uniprot|P38820 YHR111W Saccharomyces cerevisiae UBA4 Protein that activates Urm1p before its conjugation to proteins (urmylation) ZYRO0F09746g similar to uniprot|Q06339 YDR362C Saccharomyces cerevisiae TFC6 one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) ZYRO0F09768g highly similar to uniprot|P38716 Saccharomyces cerevisiae YHR112C Hypothetical ORF ZYRO0F09790g highly similar to uniprot|P38821 YHR113W Saccharomyces cerevisiae Hypothetical ORF ZYRO0F09812g weakly similar to uniprot|Q06340 YDR363W Saccharomyces cerevisiae ESC2 Protein involved in mating-type locus silencing interacts with Sir2p ZYRO0F09856g highly similar to uniprot|P04051 Saccharomyces cerevisiae YOR116C ZYRO0F09878g weakly similar to uniprot|O94742 Saccharomyces cerevisiae YDR363W-A SEM1 ZYRO0F09900g highly similar to uniprot|P33297 Saccharomyces cerevisiae YOR117W RPT5 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates recruited to the GAL1-10 promoter region upon induction of transcription ZYRO0F09922g similar to uniprot|P40968 Saccharomyces cerevisiae YDR364C CDC40 Pre-mRNA splicing factor important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression required for DNA synthesis during mitosis and meiosis has WD repeats ZYRO0F09944g similar to uniprot|Q06344 YDR365C Saccharomyces cerevisiae ESF1 Nucleolar protein involved in pre-rRNA processing ZYRO0F09966g similar to uniprot|Q12108 YOR118W Saccharomyces cerevisiae Hypothetical ORF ZYRO0F09988g similar to uniprot|Q12196 YOR119C Saccharomyces cerevisiae RIO1 Essential protein that plays a role in cell cycle progression ZYRO0F10010g similar to uniprot|Q06999 Saccharomyces cerevisiae YDR367W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0F10032g uniprot|Q9HGX9 Zygosaccharomyces rouxii ZGCY2 Glycerol dehydrogenase ZYRO0F10054g weakly similar to uniprot|P33301 Saccharomyces cerevisiae YDR369C XRS2 classified as an early recombination function required for DNA repair but dispensable for mitotic recombination (xrs2 is hyper-Rec during vegatative growth) required for double strand breaks meiotic recombination and spore viability DNA repair protein ZYRO0F10076g similar to gnl|GLV|KLLA0E02222g Kluyveromyces lactis KLLA0E02222g and some similarites with YNL026W uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM complex) of the mitochondrial outer membrane the authentic non-tagged protein was localized to the mitochondria ZYRO0F10098g similar to uniprot|Q06349 Saccharomyces cerevisiae YDR370C Hypothetical ORF ZYRO0F10120g conserved hypothetical protein ZYRO0F10142g highly similar to uniprot|P07274 Saccharomyces cerevisiae YOR122C PFY1 Profilin actin- and phosphatidylinositol 4 5-bisphosphate-binding protein plays a role in cytoskeleton organization required for normal timing of actin polymerization in response to thermal stress localizes to plasma membrane and cytosol ZYRO0F10164g similar to uniprot|P38439 Saccharomyces cerevisiae YOR123C LEO1 Component of the Paf1 complex which associates with RNA polymerase II and is involved in histone methylation ZYRO0F10186g similar to uniprot|Q06350 Saccharomyces cerevisiae YDR371W CTS2 Sporulation-specific chitinase ZYRO0F10208g highly similar to uniprot|Q06385 Saccharomyces cerevisiae YDR372C VPS74 ZYRO0F10230g similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. ZYRO0F10252g weakly similar to YYIL015W uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. ZYRO0F10274g similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. ZYRO0F10296g weakly similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. ZYRO0F10318g similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. ZYRO0F10340g similar to uniprot|Q7LGV7 Saccharomyces cerevisiae YLR127C ZYRO0F10362g similar to uniprot|Q12395 Saccharomyces cerevisiae YLR128W DCN1 Hypothetical ORF ZYRO0F10384g some similarities with uniprot|Q03761 Saccharomyces cerevisiae YDR145W ZYRO0F10406g similar to uniprot|Q12220 Saccharomyces cerevisiae YLR129W DIP2 Nucleolar protein specifically associated with the U3 snoRNA part of the large ribonucleoprotein complex known as the small subunit (SSU) processome required for 18S rRNA biogenesis part of the active pre- rRNA processing complex ZYRO0F10428g similar to uniprot|P21192 Saccharomyces cerevisiae YLR131C ACE2 Transcription factor that activates expression of early G1-specific genes localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters localization is regulated by phosphorylation potential Cdc28p substrate ZYRO0F10450g weakly similar to uniprot|Q12208 Saccharomyces cerevisiae YLR132C Protein required for cell viability ZYRO0F10472g similar to uniprot|P20485 Saccharomyces cerevisiae YLR133W CKI1 choline kinase ZYRO0F10494g similar to uniprot|P19262 Saccharomyces cerevisiae YDR148C KGD2 Dihydrolipoyl transsuccinylase a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha- ketoglutarate to succinyl-CoA ZYRO0F10516g some similarities with uniprot|Q12098 Saccharomyces cerevisiae YLR135W SLX4 Subunit of a complex with Slx1p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p ZYRO0F10538g weakly similar to uniprot|Q00402 Saccharomyces cerevisiae YDR150W NUM1 Protein required for nuclear migration localizes to the mother cell cortex and the bud tip may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex ZYRO0F10560g similar to uniprot|P47976 Saccharomyces cerevisiae YDR151C CTH1 Member of the CCCH zinc finger family and uniprot|P47977 Saccharomyces cerevisiae YLR136C TIS11 mRNA-binding protein expressed during iron starvation ZYRO0F10582g conserved hypothetical protein ZYRO0F10604g similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase responsible for arginine degradation expression responds to both induction by arginine and nitrogen catabolite repression disruption enhances freeze tolerance ZYRO0F10648g weakly similar to uniprot|Q6B2A9 Saccharomyces cerevisiae YPL112C PEX25 Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance recruits GTPase Rho1p to peroxisomes induced by oleate interacts with homologous protein Pex27p ZYRO0F10670g similar to uniprot|Q02961 Saccharomyces cerevisiae YPL113C Putative dehydrogenase ZYRO0F10692g similar to uniprot|P32773 Saccharomyces cerevisiae YOR194C TOA1 Transcription factor IIA large chain ZYRO0F10714g weakly similar to uniprot|Q08581 Saccharomyces cerevisiae YOR195W SLK19 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis component of the FEAR regulatory network which promotes Cdc14p release from the nucleolus during anaphase potential Cdc28p substrate ZYRO0F10736g similar to uniprot|P32873 Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization targets the essential Rho-GTPase Cdc42p which controls establishment and maintenance of cell polarity including bud-site assembly ZYRO0F10758g highly similar to uniprot|Q74ZH6 Ashbya gossypii AGR231C AGR231Cp and similar to YOR196C uniprot|P32875 Saccharomyces cerevisiae ZYRO0F10780g similar to uniprot|Q02959 Saccharomyces cerevisiae YPL116W HOS3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) ZYRO0F10802g similar to uniprot|Q08601 Saccharomyces cerevisiae YOR197W MCA1 Putative cysteine protease similar to mammalian caspases ZYRO0F10824g similar to uniprot|P38934 Saccharomyces cerevisiae YOR198C BFR1 Component of mRNP complexes associated with polyribosomes implicated in secretion and nuclear segregation multicopy suppressor of BFA (Brefeldin A) sensitivity ZYRO0F10846g highly similar to uniprot|P15496 Saccharomyces cerevisiae YPL117C IDI1 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) catalyzes an essential activation step in the isoprenoid biosynthetic pathway required for viability ZYRO0F10868g uniprot|Q9UVE2 Zygosaccharomyces rouxii Hypothetical protein similar to YOR201C uniprot|P25270 Saccharomyces cerevisiae YOR201C MRM1 Ribose methyltransferase that modifies a functionally critical conserved nucleotide in mitochondrial 21S rRNA ZYRO0F10890g uniprot|Q9UVE1 Zygosaccharomyces rouxii HIS3 Imidazoleglycerol-phosphate dehydratase ZYRO0F10912g similar to uniprot|Q02950 Saccharomyces cerevisiae YPL118W MRP51; homolog group vGLR.3476 derived from GLR. 3476 ZYRO0F10934g similar to uniprot|P06634 Saccharomyces cerevisiae YOR204W DED1 ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase required for translation initiation of all yeast mRNAs mutations in human DEAD-box DBY are a frequent cause of male infertility ZYRO0F10956g highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits ZYRO0F10978g similar to uniprot|Q02948 Saccharomyces cerevisiae YPL120W VPS30 Protein required for sorting and delivery of soluble hydrolases to the vacuole ZYRO0F11000g similar to uniprot|Q08622 Saccharomyces cerevisiae YOR205C FMP38 The authentic non-tagged protein was localized to the mitochondria ZYRO0F11022g similar to uniprot|P39744 Saccharomyces cerevisiae YOR206W NOC2 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes as well as a nuclear complex with Noc3p that binds to 66S pre- ribosomes both complexes mediate intranuclear transport of ribosomal precursors ZYRO0F11044g similar to uniprot|P32489 Saccharomyces cerevisiae YPL121C MEI5 Meiosis specific protein involved in DMC1-dependent meiotic recombination forms heterodimer with Sae3p proposed to be an assembly factor for Dmc1p ZYRO0F11066g highly similar to uniprot|P22276 Saccharomyces cerevisiae YOR207C RET1 Second-largest subunit of RNA polymerase III which is responsible for the transcription of tRNA and 5S RNA genes and other low molecular weight RNAs ZYRO0F11088g highly similar to uniprot|P87331 Saccharomyces cerevisiae YPL122C ZYRO0F11110g highly similar to uniprot|P53622 Saccharomyces cerevisiae YDL145C COP1 Alpha subunit of COPI vesicle coatomer complex which surrounds transport vesicles in the early secretory pathway ZYRO0F11132g no similarity ZYRO0F11154g similar to uniprot|P53378 Saccharomyces cerevisiae YLR212C TUB4 Gamma-tubulin involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body ZYRO0F11176g similar to uniprot|Q12342 Saccharomyces cerevisiae YDL146W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck ZYRO0F11198g similar to uniprot|Q05789 Saccharomyces cerevisiae YLR211C Hypothetical ORF ZYRO0F11220g highly similar to uniprot|Q12250 Saccharomyces cerevisiae YDL147W RPN5 Essential, non-ATPase regulatory subunit of the 26S proteasome lid ZYRO0F11242g similar to uniprot|Q99207 Saccharomyces cerevisiae YDL148C NOP14 Nucleolar protein forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits also present in the small subunit processome complex which is required for processing of pre-18S rRNA ZYRO0F11264g similar to uniprot|Q12142 Saccharomyces cerevisiae YDL149W ATG9 Transmembrane protein involved in formation of Cvt and autophagic vesicles cycles between the pre-autophagosomal structure and other cytosolic punctate structures not found in autophagosomes ZYRO0F11286g similar to uniprot|P25441 Saccharomyces cerevisiae YDL150W RPC53 RNA polymerase III subunit C53 ZYRO0F11308g similar to uniprot|Q05842 Saccharomyces cerevisiae YDL153C SAS10 Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing essential nucleolar protein that when overproduced disrupts silencing ZYRO0F11330g similar to uniprot|Q12175 Saccharomyces cerevisiae YDL154W MSH5 Protein of the MutS family forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis msh5-Y823H mutation confers tolerance to DNA alkylating agents homologs present in C. elegans and humans ZYRO0F11352g similar to uniprot|P24870 Saccharomyces cerevisiae YDL155W CLB3 Involved in mitotic induction and perhaps in DNA replication and spindle assembly G(sub)2-specific B-type cyclin and uniprot|P24871 Saccharomyces cerevisiae YLR210W CLB4 ZYRO0F11374g similar to uniprot|Q12510 Saccharomyces cerevisiae YDL156W Hypothetical ORF ZYRO0F11396g highly similar to gnl|GLV|CAGL0I03520g Candida glabrata CAGL0I03520g and similar to YDL157C uniprot|Q12082 Saccharomyces cerevisiae YDL157C Hypothetical ORF ZYRO0F11418g similar to uniprot|P06784 Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response where it phosphorylates Fus3p and in the pseudohyphal/invasive growth pathway through phosphorylation of Kss1p phosphorylated by Ste11p degraded by ubiquitin pathway ZYRO0F11440g highly similar to uniprot|Q75BS4 Ashbya gossypii ACR197W DHH1 ATP-dependent RNA helicase DHH1 and similar to YDL160C uniprot|P39517 Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase stimulates mRNA decapping coordinates distinct steps in mRNA function and decay interacts with both the decapping and deadenylase complexes may have a role in mRNA export and translation ZYRO0F11462g similar to uniprot|Q05788 Saccharomyces cerevisiae YLR209C PNP1 purine nucleoside phosphorylase specifically metabolizes inosine and guanosine nucleosides ZYRO0F11484g highly similar to uniprot|Q04491 Saccharomyces cerevisiae YLR208W SEC13 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p Sec13p Sec16p Sec23p Sec24p Sec31p Sfb2p and Sfb3p) which is important for the formation of ER to Golgi transport vesicles ZYRO0F11506g similar to uniprot|Q05787 Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD) forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events ZYRO0F11528g some similarities with uniprot|Q3E829 Saccharomyces cerevisiae YDL160C-A Identified by homology to Ashbya gossypii ZYRO0F11550g some similarities with uniprot|Q12518 Saccharomyces cerevisiae YDL161W ENT1 ZYRO0F11572g similar to uniprot|P04819 Saccharomyces cerevisiae YDL164C CDC9 DNA ligase found in the nucleus and mitochondria an essential enzyme that joins Okazaki fragments during DNA replication also acts in nucleotide excision repair base excision repair and recombination ZYRO0F11594g similar to uniprot|P32339 Saccharomyces cerevisiae YLR205C HMX1 ER localized, heme-binding peroxidase involved in the degradation of heme ZYRO0F11616g similar to uniprot|P32335 Saccharomyces cerevisiae YLR203C MSS51 Protein required for the maturation and translation of COX1 mRNA involved in maturation of COX1 and COB mRNA ZYRO0F11638g highly similar to uniprot|P06100 Saccharomyces cerevisiae YDL165W CDC36 Component of the CCR4-NOT complex which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation basal transcription factor ZYRO0F11660g similar to uniprot|Q12055 Saccharomyces cerevisiae YDL166C FAP7 Essential nuclear protein involved in the oxidative stress response ZYRO0F11682g some similarities with uniprot|P32770 Saccharomyces cerevisiae YDL167C NRP1 ZYRO0F11704g highly similar to uniprot|P32771 Saccharomyces cerevisiae YDL168W SFA1 Long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) ZYRO0F11726g similar to uniprot|Q05779 Saccharomyces cerevisiae YLR201C FMP53 ZYRO0F11748g highly similar to uniprot|P52553 Saccharomyces cerevisiae YLR200W YKE2 Yeast nuclear gene ZYRO0F11770g weakly similar to uniprot|Q05778 Saccharomyces cerevisiae YLR199C Hypothetical ORF ZYRO0F11792g highly similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W SIK1 Component of the small (ribosomal) subunit (SSU) processosome that contains U3 snoRNA ZYRO0F11814g similar to uniprot|Q08919 Saccharomyces cerevisiae YPL176C ZYRO0F11836g similar to uniprot|P32363 Saccharomyces cerevisiae YPL175W SPT14 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates I) ZYRO0F11858g weakly similar to uniprot|P33420 Saccharomyces cerevisiae YPL174C NIP100 Large subunit of the dynactin complex which is involved in partitioning the mitotic spindle between mother and daughter cells putative ortholog of mammalian p150(glued) ZYRO0F11880g highly similar to uniprot|P06704 Saccharomyces cerevisiae YOR257W CDC31 Component of the spindle pole body (SPB) half-bridge required for SPB duplication in mitosis and meiosis II homolog of mammalian centrin interacts with Kar1p ZYRO0F11902g similar to uniprot|P36534 Saccharomyces cerevisiae YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit ZYRO0F11924g similar to uniprot|Q08702 Saccharomyces cerevisiae YOR258W HNT3 Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins similar to Aprataxin a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia ZYRO0F11946g highly similar to uniprot|P53549 Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for spindle pole body duplication localized mainly to the nucleus throughout the cell cycle ZYRO0F11968g similar to uniprot|P09032 Saccharomyces cerevisiae YOR260W GCD1 Gamma subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression ZYRO0F11990g similar to uniprot|P21592 Saccharomyces cerevisiae YPL172C COX10 Heme A:farnesyltransferase catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity human ortholog is associated with mitochondrial disorders ZYRO0F12012g highly similar to uniprot|Q75F44 Ashbya gossypii AAL116W RPN8 26S proteasome regulatory subunit RPN8 and similar to uniprot|Q08723 Saccharomyces cerevisiae YOR261C ZYRO0F12034g highly similar to uniprot|Q08726 Saccharomyces cerevisiae YOR262W Protein required for cell viability ZYRO0F12056g some similarities with uniprot|Q08729 Saccharomyces cerevisiae YOR264W ZYRO0F12078g highly similar to uniprot|P48606 Saccharomyces cerevisiae YOR265W RBL2 Protein involved in microtubule morphogenesis required for protection from excess free beta-tubulin proposed to be involved the folding of beta-tubulin ZYRO0F12100g similar to gnl|GLV|KLLA0C07557g Kluyveromyces lactis KLLA0C07557g and weakly similar to YOR266W uniprot|P38969 Saccharomyces cerevisiae YOR266W PNT1 Involved in targeting of proteins to the mitochondrial inner membrane Pentamidine resistance protein involved in pentamidine resistance protein ZYRO0F12122g similar to gnl|GLV|CAGL0C02893g Candida glabrata CAGL0C02893g and some similarites with YOR267C uniprot|Q07224 Saccharomyces cerevisiae YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H()- ATPase Pma1p in response to glucose metabolism plays a role in ion homeostasis ZYRO0F12144g similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism ZYRO0F12166g highly similar to uniprot|Q05027 Saccharomyces cerevisiae YMR236W TAF9 ZYRO0F12188g similar to uniprot|Q08754 Saccharomyces cerevisiae YOR299W BUD7 Protein involved in bud-site selection diploid mutants display an axial-like budding pattern ZYRO0F12210g similar to uniprot|Q05031 Saccharomyces cerevisiae YMR238W DFG5 Mannosidase essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis involved in filamentous growth homologous to Dcw1p ZYRO0F12232g similar to uniprot|Q08760 Saccharomyces cerevisiae YOR301W RAX1 Protein involved in bud site selection during bipolar budding localization requires Rax2p ZYRO0F12254g highly similar to uniprot|P08521 Saccharomyces cerevisiae YOR302W ZYRO0F12276g similar to uniprot|P07258 Saccharomyces cerevisiae YOR303W CPA1 Small subunit of carbamoyl phosphate synthetase ZYRO0F12298g conserved hypothetical protein ZYRO0F12320g highly similar to uniprot|Q08773 Saccharomyces cerevisiae YOR304W ISW2 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase component that with Itc1p forms a complex required for repression of a-specific genes INO1 and early meiotic genes during mitotic growth ZYRO0F12342g similar to uniprot|Q02555 Saccharomyces cerevisiae YMR239C RNT1 RNAase III cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end ZYRO0F12364g conserved hypothetical protein ZYRO0F12386g similar to uniprot|Q02554 Saccharomyces cerevisiae YMR240C CUS1 Protein required for assembly of U2 snRNP into the spliceosome forms a complex with Hsh49p and Hsh155p ZYRO0F12408g similar to uniprot|O14468 Saccharomyces cerevisiae YOR304C-A ZYRO0F12430g similar to uniprot|Q08774 Saccharomyces cerevisiae YOR305W Hypothetical ORF ZYRO0F12452g highly similar to uniprot|Q04013 Saccharomyces cerevisiae YMR241W YHM2 Yeast suppressor gene of HM mutant (abf2) DNA-binding protein mtDNA stabilizing protein mitochondrial inner membrane protein with low homology to RIM2 ZYRO0F12474g similar to uniprot|P22215 Saccharomyces cerevisiae YOR307C SLY41 multicopy suppressor of ypt1 deletion homolog of chloroplast phosphate transporter ZYRO0F12496g weakly similar to uniprot|Q12420 Saccharomyces cerevisiae YOR308C SNU66 66kD U4/U6.U5 snRNP associated protein ZYRO0F12518g similar to uniprot|Q12499 Saccharomyces cerevisiae YOR310C NOP58 Protein involved in pre-rRNA processing 18S rRNA synthesis and snoRNA synthesis component of the small subunit processome complex which is required for processing of pre-18S rRNA ZYRO0F12540g similar to uniprot|Q12382 Saccharomyces cerevisiae YOR311C HSD1 Endoplasmic reticulum (ER)-resident membrane protein overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation ZYRO0F12562g highly similar to uniprot|P47913 Saccharomyces cerevisiae YOR312C ZYRO0F12584g similar to uniprot|P09937 Saccharomyces cerevisiae YOR313C SPS4 Protein whose expression is induced during sporulation not required for sporulation heterologous expression in E. coli induces the SOS response that senses DNA damage ZYRO0F12606g similar to uniprot|P20107 Saccharomyces cerevisiae YMR243C ZRC1 and to uniprot|P32798 Saccharomyces cerevisiae YOR316C COT1 ZYRO0F12628g similar to uniprot|Q04018 Saccharomyces cerevisiae YMR244W Hypothetical ORF ZYRO0F12650g similar to uniprot|P25619 Saccharomyces cerevisiae YCR021C HSP30 Hydrophobic plasma membrane localized stress-responsive protein that negatively regulates the H()-ATPase Pma1p induced by heat shock ethanol treatment weak organic acid glucose limitation and entry into stationary phase ZYRO0F12672g similar to uniprot|Q3E846 Saccharomyces cerevisiae YMR244C-A Hypothetical ORF ZYRO0F12694g similar to uniprot|P30624 Saccharomyces cerevisiae YOR317W FAA1 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids involved in the activation of imported fatty acids not required for growth on nonfermentable carbon sources essential for stationary phase and similar to YMR246W uniprot|P47912 Saccharomyces cerevisiae YMR246W FAA4 Long chain fatty acyl-CoA synthetase and similar to YIL009W uniprot|P39002 Saccharomyces cerevisiae YIL009W FAA3 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery ZYRO0F12716g similar to uniprot|Q99181 Saccharomyces cerevisiae YOR319W ZYRO0F12738g similar to uniprot|Q12096 Saccharomyces cerevisiae YOR320C GNT1 N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus ZYRO0F12760g similar to uniprot|Q04781 Saccharomyces cerevisiae YMR247C Hypothetical ORF ZYRO0F12804g similar to uniprot|P21182 Saccharomyces cerevisiae YOL052C SPE2 S-adenosylmethionine decarboxylase ZYRO0F12826g similar to uniprot|Q04792 Saccharomyces cerevisiae YMR250W GAD1 Glutamate decarboxylase converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism involved in response to oxidative stress ZYRO0F12848g highly similar to uniprot|Q05827 Saccharomyces cerevisiae YMR251W-A ZYRO0F12870g similar to uniprot|P38197 Saccharomyces cerevisiae YBL036C Single-domain racemase possibly non-specific due to the lack of the second domain which presumably determines specificity ZYRO0F12892g similar to uniprot|P38065 Saccharomyces cerevisiae YBL037W APL3 clathrin Associated Protein complex Large subunit Large subunit of clathrin associated protein complex ZYRO0F12914g highly similar to uniprot|P38251 Saccharomyces cerevisiae YBR087W RFC5 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon ZYRO0F12936g highly similar to uniprot|Q1ET04 Saccharomyces bayanus MRPL16 Mitochondrial ribosomal protein large subunit and highly similar to YBL038W uniprot|P38064 Saccharomyces cerevisiae YBL038W MRPL16 Mitochondrial ribosomal protein of the large subunit ZYRO0F12958g similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions ZYRO0F12980g similar to uniprot|P38170 Saccharomyces cerevisiae YBL097W BRN1 Essential protein required for chromosome condensation likely to function as an intrinsic component of the condensation machinery may influence multiple aspects of chromosome transmission and dynamics ZYRO0F13002g similar to uniprot|P38169 Saccharomyces cerevisiae YBL098W BNA4 Kynurenine 3-mono oxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway ZYRO0F13024g similar to uniprot|P32795 Saccharomyces cerevisiae YPR024W YME1 Mitochondrial inner membrane protease of the AAA family responsible for degradation of unfolded or misfolded mitochondrial gene products mutation causes an elevated rate of mitochondrial turnover ZYRO0F13046g similar to uniprot|P37366 Saccharomyces cerevisiae YPR025C CCL1 Cyclin associated with protein kinase Kin28p which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters ZYRO0F13068g highly similar to uniprot|P07251 Saccharomyces cerevisiae YBL099W ATP1 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis ZYRO0F13090g similar to uniprot|P48016 Saccharomyces cerevisiae YPR026W ATH1 Vacuolar acid trehalase required for trehalose utilization ZYRO0F13134g similar to uniprot|Q12402 Saccharomyces cerevisiae YPR028W YOP1 Protein that regulates vesicular traffic in stressed cells either to facilitate membrane turnover or to decrease unnecessary secretion ZYRO0F13156g similar to uniprot|Q12028 Saccharomyces cerevisiae YPR029C APL4 Gamma-adaptin large subunit of the clathrin-associated protein (AP) complex ZYRO0F13178g weakly similar to uniprot|P38167 Saccharomyces cerevisiae YBL101C ECM21 Non-essential protein of unknown function promoter contains several Gcn4p binding elements ZYRO0F13200g highly similar to uniprot|P38166 Saccharomyces cerevisiae YBL102W ZYRO0F13222g some similarities with uniprot|P38165 Saccharomyces cerevisiae YBL103C RTG3 Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein Rtg1p to activate the retrograde (RTG) and TOR pathways ZYRO0F13244g similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment ZYRO0F13266g similar to uniprot|Q12311 Saccharomyces cerevisiae YPR031W NTO1 Component of the histone acetyltransferase complex ZYRO0F13288g similar to uniprot|P38164 Saccharomyces cerevisiae YBL104C Hypothetical ORF ZYRO0F13310g some similarities with uniprot|P24583 Saccharomyces cerevisiae YBL105C PKC1 Protein Kinase C ZYRO0F13332g similar to uniprot|Q12038 Saccharomyces cerevisiae YPR032W SRO7 Suppressor of rho3 yeast homolog of the Drosphila tumor suppressor lethal giant larvae or similar to YBL106C uniprot|P38163 Saccharomyces cerevisiae YBL106C SRO77 Suppressor of defect in the small GTPase Rho3p yeast homolog of the Drosphila tumor suppressor lethal giant larvae ZYRO0F13354g similar to uniprot|P38162 Saccharomyces cerevisiae YBL107C Hypothetical ORF ZYRO0F13376g similar to uniprot|P47125 Saccharomyces cerevisiae YJR078W BNA2 Tryptophan 2 3-dioxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway ZYRO0F13398g highly similar to uniprot|P07263 Saccharomyces cerevisiae YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase encoded by a single nuclear gene that specifies two messages efficient mitochondrial localization requires both a presequence and an amino-terminal sequence ZYRO0F13420g similar to uniprot|P47127 Saccharomyces cerevisiae YJR080C FMP26 The authentic non-tagged protein was localized to the mitochondria ZYRO0F13442g similar to uniprot|P36125 Saccharomyces cerevisiae YKR030W GMH1 Golgi membrane protein of unknown function interacts with Gea1p and Gea2p required for localization of Gea2p computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting ZYRO0F13464g no similarity ZYRO0F13486g similar to uniprot|P36126 Saccharomyces cerevisiae YKR031C SPO14 Phospholipase D catalyzes the hydrolysis of phosphatidylcholine producing choline and phosphatidic acid involved in Sec14p-independent secretion required for meiosis and spore formation differently regulated in secretion and meiosis ZYRO0F13508g weakly similar to uniprot|P53309 Saccharomyces cerevisiae YGR241C YAP1802 Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin; member of clathrin assembly polypeptide AP180 family and weakly similar to uniprot|P38856 Saccharomyces cerevisiae YHR161C YAP1801 Yeast Assembly Polypeptide member of AP180 protein family binds Pan1p and clathrin clathrin assembly protein ZYRO0F13530g similar to uniprot|P53311 Saccharomyces cerevisiae YGR243W FMP43 ZYRO0F13552g similar to uniprot|P41903 Saccharomyces cerevisiae YJR019C TES1 Thioesterase peroxisomal acyl-CoA thioesterase ZYRO0F13574g weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for repression of middle sporulation genes specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p ZYRO0F13596g highly similar to uniprot|P53312 Saccharomyces cerevisiae YGR244C LSC2 Beta subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate ZYRO0F13618g similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism ZYRO0F13662g similar to uniprot|Q03768 Saccharomyces cerevisiae YDR152W GIR2 RWD domain containing protein of unknown function ZYRO0F13684g highly similar to uniprot|Q6Q5U2 Saccharomyces cerevisiae YDR153C ENT5 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p clathrin adaptor complex AP-1 and clathrin ZYRO0F13706g highly similar to uniprot|P14832 Saccharomyces cerevisiae YDR155C CPR1 Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds the drug cyclosporin A ZYRO0F13728g similar to gnl|GLV|CAGL0E01155g Candida glabrata CAGL0E01155g and weakly similar to YDR156W uniprot|P50106 Saccharomyces cerevisiae YDR156W RPA14 RNA polymerase I subunit A14 ZYRO0F13750g highly similar to uniprot|P13663 Saccharomyces cerevisiae YDR158W HOM2 Aspartic beta semi-aldehyde dehydrogenase catalyzes the second step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis ZYRO0F13772g similar to uniprot|Q12367 Saccharomyces cerevisiae YLR137W Hypothetical ORF ZYRO0F13794g similar to uniprot|P46674 Saccharomyces cerevisiae YDR159W SAC3 Nuclear pore-associated protein forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus ZYRO0F13816g similar to uniprot|Q99271 Saccharomyces cerevisiae YLR138W NHA1 Na+/H+ antiporter ZYRO0F13838g similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes ZYRO0F13860g similar to uniprot|Q03771 Saccharomyces cerevisiae YDR161W interacts with PP2C ZYRO0F13882g similar to uniprot|Q12163 Saccharomyces cerevisiae YDR162C NBP2 Protein involved in the HOG (high osmolarity glycerol) pathway negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex found in the nucleus and cytoplasm contains an SH3 domain that binds Pbs2p ZYRO0F13904g similar to uniprot|Q03772 Saccharomyces cerevisiae YDR163W ZYRO0F13926g similar to uniprot|P42900 Saccharomyces cerevisiae YLR139C SLS1 Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV coordinates expression of mitochondrially-encoded genes may facilitate delivery of mRNA to membrane-bound translation machinery ZYRO0F13948g weakly similar to uniprot|Q02983 Saccharomyces cerevisiae YLR141W RRN5 Transcription factor member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p involved in transcription of rDNA by RNA polymerase I ZYRO0F13970g similar to uniprot|P09368 Saccharomyces cerevisiae YLR142W PUT1 proline oxidase ZYRO0F14014g similar to uniprot|Q07261 Saccharomyces cerevisiae YLR143W Hypothetical ORF ZYRO0F14036g conserved hypothetical protein ZYRO0F14058g similar to uniprot|P30619 Saccharomyces cerevisiae YDR164C SEC1 Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function ZYRO0F14080g similar to uniprot|Q07268 Saccharomyces cerevisiae YLR144C ACF2 Intracellular beta-1 3-endoglucanase expression is induced during sporulation may have a role in cortical actin cytoskeleton assembly ZYRO0F14102g similar to gnl|GLV|KLLA0D17072g Kluyveromyces lactis KLLA0D17072g and weakly similar to YLR145W uniprot|Q12530 Saccharomyces cerevisiae YLR145W RMP1 Protein required for cell viability component of RNase MRP which is involved in RNA processing in mitochondria ZYRO0F14124g similar to uniprot|Q12455 Saccharomyces cerevisiae YLR146C SPE4 Spermine Synthase ZYRO0F14146g similar to uniprot|Q03774 Saccharomyces cerevisiae YDR165W TRM82 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA ZYRO0F14168g conserved hypothetical protein ZYRO0F14190g similar to uniprot|P89102 Saccharomyces cerevisiae YDR166C SEC5 Essential 107kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis ZYRO0F14212g highly similar to uniprot|P43321 Saccharomyces cerevisiae YLR147C SMD3 involved in snRNP biogenesis and pre-mRNA splicing encodes a core snRNP protein ZYRO0F14234g similar to uniprot|P27801 Saccharomyces cerevisiae YLR148W PEP3 Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins required for vacuolar biogenesis forms complex with Pep5p that mediates protein transport to the vacuole ZYRO0F14256g similar to uniprot|Q12030 Saccharomyces cerevisiae YDR167W TAF10 Subunit (145 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification ZYRO0F14278g similar to uniprot|P06101 Saccharomyces cerevisiae YDR168W CDC37 Essential Hsp90p co-chaperone necessary for passage through the START phase of the cell cycle ZYRO0F14300g similar to uniprot|Q99296 Saccharomyces cerevisiae YLR149C Hypothetical ORF ZYRO0F14322g similar to uniprot|Q12427 Saccharomyces cerevisiae YDR169C STB3 Protein ZYRO0F14344g similar to uniprot|P39015 Saccharomyces cerevisiae YLR150W STM1 Protein that binds quadruplex nucleic acids multicopy suppressor of tom1 and pop2 mutations acts with Cdc13p to maintain telomere structure ZYRO0F14366g similar to uniprot|Q12524 Saccharomyces cerevisiae YLR151C PCD1 Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids ZYRO0F14388g similar to uniprot|P54072 Saccharomyces cerevisiae YLR152C Hypothetical ORF ZYRO0F14410g highly similar to uniprot|P52910 Saccharomyces cerevisiae YLR153C ACS2 Acetyl-coA synthetase isoform required for growth on glucose expressed under anaerobic conditions ZYRO0F14432g similar to uniprot|P11075 Saccharomyces cerevisiae YDR170C SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi intra-Golgi transport and ER-to-Golgi transport found in the cytoplasm and on Golgi-associated coated vesicles ZYRO0F14454g conserved hypothetical protein ZYRO0F14498g some similarities with uniprot|Q12329 Saccharomyces cerevisiae YDR171W HSP42 Small cytosolic stress-induced chaperone that forms barrel-shaped oligomers and suppresses the aggregation of non-native proteins oligomer dissociation is not required for function involved in cytoskeleton reorganization after heat shock ZYRO0F14520g uniprot|Q9HGI4 Zygosaccharomyces rouxii SUP35 Eukaryotic peptide chain release factor GTP-binding subunit ZYRO0F14542g similar to uniprot|P07250 Saccharomyces cerevisiae YDR173C ARG82 Protein involved in regulation of arginine-responsive and Mcm1p-dependent genes has a dual-specificity inositol polyphosphate kinase activity required for regulation of phosphate- and nitrogen- responsive genes ZYRO0F14564g similar to uniprot|Q08913 Saccharomyces cerevisiae YOR390W Hypothetical ORF ZYRO0F14586g highly similar to uniprot|P02365 Saccharomyces cerevisiae YPL090C RPS6A and to uniprot|P02365 Saccharomyces cerevisiae YBR181C RPS6B Proteins component of the small (40S) ribosomal subunit ZYRO0F14608g highly similar to uniprot|P41921 Saccharomyces cerevisiae YPL091W GLR1 Cytosolic and mitochondrial glutathione oxidoreductase converts oxidized glutathione to reduced glutathione ZYRO0F14630g similar to uniprot|Q2VQ77 Saccharomyces cerevisiae YPL092W SSU1 ZYRO0F14652g similar to uniprot|P38125 Saccharomyces cerevisiae YBR180W DTR1 Multidrug resistance dityrosine transporter of the major facilitator superfamily essential for spore wall synthesis facilitates the translocation of bisformyl dityrosine through the prospore membrane ZYRO0F14674g highly similar to uniprot|Q02892 Saccharomyces cerevisiae YPL093W NOG1 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis member of the ODN family of nucleolar G-proteins ZYRO0F14696g similar to uniprot|P21825 Saccharomyces cerevisiae YPL094C ZYRO0F14718g similar to uniprot|P38297 Saccharomyces cerevisiae YBR179C FZO1 Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome contains N-terminal GTPase domain ZYRO0F14740g similar to uniprot|P38295 Saccharomyces cerevisiae YBR177C EHT1 Possible serine hydrolase may be involved in lipid metabolism null mutant slightly temperature sensitive at 37C and similar to YPL095c uniprot|Q02891 Saccharomyces cerevisiae YPL095C Hypothetical ORF and weakly similar to YMR210w uniprot|Q03649 Saccharomyces cerevisiae YMR210W Hypothetical ORF ZYRO0F14762g similar to uniprot|Q02890 Saccharomyces cerevisiae YPL096W PNG1 de-N-glycosylation enzyme peptide:N-glycanase ZYRO0F14784g similar to uniprot|P48527 Saccharomyces cerevisiae YPL097W ZYRO0F14806g similar to uniprot|Q02889 Saccharomyces cerevisiae YPL098C Hypothetical ORF ZYRO0F14828g similar to gnl|GLV|KLLA0E24332g Kluyveromyces lactis KLLA0E24332g and some similarities with YPL099C uniprot|Q02888 Saccharomyces cerevisiae YPL099C FMP14 The authentic non-tagged protein was localized to the mitochondria ZYRO0F14850g similar to uniprot|Q02887 Saccharomyces cerevisiae YPL100W ATG21 Phosphatidylinositol 3 5-bisphosphate-binding protein required for maturation of pro-aminopeptidase I predicted to fold as a seven-bladed beta-propeller displays punctate cytoplasmic localization ZYRO0F14872g similar to uniprot|Q02884 Saccharomyces cerevisiae YPL101W ELP4 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity ZYRO0F14894g similar to uniprot|Q02883 Saccharomyces cerevisiae YPL103C ZYRO0F14916g similar to uniprot|P38122 Saccharomyces cerevisiae YBR176W ECM31 Ketopantoate hydroxymethyltransferase required for pantothenic acid biosynthesis converts 2-oxoisovalerate into 2-dehydropantoate ZYRO0F14938g similar to uniprot|P15179 Saccharomyces cerevisiae YPL104W Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene ZYRO0F14960g highly similar to uniprot|P38123 Saccharomyces cerevisiae YBR175W SWD3 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres ZYRO0F14982g highly similar to uniprot|P38293 Saccharomyces cerevisiae YBR173C UMP1 Short-lived chaperone required for correct maturation of the 20S proteasome degraded by proteasome upon completion of its assembly involved in ubiquitin-mediated proteolysis mutant defective in degradation of short-lived proteins ZYRO0F15004g weakly similar to uniprot|P32909 Saccharomyces cerevisiae YBR172C SMY2 partial suppressor of myo2-66 Kinesin-related protein suppressing myosin defects (MYO2) and to uniprot|Q02875 YPL105c ZYRO0F15026g highly similar to uniprot|P33754 Saccharomyces cerevisiae YBR171W SEC66 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER ZYRO0F15048g similar to uniprot|P33755 Saccharomyces cerevisiae YBR170C NPL4 Endoplasmic reticulum and nuclear membrane protein forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation ZYRO0F15092g similar to uniprot|P40152 Saccharomyces cerevisiae YNL217W Hypothetical ORF ZYRO0F15114g similar to uniprot|Q07688 Saccharomyces cerevisiae YDL235C YPD1 Phosphorelay intermediate protein phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus ZYRO0F15136g similar to uniprot|P40151 Saccharomyces cerevisiae YNL218W MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome interacts functionally with DNA polymerase delta homolog of human Werner helicase interacting protein (WHIP) ZYRO0F15158g similar to uniprot|P19881 Saccharomyces cerevisiae YDL236W PHO13 Alkaline phosphatase specific for p-nitrophenyl phosphate involved in dephosphorylation of histone II-A and casein ZYRO0F15180g similar to uniprot|P53868 Saccharomyces cerevisiae YNL219C ALG9 catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides mannosyltransferase ZYRO0F15202g highly similar to uniprot|P80210 Saccharomyces cerevisiae YNL220W ADE12 Adenylosuccinate synthase catalyzes the first committed step in the 'de novo' biosynthesis of adenosine ZYRO0F15224g similar to uniprot|P41812 Saccharomyces cerevisiae YNL221C POP1 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P ZYRO0F15268g similar to uniprot|Q6B312 Saccharomyces cerevisiae YDL237W Hypothetical ORF ZYRO0F15290g similar to uniprot|Q07729 Saccharomyces cerevisiae YDL238C GUD1 Guanine deaminase a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures ZYRO0F15312g highly similar to uniprot|P53538 Saccharomyces cerevisiae YNL222W SSU72 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p exhibits intrinsic phosphatase activity affects start site selection in vivo Nuclear zinc-finger motif containing protein. ZYRO0F15334g similar to uniprot|P53867 Saccharomyces cerevisiae YNL223W ATG4 Cysteine protease required for autophagy cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p ZYRO0F15356g weakly similar to uniprot|P53866 Saccharomyces cerevisiae YNL224C Hypothetical ORF ZYRO0F15378g weakly similar to uniprot|Q07732 Saccharomyces cerevisiae YDL239C ADY3 Protein required for spore wall formation thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components potentially phosphorylated by Cdc28p ZYRO0F15400g similar to uniprot|P53863 Saccharomyces cerevisiae YNL227C JJJ1 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain ZYRO0F15422g similar to uniprot|P23202 Saccharomyces cerevisiae YNL229C URE2 Nitrogen catabolite repression regulator that acts by inhibition of GLN3 transcription in good nitrogen source altered form of Ure2p creates [URE3] prion ZYRO0F15444g similar to uniprot|P53861 Saccharomyces cerevisiae YNL230C ELA1 Elongin A F-box protein that forms a heterodimer with Elc1p and participates in transcription elongation ZYRO0F15466g highly similar to uniprot|P53860 Saccharomyces cerevisiae YNL231C PDR16 Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p localizes to lipid particles and microsomes controls levels of various lipids may regulate lipid synthesis homologous to Pdr17p ZYRO0F15488g similar to uniprot|P53859 Saccharomyces cerevisiae YNL232W CSL4 Subunit of the exosome which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation ZYRO0F15510g some similarities with uniprot|P53858 Saccharomyces cerevisiae YNL233W BNI4 Targeting subunit for Glc7p protein phosphatase localized to the bud neck required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p ZYRO0F15532g similar to uniprot|Q75E71 Ashbya gossypii ABL201W ABL201Wp and weakly similar to YNL234W uniprot|P53857 Saccharomyces cerevisiae YNL234W Similar to globins and has a functional heme-binding domain involved in glucose signaling or metabolism regulated by Rgt1p ZYRO0F15554g similar to uniprot|P32259 YNL236W Saccharomyces cerevisiae SIN4 involved in positive and negative regulation of transcription ZYRO0F15576g similar to uniprot|P53584 Saccharomyces cerevisiae YNL237W ZYRO0F15598g similar to uniprot|P13134 YNL238W Saccharomyces cerevisiae KEX2 Subtilisin-like protease (proprotein convertase) ZYRO0F15620g highly similar to gnl|GLV|CAGL0J07568g Candida glabrata CAGL0J07568g and similar to YNL239W uniprot|Q01532 Saccharomyces cerevisiae YNL239W LAP3 Aminopeptidase of cysteine protease family has a DNA binding activity and acts as bleomycin hydrolase in vitro transcription is regulated by galactose via Gal4p ZYRO0F15642g similar to uniprot|P23503 YNL240C Saccharomyces cerevisiae NAR1 Nuclear architecture related protein component of the cytosolic iron-sulfur (FeS) protein assembly machinery ZYRO0F15664g highly similar to uniprot|P38716 Saccharomyces cerevisiae YHR112C Hypothetical ORF ZYRO0F15686g highly similar to uniprot|P11412 YNL241C Saccharomyces cerevisiae ZWF1 Glucose-6-phosphate dehydrogenase ZYRO0F15708g similar to uniprot|P35688 Saccharomyces cerevisiae YDL240W LRG1 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity appears to specifically regulate 1 3-beta-glucan synthesis ZYRO0F15730g similar to uniprot|P53855 YNL242W Saccharomyces cerevisiae ATG2 Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy ZYRO0F15752g weakly similar to uniprot|P21691 Saccharomyces cerevisiae YKR101W SIR1 Protein involved in repression of transcription at the silent mating-type loci HML and HMR recruitment to silent chromatin requires interactions with Orc1p and with Sir4p through a common Sir1p domain binds to centromeric chromatin ZYRO0F15774g similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase ZYRO0F15796g no similarity ZYRO0F15818g similar to uniprot|Q6B2C0 Saccharomyces cerevisiae YCR039C MATALPHA2 Homeobox-domain containing protein which in haploid cells acts with Mcm1p to repress a-specific genes in diploid cells Alpha2p acts together with A1p to repress transcription of haploid-specific genes ZYRO0F15840g similar to uniprot|P01365 Saccharomyces cerevisiae YCR040W MATALPHA1 Transcriptional co-activator involved in regulation of mating-type-specific gene expression targets the transcription factor Mcm1p to the promoters of alpha-specific genes one of two genes encoded by the alpha mating type cassette ZYRO0F15862g some similarities with uniprot|P33338 Saccharomyces cerevisiae YNL243W SLA2 Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization adaptor protein that links actin to clathrin and endocytosis present in the actin cortical patch of the emerging bud tip dimer in vivo ZYRO0F15884g highly similar to uniprot|P32911 Saccharomyces cerevisiae YNL244C SUI1 translation initiation factor eIF1 ZYRO0F15906g similar to uniprot|P53854 Saccharomyces cerevisiae YNL245C CWC25 Component of a complex containing Cef1p, involved in pre-mRNA splicing; has similarity to S. pombe Cwf25p ZYRO0F15928g similar to uniprot|P53852 Saccharomyces cerevisiae YNL247W Protein required for cell viability ZYRO0F15950g similar to uniprot|P47139 Saccharomyces cerevisiae YJR098C Hypothetical ORF ZYRO0F15972g similar to uniprot|P47138 Saccharomyces cerevisiae YJR097W JJJ3 Protein required along with Dph1p Dph2p Kti11p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) contains a DnaJ-like domain ZYRO0F15994g highly similar to uniprot|Q01080 Saccharomyces cerevisiae YNL248C RPA49 RNA polymerase I subunit A49 ZYRO0F16016g similar to uniprot|P53583 Saccharomyces cerevisiae YNL249C MPA43 Mitochondrial protein ZYRO0F16038g similar to uniprot|P12753 Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex with Mre11p and Xrs2p involved in processing double-strand DNA breaks in vegetative cells initiation of meiotic DSBs telomere maintenance and nonhomologous end joining ZYRO0F16060g similar to uniprot|P53617 Saccharomyces cerevisiae YNL251C NRD1 RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p) required for transcription termination and 3' end maturation of nonpolyadenylated RNAs ZYRO0F16082g similar to uniprot|P36528 Saccharomyces cerevisiae YNL252C MRPL17 Mitochondrial ribosomal protein of the large subunit ZYRO0F16104g similar to uniprot|P53851 Saccharomyces cerevisiae YNL253W TEX1 transcription export complex component ZYRO0F16126g some similarities with uniprot|P53850 Saccharomyces cerevisiae YNL254C Hypothetical ORF ZYRO0F16148g highly similar to uniprot|P53849 Saccharomyces cerevisiae YNL255C ZYRO0F16170g similar to uniprot|P53848 Saccharomyces cerevisiae YNL256W FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway has dihydropteroate synthetase dihydro-6-hydroxymethylpterin pyrophosphokinase and dihydroneopterin aldolase activities ZYRO0F16192g similar to uniprot|P53318 Saccharomyces cerevisiae YGR255C COQ6 Putative flavin-dependent monooxygenase involved in ubiquinone (Coenzyme Q) biosynthesis located on the matrix side of the mitochondrial inner membrane ZYRO0F16214g conserved hypothetical protein ZYRO0F16236g similar to uniprot|P54857 Saccharomyces cerevisiae YDR058C TGL2 Triglyceride Lipase ZYRO0F16258g similar to uniprot|P38717 Saccharomyces cerevisiae YNL257C SIP3 Protein that activates transcription through interaction with DNA-bound Snf1p C-terminal region has a putative leucine zipper motif potential Cdc28p substrate and to uniprot|P38851 Saccharomyces cerevisiae YHR155W YSP1 Hypothetical ORF ZYRO0F16302g similar to uniprot|P53847 Saccharomyces cerevisiae YNL258C DSL1 Endoplasmic reticulum (ER)-localized peripheral membrane protein required for Golgi-to-ER retrograde traffic component of the ER target site that interacts with coatomer the major component of the COPI vesicle protein coat ZYRO0F16324g highly similar to uniprot|P38636 Saccharomyces cerevisiae YNL259C ZYRO0F16346g similar to uniprot|P53846 Saccharomyces cerevisiae YNL260C Protein required for cell viability ZYRO0F16368g some similarities with uniprot|P38852 Saccharomyces cerevisiae YHR156C LIN1 Nuclear protein that physically interacts with Irr1p a component of the cohesin complex may link together proteins involved in chromosome segregation mRNA splicing and DNA replication ZYRO0F16390g highly similar to uniprot|P50874 Saccharomyces cerevisiae YNL261W ORC5 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing ZYRO0F16412g highly similar to uniprot|P21951 Saccharomyces cerevisiae YNL262W POL2 Catalytic subunit of DNA polymerase epsilon one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity also involved in DNA synthesis during DNA repair ZYRO0F16434g similar to uniprot|P53845 Saccharomyces cerevisiae YNL263C ZYRO0F16456g weakly similar to uniprot|P52868 Saccharomyces cerevisiae YGL128C ZYRO0F16478g similar to uniprot|P53844 Saccharomyces cerevisiae YNL264C PDR17 Phosphatidylinositol transfer protein (PITP) downregulates Plb1p-mediated turnover of phosphatidylcholine found in the cytosol and microsomes homologous to Pdr16p deletion affects phospholipid composition ZYRO0F16500g similar to uniprot|P53120 Saccharomyces cerevisiae YGL140C Hypothetical ORF ZYRO0F16522g similar to uniprot|P53044 Saccharomyces cerevisiae YGR048W UFD1 Protein that interacts with Cdc48p and Npl4p involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation involved in transporting proteins from the ER to the cytosol ZYRO0F16544g similar to uniprot|P33339 Saccharomyces cerevisiae YGR047C ZYRO0F16566g similar to uniprot|P53843 Saccharomyces cerevisiae YNL265C IST1 Putative translation initiation factor as suggested by computational analysis of large-scale protein-protein interaction data ZYRO0F16588g similar to uniprot|P53230 Saccharomyces cerevisiae YGR046W Essential protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p ZYRO0F16610g similar to uniprot|P39104 Saccharomyces cerevisiae YNL267W PIK1 Phosphatidylinositol 4-kinase catalyzes first step in the biosynthesis of phosphatidylinositol-4 5-biphosphate may control cytokineses through the actin cytoskeleton ZYRO0F16632g similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W LYP1 Lysine permease one of three amino acid permeases (Alp1p Can1p Lyp1p) responsible for uptake of cationic amino acids ZYRO0F16654g similar to uniprot|P04817 Saccharomyces cerevisiae YEL063C CAN1 Plasma membrane arginine permease requires phosphatidyl ethanolamine (PE) for localization exclusively associated with lipid rafts mutation confers canavanine resistance ZYRO0F16676g some similarities with uniprot|P41832 Saccharomyces cerevisiae YNL271C BNI1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNR1 ZYRO0F16698g weakly similar to uniprot|P17065 Saccharomyces cerevisiae YNL272C SEC2 Guanyl-nucleotide exchange factor for the small G-protein Sec4p located on cytoplasmic vesicles essential for post-Golgi vesicle transport ZYRO0F16720g similar to uniprot|P39981 Saccharomyces cerevisiae YEL064C AVT2 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ZYRO0F16742g similar to uniprot|P53840 Saccharomyces cerevisiae YNL273W TOF1 Protein that interacts with topoisomerase I ZYRO0F16764g conserved hypothetical protein ZYRO0F16786g weakly similar to uniprot|P13365 Saccharomyces cerevisiae YAL040C ZYRO0F16808g similar to uniprot|Q12232 Saccharomyces cerevisiae YOR154W Hypothetical ORF ZYRO0F16830g similar to uniprot|P23255 Saccharomyces cerevisiae YCR042C TAF2 TFIID subunit (150 kDa) involved in RNA polymerase II transcription initiation ZYRO0F16852g similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism ZYRO0F16874g similar to uniprot|P53839 Saccharomyces cerevisiae YNL274C Putative hydroxyisocaproate dehydrogenase ZYRO0F16896g similar to uniprot|P25361 Saccharomyces cerevisiae YCR043C Hypothetical ORF ZYRO0F16918g highly similar to uniprot|P53838 Saccharomyces cerevisiae YNL275W ZYRO0F16940g similar to uniprot|P25625 Saccharomyces cerevisiae YCR044C PER1 Vacuolar membrane protein that seems to be involved in Mn2 homeostasis mutant is dependent on activation of the unfolded protein response pathway for viability ZYRO0F16962g weakly similar to uniprot|P40014 Saccharomyces cerevisiae YER018C ZYRO0F16984g similar to uniprot|P40015 Saccharomyces cerevisiae YER019W ISC1 Inositol phosphosphingolipid phospholipase C hydrolyzes inositolphosphosphingolipids activated by phosphatidylserine cardiolipin and phosphatidylglycerol mediates Na and Li halotolerance contains a P loop-like domain ZYRO0F17006g similar to uniprot|Q06321 Saccharomyces cerevisiae YLR189C ATG26 UDP-glucose:sterol glucosyltransferase conserved enzyme involved in synthesis of sterol glucoside membrane lipids involved in autophagy ZYRO0F17028g similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway ZYRO0F17050g similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane mediates export of peptides generated upon proteolysis of mitochondrial proteins plays a role in the regulation of cellular resistance to oxidative stress ZYRO0F17072g similar to Saccharomyces cerevisiae YLR187W SKG3 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate And to YNL278W uniprot|P53836 Saccharomyces cerevisiae YNL278W CAF120 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation ZYRO0F17094g similar to uniprot|P53835 Saccharomyces cerevisiae YNL279W PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating predicted to have 5 transmembrane segments and a coiled coil domain localizes to the shmoo tip regulated by Ste12p ZYRO0F17116g highly similar to uniprot|Q06287 Saccharomyces cerevisiae YLR186W EMG1 Protein required for the maturation of the 18S rRNA and for 40S ribosome production associated with spindle/microtubules nuclear localization depends on physical interaction with Nop14p may bind snoRNAs ZYRO0F17138g similar to uniprot|Q04377 Saccharomyces cerevisiae YDR499W LCD1 Essential protein required for the DNA integrity checkpoint pathways interacts physically with Mec1p putative homolog of S. pombe Rad26 and human ATRIP ZYRO0F17160g highly similar to uniprot|P49166 Saccharomyces cerevisiae YLR185W RPL37A protein and to uniprot|P51402 Saccharomyces cerevisiae YDR500C RPL37B protein, components of the large (60S) ribosomal subunit ZYRO0F17182g similar to uniprot|Q04383 Saccharomyces cerevisiae YDR501W PLM2 Plasmid Maintenance and to uniprot|Q06266 YLR183C Saccharomyces cerevisiae TOS4 Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF ZYRO0F17204g similar to uniprot|P09959 Saccharomyces cerevisiae YLR182W SWI6 Transcription cofactor forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition involved in meiotic gene expression localization regulated by phosphorylation potential Cdc28p substrate ZYRO0F17226g weakly similar to uniprot|Q07057 Saccharomyces cerevisiae YLR181C VTA1 Protein involved in endosomal protein sorting binds to Vps20 and Vps4 and may regulate Vps4function has coiled-coil domains mutants show class E vacuolar-protein sorting defects ZYRO0F17248g highly similar to uniprot|P10659 Saccharomyces cerevisiae YDR502C and to uniprot|P19358 SAM1 S-adenosylmethionine synthetase catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine one of two differentially regulated isozymes (Sam1p and Sam2p) ZYRO0F17270g similar to uniprot|Q04396 Saccharomyces cerevisiae YDR503C LPP1 Lipid phosphate phosphatase catalyzes Mg(2)-independent dephosphorylation of phosphatidic acid (PA) lysophosphatidic acid and diacylglycerol pyrophosphate involved in control of the cellular levels of phosphatidylinositol and PA ZYRO0F17314g similar to uniprot|P14306 Saccharomyces cerevisiae YLR178C TFS1 Carboxypeptidase Y inhibitor (putative) lipid binding protein supressor of a cdc25 mutation ZYRO0F17336g weakly similar to Saccharomyces cerevisiae YLR177W Hypothetical ORF and to YDR505C uniprot|P50896 Saccharomyces cerevisiae YDR505C PSP1 Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition ZYRO0F17358g similar to uniprot|Q04399 Saccharomyces cerevisiae YDR506C Hypothetical ORF ZYRO0F17402g similar to uniprot|Q12263 Saccharomyces cerevisiae YDR507C ZYRO0F17424g highly similar to uniprot|Q12306 Saccharomyces cerevisiae YDR510W ZYRO0F17446g similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids ZYRO0F17468g highly similar to uniprot|Q96VH4 Saccharomyces cerevisiae YCL026C-B Hypothetical ORF ZYRO0F17490g weakly similar to uniprot|P11710 Saccharomyces cerevisiae YCL027W FUS1 Membrane protein localized to the shmoo tip required for cell fusion expression regulated by mating pheromone proposed to coordinate signaling fusion and polarization events required for fusion potential Cdc28p substrate ZYRO0F17512g some similarities with uniprot|P36110 Saccharomyces cerevisiae YKR013W PRY2 Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins ZYRO0F17534g some similarities with uniprot|Q8TFP8 Saccharomyces cerevisiae YCL028W RNQ1 [PIN(+)] prion an infectious protein conformation that is generally an ordered protein aggregate ZYRO0F17556g some similarities with uniprot|P11709 Saccharomyces cerevisiae YCL029C BIK1 Microtubule-associated protein component of the interface between microtubules and kinetochore involved in sister chromatid separation essential in polyploid cells but not in haploid or diploid cells ortholog of mammalian CLIP-170 ZYRO0F17578g highly similar to uniprot|P00815 Saccharomyces cerevisiae YCL030C ZYRO0F17600g similar to uniprot|Q02562 Saccharomyces cerevisiae YDR511W ACN9 Protein of the mitochondrial intermembrane space required for acetate utilization and gluconeogenesis has orthologs in higher eukaryotes ZYRO0F17622g similar to uniprot|P25368 Saccharomyces cerevisiae YCL031C RRP7 involved in rRNA processing ZYRO0F17644g similar to uniprot|P25344 Saccharomyces cerevisiae YCL032W STE50 Protein involved in mating response invasive/filamentous growth and osmotolerance acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction ZYRO0F17666g some similarities with uniprot|Q04406 Saccharomyces cerevisiae YDR512C EMI1 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1 also required for sporulation ZYRO0F17688g similar to uniprot|P25566 Saccharomyces cerevisiae YCL033C Hypothetical ORF ZYRO0F17710g similar to uniprot|P25369 Saccharomyces cerevisiae YCL034W LSB5 Protein of unknown function binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization ZYRO0F17732g similar to uniprot|P17695 Saccharomyces cerevisiae YDR513W TTR1 Glutaredoxin (thioltransferase) (glutathione reductase)and similar to uniprot|P25373 Saccharomyces cerevisiae YCL035c ZYRO0F17754g conserved hypothetical protein ZYRO0F17776g similar to uniprot|P25370 Saccharomyces cerevisiae YDR514C Hypothetical ORF and similar to YCL036w ZYRO0F17798g some similarities with uniprot|P25567 Saccharomyces cerevisiae YCL037C SRO9 Associates with translating ribosomes may function in the cytoplasm to modulate mRNA translation may be involved in organization of actin filaments RNA binding protein with La motif ZYRO0F17820g similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole ZYRO0F17842g similar to uniprot|P25569 Saccharomyces cerevisiae YCL039W ZYRO0F17864g highly similar to uniprot|P17709 Saccharomyces cerevisiae YCL040W GLK1 Glucokinase catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism one of three glucose phosphorylating enzymes expression regulated by non-fermentable carbon sources ZYRO0F17886g similar to uniprot|Q04410 Saccharomyces cerevisiae YDR517W GRH1 Golgi localized protein component of the spindle assembly checkpoint homolog of human GRASP65 which functions in postmitotic reassembly of Golgi stacks ZYRO0F17908g similar to uniprot|P17967 Saccharomyces cerevisiae YCL043C PDI1 Protein disulfide isomerase and similar to uniprot|P32474 Saccharomyces cerevisiae YDR518w ZYRO0F17930g similar to uniprot|P25573 Saccharomyces cerevisiae YCL044C ZYRO0F17952g similar to uniprot|P25574 Saccharomyces cerevisiae YCL045C ZYRO0F17974g similar to uniprot|P32472 Saccharomyces cerevisiae YDR519W FPR2 Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin expression pattern suggests possible involvement in ER protein trafficking ZYRO0F17996g similar to uniprot|P25576 Saccharomyces cerevisiae YCL047C Hypothetical ORF ZYRO0F18018g similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C Hypothetical ORF ZYRO0F18040g similar to uniprot|P25380 Saccharomyces cerevisiae YCL048W SPS22 Protein of unknown function redundant with Sps2p for the organization of the beta-glucan layer of the spore wall and similar to YDR522c uniprot|P08459 Saccharomyces cerevisiae and weakly similar to YBR078w uniprot|P38248 Saccharomyces cerevisiae and weakly similar to YDR055w uniprot|Q12355 Saccharomyces cerevisiae ZYRO0F18062g similar to uniprot|P08458 Saccharomyces cerevisiae YDR523C SPS1 dispensable for mitosis involved in middle/late stage of meiosis required for spore wall formation serine/threonine kinase homologous to Ste20p expressed in middle/late meiosis ZYRO0F18084g weakly similar to uniprot|Q04412 Saccharomyces cerevisiae YDR524C AGE1 ZYRO0F18106g some similarities with uniprot|Q3E6R4 Saccharomyces cerevisiae YDR524C-B ZYRO0F18128g similar to uniprot|P32460 Saccharomyces cerevisiae YIR030C DCG1 Protein of unknown function expression is sensitive to nitrogen catabolite repression and regulated by Dal80p contains transmembrane domain ZYRO0F18150g similar to uniprot|Q04418 Saccharomyces cerevisiae YDR527W ZYRO0F18172g weakly similar to uniprot|Q6Q537 Saccharomyces cerevisiae YDR532C Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles forms a complex with Spc105p ZYRO0F18194g similar to uniprot|Q04430 Saccharomyces cerevisiae YDR531W Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase EC 2.7.1.33) catalyzes the first committed step in the universal biosynthetic pathway leading to CoA. ZYRO0F18216g similar to uniprot|P16550 Saccharomyces cerevisiae YCL050C and similar to uniprot|P16550 Saccharomyces cerevisiae YDR530c ZYRO0F18238g highly similar to uniprot|P00128 Saccharomyces cerevisiae YDR529C ZYRO0F18260g weakly similar to uniprot|P25579 Saccharomyces cerevisiae YCL051W LRE1 Protein involved in control of cell wall structure and stress response inhibits Cbk1p protein kinase activity overproduction confers resistance to cell-wall degrading enzymes ZYRO0F18282g similar to uniprot|P25580 Saccharomyces cerevisiae YCL052C PBN1 Essential component of glycosylphosphatidylinositol-mannosyltransferase I required for the autocatalytic post-translational processing of the protease B precursor Prb1p localizes to ER in lumenal orientation homolog of mammalian PIG-X ZYRO0F18304g similar to uniprot|P25582 Saccharomyces cerevisiae YCL054W SPB1 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation methylates G2922 in the putative tRNA docking site of the large subunit rRNA and in the absence of snR52 U2921 suppressor of PAB1 mutants ZYRO0F18326g highly similar to uniprot|P25583 Saccharomyces cerevisiae YCL055W KAR4 Transcription factor required for induction of KAR3 and CIK1 during mating also required during meiosis exists in two forms a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone ZYRO0F18348g conserved hypothetical protein ZYRO0F18370g conserved hypothetical protein ZYRO0F18392g similar to uniprot|P25375 Saccharomyces cerevisiae YCL057W PRD1 Zinc metalloendopeptidase found in the cytoplasm and intermembrane space of mitochondria ZYRO0F18414g similar to uniprot|Q96VH5 Saccharomyces cerevisiae YCL057C-A ZYRO0F18436g similar to uniprot|Q2V2Q1 Saccharomyces cerevisiae YCL058W-A ZYRO0F18458g highly similar to uniprot|P25586 Saccharomyces cerevisiae YCL059C KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit ZYRO0F18480g weakly similar to uniprot|P25588 Saccharomyces cerevisiae YCL061C MRC1 S-phase checkpoint protein found at replication forks required for DNA replication also required for Rad53p activation during DNA replication stress where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p protein involved in replication checkpoint ZYRO0F18502g similar to uniprot|P25591 Saccharomyces cerevisiae YCL063W VAC17 vacuole inheritance ZYRO0F18524g similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase ZYRO0F18546g no similarity ZYRO0F18568g similar to uniprot|Q6B2C0 Saccharomyces cerevisiae YCR039C MATALPHA2 Homeobox-domain containing protein which in haploid cells acts with Mcm1p to repress a-specific genes in diploid cells Alpha2p acts together with A1p to repress transcription of haploid-specific genes ZYRO0F18590g similar to uniprot|P01365 Saccharomyces cerevisiae YCR040W MATALPHA1 Transcriptional co-activator involved in regulation of mating-type-specific gene expression targets the transcription factor Mcm1p to the promoters of alpha-specific genes one of two genes encoded by the alpha mating type cassette ZYRO0F18634g highly similar to uniprot|Q2UD26 Aspergillus oryzae AO090012000349 Choline dehydrogenase and related flavoproteins ZYRO0F18656g similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W and similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C ZYRO0F18678g similar to uniprot|P40988 Saccharomyces cerevisiae YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane ZYRO0F18700g weakly similar to uniprot|P53053 Saccharomyces cerevisiae YGL263W COS12 Protein of unknown function member of a family of conserved often subtelomerically- encoded proteins ZYRO0F18722g some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments ZYRO0G00132g some similarities with uniprot|P36034 Saccharomyces cerevisiae YKL219W COS9 ZYRO0G00154g no similarity ZYRO0G00176g similar to uniprot|P43543 Saccharomyces cerevisiae YNL335W Hypothetical ORF ZYRO0G00198g some similarities with uniprot|Q03034 Saccharomyces cerevisiae YDR539W Hypothetical ORF ZYRO0G00242g similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W ZYRO0G00286g highly similar to uniprot|P39003 Saccharomyces cerevisiae YDR343C HXT6 High-affinity glucose transporter of the major facilitator superfamily nearly identical to Hxt7p expressed at high basal levels relative to other HXTs repression of expression by high glucose requires SNF3 ZYRO0G00308g similar to gnl|GLV|KLLA0C18953g Kluyveromyces lactis KLLA0C18953g and some similarites with YKL015W uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type ZYRO0G00330g highly similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF ZYRO0G00352g weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W ZYRO0G00374g conserved hypothetical protein ZYRO0G00396g highly similar to uniprot|P38891 Saccharomyces cerevisiae YHR208W BAT1 Mitochondrial branched-chain amino acid aminotransferase homolog of murine ECA39 highly expressed during logarithmic phase and repressed during stationary phase ZYRO0G00418g similar to uniprot|P40099 Saccharomyces cerevisiae YER183C FAU1 5 10-methenyltetrahydrofolate synthetase involved in folic acid biosynthesis ZYRO0G00440g similar to uniprot|P40098 Saccharomyces cerevisiae YER182W FMP10 The authentic non-tagged protein was localized to the mitochondria ZYRO0G00462g similar to uniprot|P38890 Saccharomyces cerevisiae YHR207C SET5 ZYRO0G00484g similar to uniprot|P38889 Saccharomyces cerevisiae YHR206W ZYRO0G00506g similar to uniprot|P11792 Saccharomyces cerevisiae YHR205W SCH9 protein kinase involved in growth control may be redundant with cAMP pathway cAMP-dependent protein kinase homolog suppressor of cdc25ts ZYRO0G00528g similar to uniprot|P38888 Saccharomyces cerevisiae YHR204W MNL1 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides ZYRO0G00550g highly similar to uniprot|P05753 Saccharomyces cerevisiae YJR145C RPS4A or to YHR203C uniprot|P05753 Saccharomyces cerevisiae YHR203C RPS4B ZYRO0G00572g similar to uniprot|P38887 Saccharomyces cerevisiae YHR202W Hypothetical ORF ZYRO0G00616g highly similar to uniprot|Q00684 Saccharomyces cerevisiae YFR028C CDC14 Protein phosphatase required for mitotic exit located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit ZYRO0G00638g similar to uniprot|P43605 Saccharomyces cerevisiae YFR027W ECO1 Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication but not for its maintenance during G2 and M phases also required for postreplicative double-strand break repair interacts with Chl1p ZYRO0G00682g similar to uniprot|P38635 Saccharomyces cerevisiae YFR025C HIS2 Histidinolphosphatase catalyzes the eighth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control ZYRO0G00704g highly similar to uniprot|P38708 Saccharomyces cerevisiae YHR020W Protein required for cell viability ZYRO0G00726g similar to uniprot|P38707 Saccharomyces cerevisiae YHR019C DED81 Cytosolic asparaginyl-tRNA synthetase required for protein synthesis catalyzes the specific attachment of asparagine to its cognate tRNA ZYRO0G00748g highly similar to uniprot|P04076 Saccharomyces cerevisiae YHR018C ARG4 Argininosuccinate lyase catalyzes the final step in the arginine biosynthesis pathway ZYRO0G00770g similar to uniprot|P32792 Saccharomyces cerevisiae YHR017W ZYRO0G00792g similar to Saccharomyces cerevisiae YFR024C-A LSB3 or to YHR016C uniprot|P32793 Saccharomyces cerevisiae YHR016C YSC84 ZYRO0G00814g similar to uniprot|P39684 Saccharomyces cerevisiae or to YHR015W uniprot|P38760 Saccharomyces cerevisiae ZYRO0G00836g similar to uniprot|P40215 Saccharomyces cerevisiae YMR145C NDE1 Mitochondrial external NADH dehydrogenase ZYRO0G00902g similar to uniprot|Q75BF8 Ashbya gossypii ADL396W ADL396Wp and weakly similar to YNL246W uniprot|P53853 Saccharomyces cerevisiae YNL246W VPS75 ZYRO0G00924g similar to uniprot|Q759V0 Ashbya gossypii ADR172C ADR172Cp and weakly similar to YOR018W uniprot|Q02805 Saccharomyces cerevisiae YOR018W ROD1 Membrane protein overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium contains a PY-motif which is required for Rod1p interaction with Rsp5p a hect-type ubiquitin ligase ZYRO0G00946g similar to uniprot|P43601 Saccharomyces cerevisiae YFR021W ATG18 Phosphatidylinositol 3 5-bisphosphate-binding protein of the vacuolar membrane predicted to fold as a seven-bladed beta-propeller required for recycling of Atg9p through the pre-autophagosomal structure ZYRO0G00990g similar to uniprot|P34756 Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase vacuolar membrane kinase that generates phosphatidylinositol (3 5)P2 which is involved in vacuolar sorting and homeostasis ZYRO0G01012g similar to uniprot|P43599 Saccharomyces cerevisiae YFR018C Hypothetical ORF ZYRO0G01034g some similarities with uniprot|Q92325 Saccharomyces cerevisiae YOL025W LAG2 affects longevity involved in determination of longevity ZYRO0G01056g no similarity ZYRO0G01078g similar to uniprot|P25038 Saccharomyces cerevisiae YOL023W IFM1 Mitochondrial translation initiation factor 2 ZYRO0G01100g similar to uniprot|P25040 Saccharomyces cerevisiae YOL022C Protein required for cell viability ZYRO0G01144g highly similar to uniprot|P43535 Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn1p proposed to stimulate Gcn2p activation by an uncharged tRNA ZYRO0G01166g highly similar to uniprot|Q08162 Saccharomyces cerevisiae YOL021C DIS3 Nucleolar exosome component involved in rRNA processing and RNA degradation binds Gsp1p/Ran and enhances the GEF activity of Srm1p implicated in mitotic control homologous to the E. coli RNase R of the RNase II family ZYRO0G01188g highly similar to uniprot|P43593 Saccharomyces cerevisiae YFR010W UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome releases free ubiquitin from branched polyubiquitin chains deletion causes hypersensitivity to cycloheximide and other toxic compounds ZYRO0G01210g similar to uniprot|P43594 Saccharomyces cerevisiae YFR011C Hypothetical ORF ZYRO0G01276g similar to uniprot|Q03677 Saccharomyces cerevisiae YMR009W ADI1 Predicted acireductone dioxygenease of the methionine salvage pathway ZYRO0G01298g similar to uniprot|Q03687 YMR010W Saccharomyces cerevisiae Protein of unknown function ZYRO0G01320g weakly similar to uniprot|P32606 YOR017W Saccharomyces cerevisiae PET127 Protein with a role in mitochondrial RNA stability and/or processing ZYRO0G01342g similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C FMP12 The authentic non-tagged protein was localized to the mitochondria ZYRO0G01364g similar to uniprot|P23179 Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction required for homologous chromosome pairing and synaptonemal complex formation ZYRO0G01386g similar to uniprot|Q12450 Saccharomyces cerevisiae or to uniprot|P39704 Saccharomyces cerevisiae YAL007C ERP2 Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles ZYRO0G01408g weakly similar to uniprot|P18411 Saccharomyces cerevisiae YAL008W ZYRO0G01430g similar to uniprot|P38903 Saccharomyces cerevisiae YOR014W RTS1 B-type regulatory subunit of protein phosphatase 2A (PP2A) ZYRO0G01452g similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Hypothetical ORF ZYRO0G01474g similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane ZYRO0G01518g similar to uniprot|P18410 Saccharomyces cerevisiae YAL009W SPO7 Integral nuclear/ER membrane protein of unknown function required for normal nuclear envelope morphology and sporulation ZYRO0G01540g similar to uniprot|P18409 Saccharomyces cerevisiae YAL010C MDM10 Subunit of the mitochondrial sorting and assembly machinery (SAM complex) has a role in assembly of the TOM complex which mediates protein import through the outer membrane required for normal mitochondrial morphology and inheritance ZYRO0G01562g some similarities with uniprot|P31376 Saccharomyces cerevisiae YAL011W SWC3 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for formation of nuclear- associated array of smooth endoplasmic reticulum known as karmellae ZYRO0G01584g similar to uniprot|Q08204 Saccharomyces cerevisiae YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein interacts with Rhc18p and Nse1p to form a large complex S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair ZYRO0G01606g similar to uniprot|Q01476 Saccharomyces cerevisiae YOR124C UBP2 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins cleaves at the C terminus of ubiquitin fusions capable of cleaving polyubiquitin and possesses isopeptidase activity ZYRO0G01628g highly similar to uniprot|Q06389 Saccharomyces cerevisiae YDR373W FRQ1 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p member of the recoverin/frequenin branch of the EF-hand superfamily ZYRO0G01650g highly similar to uniprot|P41735 Saccharomyces cerevisiae YOR125C CAT5 Mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis essential for several other metabolic pathways including respiration and gluconeogenic gene activation ZYRO0G01672g some similarities with uniprot|Q06390 Saccharomyces cerevisiae YDR374C Hypothetical ORF ZYRO0G01694g similar to uniprot|Q2V2P8 Saccharomyces cerevisiae YDR374W-A ZYRO0G01716g highly similar to uniprot|P32839 Saccharomyces cerevisiae YDR375C BCS1 Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone required for the assembly of the cytochrome bc(1) complex from the Rip1p and Qcr10p proteins member of the CDC48/PAS1/SEC18 ATPase family ZYRO0G01738g similar to uniprot|P41734 Saccharomyces cerevisiae YOR126C IAH1 Isoamyl acetate-hydrolyzing esterase required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate which is particularly important in sake brewing ZYRO0G01760g similar to uniprot|P48360 Saccharomyces cerevisiae YDR376W ARH1 Oxidoreductase of the mitochondrial inner membrane involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes one of the few mitochondrial proteins essential for viability ZYRO0G01782g highly similar to uniprot|Q06405 Saccharomyces cerevisiae YDR377W ATP17 Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis ZYRO0G01804g some similarities with uniprot|Q06406 Saccharomyces cerevisiae YDR378C LSM6 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay ZYRO0G01826g similar to gnl|GLV|KLLA0B13794g Kluyveromyces lactis KLLA0B13794g gi|28565040|gb|AAO32603.1 Kluyveromyces lactis MNN4 hypothetical start KLLA0B13794g|KLLA-IPF6938|KLLA-CDS0444.1 and weakly similar to YKL201C uniprot|P36044 Saccharomyces cerevisiae YKL201C MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p) involved in mannosylphosphorylation of N-linked oligosaccharides expression increases in late-logarithmic and stationary growth phases ZYRO0G01848g similar to uniprot|P40354 Saccharomyces cerevisiae YJR062C NTA1 Amidase removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation ZYRO0G01870g no similarity ZYRO0G01892g highly similar to uniprot|P32529 Saccharomyces cerevisiae YJR063W RPA12 RNA polymerase I subunit A12.2 contains two zinc binding domains and the N terminal domain is responsible for anchoring to the RNA pol I complex ZYRO0G01914g highly similar to uniprot|P40413 Saccharomyces cerevisiae YJR064W CCT5 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo ZYRO0G01936g highly similar to uniprot|P47117 Saccharomyces cerevisiae YJR065C ARP3 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity ZYRO0G01958g highly similar to uniprot|P32600 Saccharomyces cerevisiae YKL203C TOR2 putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation distribution of the actin cytoskeleton and meiosis phosphatidylinositol kinase homolg ZYRO0G01980g similar to uniprot|P47118 Saccharomyces cerevisiae YJR067C YAE1 Essential protein of unknown function ZYRO0G02002g highly similar to uniprot|P40348 Saccharomyces cerevisiae YJR068W RFC2 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon ZYRO0G02024g weakly similar to uniprot|P36041 Saccharomyces cerevisiae YKL204W EAP1 eIF4E-associated protein binds eIF4E and inhibits cap-dependent translation also functions independently of eIF4E to maintain genetic stability plays a role in cell growth implicated in the TOR signaling cascade ZYRO0G02046g similar to uniprot|P33418 Saccharomyces cerevisiae YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA ZYRO0G02068g highly similar to uniprot|P47119 Saccharomyces cerevisiae YJR069C HAM1 Protein of unknown function that is involved in DNA repair mutant is sensitive to the base analog 6-N-hydroxylaminopurine while gene disruption does not increase the rate of spontaneous mutagenesis ZYRO0G02090g highly similar to uniprot|P47120 Saccharomyces cerevisiae YJR070C LIA1 Protein that binds to the C-terminal domain of Hyp2p (eIF5A) has four to five HEAT-like repeats ZYRO0G02112g similar to uniprot|P36040 Saccharomyces cerevisiae YKL206C Hypothetical ORF ZYRO0G02134g highly similar to uniprot|P47122 Saccharomyces cerevisiae YJR072C NPA3 Cytoplasmic protein required for cell viability identified by association with pre-ribosomal particles ZYRO0G02156g similar to uniprot|P36039 Saccharomyces cerevisiae YKL207W Hypothetical ORF ZYRO0G02178g weakly similar to uniprot|P36038 Saccharomyces cerevisiae YKL208W CBT1 Subunit of complex involved in processing of the 3' end of cytochrome b pre-mRNA involved in RNA splicing ZYRO0G02222g similar to uniprot|P05375 Saccharomyces cerevisiae YJR073C OPI3 Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase) catalyzes the last two steps in phosphatidylcholine biosynthesis ZYRO0G02244g similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells ZYRO0G02266g highly similar to uniprot|P22515 Saccharomyces cerevisiae YKL210W UBA1 Ubiquitin activating enzyme involved in ubiquitin-mediated protein degradation and essential for viability ZYRO0G02288g similar to uniprot|P47123 Saccharomyces cerevisiae YJR074W MOG1 Conserved nuclear protein that interacts with GTP-Gsp1p which is a Ran homolog of the Ras GTPase family and stimulates nucleotide release involved in nuclear protein import nucleotide release is inhibited by Yrb1p ZYRO0G02310g similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1 6-mannosyltransferase involved in cell wall mannan biosynthesis subunit of a Golgi-localized complex that also contains Anp1p Mnn9p Mnn11p and Mnn10p identified as a suppressor of a cell lysis sensitive pkc1-371 allele ZYRO0G02354g highly similar to uniprot|P32458 Saccharomyces cerevisiae YJR076C CDC11 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM ZYRO0G02376g highly similar to uniprot|P00937 Saccharomyces cerevisiae YKL211C TRP3 anthranilate synthase Component II and indole-3-phosphate (multifunctional enzyme) ZYRO0G02398g similar to uniprot|P32368 Saccharomyces cerevisiae YKL212W SAC1 Lipid phosphoinositide phosphatase of the ER and Golgi involved in protein trafficking and secretion ZYRO0G02420g similar to uniprot|P36037 Saccharomyces cerevisiae YKL213C DOA1 WD repeat protein required for ubiquitin-mediated protein degradation forms complex with Cdc48p plays a role in controlling cellular ubiquitin concentration also promotes efficient NHEJ in postdiauxic/stationary phase ZYRO0G02442g some similarities with uniprot|P36036 Saccharomyces cerevisiae YKL214C YRA2 Member of the REF (RNA and export factor binding proteins) family when overexpressed can substitute for the function of Yra1p in export of poly(A) mRNA from the nucleus ZYRO0G02486g similar to uniprot|Q0P727 Saccharomyces paradoxus HDF2 HDF2 protein ZYRO0G02508g highly similar to uniprot|P37012 Saccharomyces cerevisiae YMR105C PGM2 Phosphoglucomutase catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate which is a key step in hexose metabolism functions as the acceptor for a Glc-phosphotransferase and to YKL127W uniprot|P33401 Saccharomyces cerevisiae YKL127W PGM1 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6- phosphate, which is a key step in hexose metabolism ZYRO0G02530g highly similar to uniprot|P12688 Saccharomyces cerevisiae YKL126W and highly similar to uniprot|P18961 Saccharomyces cerevisiae YMR104C ZYRO0G02552g some similarities with uniprot|P36070 Saccharomyces cerevisiae YKL125W RRN3 Required for transcription of rDNA by RNA Polymerase I DNA-independent RNA Polymerase I transcription factor ZYRO0G02574g similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Suppressor of SHR3 confers leflunomide resistance when overexpressed (putative) involved in ER functions ZYRO0G02596g similar to uniprot|P32342 Saccharomyces cerevisiae YKL122C SRP21 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane ZYRO0G02618g similar to uniprot|Q03177 Saccharomyces cerevisiae YMR102C Protein of unknown function transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance ZYRO0G02640g similar to uniprot|P32332 Saccharomyces cerevisiae YKL120W OAC1 Mitochondrial inner membrane transporter transports oxaloacetate sulfate and thiosulfate member of the mitochondrial carrier family ZYRO0G02662g similar to uniprot|Q03175 Saccharomyces cerevisiae YMR101C SRT1 Cis-prenyltransferase involved in dolichol synthesis ZYRO0G02684g similar to uniprot|P32341 Saccharomyces cerevisiae YKL119C VPH2 Protein involved in vacuolar H -ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex ZYRO0G02706g similar to uniprot|Q03162 Saccharomyces cerevisiae YMR100W ZYRO0G02750g similar to uniprot|Q82BJ9 Streptomyces avermitilis SAV5706 Hypothetical protein ZYRO0G02772g similar to uniprot|P28707 Saccharomyces cerevisiae YKL117W ZYRO0G02794g highly similar to uniprot|Q03161 Saccharomyces cerevisiae YMR099C ORF ZYRO0G02816g similar to uniprot|P28708 Saccharomyces cerevisiae YKL116C PRR1 Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway ZYRO0G02838g highly similar to uniprot|P22936 Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents controls spontaneous mutations ZYRO0G02860g highly similar to uniprot|P26793 Saccharomyces cerevisiae YKL113C RAD27 5' to 3' exonuclease 5' flap endonuclease required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair member of the S. pombe RAD2/FEN1 family ZYRO0G02904g similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. ZYRO0G02926g some similarities with uniprot|P14164 Saccharomyces cerevisiae YKL112W ABF1 DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation gene silencing and DNA replication and repair ZYRO0G02948g similar to uniprot|Q03153 Saccharomyces cerevisiae YMR098C Hypothetical ORF ZYRO0G02970g similar to uniprot|P34253 Saccharomyces cerevisiae YKL110C KTI12 Protein associated with the RNA polymerase II Elongator complex involved in sensitivity to G1 arrest induced by Kluyveromyces lactis toxin zymocin ZYRO0G02992g similar to uniprot|Q03151 Saccharomyces cerevisiae YMR097C MTG1 Peripheral GTPase of the mitochondrial inner membrane essential for respiratory competence likely functions in assembly of the large ribosomal subunit has homologs in plants and animals ZYRO0G03014g weakly similar to uniprot|P41902 Saccharomyces cerevisiae YOR031W CRS5 Copper-binding metallothionein required for wild-type copper resistance ZYRO0G03036g conserved hypothetical protein ZYRO0G03058g highly similar to uniprot|P43545 Saccharomyces cerevisiae YFL059W SNZ3 Member of a stationary phase-induced gene family transcription of SNZ2 is induced prior to diauxic shift and also in the absence of thiamin in a Thi2p-dependent manner forms a coregulated gene pair with SNO3 and uniprot|P53824 Saccharomyces cerevisiae YNL333W SNZ2 and YMR096W uniprot|Q03148 Saccharomyces cerevisiae YMR096W SNZ1 ZYRO0G03080g similar to uniprot|P43544 Saccharomyces cerevisiae YFL060C SNO3 Protein of unknown function nearly identical to Sno2p expression is induced before the diauxic shift and also in the absence of thiamin and uniprot|P53823 Saccharomyces cerevisiae YNL334C SNO2 and uniprot|Q03144 Saccharomyces cerevisiae YMR095C SNO1 ZYRO0G03102g similar to uniprot|P35203 Saccharomyces cerevisiae YMR094W CTF13 Subunit of the CBF3 complex which binds to the CDE III element of centromeres bending the DNA upon binding and may be involved in sister chromatid cohesion during mitosis ZYRO0G03124g similar to uniprot|Q75DR2 Ashbya gossypii ABL045W ABL045Wp and weakly similar to YKL108W uniprot|P34252 Saccharomyces cerevisiae YKL108W SLD2 Protein required for DNA replication phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks) phosphorylation is essential for DNA replication and for complex formation with Dpb11p potential Cdc28p substrate ZYRO0G03146g highly similar to uniprot|Q04305 Saccharomyces cerevisiae YMR093W UTP15 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0G03168g similar to uniprot|P46680 Saccharomyces cerevisiae YMR092C AIP1 Actin cortical patch component probable binding site on actin lies on front surface of subdomains 3 and 4 ZYRO0G03190g similar to uniprot|P32832 Saccharomyces cerevisiae YMR091C NPL6 Nuclear protein that may have a role in nuclear protein import ZYRO0G03212g similar to uniprot|P40341 Saccharomyces cerevisiae YMR089C YTA12 Component with Afg3p of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes ZYRO0G03234g similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane ZYRO0G03256g similar to uniprot|Q04299 Saccharomyces cerevisiae YMR087W Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose may have a role in tRNA splicing contains an A1pp domain ZYRO0G03278g similar to uniprot|Q01802 Saccharomyces cerevisiae YKL106W AAT1 Mitochondrial aspartate aminotransferase catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis ZYRO0G03300g some similarities with uniprot|Q04279 Saccharomyces cerevisiae YMR086W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery ZYRO0G03322g highly similar to uniprot|P14742 Saccharomyces cerevisiae YKL104C GFA1 Glutamine-fructose-6-phosphate amidotransferase catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis ZYRO0G03344g similar to uniprot|P14904 YKL103C Saccharomyces cerevisiae LAP4 Vacuolar aminopeptidase ZYRO0G03366g similar to uniprot|P34244 Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints associates with the assembled septin filament required along with Hsl7p for bud neck recruitment phosphorylation and degradation of Swe1p ZYRO0G03388g similar to uniprot|P07246 Saccharomyces cerevisiae YMR083W ZYRO0G03410g similar to uniprot|P07246 Saccharomyces cerevisiae YMR083W ADH3 ZYRO0G03454g some similarities with uniprot|P32945 Saccharomyces cerevisiae YPL179W PPQ1 Putative protein serine/threonine phosphatase null mutation enhances efficiency of translational suppressors ZYRO0G03476g conserved hypothetical protein ZYRO0G03498g weakly similar to uniprot|Q6B1X3 Saccharomyces cerevisiae YPL181W CTI6 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter contains a PHD finger domain ZYRO0G03520g similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p family essential for vacuolar protein sorting required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p ZYRO0G03542g similar to uniprot|Q08921 Saccharomyces cerevisiae YPL180W TCO89 Tor Complex One ZYRO0G03564g similar to uniprot|P53010 Saccharomyces cerevisiae YGL094C PAN2 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes ZYRO0G03586g similar to uniprot|Q08924 Saccharomyces cerevisiae YPL183C Hypothetical ORF ZYRO0G03608g similar to uniprot|Q07843 Saccharomyces cerevisiae YLL033W ZYRO0G03630g similar to uniprot|Q07834 Saccharomyces cerevisiae YLL032C Hypothetical ORF ZYRO0G03696g similar to uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Protein of unknown function localizes to lipid particles ZYRO0G03718g no similarity ZYRO0G03740g similar to uniprot|P30771 Saccharomyces cerevisiae YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons ZYRO0G03762g similar to uniprot|P33314 Saccharomyces cerevisiae YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types ZYRO0G03784g highly similar to uniprot|P24280 Saccharomyces cerevisiae YMR079W SEC14 Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism products of which are regulators in Golgi to plasma membrane transport functionally homologous to mammalian PITPs ZYRO0G03806g similar to uniprot|P49956 Saccharomyces cerevisiae YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion may have overlapping functions with Rad24p in the DNA damage replication checkpoint ZYRO0G03828g similar to uniprot|Q04272 Saccharomyces cerevisiae YMR077C VPS20 vaculolar protein sorting (putative) ZYRO0G03850g similar to gnl|GLV|CAGL0J01936g Candida glabrata CAGL0J01936g and some similarites with uniprot|P40564 YIR004W Saccharomyces cerevisiae DJP1 Cytosolic J-domain-containing protein, required for peroxisomal protein import ZYRO0G03872g some similarities with uniprot|P40563 Saccharomyces cerevisiae YIR003W Hypothetical ORF ZYRO0G03894g highly similar to uniprot|P33331 Saccharomyces cerevisiae YER009W NTF2 Nuclear envelope protein interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport ZYRO0G03916g weakly similar to uniprot|P33332 YER008C Saccharomyces cerevisiae SEC3 Non-essential subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p Exo84p) ZYRO0G03938g similar to uniprot|P40562 YIR002C Saccharomyces cerevisiae MPH1 Member of the DEAH family of helicases ZYRO0G03982g some similarities with uniprot|P32521 YIR006C Saccharomyces cerevisiae PAN1 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p ZYRO0G04004g similar to uniprot|P40565 YIR005W Saccharomyces cerevisiae IST3 Component of the U2 snRNP required for the first catalytic step of splicing and for spliceosomal assembly ZYRO0G04026g similar to uniprot|P40011 Saccharomyces cerevisiae YER010C Hypothetical ORF ZYRO0G04048g similar to uniprot|P40549 Saccharomyces cerevisiae YIL014W MNT3 Alpha-1 3-mannosyltransferase adds the fourth and fifth alpha-1 3-linked mannose residues to O-linked glycans during protein O-glycosylation ZYRO0G04092g weakly similar to uniprot|P40573 Saccharomyces cerevisiae YIR017C MET28 Transcriptional activator in the Cbf1p-Met4p-Met28p complex participates in the regulation of sulfur metabolism ZYRO0G04114g some similarities with uniprot|Q08206 Saccharomyces cerevisiae YOL036W Protein of unknown function potential Cdc28p substrate ZYRO0G04136g highly similar to uniprot|P40303 Saccharomyces cerevisiae YOL038W PRE6 20S proteasome alpha-type subunit ZYRO0G04158g some similarities with uniprot|Q08176 Saccharomyces cerevisiae YOL026C MIM1 Mitochondrial outer membrane protein that mediates assembly of mitochondrial beta-barrel proteins also proposed to be involved in mitochondrial import ZYRO0G04180g similar to uniprot|P40571 Saccharomyces cerevisiae YIR015W RPR2 Subunit of nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends not shared between Rnase MRP and Rnase P in contrast to all other Rnase P protein subunits ZYRO0G04202g weakly similar to uniprot|P40570 Saccharomyces cerevisiae YIR014W Hypothetical ORF ZYRO0G04224g some similarites with uniprot|Q08179 Saccharomyces cerevisiae YOL027C MDM38 Mitochondrial Distribution and Morphology ZYRO0G04246g similar to uniprot|P40574 Saccharomyces cerevisiae YIR018W YAP5 bZIP transcription factor ZYRO0G04268g similar to uniprot|Q08193 Saccharomyces cerevisiae YOL030W GAS5 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall ZYRO0G04312g weakly similar to uniprot|Q08157 Saccharomyces cerevisiae YOL019W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole ZYRO0G04334g similar to uniprot|Q08144 Saccharomyces cerevisiae YOL018C TLG2 member of the syntaxin family of t-SNAREs ZYRO0G04356g weakly similar to uniprot|Q92274 Saccharomyces cerevisiae YOR129C Putative component of the outer plaque of the spindle pole body may be involved in cation homeostasis or multidrug resistance ZYRO0G04378g similar to uniprot|Q06408 Saccharomyces cerevisiae YDR380W ARO10 Phenylpyruvate decarboxylase catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde which is the first specific step in the Ehrlich pathway ZYRO0G04400g uniprot|Q9UVE6 Zygosaccharomyces rouxii ade2 Phosphoribosylaminoimidazole carboxylase ZYRO0G04422g highly similar to uniprot|Q3E785 Saccharomyces cerevisiae YDR379C-A Hypothetical ORF ZYRO0G04444g uniprot|Q9P8F2 Zygosaccharomyces rouxii rga1 Pheromone response protein ZYRO0G04466g some similarities with uniprot|P17106 Saccharomyces cerevisiae YJR060W CBF1 Helix-loop-helix protein that binds the motif CACRTG (R ZYRO0G04488g similar to uniprot|P47116 Saccharomyces cerevisiae YJR059W PTK2 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane enhances spermine uptake ZYRO0G04510g similar to uniprot|P24004 Saccharomyces cerevisiae YKL197C PEX1 AAA-family ATPase peroxin required for peroxisome biogenesis contains two 230 amino acid ATP-binding AAA cassettes upregulated in anaerobiosis Pex1p and Pex6p interact via their N-terminal AAA-cassettes ZYRO0G04532g highly similar to uniprot|Q00381 Saccharomyces cerevisiae YJR058C APS2 Small subunit of the clathrin-associated adaptor complex AP-2 which is involved in protein sorting at the plasma membrane related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex ZYRO0G04554g similar to uniprot|P00572 Saccharomyces cerevisiae YJR057W CDC8 Thymidylate and uridylate kinase functions in de novo biosynthesis of pyrimidine deoxyribonucleotides converts dTMP to dTDP and dUMP to dUTP essential for mitotic and meiotic DNA replication homologous to S. pombe Tmp1p ZYRO0G04598g no similarity ZYRO0G04620g similar to uniprot|P47115 Saccharomyces cerevisiae YJR056C Hypothetical ORF ZYRO0G04642g weakly similar to uniprot|P54003 Saccharomyces cerevisiae YML052W SUR7 ZYRO0G04664g similar to uniprot|P04387 Saccharomyces cerevisiae YML051W GAL80 Transcriptional regulator involved in the repression of GAL genes in the absence of galactose inhibits transcriptional activation by Gal4p inhibition relieved by Gal3p or Gal1p binding ZYRO0G04686g similar to uniprot|P46973 Saccharomyces cerevisiae YJR055W HIT1 Protein of unknown function required for growth at high temperature ZYRO0G04708g similar to uniprot|Q04689 Saccharomyces cerevisiae YML050W Hypothetical ORF ZYRO0G04730g similar to uniprot|Q04693 Saccharomyces cerevisiae YML049C RSE1 RNA splicing and ER to Golgi transport involved in secretion and RNA splicing ZYRO0G04752g similar to uniprot|Q04697 Saccharomyces cerevisiae YML048W GSF2 ER localized integral membrane protein that may promote secretion of certain hexose transporters including Gal2p involved in glucose-dependent repression ZYRO0G04796g some similarities with uniprot|P47114 Saccharomyces cerevisiae YJR054W Vacuolar protein of unknown function potential Cdc28p substrate ZYRO0G04818g similar to uniprot|P47113 Saccharomyces cerevisiae YJR053W BFA1 Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis ZYRO0G04840g similar to uniprot|P39682 Saccharomyces cerevisiae YML046W PRP39 U1 snRNP protein involved in splicing contains multiple tetriatricopeptide repeats ZYRO0G04862g highly similar to gnl|GLV|CAGL0J11154g Candida glabrata CAGL0J11154g and similar to YNL175C uniprot|P53883 Saccharomyces cerevisiae ZYRO0G04884g some similarities with uniprot|P38845 Saccharomyces cerevisiae YHR146W CRP1 Protein that binds to cruciform DNA structures ZYRO0G04928g similar to uniprot|P53886 Saccharomyces cerevisiae YNL172W APC1 Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition ZYRO0G04950g highly similar to uniprot|P39006 Saccharomyces cerevisiae YNL169C PSD1 Phosphatidylserine decarboxylase of the mitochondrial inner membrane converts phosphatidylserine to phosphatidylethanolamine ZYRO0G04972g similar to uniprot|P06773 Saccharomyces cerevisiae YHR144C DCD1 Deaminase required for dCTP and dTTP synthesis expression is cell cycle regulated ZYRO0G04994g highly similar to uniprot|P53889 Saccharomyces cerevisiae YNL168C FMP41 The authentic non-tagged protein was localized to mitochondria ZYRO0G05016g some similarities with uniprot|Q02100 Saccharomyces cerevisiae YNL167C SKO1 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family that forms a complex with Tup1p and Ssn6p to both activate and repress transcription cytosolic and nuclear protein involved in the osmotic and oxidative stress responses ZYRO0G05038g highly similar to uniprot|P40422 Saccharomyces cerevisiae YHR143W-A RPC10 RNA polymerase subunit ABC10-alpha common to RNA polymerases I II and III ZYRO0G05060g similar to uniprot|P53890 Saccharomyces cerevisiae YNL166C BNI5 Protein involved in organization of septins at the mother-bud neck may interact directly with the Cdc11p septin localizes to bud neck in a septin-dependent manner ZYRO0G05082g similar to uniprot|P53891 Saccharomyces cerevisiae YNL165W Hypothetical ORF ZYRO0G05104g some similarities with uniprot|P38844 Saccharomyces cerevisiae YHR143W ZYRO0G05126g some similarities with uniprot|P53892 Saccharomyces cerevisiae YNL164C IBD2 Component of the BUB2-dependent spindle checkpoint pathway interacts with Bfa1p and functions upstream of Bub2p and Bfa1p ZYRO0G05148g similar to uniprot|P53893 Saccharomyces cerevisiae YNL163C ZYRO0G05170g highly similar to uniprot|P38843 Saccharomyces cerevisiae YHR142W CHS7 ZYRO0G05192g highly similar to uniprot|P02405 Saccharomyces cerevisiae YHR141C RPL42B Proteins component of the large (60S) ribosomal subunit ZYRO0G05214g some similarities with uniprot|P53894 Saccharomyces cerevisiae YNL161W CBK1 Protein kinase involved in cell wall biosynthesis required for efficient apical growth proper mating projection morphology bipolar bud site selection in diploid cells and cell separation ZYRO0G05236g similar to uniprot|P38842 Saccharomyces cerevisiae YHR140W Hypothetical ORF ZYRO0G05258g weakly similar to uniprot|P38616 Saccharomyces cerevisiae YNL160W YGP1 may be involved in cellular adaptations prior to stationary phase YGP1 encodes gp37 a glycoprotein synthesized in response to nutrient limitation which is homologous to the sporulation-specific SPS100 gene ZYRO0G05280g similar to uniprot|P41948 Saccharomyces cerevisiae YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4) expression is under the nitrogen catabolite repression regulation ZYRO0G05302g similar to uniprot|P38841 Saccharomyces cerevisiae YHR138C Homologous to PBI2 ZYRO0G05324g highly similar to uniprot|P53900 Saccharomyces cerevisiae YNL153C GIM3 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it ZYRO0G05346g similar to uniprot|P38840 Saccharomyces cerevisiae YHR137W ARO9 Aromatic aminotransferase catalyzes the first step of tryptophan phenylalanine and tyrosine catabolism ZYRO0G05368g no similarity ZYRO0G05390g highly similar to uniprot|P53909 Saccharomyces cerevisiae YNL141W AAH1 Adenine deaminase (adenine aminohydrolase) involved in purine salvage and nitrogen catabolism ZYRO0G05412g similar to uniprot|P23292 Saccharomyces cerevisiae YNL154C YCK2 membrane-bound casein kinase I homolog ZYRO0G05434g similar to uniprot|P53899 Saccharomyces cerevisiae YNL155W Hypothetical ORF ZYRO0G05456g similar to uniprot|P38838 Saccharomyces cerevisiae YHR134W WSS1 weak suppressor of smt3 ZYRO0G05478g similar to uniprot|P53898 Saccharomyces cerevisiae YNL156C NSG2 Protein of unknown function potential homolog of mammalian Insig 1 ZYRO0G05500g highly similar to uniprot|Q9P305 Saccharomyces cerevisiae YHR132W-A Hypothetical ORF ZYRO0G05522g similar to uniprot|P38836 Saccharomyces cerevisiae YHR132C ZYRO0G05544g similar to uniprot|P53896 Saccharomyces cerevisiae YNL158W Essential protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery ZYRO0G05566g similar to uniprot|P53895 Saccharomyces cerevisiae YNL159C ASI2 Predicted membrane protein genetic interactions suggest a role in negative regulation of amino acid uptake ZYRO0G05610g some similarities with uniprot|P00812 Saccharomyces cerevisiae YPL111W ZYRO0G05632g similar to uniprot|P38835 Saccharomyces cerevisiae YHR131C Hypothetical ORF ZYRO0G05654g conserved hypothetical protein ZYRO0G05676g similar to uniprot|P38696 Saccharomyces cerevisiae YHR129C ARP1 Actin-related protein of the dynactin complex required for spindle orientation and nuclear migration putative ortholog of mammalian centractin ZYRO0G05698g highly similar to uniprot|P18562 Saccharomyces cerevisiae YHR128W FUR1 Uracil phosphoribosyltransferase synthesizes UMP from uracil involved in the pyrimidine salvage pathway ZYRO0G05720g highly similar to uniprot|P53905 Saccharomyces cerevisiae YNL147W LSM7 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay ZYRO0G05742g similar to uniprot|Q754L8 Ashbya gossypii AFR054W AFR054Wp and weakly similar to YNL148C uniprot|P53904 Saccharomyces cerevisiae YNL148C ALF1 alpha-tubulin foldin protein implicated in folding of alpha tubulin cofactor B ZYRO0G05764g similar to gnl|GLV|KLLA0A11506g Kluyveromyces lactis KLLA0A11506g and weakly similar to YNL149C uniprot|P53903 Saccharomyces cerevisiae YNL149C Protein required for cell viability ZYRO0G05786g similar to uniprot|P17890 Saccharomyces cerevisiae YNL151C RPC31 RNA polymerase III subunit C31 contains HMG-like C-terminal domain ZYRO0G05808g similar to uniprot|P53901 Saccharomyces cerevisiae YNL152W Protein required for cell viability ZYRO0G05830g similar to uniprot|P53552 Saccharomyces cerevisiae YNL139C RLR1 Required for LacZ RNA expression from certain plasmids suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) plays a role in transcription elongation by RNA polymerase II Involved in transcription ZYRO0G05852g similar to uniprot|P0C074 Saccharomyces cerevisiae YNL138W-A RCP10 Component of the U2 snRNP associated with the SF3b complex conserved in Ashbya gossypii ZYRO0G05874g similar to gnl|GLV|CAGL0H09086g Candida glabrata CAGL0H09086g and some similarites with YHR127W uniprot|P38833 Saccharomyces cerevisiae YHR127W (H)igh copy (S)uppressor of (N)34 dominant negative allele of SEC4. Suppression is very specific to this allele. It has no affect on the analogous YPT1 allele. No homology or known function. ZYRO0G05896g similar to uniprot|P17555 Saccharomyces cerevisiae YNL138W SRV2 Adenylyl cyclase-associated protein N-terminal domain appears to be involved in cellular responsiveness to RAS ZYRO0G05918g similar to uniprot|P27929 Saccharomyces cerevisiae YNL137C NAM9 Mitochondrial ribosomal component of the small subunit ZYRO0G05940g some similarities with uniprot|P53911 Saccharomyces cerevisiae YNL136W EAF7 Subunit of the NuA4 histone acetyltransferase complex which acetylates the N-terminal tails of histones H4 and H2A ZYRO0G05962g highly similar to uniprot|P20081 Saccharomyces cerevisiae YNL135C FPR1 Peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function ZYRO0G05984g similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C ZYRO0G06006g no similarity ZYRO0G06028g no similarity ZYRO0G06072g no similarity ZYRO0G06116g no similarity ZYRO0G06160g some similarities with uniprot|P38830 Saccharomyces cerevisiae YHR124W NDT80 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination activates middle sporulation genes competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) ZYRO0G06182g highly similar to uniprot|P53914 Saccharomyces cerevisiae YNL132W KRE33 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance ZYRO0G06204g similar to uniprot|P49334 Saccharomyces cerevisiae YNL131W TOM22 Translocase of Outer Mitochondrial membrane Mitochondrial import receptor complex protein ZYRO0G06226g similar to uniprot|P17898 Saccharomyces cerevisiae YNL130C CPT1 and similar to uniprot|P22140 Saccharomyces cerevisiae YHR123w Cholinephosphotransferase ZYRO0G06248g similar to uniprot|P38829 Saccharomyces cerevisiae YHR122W Protein required for cell viability ZYRO0G06270g similar to uniprot|P53915 Saccharomyces cerevisiae YNL129W ZYRO0G06292g uniprot|Q6RI82 Zygosaccharomyces rouxii TEP1 TEP1 protein ZYRO0G06314g uniprot|Q6RI83 Zygosaccharomyces rouxii similar to YHR121W uniprot|P38828 Saccharomyces cerevisiae YHR121W LSM12 Protein containing an Lsm domain and an AD domain may bind RNA and have a role in RNA processing ZYRO0G06336g similar to uniprot|P53917 Saccharomyces cerevisiae YNL127W FAR11 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far8p Far9p and Far10p ZYRO0G06358g similar to uniprot|P53540 Saccharomyces cerevisiae YNL126W SPC98 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque ZYRO0G06380g some similarities with uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases appears not to be involved in transport of monocarboxylates such as lactate pyruvate or acetate across the plasma membrane ZYRO0G06402g some similarities with uniprot|P53919 Saccharomyces cerevisiae YNL124W ZYRO0G06424g similar to uniprot|P25846 Saccharomyces cerevisiae YHR120W MSH1 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA has ATPase activity and binds to DNA mismatches has homology to E. coli MutS transcription is induced during meiosis ZYRO0G06446g similar to uniprot|P38827 Saccharomyces cerevisiae YHR119W SET1 Histone methyltransferase subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres contains a SET domain ZYRO0G06468g similar to uniprot|P38826 Saccharomyces cerevisiae YHR118C ORC6 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing may be phosphorylated by Cdc28p ZYRO0G06490g similar to uniprot|Q75D91 Ashbya gossypii ABR133W 50S ribosomal protein L35 and some similarites with YNL122C uniprot|P53921 Saccharomyces cerevisiae YNL122C Hypothetical ORF ZYRO0G06512g similar to uniprot|P07213 Saccharomyces cerevisiae YNL121C TOM70 Translocase of Outer Mitochondrial membrane 70 kDa mitochondrial specialized import receptor of the outer membrane ZYRO0G06534g similar to uniprot|P38824 Saccharomyces cerevisiae YHR116W COX23 Mitochondrial intermembrane space protein that functions in mitochondrial ZYRO0G06556g conserved hypothetical protein ZYRO0G06578g similar to uniprot|P32354 Saccharomyces cerevisiae YIL150C MCM10 Essential chromatin-associated protein involved in the initiation of DNA replication required for the association of the MCM2-7 complex with replication origins ZYRO0G06600g some similarities with uniprot|Q02455 Saccharomyces cerevisiae YKR095W MLP1 Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; involved in the retention of unspliced mRNAs in the nucleus ZYRO0G06622g highly similar to uniprot|P14796 Saccharomyces cerevisiae YKR094C RPL40B ZYRO0G06644g similar to uniprot|P39928 Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators ZYRO0G06666g similar to uniprot|P40458 Saccharomyces cerevisiae YIL146C ECM37 Non-essential protein of unknown function ZYRO0G06688g similar to uniprot|P32901 Saccharomyces cerevisiae YKR093W PTR2 Functions in transport of small peptides into the cell Peptide transporter ZYRO0G06710g conserved hypothetical protein ZYRO0G06732g similar to uniprot|P40459 Saccharomyces cerevisiae YIL145C PAN6 Pantothenate synthase also known as pantoate-beta-alanine ligase required for pantothenic acid biosynthesis deletion causes pantothenic acid auxotrophy homologous to E. coli panC ZYRO0G06754g highly similar to gnl|GLV|CAGL0G05291g Candida glabrata CAGL0G05291g and similar to YDR071C uniprot|Q12447 Saccharomyces cerevisiae YDR071C PAA1 Polyamine acetyltransferase acetylates polyamines such as putrescine spermidine and spermine may be involved in transcription initiation ZYRO0G06776g similar to uniprot|Q12497 Saccharomyces cerevisiae YDR070C FMP16 The authentic non-tagged protein was localized to the mitochondria ZYRO0G06798g some similarities with uniprot|P32571 Saccharomyces cerevisiae YDR069C DOA4 Ubiquitin hydrolase required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole ZYRO0G06820g similar to uniprot|P54858 Saccharomyces cerevisiae YDR068W DOS2 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm ZYRO0G06842g similar to uniprot|Q6Q559 Saccharomyces cerevisiae YDR067C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts ZYRO0G06864g similar to uniprot|P40087 Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein contains a ubiquitin-associated (UBA) domain may act as a negative regulator of constitutive exocytosis may play a role in S-phase checkpoint control ZYRO0G06886g similar to uniprot|P22134 Saccharomyces cerevisiae YER142C MAG1 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired ZYRO0G06908g similar to uniprot|P40086 Saccharomyces cerevisiae YER141W COX15 Protein required for the hydroxylation of heme O to form heme A which is an essential prosthetic group for cytochrome c oxidase ZYRO0G06930g similar to uniprot|P40085 Saccharomyces cerevisiae YER140W Hypothetical ORF ZYRO0G06952g similar to uniprot|P40084 Saccharomyces cerevisiae YER139C Hypothetical ORF ZYRO0G06974g similar to uniprot|Q6Q5U4 Saccharomyces cerevisiae YDR065W Hypothetical ORF ZYRO0G07018g similar to uniprot|P13856 Saccharomyces cerevisiae YGR152C RSR1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases ZYRO0G07040g similar to gnl|GLV|KLLA0C12023g Kluyveromyces lactis KLLA0C12023g and some similarites with YGL105W uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids ZYRO0G07084g conserved hypothetical protein ZYRO0G07106g highly similar to uniprot|P05373 Saccharomyces cerevisiae YGL040C HEM2 Delta-aminolevulinate dehydratase a homo-octameric enzyme catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen the second step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus ZYRO0G07128g highly similar to uniprot|P32582 Saccharomyces cerevisiae YGR155W CYS4 Cystathionine beta-synthase catalyzes the synthesis of cystathionine from serine and homocysteine the first committed step in cysteine biosynthesis ZYRO0G07150g similar to uniprot|P0C5N3 Saccharomyces cerevisiae YGL041W-A Identified by expression profiling and mass spectrometry ZYRO0G07172g conserved hypothetical protein ZYRO0G07194g highly similar to gnl|GLV|CAGL0D06160g Candida glabrata CAGL0D06160g and similar to uniprot|P07273 YGL043W Saccharomyces cerevisiae DST1 General transcription elongation factor TFIIS ZYRO0G07216g similar to uniprot|P25299 Saccharomyces cerevisiae YGL044C RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p ZYRO0G07238g some similarities with uniprot|P39927 Saccharomyces cerevisiae YGR156W PTI1 Pta1p Interacting protein ZYRO0G07260g similar to uniprot|P05374 Saccharomyces cerevisiae YGR157W CHO2 First step in the methylation pathway for phosphatidylcholine biosynthesis Phosphatidyl-ethanolamine N-methyltransferase ZYRO0G07282g similar to uniprot|P48240 Saccharomyces cerevisiae YGR158C MTR3 3'5' exoribonuclease exosome subunit nucleolar protein involved in export of mRNA and ribosomal subunits homologous to the E. coli exonuclease RNase PH ZYRO0G07304g similar to uniprot|P53180 Saccharomyces cerevisiae YGL045W RIM8 ZYRO0G07326g some similarities with uniprot|P27476 Saccharomyces cerevisiae YGR159C NSR1 Nucleolar protein that binds nuclear localization sequences required for pre-rRNA processing and ribosome biogenesis ZYRO0G07348g no similarity ZYRO0G07370g some similarities with uniprot|P53289 Saccharomyces cerevisiae YGR161C RTS3 Hypothetical ORF ZYRO0G07392g similar to uniprot|P53746 Saccharomyces cerevisiae YNR060W FRE4 Ferric reductase reduces a specific subset of siderophore-bound iron prior to uptake by transporters expression induced by low iron levels ZYRO0G07414g similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores ZYRO0G07436g conserved hypothetical protein ZYRO0G07458g conserved hypothetical protein ZYRO0G07480g conserved hypothetical protein ZYRO0G07502g similar to uniprot|P38732 Saccharomyces cerevisiae YHL039W Hypothetical ORF ZYRO0G07524g uniprot|Q9HF97 Zygosaccharomyces rouxii cof1 Cofilin ZYRO0G07546g weakly similar to uniprot|Q07887 Saccharomyces cerevisiae YLL049W ZYRO0G07568g weakly similar to uniprot|P03874 Saccharomyces cerevisiae YHL038C CBP2 Protein required for splicing of COB aI5 intron Cytochrome B pre-mRNA processing protein ZYRO0G07590g similar to uniprot|P38734 Saccharomyces cerevisiae YHL036W MUP3 Low affinity methionine permease, similar to Mup1p ZYRO0G07612g similar to uniprot|P32386 Saccharomyces cerevisiae YLL048C ZYRO0G07634g similar to uniprot|P10080 Saccharomyces cerevisiae YHL034C SBP1 Single-strand nucleic acid binding protein ZYRO0G07656g highly similar to uniprot|P29453 Saccharomyces cerevisiae RPL8B and to YHL033C uniprot|P17076 Saccharomyces cerevisiae RPL8A Ribosomal protein L4 of the large (60S) ribosomal subunit ZYRO0G07700g similar to uniprot|P32190 Saccharomyces cerevisiae YHL032C GUT1 Glycerol kinase converts glycerol to glycerol-3-phosphate glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p ZYRO0G07722g uniprot|Q6RW11 Zygosaccharomyces rouxii FPS1 Glycerol facilitator ZYRO0G07744g highly similar to uniprot|P38736 Saccharomyces cerevisiae YHL031C GOS1 v-SNARE protein involved in Golgi transport homolog of the mammalian protein GOS-28/GS28 ZYRO0G07766g similar to uniprot|Q07879 Saccharomyces cerevisiae YLL042C ATG10 Enzyme that mediates formation of the Atg12p-Atg5p conjugate which is a critical step in autophagy ZYRO0G07788g highly similar to uniprot|P21801 Saccharomyces cerevisiae YLL041C SDH2 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone ZYRO0G07810g similar to uniprot|Q07878 Saccharomyces cerevisiae YLL040C VPS13 homologous to human COH1 component of peripheral vacuolar membrane protein complex ZYRO0G07832g similar to uniprot|P38737 Saccharomyces cerevisiae YHL030W ECM29 Major component of the proteasome tethers the proteasome core particle to the regulatory particle and enhances the stability of the proteasome ZYRO0G07854g highly similar to uniprot|P04838 Saccharomyces cerevisiae YLL039c UBI4 ubiquitin ZYRO0G07876g similar to uniprot|Q07872 Saccharomyces cerevisiae YLL038C ENT4 Protein of unknown function contains an N-terminal epsin-like domain ZYRO0G07898g similar to uniprot|P32523 Saccharomyces cerevisiae YLL036C PRP19 Splicing factor associated with the spliceosome contains a U-box a motif found in a class of ubiquitin ligases ZYRO0G07920g similar to uniprot|P38738 Saccharomyces cerevisiae YHL029C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts ZYRO0G07942g no similarity ZYRO0G07964g weakly similar to uniprot|P33400 Saccharomyces cerevisiae YHL027W ZYRO0G07986g similar to uniprot|Q9P4W6 Saccharomyces cerevisiae YLL035W GRC3 Protein of unknown function required for cell growth and possibly involved in rRNA processing mRNA is cell cycle regulated ZYRO0G08008g highly similar to uniprot|Q07844 Saccharomyces cerevisiae YLL034C RIX7 Putative ATPase of the AAA family required for export of pre-ribosomal large subunits from the nucleus distributed between the nucleolus nucleoplasm and nuclear periphery depending on growth conditions ZYRO0G08030g similar to uniprot|P38740 Saccharomyces cerevisiae YHL026C Hypothetical ORF ZYRO0G08052g weakly similar to uniprot|P53148 Saccharomyces cerevisiae YGL093W SPC105 Protein required for accurate chromosome segregation localizes to the nuclear side of the spindle pole body forms a complex with Ydr532cp ZYRO0G08074g similar to uniprot|P49687 Saccharomyces cerevisiae YGL092W NUP145 Essential nucleoporin catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex ZYRO0G08096g highly similar to uniprot|P52920 Saccharomyces cerevisiae YGL091C NBP35 Essential nuclear protein evolutionarily conserved putative ATPase exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase delta ZYRO0G08118g some similarities with uniprot|P53150 Saccharomyces cerevisiae YGL090W LIF1 Protein involved in DNA double-strand break repair physically interacts with DNA ligase 4 (Lig4p) homologous to mammalian XRCC4 protein ZYRO0G08140g similar to uniprot|Q08925 Saccharomyces cerevisiae YPL184C Hypothetical ORF ZYRO0G08162g some similarities with uniprot|Q08926 Saccharomyces cerevisiae YPL186C UIP4 Protein of unknown function ZYRO0G08184g similar to uniprot|P01149 Saccharomyces cerevisiae YPL187W MF(ALPHA)1 Mating pheromone alpha-factor made by alpha cells interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating also encoded by MF(ALPHA)2 although MF(ALPHA)1 produces most alpha-factor ZYRO0G08206g highly similar to uniprot|Q06892 Saccharomyces cerevisiae YPL188W POS5 Mitochondrial NADH kinase phosphorylates NADH also phosphorylates NAD() with lower specificity required for the response to oxidative stress ZYRO0G08228g similar to uniprot|P28263 Saccharomyces cerevisiae YEL012W UBC8 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1 6-bisphosphatase (FBPase) cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro ZYRO0G08250g similar to uniprot|P40957 Saccharomyces cerevisiae YGL086W MAD1 Coiled-coil protein involved in the spindle-assembly checkpoint phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex forms a complex with Mad2p ZYRO0G08272g similar to uniprot|P53153 Saccharomyces cerevisiae YGL085W Hypothetical ORF ZYRO0G08294g similar to uniprot|P53154 Saccharomyces cerevisiae YGL084C GUP1 Multimembrane-spanning protein and similar to uniprot|Q08929 Saccharomyces cerevisiae YPL189W GUP2 ZYRO0G08316g similar to uniprot|P53009 Saccharomyces cerevisiae YGL083W SCY1 Suppressor of GTPase mutant ZYRO0G08338g similar to uniprot|Q3E823 Saccharomyces cerevisiae YPL189C-A ZYRO0G08360g similar to uniprot|P38996 Saccharomyces cerevisiae YPL190C NAB3 Single stranded DNA binding protein acidic ribonucleoprotein required for termination of non-poly(A) transcripts and efficient splicing interacts with Nrd1p ZYRO0G08382g similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs ZYRO0G08404g some similarities with uniprot|P53156 Saccharomyces cerevisiae YGL081W Hypothetical ORF ZYRO0G08426g some similarities with uniprot|Q08931 Saccharomyces cerevisiae YPL192C ZYRO0G08448g similar to uniprot|Q08932 Saccharomyces cerevisiae YPL193W RSA1 RiboSome Assembly ZYRO0G08470g similar to uniprot|P53157 Saccharomyces cerevisiae YGL080W FMP37 ZYRO0G08492g similar to uniprot|Q08949 Saccharomyces cerevisiae YPL194W DDC1 DNA damage checkpoint protein part of a PCNA-like complex required for DNA damage response required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates potential Cdc28p substrate ZYRO0G08514g similar to uniprot|Q7LIB1 Saccharomyces cerevisiae YPL195W APL5 Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function delta-like subunit of the yeast AP-3 adaptin component of the membrane-associated clathrin assembly complex ZYRO0G08536g similar to uniprot|P53158 Saccharomyces cerevisiae YGL079W Hypothetical ORF ZYRO0G08558g similar to uniprot|Q08952 Saccharomyces cerevisiae YPL196W OXR1 Protein of unknown function required for normal levels of resistance to oxidative damage null mutants are sensitive to hydrogen peroxide ZYRO0G08580g similar to uniprot|P20447 Saccharomyces cerevisiae YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis ZYRO0G08602g similar to uniprot|P19807 Saccharomyces cerevisiae YGL077C HNM1 Choline transporter (permease) that also controls the uptake of nitrogen mustard expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol ZYRO0G08624g highly similar to uniprot|P05737 Saccharomyces cerevisiae YGL076C RPL7A and to uniprot|Q12213 Saccharomyces cerevisiae YPL198W RPL7B Proteins component of the large (60S) ribosomal subunit ZYRO0G08690g similar to uniprot|Q08954 Saccharomyces cerevisiae YPL199C Hypothetical ORF ZYRO0G08712g weakly similar to uniprot|P53159 Saccharomyces cerevisiae YGL075C MPS2 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB) required for insertion of the newly duplicated SPB into the nuclear envelope potentially phosphorylated by Cdc28p ZYRO0G08734g similar to uniprot|P10961 Saccharomyces cerevisiae YGL073W HSF1 Trimeric heat shock transcription factor activates multiple genes in response to hyperthermia recognizes variable heat shock elements ZYRO0G08756g no similarity ZYRO0G08778g similar to uniprot|P22149 Saccharomyces cerevisiae YGL071W RCS1 Transcription factor involved in iron utilization and homeostasis binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability ZYRO0G08800g highly similar to uniprot|P27999 Saccharomyces cerevisiae YGL070C RPB9 RNA polymerase II subunit B12.6 contacts DNA mutations affect transcription start site ZYRO0G08822g similar to uniprot|P53163 Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid ZYRO0G08844g highly similar to uniprot|P06245 Saccharomyces cerevisiae YPL203W TPK2 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit ZYRO0G08866g similar to uniprot|P29295 Saccharomyces cerevisiae YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking gene expression DNA repair and chromosome segregation binds the CTD of RNA pol II homolog of mammalian casein kinase 1delta (CK1delta) ZYRO0G08888g highly similar to gnl|GLV|CAGL0J04400g Candida glabrata CAGL0J04400g and similar to YBL021C uniprot|P13434 Saccharomyces cerevisiae YBL021C HAP3 Subunit of the heme-activated glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression contains sequences contributing to both complex assembly and DNA binding ZYRO0G08910g similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria ZYRO0G08932g similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source part of the 4-aminobutyrate and glutamate degradation pathways localized to the cytoplasm ZYRO0G08954g conserved hypothetical protein ZYRO0G08976g highly similar to uniprot|P29469 Saccharomyces cerevisiae YBL023C MCM2 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex ZYRO0G08998g similar to uniprot|P38205 Saccharomyces cerevisiae YBL024W ZYRO0G09020g highly similar to gnl|GLV|CAGL0K01969g Candida glabrata CAGL0K01969g and similar to YBL025W uniprot|P38204 Saccharomyces cerevisiae YBL025W RRN10 subunit of UAF (upstream activation factor) involved in promoting high level transcription of rDNA Upstream activation factor subunit ZYRO0G09064g similar to uniprot|P40083 Saccharomyces cerevisiae YER137C Hypothetical ORF ZYRO0G09086g highly similar to uniprot|P38203 Saccharomyces cerevisiae YBL026W LSM2 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay ZYRO0G09108g highly similar to uniprot|P39958 Saccharomyces cerevisiae YER136W GDI1 GDP dissociation inhibitor regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins ZYRO0G09130g similar to uniprot|Q12298 Saccharomyces cerevisiae YDR061W Mitochondrial protein member of the ATP-binding cassette (ABC) transporter family transcriptionally activated by Yrm1p along with genes involved in multidrug resistance ZYRO0G09152g highly similar to uniprot|P40970 Saccharomyces cerevisiae YDR062W LCB2 Component of serine palmitoyltransferase responsible along with Lcb1p for the first committed step in sphingolipid synthesis which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine ZYRO0G09174g similar to uniprot|Q12156 Saccharomyces cerevisiae YDR063W Hypothetical ORF ZYRO0G09196g highly similar to uniprot|P05756 Saccharomyces cerevisiae YDR064W RPS13 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins ZYRO0G09284g similar to uniprot|P31755 Saccharomyces cerevisiae YGL038C OCH1 Mannosyltransferase of the cis-Golgi apparatus initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins ZYRO0G09306g similar to uniprot|P53184 Saccharomyces cerevisiae YGL037C PNC1 NAD() salvage pathway gene pyrazinamidase and nicotinamidase ZYRO0G09328g no similarity ZYRO0G09350g similar to uniprot|P53185 Saccharomyces cerevisiae YGL036W Mtf1 Two Hybrid Clone 2 ZYRO0G09372g similar to uniprot|P48234 Saccharomyces cerevisiae YGR145W ENP2 Essential nucleolar protein of unknown function contains WD repeats interacts with Mpp10p and Bfr2p and has homology to Spb1p ZYRO0G09394g similar to uniprot|Q752V4 Ashbya gossypii AFR469W SEC9 Protein transport protein SEC9 and weakly similar to YGR009C uniprot|P40357 Saccharomyces cerevisiae YGR009C SEC9 t- SNARE protein important for fusion of secretory vesicles with the plasma membrane ZYRO0G09416g weakly similar to uniprot|P48235 Saccharomyces cerevisiae YGR146C ZYRO0G09438g some similarities with uniprot|P27705 Saccharomyces cerevisiae YGL035C ZYRO0G09460g similar to uniprot|P53187 Saccharomyces cerevisiae YGL033W HOP2 Meiosis-specific protein that localizes to chromosomes preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair ZYRO0G09482g conserved hypothetical protein ZYRO0G09504g similar to gnl|GLV|KLLA0E10879g Kluyveromyces lactis KLLA0E10879g and some similarites with YGR147C uniprot|P37293 Saccharomyces cerevisiae YGR147C NAT2 N alpha- acetyl-transferase transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins ZYRO0G09526g similar to uniprot|P04449 Saccharomyces cerevisiae YGL031C RPL24A and to uniprot|P24000 Saccharomyces cerevisiae YGR148C RPL24B ZYRO0G09548g highly similar to uniprot|P14120 Saccharomyces cerevisiae YGL030W RPL30 Protein component of the large (60S) ribosomal subunit ZYRO0G09570g similar to uniprot|P48236 Saccharomyces cerevisiae YGR149W Hypothetical ORF ZYRO0G09592g similar to uniprot|P48237 Saccharomyces cerevisiae YGR150C Hypothetical ORF ZYRO0G09614g similar to uniprot|P53188 Saccharomyces cerevisiae YGL029W CGR1 Coiled-coil protein that may contribute to compartmentalization of nucleolar constituents expression is growth-regulated ZYRO0G09658g conserved hypothetical protein ZYRO0G09680g similar to uniprot|Q5AKC7 Candida albicans SCW11 Potential cell wall glucanase and some similarites with YGL028C uniprot|P53189 Saccharomyces cerevisiae ZYRO0G09702g similar to uniprot|P53008 Saccharomyces cerevisiae YGL027C CWH41 Processing alpha glucosidase I involved in assembly of cell wall beta 1 6 glucan and asparagine-linked protein glycosylation ER type II integral membrane N-glycoprotein disruption leads to a K1 killer toxin-resistant phenotype ZYRO0G09724g similar to uniprot|P32786 Saccharomyces cerevisiae YBL014C RRN6 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn7p and TATA-binding protein ZYRO0G09746g highly similar to uniprot|P00931 Saccharomyces cerevisiae YGL026C TRP5 tryptophan synthetase ZYRO0G09768g some similarities with uniprot|P40356 Saccharomyces cerevisiae YGL025C PGD1 Subunit of the Mediator global transcriptional cofactor complex which is part of the RNA polymerase II holoenzyme and plays an essential role in basal and activated transcription direct target of the Cyc8p-Tup1p transcriptional corepressor ZYRO0G09790g conserved hypothetical protein ZYRO0G09812g similar to uniprot|P32785 Saccharomyces cerevisiae YBL013W FMT1 Methionyl-tRNA formyltransferase catalyzes the formylation of initiator Met-tRNA in mitochondria potential Cdc28p substrate ZYRO0G09834g similar to uniprot|P32784 Saccharomyces cerevisiae YBL011W SCT1 High copy suppressor of choline-transport mutants ZYRO0G09856g weakly similar to uniprot|P53191 Saccharomyces cerevisiae YGL023C ZYRO0G09878g highly similar to uniprot|P39007 Saccharomyces cerevisiae YGL022W STT3 Subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis ZYRO0G09900g similar to uniprot|P32788 Saccharomyces cerevisiae YBL010C Hypothetical ORF ZYRO0G09922g some similarities with uniprot|P32789 Saccharomyces cerevisiae YBL009W haspin ZYRO0G09944g similar to uniprot|P53192 Saccharomyces cerevisiae YGL020C MDM39 Protein involved in determination of mitochondrial structure ZYRO0G09966g highly similar to uniprot|P43639 Saccharomyces cerevisiae YGL019W CKB1 beta (38kDa) subunit of protein kinase CK2 ZYRO0G09988g similar to uniprot|P53193 Saccharomyces cerevisiae YGL018C JAC1 Molecular chaperone involved with partner Ssq1p in assembly of Fe/S clusters and in mitochondrial iron metabolism contains a J domain typical to J-type chaperones localizes to the mitochondrial matrix ZYRO0G10010g similar to uniprot|P16639 Saccharomyces cerevisiae YGL017W ATE1 Arginyl-tRNA-protein transferase catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway ZYRO0G10032g similar to uniprot|P32767 Saccharomyces cerevisiae YGL016W KAP122 Karyopherin beta responsible for import of the Toa1p-Toa2p complex into the nucleus binds to nucleoporins Nup1p and Nup2p may play a role in regulation of pleiotropic drug resistance ZYRO0G10054g similar to uniprot|P32479 Saccharomyces cerevisiae YBL008W HIR1 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes contributes to nucleosome formation heterochromatic gene silencing and formation of functional kinetochores ZYRO0G10076g highly similar to uniprot|P07264 Saccharomyces cerevisiae YGL009C LEU1 Isopropylmalate isomerase catalyzes the second step in the leucine biosynthesis pathway ZYRO0G10098g similar to uniprot|P32790 Saccharomyces cerevisiae YBL007C SLA1 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton contains 3 SH3 domains interacts with proteins regulating actin dynamics and with proteins required for endocytosis ZYRO0G10120g similar to uniprot|P25338 Saccharomyces cerevisiae YGL010W Hypothetical ORF ZYRO0G10164g highly similar to uniprot|P21243 Saccharomyces cerevisiae YGL011C SCL1 Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7) ZYRO0G10186g similar to gnl|GLV|CAGL0E02761g Candida glabrata CAGL0E02761g and some similarites with YBL006C uniprot|P38210 Saccharomyces cerevisiae YBL006C LDB7 Protein of unknown function null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface ZYRO0G10208g highly similar to gnl|GLV|CAGL0A00429g Candida glabrata CAGL0A00429g and similar to YGL012W uniprot|P25340 Saccharomyces cerevisiae YGL012W ERG4 C- 24(28) sterol reductase catalyzes the final step in ergosterol biosynthesis mutants are viable but lack ergosterol ZYRO0G10230g no similarity ZYRO0G10252g similar to uniprot|P12383 Saccharomyces cerevisiae YGL013C PDR1 Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes ZYRO0G10274g similar to uniprot|P25339 Saccharomyces cerevisiae YGL014W PUF4 member of the PUF protein family YGL014W ZYRO0G10296g uniprot|P24545 Zygosaccharomyces rouxii Plasma membrane ATPase ZYRO0G10318g similar to uniprot|Q04894 Saccharomyces cerevisiae YMR318C ADH6 NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity may be involved in fusel alcohol synthesis or in aldehyde tolerance ZYRO0G10340g similar to uniprot|P39707 Saccharomyces cerevisiae YAR008W ZYRO0G10362g similar to uniprot|P38929 Saccharomyces cerevisiae YGL006W PMC1 May be involved in depleting cytosol of Ca2 ions putative vacuolar Ca2 ATPase ZYRO0G10384g similar to uniprot|P53195 Saccharomyces cerevisiae YGL005C COG7 Component of the conserved oligomeric Golgi complex ZYRO0G10406g similar to uniprot|P53196 Saccharomyces cerevisiae YGL004C RPN14 Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome localized to the cytoplasm ZYRO0G10428g highly similar to uniprot|P22336 Saccharomyces cerevisiae YAR007C RFA1 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination ZYRO0G10450g conserved hypothetical protein ZYRO0G10472g similar to uniprot|P53197 Saccharomyces cerevisiae YGL003C CDH1 CDC20 homolog 1 protein required for Clb2 and Ase1 degradation ZYRO0G10494g similar to uniprot|P39706 Saccharomyces cerevisiae YAR003W SWD1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres ZYRO0G10516g similar to uniprot|Q05359 Saccharomyces cerevisiae YAR002C-A ERP1 Protein that forms a heterotrimeric complex with Erp2p Emp24p and Erv25p member along with Emp24p and Erv25p of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles ZYRO0G10538g weakly similar to uniprot|P39705 Saccharomyces cerevisiae YAR002W NUP60 Subunit of the nuclear pore complex (NPC) functions to anchor Nup2p to the NPC in a dynamic process that is controlled by the nucleoplasmic concentration of Gsp1p-GTP potential Cdc28p substrate ZYRO0G10582g uniprot|Q96WU2 Zygosaccharomyces rouxii gl001 Putative C- 3 sterol dehydrogenase ZYRO0G10626g uniprot|Q96WU1 Zygosaccharomyces rouxii orf Hypothetical protein, highly similar to YGR001C uniprot|P53200 Saccharomyces cerevisiae YGR001C Protein with similarity to methyltransferase family members; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts ZYRO0G10648g similar to uniprot|P34111 Saccharomyces cerevisiae YAL001C TFC3 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding ZYRO0G10670g similar to uniprot|P39702 Saccharomyces cerevisiae YAL002W VPS8 involved in vacuolar protein sorting required for localization and trafficking of the CPY sorting receptor Vps8p is a membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2 binding motif. ZYRO0G10692g no similarity ZYRO0G10714g highly similar to uniprot|P32471 Saccharomyces cerevisiae YAL003W EFB1 Translation elongation factor 1 beta ZYRO0G10758g no similarity ZYRO0G10780g similar to uniprot|Q06168 Saccharomyces cerevisiae YLR321C SFH1 Involved in chromatin modeling cell cycle progression homolog of Snf5p member of the chromatin remodeling complex RSC ZYRO0G10802g weakly similar to uniprot|Q06162 Saccharomyces cerevisiae YLR315W NKP2 ZYRO0G10824g similar to uniprot|Q9URQ3 Saccharomyces cerevisiae YLR316C TAD3 tRNA-specific adenosine-34 deaminase subunit Tad3p ZYRO0G10846g similar to uniprot|Q06163 Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme essential for telomerase core catalytic activity involved in other aspects of telomerase assembly and function ZYRO0G10868g similar to uniprot|P41697 Saccharomyces cerevisiae YLR319C BUD6 Actin- and formin-interacting protein involved in actin cable nucleation and polarized cell growth isolated as bipolar budding mutant potential Cdc28p substrate ZYRO0G10890g weakly similar to uniprot|Q06164 Saccharomyces cerevisiae YLR320W MMS22 Protein involved in resistance to ionizing radiation acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks ZYRO0G10912g similar to uniprot|P53201 Saccharomyces cerevisiae YGR002C SWC4 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin component of the NuA4 histone acetyltransferase complex ZYRO0G10934g similar to uniprot|P53202 Saccharomyces cerevisiae YGR003W ZYRO0G10956g similar to uniprot|P53769 Saccharomyces cerevisiae YLR323C ZYRO0G10978g similar to uniprot|Q06169 Saccharomyces cerevisiae YLR324W PEX30 Peroxisomal integral membrane protein involved in negative regulation of peroxisome number partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p ZYRO0G11000g highly similar to uniprot|P49167 Saccharomyces cerevisiae YLR325C RPL38 Protein component of the large (60S) ribosomal subunit ZYRO0G11022g similar to uniprot|P41896 Saccharomyces cerevisiae YGR005C TFG2 transcription initiation factor TFIIF middle subunit ZYRO0G11044g similar to uniprot|P33411 Saccharomyces cerevisiae YGR006W PRP18 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing recruited to the spliceosome by Slu7p ZYRO0G11066g similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Hypothetical ORF ZYRO0G11088g similar to uniprot|P33412 YGR007W Saccharomyces cerevisiae MUQ1 Choline phosphate cytidylyltransferase ZYRO0G11110g similar to uniprot|Q06177 Saccharomyces cerevisiae YLR327C RBF9 Hypothetical ORF ZYRO0G11154g highly similar to uniprot|Q06178 Saccharomyces cerevisiae YLR328W NMA1 Nicotinic acid mononucleotide adenylyltransferase involved in NAD() salvage pathway ZYRO0G11176g some similarities with uniprot|Q07927 Saccharomyces cerevisiae YLR012C Hypothetical ORF ZYRO0G11198g highly similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF ZYRO0G11220g similar to uniprot|P53207 Saccharomyces cerevisiae YGR013W SNU71 associated with U1 snRNP (no counterpart in mammalian U1 snRNP contains few SR- RE- and RD-dipeptides U1 snRNP protein ZYRO0G11242g weakly similar to uniprot|P32334 Saccharomyces cerevisiae YGR014W MSB2 Mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway also functions as an osmosensor in parallel to the Sho1p-mediated pathway potential Cdc28p substrate ZYRO0G11264g similar to uniprot|P53208 Saccharomyces cerevisiae YGR015C Hypothetical ORF ZYRO0G11286g similar to uniprot|P53209 Saccharomyces cerevisiae YGR016W Hypothetical ORF ZYRO0G11308g similar to uniprot|Q02721 Saccharomyces cerevisiae YLR329W REC102 Protein involved in early stages of meiotic recombination required for chromosome synapsis forms a complex with Rec104p and Spo11p necessary during the initiation of recombination ZYRO0G11330g highly similar to uniprot|P53295 Saccharomyces cerevisiae YGR173W ZYRO0G11374g similar to uniprot|P42940 YGR207C Saccharomyces cerevisiae YGR2 Hypothetical ORF ZYRO0G11396g similar to uniprot|P42939 Saccharomyces cerevisiae YGR206W Hypothetical ORF ZYRO0G11418g highly similar to uniprot|P47096 Saccharomyces cerevisiae YJR025C BNA1 3-hydroxyanthranilic acid dioxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway ZYRO0G11440g similar to uniprot|P47095 Saccharomyces cerevisiae YJR024C Hypothetical ORF ZYRO0G11462g similar to uniprot|P47093 Saccharomyces cerevisiae YJR022W LSM8 Component of small nuclear ribonucleoprotein complexes involved in RNA processing and splicing ZYRO0G11506g similar to uniprot|P42938 Saccharomyces cerevisiae YGR205W Protein that binds ATP crystal structure resembles that of E.coli pantothenate kinase ZYRO0G11528g similar to uniprot|P41903 Saccharomyces cerevisiae YJR019C TES1 Thioesterase peroxisomal acyl-CoA thioesterase ZYRO0G11550g highly similar to uniprot|P07245 Saccharomyces cerevisiae YGR204W ADE3 Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase involved in single carbon metabolism and required for biosynthesis of purines thymidylate methionine and histidine ZYRO0G11572g highly similar to gnl|GLV|KLLA0E16610g Kluyveromyces lactis KLLA0E16610g and similar to YJR017C uniprot|P22696 Saccharomyces cerevisiae ESS1 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline ZYRO0G11594g similar to uniprot|P42937 YGR203W Saccharomyces cerevisiae Probable protein tyrosine phosphatase of the CDC25-like phosphatase family ZYRO0G11616g similar to uniprot|P33412 YGR007W Saccharomyces cerevisiae MUQ1 Choline phosphate cytidylyltransferase ZYRO0G11638g highly similar to uniprot|P39522 Saccharomyces cerevisiae YJR016C ILV3 Dihydroxyacid dehydratase catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids ZYRO0G11660g similar to uniprot|P42935 Saccharomyces cerevisiae YGR200C ELP2 Elongator protein part of the six-subunit RNA polymerase II Elongator histone acetyltransferase complex target of Kluyveromyces lactis zymocin ZYRO0G11682g similar to uniprot|P42934 Saccharomyces cerevisiae YGR199W PMT6 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase ZYRO0G11704g some similarities with uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner ZYRO0G11726g highly similar to uniprot|P32318 Saccharomyces cerevisiae YGR144W THI4 Protein required for thiamine biosynthesis and for mitochondrial genome stability ZYRO0G11748g similar to uniprot|P46951 Saccharomyces cerevisiae YGR198W Essential protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0G11770g similar to uniprot|P47089 Saccharomyces cerevisiae YJR014W RBF22 Hypothetical ORF ZYRO0G11792g some similarities with uniprot|P46949 Saccharomyces cerevisiae YGR196C FYV8 Protein of unknown function required for survival upon exposure to K1 killer toxin ZYRO0G11814g highly similar to uniprot|P46948 Saccharomyces cerevisiae YGR195W SKI6 superkiller ExtraCellular Mutant Ribosomal RNA Processing homolog of RNAse PH ZYRO0G11836g similar to uniprot|P47088 Saccharomyces cerevisiae YJR013W GPI14 Glycosylphosphatidylinositol-alpha 1 4 mannosyltransferase I involved in GPI anchor biosynthesis requires Pbn1p for function homolog of mammalian PIG-M ZYRO0G11858g some similarities with uniprot|P47087 Saccharomyces cerevisiae YJR012C Protein required for cell viability ZYRO0G11880g conserved hypothetical protein ZYRO0G11902g similar to uniprot|P47086 Saccharomyces cerevisiae YJR011C Hypothetical ORF ZYRO0G11924g similar to uniprot|P46965 Saccharomyces cerevisiae YJR010C-A SPC1 Subunit of the signal peptidase complex (SPC) which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER) homolog of the SPC12 subunit of mammalian signal peptidase complex ZYRO0G11946g similar to uniprot|P42826 Saccharomyces cerevisiae YGR194C; XKS1 third enzyme in the xylose pathway, Xylulokinase ZYRO0G11968g similar to uniprot|P16451 Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core ZYRO0G11990g highly similar to uniprot|P08536 Saccharomyces cerevisiae YJR010W MET3 ATP sulfurylase catalyzes the primary step of intracellular sulfate activation essential for assimilatory reduction of sulfate to sulfide involved in methionine metabolism ZYRO0G12012g uniprot|P08439 Zygosaccharomyces rouxii Glyceraldehyde-3- phosphate dehydrogenase ZYRO0G12034g similar to uniprot|P47085 Saccharomyces cerevisiae YJR008W Hypothetical ORF ZYRO0G12056g highly similar to uniprot|P20459 Saccharomyces cerevisiae YJR007W SUI2 Alpha subunit of the translation initiation factor eIF2 involved in the identification of the start codon phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP ZYRO0G12078g conserved hypothetical protein ZYRO0G12100g no similarity ZYRO0G12144g highly similar to uniprot|P53301 Saccharomyces cerevisiae YGR189C CRH1 Putative glycosidase of the cell wall may have a role in cell wall architecture ZYRO0G12188g similar to uniprot|P47076 Saccharomyces cerevisiae YJL011C RPC17 RNA polymerase III subunit C17 physically interacts with C31 C11 and TFIIIB70 may be involved in the recruitment of pol III by the preinitiation complex ZYRO0G12210g highly similar to uniprot|P47075 Saccharomyces cerevisiae YJL012C VTC4 Phosphate metabolism transcription is regulated by PHO system polyphosphate synthetase (putative) ZYRO0G12232g similar to uniprot|P41695 Saccharomyces cerevisiae YGR188C BUB1 Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage associates with centromere DNA via Skp1p ZYRO0G12254g highly similar to uniprot|P39077 Saccharomyces cerevisiae YJL014W CCT3 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo ZYRO0G12276g weakly similar to uniprot|P47072 Saccharomyces cerevisiae YJL016W ZYRO0G12298g weakly similar to uniprot|P47069 Saccharomyces cerevisiae YJL019W MPS3 Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion localizes to the spindle pole body half bridge interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p ZYRO0G12320g highly similar to uniprot|P53292 Saccharomyces cerevisiae YGR165W MRPS35 Mitochondrial ribosomal protein of the small subunit ZYRO0G12342g similar to uniprot|P41815 Saccharomyces cerevisiae YDR046C BAP3 Amino acid permease involved in the uptake of cysteine leucine isoleucine and valine ZYRO0G12364g conserved hypothetical protein ZYRO0G12386g similar to uniprot|Q7LHX4 Saccharomyces cerevisiae YDR051C Hypothetical ORF ZYRO0G12408g highly similar to uniprot|P00942 Saccharomyces cerevisiae YDR050C TPI1 induced under stress conditions triosephosphate isomerase ZYRO0G12430g similar to uniprot|P38242 Saccharomyces cerevisiae YBR070C ALG14 Essential protein required for the second step of dolichyl-linked oligosaccharide synthesis; involved in N-linked glycosylation; similar to bacterial glycosyltransferases ZYRO0G12452g no similarity ZYRO0G12474g similar to uniprot|P38086 Saccharomyces cerevisiae YBR073W RDH54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis proposed to be involved in crossover interference ZYRO0G12496g similar to uniprot|Q66RH0 Saccharomyces cerevisiae YDR049W Hypothetical ORF ZYRO0G12518g highly similar to uniprot|P32347 Saccharomyces cerevisiae YDR047W HEM12 Uroporphyrinogen decarboxylase catalyzes the fifth step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus activity inhibited by Cu2 Zn2 Fe2 Fe3 and sulfhydryl-specific reagents ZYRO0G12540g similar to uniprot|P38244 Saccharomyces cerevisiae YBR074W Hypothetical ORF ZYRO0G12562g conserved hypothetical protein ZYRO0G12584g conserved hypothetical protein ZYRO0G12606g similar to uniprot|P32325 Saccharomyces cerevisiae YDR052C DBF4 Regulatory subunit of Cdc7p-Dbf4p kinase complex required for Cdc7p kinase activity and initiation of DNA replication phosphorylates the Mcm2-7 family of proteins cell cycle regulated ZYRO0G12628g similar to uniprot|P38247 Saccharomyces cerevisiae YBR077C SLM4 Protein with a potential role in actin cytoskeleton organization possible component of the TOR nutrient signaling pathway gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase ZYRO0G12650g highly similar to uniprot|Q750Z0 Ashbya gossypii AGL203C AGL203Cp and similar to YDR054C uniprot|P14682 Saccharomyces cerevisiae YDR054C CDC34 Ubiquitin-conjugating enzyme or E2 together with Skp1p Rbx1p Cdc53p and an F-box protein forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation ZYRO0G12672g similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 ZYRO0G12694g similar to uniprot|Q12355 Saccharomyces cerevisiae YDR055W PST1 Cell wall protein and similar to uniprot|P38248 Saccharomyces cerevisiaeYBR078W ECM33 ZYRO0G12716g similar to uniprot|P38249 Saccharomyces cerevisiae YBR079C RPG1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes ZYRO0G12738g highly similar to uniprot|P18759 Saccharomyces cerevisiae YBR080C SEC18 ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport homolog of the mammalian NSF ZYRO0G12760g similar to uniprot|Q12025 Saccharomyces cerevisiae YDR056C Hypothetical ORF ZYRO0G12782g weakly similar to uniprot|Q04313 Saccharomyces cerevisiae YDR057W YOS9 Glycoprotein of the ER membrane involved in ER-to-Golgi transport of glycosylphosphatidylinositol (GPI)-anchored proteins ZYRO0G12804g similar to uniprot|P35177 Saccharomyces cerevisiae YBR081C SPT7 Subunit of the SAGA transcriptional regulatory complex involved in proper assembly of the complex also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex ZYRO0G12870g highly similar to uniprot|P15731 Saccharomyces cerevisiae YBR082C UBC4 Ubiquitin-conjugating enzyme that mediates degradation of short-lived and abnormal proteins interacts with E3-CaM in ubiquitinating calmodulin interacts with many SCF ubiquitin protein ligases component of the cellular stress response ZYRO0G12892g similar to uniprot|Q12176 Saccharomyces cerevisiae YDR060W MAK21 Protein required for large (60S) ribosomal subunit biogenesis involved in nuclear export of pre-ribosomes required for maintenance of dsRNA virus homolog of human CAATT-binding protein ZYRO0G12914g some similarities with uniprot|P18412 Saccharomyces cerevisiae YBR083W TEC1 transcription factor of the TEA/ATTS DNA-binding domain family regulator of Ty1 expression ZYRO0G12936g highly similar to uniprot|P09440 Saccharomyces cerevisiae YBR084W MIS1 Mitochondrial C1-tetrahydrofolate synthase involved in interconversion between different oxidation states of tetrahydrofolate (THF) provides activities of formyl-THF synthetase methenyl-THF cyclohydrolase and methylene-THF dehydrogenase ZYRO0G12958g highly similar to uniprot|P05735 Saccharomyces cerevisiae YBR084C-A RPL19A and to uniprot|P05735 Saccharomyces cerevisiae YBL027W RPL19B Proteins component of the large (60S) ribosomal subunit ZYRO0G12980g similar to uniprot|P38202 Saccharomyces cerevisiae YBL028C Hypothetical ORF ZYRO0G13002g some similarities with uniprot|P38201 Saccharomyces cerevisiae YBL029W Hypothetical ORF ZYRO0G13046g similar to uniprot|Q3E756 Saccharomyces cerevisiae YBL029C-A Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery has potential orthologs in Saccharomyces species and in Yarrowia lipolytica ZYRO0G13068g highly similar to uniprot|P18239 Saccharomyces cerevisiae YBL030C PET9 Major ADP/ATP carrier of the mitochondrial inner membrane exchanges cytosolic ADP for mitochondrially synthesized ATP Pet9p and Sal1p have an overlapping function critical for viability ZYRO0G13090g weakly similar to uniprot|P38200 Saccharomyces cerevisiae YBL031W SHE1 Cytoskeletal protein of unknown function overexpression causes growth arrest ZYRO0G13112g similar to uniprot|P38199 Saccharomyces cerevisiae YBL032W ZYRO0G13134g similar to uniprot|P38066 Saccharomyces cerevisiae YBL033C RIB1 GTP cyclohydrolase II catalyzes the first step of the riboflavin biosynthesis pathway ZYRO0G13156g highly similar to uniprot|O43137 Saccharomyces cerevisiae YBR085C-A Hypothetical ORF ZYRO0G13178g similar to uniprot|P38198 Saccharomyces cerevisiae YBL034C STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p) required for interpolar microtubules to provide an outward force on the spindle poles ZYRO0G13200g similar to uniprot|P38121 Saccharomyces cerevisiae YBL035C POL12 Subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis ZYRO0G13222g weakly similar to uniprot|P38250 Saccharomyces cerevisiae YBR086C IST2 ZYRO0G13244g weakly similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF ZYRO0G13288g similar to uniprot|Q04835 Saccharomyces cerevisiae YMR253C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ZYRO0G13310g no similarity ZYRO0G13332g similar to uniprot|Q05667 Saccharomyces cerevisiae YOL053W Hypothetical ORF ZYRO0G13354g no similarity ZYRO0G13376g some similarities with uniprot|Q12161 Saccharomyces cerevisiae YOL054W PSH1 Nuclear protein putative RNA polymerase II elongation factor isolated as Pob3p/Spt16p-binding protein ZYRO0G13398g similar to uniprot|P08468 Saccharomyces cerevisiae YMR257C PET111 Specific translational activator for the COX2 mRNA located in the mitochondrial inner membrane ZYRO0G13420g similar to uniprot|Q04847 Saccharomyces cerevisiae YMR258C Hypothetical ORF ZYRO0G13464g similar to uniprot|Q03496 Saccharomyces cerevisiae YMR259C Hypothetical ORF ZYRO0G13486g highly similar to uniprot|P38912 Saccharomyces cerevisiae YMR260C TIF11 Translation initiation factor eIF1A ZYRO0G13508g similar to uniprot|P38426 Saccharomyces cerevisiae YMR261C TPS3 115 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex ZYRO0G13530g similar to uniprot|P38430 Saccharomyces cerevisiae YMR262W Hypothetical ORF ZYRO0G13552g similar to uniprot|P38429 Saccharomyces cerevisiae YMR263W SAP30 Subunit of a histone deacetylase complex along with Rpd3p and Sin3p that is involved in silencing at telomeres rDNA and silent mating-type loci ZYRO0G13574g similar to uniprot|P38428 Saccharomyces cerevisiae YMR264W CUE1 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination ZYRO0G13596g similar to uniprot|Q04199 Saccharomyces cerevisiae YML102W CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA required for building functional kinetochores conserved from yeast to humans ZYRO0G13618g similar to uniprot|Q03508 Saccharomyces cerevisiae YMR265C Hypothetical ORF ZYRO0G13640g similar to uniprot|Q03516 Saccharomyces cerevisiae YMR266W RSN1 Overexpression rescues sro7/sop1 in NaCl. Encodes a membrane protein. ZYRO0G13662g similar to uniprot|P28239 Saccharomyces cerevisiae YMR267W PPA2 Mitochondrial inorganic pyrophosphatase required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate ZYRO0G13684g similar to uniprot|P52593 Saccharomyces cerevisiae YML103C NUP188 Subunit of the nuclear pore complex (NPC) ZYRO0G13706g similar to uniprot|P49960 Saccharomyces cerevisiae YMR268C PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling ZYRO0G13728g weakly similar to uniprot|Q03525 Saccharomyces cerevisiae YMR269W ZYRO0G13750g similar to uniprot|Q01846 Saccharomyces cerevisiae YML104C MDM1 Intermediate filament protein required for nuclear and mitochondrial transmission to daughter buds ZYRO0G13772g similar to uniprot|P53437 Saccharomyces cerevisiae YMR270C RRN9 Upstream activation factor subunit ZYRO0G13794g highly similar to uniprot|P29478 Saccharomyces cerevisiae YML105C SEC65 signal recognition particle subunit homologue of mammalian SRP19 ZYRO0G13816g highly similar to uniprot|P13298 Saccharomyces cerevisiae YML106W URA5 Fifth step in pyrimidine biosynthesis pathway Orotate phosphoribosyltransferase 1 ZYRO0G13838g weakly similar to uniprot|Q03760 Saccharomyces cerevisiae YML107C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery ZYRO0G13948g similar to uniprot|Q03529 Saccharomyces cerevisiae YMR272C SCS7 Required for the hydroxylation of the very long chain fatty acid (VLCFA) located in the endoplasmic reticulum desaturase/hydroxylase enzyme ZYRO0G13970g highly similar to uniprot|Q03759 Saccharomyces cerevisiae YML108W defines a new subfamily of the split beta-alpha-beta sandwiches. ZYRO0G13992g similar to uniprot|P54786 Saccharomyces cerevisiae YML109W ZDS2 Protein that interacts with silencing proteins at the telomere involved in transcriptional silencing paralog of Zds1p ZYRO0G14014g similar to uniprot|Q03530 Saccharomyces cerevisiae YMR274C RCE1 Type II CAAX prenyl protease ZYRO0G14036g highly similar to gnl|GLV|CAGL0J06710g Candida glabrata CAGL0J06710g and similar to YML110C uniprot|P49017 Saccharomyces cerevisiae YML110C COQ5 2- hexaprenyl-6-methoxy-1 4-benzoquinone methyltransferase involved in ubiquinone (Coenzyme Q) biosynthesis located in mitochondria ZYRO0G14058g similar to uniprot|Q03758 Saccharomyces cerevisiae YML111W BUL2 Component of the Rsp5p E3-ubiquitin ligase complex involved in intracellular amino acid permease sorting functions in heat shock element mediated gene expression essential for growth in stress conditions functional homolog of BUL1 ZYRO0G14080g similar to uniprot|P46963 Saccharomyces cerevisiae YML112W CTK3 Gamma subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing ZYRO0G14102g some similarities with uniprot|P13483 Saccharomyces cerevisiae YML113W ZYRO0G14124g similar to uniprot|P48510 Saccharomyces cerevisiae YMR276W DSK2 Nuclear-enriched ubiquitin-like polyubiquitin-binding protein required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle involved in proteolysis interacts with the proteasome ZYRO0G14146g weakly similar to uniprot|Q03750 Saccharomyces cerevisiae YML114C TAF8 TFIID subunit (65 kDa) involved in RNA polymerase II transcription initiation ZYRO0G14168g similar to uniprot|Q03254 Saccharomyces cerevisiae YMR277W FCP1 Carboxy-terminal domain (CTD) phosphatase ZYRO0G14190g similar to uniprot|Q03262 Saccharomyces cerevisiae YMR278W Hypothetical ORF ZYRO0G14212g similar to uniprot|Q12525 Saccharomyces cerevisiae YLL062C MHT1 S-methylmethionine-homocysteine methyltransferase ZYRO0G14234g similar to uniprot|P23642 Saccharomyces cerevisiae YML115C VAN1 Mannosyltransferase with a role in protein N-glycosylation ZYRO0G14256g similar to uniprot|Q03735 Saccharomyces cerevisiae YML117W NAB6 Putative RNA-binding protein based on computational analysis of large-scale protein-protein interaction data ZYRO0G14278g similar to uniprot|Q75DZ4 Ashbya gossypii ABL121C ABL121Cp and similar to YMR280C uniprot|P39113 Saccharomyces cerevisiae YMR280C CAT8 Zinc cluster transcriptional activator ZYRO0G14300g similar to uniprot|P23797 Saccharomyces cerevisiae YMR281W GPI12 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate functional homolog of human PIG-Lp ZYRO0G14322g weakly similar to uniprot|P22136 Saccharomyces cerevisiae YMR282C AEP2 Mitochondrial protein likely involved in translation of the mitochondrial OLI1 mRNA exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader ZYRO0G14344g similar to uniprot|P23796 Saccharomyces cerevisiae YMR283C RIT1 Modifies initiator methionine tRNA to distinguish it from elongator methionine tRNA Initiator methionine tRNA 2'-O-ribosyl phosphate transferase ZYRO0G14388g highly similar to uniprot|P09938 Saccharomyces cerevisiae YJL026W RNR2 Ribonucleotide-diphosphate reductase (RNR) small subunit the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits ZYRO0G14454g weakly similar to uniprot|O00033 Saccharomyces cerevisiae YOR078W BUD21 Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA originally isolated as bud-site selection mutant that displays a random budding pattern ZYRO0G14476g some similarities with uniprot|Q12067 Saccharomyces cerevisiae YOR079C ATX2 Golgi membrane protein involved in manganese homeostasis overproduction suppresses the sod1 (copper zinc superoxide dismutase) null mutation ZYRO0G14498g similar to gnl|GLV|CAGL0K05599g Candida glabrata CAGL0K05599g and weakly similar to YOR080W uniprot|Q7LGN4 Saccharomyces cerevisiae YOR080W DIA2 Protein of unknown function involved in invasive and pseudohyphal growth ZYRO0G14520g similar to uniprot|P36165 YKR089C Saccharomyces cerevisiae STC1 Protein of unknown function found in lipid particles potential Cdc28p substrate ZYRO0G14542g weakly similar to uniprot|P36166 Saccharomyces cerevisiae YKR090W PXL1 LIM domain-containing protein that localizes to sites of polarized growth ZYRO0G14564g weakly similar to uniprot|Q12416 Saccharomyces cerevisiae YOR083W WHI5 Protein that regulates the critical cell size required for passage through Start and commitment to cell division may act upstream of SCB binding factor (SBF) and MCB binding factor (MBF) periodically expressed in G1 ZYRO0G14586g similar to uniprot|Q12405 Saccharomyces cerevisiae YOR084W Putative lipase of the peroxisomal matrix transcriptionally activated by Yrm1p along with genes involved in multidrug resistance ZYRO0G14608g some similarities with uniprot|P32583 Saccharomyces cerevisiae YKR092C SRP40 Suppressor of mutant AC40 subunit of RNA polymerase I and III nucleolar protein that is immunologically and structurally related to rat Nopp140 a nonribosomal protein of the nucleolus and coiled bodies ZYRO0G14630g highly similar to uniprot|Q00578 Saccharomyces cerevisiae YIL143C SSL2 ZYRO0G14652g similar to uniprot|P40460 Saccharomyces cerevisiae YIL144W TID3 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p) conserved coiled-coil protein involved in chromosome segregation spindle checkpoint activity kinetochore assembly and clustering ZYRO0G14674g similar to uniprot|P40088 Saccharomyces cerevisiae YER145C FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane forms complex with Fet3p expression is regulated by iron ZYRO0G14696g highly similar to uniprot|Q74ZR8 Ashbya gossypii AGR130W AGR130Wp and similar to YER146W uniprot|P40089 Saccharomyces cerevisiae YER146W LSM5 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay ZYRO0G14718g similar to uniprot|P38954 Saccharomyces cerevisiae YDR072C IPT1 Inositolphosphotransferase 1 involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C) which is the most abundant sphingolipid in cells mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media ZYRO0G14740g similar to gnl|GLV|CAGL0G05329g Candida glabrata CAGL0G05329g and some similarites with YDR073W uniprot|P38956 Saccharomyces cerevisiae YDR073W SNF11 component of SWI/SNF global transcription activator complex ZYRO0G14762g uniprot|Q9P4D3 Zygosaccharomyces rouxii TPS2 Trehalose-6- phosphate phosphatase and similar to YDR074W uniprot|P31688 Saccharomyces cerevisiae YDR074W TPS2 Trehalose-6- phosphate phosphatase ZYRO0G14784g similar to uniprot|P40090 Saccharomyces cerevisiae YER147C SCC4 ZYRO0G14806g highly similar to uniprot|P13393 Saccharomyces cerevisiae YER148W SPT15 TATA-binding protein general transcription factor that interacts with other factors to form the preinitiation complex at promoters essential for viability ZYRO0G14828g weakly similar to uniprot|Q70DD8 Saccharomyces cerevisiae YER149C PEA2 Coiled-coil polarisome protein required for polarized morphogenesis cell fusion and low affinity Ca2 influx forms polarisome complex with Bni1p Bud6p and Spa2p localizes to sites of polarized growth ZYRO0G14850g highly similar to uniprot|P32345 Saccharomyces cerevisiae YDR075W PPH3 Catalytic subunit of protein phosphatase involved in activation of Gln3p which is a transcription factor with a role in nitrogen utilization ZYRO0G14872g weakly similar to uniprot|P38953 Saccharomyces cerevisiae YDR076W RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad57p ZYRO0G14894g some similarities with uniprot|Q01589 Saccharomyces cerevisiae YDR077W SED1 Isolated as a suppressor of an erd2 deletion mutant (ERD2 is the HDEL receptor that sorts ER proteins) SED1 encodes a cell wall protein. ZYRO0G14916g similar to uniprot|P38329 Saccharomyces cerevisiae YBR235W Hypothetical ORF ZYRO0G14938g highly similar to uniprot|P32783 Saccharomyces cerevisiae YBR236C ABD1 Methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA ZYRO0G14960g similar to uniprot|P21372 Saccharomyces cerevisiae YBR237W PRP5 RNA helicase in the DEAD-box family ZYRO0G14982g similar to uniprot|P53139 Saccharomyces cerevisiae YGL108C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery ZYRO0G15004g similar to uniprot|P38330 Saccharomyces cerevisiae YBR238C Hypothetical ORF ZYRO0G15026g similar to uniprot|P47029 Saccharomyces cerevisiae YJL084C Cytoplasmic protein of unknown function that interacts with Pcl7p phosphorylated in vitro potential Cdc28p substrate ZYRO0G15048g similar to uniprot|P19658 YJL085W Saccharomyces cerevisiae EXO70 Essential 70kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) ZYRO0G15070g similar to uniprot|P09880 YJL087C Saccharomyces cerevisiae TRL1 tRNA ligase ZYRO0G15092g highly similar to gnl|GLV|CAGL0I10791g Candida glabrata CAGL0I10791g and similar to uniprot|P05150 YJL088W Saccharomyces cerevisiae ARG3 Ornithine carbamoyltransferase ZYRO0G15114g weakly similar to uniprot|P36118 Saccharomyces cerevisiae YKR022C Protein required for cell viability ZYRO0G15136g weakly similar to uniprot|P46954 Saccharomyces cerevisiae YJL089W SIP4 Possibly involved in Snf1p regulated transcriptional activation shows homology to DNA binding domain of Gal4p has a leucine zipper motif and acidic region lexA-Sip4p activates transcription ZYRO0G15180g similar to uniprot|P47027 Saccharomyces cerevisiae YJL090C DPB11 Essential BRCT repeat protein required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis also required for S/M checkpoint control ZYRO0G15202g similar to uniprot|P47026 Saccharomyces cerevisiae YJL091C GWT1 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI) an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors ZYRO0G15224g similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W HPR5 DNA helicase and DNA-dependent ATPase involved in DNA repair required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II potential Cdc28p substrate ZYRO0G15246g similar to uniprot|P40310 Saccharomyces cerevisiae YJL093C TOK1 Target Of K1 Killer Toxin outward-rectifier potassium channel ZYRO0G15268g similar to uniprot|P40309 Saccharomyces cerevisiae YJL094C KHA1 Putative K /H antiporter ZYRO0G15290g similar to uniprot|Q01389 Saccharomyces cerevisiae YJL095W BCK1 Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway which controls cell integrity upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p ZYRO0G15312g similar to gnl|GLV|CAGL0L03542g Candida glabrata CAGL0L03542g and some similarites with YJL096W uniprot|P40858 Saccharomyces cerevisiae YJL096W MRPL49 Mitochondrial ribosomal protein of the large subunit ZYRO0G15334g similar to uniprot|P40857 Saccharomyces cerevisiae YJL097W Protein required for cell viability ZYRO0G15356g similar to uniprot|P36123 Saccharomyces cerevisiae or to YJL098W uniprot|P40856 Saccharomyces cerevisiae YJL098W ZYRO0G15378g some similarities with uniprot|P38765 Saccharomyces cerevisiae YHR029C Hypothetical ORF ZYRO0G15400g similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W GRE2 NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase) stress induced (osmotic ionic oxidative heat shock and heavy metals) regulated by the HOG pathway ZYRO0G15422g similar to uniprot|Q2UJ53 Aspergillus oryzae AO090003001353 Synaptic vesicle transporter SVOP and related transporters and weakly similar to YBR008C uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs ZYRO0G15444g weakly similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism ZYRO0G15466g weakly similar to uniprot|P47177 Saccharomyces cerevisiae YJR149W ZYRO0G15488g some similarities with uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate-terminated RNA mRNA capping enzyme beta subunit (80 kDa) RNA 5'-triphosphatase ZYRO0G15510g no similarity ZYRO0G15554g similar to uniprot|Q08748 Saccharomyces cerevisiae YOR296W Hypothetical ORF ZYRO0G15576g similar to uniprot|Q05024 Saccharomyces cerevisiae YMR233W Interacts with Top1p in 2-hybrid assay. ZYRO0G15598g similar to uniprot|Q08746 Saccharomyces cerevisiae YOR294W RRS1 Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis mouse homolog shows altered expression in Huntington's disease model mice ZYRO0G15620g similar to uniprot|Q05670 Saccharomyces cerevisiae YMR232W FUS2 Cytoplasmic protein localized to the shmoo tip required for the alignment of parental nuclei before nuclear fusion during mating ZYRO0G15642g similar to uniprot|P12868 Saccharomyces cerevisiae YMR231W PEP5 Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins also interacts with Pep7p ZYRO0G15664g highly similar to uniprot|P46784 Saccharomyces cerevisiae YMR230W RPS10B and to uniprot|Q08745 Saccharomyces cerevisiae YOR293W RPS10A Proteins component of the small (40S) ribosomal subunit ZYRO0G15686g similar to uniprot|Q08743 Saccharomyces cerevisiae YOR292C Hypothetical ORF ZYRO0G15708g similar to uniprot|Q12697 Saccharomyces cerevisiae YOR291W Hypothetical ORF ZYRO0G15730g similar to uniprot|Q05022 Saccharomyces cerevisiae YMR229C RRP5 Part of small ribosomal subunit (SSU) processosome containing U3 snoRNA) required for the synthesis of both 18S and 5.8S rRNAs ZYRO0G15752g similar to uniprot|P14908 Saccharomyces cerevisiae YMR228W MTF1 Mitochondrial RNA polymerase sigma-like specificity factor required for promoter recognition interacts with mitochondrial core polymerase Rpo41p imported into mitochondria via a novel process requiring most of the Mtf1p sequence ZYRO0G15774g weakly similar to uniprot|Q05021 Saccharomyces cerevisiae YMR227C TAF7 TFIID subunit (67 kDa) involved in RNA polymerase II transcription initiation ZYRO0G15796g similar to uniprot|P22082 Saccharomyces cerevisiae YOR290C SNF2 involved in the coordinate regulation of phospholipid synthesis transcriptional regulator ZYRO0G15818g highly similar to uniprot|P33416 Saccharomyces cerevisiae YDR258C HSP78 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock prevents the aggregation of misfolded matrix proteins component of the mitochondrial proteolysis system ZYRO0G15840g similar to uniprot|P15992 Saccharomyces cerevisiae YBR072W HSP26 Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer induced by heat upon entry into stationary phase and during sporulation ZYRO0G15862g similar to uniprot|Q12379 Saccharomyces cerevisiae YDR260C SWM1 Spore Wall Maturation 1 ZYRO0G15884g similar to uniprot|P52911 Saccharomyces cerevisiae YDR261C EXG2 Exo-1 3-beta-glucanase involved in cell wall beta-glucan assembly may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor ZYRO0G15906g weakly similar to uniprot|Q99234 Saccharomyces cerevisiae YOR030W DFG16 Probable multiple transmembrane protein involved in invasive growth upon nitrogen starvation ZYRO0G15950g some similarities with uniprot|Q12331 Saccharomyces cerevisiae YDR262W Hypothetical ORF ZYRO0G15972g some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C HMS1 C2H2 zinc-finger protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant ZYRO0G15994g highly similar to uniprot|P17423 Saccharomyces cerevisiae YHR025W THR1 homoserine kinase ZYRO0G16016g similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole ZYRO0G16038g similar to uniprot|P38764 Saccharomyces cerevisiae YHR027C RPN1 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome may participate in the recognition of several ligands of the proteasome contains a leucine-rich repeat (LRR) domain a site for protein? protein interactions ZYRO0G16060g similar to uniprot|P18962 Saccharomyces cerevisiae YHR028C ZYRO0G16082g highly similar to uniprot|Q00772 Saccharomyces cerevisiae YHR030C SLT2 Suppressor of lyt2 serine/threonine MAP kinase ZYRO0G16104g similar to uniprot|P38766 Saccharomyces cerevisiae YHR031C RRM3 DNA helicase involved in rDNA replication and Ty1 transposition structurally and functionally related to Pif1p ZYRO0G16126g similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W Hypothetical ORF ZYRO0G16148g similar to uniprot|P38779 Saccharomyces cerevisiae YHR052W CIC1 Core interacting component 1 ribosome biogenesis protein ZYRO0G16170g similar to uniprot|P36053 Saccharomyces cerevisiae YKL160W ELF1 Protein of unknown function deletion inhibits Brome mosaic virus expression ZYRO0G16192g similar to uniprot|P00427 Saccharomyces cerevisiae YHR051W COX6 Subunit VI of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain expression is regulated by oxygen levels ZYRO0G16214g weakly similar to uniprot|P36054 Saccharomyces cerevisiae YKL159C ZYRO0G16236g similar to uniprot|P38778 Saccharomyces cerevisiae YHR050W SMF2 Divalent metal ion transporter ZYRO0G16258g highly similar to gnl|GLV|CAGL0J00385g Candida glabrata CAGL0J00385g and similar to YHR049W uniprot|P38777 Saccharomyces cerevisiae ZYRO0G16280g no similarity ZYRO0G16302g similar to uniprot|P38776 Saccharomyces cerevisiae YHR048W Hypothetical ORF ZYRO0G16324g highly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to YHR047C uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase ZYRO0G16346g highly similar to uniprot|P38710 Saccharomyces cerevisiae YHR046C INM1 Inositol monophosphatase involved in biosynthesis of inositol and in phosphoinositide second messenger signaling INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate ZYRO0G16368g similar to uniprot|P38775 Saccharomyces cerevisiae YHR045W Hypothetical ORF ZYRO0G16390g similar to uniprot|Q6Q5R1 Saccharomyces cerevisiae YDR279W RNH202 Ribonuclease H2 subunit required for RNase H2 activity ZYRO0G16412g highly similar to uniprot|Q05636 Saccharomyces cerevisiae YDR280W RRP45 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'->5' exonucleases ZYRO0G16434g no similarity ZYRO0G16456g similar to uniprot|P38774 Saccharomyces cerevisiae YHR044C ZYRO0G16478g similar to uniprot|Q05648 Saccharomyces cerevisiae YDR282C Hypothetical ORF ZYRO0G16500g similar to uniprot|P16603 Saccharomyces cerevisiae YHR042W NCP1 NADP-cytochrome P450 reductase involved in ergosterol biosynthesis associated and coordinately regulated with Erg11p ZYRO0G16522g similar to uniprot|Q05541 Saccharomyces cerevisiae YDR288W NSE3 Essential protein of unknown function ZYRO0G16544g similar to Saccharomyces cerevisiae YDR287W inositol monophosphatase and to YHR046C uniprot|P38710 Saccharomyces cerevisiae YHR046C INM1 Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling ZYRO0G16566g similar to uniprot|Q05530 Saccharomyces cerevisiae YDR286C Hypothetical ORF ZYRO0G16588g similar to uniprot|P31111 Saccharomyces cerevisiae YDR285W ZIP1 Synaptonemal complex (SC) protein that connects homologous chromosomes partially during zygotene and entirely during pachytene potential Cdc28p substrate synaptonemal complex protein ZYRO0G16610g similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 Diacylglycerol pyrophosphate (DGPP) phosphatase zinc-regulated vacuolar membrane-associated lipid phosphatase dephosphorylates DGPP to phosphatidate (PA) and Pi then PA to diacylglycerol involved in lipid signaling and cell metabolism ZYRO0G16632g highly similar to uniprot|P15442 Saccharomyces cerevisiae YDR283C GCN2 Protein kinase phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation activated by uncharged tRNAs and the Gcn1p-Gcn20p complex ZYRO0G16654g similar to uniprot|P34162 Saccharomyces cerevisiae YHR041C SRB2 RNA polymerase II holoenzyme/mediator subunit ZYRO0G16676g similar to uniprot|Q05543 Saccharomyces cerevisiae YDR289C RTT103 Regulator of Ty1 Transposition regulator of Ty1 Transposition ZYRO0G16698g highly similar to uniprot|Q05549 Saccharomyces cerevisiae YDR291W Hypothetical ORF ZYRO0G16720g similar to uniprot|P32916 Saccharomyces cerevisiae YDR292C SRP101 Signal recognition particle (SRP) receptor - alpha subunit contain GTPase domains involved in SRP-dependent protein targeting interacts with SRP102p ZYRO0G16742g weakly similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria ZYRO0G16764g similar to uniprot|P38772 Saccharomyces cerevisiae YHR040W BCD1 Essential protein required for the accumulation of box C/D snoRNA ZYRO0G16786g similar to uniprot|P48836 Saccharomyces cerevisiae YHR039C-A VMA10 Vacuolar H+ ATPase subunit G of the catalytic (V1) sector ZYRO0G16808g highly similar to uniprot|P38694 Saccharomyces cerevisiae YHR039C MSC7 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc7 mutants are defective in directing meiotic recombination events to homologous chromatids ZYRO0G16830g similar to uniprot|P38771 Saccharomyces cerevisiae YHR038W RRF1 Ribosomal Recycling Factor 1 originally characterized as FIL1 a Factor for Isocitrate Lyase expression mitochondrial ribosome recycling factor ZYRO0G16852g similar to uniprot|P24276 Saccharomyces cerevisiae YDR293C SSD1 Protein with a role in maintenance of cellular integrity interacts with components of the TOR pathway ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence ZYRO0G16874g highly similar to uniprot|P07275 Saccharomyces cerevisiae YHR037W PUT2 delta-1-pyrroline-5-carboxylate dehydrogenase ZYRO0G16896g similar to uniprot|P38770 Saccharomyces cerevisiae YHR036W Protein required for cell viability ZYRO0G16918g similar to uniprot|Q05567 Saccharomyces cerevisiae YDR294C DPL1 Dihydrosphingosine phosphate lyase regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs) degrades phosphorylated long chain bases prefers C16 dihydrosphingosine-l-phosphate as a substrate ZYRO0G16940g similar to uniprot|Q06629 Saccharomyces cerevisiae YDR295C ZYRO0G16962g weakly similar to uniprot|P38769 Saccharomyces cerevisiae YHR035W Hypothetical ORF ZYRO0G16984g similar to uniprot|Q06630 Saccharomyces cerevisiae YDR296W MHR1 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus binds to activation domains of acidic activators required for recombination-dependent mtDNA partitioning ZYRO0G17006g similar to uniprot|P38992 Saccharomyces cerevisiae YDR297W SUR2 Sphingosine hydroxylase has a role in sphingolipid metabolism catalyses the conversion of sphinganine to phytosphingosine ZYRO0G17028g similar to uniprot|P09457 Saccharomyces cerevisiae YDR298C ATP5 Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein) ZYRO0G17050g similar to uniprot|P42949 Saccharomyces cerevisiae YJL104W ZYRO0G17072g similar to uniprot|P36124 Saccharomyces cerevisiae YKR029C SET3 ZYRO0G17094g similar to uniprot|P32581 Saccharomyces cerevisiae YJL106W IME2 Serine/threonine protein kinase involved in activation of meiosis associates with Ime1p and mediates its stability activates Ndt80p IME2 expression is positively regulated by Ime1p ZYRO0G17116g some similarities with uniprot|P42946 Saccharomyces cerevisiae YJL108C PRM10 Pheromone-regulated protein predicted to have 5 transmembrane segments ZYRO0G17138g similar to uniprot|P42945 Saccharomyces cerevisiae YJL109C UTP10 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0G17160g similar to uniprot|P47128 Saccharomyces cerevisiae YJR082C EAF6 Esa1p-associated factor subunit of the NuA4 acetyltransferase complex ZYRO0G17182g similar to uniprot|Q12406 Saccharomyces cerevisiae YPR034W ARP7 Actin-related protein involved in transcriptional regulation subunit of the chromatin remodeling Snf/Swi complex ZYRO0G17204g highly similar to uniprot|P32288 Saccharomyces cerevisiae YPR035W GLN1 Glutamine synthetase (GS) synthesizes glutamine from glutamate and ammonia with Glt1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source and by amino acid limitation ZYRO0G17226g similar to uniprot|P41807 Saccharomyces cerevisiae YPR036W VMA13 vacuolar ATPase V1 domain subunit H (54 kDa) ZYRO0G17248g weakly similar to uniprot|P47130 Saccharomyces cerevisiae YJR084W CSN12 Subunit of the Cop9 signalosome which is required for deneddylation or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin) involved in adaptation to pheromone signaling ZYRO0G17270g highly similar to uniprot|P47131 Saccharomyces cerevisiae YJR085C Hypothetical ORF ZYRO0G17292g similar to uniprot|P18852 Saccharomyces cerevisiae YJR086W STE18 G protein gamma subunit forms a dimer with Ste4p to activate the mating signaling pathway forms a heterotrimer with Gpa1p and Ste4p to dampen signaling C-terminus is palmitoylated and farnesylated which are required for normal signaling ZYRO0G17314g similar to uniprot|Q12284 Saccharomyces cerevisiae YPR037C ERV2 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen involved in disulfide bond formation within the ER ZYRO0G17336g similar to uniprot|Q12199 Saccharomyces cerevisiae YPR040W TIP41 Protein involved in regulation of the TOR pathway ZYRO0G17358g similar to uniprot|P47133 Saccharomyces cerevisiae YJR088C Hypothetical ORF ZYRO0G17380g highly similar to uniprot|P38431 Saccharomyces cerevisiae YPR041W TIF5 eIF5 mediates hydrolysis of eIF2-GTP (SUI2 SUI3 GCD11) at start codons Translation initiation factor eIF-5 ZYRO0G17424g similar to uniprot|P24814 Saccharomyces cerevisiae YJR090C GRR1 F-box protein component of the SCF ubiquitin-ligase complex required for Cln1p and Cln2p degradation involved in carbon catabolite repression glucose-dependent divalent cation transport high-affinity glucose transport and morphogenesis ZYRO0G17446g similar to uniprot|P47135 Saccharomyces cerevisiae YJR091C JSN1 Member of the Puf family of RNA-binding proteins and to uniprot|Q12221 Saccharomyces cerevisiae YPR042C PUF2 mRNA binding protein ZYRO0G17468g some similarities with uniprot|P47136 Saccharomyces cerevisiae YJR092W BUD4 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding potential Cdc28p substrate ZYRO0G17490g some similarities with uniprot|P45976 Saccharomyces cerevisiae YJR093C FIP1 Subunit of cleavage polyadenylation factor ZYRO0G17512g similar to uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; DNA-binding transcriptional activator or CHA1 and to YOR337W uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Mutants are defective in Ty1 Enhancer-mediated Activation Ty1 enhancer activator ZYRO0G17534g weakly similar to uniprot|P21190 Saccharomyces cerevisiae YJR094C IME1 Master regulator of meiosis that is active only during meiotic events activates transcription of early meiotic genes through interaction with Ume6p degraded by the 26S proteasome following phosphorylation by Ime2p ZYRO0G17556g weakly similar to uniprot|P49631 Saccharomyces cerevisiae YPR043W RPL43A Protein component of the large (60S) ribosomal subunit ZYRO0G17578g highly similar to uniprot|P33303 Saccharomyces cerevisiae YJR095W SFC1 Mitochondrial succinate-fumarate transporter transports succinate into and fumarate out of the mitochondrion required for ethanol and acetate utilization ZYRO0G17600g highly similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W ZYRO0G17622g similar to uniprot|P35127 Saccharomyces cerevisiae YJR099W YUH1 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin hydrolyzes the peptide bond at the C-terminus of ubiquitin also the major processing enzyme for the ubiquitin-like protein Rub1p ZYRO0G17644g weakly similar to uniprot|Q07109 Saccharomyces cerevisiae YPR045C Hypothetical ORF ZYRO0G17666g similar to uniprot|P47140 Saccharomyces cerevisiae YJR100C Hypothetical ORF ZYRO0G17710g similar to uniprot|P47141 Saccharomyces cerevisiae YJR101W RSM26 Mitochondrial ribosomal protein of the small subunit ZYRO0G17732g similar to uniprot|P47142 Saccharomyces cerevisiae YJR102C VPS25 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome ZYRO0G17754g similar to uniprot|Q12262 Saccharomyces cerevisiae YPR046W MCM16 Protein involved in kinetochore-microtubule mediated chromosome segregation binds to centromere DNA ZYRO0G17776g highly similar to gnl|GLV|CAGL0F04433g Candida glabrata CAGL0F04433g and similar to YBL039C uniprot|P28274 Saccharomyces cerevisiae ZYRO0G17798g highly similar to uniprot|P00445 Saccharomyces cerevisiae YJR104C SOD1 Cu Zn superoxide dismutase some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans ZYRO0G17820g similar to uniprot|P18414 Saccharomyces cerevisiae YBL040C ERD2 Integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum has a role in maintenance of normal levels of ER-resident proteins ZYRO0G17842g highly similar to uniprot|P23724 Saccharomyces cerevisiae YBL041W PRE7 20S proteasome beta-type subunit ZYRO0G17864g similar to uniprot|P38196 YBL042C Saccharomyces cerevisiae FUI1 High affinity uridine permease localized to the plasma membrane not involved in uracil transport ZYRO0G17886g no similarity ZYRO0G17930g similar to uniprot|P07256 Saccharomyces cerevisiae YBL045C COR1 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex) which is a component of the mitochondrial inner membrane electron transport chain ZYRO0G17952g some similarities with uniprot|P38193 Saccharomyces cerevisiae YBL046W Hypothetical ORF ZYRO0G17974g similar to uniprot|P47150 Saccharomyces cerevisiae YJR113C RSM7 Mitochondrial ribosomal protein of the small subunit ZYRO0G17996g weakly similar to uniprot|P34216 Saccharomyces cerevisiae YBL047C EDE1 Key endocytic protein involved in a network of interactions with other endocytic proteins binds membranes in a ubiquitin-dependent manner may also bind ubiquitinated membrane-associated proteins ZYRO0G18018g similar to uniprot|P47149 Saccharomyces cerevisiae YJR112W NNF1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules required for accurate chromosome segregation ZYRO0G18040g similar to uniprot|P47148 Saccharomyces cerevisiae YJR111C Hypothetical ORF ZYRO0G18062g similar to uniprot|P47147 Saccharomyces cerevisiae YJR110W YMR1 Phosphatidylinositol 3-phosphate ZYRO0G18084g similar to uniprot|P38191 Saccharomyces cerevisiae YBL049W MOH1 ZYRO0G18106g highly similar to uniprot|P32602 Saccharomyces cerevisiae YBL050W SEC17 ZYRO0G18128g similar to uniprot|P03965 Saccharomyces cerevisiae YJR109C CPA2 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor ZYRO0G18150g highly similar to gnl|GLV|KLLA0D16412g Kluyveromyces lactis KLLA0D16412g and similar to YJL153C uniprot|P11986 Saccharomyces cerevisiae YJL153C INO1 Inositol 1- phosphate synthase involved in synthesis of inositol phosphates and inositol-containing phospholipids transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p which bind the UASINO DNA element ZYRO0G18172g similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase degrades reactive oxygen species in mitochondria involved in the response to oxidative stress ZYRO0G18194g similar to uniprot|P34110 Saccharomyces cerevisiae YJL154C VPS35 Protein involved in vacuolar sorting retromer complex component ZYRO0G18216g highly similar to uniprot|P32604 Saccharomyces cerevisiae YJL155C FBP26 Fructose-2 6-bisphosphatase required for glucose metabolism ZYRO0G18238g similar to uniprot|P47002 Saccharomyces cerevisiae YJL156C SSY5 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes ZYRO0G18260g similar to uniprot|P21268 Saccharomyces cerevisiae YJL157C FAR1 Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone also forms a complex with Cdc24p Ste4p and Ste18p that may specify the direction of polarized growth during mating potential Cdc28p substrate ZYRO0G18282g some similarities with uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats ZYRO0G18304g similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats ZYRO0G18326g similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats ZYRO0G18348g conserved hypothetical protein ZYRO0G18370g weakly similar to uniprot|P46998 Saccharomyces cerevisiae YJL161W FMP33 The authentic non-tagged protein was localized to the mitochondria ZYRO0G18436g similar to uniprot|Q757X4 Ashbya gossypii AEL112C AEL112Cp and weakly similar to YJL162C uniprot|P46997 Saccharomyces cerevisiae YJL162C JJJ2 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain ZYRO0G18458g highly similar to uniprot|P36051 Saccharomyces cerevisiae YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis multimembrane-spanning protein that localizes to the endoplasmic reticulum highly conserved among eukaryotes ZYRO0G18480g similar to gnl|GLV|CAGL0M08426g Candida glabrata CAGL0M08426g and weakly similar to YJL163C uniprot|P46996 Saccharomyces cerevisiae YJL163C Hypothetical ORF ZYRO0G18502g similar to uniprot|P05986 Saccharomyces cerevisiae YKL166C TPK3 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit and to YJL164C uniprot|P06244 Saccharomyces cerevisiae YJL164C TPK1 putative catalytic subunit of cAMP-dependent protein kinase ZYRO0G18524g similar to uniprot|P32388 Saccharomyces cerevisiae YKL167C MRP49 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation ZYRO0G18546g similar to uniprot|P38970 Saccharomyces cerevisiae YJL165C HAL5 Putative protein kinase overexpression increases sodium and lithium tolerance whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake suggesting a role in regulation of Trk1p and/or Trk2p transporters ZYRO0G18568g highly similar to uniprot|P35996 Saccharomyces cerevisiae YKL170W MRPL38 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels ZYRO0G18590g similar to uniprot|Q757Y0 Ashbya gossypii AEL120W AEL120Wp and weakly similar to YKL171W uniprot|P36003 Saccharomyces cerevisiae YKL171W Hypothetical ORF ZYRO0G18612g highly similar to uniprot|P08525 Saccharomyces cerevisiae YJL166W QCR8 Ubiquinol cytochrome-c reductase subunit 8 ZYRO0G18634g highly similar to uniprot|P08524 Saccharomyces cerevisiae YJL167W ERG20 Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis ZYRO0G18656g highly similar to gnl|GLV|CAGL0L00341g Candida glabrata CAGL0L00341g and highly similar to YKL172W uniprot|P36049 Saccharomyces cerevisiae YKL172W EBP2 Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly localizes to the nucleolus ZYRO0G18678g similar to uniprot|P36048 Saccharomyces cerevisiae YKL173W SNU114 involved in splicing U5 snRNP-specific protein related to EF-2 ZYRO0G18700g similar to uniprot|P36029 Saccharomyces cerevisiae YKL174C TPO5 Protein involved in excretion of putrescine and spermidine putative polyamine transporter in the Golgi or post-Golgi vesicles ZYRO0G18722g similar to uniprot|P34240 Saccharomyces cerevisiae YKL175W ZRT3 Vacuolar membrane zinc transporter transports zinc from storage in the vacuole to the cytoplasm when needed transcription is induced under conditions of zinc deficiency ZYRO0G18744g similar to uniprot|P34239 Saccharomyces cerevisiae YKL176C LST4 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface ZYRO0G18766g similar to uniprot|P46995 Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation methylates a lysine residue of histone H3 associates with the C-terminal domain of Rpo21p histone methylation activity is regulated by phosphorylation status of Rpo21p ZYRO0G18788g weakly similar to uniprot|P46993 Saccharomyces cerevisiae YJL170C ASG7 Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell specific to a-cells and induced by alpha-factor ZYRO0G18810g similar to uniprot|P06783 Saccharomyces cerevisiae YKL178C STE3 Cell surface a factor receptor transcribed in alpha cells and required for mating by alpha cells couples to MAP kinase cascade to mediate pheromone response ligand bound receptors undergo endocytosis and recycling to the plasma membrane ZYRO0G18832g similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions ZYRO0G18854g highly similar to gnl|GLV|CAGL0C00341g Candida glabrata CAGL0C00341g and similar to YJL173C uniprot|P26755 Saccharomyces cerevisiae YJL173C RFA3 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination ZYRO0G18876g highly similar to uniprot|Q08911 Saccharomyces cerevisiae YOR388C FDH1 NAD()-dependent formate dehydrogenase may protect cells from exogenous formate ZYRO0G18898g similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta-glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects ZYRO0G18920g highly similar to uniprot|P39940 Saccharomyces cerevisiae YER125W RSP5 Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation plays a role in heat shock element (HSE)-mediated gene expression and multivesicular body sorting contains a hect (homologous to E6-AP carboxyl terminus) domain ZYRO0G18942g weakly similar to uniprot|P46945 Saccharomyces cerevisiae YGL176C Hypothetical ORF ZYRO0G18964g similar to uniprot|P39016 Saccharomyces cerevisiae YGL178W MPT5 Protein that specifically binds to mRNAs encoding chromatin modifiers and spindle pole body components has roles in longevity in maintenance of cell wall integrity and in sensitivity to and recovery from pheromone arrest ZYRO0G18986g highly similar to uniprot|P40078 Saccharomyces cerevisiae YER126C NSA2 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis ZYRO0G19008g similar to uniprot|P40079 Saccharomyces cerevisiae YER127W LCP5 Essential protein involved in maturation of 18S rRNA depletion leads to inhibited pre-rRNA processing and reduced polysome levels localizes primarily to the nucleolus ZYRO0G19030g similar to uniprot|P40080 Saccharomyces cerevisiae YER128W Hypothetical ORF ZYRO0G19052g similar to uniprot|P38990 Saccharomyces cerevisiae YER129W PAK1 Upstream kinase for the SNF1 complex partially redundant function with Elm1p and Tos3p members of this family of kinases have functional orthology with LKB1 a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome and some similarities with YGL179C uniprot|P43637 Saccharomyces cerevisiae YGL179C TOS3 Putative protein kinase, related to and redundant with Elm1p and Pak1p in activating the SNF1 complex ZYRO0G19074g similar to uniprot|P53104 Saccharomyces cerevisiae YGL180W ATG1 Protein serine/threonine kinase required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway ZYRO0G19096g weakly similar to uniprot|P40956 Saccharomyces cerevisiae YGL181W GTS1 Contains a zinc-finger in the N-terminus and a long Gln-rich region in the C-terminus regulates ultradian rhythm cell size cell cycle lifespan sporulation heat tolerance and multidrug transport ZYRO0G19118g similar to uniprot|P53102 Saccharomyces cerevisiae YGL183C MND1 Protein required for recombination and meiotic nuclear division forms a complex with Hop2p which is involved in chromosome pairing and repair of meiotic double-strand breaks ZYRO0G19140g weakly similar to uniprot|P39959 Saccharomyces cerevisiae YER130C Hypothetical ORF ZYRO0G19162g similar to uniprot|P53101 Saccharomyces cerevisiae YGL184C STR3 Cystathionine beta-lyase converts cystathionine into homocysteine ZYRO0G19184g similar to uniprot|P53100 Saccharomyces cerevisiae YGL185C Putative hydroxyacid dehydrogenase ZYRO0G19206g similar to uniprot|P04037 Saccharomyces cerevisiae YGL187C COX4 Subunit IV of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain N-terminal 25 residues of precursor are cleaved during mitochondrial import ZYRO0G19228g highly similar to uniprot|P39938 Saccharomyces cerevisiae YGL189C ZYRO0G19250g highly similar to uniprot|Q00362 Saccharomyces cerevisiae YGL190C CDC55 Non-essential regulatory subunit B of protein phosphatase 2A has multiple roles in mitosis and protein biosynthesis found in the nucleus of most cells but also at the bud neck (large-budded cells) and at the bud tip (small-budded cells) ZYRO0G19272g highly similar to uniprot|P32799 Saccharomyces cerevisiae YGL191W COX13 Subunit VIa of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain not essential for cytochrome c oxidase activity but may modulate activity in response to ATP ZYRO0G19294g similar to uniprot|P41833 Saccharomyces cerevisiae YGL192W IME4 Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation expression is induced in starved MATa/MAT alpha diploid cells ZYRO0G19316g highly similar to uniprot|P53096 Saccharomyces cerevisiae YGL194C HOS2 Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails subunit of the Set3 complex a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity ZYRO0G19338g similar to uniprot|Q754A1 Ashbya gossypii AFR171W AFR171Wp and some similarites with YDR034C uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co-inducer ZYRO0G19360g similar to uniprot|P33892 Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn20p proposed to stimulate Gcn2p activation by an uncharged tRNA ZYRO0G19404g similar to uniprot|P53095 Saccharomyces cerevisiae YGL196W Hypothetical ORF ZYRO0G19426g weakly similar to uniprot|P53094 Saccharomyces cerevisiae YGL197W MDS3 Protein with an N-terminal kelch-like domain putative negative regulator of early meiotic gene expression required with Pmd1p for growth under alkaline conditions ZYRO0G19448g similar to uniprot|P53093 Saccharomyces cerevisiae YGL198W YIP4 Protein that interacts with Rab GTPases computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport ZYRO0G19492g highly similar to uniprot|P32598 Saccharomyces cerevisiae YER133W GLC7 Catalytic subunit of type 1 serine/threonine protein phosphatase involved in many processes including glycogen metabolism sporulation and mitosis interacts with multiple regulatory subunits predominantly isolated with Sds22p ZYRO0G19514g highly similar to uniprot|P32803 Saccharomyces cerevisiae YGL200C EMP24 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport ZYRO0G19580g weakly similar to uniprot|P53286 Saccharomyces cerevisiae YGR142W BTN2 Cytosolic coiled-coil protein that modulates arginine uptake interacts with Rhb1p possible role in mediating pH homeostasis between the vacuole and plasma membrane H()-ATPase may have a role in intracellular protein trafficking ZYRO0G19602g similar to uniprot|P53285 Saccharomyces cerevisiae YGR141W VPS62 and similar to uniprot|Q06466 Saccharomyces cerevisiae YPR157W Hypothetical ORF ZYRO0G19624g similar to uniprot|Q753I9 Ashbya gossypii AFR323W AFR323Wp and weakly similar to YGR140W uniprot|P32504 Saccharomyces cerevisiae YGR140W CBF2 Essential kinetochore protein component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere Cbf2p also binds to the CDEII region possibly forming a different multimeric complex ubiquitinated in vivo ZYRO0G19646g similar to uniprot|P53283 Saccharomyces cerevisiae YGR138C TPO2 Polyamine transport protein ZYRO0G19690g weakly similar to uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization ZYRO0G19712g weakly similar to uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization ZYRO0G19734g weakly similar to uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization ZYRO0G19756g weakly similar to uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization ZYRO0G19778g similar to uniprot|P34246 Saccharomyces cerevisiae YKL098W Hypothetical ORF ZYRO0G19800g similar to uniprot|P34247 Saccharomyces cerevisiae YKL099C UTP11 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA ZYRO0G19822g weakly similar to uniprot|P34248 Saccharomyces cerevisiae YKL100C Hypothetical ORF ZYRO0G19844g highly similar to uniprot|Q08920 Saccharomyces cerevisiae YPL178W CBC2 Small subunit of the heterodimeric cap binding complex that also contains Sto1p component of the spliceosomal commitment complex interacts with Npl3p possibly to package mRNA for export from the nucleus contains an RNA-binding motif ZYRO0G19866g highly similar to uniprot|Q08911 Saccharomyces cerevisiae YOR388C FDH1 NAD()-dependent formate dehydrogenase may protect cells from exogenous formate ZYRO0G19888g similar to uniprot|P37297 Saccharomyces cerevisiae YLR305C STT4 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway required for normal vacuole morphology cell wall integrity and actin cytoskeleton organization ZYRO0G19910g similar to uniprot|P52491 Saccharomyces cerevisiae YLR306W UBC12 Enzyme that mediates the conjugation of Rub1p a ubiquitin-like protein to other proteins related to E2 ubiquitin-conjugating enzymes ZYRO0G19932g similar to uniprot|Q04438 Saccharomyces cerevisiae YMR107W ZYRO0G19954g highly similar to uniprot|P07342 Saccharomyces cerevisiae YMR108W ILV2 Acetolactate synthase catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors localizes to the mitochondria expression of the gene is under general amino acid control ZYRO0G19976g similar to uniprot|Q04439 Saccharomyces cerevisiae YMR109W MYO5 One of two type I myosins contains proline-rich tail homology 2 (TH2) and SH3 domains MYO5 deletion has little effect on growth but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization and to uniprot|P36006 Saccharomyces cerevisiae YKL129C MYO3 ZYRO0G19998g similar to uniprot|P36068 Saccharomyces cerevisiae YKL130C SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud ZYRO0G20020g weakly similar to uniprot|Q04461 Saccharomyces cerevisiae YMR111C Hypothetical ORF ZYRO0G20042g similar to uniprot|Q99278 Saccharomyces cerevisiae YMR112C MED11 14 Kd mediator subunit of RNA polymerase II holoenzyme ZYRO0G20064g similar to uniprot|Q12676 Saccharomyces cerevisiae YMR113W FOL3 Dihydrofolate synthetase involved in folic acid biosynthesis catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis ZYRO0G20086g similar to uniprot|Q04471 Saccharomyces cerevisiae YMR114C Hypothetical ORF ZYRO0G20108g similar to uniprot|Q04472 Saccharomyces cerevisiae YMR115W FMP24 The authentic non-tagged protein was localized to the mitochondria ZYRO0G20130g similar to uniprot|P35999 Saccharomyces cerevisiae YKL134C OCT1 Mitochondrial intermediate peptidase cleaves N-terminal residues of a subset of proteins upon import after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p) may contribute to mitochondrial iron homeostasis ZYRO0G20152g highly similar to uniprot|P38011 Saccharomyces cerevisiae YMR116C ASC1 WD repeat protein (G-beta like protein) involved in translation regulation required for repression of Gcn4p activity in the absence of amino-acid starvation core component of the ribosome ortholog of mammalian RACK1 ZYRO0G20196g highly similar to uniprot|P36000 Saccharomyces cerevisiae YKL135C APL2 Beta-adaptin large subunit of the clathrin-associated protein (AP-1) complex ZYRO0G20218g similar to uniprot|P36064 Saccharomyces cerevisiae YKL137W Hypothetical ORF ZYRO0G20240g similar to uniprot|P14063 Saccharomyces cerevisiae YKL138C MRPL31 Mitochondrial ribosomal protein of the large subunit ZYRO0G20262g similar to uniprot|Q04477 Saccharomyces cerevisiae YMR117C SPC24 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering ZYRO0G20284g highly similar to YKL138c-a ZYRO0G20306g similar to uniprot|Q03957 Saccharomyces cerevisiae YKL139W CTK1 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C- terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing ZYRO0G20328g similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase one of three gene products (Yeh1p Yeh2p Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis localized to lipid particle membranes ZYRO0G20350g similar to uniprot|P33421 Saccharomyces cerevisiae YKL141W SDH3 Cytochrome b subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone and some similarites with YMR118C uniprot|Q04487 Saccharomyces cerevisiae YMR118C Hypothetical ORF, member of GLR.231 ZYRO0G20372g weakly similar to uniprot|Q06449 Saccharomyces cerevisiae YPR154W PIN3 Protein that induces appearance of [PIN ] prion when overproduced ZYRO0G20394g conserved hypothetical protein ZYRO0G20416g similar to uniprot|P39929 Saccharomyces cerevisiae YLR025W SNF7 Involved in derepression of SUC2 in response to glucose limitation involved in glucose derepression ZYRO0G20438g similar to uniprot|Q01590 Saccharomyces cerevisiae YLR026C SED5 Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport ZYRO0G20460g some similarities with uniprot|P47045 Saccharomyces cerevisiae YJL054W TIM54 Translocase Inner Membrane 54kD Translocase for the insertion of proteins into the mitochondrial inner membrane. ZYRO0G20482g similar to uniprot|P47044 Saccharomyces cerevisiae YJL055W Hypothetical ORF ZYRO0G20504g similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance ZYRO0G20526g weakly similar to uniprot|P47043 Saccharomyces cerevisiae YJL056C ZAP1 Zinc-regulated transcription factor binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc regulates its own transcription contains seven zinc- finger domains ZYRO0G20548g similar to uniprot|P38347 YBR271W Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family ZYRO0G20570g similar to uniprot|P47042 Saccharomyces cerevisiae YJL057C probable serine/threonine kinase ZYRO0G20592g similar to uniprot|P38346 Saccharomyces cerevisiae YBR270C BIT2 Hypothetical ORF ZYRO0G20614g similar to uniprot|P47040 Saccharomyces cerevisiae YJL059W YHC3 Homolog of human CLN3 vacuolar/lysosomal membrane protein ZYRO0G20636g highly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Arylformamidase involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway potential Cdc28p substrate ZYRO0G20658g similar to uniprot|P38345 Saccharomyces cerevisiae YBR269C FMP21 The authentic non-tagged protein was localized to the mitochondria ZYRO0G20680g similar to uniprot|P40368 Saccharomyces cerevisiae YJL061W NUP82 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup159p and Nsp1p interacts with Nup116p and is required for proper localization of Nup116p in the NPC ZYRO0G20702g similar to uniprot|P36532 Saccharomyces cerevisiae YBR268W MRPL37 Mitochondrial ribosomal protein of the large subunit ZYRO0G20724g similar to uniprot|P40367 Saccharomyces cerevisiae YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure mutations affect cell wall integrity ZYRO0G20746g similar to uniprot|P38344 Saccharomyces cerevisiae YBR267W REI1 Protein of unknown function involved in bud growth in the mitotic signaling network proposed negative regulator of Swe1p and Gin4p contains dispersed C2H2 zinc finger domains ZYRO0G20768g similar to uniprot|P38342 Saccharomyces cerevisiae YBR265W TSC10 catalyzes the second step in the synthesis of phytosphingosine 3-ketosphinganine reductase ZYRO0G20790g similar to uniprot|Q3E7B2 Saccharomyces cerevisiae YJL062W-A Hypothetical ORF ZYRO0G20812g similar to uniprot|P22353 Saccharomyces cerevisiae YJL063C MRPL8 Mitochondrial ribosomal protein of the large subunit ZYRO0G20834g similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF ZYRO0G20856g similar to uniprot|P38148 Saccharomyces cerevisiae YBR276C PPS1 Protein phosphatase with specificity for serine threonine and tyrosine residues has a role in the DNA synthesis phase of the cell cycle ZYRO0G20878g similar to gnl|GLV|KLLA0F01859g Kluyveromyces lactis KLLA0F01859g and some similarites with YBR278W uniprot|P27344 Saccharomyces cerevisiae YBR278W DPB3 Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing mRNA abundance peaks at the G1/S boundary of the cell cycle ZYRO0G20900g similar to gnl|GLV|KLLA0F01881g Kluyveromyces lactis KLLA0F01881g and weakly similar to YJL066C uniprot|P40364 Saccharomyces cerevisiae YJL066C MPM1 Mitochondrial membrane protein of unknown function contains no hydrophobic stretches ZYRO0G20922g similar to uniprot|P38351 Saccharomyces cerevisiae YBR279W PAF1 RNA polymerase II-associated protein defines a large complex that is biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme and is required for full expression of a subset of cell cycle-regulated genes ZYRO0G20944g similar to uniprot|P40363 Saccharomyces cerevisiae YJL068C Hypothetical ORF ZYRO0G20966g similar to uniprot|P38352 Saccharomyces cerevisiae YBR280C Hypothetical ORF ZYRO0G20988g similar to uniprot|P38149 Saccharomyces cerevisiae YBR281C Hypothetical ORF ZYRO0G21010g similar to uniprot|P40362 Saccharomyces cerevisiae YJL069C UTP18 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data ZYRO0G21032g no similarity ZYRO0G21054g highly similar to gnl|GLV|CAGL0B03267g Candida glabrata CAGL0B03267g and similar to YBR282W uniprot|P36526 Saccharomyces cerevisiae YBR282W MRPL27 Mitochondrial ribosomal protein of the large subunit ZYRO0G21076g highly similar to uniprot|P38353 Saccharomyces cerevisiae YBR283C SSH1 Subunit of the Ssh1 translocon complex Sec61p homolog involved in co-translational pathway of protein translocation not essential ZYRO0G21120g similar to uniprot|P40361 Saccharomyces cerevisiae YJL070C and to uniprot|P38150 Saccharomyces cerevisiae YBR284W Hypothetical ORFs ZYRO0G21142g similar to uniprot|P40360 Saccharomyces cerevisiae YJL071W ARG2 Acetylglutamate synthase (glutamate N-acetyltransferase) mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine forms a complex with Arg5 6p ZYRO0G21164g highly similar to uniprot|P40359 Saccharomyces cerevisiae YJL072C PSF2 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery ZYRO0G21186g highly similar to uniprot|P40359 Saccharomyces cerevisiae YJL072C ZYRO0G21208g similar to uniprot|P37302 Saccharomyces cerevisiae YBR286W APE3 Vacuolar aminopeptidase Y processed to mature form by Prb1p ZYRO0G21230g weakly similar to uniprot|P40358 Saccharomyces cerevisiae YJL073W JEM1 DnaJ-like chaperone required for nuclear membrane fusion during mating localizes to the ER membrane exhibits genetic interactions with KAR2 ZYRO0G21252g similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1 ZYRO0G21296g similar to uniprot|P47037 Saccharomyces cerevisiae YJL074C SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells also required with Rec8p for cohesion and recombination during meiosis phylogenetically conserved SMC chromosomal ATPase family member ZYRO0G21318g some similarities with uniprot|P47035 Saccharomyces cerevisiae YJL076W NET1 Core subunit of the RENT complex which is a complex involved in nucleolar silencing and telophase exit stimulates transcription by RNA polymerase I and regulates nucleolar structure ZYRO0G21340g some similarities with uniprot|P36110 Saccharomyces cerevisiae YKR013W PRY2 Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins ZYRO0G21362g similar to uniprot|P06105 Saccharomyces cerevisiae YJL080C SCP160 May be required during cell division for faithful partitioning of the ER-nuclear envelope membranes involved in control of mitotic chromosome transmission ZYRO0G21384g highly similar to uniprot|Q75F92 Ashbya gossypii AAL176C AAL176Cp and similar to YKR014C uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis probable purine nucleotide-binding protein ZYRO0G21406g similar to uniprot|P36112 Saccharomyces cerevisiae YKR016W FMP13 The authentic non-tagged protein was localized to the mitochondria ZYRO0G21428g highly similar to uniprot|P80428 Saccharomyces cerevisiae YJL081C ARP4 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes ZYRO0G21450g similar to uniprot|P36113 Saccharomyces cerevisiae YKR017C Hypothetical ORF ZYRO0G21472g highly similar to uniprot|P36114 Saccharomyces cerevisiae YKR018C Hypothetical ORF ZYRO0G21494g weakly similar to YJL083W, uniprot|P47030 Saccharomyces cerevisiae YJL083W (TAX4) ZYRO0G21516g similar to uniprot|P36116 Saccharomyces cerevisiae YKR020W VPS51 whiskey (whi) mutant forms a tetramer with VPS52 VPS53 and VPS54 ZYRO0G21538g conserved hypothetical protein ZYRO0G21560g highly similar to gnl|GLV|CAGL0F07491g Candida glabrata CAGL0F07491g and similar to uniprot|P53141 Saccharomyces cerevisiae YGL106W MLC1 Essential light chain for myosin Myo2p may stabilize Myo2p by binding to the neck region may interact with Myo1p Iqg1p and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition ZYRO0G21582g similar to uniprot|P38140 Saccharomyces cerevisiae YBR239C Hypothetical ORF ZYRO0G21604g similar to uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids ZYRO0G21626g weakly similar to uniprot|P38141 Saccharomyces cerevisiae YBR240C THI2 Zinc finger protein of the Zn(II)2Cys6 type probable transcriptional activator of thiamine biosynthetic genes ZYRO0G21648g similar to uniprot|P38142 Saccharomyces cerevisiae YBR241C Hypothetical ORF ZYRO0G21670g highly similar to uniprot|P02406 Saccharomyces cerevisiae YGL103W RPL28 Ribosomal protein L29 of the large (60S) ribosomal subunit ZYRO0G21692g highly similar to gnl|GLV|CAGL0J10362g Candida glabrata CAGL0J10362g and similar to YBR242W uniprot|P38331 Saccharomyces cerevisiae YBR242W Hypothetical ORF or YGL101W uniprot|P53144 Saccharomyces cerevisiae YGL101W Hypothetical ORF ZYRO0G21714g highly similar to uniprot|P07286 Saccharomyces cerevisiae YBR243C ALG7 UDP-N-acetyl-glucosamine-1-P transferase transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation inhibited by tunicamycin ZYRO0G21736g highly similar to uniprot|P53011 Saccharomyces cerevisiae YGL100W SEH1 Nuclear pore protein homologous to Sec13p ZYRO0G21758g highly similar to uniprot|P40581 Saccharomyces cerevisiae YIR037W HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor or YBR244W uniprot|P38143 Saccharomyces cerevisiae YBR244W GPX2 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress ZYRO0G21780g similar to uniprot|P38144 Saccharomyces cerevisiae YBR245C ISW1 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation and a complex with Ioc3p to repress transcription initiation ZYRO0G21802g similar to uniprot|P38332 Saccharomyces cerevisiae YBR246W Hypothetical ORF ZYRO0G21824g similar to uniprot|P53145 Saccharomyces cerevisiae YGL099W LSG1 Putative GTPase involved in 60S ribosomal subunit biogenesis localized to the cytoplasm ZYRO0G21846g similar to uniprot|P53146 Saccharomyces cerevisiae YGL098W USE1 Use1p is a SNARE and forms a complex with the SNAREs Sec22p Sec20p and Ufe1p. The protein is localized to the ER and use1 mutants show defects in retrograde traffic from the Golgi to the ER Protein required for cell viability ZYRO0G21868g weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane ZYRO0G21890g weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane ZYRO0G21912g similar to uniprot|P38333 Saccharomyces cerevisiae YBR247C ENP1 Protein associated with U3 and U14 snoRNAs required for pre-rRNA processing and 40S ribosomal subunit synthesis localized in the nucleus and concentrated in the nucleolus ZYRO0G21934g no similarity ZYRO0G21956g highly similar to uniprot|P21827 Saccharomyces cerevisiae YGL097W SRM1 Nucleotide exchange factor for Gsp1p localizes to the nucleus required for nucleocytoplasmic trafficking of macromolecules potentially phosphorylated by Cdc28p ZYRO0G21978g highly similar to uniprot|P33734 Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase) catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR) a purine precursor ZYRO0G22000g highly similar to uniprot|P32449 Saccharomyces cerevisiae YBR249C ARO4 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase ZYRO0G22022g weakly similar to uniprot|P33757 Saccharomyces cerevisiae YBR250W Hypothetical ORF ZYRO0G22044g some similarities with uniprot|P41817 Saccharomyces cerevisiae YPL177C CUP9 Homeodomain-containing transcriptional repressor of PTR2 which encodes a major peptide transporter imported peptides activate ubiquitin-dependent proteolysis resulting in degradation of Cup9p and de-repression of PTR2 transcription ZYRO0G22110g no similarity ZYRO0G22132g no similarity ZYRO0G22154g highly similar to uniprot|P19414 Saccharomyces cerevisiae YLR304C ACO1 Mitochondrial aconitase required for the tricarboxylic acid (TCA) cycle mutation leads to glutamate auxotrophy ZYRO0G22176g similar to uniprot|P14772 Saccharomyces cerevisiae YLL015W BPT1 ABC type transmembrane transporter of MRP/CFTR family found in vacuolar membrane involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates along with Ycf1p ZYRO0G22198g highly similar to uniprot|P06106 Saccharomyces cerevisiae YLR303W MET17 O-acetyl homoserine-O-acetyl serine sulfhydrylase required for sulfur amino acid synthesis ZYRO0G22264g highly similar to uniprot|P53290 Saccharomyces cerevisiae YGR163W GTR2 Cytoplasmic GTP binding protein functions as a negative regulator of the Ran/Tc4 GTPase cycle downstream of its binding partner and homolog Gtr1p homolog of human RagC and RagD proteins ZYRO0G22286g similar to uniprot|P53177 Saccharomyces cerevisiae YGL050W Hypothetical ORF ZYRO0G22308g some similarities with uniprot|P39935 Saccharomyces cerevisiae YGR162W TIF4631 also called eIF4 (eIF-4) gamma mRNA cap-binding protein (eIF-4F) 150K subunit highly homologous to Tif4632p homologs of mammalian p220 ZYRO0G22330g highly similar to uniprot|Q01939 Saccharomyces cerevisiae YGL048C RPT6 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates bound by ubiquitin-protein ligases Ubr1p and Ufd4p localized mainly to the nucleus throughout the cell cycle ZYRO0G22352g similar to uniprot|P53178 Saccharomyces cerevisiae YGL047W ZYRO0G22374g similar to uniprot|P15992 Saccharomyces cerevisiae YBR072W HSP26 Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer induced by heat upon entry into stationary phase and during sporulation ZYRO0G22396g conserved hypothetical protein ZYRO0G22418g similar to uniprot|P05066 Saccharomyces cerevisiae YOR386W PHR1 DNA photolyase involved in photoreactivation repairs pyrimidine dimers in the presence of visible light induced by DNA damage regulated by transcriptional repressor Rph1p ZYRO0G22440g conserved hypothetical protein ZYRO0G22462g similar to uniprot|P06115 Saccharomyces cerevisiae YGR088W CTT1 Cytosolic catalase T has a role in protection from oxidative damage by hydrogen peroxide ZYRO0G22484g similar to uniprot|O59822 Schizosaccharomyces pombe SPCC1840 SPCC965.02 protein and weakly similar to YJL212C uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family ZYRO0G22506g similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W ZYRO0G22528g similar to uniprot|P53047 Saccharomyces cerevisiae YGR213C RTA1 involved in 7-aminocholesterol resistance ZYRO0G22550g weakly similar to uniprot|P39961 Saccharomyces cerevisiae YER184C Hypothetical ORF ZYRO0G22572g similar to uniprot|Q2US70 Aspergillus oryzae AO090005000547 Predicted protein