-- dump date   	20240507_090050
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
AWJ20_1	Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2	Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17218313]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 8335627]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IDA,IMP] [PMID 17218313]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 17218313]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0015204 - urea transmembrane transporter activity [Evidence IMP,ISS] [PMID 8335627]; GO_process: GO:0015847 - putrescine transport [Evidence IDA,IMP] [PMID 17218313]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 17218313]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IEP] [PMID 8335627]; GO_process: GO:0015840 - urea transport [Evidence IMP,ISS] [PMID 8335627]
AWJ20_4	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 17684230]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 15215336]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_5	General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9334234]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 6985606]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 8876173]; GO_function: GO:0001012 - RNA polymerase II regulatory region DNA binding [Evidence IDA] [PMID 15767671]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IMP] [PMID 15767671]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 12692127]; GO_process: GO:0006379 - mRNA cleavage [Evidence IMP] [PMID 9712888]; GO_process: GO:0001193 - maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14531857]; GO_process: GO:0001193 - maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 16492753]; GO_process: GO:0001193 - maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 17535246]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA,IMP] [PMID 17913884]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 8876173]; GO_process: GO:0032784 - regulation of DNA-templated transcription, elongation [Evidence IEA]; GO_process: GO:0031440 - regulation of mRNA 3'-end processing [Evidence IGI,IMP] [PMID 15531585]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 18628399]; GO_process: GO:0031564 - transcription antitermination [Evidence IDA] [PMID 8636112]; GO_process: GO:0031564 - transcription antitermination [Evidence IDA] [PMID 9037112]; GO_process: GO:0031564 - transcription antitermination [Evidence IDA] [PMID 9169440]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 7002153]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 7002153]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 7020755]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 8288647]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 9334234]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IDA] [PMID 18628399]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IMP] [PMID 15767671]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA,IGI,IMP] [PMID 17901206]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_7	Central component of the peroxisomal protein import machinery; peroxisomal membrane peroxin; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA,IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 9094717]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 9312008]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 9094717]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 9312008]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IEA]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IMP,IPI] [PMID 16107331]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 9094717]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 9312008]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_10	Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,ISS] [PMID 10681558]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10821871]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA,IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP,ISS] [PMID 10681558]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA] [PMID 10821871]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 10681558]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0046686 - response to cadmium ion [Evidence IMP] [PMID 19332553]
AWJ20_11	Fungal Genetics Stock Center 12450; Fungal Genetics Stock Center 12449
AWJ20_12	Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15470103]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8909536]; GO_component: GO:0045009 - chitosome [Evidence IDA] [PMID 8970154]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9008706]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9008706]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 15755916]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IMP] [PMID 9760183]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 1293886]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence TAS] [PMID 7565410]
AWJ20_13	Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15470103]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8909536]; GO_component: GO:0045009 - chitosome [Evidence IDA] [PMID 8970154]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9008706]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9008706]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 15755916]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IMP] [PMID 9760183]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 1293886]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence TAS] [PMID 7565410]
AWJ20_14	Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15210724]; GO_component: GO:0000502 - proteasome complex [Evidence IEA,IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence TAS] [PMID 8982460]; GO_function: GO:0004175 - endopeptidase activity [Evidence TAS] [PMID 9697412]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 12198498]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 12200120]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0042176 - regulation of protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
AWJ20_15	Fungal Genetics Stock Center 13879
AWJ20_16	Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 2647766]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0008239 - dipeptidyl-peptidase activity [Evidence IDA] [PMID 2647766]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA,IEA]; GO_process: GO:0016485 - protein processing [Evidence ISS] [PMID 3305478]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_17	Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, cell cycle progression, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to phagophore assembly site (PAS); plays a role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway; SLT2 has a paralog, KDX1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12361575]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 23924898]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 23924898]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12361575]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23924898]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence ISS] [PMID 8386319]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 20823268]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 24554767]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000165 - MAPK cascade [Evidence IEA,IEA]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 18971375]; GO_process: GO:0000917 - barrier septum assembly [Evidence IGI] [PMID 19633265]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IDA,IMP] [PMID 16380504]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IGI] [PMID 16524906]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 14703512]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 20219973]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 8386319]; GO_process: GO:0042990 - regulation of transcription factor import into nucleus [Evidence IMP] [PMID 20219973]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16087742]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 8386319]
AWJ20_18	RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IPI] [PMID 11486042]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IPI] [PMID 11486042]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IPI] [PMID 11486042]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IGI] [PMID 9927738]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_20	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_22	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_23	Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
AWJ20_24	Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 8841414]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8841414]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0050203 - oxalate-CoA ligase activity [Evidence IDA,IMP] [PMID 24291261]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0033611 - oxalate catabolic process [Evidence IDA,IMP] [PMID 24291261]
AWJ20_25	Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9012791]; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720285]; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 8430095]
AWJ20_26	Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10775416]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10775416]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004326 - tetrahydrofolylpolyglutamate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004326 - tetrahydrofolylpolyglutamate synthase activity [Evidence IDA] [PMID 10775416]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IMP] [PMID 10775416]; GO_process: GO:0046901 - tetrahydrofolylpolyglutamate biosynthetic process [Evidence IEA]
AWJ20_27	Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12206772]; GO_function: GO:0017005 - 3'-tyrosyl-DNA phosphodiesterase activity [Evidence IDA] [PMID 10521354]; GO_function: GO:0070260 - 5'-tyrosyl-DNA phosphodiesterase activity [Evidence IDA] [PMID 16751265]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 10521354]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15135727]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_28	Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12097146]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12097146]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 12097146]; GO_function: GO:0005543 - phospholipid binding [Evidence IDA] [PMID 12097146]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI] [PMID 17417630]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IGI] [PMID 16615892]
AWJ20_29	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 8895471]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP] [PMID 16481473]
AWJ20_30	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI] [PMID 20681974]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 18178563]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 18178563]; GO_process: GO:0007034 - vacuolar transport [Evidence IGI] [PMID 20526336]
AWJ20_32	NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11921099]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IGI,ISS] [PMID 11921099]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 21246355]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 11921099]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 19564482]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_33	NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11921099]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IGI,ISS] [PMID 11921099]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 21246355]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 11921099]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 19564482]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_34	D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IDA] [PMID 17869212]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IDA] [PMID 17937657]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0070178 - D-serine metabolic process [Evidence IMP] [PMID 17937657]
AWJ20_35	TFIID subunit (65 kDa); involved in RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_36	D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9525904]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IMP,ISS] [PMID 8492799]; GO_function: GO:0008762 - UDP-N-acetylmuramate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8492799]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_37	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 8070654]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP,IPI] [PMID 11805328]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15167887]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IGI] [PMID 8070654]
AWJ20_39	Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein; GO_component: GO:0030690 - Noc1p-Noc2p complex [Evidence IPI] [PMID 11371346]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23209026]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 9786894]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 23209026]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_41	Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 8314797]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20681974]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI,IMP] [PMID 20681974]; GO_process: GO:0016197 - endosomal transport [Evidence IMP] [PMID 20526336]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 18178563]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 18178563]; GO_process: GO:0007034 - vacuolar transport [Evidence IGI] [PMID 20526336]
AWJ20_42	Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 23986483]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IDA] [PMID 23129774]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 20375281]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 16874038]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20375281]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10727015]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 23129774]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 16079147]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 16874038]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20375281]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 8619313]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 16079147]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 16874038]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0034497 - protein localization to pre-autophagosomal structure [Evidence IMP] [PMID 20375281]; GO_process: GO:0034497 - protein localization to pre-autophagosomal structure [Evidence IMP] [PMID 23129774]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IMP] [PMID 16079147]
AWJ20_43	Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8813764]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 15169867]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003848 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0003848 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [Evidence IDA] [PMID 15169867]; GO_function: GO:0003848 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [Evidence ISS] [PMID 9234673]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004150 - dihydroneopterin aldolase activity [Evidence IEA,IEA]; GO_function: GO:0004150 - dihydroneopterin aldolase activity [Evidence ISS] [PMID 11752249]; GO_function: GO:0004150 - dihydroneopterin aldolase activity [Evidence IDA] [PMID 15169867]; GO_function: GO:0004156 - dihydropteroate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004156 - dihydropteroate synthase activity [Evidence IMP] [PMID 11731153]; GO_function: GO:0004156 - dihydropteroate synthase activity [Evidence IDA] [PMID 15169867]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006760 - folic acid-containing compound metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0042558 - pteridine-containing compound metabolic process [Evidence IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IMP] [PMID 11731153]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IMP] [PMID 15169867]
AWJ20_45	Basic leucine zipper (bZIP) transcription factor; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 9372930]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA] [PMID 9372930]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9372930]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_46	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 9920864]; GO_process: GO:1902047 - polyamine transmembrane transport [Evidence IMP] [PMID 24136413]; GO_process: GO:0015847 - putrescine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_47	AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ubiquitin ligase; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA] [PMID 12393914]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA,IPI] [PMID 2481228]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IPI] [PMID 9121458]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 11331606]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17237508]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IPI] [PMID 11331606]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005641 - nuclear envelope lumen [Evidence IDA] [PMID 17237508]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11331606]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17237508]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 11486005]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 2557546]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 7913470]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 11486005]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 2557546]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 7913470]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0042710 - biofilm formation [Evidence IMP] [PMID 12024013]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007155 - cell adhesion [Evidence IMP] [PMID 12556493]; GO_process: GO:0006995 - cellular response to nitrogen starvation [Evidence IDA] [PMID 12024013]; GO_process: GO:0071940 - fungal-type cell wall assembly [Evidence IMP] [PMID 24486034]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 11095711]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12556493]; GO_process: GO:0017148 - negative regulation of translation [Evidence IGI,IMP] [PMID 18955495]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:1900436 - positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [Evidence IMP] [PMID 22904036]; GO_process: GO:0045722 - positive regulation of gluconeogenesis [Evidence IMP] [PMID 8628258]; GO_process: GO:0045722 - positive regulation of gluconeogenesis [Evidence IMP] [PMID 8710504]; GO_process: GO:0045722 - positive regulation of gluconeogenesis [Evidence IMP] [PMID 9111319]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 11486005]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 12024013]; GO_process: GO:0006109 - regulation of carbohydrate metabolic process [Evidence IGI,IPI] [PMID 12167649]; GO_process: GO:0001302 - replicative cell aging [Evidence IGI,IMP] [PMID 10921902]
AWJ20_49	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12242223]; GO_function: GO:0003677 - DNA binding [Evidence ISS] [PMID 7498786]; GO_function: GO:0070403 - NAD+ binding [Evidence IEA]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IMP] [PMID 16815704]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 7498786]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16815704]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0046459 - short-chain fatty acid metabolic process [Evidence IMP] [PMID 12618394]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_50	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_53	Nuclear type II J heat shock protein of the E. coli dnaJ family; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly; GO_component: GO:0005634 - nucleus [Evidence TAS] [PMID 15170475]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 8045411]; GO_process: GO:0006457 - protein folding [Evidence ISS] [PMID 8045411]
AWJ20_58	Mitochondrial intermembrane space protein; involved in phospholipid metabolism; has role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 19506038]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 19506038]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032048 - cardiolipin metabolic process [Evidence IGI] [PMID 19506038]; GO_process: GO:0042407 - cristae formation [Evidence IGI,IMP] [PMID 19221197]; GO_process: GO:2001246 - negative regulation of phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 22403410]; GO_process: GO:0046337 - phosphatidylethanolamine metabolic process [Evidence IGI,IMP] [PMID 19221197]
AWJ20_59	Mitochondrial asparaginyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 9030748]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004816 - asparagine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004816 - asparagine-tRNA ligase activity [Evidence IDA] [PMID 9030748]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation [Evidence IDA] [PMID 9030748]; GO_process: GO:0070145 - mitochondrial asparaginyl-tRNA aminoacylation [Evidence IMP] [PMID 9030748]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_60	Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0042597 - periplasmic space [Evidence IDA] [PMID 8051052]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8051052]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IMP] [PMID 8051052]; GO_function: GO:0004620 - phospholipase activity [Evidence IEA]; GO_process: GO:0006650 - glycerophospholipid metabolic process [Evidence IMP] [PMID 8051052]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0036151 - phosphatidylcholine acyl-chain remodeling [Evidence IMP] [PMID 23501167]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]
AWJ20_61	Putative glycoside hydrolase of the mitochondrial intermembrane space; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_62	Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 20841380]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15550248]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 16520372]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,ISS] [PMID 8299420]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 15265985]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI,IMP] [PMID 20841380]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20841380]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0016559 - peroxisome fission [Evidence IMP] [PMID 18445678]; GO_process: GO:0007031 - peroxisome organization [Evidence IDA,IGI,IMP] [PMID 12707309]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8299420]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP] [PMID 8299420]
AWJ20_63	Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments and a polyproline domain which can nucleate actin filaments independent of Arp2/3; mutants are defective in actin cytoskeleton dependent processes such as: endocytosis, bud site selection and cytokinesis; localizes with the Arp2/3 complex to actin cortical patches; homolog of the Wiskott-Aldrich Syndrome protein (WASP), implicated in severe immunodeficiency; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10512884]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 9024694]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 10512884]; GO_function: GO:0003779 - actin binding [Evidence IDA,IPI] [PMID 23290554]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI,IMP] [PMID 18177206]; GO_process: GO:0007015 - actin filament organization [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IDA] [PMID 9214384]; GO_process: GO:0030041 - actin filament polymerization [Evidence IDA] [PMID 22973053]; GO_process: GO:0045010 - actin nucleation [Evidence IDA] [PMID 23290554]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation [Evidence IEA]; GO_process: GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation [Evidence IDA] [PMID 10322115]; GO_process: GO:0032233 - positive regulation of actin filament bundle assembly [Evidence IDA] [PMID 19158382]
AWJ20_66	Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p; GO_component: GO:0030015 - CCR4-NOT core complex [Evidence IPI] [PMID 11733989]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA,IPI] [PMID 21406554]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 11733989]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_68	NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 11361135]; GO_function: GO:0000210 - NAD+ diphosphatase activity [Evidence IEA]; GO_function: GO:0000210 - NAD+ diphosphatase activity [Evidence IDA] [PMID 11361135]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006734 - NADH metabolic process [Evidence IDA] [PMID 11361135]
AWJ20_69	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_70	Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9261170]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004416 - hydroxyacylglutathione hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004416 - hydroxyacylglutathione hydrolase activity [Evidence IDA,IGI,IMP] [PMID 9261170]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IEA]; GO_process: GO:0019243 - methylglyoxal catabolic process to D-lactate [Evidence IDA,IGI,IMP] [PMID 9261170]
AWJ20_73	Ubiquitin-binding protein; contains a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; CUE5 has a paralog, DON1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 12628920]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_74	Poly(A)RNA binding protein involved in nuclear mRNA export; component of the nuclear pore; ortholog of human TAP; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0042272 - nuclear RNA export factor complex [Evidence IPI] [PMID 9774696]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12524544]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12411502]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 10722667]; GO_process: GO:0051028 - mRNA transport [Evidence IEA,IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 17434126]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 22956913]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_75	C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0000249 - C-22 sterol desaturase activity [Evidence IDA] [PMID 8543054]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8543054]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 8635732]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
AWJ20_76	GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_78	N-glycosylated integral membrane protein of the ER and plasma membrane; functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14729456]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IEA]; GO_function: GO:0005262 - calcium channel activity [Evidence IMP] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IMP] [PMID 9343395]; GO_function: GO:0015275 - stretch-activated, cation-selective, calcium channel activity [Evidence IDA] [PMID 10436155]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA] [PMID 10958666]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_79	Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype); GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 9358157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 9358157]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IGI] [PMID 9358157]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 9358157]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_80	Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0031211 - endoplasmic reticulum palmitoyltransferase complex [Evidence IPI] [PMID 12193598]; GO_component: GO:0042406 - extrinsic component of endoplasmic reticulum membrane [Evidence IDA] [PMID 12379641]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IDA] [PMID 12193598]; GO_process: GO:0018345 - protein palmitoylation [Evidence IDA] [PMID 12193598]; GO_process: GO:0018345 - protein palmitoylation [Evidence IMP] [PMID 16751107]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 7532279]
AWJ20_81	Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis; GO_component: GO:0016021 - integral component of membrane [Evidence IBA,IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11251115]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IRD]; GO_component: GO:0005774 - vacuolar membrane [Evidence IDA] [PMID 23509072]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015421 - oligopeptide-transporting ATPase activity [Evidence IBA]; GO_function: GO:0015421 - oligopeptide-transporting ATPase activity [Evidence ISA] [PMID 11251115]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IDA] [PMID 23509072]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090374 - oligopeptide export from mitochondrion [Evidence ISA] [PMID 11251115]; GO_process: GO:0006857 - oligopeptide transport [Evidence ISA] [PMID 11251115]; GO_process: GO:0055085 - transmembrane transport [Evidence IBA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_82	Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 2203793]; GO_function: GO:1901235 - (R)-carnitine transmembrane transporter activity [Evidence IMP] [PMID 23755272]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IMP] [PMID 2203793]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_function: GO:0034228 - ethanolamine transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_process: GO:1900749 - (R)-carnitine transport [Evidence IMP] [PMID 23755272]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015871 - choline transport [Evidence IMP] [PMID 2203793]; GO_process: GO:0015871 - choline transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0034229 - ethanolamine transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0031460 - glycine betaine transport [Evidence IMP] [PMID 16487344]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_83	Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23047103]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015809 - arginine transport [Evidence IGI,IMP] [PMID 23047103]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_84	Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962064]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16962064]
AWJ20_88	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004421 - hydroxymethylglutaryl-CoA synthase activity [Evidence IEA,IEA]; GO_function: GO:0004421 - hydroxymethylglutaryl-CoA synthase activity [Evidence IMP] [PMID 6148937]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 6148937]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_89	Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 19506040]; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 19506040]
AWJ20_90	Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_92	F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15537705]; GO_component: GO:0051286 - cell tip [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15537705]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 11287615]; GO_function: GO:0000149 - SNARE binding [Evidence IMP,IPI] [PMID 11287615]; GO_function: GO:0000149 - SNARE binding [Evidence IPI] [PMID 15537705]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 15537705]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 24272750]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 10769031]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048278 - vesicle docking [Evidence IEA]
AWJ20_93	Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia; GO_component: GO:0097078 - FAl1-SGD1 complex [Evidence IPI] [PMID 21576267]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11042259]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA,ISS] [PMID 11042259]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 11042259]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 12073033]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]
AWJ20_94	Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004595 - pantetheine-phosphate adenylyltransferase activity [Evidence IEA]; GO_function: GO:0004595 - pantetheine-phosphate adenylyltransferase activity [Evidence ISS] [PMID 11923312]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 11923312]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]
AWJ20_95	Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 20956557]; GO_component: GO:0005684 - U2-type spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 20956557]
AWJ20_96	Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication; GO_component: GO:0005960 - glycine cleavage complex [Evidence IMP] [PMID 7498764]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 11926067]; GO_component: GO:0009353 - mitochondrial oxoglutarate dehydrogenase complex [Evidence IDA] [PMID 2072900]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004148 - dihydrolipoyl dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004148 - dihydrolipoyl dehydrogenase activity [Evidence IDA] [PMID 2821168]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IMP] [PMID 7498764]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016668 - oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Evidence IEA]; GO_function: GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity [Evidence IMP] [PMID 3528755]; GO_function: GO:0004738 - pyruvate dehydrogenase activity [Evidence IMP] [PMID 3528755]; GO_process: GO:0006103 - 2-oxoglutarate metabolic process [Evidence IMP] [PMID 3528755]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IMP] [PMID 7498764]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IMP] [PMID 7498764]; GO_process: GO:0042743 - hydrogen peroxide metabolic process [Evidence IGI,IMP] [PMID 17110466]; GO_process: GO:0006550 - isoleucine catabolic process [Evidence IMP] [PMID 1479341]; GO_process: GO:0006552 - leucine catabolic process [Evidence IMP] [PMID 1479341]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 3528755]; GO_process: GO:0006574 - valine catabolic process [Evidence IMP] [PMID 1479341]
AWJ20_98	Strand exchange protein; forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 9427283]; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 11459983]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 8066464]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0000150 - recombinase activity [Evidence IDA] [PMID 8066464]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 20371520]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006259 - DNA metabolic process [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IDA] [PMID 22955832]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0045002 - double-strand break repair via single-strand annealing [Evidence IMP] [PMID 8849880]; GO_process: GO:0030491 - heteroduplex formation [Evidence IDA] [PMID 10506208]; GO_process: GO:0000709 - meiotic joint molecule formation [Evidence IMP] [PMID 1581961]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 16581767]; GO_process: GO:0042148 - strand invasion [Evidence IDA] [PMID 8066464]; GO_process: GO:0042148 - strand invasion [Evidence IDA] [PMID 9271413]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IMP] [PMID 11238918]
AWJ20_99	Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11747810]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 19129178]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 1918080]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11747810]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 1918080]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11914276]; GO_function: GO:0008061 - chitin binding [Evidence IEA]; GO_function: GO:0004568 - chitinase activity [Evidence IEA,IEA]; GO_function: GO:0008843 - endochitinase activity [Evidence IDA] [PMID 6799506]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IC] [PMID 3033651]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 1918080]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]
AWJ20_101	Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0061133 - endopeptidase activator activity [Evidence IGI] [PMID 9207060]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
AWJ20_103	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p); TORC2 is a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain; GO_component: GO:0031932 - TORC2 complex [Evidence IEA]; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12631735]; GO_process: GO:0031929 - TOR signaling [Evidence IEA]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IPI] [PMID 12408816]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 15809876]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 15809876]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IEA]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IGI] [PMID 9804843]
AWJ20_104	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10022925]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 10022925]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 11105761]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 17347149]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11086007]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI] [PMID 23212245]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_105	Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034457 - Mpp10 complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0032040 - small-subunit processome [Evidence IMP] [PMID 12242301]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9315638]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9315638]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9315638]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_107	E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning Dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA,IPI] [PMID 7947791]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA,IMP] [PMID 2007123]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA,IMP] [PMID 2007123]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_114	Heme A:farnesyltransferase; catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0008495 - protoheme IX farnesyltransferase activity [Evidence IEA]; GO_function: GO:0008495 - protoheme IX farnesyltransferase activity [Evidence ISS] [PMID 8118433]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0048034 - heme O biosynthetic process [Evidence IEA]; GO_process: GO:0006784 - heme a biosynthetic process [Evidence IMP] [PMID 8118433]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA,IEA]
AWJ20_116	Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11094088]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11094088]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 9560389]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IEA]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IMP] [PMID 9438131]; GO_function: GO:0043812 - phosphatidylinositol-4-phosphate phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA] [PMID 10224048]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 9438131]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_118	Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19502581]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 19502581]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IPI] [PMID 7954793]; GO_function: GO:0070300 - phosphatidic acid binding [Evidence IDA] [PMID 19502581]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence TAS] [PMID 10047442]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence TAS] [PMID 10047442]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_119	Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004347 - glucose-6-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004347 - glucose-6-phosphate isomerase activity [Evidence IMP] [PMID 3007940]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 3020369]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 3007940]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IMP] [PMID 7901008]
AWJ20_124	Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10899124]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IMP] [PMID 12549926]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA,IMP] [PMID 9786867]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 22128164]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 14517251]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA,IMP] [PMID 16720702]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 22128164]; GO_process: GO:0034225 - regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation [Evidence IMP] [PMID 9271382]; GO_process: GO:0034225 - regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation [Evidence IMP] [PMID 9786867]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_125	Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005768 - endosome [Evidence IPI] [PMID 9700157]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0030904 - retromer complex [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030906 - retromer complex, inner shell [Evidence IMP] [PMID 9700157]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007034 - vacuolar transport [Evidence IEA]
AWJ20_127	hypothetical protein with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003962 - cystathionine gamma-synthase activity [Evidence IEA]; GO_function: GO:0003962 - cystathionine gamma-synthase activity [Evidence ISS] [PMID 10821189]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence ISS] [PMID 10821189]
AWJ20_131	Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11069679]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IEA]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IDA,IMP] [PMID 9234685]; GO_process: GO:0072488 - ammonium transmembrane transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEA,IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IMP] [PMID 9234685]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 9234685]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9482721]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_132	one of two likely peroxisomal copper amine oxidase genes; similar to A.niger AO-I; allele of CaO19.10662
AWJ20_133	Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 10037752]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 16034811]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 10037752]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 8991513]
AWJ20_134	Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 10037752]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 9434768]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence ISS] [PMID 9653120]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence TAS] [PMID 10037752]; GO_process: GO:0006080 - substituted mannan metabolic process [Evidence TAS] [PMID 10037752]
AWJ20_135	Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9860978]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IPI] [PMID 11509570]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 9860978]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_136	similar to S. cerevisiae URB2 (YJR041C) essential nucleolar protein (Unhealthy Ribosome Biogenesis); allele of CaO19.5884
AWJ20_137	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_139	2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IDA,IGI,IMP] [PMID 7954819]; GO_process: GO:0019988 - charged-tRNA amino acid modification [Evidence IGI,IMP] [PMID 7954819]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_140	2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IDA,IGI,IMP] [PMID 7954819]; GO_process: GO:0019988 - charged-tRNA amino acid modification [Evidence IGI,IMP] [PMID 7954819]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_141	Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR4 has a paralog, FPR3, that arose from the whole genome duplication; GO_component: GO:0000785 - chromatin [Evidence IDA] [PMID 14981505]; GO_component: GO:0000785 - chromatin [Evidence IDA] [PMID 16959570]; GO_component: GO:0016020 - membrane [Evidence IBA]; GO_component: GO:0005730 - nucleolus [Evidence IBA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14981505]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9371805]; GO_function: GO:0005528 - FK506 binding [Evidence IBA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0005527 - macrolide binding [Evidence IDA] [PMID 9371805]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 14981505]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 16959570]; GO_process: GO:0000412 - histone peptidyl-prolyl isomerization [Evidence IEA]; GO_process: GO:0000412 - histone peptidyl-prolyl isomerization [Evidence IDA] [PMID 16959570]; GO_process: GO:0000415 - negative regulation of histone H3-K36 methylation [Evidence IMP] [PMID 16959570]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 16846601]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 24297734]; GO_process: GO:0018208 - peptidyl-proline modification [Evidence IBA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 16959570]
AWJ20_142	Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10427089]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11038189]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 10427089]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11038189]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15466482]; GO_function: GO:0000149 - SNARE binding [Evidence IDA] [PMID 10427089]; GO_process: GO:0006887 - exocytosis [Evidence IMP,IPI] [PMID 10427089]; GO_process: GO:0031340 - positive regulation of vesicle fusion [Evidence IDA] [PMID 15466482]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IPI] [PMID 10427089]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_143	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 9032243]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15149594]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 11983171]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 16581788]; GO_function: GO:0000983 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [Evidence IDA] [PMID 16581788]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 16581788]; GO_function: GO:0001089 - TFIIF-class binding transcription factor activity [Evidence IMP,IPI] [PMID 9032243]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11983171]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 16582434]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 21737840]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15149594]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IMP] [PMID 9891041]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15180994]; GO_process: GO:2001255 - positive regulation of histone H3-K36 trimethylation [Evidence IMP] [PMID 17948059]; GO_process: GO:2001165 - positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 18469135]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14710186]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 20299458]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 12667454]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 18194564]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:2001166 - regulation of histone H2B ubiquitination [Evidence IMP] [PMID 12876294]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12667454]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12876294]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 15180994]; GO_process: GO:2001163 - regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 15149594]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 18194564]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11884586]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10219085]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 16246725]; GO_process: GO:0001015 - snoRNA transcription from an RNA polymerase II promoter [Evidence IDA,IMP] [PMID 16246725]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IMP] [PMID 19164765]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 11927560]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IGI,IMP] [PMID 20299458]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_144	S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14609944]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0000095 - S-adenosyl-L-methionine transmembrane transporter activity [Evidence IDA,IGI,IMP] [PMID 14609944]; GO_process: GO:0015805 - S-adenosyl-L-methionine transport [Evidence IDA,IGI,IMP] [PMID 14609944]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_145	Cysteine desulfurase; involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria; GO_component: GO:1990221 - L-cysteine desulfurase complex [Evidence IPI] [PMID 24045011]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10406803]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19720832]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 11110795]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19720832]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0031071 - cysteine desulfurase activity [Evidence IEA,IEA]; GO_function: GO:0031071 - cysteine desulfurase activity [Evidence IDA] [PMID 12065597]; GO_function: GO:0031071 - cysteine desulfurase activity [Evidence IDA] [PMID 15220327]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 10551871]; GO_process: GO:0006534 - cysteine metabolic process [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12970193]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IDA] [PMID 15220327]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0070903 - mitochondrial tRNA thio-modification [Evidence IMP] [PMID 14722066]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IMP] [PMID 14722066]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IMP] [PMID 15220327]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_146	Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence ISS] [PMID 10600387]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 10600387]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence ISS] [PMID 10600387]; GO_process: GO:0051289 - protein homotetramerization [Evidence IDA] [PMID 10600387]
AWJ20_147	Component of the GTPase-activating Bfa1p-Bub2p complex; involved in multiple cell cycle checkpoint pathways that control exit from mitosis; specifically required when telomeres are damaged, but not for all types of chromosomal DNA damage; phosphorylated by the Polo-like kinase Cdc5p; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 10220406]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 15147270]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA] [PMID 16682821]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IGI,IMP] [PMID 16039591]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IMP] [PMID 15147270]
AWJ20_148	Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 1618910]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IGI] [PMID 1618910]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007019 - microtubule depolymerization [Evidence IMP] [PMID 19041752]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 9813090]; GO_process: GO:0030541 - plasmid partitioning [Evidence IMP] [PMID 19364922]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 9813090]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618897]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618910]
AWJ20_149	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9452453]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence ISS] [PMID 11435415]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9452453]
AWJ20_151	Protein involved in bud-site selection; required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12972503]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 7730410]; GO_function: GO:0005089 - Rho guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 2065354]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0032319 - regulation of Rho GTPase activity [Evidence IEA]; GO_process: GO:0035023 - regulation of Rho protein signal transduction [Evidence IEA]
AWJ20_153	Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 10377429]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 15623581]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 15623581]; GO_process: GO:0034394 - protein localization to cell surface [Evidence IGI,IMP] [PMID 10377429]
AWJ20_154	Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport; GO_component: GO:0005686 - U2 snRNP [Evidence IPI] [PMID 10369685]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 15565172]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 16314500]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0030620 - U2 snRNA binding [Evidence IPI] [PMID 10369685]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 16314500]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI,IMP] [PMID 9819400]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IDA] [PMID 10369685]
AWJ20_155	Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 10409731]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043200 - response to amino acid [Evidence IMP] [PMID 10409731]
AWJ20_156	hypothetical protein; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_158	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_162	Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IMP] [PMID 21347277]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 11389843]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 17483413]
AWJ20_163	DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family of DNA translocases; forms nuclear foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 12399378]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 10506208]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 10506208]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0032392 - DNA geometric change [Evidence IDA] [PMID 10506208]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 12577053]; GO_process: GO:0045002 - double-strand break repair via single-strand annealing [Evidence IMP] [PMID 8849880]; GO_process: GO:0045003 - double-strand break repair via synthesis-dependent strand annealing [Evidence TAS] [PMID 10357855]; GO_process: GO:0030491 - heteroduplex formation [Evidence IDA] [PMID 10506208]; GO_process: GO:0032079 - positive regulation of endodeoxyribonuclease activity [Evidence IDA] [PMID 19129197]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IMP] [PMID 11238918]
AWJ20_164	Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 6025308]; GO_component: GO:0005835 - fatty acid synthase complex [Evidence IDA] [PMID 65153]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004316 - 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0004316 - 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [Evidence IDA] [PMID 365179]; GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity [Evidence IEA]; GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IGI] [PMID 10785388]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IMP] [PMID 65153]; GO_function: GO:0004321 - fatty-acyl-CoA synthase activity [Evidence IEA]; GO_function: GO:0008897 - holo-[acyl-carrier-protein] synthase activity [Evidence IEA]; GO_function: GO:0008897 - holo-[acyl-carrier-protein] synthase activity [Evidence IGI,IMP] [PMID 10785388]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0042759 - long-chain fatty acid biosynthetic process [Evidence IMP] [PMID 1735446]; GO_process: GO:0009059 - macromolecule biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_165	ER membrane glycoprotein subunit of the GPI transamidase complex; adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IEA]; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IDA] [PMID 11598210]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8978684]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IMP] [PMID 10793132]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IMP] [PMID 11598210]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP] [PMID 11598210]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_166	Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 10322435]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
AWJ20_168	UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21211725]
AWJ20_169	High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_171	Mitochondrial translation release factor; involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 1475194]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 8265342]; GO_function: GO:0003747 - translation release factor activity [Evidence IEA]; GO_function: GO:0003747 - translation release factor activity [Evidence IDA] [PMID 10748224]; GO_function: GO:0003747 - translation release factor activity [Evidence IGI] [PMID 1475194]; GO_function: GO:0016149 - translation release factor activity, codon specific [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 14734569]; GO_process: GO:0070126 - mitochondrial translational termination [Evidence IGI] [PMID 1475194]; GO_process: GO:0070126 - mitochondrial translational termination [Evidence IMP] [PMID 15827612]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IMP] [PMID 1475194]
AWJ20_174	Integral membrane protein involved in GPI anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the glycosylphosphatidylinositol (GPI) core structure; human PIG-Bp is a functional homolog; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9639537]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004584 - dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity [Evidence IMP] [PMID 9576863]; GO_function: GO:0004584 - dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity [Evidence IMP] [PMID 9639537]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 9759715]
AWJ20_175	Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11812822]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24034606]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11812822]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24034606]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0016799 - hydrolase activity, hydrolyzing N-glycosyl compounds [Evidence IEA]; GO_function: GO:0004844 - uracil DNA N-glycosylase activity [Evidence IEA,IEA]; GO_function: GO:0004844 - uracil DNA N-glycosylase activity [Evidence IDA] [PMID 2644266]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 1938887]; GO_process: GO:0006284 - base-excision repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_176	Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 11604502]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 11604502]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 11604502]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IGI,IPI] [PMID 11950926]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IPI] [PMID 17452441]
AWJ20_178	ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription; GO_component: GO:0031011 - Ino80 complex [Evidence IDA] [PMID 10361278]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA,IMP] [PMID 10952318]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 10952318]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 23207916]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 18258182]; GO_process: GO:0043486 - histone exchange [Evidence IDA] [PMID 21241891]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IMP] [PMID 17681272]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 21135121]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17681272]; GO_process: GO:0051983 - regulation of chromosome segregation [Evidence IMP] [PMID 23207916]; GO_process: GO:0043618 - regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 19620280]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IGI] [PMID 23390378]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 10952318]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_179	Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0035529 - NADH pyrophosphatase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IGI,IMP] [PMID 16278456]; GO_function: GO:0047429 - nucleoside-triphosphate diphosphatase activity [Evidence IDA,IGI,IMP] [PMID 16278456]; GO_function: GO:0004551 - nucleotide diphosphatase activity [Evidence IEA]; GO_function: GO:0004551 - nucleotide diphosphatase activity [Evidence ISS] [PMID 16278456]; GO_function: GO:0004528 - phosphodiesterase I activity [Evidence IEA]; GO_function: GO:0004528 - phosphodiesterase I activity [Evidence ISS] [PMID 16278456]; GO_process: GO:0016036 - cellular response to phosphate starvation [Evidence IEP,IMP] [PMID 16278456]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0009141 - nucleoside triphosphate metabolic process [Evidence IMP] [PMID 16278456]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence ISS] [PMID 16278456]
AWJ20_180	hypothetical protein with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
AWJ20_181	Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990070 - TRAPPI protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0033106 - cis-Golgi network membrane [Evidence IDA] [PMID 9564032]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IGI] [PMID 11102533]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IGI] [PMID 17041589]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 17110339]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IMP] [PMID 17287728]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IGI] [PMID 8590804]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 8590804]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_182	Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA,IEA]; GO_function: GO:0004496 - mevalonate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004496 - mevalonate kinase activity [Evidence IDA] [PMID 16477420]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0010142 - farnesyl diphosphate biosynthetic process, mevalonate pathway [Evidence IMP] [PMID 200835]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IEA]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IMP] [PMID 200835]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_183	Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_184	GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003922 - GMP synthase (glutamine-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0003922 - GMP synthase (glutamine-hydrolyzing) activity [Evidence IMP,ISS] [PMID 8112582]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016462 - pyrophosphatase activity [Evidence IEA]; GO_process: GO:0006177 - GMP biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006177 - GMP biosynthetic process [Evidence IMP] [PMID 20980241]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA]
AWJ20_185	Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (RAM2-RAM1 heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (RAM2-CDC43 heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor; GO_component: GO:0005953 - CAAX-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 1400380]; GO_component: GO:0005965 - protein farnesyltransferase complex [Evidence IDA] [PMID 1763050]; GO_function: GO:0004662 - CAAX-protein geranylgeranyltransferase activity [Evidence IEA]; GO_function: GO:0004662 - CAAX-protein geranylgeranyltransferase activity [Evidence IDA] [PMID 1400380]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0004660 - protein farnesyltransferase activity [Evidence IEA]; GO_function: GO:0004660 - protein farnesyltransferase activity [Evidence IDA] [PMID 1763050]; GO_function: GO:0004661 - protein geranylgeranyltransferase activity [Evidence IDA] [PMID 2034682]; GO_function: GO:0008318 - protein prenyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0007323 - peptide pheromone maturation [Evidence IDA] [PMID 1763050]; GO_process: GO:0018343 - protein farnesylation [Evidence IDA] [PMID 1763050]; GO_process: GO:0018344 - protein geranylgeranylation [Evidence IDA] [PMID 1400380]; GO_process: GO:0018342 - protein prenylation [Evidence IEA]
AWJ20_186	Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003941 - L-serine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0003941 - L-serine ammonia-lyase activity [Evidence IDA] [PMID 7042346]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IDA] [PMID 7042346]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0006565 - L-serine catabolic process [Evidence IGI] [PMID 7042346]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006567 - threonine catabolic process [Evidence IGI] [PMID 7042346]
AWJ20_187	Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11112701]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16861225]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISS] [PMID 11112701]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12773575]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IDA] [PMID 16888624]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17443350]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP,IPI] [PMID 12773575]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_189	Putative zinc finger protein; YPR013C is not an essential gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 23012409]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_191	Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; this complex also contains Anp1p, Mnn10p, Mnn11p, and Hoc1p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 9430634]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 19249370]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 9430634]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA] [PMID 19249370]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA] [PMID 9430634]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_192	Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8862519]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 8862519]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8862519]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 8862519]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IGI,IMP] [PMID 8862519]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_193	Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16850348]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 10869563]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 10869563]
AWJ20_194	Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0032777 - Piccolo NuA4 histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0032777 - Piccolo NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 12782659]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 10911987]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 17274630]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 15610740]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10911987]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 22539722]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 10911987]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_195	Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005853 - eukaryotic translation elongation factor 1 complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12824466]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 8465602]; GO_function: GO:0005543 - phospholipid binding [Evidence IDA] [PMID 8465602]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IMP] [PMID 12824466]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12824466]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IGI] [PMID 8041634]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]
AWJ20_199	Actin- and formin-interacting protein; participates in actin cable assembly and organization as a nucleation-promoting factor (NPF) for formins Bni1p and Bnr1p; a triple helical coiled-coil domain in the C-terminal region interacts with Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11071900]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 23671312]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9247651]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11071900]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 23671312]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9247651]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11071900]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9247651]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9082982]; GO_component: GO:0000133 - polarisome [Evidence IDA] [PMID 9632790]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 17416900]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 7719850]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 9247651]; GO_function: GO:0005519 - cytoskeletal regulatory protein binding [Evidence IPI] [PMID 15923184]; GO_function: GO:0005519 - cytoskeletal regulatory protein binding [Evidence IDA] [PMID 9082982]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 23671312]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IGI,IMP] [PMID 23671312]; GO_process: GO:0030953 - astral microtubule organization [Evidence IMP] [PMID 22608510]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 8657162]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 9247651]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 10866679]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 9247651]; GO_process: GO:0034652 - extrachromosomal circular DNA localization involved in cell aging [Evidence IMP] [PMID 18660802]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IGI,IMP] [PMID 17237521]; GO_process: GO:0090338 - positive regulation of formin-nucleated actin cable assembly [Evidence IDA,IGI] [PMID 14657240]; GO_process: GO:0090338 - positive regulation of formin-nucleated actin cable assembly [Evidence IDA] [PMID 15923184]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 10085294]
AWJ20_200	Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12101098]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12101098]; GO_component: GO:0000333 - telomerase catalytic core complex [Evidence IDA,IPI] [PMID 15813705]; GO_component: GO:0005697 - telomerase holoenzyme complex [Evidence IDA,IPI] [PMID 10898986]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0003720 - telomerase activity [Evidence IDA] [PMID 15813705]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 17656141]; GO_function: GO:0003721 - telomeric template RNA reverse transcriptase activity [Evidence IEA]; GO_function: GO:0003721 - telomeric template RNA reverse transcriptase activity [Evidence TAS] [PMID 11884619]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IGI] [PMID 18627461]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IDA,IMP] [PMID 15813705]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 8978029]
AWJ20_201	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 9154831]; GO_component: GO:0000228 - nuclear chromosome [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 9154831]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0031055 - chromatin remodeling at centromere [Evidence IMP] [PMID 12697820]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 12697820]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16024655]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0033262 - regulation of nuclear cell cycle DNA replication [Evidence IGI] [PMID 17542652]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_202	Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 11309124]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 19820940]; GO_process: GO:0010969 - regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 19820940]
AWJ20_203	Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0032221 - Rpd3S complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0032221 - Rpd3S complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 11036083]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 11036083]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 11036083]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16286007]; GO_process: GO:0060195 - negative regulation of antisense RNA transcription [Evidence IMP] [PMID 21248844]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IMP] [PMID 16364921]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 19417103]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11036083]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 19948887]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_204	Kynurenine 3-mono oxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004502 - kynurenine 3-monooxygenase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004502 - kynurenine 3-monooxygenase activity [Evidence IMP] [PMID 15806102]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IGI] [PMID 12062417]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA]; GO_process: GO:0043420 - anthranilate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0019805 - quinolinate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA,IEA]
AWJ20_205	Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15353583]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 12672825]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence ISS] [PMID 14690591]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IPI] [PMID 12672825]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 14690608]; GO_process: GO:0051276 - chromosome organization [Evidence IMP] [PMID 18439903]; GO_process: GO:0043968 - histone H2A acetylation [Evidence IEA]; GO_process: GO:0043967 - histone H4 acetylation [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 14690591]; GO_process: GO:0043486 - histone exchange [Evidence IPI] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_206	Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats; GO_component: GO:0070545 - PeBoW complex [Evidence IDA,IPI] [PMID 16287855]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11583614]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IGI] [PMID 10454593]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 15100437]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
AWJ20_207	Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0004360 - glutamine-fructose-6-phosphate transaminase (isomerizing) activity [Evidence IEA,IEA]; GO_function: GO:0004360 - glutamine-fructose-6-phosphate transaminase (isomerizing) activity [Evidence IDA] [PMID 2656689]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IEA]; GO_process: GO:0016051 - carbohydrate biosynthetic process [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IGI] [PMID 11895440]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_208	hypothetical protein with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_210	AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 9467951]; GO_component: GO:0005884 - actin filament [Evidence IDA] [PMID 9467951]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 11805329]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 9467951]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 9467951]; GO_function: GO:0052735 - tRNA (cytosine-3-)-methyltransferase activity [Evidence IDA,IMP] [PMID 21518804]; GO_function: GO:0052735 - tRNA (cytosine-3-)-methyltransferase activity [Evidence IDA] [PMID 21518805]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IDA] [PMID 9467951]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 21518804]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 21518805]
AWJ20_211	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
AWJ20_213	Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_215	top hit is XP_002839470.1 originated in Tuber melanosporum Mel28; conserved fungal protein
AWJ20_216	Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing; GO_component: GO:0030691 - Noc2p-Noc3p complex [Evidence IPI] [PMID 11371346]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 22421151]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11371346]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 11371346]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12110182]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12110182]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IDA] [PMID 12110182]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 22421151]; GO_process: GO:0006364 - rRNA processing [Evidence IDA] [PMID 12110182]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_222	Peroxisomal membrane protein (PMP); required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16009135]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 1894692]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 23900285]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9418908]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP] [PMID 23900285]; GO_process: GO:0032581 - ER-dependent peroxisome organization [Evidence IDA] [PMID 17646399]; GO_process: GO:0032581 - ER-dependent peroxisome organization [Evidence IMP] [PMID 20427571]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IMP] [PMID 19948495]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0045046 - protein import into peroxisome membrane [Evidence IMP] [PMID 10637226]
AWJ20_224	8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 10922370]; GO_function: GO:0008413 - 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [Evidence IDA,IMP] [PMID 15475388]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016462 - pyrophosphatase activity [Evidence IDA] [PMID 10922370]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15475388]; GO_process: GO:0009132 - nucleoside diphosphate metabolic process [Evidence IEA]
AWJ20_227	Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 16239147]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 9566960]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 12477802]; GO_function: GO:0008092 - cytoskeletal protein binding [Evidence IPI,ISS] [PMID 10388809]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20610658]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 8590801]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 7891662]; GO_process: GO:0031532 - actin cytoskeleton reorganization [Evidence IMP] [PMID 7891662]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 11096097]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20610658]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 1776363]; GO_process: GO:0042594 - response to starvation [Evidence IMP] [PMID 1776363]
AWJ20_231	Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10975256]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9701810]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence ISA] [PMID 7935367]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:2001196 - positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine [Evidence IMP] [PMID 3123231]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 11952910]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3123231]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 7935367]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_234	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IMP] [PMID 17229886]
AWJ20_235	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IMP] [PMID 17229886]
AWJ20_236	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p); this complex catalyzes nucleotide exchange on Ypt6p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10990452]; GO_component: GO:0000139 - Golgi membrane [Evidence IPI] [PMID 10990452]; GO_component: GO:0034066 - RIC1-RGP1 guanyl-nucleotide exchange factor complex [Evidence IPI] [PMID 10990452]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 10990452]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA,IPI] [PMID 10990452]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 10990452]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IMP] [PMID 11082047]
AWJ20_237	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16541108]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_238	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 9920864]; GO_process: GO:1902047 - polyamine transmembrane transport [Evidence IMP] [PMID 24136413]; GO_process: GO:0015847 - putrescine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_239	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 5571830]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003985 - acetyl-CoA C-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003985 - acetyl-CoA C-acetyltransferase activity [Evidence IDA] [PMID 7989303]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_241	Non-ATPase base subunit of the 19S RP of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the regulatory particle (RP); binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IMP] [PMID 15242647]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IPI] [PMID 15907469]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0031593 - polyubiquitin binding [Evidence IDA] [PMID 8887631]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 9741626]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15242647]
AWJ20_242	Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23509072]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_243	Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0009337 - sulfite reductase complex (NADPH) [Evidence IDA] [PMID 6751400]; GO_component: GO:0009337 - sulfite reductase complex (NADPH) [Evidence IDA] [PMID 9003798]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004783 - sulfite reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0004783 - sulfite reductase (NADPH) activity [Evidence IDA] [PMID 6751400]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 19236486]; GO_process: GO:0000097 - sulfur amino acid biosynthetic process [Evidence IMP] [PMID 1479340]
AWJ20_245	Neurospora crassa e-Compendium ncu01765.3
AWJ20_246	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_248	Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 11967269]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA,IEA]; GO_function: GO:0003995 - acyl-CoA dehydrogenase activity [Evidence IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence IEA,IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence ISA] [PMID 2189786]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence IEA]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence ISA] [PMID 2189786]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_249	Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 11967269]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA,IEA]; GO_function: GO:0003995 - acyl-CoA dehydrogenase activity [Evidence IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence IEA,IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence ISA] [PMID 2189786]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence IEA]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence ISA] [PMID 2189786]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_251	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_253	Beta subunit of geranylgeranyltransferase type I; catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis; GO_component: GO:0005953 - CAAX-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 1400380]; GO_component: GO:0005622 - intracellular [Evidence TAS] [PMID 9891811]; GO_function: GO:0004662 - CAAX-protein geranylgeranyltransferase activity [Evidence IEA]; GO_function: GO:0004662 - CAAX-protein geranylgeranyltransferase activity [Evidence IDA] [PMID 1400380]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0004661 - protein geranylgeranyltransferase activity [Evidence IDA] [PMID 10066831]; GO_function: GO:0004661 - protein geranylgeranyltransferase activity [Evidence IDA] [PMID 2034682]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence TAS] [PMID 9891811]; GO_process: GO:0030010 - establishment of cell polarity [Evidence TAS] [PMID 9891811]; GO_process: GO:0018344 - protein geranylgeranylation [Evidence IDA] [PMID 2034682]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence TAS] [PMID 9891811]
AWJ20_255	Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15090619]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15090619]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA,IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IDA] [PMID 15766245]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034963 - box C/D snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0034964 - box H/ACA snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 17991894]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,IMP] [PMID 17158880]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 17991894]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 17991894]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 22576366]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IDA,IMP,IPI] [PMID 19818713]
AWJ20_256	Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 23207916]; GO_process: GO:0051983 - regulation of chromosome segregation [Evidence IMP] [PMID 23207916]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_257	Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008251 - tRNA-specific adenosine deaminase activity [Evidence IDA] [PMID 10550050]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 10550050]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_258	Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p and enters the nucleus under oxidative stress to promote transcription of stress response genes; human ortholog implicated in ALS; abundance increases under DNA replication stress and during exposure to boric acid; localization of a fraction to the mitochondrial intermembrane space is modulated by the MICOS complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11500508]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 11500508]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18977757]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24647101]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IBA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004784 - superoxide dismutase activity [Evidence IEA,IEA]; GO_function: GO:0004784 - superoxide dismutase activity [Evidence IDA] [PMID 3290902]; GO_function: GO:0008270 - zinc ion binding [Evidence IBA]; GO_process: GO:0001320 - age-dependent response to reactive oxygen species involved in chronological cell aging [Evidence IMP] [PMID 8647826]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 8530401]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 11581253]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 20176017]; GO_process: GO:1901856 - negative regulation of cellular respiration [Evidence IMP] [PMID 23332757]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0051091 - positive regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 18977757]; GO_process: GO:0036091 - positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [Evidence IMP] [PMID 24647101]; GO_process: GO:0050821 - protein stabilization [Evidence IMP,IPI] [PMID 23332757]; GO_process: GO:0019430 - removal of superoxide radicals [Evidence IBA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IEA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IMP] [PMID 3290902]
AWJ20_264	Cytoplasmic hypothetical protein; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_265	Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA,IPI] [PMID 12499356]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 9822583]; GO_component: GO:0005826 - actomyosin contractile ring [Evidence IBA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 9885246]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 9885246]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 9885246]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 18177206]; GO_process: GO:0007015 - actin filament organization [Evidence IMP,IPI] [PMID 9885246]; GO_process: GO:0007017 - microtubule-based process [Evidence IPI] [PMID 9885246]; GO_process: GO:0034316 - negative regulation of Arp2/3 complex-mediated actin nucleation [Evidence IDA,IMP] [PMID 12499356]; GO_process: GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation [Evidence IDA,IMP] [PMID 21454476]
AWJ20_266	Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IMP] [PMID 9675847]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006740 - NADPH regeneration [Evidence IGI] [PMID 19158096]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IGI] [PMID 10919763]; GO_process: GO:0006067 - ethanol metabolic process [Evidence IMP] [PMID 9675847]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 10409655]
AWJ20_268	Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15706032]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15706032]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004819 - glutamine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004819 - glutamine-tRNA ligase activity [Evidence IDA] [PMID 2991203]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006425 - glutaminyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006425 - glutaminyl-tRNA aminoacylation [Evidence IMP,ISS] [PMID 2991203]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
AWJ20_269	F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 9716410]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043224 - nuclear SCF ubiquitin ligase complex [Evidence IDA] [PMID 10637232]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10637232]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 15870262]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 15870262]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 9716410]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 9716410]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IGI,IPI] [PMID 9499404]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 15870262]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 15870262]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0046685 - response to arsenic-containing substance [Evidence IDA] [PMID 15689486]; GO_process: GO:0046686 - response to cadmium ion [Evidence IDA] [PMID 15689486]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_271	DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11565753]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 15028736]; GO_function: GO:0033680 - ATP-dependent DNA/RNA helicase activity [Evidence IDA] [PMID 15028736]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 15028736]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11565753]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_273	Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 10818358]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0047953 - glycerol 2-dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:1990042 - glycerol dehydrogenase [NAD(P)+] activity [Evidence IMP] [PMID 22979944]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_274	Suppressor of sphingoid LCB sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; GO_component: GO:0071944 - cell periphery [Evidence IDA] [PMID 24146988]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12034738]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 12034738]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12034738]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16407254]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IDA,ISS] [PMID 12034738]; GO_process: GO:0015908 - fatty acid transport [Evidence IDA] [PMID 12034738]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 15342785]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_275	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23651256]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence ISS] [PMID 10207060]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 23651256]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IEA]; GO_process: GO:0009074 - aromatic amino acid family catabolic process [Evidence IMP] [PMID 10207060]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10207060]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA]; GO_process: GO:0006572 - tyrosine catabolic process [Evidence IEA]
AWJ20_276	Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17710650]; GO_function: GO:0015144 - carbohydrate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015355 - secondary active monocarboxylate transmembrane transporter activity [Evidence IMP] [PMID 17710650]; GO_function: GO:0097079 - selenite:proton symporter activity [Evidence IMP] [PMID 20861301]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0034219 - carbohydrate transmembrane transport [Evidence IEA]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 10198029]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0006849 - plasma membrane pyruvate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0097080 - plasma membrane selenite transport [Evidence IMP] [PMID 20861301]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_278	Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17710650]; GO_function: GO:0015144 - carbohydrate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015355 - secondary active monocarboxylate transmembrane transporter activity [Evidence IMP] [PMID 17710650]; GO_function: GO:0097079 - selenite:proton symporter activity [Evidence IMP] [PMID 20861301]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0034219 - carbohydrate transmembrane transport [Evidence IEA]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 10198029]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0006849 - plasma membrane pyruvate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0097080 - plasma membrane selenite transport [Evidence IMP] [PMID 20861301]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_282	3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 3060034]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004604 - phosphoadenylyl-sulfate reductase (thioredoxin) activity [Evidence IEA,IEA]; GO_function: GO:0004604 - phosphoadenylyl-sulfate reductase (thioredoxin) activity [Evidence IMP] [PMID 2203779]; GO_function: GO:0004604 - phosphoadenylyl-sulfate reductase (thioredoxin) activity [Evidence IDA] [PMID 3060034]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IEA]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IMP] [PMID 197388]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IDA] [PMID 3060034]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IMP] [PMID 1101032]
AWJ20_283	Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA,IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 15485916]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 8406038]
AWJ20_284	Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS; GO_component: GO:0035649 - Nrd1 complex [Evidence IDA] [PMID 16427013]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23222640]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8544822]; GO_component: GO:0005657 - replication fork [Evidence IDA] [PMID 23141540]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence ISS] [PMID 10545196]; GO_function: GO:0032575 - ATP-dependent 5'-3' RNA helicase activity [Evidence ISS] [PMID 10545196]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence ISS] [PMID 10545196]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence ISS] [PMID 10545196]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0019904 - protein domain specific binding [Evidence IDA,IMP] [PMID 22286094]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23748379]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 11565036]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 22123738]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0045005 - maintenance of fidelity involved in DNA-dependent DNA replication [Evidence IMP] [PMID 23141540]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9365256]; GO_process: GO:1990248 - regulation of transcription from RNA polymerase II promoter in response to DNA damage [Evidence IMP] [PMID 23741394]; GO_process: GO:0016180 - snRNA processing [Evidence IMP] [PMID 9365256]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 11565036]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9365256]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 17157256]
AWJ20_285	Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,ISS] [PMID 10681558]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10821871]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA,IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP,ISS] [PMID 10681558]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA] [PMID 10821871]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 10681558]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0046686 - response to cadmium ion [Evidence IMP] [PMID 19332553]
AWJ20_288	Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence TAS] [PMID 11602261]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence TAS] [PMID 11602261]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0005979 - regulation of glycogen biosynthetic process [Evidence IGI] [PMID 11602261]; GO_process: GO:0005981 - regulation of glycogen catabolic process [Evidence IGI] [PMID 11602261]
AWJ20_289	Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10467108]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10467108]; GO_function: GO:0043531 - ADP binding [Evidence IMP] [PMID 11867765]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 11867765]; GO_function: GO:0042623 - ATPase activity, coupled [Evidence IDA,IMP] [PMID 16135516]; GO_function: GO:0042623 - ATPase activity, coupled [Evidence IMP] [PMID 9674429]; GO_function: GO:0051087 - chaperone binding [Evidence IDA] [PMID 9674429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16135516]; GO_process: GO:0070370 - cellular heat acclimation [Evidence IMP] [PMID 2188365]; GO_process: GO:0070389 - chaperone cofactor-dependent protein refolding [Evidence IDA] [PMID 9674429]; GO_process: GO:0001319 - inheritance of oxidatively modified proteins involved in replicative cell aging [Evidence IGI,IMP] [PMID 17908928]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IMP] [PMID 10931304]; GO_process: GO:0019538 - protein metabolic process [Evidence IEA]; GO_process: GO:0043335 - protein unfolding [Evidence IMP] [PMID 7984243]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0070414 - trehalose metabolism in response to heat stress [Evidence IMP] [PMID 9797333]
AWJ20_291	Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11238882]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17353896]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11238882]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16188229]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IEA]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 9891075]; GO_function: GO:0043022 - ribosome binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238882]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238882]; GO_process: GO:0042256 - mature ribosome assembly [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 17353896]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 10206977]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 11238882]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 15100437]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IEA]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IGI] [PMID 17353896]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
AWJ20_296	Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IDA] [PMID 11805111]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence ISS] [PMID 9164465]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IDA] [PMID 11805111]
AWJ20_299	hypothetical protein; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008198 - ferrous iron binding [Evidence IDA] [PMID 22367199]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 15485916]
AWJ20_300	RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IMP] [PMID 1409638]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 21263028]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 18160037]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IMP] [PMID 12374750]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IGI] [PMID 9121426]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_301	High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 16741702]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8594329]; GO_function: GO:0005352 - alpha-glucoside:proton symporter activity [Evidence IDA] [PMID 12702465]; GO_function: GO:0005364 - maltose:proton symporter activity [Evidence IMP] [PMID 1999393]; GO_function: GO:0005364 - maltose:proton symporter activity [Evidence IMP] [PMID 8594329]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015293 - symporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015574 - trehalose transmembrane transporter activity [Evidence IDA] [PMID 12702465]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0046352 - disaccharide catabolic process [Evidence IMP] [PMID 20562106]; GO_process: GO:0000023 - maltose metabolic process [Evidence IEA]; GO_process: GO:0015768 - maltose transport [Evidence IGI] [PMID 6371820]; GO_process: GO:0015768 - maltose transport [Evidence IMP] [PMID 8594329]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0015771 - trehalose transport [Evidence IDA] [PMID 12702465]
AWJ20_307	Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence IDA] [PMID 3031581]; GO_process: GO:0097056 - selenocysteinyl-tRNA(Sec) biosynthetic process [Evidence IEA]; GO_process: GO:0006434 - seryl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006434 - seryl-tRNA aminoacylation [Evidence IDA] [PMID 3031581]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_308	hypothetical protein; predicted to contain a PINc domain; ESL1 has a paralog, ESL2, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_310	Enzyme of the 'de novo' purine nucleotide biosynthetic pathway; contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004637 - phosphoribosylamine-glycine ligase activity [Evidence IEA,IEA]; GO_function: GO:0004637 - phosphoribosylamine-glycine ligase activity [Evidence ISS] [PMID 3097325]; GO_function: GO:0004641 - phosphoribosylformylglycinamidine cyclo-ligase activity [Evidence IEA,IEA]; GO_function: GO:0004641 - phosphoribosylformylglycinamidine cyclo-ligase activity [Evidence ISS] [PMID 3097325]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence TAS] [PMID 9148957]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]
AWJ20_311	Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, role in translational repression, mRNA decay, and processing body dynamics; may have a role in mRNA export; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12032091]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 12730603]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 18611963]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 20368989]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 12930949]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 23706738]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 11780629]; GO_function: GO:0090079 - translation regulator activity, nucleic acid binding [Evidence IGI,IMP] [PMID 22719226]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IMP] [PMID 18182159]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IGI] [PMID 18981231]; GO_process: GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA [Evidence IMP] [PMID 11780629]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0017148 - negative regulation of translation [Evidence IMP] [PMID 21844211]; GO_process: GO:0045900 - negative regulation of translational elongation [Evidence IGI,IMP] [PMID 22719226]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0034063 - stress granule assembly [Evidence IMP] [PMID 18981231]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_314	DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22367945]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 22367945]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 22367945]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_316	Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
AWJ20_317	Putative serine type carboxypeptidase; role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0017171 - serine hydrolase activity [Evidence IDA,ISM] [PMID 14645503]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence ISA] [PMID 17408619]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IGI] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_319	Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress; GO_component: GO:0030121 - AP-1 adaptor complex [Evidence IPI,ISS] [PMID 10564262]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IPI,ISS] [PMID 10564262]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 17003107]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IPI,ISS] [PMID 10564262]
AWJ20_320	G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 15340087]; GO_function: GO:0001965 - G-protein alpha-subunit binding [Evidence IPI] [PMID 17591772]; GO_function: GO:0005092 - GDP-dissociation inhibitor activity [Evidence IDA] [PMID 17591772]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 17591772]; GO_process: GO:0017148 - negative regulation of translation [Evidence IMP] [PMID 15340087]
AWJ20_321	Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8035833]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA,IMP] [PMID 8831696]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IGI,IMP] [PMID 10332043]; GO_process: GO:0006627 - protein processing involved in protein targeting to mitochondrion [Evidence IMP] [PMID 8035833]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 21525245]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_322	Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004356 - glutamate-ammonia ligase activity [Evidence IEA,IEA]; GO_function: GO:0004356 - glutamate-ammonia ligase activity [Evidence IMP] [PMID 1347768]; GO_function: GO:0004356 - glutamate-ammonia ligase activity [Evidence IDA] [PMID 4156034]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006542 - glutamine biosynthetic process [Evidence IEA]; GO_process: GO:0006542 - glutamine biosynthetic process [Evidence IDA] [PMID 6129248]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
AWJ20_323	PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IDA] [PMID 19158363]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 19158363]
AWJ20_324	Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 10817755]; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 17157260]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 10817755]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 11731478]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 11731479]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11731479]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 10817755]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_325	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004827 - proline-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004827 - proline-tRNA ligase activity [Evidence ISS] [PMID 10592175]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006433 - prolyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_326	Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IGI,IPI] [PMID 15024067]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 15024067]
AWJ20_327	Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 18086897]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 18086897]
AWJ20_328	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity [Evidence IDA] [PMID 2880280]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_329	Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005622 - intracellular [Evidence TAS] [PMID 8852895]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004359 - glutaminase activity [Evidence IDA] [PMID 10733892]; GO_function: GO:0000107 - imidazoleglycerol-phosphate synthase activity [Evidence IEA]; GO_function: GO:0000107 - imidazoleglycerol-phosphate synthase activity [Evidence IDA] [PMID 10733892]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016833 - oxo-acid-lyase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_330	NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000785 - chromatin [Evidence IDA] [PMID 17344218]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0010698 - acetyltransferase activator activity [Evidence IDA,IMP] [PMID 19172749]; GO_function: GO:0042393 - histone binding [Evidence IDA,IPI] [PMID 17344218]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IMP,IPI] [PMID 18036332]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 17344218]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IDA,IGI,IMP] [PMID 18458063]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_331	top hit is XP_007844384.1 originated in Moniliophthora roreri MCA 2997
AWJ20_334	Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich proteins and mediating their folding; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
AWJ20_336	Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9294463]; GO_function: GO:0000319 - sulfite transmembrane transporter activity [Evidence IDA] [PMID 10870099]; GO_process: GO:0000316 - sulfite transport [Evidence IDA] [PMID 10870099]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_338	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
AWJ20_339	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IBA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 14627813]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_340	Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004001 - adenosine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004001 - adenosine kinase activity [Evidence IDA,IMP] [PMID 11223943]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0044209 - AMP salvage [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IMP] [PMID 11223943]; GO_process: GO:0006166 - purine ribonucleoside salvage [Evidence IEA,IEA]
AWJ20_341	Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA,IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IDA] [PMID 10887197]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10887197]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003919 - FMN adenylyltransferase activity [Evidence IDA] [PMID 10887197]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008531 - riboflavin kinase activity [Evidence IEA,IEA]; GO_function: GO:0008531 - riboflavin kinase activity [Evidence IDA,IMP] [PMID 10887197]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009398 - FMN biosynthetic process [Evidence IEA]; GO_process: GO:0009398 - FMN biosynthetic process [Evidence IDA,IMP] [PMID 10887197]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA]
AWJ20_343	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_344	Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP); GO_component: GO:0030126 - COPI vesicle coat [Evidence IEA]; GO_component: GO:0030126 - COPI vesicle coat [Evidence IGI,ISS] [PMID 7929113]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0030135 - coated vesicle [Evidence ISS] [PMID 7929113]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 7929113]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
AWJ20_345	Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005685 - U1 snRNP [Evidence IEA]; GO_component: GO:0005685 - U1 snRNP [Evidence IGI,IMP] [PMID 10500099]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IMP] [PMID 17726058]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006376 - mRNA splice site selection [Evidence IEA]; GO_process: GO:0006376 - mRNA splice site selection [Evidence IGI,IMP] [PMID 10500099]
AWJ20_346	Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IMP] [PMID 9405463]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IPI] [PMID 9405463]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_348	Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0004409 - homoaconitate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0004409 - homoaconitate hydratase activity [Evidence ISA] [PMID 9268014]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 2507177]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_349	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IMP] [PMID 9524130]; GO_component: GO:0071021 - U2-type post-spliceosomal complex [Evidence IMP] [PMID 12212850]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 9582286]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IDA] [PMID 12212850]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 9524130]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IDA] [PMID 12212850]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 22408182]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000390 - spliceosomal complex disassembly [Evidence IMP] [PMID 9524130]
AWJ20_350	Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IDA] [PMID 12008673]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0043024 - ribosomal small subunit binding [Evidence IDA] [PMID 17434125]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 12008673]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 12861028]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 15145951]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IPI] [PMID 22851688]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 15664195]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 17434125]; GO_process: GO:1990145 - maintenance of translational fidelity [Evidence IMP] [PMID 9488467]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_351	Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0071561 - nucleus-vacuole junction [Evidence IDA] [PMID 22250200]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 22250200]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_353	Plasma membrane regulator of polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10545096]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 10545096]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10545096]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 23755272]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:1902274 - positive regulation of (R)-carnitine transmembrane transport [Evidence IMP] [PMID 23755272]; GO_process: GO:1902269 - positive regulation of polyamine transmembrane transport [Evidence IMP] [PMID 23755272]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_354	hypothetical protein required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IDA] [PMID 9497340]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 16564012]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0045471 - response to ethanol [Evidence IMP] [PMID 19416103]
AWJ20_355	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IGI] [PMID 15280369]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IMP] [PMID 10212224]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IGI] [PMID 15280369]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 15470112]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0009156 - ribonucleoside monophosphate biosynthetic process [Evidence IEA]
AWJ20_358	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005874 - microtubule [Evidence IEA,IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005827 - polar microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0043234 - protein complex [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_component: GO:0045298 - tubulin complex [Evidence IDA,IPI] [PMID 9488492]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0045143 - homologous chromosome segregation [Evidence IMP] [PMID 16582437]; GO_process: GO:0007017 - microtubule-based process [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 16582437]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 16582437]; GO_process: GO:0051258 - protein polymerization [Evidence IEA]
AWJ20_359	Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IMP] [PMID 15256563]; GO_process: GO:0006068 - ethanol catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_360	NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008106 - alcohol dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:0008106 - alcohol dehydrogenase (NADP+) activity [Evidence IDA] [PMID 11742541]; GO_function: GO:0033833 - hydroxymethylfurfural reductase (NADH) activity [Evidence IMP] [PMID 16652391]; GO_function: GO:0033845 - hydroxymethylfurfural reductase (NADPH) activity [Evidence IMP] [PMID 16652391]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006066 - alcohol metabolic process [Evidence IDA] [PMID 11742541]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence IDA] [PMID 11742541]; GO_process: GO:0033859 - furaldehyde metabolic process [Evidence IMP] [PMID 16652391]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_361	Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004340 - glucokinase activity [Evidence IEA]; GO_function: GO:0004340 - glucokinase activity [Evidence IMP] [PMID 6341351]; GO_function: GO:0004340 - glucokinase activity [Evidence IDA] [PMID 8501032]; GO_function: GO:0004396 - hexokinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA]; GO_process: GO:0051156 - glucose 6-phosphate metabolic process [Evidence IEA]; GO_process: GO:0046323 - glucose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IDA] [PMID 8501032]; GO_process: GO:0006013 - mannose metabolic process [Evidence IDA] [PMID 237183]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_362	Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12464632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA,IMP] [PMID 12464633]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA] [PMID 20385087]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IPI] [PMID 12464633]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IMP,IPI] [PMID 20385087]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 12464633]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17314407]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_363	Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 20797624]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 20797624]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10675505]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 20797624]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20797624]; GO_process: GO:0007155 - cell adhesion [Evidence IDA] [PMID 11816034]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 20797624]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IMP] [PMID 20797624]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 20797624]; GO_process: GO:0007009 - plasma membrane organization [Evidence IMP] [PMID 20797624]; GO_process: GO:0006950 - response to stress [Evidence IEA,IEA]
AWJ20_364	Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10799523]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10799523]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 19380492]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence ISA] [PMID 7568152]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 9106207]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IMP] [PMID 19380492]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IGI] [PMID 7568152]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0090294 - nitrogen catabolite activation of transcription [Evidence IGI,IMP] [PMID 7568152]; GO_process: GO:0090294 - nitrogen catabolite activation of transcription [Evidence IGI,IMP] [PMID 8622686]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 7568152]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_365	hypothetical protein; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9751732]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_366	Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005854 - nascent polypeptide-associated complex [Evidence IDA] [PMID 10219998]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 9482879]; GO_process: GO:0051083 - 'de novo' cotranslational protein folding [Evidence IPI] [PMID 10219998]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IGI] [PMID 10518932]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_367	Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004351 - glutamate decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004351 - glutamate decarboxylase activity [Evidence IMP] [PMID 11031268]; GO_function: GO:0016829 - lyase activity [Evidence IEA,IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11031268]; GO_process: GO:0006538 - glutamate catabolic process [Evidence IMP] [PMID 11031268]; GO_process: GO:0006536 - glutamate metabolic process [Evidence IEA]
AWJ20_368	Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 16611745]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19218424]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IDA] [PMID 12101234]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0016242 - negative regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 12101234]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0031647 - regulation of protein stability [Evidence IMP] [PMID 12101234]
AWJ20_369	Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12553664]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005543 - phospholipid binding [Evidence IDA] [PMID 12553664]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IGI,IMP,IPI] [PMID 12553664]
AWJ20_370	tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17652090]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 17652090]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0052906 - tRNA (guanine(37)-N(1))-methyltransferase activity [Evidence IEA]; GO_function: GO:0016423 - tRNA (guanine) methyltransferase activity [Evidence IGI,IMP,ISS] [PMID 11226173]; GO_function: GO:0009019 - tRNA (guanine-N1-)-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IEA,IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IGI,IMP,ISS] [PMID 11226173]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_371	Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 15355998]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 9873020]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA]
AWJ20_372	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA,IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8600032]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0071049 - nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [Evidence IGI] [PMID 11586364]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_375	Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10; GO_component: GO:0044695 - Dsc E3 ubiquitin ligase complex [Evidence IDA] [PMID 22681890]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_377	Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance; GO_component: GO:0031518 - CBF3 complex [Evidence IDA] [PMID 19882662]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11239005]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11239005]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0008534 - oxidized purine nucleobase lesion DNA N-glycosylase activity [Evidence IEA]; GO_function: GO:0008534 - oxidized purine nucleobase lesion DNA N-glycosylase activity [Evidence IDA] [PMID 8643552]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 11239005]; GO_process: GO:0006284 - base-excision repair [Evidence IEA]; GO_process: GO:0006285 - base-excision repair, AP site formation [Evidence IDA] [PMID 8643552]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IGI] [PMID 19264809]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 19942858]
AWJ20_378	Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern due to a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids; GO_component: GO:0070274 - RES complex [Evidence IDA] [PMID 15565172]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11452010]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 15565172]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 15565172]
AWJ20_382	Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence IEA,IEA]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence TAS] [PMID 9308367]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IEA]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IMP] [PMID 23597844]; GO_process: GO:0005991 - trehalose metabolic process [Evidence IEA]
AWJ20_383	hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_384	Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004132 - dCMP deaminase activity [Evidence IEA]; GO_function: GO:0004132 - dCMP deaminase activity [Evidence IMP] [PMID 3023902]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006231 - dTMP biosynthetic process [Evidence IMP] [PMID 6373725]; GO_process: GO:0006226 - dUMP biosynthetic process [Evidence IMP] [PMID 6373725]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA]
AWJ20_386	Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology by affecting lipid mixing in the mitochondrial membrane and by influencing the ratio of long to short forms of Mgm1p; partly exposed to the mitochondrial intermembrane space; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 23124206]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004609 - phosphatidylserine decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004609 - phosphatidylserine decarboxylase activity [Evidence IMP] [PMID 8407984]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA] [PMID 6427211]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0010636 - positive regulation of mitochondrial fusion [Evidence IMP] [PMID 23045528]; GO_process: GO:0010954 - positive regulation of protein processing [Evidence IMP] [PMID 23045528]
AWJ20_387	hypothetical protein with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_388	Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IEA]; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008054 - cyclin catabolic process [Evidence IMP] [PMID 8895471]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 8895471]; GO_process: GO:0007091 - metaphase/anaphase transition of mitotic cell cycle [Evidence IMP] [PMID 8895471]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 16481473]
AWJ20_390	Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0052904 - N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052903 - N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IMP] [PMID 11154694]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IDA] [PMID 21067138]; GO_function: GO:0052902 - spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052901 - spermine:oxygen oxidoreductase (spermidine-forming) activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006598 - polyamine catabolic process [Evidence IGI,IMP] [PMID 12586697]
AWJ20_392	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0031461 - cullin-RING ubiquitin ligase complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008054 - cyclin catabolic process [Evidence IMP] [PMID 9430641]; GO_process: GO:0010458 - exit from mitosis [Evidence IGI] [PMID 9430641]; GO_process: GO:0007091 - metaphase/anaphase transition of mitotic cell cycle [Evidence IGI] [PMID 9430641]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 16481473]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_394	Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 10760477]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000010 - trans-hexaprenyltranstransferase activity [Evidence IMP] [PMID 9708911]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9708911]
AWJ20_395	Cis-prenyltransferase involved in dolichol synthesis; major enzyme of polyprenol synthesis in both the endoplasmic reticulum (ER) and in lipid droplets; participates in ER protein sorting; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11442630]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 24868093]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9858571]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0045547 - dehydrodolichyl diphosphate synthase activity [Evidence IDA] [PMID 11442630]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IDA] [PMID 17345630]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IDA] [PMID 9858571]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 12911815]; GO_process: GO:0019408 - dolichol biosynthetic process [Evidence IDA] [PMID 10217761]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IDA,IMP] [PMID 9858571]
AWJ20_397	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 2277060]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_398	Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10825193]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10825193]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IDA] [PMID 7836422]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10991951]; GO_process: GO:0006405 - RNA export from nucleus [Evidence IMP] [PMID 7489726]; GO_process: GO:0046907 - intracellular transport [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 7489726]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 10991951]
AWJ20_399	Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10825193]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10825193]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IDA] [PMID 7836422]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10991951]; GO_process: GO:0006405 - RNA export from nucleus [Evidence IMP] [PMID 7489726]; GO_process: GO:0046907 - intracellular transport [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 7489726]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 10991951]
AWJ20_400	Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 8808631]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9312134]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0080129 - proteasome core complex assembly [Evidence IMP] [PMID 8808631]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
AWJ20_401	Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15620355]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15692568]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15466158]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15466158]; GO_component: GO:0005667 - transcription factor complex [Evidence IBA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003705 - RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_function: GO:0001225 - RNA polymerase II transcription coactivator binding [Evidence IPI] [PMID 15620355]; GO_function: GO:0001226 - RNA polymerase II transcription corepressor binding [Evidence IPI] [PMID 15620355]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IBA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0010688 - negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15620355]; GO_process: GO:0010688 - negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IGI] [PMID 7785326]; GO_process: GO:0060963 - positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 15616569]; GO_process: GO:0060963 - positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15620355]; GO_process: GO:0051090 - regulation of sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_402	Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15620355]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15692568]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15466158]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15466158]; GO_component: GO:0005667 - transcription factor complex [Evidence IBA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003705 - RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_function: GO:0001225 - RNA polymerase II transcription coactivator binding [Evidence IPI] [PMID 15620355]; GO_function: GO:0001226 - RNA polymerase II transcription corepressor binding [Evidence IPI] [PMID 15620355]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IBA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0010688 - negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15620355]; GO_process: GO:0010688 - negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IGI] [PMID 7785326]; GO_process: GO:0060963 - positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 15616569]; GO_process: GO:0060963 - positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15620355]; GO_process: GO:0051090 - regulation of sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_404	Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11747810]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 19129178]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 1918080]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11747810]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 1918080]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11914276]; GO_function: GO:0008061 - chitin binding [Evidence IEA]; GO_function: GO:0004568 - chitinase activity [Evidence IEA,IEA]; GO_function: GO:0008843 - endochitinase activity [Evidence IDA] [PMID 6799506]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IC] [PMID 3033651]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 1918080]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]
AWJ20_406	Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12960429]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9491896]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12960429]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17717527]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 7615633]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9491896]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000145 - exocyst [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 1512289]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 7615633]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9491896]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0048313 - Golgi inheritance [Evidence IMP] [PMID 15596717]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 15596717]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
AWJ20_408	top hit is XP_006683298.1 originated in Batrachochytrium dendrobatidis JAM81
AWJ20_411	Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 9774331]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 10777592]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IMP] [PMID 10777592]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IDA] [PMID 1898005]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016615 - malate dehydrogenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 3312168]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 18381895]; GO_process: GO:0006108 - malate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 18381895]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IMP] [PMID 3312168]
AWJ20_412	hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_413	Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane; GO_component: GO:0005780 - extrinsic component of intraperoxisomal membrane [Evidence IEA]; GO_component: GO:0005780 - extrinsic component of intraperoxisomal membrane [Evidence IDA] [PMID 15928207]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 14562095]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 23900285]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP] [PMID 23900285]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IEA]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IMP,IPI] [PMID 15928207]
AWJ20_414	Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005742 - mitochondrial outer membrane translocase complex [Evidence IDA] [PMID 9774667]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0046930 - pore complex [Evidence IEA]; GO_function: GO:0015288 - porin activity [Evidence IEA]; GO_function: GO:0015266 - protein channel activity [Evidence IEA]; GO_function: GO:0015266 - protein channel activity [Evidence IDA] [PMID 9774109]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 15590639]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_417	Subunit a of the vacuolar-ATPase V0 domain; one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11592965]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11948198]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11592965]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033179 - proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence IDA,ISS] [PMID 7514599]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IGI,ISS] [PMID 7514599]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IEP,IGI,IMP,ISS] [PMID 11278748]; GO_process: GO:0007035 - vacuolar acidification [Evidence IGI] [PMID 7514599]
AWJ20_418	Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9099739]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004410 - homocitrate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004410 - homocitrate synthase activity [Evidence ISS] [PMID 9099739]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0046912 - transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA,IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IGI,IMP] [PMID 18524920]
AWJ20_419	Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity; may have a role in ensuring that soluble TBP is available to bind TATA-less promoters; forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 11880621]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21976730]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9234740]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 22298788]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IPI] [PMID 8083216]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IMP] [PMID 24459134]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 17296733]; GO_process: GO:0045898 - regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 15861138]; GO_process: GO:0045898 - regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 21976730]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9234740]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IDA,IMP] [PMID 17296733]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_420	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IEA,IEA]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 11344258]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IEA,IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IDA] [PMID 11344258]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_423	hypothetical protein involved in calcium homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 23569283]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 23569283]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI,IMP] [PMID 23569283]
AWJ20_424	SET domain hypothetical protein; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA]
AWJ20_426	Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev7p, Pol31p and Pol32p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16452144]; GO_component: GO:0000790 - nuclear chromatin [Evidence IPI] [PMID 16546083]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0016035 - zeta DNA polymerase complex [Evidence IDA] [PMID 8658138]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 8658138]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 12514101]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 11313481]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 17248528]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 9765213]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]
AWJ20_427	Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev7p, Pol31p and Pol32p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16452144]; GO_component: GO:0000790 - nuclear chromatin [Evidence IPI] [PMID 16546083]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0016035 - zeta DNA polymerase complex [Evidence IDA] [PMID 8658138]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 8658138]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 12514101]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 11313481]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 17248528]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 9765213]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]
AWJ20_428	Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability; GO_component: GO:0032390 - MutLbeta complex [Evidence IEA]; GO_component: GO:0097587 - MutLgamma complex [Evidence IPI] [PMID 9770499]; GO_component: GO:0005712 - chiasma [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10570173]; GO_component: GO:0000795 - synaptonemal complex [Evidence IBA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IBA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 23316435]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IBA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 23316435]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 10679328]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 9770499]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10570173]
AWJ20_429	Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_430	Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 7891656]; GO_function: GO:0015218 - pyrimidine nucleotide transmembrane transporter activity [Evidence IDA] [PMID 16194150]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 7891656]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 7891656]; GO_process: GO:0006864 - pyrimidine nucleotide transport [Evidence IDA] [PMID 16194150]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 16194150]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_431	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0031497 - chromatin assembly [Evidence IMP] [PMID 12399376]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 16481473]
AWJ20_433	Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_439	Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 16002643]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 16624861]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16002643]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0071782 - endoplasmic reticulum tubular network [Evidence IDA] [PMID 16469703]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 16624861]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IGI] [PMID 19665976]; GO_process: GO:0071788 - endoplasmic reticulum tubular network maintenance [Evidence IGI] [PMID 21502358]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IGI,IMP] [PMID 16469703]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IMP] [PMID 16624861]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IGI] [PMID 18309084]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IGI] [PMID 18442980]; GO_process: GO:0071786 - endoplasmic reticulum tubular network organization [Evidence IGI,IPI] [PMID 19665976]; GO_process: GO:0051292 - nuclear pore complex assembly [Evidence IGI] [PMID 19273614]
AWJ20_440	Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10397764]; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11302750]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0005543 - phospholipid binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IGI,IPI] [PMID 14704157]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10397764]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 10652251]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8380177]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence TAS] [PMID 10652251]
AWJ20_441	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10806210]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IDA] [PMID 10806210]; GO_function: GO:0008311 - double-stranded DNA 3'-5' exodeoxyribonuclease activity [Evidence IDA] [PMID 11238902]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IDA] [PMID 11238902]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IGI] [PMID 9765213]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_443	Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 15306853]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IDA] [PMID 23509072]; GO_function: GO:0045182 - translation regulator activity [Evidence IMP] [PMID 19710419]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0097034 - mitochondrial respiratory chain complex IV biogenesis [Evidence IMP] [PMID 15306853]; GO_process: GO:0070131 - positive regulation of mitochondrial translation [Evidence IGI,IMP,IPI] [PMID 15306853]; GO_process: GO:0070131 - positive regulation of mitochondrial translation [Evidence IMP] [PMID 19710419]
AWJ20_444	Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9271392]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 9271392]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IGI,IMP] [PMID 9271392]
AWJ20_445	Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004746 - riboflavin synthase activity [Evidence IEA,IEA]; GO_function: GO:0004746 - riboflavin synthase activity [Evidence IDA,ISS] [PMID 7814407]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 7814407]
AWJ20_449	Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11452019]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030684 - preribosome [Evidence IDA] [PMID 17922018]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 11452019]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_451	Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12676688]; GO_function: GO:0008732 - L-allo-threonine aldolase activity [Evidence IDA] [PMID 9151955]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA,IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0004793 - threonine aldolase activity [Evidence IDA] [PMID 9163906]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IEA]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IDA] [PMID 3086094]; GO_process: GO:0006567 - threonine catabolic process [Evidence IDA] [PMID 3086094]
AWJ20_460	Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8391780]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8391780]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IDA,IGI] [PMID 1333436]; GO_function: GO:0004127 - cytidylate kinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0019205 - nucleobase-containing compound kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0019201 - nucleotide kinase activity [Evidence IEA]; GO_function: GO:0016776 - phosphotransferase activity, phosphate group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0009041 - uridylate kinase activity [Evidence IDA,IMP] [PMID 1655742]; GO_function: GO:0009041 - uridylate kinase activity [Evidence IDA] [PMID 2549068]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IDA] [PMID 8391780]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IDA] [PMID 2549068]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA]
AWJ20_461	Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 10449419]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 11720284]
AWJ20_463	Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10871363]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IPI] [PMID 16095611]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IGI,IPI] [PMID 16803892]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 10077188]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10871363]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10871363]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_465	Non-ATPase regulatory subunit of the 26S proteasome; similar to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 10490597]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 10490597]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 10490597]
AWJ20_467	Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15387819]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IEA]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IDA] [PMID 15387819]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IGI,ISS] [PMID 15387819]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_468	Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11864606]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 11864607]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IPI] [PMID 11864606]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11864606]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11864606]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 11864607]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 16581791]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_470	Lysine-specific metalloprotease of the pitrilysin family; metalloprotease of the intermembrane space; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 15772085]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15606766]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 15606766]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IMP] [PMID 15772085]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IDA] [PMID 15606766]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IMP] [PMID 15772085]
AWJ20_471	Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17020589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10485850]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10545454]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17020589]; GO_function: GO:0008262 - importin-alpha export receptor activity [Evidence IDA] [PMID 9214382]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12697814]; GO_process: GO:0006611 - protein export from nucleus [Evidence IDA] [PMID 12697814]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 23716718]; GO_process: GO:0006611 - protein export from nucleus [Evidence IDA] [PMID 9853758]; GO_process: GO:0071528 - tRNA re-export from nucleus [Evidence IGI] [PMID 20032305]
AWJ20_472	NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003958 - NADPH-hemoprotein reductase activity [Evidence IEA,IEA]; GO_function: GO:0003958 - NADPH-hemoprotein reductase activity [Evidence IDA] [PMID 9087488]; GO_function: GO:0009055 - electron carrier activity [Evidence IDA] [PMID 11485306]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 9468503]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_475	Protein that recognizes and binds damaged DNA (with Rad23p) during NER; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins; NER stands for nucleotide excision repair; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19889839]; GO_component: GO:0000111 - nucleotide-excision repair factor 2 complex [Evidence IDA] [PMID 7768886]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19889839]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9813069]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9837874]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 18936173]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 19889839]
AWJ20_476	ER membrane protein involved in a late step of GPI anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated glycosylphosphatidylinositol (GPI) intermediate; human PIG-Fp is a functional homolog; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence ISS] [PMID 10793139]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 10793139]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 10793139]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 10793139]
AWJ20_477	RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 10523662]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9099738]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 12145212]
AWJ20_478	RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 10523662]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9099738]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 12145212]
AWJ20_479	Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 15082763]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence ISS] [PMID 15082763]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 18617998]; GO_process: GO:0044419 - interspecies interaction between organisms [Evidence IMP] [PMID 7532890]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_480	conserved hypothetical protein, similar to Fe II, 2-oxoglutarate-dependent dioxygenases; allele of CaO19.1306
AWJ20_481	Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10428783]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0034658 - isopropylmalate transmembrane transporter activity [Evidence IDA] [PMID 18682385]; GO_function: GO:1901239 - malonate(1-) transmembrane transporter activity [Evidence IDA] [PMID 10428783]; GO_function: GO:0015131 - oxaloacetate transmembrane transporter activity [Evidence IDA] [PMID 10428783]; GO_function: GO:0015116 - sulfate transmembrane transporter activity [Evidence IDA] [PMID 10428783]; GO_process: GO:0034659 - isopropylmalate transport [Evidence IDA] [PMID 18682385]; GO_process: GO:0015729 - oxaloacetate transport [Evidence IDA] [PMID 10428783]; GO_process: GO:0008272 - sulfate transport [Evidence IDA] [PMID 10428783]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_482	MYND domain-containing protein; required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA,IMP] [PMID 18070918]; GO_process: GO:0007116 - regulation of cell budding [Evidence IMP,ISS] [PMID 9427754]
AWJ20_484	Mucin family member that functions as an osmosensor in the HOG pathway; functions in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,ISS] [PMID 8550469]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 17627274]; GO_function: GO:0005034 - osmosensor activity [Evidence IGI] [PMID 17627274]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 8550469]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 8550469]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 8550469]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 17627274]; GO_process: GO:0007232 - osmosensory signaling pathway via Sho1 osmosensor [Evidence IGI,IPI] [PMID 17627274]
AWJ20_487	Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 2509432]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IMP] [PMID 7851411]; GO_function: GO:0008061 - chitin binding [Evidence IEA]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence IDA] [PMID 8458852]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16986442]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_490	Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA,IMP] [PMID 11566881]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 16862600]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0000298 - endopolyphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0000298 - endopolyphosphatase activity [Evidence IDA,IMP] [PMID 11447286]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IEA]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IMP] [PMID 16862600]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IDA] [PMID 17009950]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006798 - polyphosphate catabolic process [Evidence IDA] [PMID 17009950]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IDA,IMP] [PMID 11447286]
AWJ20_493	Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8045256]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12374868]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 7679674]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 7679674]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 11389139]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 8626301]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0000770 - peptide pheromone export [Evidence IMP] [PMID 2569166]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_495	Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_496	Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IDA] [PMID 16675952]; GO_component: GO:0000113 - nucleotide-excision repair factor 4 complex [Evidence IDA] [PMID 9497356]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 9497356]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9497356]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16675952]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000715 - nucleotide-excision repair, DNA damage recognition [Evidence IDA,IMP] [PMID 15177043]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16675952]
AWJ20_497	Vacuolar glutathione S-conjugate transporter; member of ATP-binding cassette family; ATPase activity required to support vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; has role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23658021]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8692889]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0015127 - bilirubin transmembrane transporter activity [Evidence IGI,IMP] [PMID 10790694]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 10220408]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12383937]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12755704]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 9217966]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015723 - bilirubin transport [Evidence IGI,IMP] [PMID 10790694]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046686 - response to cadmium ion [Evidence IEA]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 10220408]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 12755704]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 9217966]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 10790694]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 23658021]
AWJ20_498	G protein beta subunit; forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IMP] [PMID 2105453]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IDA] [PMID 8995254]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 11073983]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8995254]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP] [PMID 2107073]; GO_process: GO:0031684 - heterotrimeric G-protein complex cycle [Evidence IMP] [PMID 2107073]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 15192700]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI,IPI] [PMID 10087263]; GO_process: GO:0010525 - regulation of transposition, RNA-mediated [Evidence IMP] [PMID 9566871]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_499	Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 12408816]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19144819]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0017016 - Ras GTPase binding [Evidence ISS] [PMID 17303383]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 19144819]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP,IPI] [PMID 12408816]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 12408816]; GO_process: GO:0046580 - negative regulation of Ras protein signal transduction [Evidence ISS] [PMID 17303383]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]
AWJ20_500	Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 14697254]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 14697254]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_501	Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 14697254]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 14697254]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_502	Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 20182505]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0090156 - cellular sphingolipid homeostasis [Evidence IMP] [PMID 20182505]; GO_process: GO:0090155 - negative regulation of sphingolipid biosynthetic process [Evidence IGI,IMP,IPI] [PMID 20182505]; GO_process: GO:0006986 - response to unfolded protein [Evidence IMP,ISS] [PMID 12093374]
AWJ20_503	Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IMP] [PMID 19806183]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_504	Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10402465]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10402465]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IDA] [PMID 16390997]; GO_function: GO:0000149 - SNARE binding [Evidence IPI] [PMID 15964280]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IPI] [PMID 10402465]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IPI] [PMID 15964280]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 10402465]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IPI] [PMID 16390997]
AWJ20_505	DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; GO_component: GO:0032807 - DNA ligase IV complex [Evidence IPI] [PMID 17567543]; GO_component: GO:0000790 - nuclear chromatin [Evidence IPI] [PMID 10679327]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA] [PMID 9242411]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA,IMP] [PMID 9271115]; GO_function: GO:0003909 - DNA ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006266 - DNA ligation [Evidence IBA]; GO_process: GO:0051103 - DNA ligation involved in DNA repair [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA] [PMID 15342630]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IMP] [PMID 9242411]; GO_process: GO:0001302 - replicative cell aging [Evidence IGI] [PMID 18627461]
AWJ20_506	DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; GO_component: GO:0032807 - DNA ligase IV complex [Evidence IPI] [PMID 17567543]; GO_component: GO:0000790 - nuclear chromatin [Evidence IPI] [PMID 10679327]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA] [PMID 9242411]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA,IMP] [PMID 9271115]; GO_function: GO:0003909 - DNA ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006266 - DNA ligation [Evidence IBA]; GO_process: GO:0051103 - DNA ligation involved in DNA repair [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA] [PMID 15342630]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IMP] [PMID 9242411]; GO_process: GO:0001302 - replicative cell aging [Evidence IGI] [PMID 18627461]
AWJ20_507	Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_510	hypothetical protein; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21777356]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21777356]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004121 - cystathionine beta-lyase activity [Evidence ISS] [PMID 10821189]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence ISS] [PMID 10821189]
AWJ20_511	Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19797078]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19797079]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 19797079]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 19797079]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0070180 - large ribosomal subunit rRNA binding [Evidence ISA] [PMID 19346338]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 10471698]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IGI,IMP] [PMID 19797079]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
AWJ20_513	Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 2189783]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0004845 - uracil phosphoribosyltransferase activity [Evidence IEA]; GO_function: GO:0004845 - uracil phosphoribosyltransferase activity [Evidence IDA] [PMID 2189783]; GO_process: GO:0044206 - UMP salvage [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008655 - pyrimidine-containing compound salvage [Evidence IDA] [PMID 2189783]
AWJ20_514	hypothetical protein; mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 11816027]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_516	Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IMP] [PMID 9675847]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006740 - NADPH regeneration [Evidence IGI] [PMID 19158096]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IGI] [PMID 10919763]; GO_process: GO:0006067 - ethanol metabolic process [Evidence IMP] [PMID 9675847]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 10409655]
AWJ20_518	Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control; GO_component: GO:0005948 - acetolactate synthase complex [Evidence IDA] [PMID 10213630]; GO_component: GO:0005948 - acetolactate synthase complex [Evidence ISS] [PMID 2989783]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence IDA] [PMID 10213630]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence ISS] [PMID 2989783]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IDA] [PMID 15709745]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IDA,IMP] [PMID 2406721]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
AWJ20_520	Splicing factor; component of the U4/U6-U5 snRNP complex; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA,IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 8202378]
AWJ20_521	Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; relocalizes to the cytosol in response to hypoxia; similar to Hda2p; GO_component: GO:0070823 - HDA1 complex [Evidence IEA]; GO_component: GO:0070823 - HDA1 complex [Evidence IDA,IPI] [PMID 11287668]; GO_component: GO:0070823 - HDA1 complex [Evidence IDA] [PMID 8663039]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 19573535]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16415367]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IEA]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IDA] [PMID 19573535]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 16415367]; GO_process: GO:0031047 - gene silencing by RNA [Evidence IMP] [PMID 18022365]; GO_process: GO:0010978 - gene silencing involved in chronological cell aging [Evidence IMP] [PMID 18022365]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA,IMP] [PMID 11287668]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA,IMP] [PMID 8663039]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11287668]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_522	Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0031510 - SUMO activating enzyme complex [Evidence IPI] [PMID 9312010]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0019948 - SUMO activating enzyme activity [Evidence IDA] [PMID 9312010]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016925 - protein sumoylation [Evidence IDA] [PMID 9312010]
AWJ20_523	GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p; GO_component: GO:0030127 - COPII vesicle coat [Evidence IEA]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA] [PMID 8451644]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0003400 - regulation of COPII vesicle coating [Evidence IDA] [PMID 8451644]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_527	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IBA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_528	Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 17640275]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22792405]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 17640275]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 17640275]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 17640275]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 17640275]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 17640275]; GO_process: GO:0003400 - regulation of COPII vesicle coating [Evidence IDA,IMP,IPI] [PMID 22792405]
AWJ20_529	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_531	Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11381092]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 16601683]; GO_process: GO:0007007 - inner mitochondrial membrane organization [Evidence IDA] [PMID 11381092]; GO_process: GO:0097033 - mitochondrial respiratory chain complex III biogenesis [Evidence IGI,IMP] [PMID 20427570]; GO_process: GO:0097034 - mitochondrial respiratory chain complex IV biogenesis [Evidence IGI,IMP] [PMID 20427570]; GO_process: GO:0070131 - positive regulation of mitochondrial translation [Evidence IGI] [PMID 20427570]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 16601683]
AWJ20_532	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 3316985]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 18552279]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 14597621]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 14993234]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9442111]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IMP] [PMID 10882120]; GO_process: GO:0045860 - positive regulation of protein kinase activity [Evidence IDA] [PMID 14527412]; GO_process: GO:0000921 - septin ring assembly [Evidence IDA] [PMID 12636916]; GO_process: GO:0000921 - septin ring assembly [Evidence IMP] [PMID 14993234]
AWJ20_533	Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 8524252]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 11046133]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 8524252]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_534	Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein; GO_component: GO:0000417 - HIR complex [Evidence IDA,IPI] [PMID 16264190]; GO_component: GO:0000417 - HIR complex [Evidence IDA] [PMID 16303565]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9001207]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16264190]; GO_function: GO:0031491 - nucleosome binding [Evidence IMP] [PMID 16264190]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IMP] [PMID 9001207]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16264190]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16303565]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 1406694]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 16449659]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_536	Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7860598]; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 12689631]; GO_component: GO:0005759 - mitochondrial matrix [Evidence TAS] [PMID 12689631]; GO_component: GO:0005886 - plasma membrane [Evidence TAS] [PMID 12689631]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IEA]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IDA] [PMID 17215253]; GO_function: GO:0004309 - exopolyphosphatase activity [Evidence IDA,IMP] [PMID 7860598]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016462 - pyrophosphatase activity [Evidence IEA]; GO_process: GO:0006798 - polyphosphate catabolic process [Evidence IMP] [PMID 7860598]; GO_process: GO:0006798 - polyphosphate catabolic process [Evidence IDA] [PMID 8157625]
AWJ20_537	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004412 - homoserine dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004412 - homoserine dehydrogenase activity [Evidence IDA] [PMID 11341915]; GO_function: GO:0004412 - homoserine dehydrogenase activity [Evidence ISS] [PMID 8500624]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0009090 - homoserine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 4380684]
AWJ20_538	Phosphorelay intermediate protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14665464]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14665464]; GO_function: GO:0043424 - protein histidine kinase binding [Evidence IPI] [PMID 8808622]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IDA] [PMID 8808622]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA,IMP] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]
AWJ20_539	Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 16251400]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 11459965]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 16251400]; GO_function: GO:0043130 - ubiquitin binding [Evidence ISS] [PMID 17550899]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0033567 - DNA replication, Okazaki fragment processing [Evidence IDA] [PMID 16251400]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 11459965]; GO_process: GO:0006952 - defense response [Evidence IEA]; GO_process: GO:0006282 - regulation of DNA repair [Evidence IGI] [PMID 16809783]
AWJ20_540	GTPase-activating protein (GAP), subunit of SEA and Iml1p complexes; SEA (Seh1-associated) complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; localized to either pre-autophagosomal structures (PAS) or non-PAS structures during NNS-induced autophagy; GO_component: GO:1990130 - Iml1 complex [Evidence IDA] [PMID 21900499]; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA,IMP,IPI] [PMID 23716719]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:2000785 - regulation of autophagic vacuole assembly [Evidence IMP] [PMID 21900499]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_541	hypothetical protein; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence ISS] [PMID 10618406]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
AWJ20_542	Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,ISS] [PMID 10445034]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_544	COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IDA] [PMID 7593161]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0070971 - endoplasmic reticulum exit site [Evidence IDA] [PMID 22675024]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0043495 - protein anchor [Evidence IDA] [PMID 12235121]; GO_function: GO:0043495 - protein anchor [Evidence IDA] [PMID 7593161]; GO_process: GO:0048208 - COPII vesicle coating [Evidence IEA]; GO_process: GO:0048208 - COPII vesicle coating [Evidence IDA] [PMID 12235121]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0070973 - protein localization to endoplasmic reticulum exit site [Evidence IMP] [PMID 22675024]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_545	COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IDA] [PMID 7593161]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0070971 - endoplasmic reticulum exit site [Evidence IDA] [PMID 22675024]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0043495 - protein anchor [Evidence IDA] [PMID 12235121]; GO_function: GO:0043495 - protein anchor [Evidence IDA] [PMID 7593161]; GO_process: GO:0048208 - COPII vesicle coating [Evidence IEA]; GO_process: GO:0048208 - COPII vesicle coating [Evidence IDA] [PMID 12235121]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0070973 - protein localization to endoplasmic reticulum exit site [Evidence IMP] [PMID 22675024]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_547	RNA polymerase subunit AC40; common to RNA polymerase I and III; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_548	top hit is XP_003029647.1 originated in Schizophyllum commune H4-8
AWJ20_549	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 2648398]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence IGI] [PMID 10409745]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence IGI,ISS] [PMID 2648398]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 9841679]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA,IMP] [PMID 1502180]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 24471916]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA,IMP] [PMID 1502180]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 2648398]; GO_function: GO:0003743 - translation initiation factor activity [Evidence TAS] [PMID 9841679]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence ISS] [PMID 2648398]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA,IMP] [PMID 1502180]
AWJ20_551	Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 21343297]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0005775 - vacuolar lumen [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IDA] [PMID 16367759]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence ISS] [PMID 15606766]; GO_process: GO:0006508 - proteolysis [Evidence ISS] [PMID 8091229]
AWJ20_555	ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003951 - NAD+ kinase activity [Evidence IEA]; GO_function: GO:0003951 - NAD+ kinase activity [Evidence IDA] [PMID 15978040]; GO_function: GO:0042736 - NADH kinase activity [Evidence IEA]; GO_function: GO:0042736 - NADH kinase activity [Evidence IDA] [PMID 15978040]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019674 - NAD metabolic process [Evidence IEA]; GO_process: GO:0006741 - NADP biosynthetic process [Evidence IEA]; GO_process: GO:0006741 - NADP biosynthetic process [Evidence IDA] [PMID 15978040]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_556	Protein required for pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22083961]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 23175604]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22083961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8582632]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IPI] [PMID 23175604]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 23175604]; GO_process: GO:0000460 - maturation of 5.8S rRNA [Evidence IMP] [PMID 22083961]; GO_process: GO:0000470 - maturation of LSU-rRNA [Evidence IMP] [PMID 22083961]
AWJ20_557	Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10866670]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18952899]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18952899]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004335 - galactokinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 8628318]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA]; GO_process: GO:0006012 - galactose metabolic process [Evidence IEA,IEA]; GO_process: GO:0006012 - galactose metabolic process [Evidence IMP] [PMID 4577139]; GO_process: GO:0045185 - maintenance of protein location [Evidence IMP] [PMID 19651897]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000435 - positive regulation of transcription from RNA polymerase II promoter by galactose [Evidence IMP] [PMID 3013721]
AWJ20_558	alpha-arrestin involved in ubiquitin-dependent endocytosis; regulates endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; involved in basal internalization and turnover of alpha-factor receptor Ste2p and recovery from pheromone induced G1 arrest; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 22118465]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22118465]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22118465]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IPI] [PMID 18976803]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence IMP,IPI] [PMID 18976803]
AWJ20_559	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_560	Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR2 has a paralog, CPR5, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0042277 - peptide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 1761234]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]
AWJ20_562	Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 17157260]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 17157260]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_564	Central component of the peroxisomal protein import machinery; peroxisomal membrane peroxin; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA,IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 9094717]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 9312008]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 9094717]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 9312008]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IEA]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IMP,IPI] [PMID 16107331]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 9094717]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 9312008]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_567	E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0042292 - URM1 activating enzyme activity [Evidence IDA,ISS] [PMID 10713047]; GO_function: GO:0042292 - URM1 activating enzyme activity [Evidence IMP] [PMID 14555475]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0070733 - protein adenylyltransferase activity [Evidence IMP] [PMID 19145231]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IEA]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IDA] [PMID 18491921]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IMP] [PMID 19145231]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IDA] [PMID 19864628]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0007114 - cell budding [Evidence IGI] [PMID 14551258]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 14555475]; GO_process: GO:0018192 - enzyme active site formation via L-cysteine persulfide [Evidence IEA]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IGI,IMP] [PMID 14551258]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IDA] [PMID 10713047]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14555475]; GO_process: GO:2000220 - regulation of pseudohyphal growth [Evidence IMP] [PMID 22043304]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IEA]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 18664566]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19145231]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19151091]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IEA]
AWJ20_570	Subunit of the SF3a splicing factor complex; required for spliceosome assembly; GO_component: GO:0005686 - U2 snRNP [Evidence TAS] [PMID 11804584]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 8065365]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 8969185]
AWJ20_571	Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 20850366]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IDA] [PMID 20850366]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 12482202]
AWJ20_577	Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19416370]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 23393135]; GO_function: GO:0001042 - RNA polymerase I core binding [Evidence IDA,IPI] [PMID 11032814]; GO_function: GO:0001179 - RNA polymerase I transcription factor binding [Evidence IDA,IPI] [PMID 11032814]; GO_function: GO:0001082 - RNA polymerase I transcription factor binding transcription factor activity [Evidence IDA,IGI,IPI] [PMID 11032814]; GO_function: GO:0001181 - core RNA polymerase I binding transcription factor activity [Evidence IDA,IGI,IPI] [PMID 11032814]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001180 - transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript [Evidence IMP] [PMID 8670901]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_581	Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals; GO_component: GO:0030122 - AP-2 adaptor complex [Evidence IPI] [PMID 10564262]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 24460703]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IC] [PMID 10564262]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_583	SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0035241 - protein-arginine omega-N monomethyltransferase activity [Evidence IDA] [PMID 22650761]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IMP] [PMID 22650761]
AWJ20_584	Putative acyltransferase with similarity to Eeb1p and Eht1p; has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence ISS] [PMID 16361250]; GO_process: GO:0051792 - medium-chain fatty acid biosynthetic process [Evidence IGI] [PMID 16361250]
AWJ20_588	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_597	similar to Aspergillus terreus NIH2624 XP_001208692.1
AWJ20_598	NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11921099]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IGI,ISS] [PMID 11921099]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 21246355]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 11921099]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 19564482]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_599	NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11921099]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IGI,ISS] [PMID 11921099]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 21246355]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 11921099]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 19564482]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_600	GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog, RGA2, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0032177 - cellular bud neck split septin rings [Evidence IDA] [PMID 18166650]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 12455995]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 17981141]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 18166650]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IGI,IPI] [PMID 7498791]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 8657111]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IPI] [PMID 10066831]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence IPI] [PMID 10066831]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 18166650]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IPI] [PMID 10066831]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI] [PMID 7498791]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IPI] [PMID 10066831]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0031106 - septin ring organization [Evidence IGI] [PMID 14517318]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_604	Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9727014]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015039 - NADPH-adrenodoxin reductase activity [Evidence IDA] [PMID 9727014]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 11035018]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 20534343]
AWJ20_609	DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis; GO_component: GO:0032300 - mismatch repair complex [Evidence IBA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15611870]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 7961998]; GO_component: GO:0000228 - nuclear chromosome [Evidence IRD]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 7961999]; GO_function: GO:0003684 - damaged DNA binding [Evidence IBA]; GO_function: GO:0032139 - dinucleotide insertion or deletion binding [Evidence IDA] [PMID 7961998]; GO_function: GO:0032137 - guanine/thymine mispair binding [Evidence IDA] [PMID 7961998]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IRD]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 1334021]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IRD]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IRD]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 15611870]; GO_process: GO:0043504 - mitochondrial DNA repair [Evidence IMP] [PMID 1334021]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 1334021]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 1334021]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 15611870]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 15590333]
AWJ20_610	RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 12242285]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 12515383]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12515383]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 12515383]; GO_process: GO:0000493 - box H/ACA snoRNP assembly [Evidence IMP,IPI] [PMID 12228251]; GO_process: GO:0000493 - box H/ACA snoRNP assembly [Evidence IMP] [PMID 12242285]; GO_process: GO:0000493 - box H/ACA snoRNP assembly [Evidence IMP,IPI] [PMID 12515383]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
AWJ20_612	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_617	Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1703236]; GO_function: GO:0005381 - iron ion transmembrane transporter activity [Evidence IMP] [PMID 12902335]; GO_process: GO:0008380 - RNA splicing [Evidence IGI] [PMID 2448588]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0048250 - mitochondrial iron ion transport [Evidence IDA] [PMID 12902335]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_618	Protein required for biogenesis of the small ribosomal subunit; required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; essential gene; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 12150911]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]
AWJ20_620	Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 10028181]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 11935221]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004650 - polygalacturonase activity [Evidence IEA,IEA]; GO_function: GO:0004650 - polygalacturonase activity [Evidence IDA] [PMID 10650215]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045490 - pectin catabolic process [Evidence IDA] [PMID 10028181]; GO_process: GO:0007124 - pseudohyphal growth [Evidence NAS] [PMID 11255250]
AWJ20_621	RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19127978]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17030511]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19127978]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA,IMP] [PMID 19127978]; GO_process: GO:0071032 - nuclear mRNA surveillance of mRNP export [Evidence IMP] [PMID 19127978]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IGI,IMP,IPI] [PMID 17030511]
AWJ20_624	Protein that recognizes and binds damaged DNA (with Rad23p) during NER; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins; NER stands for nucleotide excision repair; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19889839]; GO_component: GO:0000111 - nucleotide-excision repair factor 2 complex [Evidence IDA] [PMID 7768886]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19889839]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9813069]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9837874]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 18936173]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 19889839]
AWJ20_625	Alpha-arrestin family member; activation through a switch in its modification state relays glucose signaling to transporter endocytosis; contributes to desensitization of agonist-occupied Ste2p by Rsp5p-dependent internalization and to recovery from pheromone induced G1 arrest; interacts with ubiquitin ligase Rsp5p via its 2 PY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8621680]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IPI] [PMID 18976803]; GO_process: GO:0042493 - response to drug [Evidence IMP] [PMID 12163175]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence ISA] [PMID 18976803]
AWJ20_626	Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015297 - antiporter activity [Evidence ISS] [PMID 12603313]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006556 - S-adenosylmethionine biosynthetic process [Evidence IMP] [PMID 18592490]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 12603313]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_627	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IEA]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 11370741]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008022 - protein C-terminus binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12667447]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 19687296]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 22471590]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 11370741]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 15536088]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 9090384]; GO_process: GO:0006625 - protein targeting to peroxisome [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_629	1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence ISS] [PMID 10769178]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 17397106]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IGI,IMP] [PMID 17189486]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]
AWJ20_630	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_631	Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0046526 - D-xylulose reductase activity [Evidence IEA]; GO_function: GO:0046526 - D-xylulose reductase activity [Evidence IDA] [PMID 10486580]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0042732 - D-xylose metabolic process [Evidence IEA]; GO_process: GO:0019569 - L-arabinose catabolic process to xylulose 5-phosphate [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0005999 - xylulose biosynthetic process [Evidence IDA,IEP] [PMID 10486580]
AWJ20_634	Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 9624054]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 21335519]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IMP,ISS] [PMID 12471154]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,IMP] [PMID 19029250]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10982835]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 21335519]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 12008673]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9624054]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA] [PMID 10982835]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IMP] [PMID 17242201]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 22751017]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 12507428]; GO_process: GO:0042255 - ribosome assembly [Evidence IMP] [PMID 22770215]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_636	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004452 - isopentenyl-diphosphate delta-isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004452 - isopentenyl-diphosphate delta-isomerase activity [Evidence IDA] [PMID 2681212]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0050992 - dimethylallyl diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0045337 - farnesyl diphosphate biosynthetic process [Evidence IDA] [PMID 7858969]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_639	Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15282802]; GO_component: GO:0008622 - epsilon DNA polymerase complex [Evidence IDA] [PMID 12571237]; GO_component: GO:0008622 - epsilon DNA polymerase complex [Evidence IDA] [PMID 14673157]; GO_component: GO:0008622 - epsilon DNA polymerase complex [Evidence IDA] [PMID 2406268]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 12882968]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 16369485]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 14622139]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 16916794]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 14622139]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IDA] [PMID 12882968]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IDA] [PMID 14622139]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IDA] [PMID 16369485]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA,IMP] [PMID 19776424]; GO_process: GO:0070868 - heterochromatin organization involved in chromatin silencing [Evidence IC] [PMID 14673157]; GO_process: GO:0045005 - maintenance of fidelity involved in DNA-dependent DNA replication [Evidence IMP] [PMID 18245343]; GO_process: GO:0045005 - maintenance of fidelity involved in DNA-dependent DNA replication [Evidence IMP] [PMID 19463834]
AWJ20_640	Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8183917]; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IPI] [PMID 8232542]; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8583924]; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8756702]; GO_function: GO:0004663 - Rab geranylgeranyltransferase activity [Evidence IEA]; GO_function: GO:0004663 - Rab geranylgeranyltransferase activity [Evidence IDA] [PMID 8756702]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 3312234]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8232541]; GO_process: GO:0018344 - protein geranylgeranylation [Evidence IDA] [PMID 8756702]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 1903184]
AWJ20_641	73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 8804308]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8816487]; GO_process: GO:0061412 - positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [Evidence IMP] [PMID 10549298]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_642	73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 8804308]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8816487]; GO_process: GO:0061412 - positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [Evidence IMP] [PMID 10549298]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_643	Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IPI] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 2279699]; GO_component: GO:0000784 - nuclear chromosome, telomeric region [Evidence IDA] [PMID 19005221]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 2279699]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10075735]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9159120]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IMP] [PMID 17895243]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 2279699]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 16980387]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0006343 - establishment of chromatin silencing [Evidence IMP] [PMID 12750362]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 19005221]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 2044962]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 9990508]
AWJ20_647	Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 16267052]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24390141]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0071618 - lysophosphatidylethanolamine acyltransferase activity [Evidence IDA] [PMID 20016004]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 12682047]; GO_process: GO:0007114 - cell budding [Evidence IGI,IMP] [PMID 19150427]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 10515935]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI,IMP] [PMID 16267052]
AWJ20_648	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 22343726]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 22343726]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_649	Ribosome-associated chaperone; functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20368619]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IMP] [PMID 20368619]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 16413483]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 17242366]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence NAS] [PMID 9707440]; GO_process: GO:0006457 - protein folding [Evidence NAS] [PMID 9707440]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 20368619]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 15456889]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP] [PMID 20368619]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 16607023]
AWJ20_650	Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 10551827]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 10409709]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0017110 - nucleoside-diphosphatase activity [Evidence IDA] [PMID 10409709]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IDA] [PMID 10409709]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 10409709]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
AWJ20_651	Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9115231]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14988731]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 14988731]; GO_process: GO:0030001 - metal ion transport [Evidence IMP] [PMID 9115231]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 14988731]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 9988727]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16456538]
AWJ20_652	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_653	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0033754 - indoleamine 2,3-dioxygenase activity [Evidence IEA]; GO_function: GO:0033754 - indoleamine 2,3-dioxygenase activity [Evidence IDA] [PMID 21170645]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IGI] [PMID 12062417]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0019441 - tryptophan catabolic process to kynurenine [Evidence IC] [PMID 21170645]
AWJ20_657	Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9603875]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0004471 - malate dehydrogenase (decarboxylating) (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004470 - malic enzyme activity [Evidence IEA]; GO_function: GO:0004470 - malic enzyme activity [Evidence IDA,ISS] [PMID 9603875]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008948 - oxaloacetate decarboxylase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IMP] [PMID 9603875]; GO_process: GO:0006108 - malate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 9603875]
AWJ20_658	Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9603875]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0004471 - malate dehydrogenase (decarboxylating) (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004470 - malic enzyme activity [Evidence IEA]; GO_function: GO:0004470 - malic enzyme activity [Evidence IDA,ISS] [PMID 9603875]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008948 - oxaloacetate decarboxylase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IMP] [PMID 9603875]; GO_process: GO:0006108 - malate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 9603875]
AWJ20_659	Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9603875]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0004471 - malate dehydrogenase (decarboxylating) (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004470 - malic enzyme activity [Evidence IEA]; GO_function: GO:0004470 - malic enzyme activity [Evidence IDA,ISS] [PMID 9603875]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008948 - oxaloacetate decarboxylase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IMP] [PMID 9603875]; GO_process: GO:0006108 - malate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 9603875]
AWJ20_660	Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0070209 - ASTRA complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]
AWJ20_661	TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo; homologous to largest and second largest subunits of human and Drosophila TFIIA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005672 - transcription factor TFIIA complex [Evidence IEA]; GO_component: GO:0005672 - transcription factor TFIIA complex [Evidence IDA] [PMID 7862117]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA] [PMID 7604282]; GO_function: GO:0001129 - TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [Evidence IDA,IGI] [PMID 10567590]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA,IGI] [PMID 10567590]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 7862117]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_664	High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress; GO_component: GO:0033573 - high affinity iron permease complex [Evidence IDA] [PMID 16522632]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10748025]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16700543]; GO_function: GO:0005381 - iron ion transmembrane transporter activity [Evidence IDA] [PMID 16700543]; GO_function: GO:0005381 - iron ion transmembrane transporter activity [Evidence IDA] [PMID 8599111]; GO_process: GO:1901684 - arsenate ion transmembrane transport [Evidence IGI] [PMID 23295455]; GO_process: GO:0006827 - high-affinity iron ion transport [Evidence IMP] [PMID 16700543]; GO_process: GO:0006827 - high-affinity iron ion transport [Evidence IGI,IMP] [PMID 8599111]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0033215 - iron assimilation by reduction and transport [Evidence IMP] [PMID 16700543]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_667	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001103 - RNA polymerase II repressing transcription factor binding [Evidence IPI] [PMID 11470794]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_670	Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9224719]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IMP] [PMID 10899131]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,TAS] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 10899131]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA,TAS] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_672	GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19380492]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 9171383]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 19380492]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0051457 - maintenance of protein location in nucleus [Evidence IPI] [PMID 19380492]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI] [PMID 9106207]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI,IMP] [PMID 9171427]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_674	Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20065092]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20065092]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000301 - retrograde transport, vesicle recycling within Golgi [Evidence IMP] [PMID 11703943]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_675	Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016742 - hydroxymethyl-, formyl- and related transferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0004644 - phosphoribosylglycinamide formyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004644 - phosphoribosylglycinamide formyltransferase activity [Evidence IGI,IMP] [PMID 4581491]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 4581491]; GO_process: GO:0046084 - adenine biosynthetic process [Evidence IMP] [PMID 17247984]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 4581491]
AWJ20_676	Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18504300]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9207060]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9312134]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
AWJ20_677	Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD); GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 24750273]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_678	Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11447111]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11447111]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 18559667]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 11447111]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IGI,IMP] [PMID 18559667]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11447111]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_679	Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes; GO_component: GO:0000815 - ESCRT III complex [Evidence IDA] [PMID 12194857]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12194857]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 15086794]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IGI] [PMID 23444383]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 12953057]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
AWJ20_680	Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004655 - porphobilinogen synthase activity [Evidence IEA,IEA]; GO_function: GO:0004655 - porphobilinogen synthase activity [Evidence IDA] [PMID 2204246]; GO_function: GO:0004655 - porphobilinogen synthase activity [Evidence IMP] [PMID 2445751]; GO_function: GO:0004655 - porphobilinogen synthase activity [Evidence IMP] [PMID 323256]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 14559249]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 323256]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]; GO_process: GO:0033014 - tetrapyrrole biosynthetic process [Evidence IEA]
AWJ20_681	Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9874242]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IDA,IMP,ISS] [PMID 9874242]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence IDA] [PMID 9874242]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
AWJ20_683	Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated; GO_component: GO:0030874 - nucleolar chromatin [Evidence IPI] [PMID 20814424]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051731 - polynucleotide 5'-hydroxyl-kinase activity [Evidence IDA] [PMID 20814424]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 23175604]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0006363 - termination of RNA polymerase I transcription [Evidence IMP] [PMID 20814424]
AWJ20_685	Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12024012]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11399075]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 12024012]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9755175]; GO_function: GO:0001103 - RNA polymerase II repressing transcription factor binding [Evidence IPI] [PMID 11399075]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IPI] [PMID 11399075]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IPI] [PMID 9755175]; GO_process: GO:0016458 - gene silencing [Evidence IMP] [PMID 15016375]; GO_process: GO:1900460 - negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15466424]; GO_process: GO:1900460 - negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 9811878]; GO_process: GO:1900462 - negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12024012]; GO_process: GO:1900462 - negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 9811878]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17594096]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_686	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 3004948]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IDA] [PMID 3004948]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006089 - lactate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_687	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_688	Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9874242]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003878 - ATP citrate synthase activity [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IEA,IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IDA,IMP,ISS] [PMID 9874242]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence IDA] [PMID 9874242]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
AWJ20_691	AAA ATPase; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing, in macroautophagy, PMN, RAD, ribophagy, homotypic ER membrane fusion, disassembly of Met30p from SCF complex, functional ortholog of human p97/VCP; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11598205]; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11733065]; GO_component: GO:0036266 - Cdc48p-Npl4p-Vms1p AAA ATPase complex [Evidence IDA] [PMID 21070972]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15910746]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23479637]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 15910746]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 21070972]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9436996]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 7492595]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008599 - protein phosphatase type 1 regulator activity [Evidence IMP] [PMID 23418575]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 11733065]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11740563]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11813000]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11739805]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11756557]; GO_process: GO:1990171 - SCF complex disassembly in response to cadmium stress [Evidence IMP] [PMID 23000173]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18812321]; GO_process: GO:0016320 - endoplasmic reticulum membrane fusion [Evidence IMP] [PMID 7553849]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20855502]; GO_process: GO:0072671 - mitochondria-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21070972]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 14636562]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22718752]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 20855502]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11598205]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11733065]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20206597]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11740563]; GO_process: GO:0034517 - ribophagy [Evidence IMP] [PMID 20508643]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23479637]; GO_process: GO:0031134 - sister chromatid biorientation [Evidence IMP] [PMID 20483956]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_692	AAA ATPase; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing, in macroautophagy, PMN, RAD, ribophagy, homotypic ER membrane fusion, disassembly of Met30p from SCF complex, functional ortholog of human p97/VCP; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11598205]; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11733065]; GO_component: GO:0036266 - Cdc48p-Npl4p-Vms1p AAA ATPase complex [Evidence IDA] [PMID 21070972]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15910746]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23479637]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 15910746]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 21070972]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9436996]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 7492595]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008599 - protein phosphatase type 1 regulator activity [Evidence IMP] [PMID 23418575]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 11733065]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11740563]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11813000]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11739805]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11756557]; GO_process: GO:1990171 - SCF complex disassembly in response to cadmium stress [Evidence IMP] [PMID 23000173]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18812321]; GO_process: GO:0016320 - endoplasmic reticulum membrane fusion [Evidence IMP] [PMID 7553849]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20855502]; GO_process: GO:0072671 - mitochondria-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21070972]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 14636562]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22718752]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 20855502]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11598205]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11733065]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20206597]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11740563]; GO_process: GO:0034517 - ribophagy [Evidence IMP] [PMID 20508643]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23479637]; GO_process: GO:0031134 - sister chromatid biorientation [Evidence IMP] [PMID 20483956]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_693	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_694	Subunit of the SF3a splicing factor complex; required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 8065365]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 8969185]
AWJ20_695	TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 12242279]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 7995524]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IDA] [PMID 14749386]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IC] [PMID 7995524]; GO_function: GO:0072542 - protein phosphatase activator activity [Evidence IDA] [PMID 11904169]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 7995524]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IGI] [PMID 11003641]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 11904169]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001111 - promoter clearance from RNA polymerase II promoter [Evidence IC] [PMID 7995524]; GO_process: GO:0080163 - regulation of protein serine/threonine phosphatase activity [Evidence IDA] [PMID 11904169]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 18362165]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 18362165]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IGI,IMP] [PMID 15572698]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IGI,IMP] [PMID 16081422]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IGI] [PMID 16147988]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IMP] [PMID 18362165]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IGI] [PMID 7724527]
AWJ20_698	Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IDA] [PMID 11805111]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence ISS] [PMID 9164465]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IDA] [PMID 11805111]
AWJ20_699	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; GO_component: GO:0031415 - NatA complex [Evidence IDA] [PMID 14517307]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 14517307]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IDA,IMP] [PMID 2551674]; GO_process: GO:0006474 - N-terminal protein amino acid acetylation [Evidence IDA,IMP] [PMID 2551674]
AWJ20_700	Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence ISM] [PMID 15466869]; GO_function: GO:0043723 - 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity [Evidence IMP] [PMID 4555411]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008835 - diaminohydroxyphosphoribosylaminopyrimidine deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 15466869]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence ISS] [PMID 8710514]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 4555411]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 15466869]
AWJ20_701	Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISM] [PMID 15466869]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 15466869]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 15466869]
AWJ20_702	Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704371]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 10704371]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 15107621]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 15107621]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007089 - traversing start control point of mitotic cell cycle [Evidence IMP] [PMID 11160833]
AWJ20_704	ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11222764]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 11222764]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 16772403]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11222764]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11222764]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11222764]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_705	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071028 - nuclear mRNA surveillance [Evidence IGI,IMP] [PMID 11030620]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 18591258]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12769863]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 10508172]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_706	hypothetical protein; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 10093218]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_707	Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 8798783]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0000064 - L-ornithine transmembrane transporter activity [Evidence IDA] [PMID 9237680]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IMP] [PMID 8798783]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000066 - mitochondrial ornithine transport [Evidence IDA] [PMID 9237680]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_708	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_709	ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000838 - Hrd1p ubiquitin ligase ERAD-M complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IPI] [PMID 16619026]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0034099 - luminal surveillance complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 11390656]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 12105183]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 24292014]
AWJ20_710	Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008251 - tRNA-specific adenosine deaminase activity [Evidence IDA] [PMID 10550050]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 10550050]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_711	Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12048214]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 17420293]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 12048214]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 12048214]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 12554655]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 12048214]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 12554655]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IGI,IMP,IPI] [PMID 12554655]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12554655]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_712	tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008193 - tRNA guanylyltransferase activity [Evidence IEA]; GO_function: GO:0008193 - tRNA guanylyltransferase activity [Evidence IDA] [PMID 14633974]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 14633974]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_713	Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control; GO_component: GO:0000502 - proteasome complex [Evidence IEA,IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0042176 - regulation of protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
AWJ20_714	JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p methyltransferase; negatively regulated by H3K14 acetylation; protein levels regulated by Not4p polyubiquitin-mediated degradation; regulates spore differentiation timing by extending period of active transcription in opposition to programmed global transcriptional quiescence; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0032453 - histone demethylase activity (H3-K4 specific) [Evidence IDA,IMP] [PMID 17310254]; GO_function: GO:0032453 - histone demethylase activity (H3-K4 specific) [Evidence IMP] [PMID 17369256]; GO_function: GO:0034649 - histone demethylase activity (H3-monomethyl-K4 specific) [Evidence IMP] [PMID 19346402]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0034720 - histone H3-K4 demethylation [Evidence IMP] [PMID 23123093]; GO_process: GO:0016577 - histone demethylation [Evidence IDA,IMP] [PMID 17310254]; GO_process: GO:0016577 - histone demethylation [Evidence IMP] [PMID 17369256]; GO_process: GO:0097549 - negative regulation of transcription by chromatin organization [Evidence IMP] [PMID 23123093]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_715	Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR); GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence IEA,IEA]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence IDA,ISS] [PMID 10600168]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006555 - methionine metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
AWJ20_716	hypothetical protein; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_718	ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 2661018]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0034099 - luminal surveillance complex [Evidence IDA] [PMID 16873065]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 1325440]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 12808051]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 23704572]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11381090]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 7568189]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 10069807]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 10367885]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 7568189]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006986 - response to unfolded protein [Evidence IMP] [PMID 12808051]
AWJ20_719	Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 12473689]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IPI] [PMID 10704439]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IDA,IPI] [PMID 11726501]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 12473689]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051312 - chromosome decondensation [Evidence IMP] [PMID 17151360]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IGI] [PMID 16651657]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI,IMP] [PMID 10704439]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IPI] [PMID 9461437]
AWJ20_720	Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IPI] [PMID 9671501]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0005092 - GDP-dissociation inhibitor activity [Evidence IDA,IMP] [PMID 20485439]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence ISS] [PMID 11092890]; GO_function: GO:0005096 - GTPase activator activity [Evidence IPI] [PMID 9395514]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 22683627]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9395514]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 12008673]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 8486705]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 9395514]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 15145951]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA] [PMID 22683627]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IPI] [PMID 22851688]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0042256 - mature ribosome assembly [Evidence IMP] [PMID 11331597]; GO_process: GO:0045947 - negative regulation of translational initiation [Evidence IGI,IMP] [PMID 20485439]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP,IPI] [PMID 11331597]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA,IMP] [PMID 22851688]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
AWJ20_723	Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein; GO_component: GO:0005686 - U2 snRNP [Evidence IDA,IPI] [PMID 9799242]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 9799242]
AWJ20_724	Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16850348]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004417 - hydroxyethylthiazole kinase activity [Evidence IEA,IEA]; GO_function: GO:0004417 - hydroxyethylthiazole kinase activity [Evidence IMP] [PMID 7982968]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004789 - thiamine-phosphate diphosphorylase activity [Evidence IEA,IEA]; GO_function: GO:0004789 - thiamine-phosphate diphosphorylase activity [Evidence IMP] [PMID 7982968]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IMP] [PMID 7982968]; GO_process: GO:0009229 - thiamine diphosphate biosynthetic process [Evidence IEA]
AWJ20_725	Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14657274]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence ISS] [PMID 14534547]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IDA] [PMID 18946088]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP,ISS] [PMID 14657274]; GO_process: GO:0006915 - apoptotic process [Evidence IMP,ISS] [PMID 16470384]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16608876]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP,IPI] [PMID 16470384]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 18946088]; GO_process: GO:0030163 - protein catabolic process [Evidence IMP] [PMID 18946088]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_727	Covalently-bound cell wall hypothetical protein; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11935221]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_729	Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 196563]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004612 - phosphoenolpyruvate carboxykinase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0004612 - phosphoenolpyruvate carboxykinase (ATP) activity [Evidence IDA] [PMID 16330239]; GO_function: GO:0004612 - phosphoenolpyruvate carboxykinase (ATP) activity [Evidence IMP] [PMID 2689220]; GO_function: GO:0004611 - phosphoenolpyruvate carboxykinase activity [Evidence IEA]; GO_function: GO:0017076 - purine nucleotide binding [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA,IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEP] [PMID 2689220]
AWJ20_730	Protein with a potential role in cell survival pathways; required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 16034825]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
AWJ20_734	U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9418882]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 9418882]
AWJ20_735	Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004418 - hydroxymethylbilane synthase activity [Evidence IEA,IEA]; GO_function: GO:0004418 - hydroxymethylbilane synthase activity [Evidence IMP] [PMID 1508149]; GO_function: GO:0004418 - hydroxymethylbilane synthase activity [Evidence IMP] [PMID 323256]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 14559249]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 323256]; GO_process: GO:0018160 - peptidyl-pyrromethane cofactor linkage [Evidence IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]; GO_process: GO:0033014 - tetrapyrrole biosynthetic process [Evidence IEA]
AWJ20_738	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; BMH2 has a paralog, BMH1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12167636]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 12167636]; GO_function: GO:0050815 - phosphoserine binding [Evidence IMP] [PMID 9822578]; GO_function: GO:0019904 - protein domain specific binding [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 14704161]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI] [PMID 19934224]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IGI] [PMID 9215628]; GO_process: GO:0030437 - ascospore formation [Evidence IGI] [PMID 9215628]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IGI] [PMID 17559233]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IGI] [PMID 9215628]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IMP] [PMID 22785534]; GO_process: GO:0051436 - negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [Evidence IPI] [PMID 17030612]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IGI] [PMID 19934224]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 9215628]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IGI] [PMID 9215628]
AWJ20_740	Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7009582]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004735 - pyrroline-5-carboxylate reductase activity [Evidence IEA,IEA]; GO_function: GO:0004735 - pyrroline-5-carboxylate reductase activity [Evidence ISS] [PMID 1508147]; GO_function: GO:0004735 - pyrroline-5-carboxylate reductase activity [Evidence IGI] [PMID 2824433]; GO_process: GO:0055129 - L-proline biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IMP,ISS] [PMID 1508147]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IMP] [PMID 2824433]
AWJ20_741	Peroxisomal membrane signal receptor for peroxisomal matrix proteins; receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins; required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8858166]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 16849337]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IPI] [PMID 8858166]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 15632140]; GO_function: GO:0005052 - peroxisome matrix targeting signal-1 binding [Evidence IMP] [PMID 11154700]; GO_function: GO:0005052 - peroxisome matrix targeting signal-1 binding [Evidence IDA] [PMID 7980572]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 15798189]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 12595255]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IMP,IPI] [PMID 16849337]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_742	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0033613 - activating transcription factor binding [Evidence IDA] [PMID 9660972]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IMP] [PMID 19805365]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IPI] [PMID 21415355]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 16962561]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8187178]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IMP] [PMID 16263706]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_743	Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2; GO_component: GO:0000974 - Prp19 complex [Evidence IPI] [PMID 12088152]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 19435883]; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 19435883]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IDA] [PMID 19435883]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 19435883]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0036002 - pre-mRNA binding [Evidence IDA] [PMID 19435883]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IC] [PMID 19435883]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0045292 - mRNA cis splicing, via spliceosome [Evidence IMP] [PMID 19435883]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 12088152]; GO_process: GO:0000387 - spliceosomal snRNP assembly [Evidence IDA] [PMID 19435883]
AWJ20_744	Alpha arrestin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 20739461]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 20739461]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 20956561]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IPI] [PMID 18976803]; GO_process: GO:2000397 - positive regulation of ubiquitin-dependent endocytosis [Evidence IMP] [PMID 20956561]; GO_process: GO:0032386 - regulation of intracellular transport [Evidence IMP] [PMID 20739461]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence ISA] [PMID 18976803]
AWJ20_748	Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004038 - allantoinase activity [Evidence IEA,IEA]; GO_function: GO:0004038 - allantoinase activity [Evidence IMP] [PMID 1803816]; GO_function: GO:0004038 - allantoinase activity [Evidence IMP] [PMID 4604238]; GO_function: GO:0050897 - cobalt ion binding [Evidence IEA]; GO_function: GO:0016888 - endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0009442 - allantoin assimilation pathway [Evidence IMP] [PMID 1803816]; GO_process: GO:0009442 - allantoin assimilation pathway [Evidence IMP] [PMID 4604238]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IEA,IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IEA]
AWJ20_750	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0000276 - mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IBA,IEA]; GO_component: GO:0000274 - mitochondrial proton-transporting ATP synthase, stator stalk [Evidence IDA] [PMID 18722382]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045263 - proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IMP] [PMID 8068646]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP] [PMID 8068646]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0035786 - protein complex oligomerization [Evidence IMP] [PMID 18293929]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_751	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
AWJ20_753	Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 18806213]; GO_process: GO:0009967 - positive regulation of signal transduction [Evidence IMP] [PMID 18806213]
AWJ20_754	Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IPI] [PMID 15942929]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence TAS] [PMID 9476892]; GO_component: GO:0000346 - transcription export complex [Evidence IPI] [PMID 11979277]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IGI,ISA] [PMID 11156602]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 15942929]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IDA,IMP,IPI] [PMID 11675790]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IDA,IMP] [PMID 11696331]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 11156602]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 17960421]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_755	Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IPI] [PMID 15942929]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence TAS] [PMID 9476892]; GO_component: GO:0000346 - transcription export complex [Evidence IPI] [PMID 11979277]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IGI,ISA] [PMID 11156602]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 15942929]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IDA,IMP,IPI] [PMID 11675790]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IDA,IMP] [PMID 11696331]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 11156602]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 17960421]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_757	Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_758	Subunit (145 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10817999]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 11940675]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8662725]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_760	Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 23613772]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23613772]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004362 - glutathione-disulfide reductase activity [Evidence IEA,IEA]; GO_function: GO:0004362 - glutathione-disulfide reductase activity [Evidence IDA] [PMID 19049979]; GO_function: GO:0004362 - glutathione-disulfide reductase activity [Evidence IDA] [PMID 7737505]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016668 - oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Evidence IEA]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 8951820]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0010731 - protein glutathionylation [Evidence IGI] [PMID 20074363]
AWJ20_761	Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0030619 - U1 snRNA binding [Evidence IPI] [PMID 1387202]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]
AWJ20_765	3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence ISM] [PMID 1551874]; GO_function: GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase activity [Evidence IDA] [PMID 1551874]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004300 - enoyl-CoA hydratase activity [Evidence IDA] [PMID 1551874]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 10497229]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 1551874]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_766	2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 11092862]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046421 - methylisocitrate lyase activity [Evidence IEA]; GO_function: GO:0046421 - methylisocitrate lyase activity [Evidence IDA] [PMID 11092862]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019629 - propionate catabolic process, 2-methylcitrate cycle [Evidence IDA] [PMID 11092862]
AWJ20_767	Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_768	Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15306853]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15306853]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9162072]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 11389896]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9162072]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP,IPI] [PMID 17882259]
AWJ20_769	6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 1657152]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IEA,IEA]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IDA] [PMID 1322693]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IMP] [PMID 1657152]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence IMP] [PMID 1657152]; GO_process: GO:0006000 - fructose metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_771	similar to ribonuclease H
AWJ20_772	Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
AWJ20_773	Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
AWJ20_775	High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_776	Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 12682021]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IMP] [PMID 18332121]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000455 - enzyme-directed rRNA pseudouridine synthesis [Evidence IMP] [PMID 18332121]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 12682021]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IMP] [PMID 14561887]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IMP] [PMID 14561887]
AWJ20_777	Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005459 - UDP-galactose transmembrane transporter activity [Evidence ISS] [PMID 11284010]; GO_process: GO:0015785 - UDP-galactose transport [Evidence IMP] [PMID 11284009]; GO_process: GO:0015786 - UDP-glucose transport [Evidence IGI,IMP] [PMID 18693752]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_778	Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 15973433]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10419517]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0061133 - endopeptidase activator activity [Evidence IMP] [PMID 8808631]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
AWJ20_779	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_780	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IMP] [PMID 9524130]; GO_component: GO:0071021 - U2-type post-spliceosomal complex [Evidence IMP] [PMID 12212850]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 9582286]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IDA] [PMID 12212850]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 9524130]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IDA] [PMID 12212850]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 22408182]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000390 - spliceosomal complex disassembly [Evidence IMP] [PMID 9524130]
AWJ20_781	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004807 - triose-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004807 - triose-phosphate isomerase activity [Evidence IDA] [PMID 236471]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 11329176]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]
AWJ20_782	Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments; GO_component: GO:0042729 - DASH complex [Evidence IEA]; GO_component: GO:0042729 - DASH complex [Evidence IDA] [PMID 15640796]; GO_component: GO:0042729 - DASH complex [Evidence IDA] [PMID 15664196]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0072686 - mitotic spindle [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 15664196]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 16777964]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 17620411]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 20479465]; GO_process: GO:0008608 - attachment of spindle microtubules to kinetochore [Evidence IEA]; GO_process: GO:0008608 - attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 17620411]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0051987 - positive regulation of attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 20479465]; GO_process: GO:0051987 - positive regulation of attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 20479468]; GO_process: GO:0031116 - positive regulation of microtubule polymerization [Evidence IDA] [PMID 15664196]
AWJ20_783	AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 12872006]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0018064 - protein-histidine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0018064 - protein-histidine N-methyltransferase activity [Evidence IMP] [PMID 20864530]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0042038 - peptidyl-histidine methylation, to form tele-methylhistidine [Evidence IMP] [PMID 20864530]
AWJ20_784	Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_786	Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11536335]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0015293 - symporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11536335]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 11536335]
AWJ20_788	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 9920864]; GO_process: GO:1902047 - polyamine transmembrane transport [Evidence IMP] [PMID 24136413]; GO_process: GO:0015847 - putrescine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_789	Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 10377407]; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 9210376]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IPI] [PMID 14554195]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 10377407]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 14554195]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 14554195]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 11248049]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IMP] [PMID 7929582]; GO_process: GO:0030833 - regulation of actin filament polymerization [Evidence IEA]
AWJ20_790	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence ISA] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence ISA] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence ISA] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_791	Putative serine/threonine protein phosphatase; putative phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence ISS] [PMID 7678255]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IMP] [PMID 7678255]; GO_process: GO:0006470 - protein dephosphorylation [Evidence ISS] [PMID 7678255]
AWJ20_792	one of three or four genes related to conserved fungal hypothetical proteins (NCU00659.1, MG03673.4, AN4711.2)
AWJ20_793	Aminophospholipid translocase (flippase); localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase; DNF2 has a paralog, DNF1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12221123]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12631737]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 12631737]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI,IMP] [PMID 12631737]; GO_process: GO:0007163 - establishment or maintenance of cell polarity [Evidence IGI] [PMID 15461661]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI,IMP] [PMID 12631737]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_794	Aminophospholipid translocase (flippase); localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase; DNF1 has a paralog, DNF2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12221123]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12631737]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence ISS] [PMID 9224683]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI] [PMID 12631737]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI,IMP] [PMID 12631737]; GO_process: GO:0007163 - establishment or maintenance of cell polarity [Evidence IGI] [PMID 15461661]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI] [PMID 12631737]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_796	Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004103 - choline kinase activity [Evidence IDA,IGI,ISS] [PMID 10329685]; GO_function: GO:0004305 - ethanolamine kinase activity [Evidence IEA]; GO_function: GO:0004305 - ethanolamine kinase activity [Evidence IDA,IGI,IMP,ISS] [PMID 10329685]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IGI,IMP] [PMID 10329685]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IGI,IMP] [PMID 10329685]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_797	Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20368619]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 17242366]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 17242366]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IMP] [PMID 20368619]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 17242366]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 20368619]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17242366]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP] [PMID 20368619]
AWJ20_798	Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9872948]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9872948]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9872948]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9872948]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0052381 - tRNA dimethylallyltransferase activity [Evidence IEA]; GO_function: GO:0052381 - tRNA dimethylallyltransferase activity [Evidence IDA] [PMID 18852462]; GO_function: GO:0052381 - tRNA dimethylallyltransferase activity [Evidence IDA] [PMID 3031456]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 18852462]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 3031456]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_800	Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 11698381]; GO_process: GO:0016485 - protein processing [Evidence IDA,IGI,IMP] [PMID 11698381]; GO_process: GO:0006508 - proteolysis [Evidence IMP] [PMID 11698381]; GO_process: GO:0009268 - response to pH [Evidence IMP] [PMID 11698381]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 11698381]
AWJ20_801	Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport; GO_component: GO:0030121 - AP-1 adaptor complex [Evidence IPI,ISS] [PMID 10564262]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IPI,ISS] [PMID 10564262]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 17003107]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IPI,ISS] [PMID 10564262]
AWJ20_802	Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog, SFB2, that arose from the whole genome duplication; GO_component: GO:0030127 - COPII vesicle coat [Evidence IEA]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IMP] [PMID 12941277]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA] [PMID 12941277]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA] [PMID 14627716]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA] [PMID 15665868]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_803	tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF); GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15944150]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IEA]; GO_function: GO:0004808 - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0004808 - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity [Evidence IMP] [PMID 15509579]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0070903 - mitochondrial tRNA thio-modification [Evidence IMP] [PMID 15509579]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_806	Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9696750]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9733747]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence IDA,ISS] [PMID 9696750]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence IDA,ISS] [PMID 9733747]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 12032156]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 16436509]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IMP] [PMID 9696750]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IMP] [PMID 9733747]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_807	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_809	Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0005087 - Ran guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 19549784]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 7622450]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0051292 - nuclear pore complex assembly [Evidence IMP] [PMID 17182855]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IGI,IMP] [PMID 19141610]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 19141610]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 23131016]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 16929305]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0060188 - regulation of protein desumoylation [Evidence IMP] [PMID 17403926]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_810	Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1736091]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0008409 - 5'-3' exonuclease activity [Evidence IDA,IMP] [PMID 15590324]; GO_function: GO:0003684 - damaged DNA binding [Evidence IMP] [PMID 7035927]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 1736091]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence TAS] [PMID 12509272]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI,IMP] [PMID 22912599]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_811	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0015124 - allantoate transmembrane transporter activity [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IMP] [PMID 16429164]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IGI,IMP] [PMID 17693598]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015719 - allantoate transport [Evidence IMP] [PMID 3275614]; GO_process: GO:0042938 - dipeptide transport [Evidence IMP] [PMID 16429164]; GO_process: GO:0042938 - dipeptide transport [Evidence IGI,IMP] [PMID 17693598]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IMP] [PMID 16429164]
AWJ20_813	Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_815	Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16874307]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 16874307]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 8756348]; GO_process: GO:0009968 - negative regulation of signal transduction [Evidence IEA]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IGI,IMP] [PMID 19684113]; GO_process: GO:0009966 - regulation of signal transduction [Evidence IEA]
AWJ20_816	Metalloprotease; involved in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family; homolog Axl1p is also involved in processing of pro-a-factor; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 15944156]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 19750477]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence ISS] [PMID 7569998]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0007323 - peptide pheromone maturation [Evidence IGI] [PMID 7569998]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]
AWJ20_817	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_818	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_819	E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; deubiquitinated by Ubp2p; autoubiquitinates and ubiquitinates Sec23p and Sna3p; required for efficient Golgi-to-ER trafficking in COPI mutants; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14657247]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 14608372]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14657247]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15078904]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 14657247]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 15078904]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14608372]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0000151 - ubiquitin ligase complex [Evidence IPI] [PMID 9931424]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IDA] [PMID 15078904]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 19252184]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 21685393]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 9108033]; GO_process: GO:0034644 - cellular response to UV [Evidence IMP] [PMID 10490634]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IMP] [PMID 12399376]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP,IPI] [PMID 17182849]; GO_process: GO:0007005 - mitochondrion organization [Evidence IGI,IMP] [PMID 10366593]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 12654912]; GO_process: GO:0045723 - positive regulation of fatty acid biosynthetic process [Evidence IMP] [PMID 11007476]; GO_process: GO:0048260 - positive regulation of receptor-mediated endocytosis [Evidence IMP] [PMID 11179425]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11007476]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 15713680]; GO_process: GO:0051865 - protein autoubiquitination [Evidence IGI] [PMID 24069405]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IGI,IMP] [PMID 14761940]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA,IGI,IMP] [PMID 19176477]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA,IMP] [PMID 21685393]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA,IMP] [PMID 9108033]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9614172]; GO_process: GO:0032956 - regulation of actin cytoskeleton organization [Evidence IGI] [PMID 15855235]; GO_process: GO:0010794 - regulation of dolichol biosynthetic process [Evidence IGI,IMP] [PMID 18771750]; GO_process: GO:0032443 - regulation of ergosterol biosynthetic process [Evidence IGI,IMP] [PMID 18771750]; GO_process: GO:0031384 - regulation of initiation of mating projection growth [Evidence IMP] [PMID 21685393]; GO_process: GO:0010793 - regulation of mRNA export from nucleus [Evidence IMP] [PMID 14608372]; GO_process: GO:0010793 - regulation of mRNA export from nucleus [Evidence IPI] [PMID 15713680]; GO_process: GO:0010796 - regulation of multivesicular body size [Evidence IMP] [PMID 17182850]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IGI] [PMID 15247235]; GO_process: GO:0019220 - regulation of phosphate metabolic process [Evidence IGI] [PMID 18165238]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP,IPI] [PMID 12867034]; GO_process: GO:2000232 - regulation of rRNA processing [Evidence IMP] [PMID 14608372]; GO_process: GO:2000203 - regulation of ribosomal large subunit export from nucleus [Evidence IMP] [PMID 14608372]; GO_process: GO:2000238 - regulation of tRNA export from nucleus [Evidence IMP] [PMID 14608372]; GO_process: GO:2000235 - regulation of tRNA processing [Evidence IMP] [PMID 14608372]; GO_process: GO:0010795 - regulation of ubiquinone biosynthetic process [Evidence IGI,IMP] [PMID 18771750]; GO_process: GO:0042493 - response to drug [Evidence IMP,IPI] [PMID 12163175]; GO_process: GO:0034517 - ribophagy [Evidence IGI] [PMID 18670191]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence IMP] [PMID 17344478]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 17344478]
AWJ20_820	Permease of basic amino acids in the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15572352]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015174 - basic amino acid transmembrane transporter activity [Evidence IDA,IMP] [PMID 15572352]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015802 - basic amino acid transport [Evidence IMP] [PMID 15572352]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_821	Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 22593576]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 3888995]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:1990077 - primosome complex [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003896 - DNA primase activity [Evidence IEA]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 2644256]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 3061469]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 3888995]; GO_function: GO:0003896 - DNA primase activity [Evidence IGI,IMP] [PMID 8436268]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 20404922]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 2023935]; GO_process: GO:0006270 - DNA replication initiation [Evidence IC] [PMID 3888995]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IEA,IEA]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IDA] [PMID 2644256]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 3888995]
AWJ20_823	Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12937277]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12937277]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 8131744]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 17005296]; GO_process: GO:0010458 - exit from mitosis [Evidence IGI,ISS] [PMID 1916278]; GO_process: GO:0000281 - mitotic cytokinesis [Evidence IGI] [PMID 12937277]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8131744]; GO_process: GO:0061013 - regulation of mRNA catabolic process [Evidence IMP] [PMID 22196726]
AWJ20_824	RanGTP-binding protein; inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12578832]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP,ISS] [PMID 12578832]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0030695 - GTPase regulator activity [Evidence IDA,IPI] [PMID 12578832]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_825	Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11504737]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 21586585]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 11504737]; GO_process: GO:0036003 - positive regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 16176797]; GO_process: GO:0036003 - positive regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 16980434]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16176797]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16980434]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_826	GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0031235 - intrinsic component of the cytoplasmic side of the plasma membrane [Evidence IBA]; GO_component: GO:0016020 - membrane [Evidence IMP,IPI] [PMID 1875942]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA,IEA]; GO_function: GO:0005099 - Ras GTPase activator activity [Evidence IMP] [PMID 2178777]; GO_process: GO:0046580 - negative regulation of Ras protein signal transduction [Evidence IMP] [PMID 15339905]; GO_process: GO:0030818 - negative regulation of cAMP biosynthetic process [Evidence IMP] [PMID 2540426]; GO_process: GO:0032320 - positive regulation of Ras GTPase activity [Evidence IMP] [PMID 2178777]; GO_process: GO:0045761 - regulation of adenylate cyclase activity [Evidence IMP] [PMID 1875942]; GO_process: GO:0051056 - regulation of small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_828	Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004514 - nicotinate-nucleotide diphosphorylase (carboxylating) activity [Evidence IEA,IEA]; GO_function: GO:0004514 - nicotinate-nucleotide diphosphorylase (carboxylating) activity [Evidence IMP] [PMID 12062417]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IGI] [PMID 12062417]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA,IEA]
AWJ20_833	Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IMP] [PMID 17173333]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence ISS] [PMID 9341119]; GO_process: GO:0009436 - glyoxylate catabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence ISS] [PMID 9341119]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_835	hypothetical protein; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 20378542]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_836	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence ISS] [PMID 12003496]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IMP] [PMID 14970222]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0002943 - tRNA dihydrouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence ISS] [PMID 12003496]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 14970222]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_837	some similarities with uniprot|P40033 Saccharomyces cerevisiae YER050C
AWJ20_838	ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 12006565]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA,IMP] [PMID 17646390]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 12006565]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042493 - response to drug [Evidence IMP] [PMID 9341149]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17646390]
AWJ20_839	Putative protein with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004066 - asparagine synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006529 - asparagine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_841	Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; GO_component: GO:0030126 - COPI vesicle coat [Evidence IEA]; GO_component: GO:0030126 - COPI vesicle coat [Evidence IMP,ISS] [PMID 8617224]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8617224]; GO_process: GO:0048313 - Golgi inheritance [Evidence IGI] [PMID 18595704]; GO_process: GO:0051645 - Golgi localization [Evidence IGI] [PMID 18595704]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8617224]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
AWJ20_842	Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity [Evidence IEA]; GO_function: GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity [Evidence IGI,IMP] [PMID 2824992]; GO_function: GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity [Evidence IMP] [PMID 6300049]; GO_function: GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0006198 - cAMP catabolic process [Evidence IEA]; GO_process: GO:0019933 - cAMP-mediated signaling [Evidence IMP] [PMID 9880329]
AWJ20_843	Beta 7 subunit of the 20S proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI] [PMID 17911101]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
AWJ20_844	Beta 7 subunit of the 20S proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI] [PMID 17911101]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
AWJ20_847	Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004061 - arylformamidase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004061 - arylformamidase activity [Evidence IDA] [PMID 18205391]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IDA] [PMID 18205391]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA,IEA]; GO_process: GO:0019441 - tryptophan catabolic process to kynurenine [Evidence IEA,IEA]
AWJ20_851	Vacuolar protein involved in vacuolar membrane fusion tethering; plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p; GO_component: GO:0030897 - HOPS complex [Evidence IPI] [PMID 10944212]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11853670]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9111041]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 11062257]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IDA] [PMID 16601699]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0035542 - regulation of SNARE complex assembly [Evidence IDA] [PMID 18385512]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IDA] [PMID 18385512]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA,IMP] [PMID 10944212]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 9111041]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 12730205]
AWJ20_852	Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 19150991]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IC] [PMID 15590835]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_853	Inositol hexakisphosphate and inositol heptakisphosphate kinase; inositol heptakisphosphate (IP7) production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1; inositol hexakisphosphate is also known as IP6; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003993 - acid phosphatase activity [Evidence IEA]; GO_function: GO:0033857 - diphosphoinositol-pentakisphosphate kinase activity [Evidence IEA]; GO_function: GO:0000829 - inositol heptakisphosphate kinase activity [Evidence IDA] [PMID 17412958]; GO_function: GO:0052723 - inositol hexakisphosphate 1-kinase activity [Evidence IEA]; GO_function: GO:0052723 - inositol hexakisphosphate 1-kinase activity [Evidence IDA] [PMID 18981179]; GO_function: GO:0052724 - inositol hexakisphosphate 3-kinase activity [Evidence IEA]; GO_function: GO:0052724 - inositol hexakisphosphate 3-kinase activity [Evidence IDA] [PMID 18981179]; GO_function: GO:0000830 - inositol hexakisphosphate 4-kinase activity [Evidence IDA] [PMID 17412958]; GO_function: GO:0000830 - inositol hexakisphosphate 4-kinase activity [Evidence IDA] [PMID 18981179]; GO_function: GO:0000832 - inositol hexakisphosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0000831 - inositol hexakisphosphate 6-kinase activity [Evidence IDA] [PMID 17412958]; GO_function: GO:0000831 - inositol hexakisphosphate 6-kinase activity [Evidence IDA] [PMID 18981179]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0032958 - inositol phosphate biosynthetic process [Evidence IDA] [PMID 17412958]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_854	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11101685]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IGI] [PMID 15280369]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IMP] [PMID 10212224]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IGI] [PMID 15280369]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 15470112]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009156 - ribonucleoside monophosphate biosynthetic process [Evidence IEA]
AWJ20_855	Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p; GO_component: GO:0031262 - Ndc80 complex [Evidence IPI] [PMID 11179222]; GO_component: GO:0031262 - Ndc80 complex [Evidence IDA] [PMID 11266451]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA,IMP,IPI] [PMID 11179222]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 11511347]; GO_component: GO:0000780 - condensed nuclear chromosome, centromeric region [Evidence IDA,IGI,IPI] [PMID 11266451]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11266451]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 8188751]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 11266451]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA,IEA]
AWJ20_858	Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11545731]; GO_component: GO:0005856 - cytoskeleton [Evidence IDA] [PMID 15910746]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11545731]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0032165 - prospore septin filament array [Evidence IDA] [PMID 24390141]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 10893184]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IDA] [PMID 8207005]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IGI] [PMID 12810699]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IMP] [PMID 21163942]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IMP] [PMID 7874200]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8207005]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 7874200]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IMP] [PMID 21163942]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 7874200]
AWJ20_859	Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11545731]; GO_component: GO:0005856 - cytoskeleton [Evidence IDA] [PMID 15910746]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11545731]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0032165 - prospore septin filament array [Evidence IDA] [PMID 24390141]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 10893184]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IDA] [PMID 8207005]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IGI] [PMID 12810699]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IMP] [PMID 21163942]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IMP] [PMID 7874200]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8207005]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 7874200]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IMP] [PMID 21163942]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 7874200]
AWJ20_860	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_861	Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 6025308]; GO_component: GO:0005835 - fatty acid synthase complex [Evidence IEA]; GO_component: GO:0005835 - fatty acid synthase complex [Evidence IDA] [PMID 65153]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 17803462]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IEA]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Evidence IDA] [PMID 374077]; GO_function: GO:0047451 - 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [Evidence IEA]; GO_function: GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0004313 - [acyl-carrier-protein] S-acetyltransferase activity [Evidence IDA] [PMID 374077]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IEA]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IDA] [PMID 365179]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IDA] [PMID 374077]; GO_function: GO:0016297 - acyl-[acyl-carrier-protein] hydrolase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004318 - enoyl-[acyl-carrier-protein] reductase (NADH) activity [Evidence IEA,IEA]; GO_function: GO:0004319 - enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0004319 - enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [Evidence IDA] [PMID 374077]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IEA]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0004312 - fatty acid synthase activity [Evidence IMP] [PMID 65153]; GO_function: GO:0004321 - fatty-acyl-CoA synthase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016295 - myristoyl-[acyl-carrier-protein] hydrolase activity [Evidence IEA]; GO_function: GO:0004320 - oleoyl-[acyl-carrier-protein] hydrolase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016296 - palmitoyl-[acyl-carrier-protein] hydrolase activity [Evidence IEA]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IMP] [PMID 1100391]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IDA] [PMID 365179]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0042759 - long-chain fatty acid biosynthetic process [Evidence IMP] [PMID 1735446]; GO_process: GO:0042759 - long-chain fatty acid biosynthetic process [Evidence IMP] [PMID 4127627]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_862	Protein involved in microtubule-related processes; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007017 - microtubule-based process [Evidence IMP] [PMID 18064466]
AWJ20_863	Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage; GO_component: GO:0043505 - centromere-specific nucleosome [Evidence IDA] [PMID 22693454]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 21460225]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI] [PMID 19917722]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 16002464]; GO_process: GO:0043935 - sexual sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 20713519]
AWJ20_865	AAA-peroxin; heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA,IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 16911527]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IMP] [PMID 15634331]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 1825027]; GO_function: GO:0042623 - ATPase activity, coupled [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IMP,IPI] [PMID 15634331]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16007078]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16911527]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA,IEA]; GO_process: GO:0016562 - protein import into peroxisome matrix, receptor recycling [Evidence IDA,IGI,IMP] [PMID 16007078]; GO_process: GO:0006625 - protein targeting to peroxisome [Evidence IEA]
AWJ20_866	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
AWJ20_868	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_869	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_870	RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_872	Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores; GO_component: GO:0000417 - HIR complex [Evidence IDA,IPI] [PMID 16264190]; GO_component: GO:0000417 - HIR complex [Evidence IDA] [PMID 16303565]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 11782447]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 9504914]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16264190]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0031491 - nucleosome binding [Evidence IMP] [PMID 16264190]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IDA] [PMID 9001207]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16264190]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16303565]; GO_process: GO:0016568 - chromatin modification [Evidence IEA,IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9001207]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 16449659]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_873	Vacuolar carboxypeptidase S; expression is induced under low-nitrogen conditions; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 1569061]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IMP] [PMID 2026161]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004181 - metallocarboxypeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IMP] [PMID 2026161]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IMP] [PMID 2026161]
AWJ20_874	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_876	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
AWJ20_880	Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 12486135]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 12486135]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12486135]
AWJ20_882	top hit is XP_002839470.1 originated in Tuber melanosporum Mel28; conserved fungal protein
AWJ20_883	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_885	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 8433986]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IMP] [PMID 8433986]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0006096 - glycolytic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_886	Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0004198 - calcium-dependent cysteine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IDA] [PMID 9928935]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0016485 - protein processing [Evidence IGI,IMP] [PMID 9928935]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_887	Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit; GO_component: GO:0005965 - protein farnesyltransferase complex [Evidence IEA]; GO_component: GO:0005965 - protein farnesyltransferase complex [Evidence IDA] [PMID 8424764]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0004660 - protein farnesyltransferase activity [Evidence IEA]; GO_function: GO:0004660 - protein farnesyltransferase activity [Evidence IDA] [PMID 9380709]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0018343 - protein farnesylation [Evidence IEA]; GO_process: GO:0018343 - protein farnesylation [Evidence IDA] [PMID 1763050]; GO_process: GO:0042127 - regulation of cell proliferation [Evidence IEA]
AWJ20_889	General splicing factor; required for stable U2 snRNP binding to primary transcripts; essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; similar to S. pombe Cwf24p; GO_component: GO:0005684 - U2-type spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17974558]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IPI] [PMID 23029180]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IMP] [PMID 22535589]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 23029180]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 17974558]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 23029180]
AWJ20_890	ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 9584156]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9724628]
AWJ20_892	Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IDA] [PMID 9769104]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IGI,IMP] [PMID 10999606]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17171376]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IGI,IMP] [PMID 10999606]; GO_process: GO:0000389 - mRNA 3'-splice site recognition [Evidence IGI] [PMID 10628969]; GO_process: GO:0000389 - mRNA 3'-splice site recognition [Evidence IGI] [PMID 15133121]; GO_process: GO:0000348 - mRNA branch site recognition [Evidence IGI] [PMID 15133121]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_893	Essential protein involved in nuclear export of Mss4p; Mss4p is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 12912920]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 12912920]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_894	Peroxisomal integral membrane protein; involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p; PEX30 has a paralog, PEX31, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 14617799]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007031 - peroxisome organization [Evidence IMP] [PMID 14617799]
AWJ20_896	Membrane protein required for translocation of Man5GlcNac2-PP-Dol; required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein; essential gene; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IGI,IMP] [PMID 11807558]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0034202 - glycolipid-translocating activity [Evidence IDA] [PMID 18597486]; GO_function: GO:0034202 - glycolipid-translocating activity [Evidence IDA] [PMID 18668045]; GO_function: GO:0034202 - glycolipid-translocating activity [Evidence IMP] [PMID 19494107]; GO_function: GO:0005319 - lipid transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0034203 - glycolipid translocation [Evidence IGI,IMP] [PMID 11807558]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_898	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 1394434]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 16413483]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9860955]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9670014]; GO_process: GO:0051083 - 'de novo' cotranslational protein folding [Evidence IDA] [PMID 9670014]; GO_process: GO:0042149 - cellular response to glucose starvation [Evidence IGI] [PMID 19723765]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP,IPI] [PMID 1394434]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 20368619]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 15456889]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IGI] [PMID 20368619]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 16607023]
AWJ20_899	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_900	Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family; GO_component: GO:0009898 - cytoplasmic side of plasma membrane [Evidence IDA] [PMID 20028738]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 9017390]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 9017390]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 9017390]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence ISA] [PMID 18976803]
AWJ20_901	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
AWJ20_902	Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0016592 - mediator complex [Evidence IDA] [PMID 19368889]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9671481]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9671481]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19368889]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_903	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16806052]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16806052]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 16806052]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 16702403]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_904	2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IDA,IMP] [PMID 17242307]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 17242307]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_908	ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9792709]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 16709151]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IEA]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IDA,ISS] [PMID 9792709]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IDA] [PMID 9792709]
AWJ20_909	GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19380492]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 9171383]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 19380492]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0051457 - maintenance of protein location in nucleus [Evidence IPI] [PMID 19380492]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI] [PMID 9106207]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI,IMP] [PMID 9171427]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_910	Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15781691]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]
AWJ20_911	Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]
AWJ20_912	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 14729968]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 14729968]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 2556404]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_913	Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15961382]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence ISS] [PMID 15961382]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IGI,IMP] [PMID 15961382]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IMP] [PMID 10978274]; GO_process: GO:0006829 - zinc ion transport [Evidence IGI,IMP] [PMID 15961382]
AWJ20_914	Anthranilate phosphoribosyl transferase; transferase of the tryptophan biosynthetic pathway; catalyzes the phosphoribosylation of anthranilate; subject to the general control system of amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004048 - anthranilate phosphoribosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004048 - anthranilate phosphoribosyltransferase activity [Evidence ISS] [PMID 2428012]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 10790693]
AWJ20_917	Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 10747088]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA,IMP] [PMID 18287542]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 15039776]; GO_function: GO:0043130 - ubiquitin binding [Evidence IMP] [PMID 19574226]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 15039776]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP,IPI] [PMID 10747088]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0043328 - protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 15039776]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_918	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15353583]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 12672825]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0043623 - cellular protein complex assembly [Evidence IMP] [PMID 18212047]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IPI] [PMID 12672825]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_921	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11726524]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15710377]; GO_component: GO:0017102 - methionyl glutamyl tRNA synthetase complex [Evidence IMP,IPI] [PMID 9659920]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 11069915]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0000049 - tRNA binding [Evidence IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IMP,IPI] [PMID 11726524]; GO_process: GO:0051351 - positive regulation of ligase activity [Evidence IDA] [PMID 11069915]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IMP] [PMID 9659920]
AWJ20_925	Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IDA] [PMID 10855721]; GO_process: GO:0006083 - acetate metabolic process [Evidence IDA] [PMID 10855721]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]
AWJ20_926	NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 19016485]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA,IMP] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_929	Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_930	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 3967297]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 6365930]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 8163554]; GO_component: GO:0005884 - actin filament [Evidence IDA] [PMID 6217414]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 3967297]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 6365930]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 8163554]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 3967297]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 8163554]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 10911987]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IDA] [PMID 6217414]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IDA,IMP] [PMID 9732290]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA] [PMID 17118118]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence TAS] [PMID 10652251]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17287397]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 15024029]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI] [PMID 9864365]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence TAS] [PMID 10652251]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10911987]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 10652251]; GO_process: GO:0009306 - protein secretion [Evidence IGI,IMP] [PMID 10793147]; GO_process: GO:0000011 - vacuole inheritance [Evidence IGI,IMP] [PMID 8978821]; GO_process: GO:0030050 - vesicle transport along actin filament [Evidence TAS] [PMID 10652251]
AWJ20_931	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_935	Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11029042]; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11029042]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 12194857]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP] [PMID 17130288]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 11029042]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_936	Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome; GO_component: GO:0055087 - Ski complex [Evidence IDA] [PMID 10744028]; GO_component: GO:0055087 - Ski complex [Evidence IDA,IPI] [PMID 18042677]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence ISS] [PMID 8321235]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0051607 - defense response to virus [Evidence IEA]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12769863]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 10611222]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 11910110]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 17660569]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]
AWJ20_937	Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome; GO_component: GO:0055087 - Ski complex [Evidence IDA] [PMID 10744028]; GO_component: GO:0055087 - Ski complex [Evidence IDA,IPI] [PMID 18042677]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence ISS] [PMID 8321235]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0051607 - defense response to virus [Evidence IEA]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12769863]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 10611222]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 11910110]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 17660569]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]
AWJ20_938	Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15001388]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19854152]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0004450 - isocitrate dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004450 - isocitrate dehydrogenase (NADP+) activity [Evidence IDA] [PMID 15574419]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA]; GO_process: GO:0006102 - isocitrate metabolic process [Evidence IEA]; GO_process: GO:0006102 - isocitrate metabolic process [Evidence IGI,IMP] [PMID 15574419]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
AWJ20_943	Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 3528153]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004329 - formate-tetrahydrofolate ligase activity [Evidence IEA,IEA]; GO_function: GO:0004329 - formate-tetrahydrofolate ligase activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity [Evidence IEA]; GO_function: GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IDA] [PMID 3528153]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IMP] [PMID 10781559]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
AWJ20_945	Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 3528153]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004329 - formate-tetrahydrofolate ligase activity [Evidence IEA,IEA]; GO_function: GO:0004329 - formate-tetrahydrofolate ligase activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity [Evidence IEA]; GO_function: GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IDA] [PMID 3528153]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IMP] [PMID 10781559]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
AWJ20_947	Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23285234]; GO_component: GO:0005829 - cytosol [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16390866]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23285234]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000753 - cell morphogenesis involved in conjugation with cellular fusion [Evidence IMP] [PMID 16390866]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IDA] [PMID 20850366]; GO_process: GO:0045048 - protein insertion into ER membrane [Evidence IGI] [PMID 19325107]
AWJ20_948	Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IEA]
AWJ20_949	Component of the mitotic spindle; binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]
AWJ20_952	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress; GO_component: GO:0035101 - FACT complex [Evidence IGI,IPI] [PMID 11432837]; GO_component: GO:0035101 - FACT complex [Evidence IDA] [PMID 9705338]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 10413469]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10413469]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10413469]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 18089575]; GO_function: GO:0031491 - nucleosome binding [Evidence IDA] [PMID 11432837]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0034724 - DNA replication-independent nucleosome organization [Evidence IDA] [PMID 15082784]; GO_process: GO:0034724 - DNA replication-independent nucleosome organization [Evidence IDA] [PMID 19683499]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IGI,IMP] [PMID 10924459]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IPI] [PMID 9199353]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA] [PMID 15987999]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IC] [PMID 19683500]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_953	Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11739806]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11739806]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 11739806]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11739806]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IGI] [PMID 7822420]; GO_process: GO:0032596 - protein transport into membrane raft [Evidence IMP,IPI] [PMID 11739806]
AWJ20_954	Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex; GO_component: GO:0030122 - AP-2 adaptor complex [Evidence IDA,IPI] [PMID 10564262]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 8157009]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IC] [PMID 10564262]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_955	Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17218313]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 8335627]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IDA,IMP] [PMID 17218313]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 17218313]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0015204 - urea transmembrane transporter activity [Evidence IMP,ISS] [PMID 8335627]; GO_process: GO:0015847 - putrescine transport [Evidence IDA,IMP] [PMID 17218313]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 17218313]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IEP] [PMID 8335627]; GO_process: GO:0015840 - urea transport [Evidence IMP,ISS] [PMID 8335627]
AWJ20_956	Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17218313]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 8335627]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IDA,IMP] [PMID 17218313]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 17218313]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0015204 - urea transmembrane transporter activity [Evidence IMP,ISS] [PMID 8335627]; GO_process: GO:0015847 - putrescine transport [Evidence IDA,IMP] [PMID 17218313]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 17218313]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IEP] [PMID 8335627]; GO_process: GO:0015840 - urea transport [Evidence IMP,ISS] [PMID 8335627]
AWJ20_959	Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 8628289]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20709757]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015369 - calcium:proton antiporter activity [Evidence IEA]; GO_function: GO:0015369 - calcium:proton antiporter activity [Evidence IMP] [PMID 20709757]; GO_function: GO:0015369 - calcium:proton antiporter activity [Evidence IDA,IMP] [PMID 8628289]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0015386 - potassium:proton antiporter activity [Evidence IMP] [PMID 20709757]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA,IMP] [PMID 8628289]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 8628289]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006828 - manganese ion transport [Evidence IDA] [PMID 15522090]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA,IMP] [PMID 8628289]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_962	Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 7973730]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 14688790]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14688790]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IDA] [PMID 7973730]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 7973730]; GO_process: GO:0032878 - regulation of establishment or maintenance of cell polarity [Evidence IGI,IPI] [PMID 17853895]; GO_process: GO:0031106 - septin ring organization [Evidence IGI] [PMID 19458192]
AWJ20_963	Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 15591131]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15591131]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 15591131]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 15591131]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 15591131]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_964	Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity; GO_component: GO:0031011 - Ino80 complex [Evidence IEA]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11011149]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 17320816]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 12887900]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 23644470]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 17320816]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_966	polyprotein of non-LTR retrotransposon Zorro 1 and repeat region-related DNA
AWJ20_968	Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0043625 - delta DNA polymerase complex [Evidence TAS] [PMID 9745046]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 18635534]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence TAS] [PMID 9745046]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008310 - single-stranded DNA 3'-5' exodeoxyribonuclease activity [Evidence TAS] [PMID 9745046]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IDA] [PMID 16837458]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IDA] [PMID 17429354]; GO_process: GO:0006284 - base-excision repair [Evidence TAS] [PMID 9745046]; GO_process: GO:0006273 - lagging strand elongation [Evidence TAS] [PMID 9745046]; GO_process: GO:0006272 - leading strand elongation [Evidence TAS] [PMID 9745046]; GO_process: GO:0006298 - mismatch repair [Evidence TAS] [PMID 10072354]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence TAS] [PMID 9745046]; GO_process: GO:0006301 - postreplication repair [Evidence TAS] [PMID 9745046]
AWJ20_969	Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 2645139]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004825 - methionine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004825 - methionine-tRNA ligase activity [Evidence IMP,ISS] [PMID 2645139]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006431 - methionyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006431 - methionyl-tRNA aminoacylation [Evidence IMP,ISS] [PMID 2645139]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_972	Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11687631]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11742990]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11752412]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11742990]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IMP] [PMID 11752412]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA,IMP] [PMID 11805083]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11687631]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11805083]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11742990]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11752412]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11805083]; GO_process: GO:0080182 - histone H3-K4 trimethylation [Evidence IMP] [PMID 16921172]; GO_process: GO:0080182 - histone H3-K4 trimethylation [Evidence IMP] [PMID 16980427]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 11742990]
AWJ20_973	Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IMP,ISS] [PMID 12052881]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 15256499]; GO_function: GO:0005034 - osmosensor activity [Evidence IMP] [PMID 12052881]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 19439450]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI] [PMID 2690082]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 17627274]; GO_process: GO:0007232 - osmosensory signaling pathway via Sho1 osmosensor [Evidence IGI] [PMID 17627274]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 12052881]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IEP,IGI,IMP] [PMID 15256499]
AWJ20_974	Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 11565790]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004121 - cystathionine beta-lyase activity [Evidence IEA,IEA]; GO_function: GO:0004121 - cystathionine beta-lyase activity [Evidence IMP,ISS] [PMID 10821189]; GO_function: GO:0004121 - cystathionine beta-lyase activity [Evidence IDA] [PMID 21478306]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0071266 - 'de novo' L-methionine biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 10821189]; GO_process: GO:0019346 - transsulfuration [Evidence IMP] [PMID 10821189]
AWJ20_975	ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p; GO_component: GO:0030126 - COPI vesicle coat [Evidence IPI] [PMID 15254269]; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 15254269]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment [Evidence IPI] [PMID 9927415]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IDA] [PMID 9927415]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0048205 - COPI coating of Golgi vesicle [Evidence IDA,IMP] [PMID 15254269]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 9927415]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032312 - regulation of ARF GTPase activity [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA,IGI,IMP] [PMID 9927415]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_977	Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 1544898]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 1544898]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 1544898]
AWJ20_978	Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 11466296]; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 17482543]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0047724 - inosine nucleosidase activity [Evidence IDA] [PMID 19001417]; GO_function: GO:0070635 - nicotinamide riboside hydrolase activity [Evidence IDA] [PMID 19001417]; GO_function: GO:0004731 - purine-nucleoside phosphorylase activity [Evidence IEA,IEA]; GO_function: GO:0004731 - purine-nucleoside phosphorylase activity [Evidence IDA,IMP,ISS] [PMID 11466296]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_process: GO:0034356 - NAD biosynthesis via nicotinamide riboside salvage pathway [Evidence IGI] [PMID 19001417]; GO_process: GO:0046115 - guanosine catabolic process [Evidence IMP] [PMID 11466296]; GO_process: GO:0046115 - guanosine catabolic process [Evidence IMP] [PMID 23670538]; GO_process: GO:0006148 - inosine catabolic process [Evidence IMP] [PMID 11466296]; GO_process: GO:0006148 - inosine catabolic process [Evidence IMP] [PMID 23670538]; GO_process: GO:0019358 - nicotinate nucleotide salvage [Evidence IGI] [PMID 17482543]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]
AWJ20_979	Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 11717432]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 12671686]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 17604721]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 22300850]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 8223424]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 8432727]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12538638]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 10747086]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IDA] [PMID 11389436]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA] [PMID 15817685]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_980	Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH; GO_component: GO:0000439 - core TFIIH complex [Evidence IEA]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IPI] [PMID 10681587]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 19897425]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 9235928]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_981	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 24206665]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 24206665]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12702275]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 24206665]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 9046088]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:1990400 - mitochondrial ribosomal large subunit rRNA binding [Evidence IDA] [PMID 24206665]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0016070 - RNA metabolic process [Evidence IMP] [PMID 12702275]; GO_process: GO:1902775 - mitochondrial large ribosomal subunit assembly [Evidence IMP] [PMID 24206665]
AWJ20_982	Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0048500 - signal recognition particle [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IDA] [PMID 7925282]; GO_function: GO:0008312 - 7S RNA binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IPI] [PMID 7925282]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IEA]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence IC] [PMID 7925282]; GO_process: GO:0045047 - protein targeting to ER [Evidence IPI] [PMID 7925282]
AWJ20_983	Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9271378]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9271378]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9271378]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 9271378]; GO_process: GO:0042255 - ribosome assembly [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_984	tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA; PUS1 has a paralog, PUS2, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 8641292]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA] [PMID 10356324]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IMP] [PMID 10022901]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA] [PMID 10356324]
AWJ20_985	Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; GO_component: GO:0030690 - Noc1p-Noc2p complex [Evidence IPI] [PMID 11371346]; GO_component: GO:0030691 - Noc2p-Noc3p complex [Evidence IPI] [PMID 11371346]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23209026]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 23209026]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_986	Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070628 - proteasome binding [Evidence IDA] [PMID 24121501]; GO_function: GO:0070628 - proteasome binding [Evidence IDA] [PMID 24297164]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071243 - cellular response to arsenic-containing substance [Evidence IGI,IMP] [PMID 24297164]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP,IPI] [PMID 24121501]
AWJ20_987	Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 15797382]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 15878866]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 15797382]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_988	Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15221522]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence ISS] [PMID 9445368]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 15221522]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_990	Enhanced Adherence to Polystyrene; similar to S. pombe predicted GPI-anchored SPBPJ4664.02; similar to RBT1; internal hexapeptide PATEST repeat region is expanded in allelic CaP19.8979; identical to C. albicans morphogenetic related gene CPH3 (AAM46085); no clear allele
AWJ20_991	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 8413233]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006078 - (1->6)-beta-D-glucan biosynthetic process [Evidence IEA]; GO_process: GO:0006077 - (1->6)-beta-D-glucan metabolic process [Evidence IMP] [PMID 8413233]; GO_process: GO:0042546 - cell wall biogenesis [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 8413233]
AWJ20_993	Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 8308064]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence TAS] [PMID 8308064]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 23656787]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_994	Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15282802]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 8846915]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 8846915]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 8846915]
AWJ20_995	GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8862519]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 8862519]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0050185 - phosphatidylinositol deacylase activity [Evidence IGI] [PMID 14734546]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8862519]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11673477]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IEA]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IGI] [PMID 14734546]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 8862519]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IGI,IMP] [PMID 8862519]
AWJ20_998	Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; GO_component: GO:0030015 - CCR4-NOT core complex [Evidence IPI] [PMID 10490603]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11889048]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16926149]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 19346402]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0031087 - deadenylation-independent decapping of nuclear-transcribed mRNA [Evidence IMP] [PMID 15706350]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 11404327]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA,IPI] [PMID 21406554]; GO_process: GO:0010498 - proteasomal protein catabolic process [Evidence IGI] [PMID 24261871]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA,IMP] [PMID 19346402]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 16926149]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1000	EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 10594004]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence TAS] [PMID 10652251]; GO_process: GO:0007015 - actin filament organization [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 15944351]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 10652251]; GO_process: GO:0006897 - endocytosis [Evidence IEA,IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8380177]
AWJ20_1001	ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 20841378]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8816753]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20444982]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_1002	Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 18632794]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 7775427]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0004520 - endodeoxyribonuclease activity [Evidence TAS] [PMID 1534148]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0046034 - ATP metabolic process [Evidence IEA]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IDA] [PMID 8508780]; GO_process: GO:0016539 - intein-mediated protein splicing [Evidence IEA]; GO_process: GO:0006314 - intron homing [Evidence IEA]; GO_process: GO:0006314 - intron homing [Evidence TAS] [PMID 1534148]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0030908 - protein splicing [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 18048916]
AWJ20_1003	Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IDA] [PMID 17550305]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IMP] [PMID 2176150]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 12518319]; GO_process: GO:0007015 - actin filament organization [Evidence TAS] [PMID 9001215]; GO_process: GO:0007117 - budding cell bud growth [Evidence TAS] [PMID 9001215]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IPI] [PMID 9001215]; GO_process: GO:0006470 - protein dephosphorylation [Evidence TAS] [PMID 9001215]; GO_process: GO:0006417 - regulation of translation [Evidence IPI] [PMID 10329624]
AWJ20_1004	Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IDA] [PMID 17550305]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IMP] [PMID 2176150]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 12518319]; GO_process: GO:0007015 - actin filament organization [Evidence TAS] [PMID 9001215]; GO_process: GO:0007117 - budding cell bud growth [Evidence TAS] [PMID 9001215]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IPI] [PMID 9001215]; GO_process: GO:0006470 - protein dephosphorylation [Evidence TAS] [PMID 9001215]; GO_process: GO:0006417 - regulation of translation [Evidence IPI] [PMID 10329624]
AWJ20_1005	Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15108020]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 15108020]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10066831]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005094 - Rho GDP-dissociation inhibitor activity [Evidence IEA]; GO_function: GO:0005094 - Rho GDP-dissociation inhibitor activity [Evidence IDA] [PMID 10066831]; GO_process: GO:0007015 - actin filament organization [Evidence IDA,IMP] [PMID 9242378]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IDA] [PMID 11598008]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IPI] [PMID 10066831]
AWJ20_1007	Ubiquitin chain assembly factor (E4); cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000151 - ubiquitin ligase complex [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0034450 - ubiquitin-ubiquitin ligase activity [Evidence IEA]; GO_function: GO:0034450 - ubiquitin-ubiquitin ligase activity [Evidence IDA] [PMID 10089879]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21148305]; GO_process: GO:0071361 - cellular response to ethanol [Evidence IMP] [PMID 10089879]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA,IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 10089879]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP,IPI] [PMID 10089879]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 7615550]
AWJ20_1008	Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISS] [PMID 9388293]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IEA]; GO_function: GO:0004314 - [acyl-carrier-protein] S-malonyltransferase activity [Evidence IMP,ISS] [PMID 9388293]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9388293]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IMP,ISS] [PMID 9388293]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1009	hypothetical protein; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10366589]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 15623581]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IDA] [PMID 10366589]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 10366589]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 15623581]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1010	Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11779510]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11779510]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0042256 - mature ribosome assembly [Evidence IMP] [PMID 11779510]; GO_process: GO:0042256 - mature ribosome assembly [Evidence ISO] [PMID 21536732]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1013	Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN); GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12628189]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12628189]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12628189]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12628189]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007093 - mitotic cell cycle checkpoint [Evidence IMP] [PMID 12628189]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0001100 - negative regulation of exit from mitosis [Evidence IGI,IMP] [PMID 12628189]
AWJ20_1014	hypothetical protein; has strong similarity to alanyl-tRNA synthases from Eubacteria; null mutant displays decreased translation rate and increased readthrough of premature stop codons; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004813 - alanine-tRNA ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006419 - alanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1016	Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12087109]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0009922 - fatty acid elongase activity [Evidence IMP] [PMID 12684876]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0030497 - fatty acid elongation [Evidence IMP] [PMID 9211877]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 9211877]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 9832547]
AWJ20_1018	Subunit of the Set3C deacetylase complex; interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IPI] [PMID 11711434]; GO_process: GO:0032874 - positive regulation of stress-activated MAPK cascade [Evidence IMP] [PMID 18487345]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 19379692]
AWJ20_1019	Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_function: GO:0008902 - hydroxymethylpyrimidine kinase activity [Evidence IGI] [PMID 15614489]; GO_function: GO:0008972 - phosphomethylpyrimidine kinase activity [Evidence ISA] [PMID 10383756]; GO_function: GO:0008972 - phosphomethylpyrimidine kinase activity [Evidence IGI] [PMID 15614489]; GO_function: GO:0050334 - thiaminase activity [Evidence IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IEP] [PMID 10383756]; GO_process: GO:0006772 - thiamine metabolic process [Evidence IEA]
AWJ20_1020	Zinc-finger hypothetical protein; possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; STP3 has a paralog, STP4, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IDA] [PMID 19111667]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1021	potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUKM subunit and mammalian PSST, CI-20kd or NDUFS7 subunit; allele of CaO19.6794
AWJ20_1022	Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 19129178]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence IEA]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006073 - cellular glucan metabolic process [Evidence IGI,IMP] [PMID 7565587]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence ISS] [PMID 9748433]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1023	Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051293 - establishment of spindle localization [Evidence IGI,IMP] [PMID 22385961]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 16888627]; GO_process: GO:0045132 - meiotic chromosome segregation [Evidence IMP] [PMID 16888627]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000073 - spindle pole body separation [Evidence IMP] [PMID 22385961]
AWJ20_1024	Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 8841414]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8841414]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0050203 - oxalate-CoA ligase activity [Evidence IDA,IMP] [PMID 24291261]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0033611 - oxalate catabolic process [Evidence IDA,IMP] [PMID 24291261]
AWJ20_1025	Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004039 - allophanate hydrolase activity [Evidence IEA]; GO_function: GO:0004039 - allophanate hydrolase activity [Evidence IMP] [PMID 6105114]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IEA]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA]; GO_function: GO:0004847 - urea carboxylase activity [Evidence IEA]; GO_function: GO:0004847 - urea carboxylase activity [Evidence IMP] [PMID 6105114]; GO_process: GO:0000256 - allantoin catabolic process [Evidence TAS] [PMID 1938916]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IMP] [PMID 6105114]
AWJ20_1030	Protein that negatively regulates mitotic exit; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; KEL2 has a paralog, KEL1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9786949]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9786949]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9786949]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IGI] [PMID 9786949]; GO_process: GO:0001100 - negative regulation of exit from mitosis [Evidence IMP,IPI] [PMID 12234925]
AWJ20_1033	one of two likely delta-12 fatty acid desaturases similar to E.nudulans OdeA; conversion of oleic acid to linoleic acid, psi factor production; allele of CaO19.118
AWJ20_1034	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9891085]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9891085]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 9891085]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12364597]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IMP] [PMID 19369424]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18940861]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 12364597]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_1035	Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 10051608]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 10397776]; GO_component: GO:0042719 - mitochondrial intermembrane space protein transporter complex [Evidence IPI] [PMID 10051608]; GO_component: GO:0042719 - mitochondrial intermembrane space protein transporter complex [Evidence IDA] [PMID 12221072]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 10051608]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA,IMP] [PMID 10469659]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IDA] [PMID 10051608]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IDA,IMP] [PMID 10469659]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1036	Putative ribokinase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence ISS] [PMID 1964349]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0004747 - ribokinase activity [Evidence IEA,IEA]; GO_function: GO:0004747 - ribokinase activity [Evidence ISS] [PMID 1964349]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019303 - D-ribose catabolic process [Evidence IEA]; GO_process: GO:0006014 - D-ribose metabolic process [Evidence IEA]; GO_process: GO:0006014 - D-ribose metabolic process [Evidence ISS] [PMID 1964349]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_1037	Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence TAS] [PMID 8982460]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_1038	Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence TAS] [PMID 8982460]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_1040	Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15828860]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IBA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISS] [PMID 9858558]; GO_process: GO:0016567 - protein ubiquitination [Evidence ISS] [PMID 9858558]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]
AWJ20_1041	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15454531]; GO_function: GO:0017057 - 6-phosphogluconolactonase activity [Evidence IDA] [PMID 15454531]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP] [PMID 15454531]
AWJ20_1043	Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP; GO_component: GO:0032301 - MutSalpha complex [Evidence IEA]; GO_component: GO:0032301 - MutSalpha complex [Evidence IPI] [PMID 8816473]; GO_component: GO:0032302 - MutSbeta complex [Evidence IEA]; GO_component: GO:0032302 - MutSbeta complex [Evidence IPI] [PMID 8805366]; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 10882115]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 9545323]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9819445]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0032135 - DNA insertion or deletion binding [Evidence IDA] [PMID 8805366]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IBA]; GO_function: GO:0000403 - Y-form DNA binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0003684 - damaged DNA binding [Evidence IBA]; GO_function: GO:0000406 - double-strand/single-strand DNA junction binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 10066781]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 9018043]; GO_function: GO:0032137 - guanine/thymine mispair binding [Evidence IDA] [PMID 8816473]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032138 - single base insertion or deletion binding [Evidence IDA] [PMID 8816473]; GO_function: GO:0032138 - single base insertion or deletion binding [Evidence IMP] [PMID 9111312]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 15920474]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 16157874]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IBA]; GO_process: GO:0006311 - meiotic gene conversion [Evidence IMP] [PMID 1334021]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 1334021]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 8056309]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 10523644]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 9520271]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 8849883]; GO_process: GO:0045128 - negative regulation of reciprocal meiotic recombination [Evidence IBA]; GO_process: GO:0006301 - postreplication repair [Evidence IBA]; GO_process: GO:0000735 - removal of nonhomologous ends [Evidence IMP] [PMID 10523644]; GO_process: GO:0000735 - removal of nonhomologous ends [Evidence IGI,IMP] [PMID 9256462]
AWJ20_1045	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1046	Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1048	Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10848632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10848632]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 7493987]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 8422683]; GO_process: GO:0071400 - cellular response to oleic acid [Evidence IMP] [PMID 12393187]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IDA] [PMID 7493987]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 8422683]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12393187]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 7493987]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8422683]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1051	Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15145942]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15145942]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033108 - mitochondrial respiratory chain complex assembly [Evidence IMP] [PMID 19703468]
AWJ20_1054	3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IEA]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IDA,ISS] [PMID 12697341]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12697341]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006574 - valine catabolic process [Evidence IEA]
AWJ20_1056	Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 18427809]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 18427809]; GO_function: GO:0004092 - carnitine O-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004092 - carnitine O-acetyltransferase activity [Evidence IMP,ISS] [PMID 8420957]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0009437 - carnitine metabolic process [Evidence IMP] [PMID 11329169]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1057	Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A; GO_component: GO:0043189 - H4/H2A histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15353583]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 15353583]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IPI] [PMID 15353583]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 15353583]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP,IPI] [PMID 15353583]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1059	Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; GO_component: GO:0032044 - DSIF complex [Evidence IPI] [PMID 9450930]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1840633]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 16908835]; GO_function: GO:0001042 - RNA polymerase I core binding [Evidence IPI] [PMID 21467036]; GO_function: GO:0001179 - RNA polymerase I transcription factor binding [Evidence IPI] [PMID 21467036]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 9450930]; GO_function: GO:0001181 - core RNA polymerase I binding transcription factor activity [Evidence IC] [PMID 21467036]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IGI,IMP,IPI] [PMID 9450930]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 21467036]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IGI,IPI] [PMID 12556496]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 20713510]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 12556496]; GO_process: GO:2001208 - negative regulation of transcription elongation from RNA polymerase I promoter [Evidence IGI] [PMID 21467039]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IMP] [PMID 21467039]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 19365074]; GO_process: GO:0032784 - regulation of DNA-templated transcription, elongation [Evidence IEA]; GO_process: GO:2000232 - regulation of rRNA processing [Evidence IMP] [PMID 21949810]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 20042611]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1060	Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; expression is regulated by stress-response elements and by the HOG MAP kinase pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24146988]; GO_function: GO:0008184 - glycogen phosphorylase activity [Evidence IEA]; GO_function: GO:0008184 - glycogen phosphorylase activity [Evidence IMP] [PMID 2657401]; GO_function: GO:0004645 - phosphorylase activity [Evidence IEA,IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0005980 - glycogen catabolic process [Evidence IMP] [PMID 2657401]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]
AWJ20_1063	Subunit beta of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
AWJ20_1064	Sorting nexin family member; required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12554655]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 12048214]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 12048214]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 15659643]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_component: GO:0034045 - pre-autophagosomal structure membrane [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 12048214]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 12554655]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IGI,IMP,IPI] [PMID 12554655]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 12048214]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1065	FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 17298444]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17298444]; GO_function: GO:0052874 - FMN reductase (NADH) activity [Evidence IEA]; GO_function: GO:0052873 - FMN reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0003955 - NAD(P)H dehydrogenase (quinone) activity [Evidence IDA,IMP] [PMID 17298444]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008134 - transcription factor binding [Evidence IDA] [PMID 19029946]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 19709309]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17298444]; GO_process: GO:0042994 - cytoplasmic sequestering of transcription factor [Evidence IDA] [PMID 19029946]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_1066	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 9844636]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 9726966]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 9844636]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11011149]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA,IDA] [PMID 12183366]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006325 - chromatin organization [Evidence IGI] [PMID 12805231]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 17496903]; GO_process: GO:0016584 - nucleosome positioning [Evidence IMP] [PMID 21343911]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9726966]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1068	Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress; GO_component: GO:0000785 - chromatin [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IPI] [PMID 9990856]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16962805]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0016407 - acetyltransferase activity [Evidence IDA] [PMID 11864574]; GO_function: GO:0016407 - acetyltransferase activity [Evidence IDA] [PMID 18614053]; GO_function: GO:0016407 - acetyltransferase activity [Evidence IDA,IMP] [PMID 22593213]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9990856]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 11448778]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 9990856]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IMP] [PMID 19948494]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 11448778]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IGI] [PMID 16934511]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IMP] [PMID 9990855]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IMP] [PMID 9990856]; GO_process: GO:0018393 - internal peptidyl-lysine acetylation [Evidence IDA] [PMID 18614053]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 19948494]; GO_process: GO:0034421 - post-translational protein acetylation [Evidence IEA]; GO_process: GO:0006275 - regulation of DNA replication [Evidence IEA]; GO_process: GO:0006275 - regulation of DNA replication [Evidence IGI] [PMID 9990855]; GO_process: GO:0007088 - regulation of mitosis [Evidence IMP] [PMID 9990855]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IEA]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 19948494]; GO_process: GO:0032200 - telomere organization [Evidence IMP] [PMID 19948494]
AWJ20_1069	Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0046820 - 4-amino-4-deoxychorismate synthase activity [Evidence IEA]; GO_function: GO:0046820 - 4-amino-4-deoxychorismate synthase activity [Evidence IMP,ISS] [PMID 8346682]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016833 - oxo-acid-lyase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0008153 - para-aminobenzoic acid biosynthetic process [Evidence IMP] [PMID 8346682]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA]
AWJ20_1070	Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
AWJ20_1071	potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to N. crassa and mammalian 40kd subunits; allele of CaO19.1682
AWJ20_1072	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; may control nonselective autophagy and mitophagy through trafficking of Atg9p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10587649]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16365163]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8194527]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 10587649]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16365163]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IEA,IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IMP] [PMID 10587649]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA] [PMID 8194527]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA] [PMID 8248783]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006661 - phosphatidylinositol biosynthetic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IMP] [PMID 10587649]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 8194527]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 8248783]; GO_process: GO:0048015 - phosphatidylinositol-mediated signaling [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_1074	Vacuolar protein sorting (VPS) protein; required for cytoplasm to vacuole targeting of proteins; VPS62 has a paralog, TDA6, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1075	Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_1078	Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0032133 - chromosome passenger complex [Evidence IDA] [PMID 19158380]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IDA] [PMID 11724818]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11724818]; GO_component: GO:0051233 - spindle midzone [Evidence IDA] [PMID 12566427]; GO_function: GO:0030295 - protein kinase activator activity [Evidence IMP,IPI] [PMID 10385519]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence TAS] [PMID 11724818]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP,IPI] [PMID 10385519]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 17504936]; GO_process: GO:0032465 - regulation of cytokinesis [Evidence IMP] [PMID 16615892]
AWJ20_1079	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 9819421]; GO_function: GO:0030544 - Hsp70 protein binding [Evidence IDA] [PMID 15044454]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 12788914]; GO_process: GO:0006457 - protein folding [Evidence IPI] [PMID 15044454]; GO_process: GO:0006457 - protein folding [Evidence IGI] [PMID 9819421]
AWJ20_1081	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0016592 - mediator complex [Evidence IDA] [PMID 11383511]; GO_component: GO:0016592 - mediator complex [Evidence IDA] [PMID 12200444]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001105 - RNA polymerase II transcription coactivator activity [Evidence IDA,IMP] [PMID 20505076]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16109375]; GO_process: GO:0000411 - positive regulation of transcription by galactose [Evidence IMP] [PMID 15601835]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15601835]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1083	Proliferating cell nuclear antigen (PCNA); functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; GO_component: GO:0043626 - PCNA complex [Evidence IEA]; GO_component: GO:0043626 - PCNA complex [Evidence IPI] [PMID 8001157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005657 - replication fork [Evidence IDA] [PMID 12015307]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0030337 - DNA polymerase processivity factor activity [Evidence IEA]; GO_function: GO:0030337 - DNA polymerase processivity factor activity [Evidence IDA] [PMID 18635534]; GO_function: GO:0030337 - DNA polymerase processivity factor activity [Evidence IDA] [PMID 2902631]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 10545450]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16157874]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 16157874]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IGI] [PMID 19264809]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IGI] [PMID 16934511]; GO_process: GO:0006273 - lagging strand elongation [Evidence IDA,IPI] [PMID 7673186]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1682321]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IGI,IMP] [PMID 16079237]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IGI,IMP] [PMID 18245822]; GO_process: GO:0006298 - mismatch repair [Evidence IMP,IPI] [PMID 8858149]; GO_process: GO:0006298 - mismatch repair [Evidence IGI] [PMID 8910404]; GO_process: GO:0006298 - mismatch repair [Evidence IGI] [PMID 9504910]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IGI] [PMID 7516465]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IPI] [PMID 16934511]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 9806417]; GO_process: GO:1902394 - positive regulation of exodeoxyribonuclease activity [Evidence IDA] [PMID 12192046]; GO_process: GO:1903022 - positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [Evidence IDA] [PMID 12192046]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IMP] [PMID 8790390]; GO_process: GO:0006275 - regulation of DNA replication [Evidence IEA]
AWJ20_1084	Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0097373 - MCM core complex [Evidence IDA] [PMID 13679365]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 15723534]; GO_function: GO:1990163 - ATP-dependent four-way junction helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 15723534]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IPI] [PMID 9335335]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 13679365]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 15723534]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]
AWJ20_1085	hypothetical protein that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog, STF2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1086	Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IEA]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IDA] [PMID 8135547]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IEA]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IMP] [PMID 11827175]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IPI] [PMID 8135547]; GO_function: GO:0030291 - protein serine/threonine kinase inhibitor activity [Evidence IDA] [PMID 18265947]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 11551505]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 16607517]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16952051]; GO_process: GO:0045859 - regulation of protein kinase activity [Evidence IEA]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IDA] [PMID 11551505]; GO_process: GO:0006359 - regulation of transcription from RNA polymerase III promoter [Evidence IDA] [PMID 11551505]
AWJ20_1088	Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IEA]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IDA] [PMID 19342587]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0008793 - aromatic-amino-acid:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0008793 - aromatic-amino-acid:2-oxoglutarate aminotransferase activity [Evidence IDA] [PMID 9491082]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0009094 - L-phenylalanine biosynthetic process [Evidence IEA]; GO_process: GO:0009072 - aromatic amino acid family metabolic process [Evidence IGI,IMP] [PMID 9491083]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0006571 - tyrosine biosynthetic process [Evidence IEA]
AWJ20_1089	Activator of anaphase-promoting complex/cyclosome (APC/C); cell-cycle regulated; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IPI] [PMID 9831566]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12456658]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12456658]; GO_function: GO:0010997 - anaphase-promoting complex binding [Evidence IDA] [PMID 15916961]; GO_function: GO:0030332 - cyclin binding [Evidence IDA] [PMID 11566880]; GO_function: GO:0097027 - ubiquitin-protein transferase activator activity [Evidence IDA] [PMID 19362536]; GO_process: GO:0007092 - activation of mitotic anaphase-promoting complex activity [Evidence IMP] [PMID 9334304]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0010697 - negative regulation of spindle pole body separation [Evidence IGI,IMP] [PMID 16688214]; GO_process: GO:2000600 - positive regulation of cyclin catabolic process [Evidence IDA] [PMID 17178718]; GO_process: GO:0045842 - positive regulation of mitotic metaphase/anaphase transition [Evidence IMP] [PMID 9831566]; GO_process: GO:2000060 - positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 18172166]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]
AWJ20_1090	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 17603111]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 14597621]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 18431499]; GO_process: GO:0000915 - actomyosin contractile ring assembly [Evidence IMP] [PMID 17603111]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 17603111]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0032186 - cellular bud neck septin ring organization [Evidence IMP] [PMID 12636916]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 12699621]; GO_process: GO:0000921 - septin ring assembly [Evidence IGI] [PMID 17603111]
AWJ20_1091	Mitochondrial tryptophanyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 2999114]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004830 - tryptophan-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004830 - tryptophan-tRNA ligase activity [Evidence IMP,ISA] [PMID 2999114]; GO_process: GO:0070183 - mitochondrial tryptophanyl-tRNA aminoacylation [Evidence IMP] [PMID 2999114]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006436 - tryptophanyl-tRNA aminoacylation [Evidence IEA]
AWJ20_1093	Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p); GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 16207709]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 16207709]; GO_process: GO:0018063 - cytochrome c-heme linkage [Evidence IGI] [PMID 14514677]; GO_process: GO:0018063 - cytochrome c-heme linkage [Evidence IGI] [PMID 16207709]; GO_process: GO:0007006 - mitochondrial membrane organization [Evidence IMP] [PMID 11488609]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1094	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein; GO_component: GO:0097361 - CIA complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16314508]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16314508]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IGI,IMP] [PMID 17937914]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_1095	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein; GO_component: GO:0097361 - CIA complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16314508]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16314508]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IGI,IMP] [PMID 17937914]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_1097	Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 15056729]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IPI] [PMID 14690591]; GO_process: GO:0006364 - rRNA processing [Evidence IMP,IPI] [PMID 15056729]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1098	B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12388751]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12636916]; GO_component: GO:0000780 - condensed nuclear chromosome, centromeric region [Evidence IDA] [PMID 16541024]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000776 - kinetochore [Evidence IDA] [PMID 12636916]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12388751]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12636916]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12388751]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IDA] [PMID 9079645]; GO_process: GO:0032186 - cellular bud neck septin ring organization [Evidence IGI,IMP] [PMID 12636916]; GO_process: GO:0034613 - cellular protein localization [Evidence IMP] [PMID 19605686]; GO_process: GO:0051754 - meiotic sister chromatid cohesion, centromeric [Evidence IMP] [PMID 16541024]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IGI] [PMID 19605686]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 19605686]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 22581371]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0031107 - septin ring disassembly [Evidence IMP] [PMID 12636916]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_1099	Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication; GO_component: GO:0071563 - Myo2p-Vac17p-Vac8p transport complex [Evidence IPI] [PMID 12594460]; GO_component: GO:0032432 - actin filament bundle [Evidence IMP] [PMID 9864365]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8188749]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8188749]; GO_component: GO:0031941 - filamentous actin [Evidence IDA] [PMID 11381095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8978821]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8188749]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 8188749]; GO_component: GO:0031475 - myosin V complex [Evidence ISS] [PMID 1469047]; GO_component: GO:0016459 - myosin complex [Evidence IEA,IEA]; GO_component: GO:0030133 - transport vesicle [Evidence IDA] [PMID 23079598]; GO_component: GO:0031982 - vesicle [Evidence IDA] [PMID 12456647]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 11381095]; GO_function: GO:0005516 - calmodulin binding [Evidence IEA]; GO_function: GO:0005516 - calmodulin binding [Evidence IDA] [PMID 8294515]; GO_function: GO:0000146 - microfilament motor activity [Evidence IDA] [PMID 11381095]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0048313 - Golgi inheritance [Evidence IMP] [PMID 11285273]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IMP] [PMID 2016335]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IMP,IPI] [PMID 10984058]; GO_process: GO:0007107 - membrane addition at site of cytokinesis [Evidence IEP,IGI,IMP] [PMID 12456647]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IMP] [PMID 12391144]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IPI] [PMID 15201867]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IMP] [PMID 11733545]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IPI] [PMID 16678774]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0009826 - unidimensional cell growth [Evidence IMP] [PMID 9864365]; GO_process: GO:0000011 - vacuole inheritance [Evidence IGI,IPI] [PMID 12594460]; GO_process: GO:0000011 - vacuole inheritance [Evidence IGI,IMP] [PMID 8978821]; GO_process: GO:0030050 - vesicle transport along actin filament [Evidence IEP,IMP] [PMID 10562281]; GO_process: GO:0030050 - vesicle transport along actin filament [Evidence IEP,IMP] [PMID 9864365]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 2016335]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 9864365]
AWJ20_1100	Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IGI] [PMID 8336705]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IPI] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IGI] [PMID 8336705]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI] [PMID 8164676]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI,IPI] [PMID 8887689]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP] [PMID 9032257]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 8506384]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 2038326]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IGI] [PMID 8336705]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0045947 - negative regulation of translational initiation [Evidence IBA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI] [PMID 8164676]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IPI] [PMID 8887689]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 9032257]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_1101	H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF; GO_component: GO:0005960 - glycine cleavage complex [Evidence IEA]; GO_component: GO:0005960 - glycine cleavage complex [Evidence ISA] [PMID 9020168]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19570983]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IMP,ISA] [PMID 9020168]; GO_process: GO:0006546 - glycine catabolic process [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IMP] [PMID 9020168]; GO_process: GO:0019464 - glycine decarboxylation via glycine cleavage system [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI] [PMID 10871621]; GO_process: GO:0009249 - protein lipoylation [Evidence IMP] [PMID 19570983]
AWJ20_1102	Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IEA,IEA]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence NAS] [PMID 15494396]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence NAS] [PMID 15494396]; GO_process: GO:0006000 - fructose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006110 - regulation of glycolytic process [Evidence NAS] [PMID 15494396]
AWJ20_1103	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16717099]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9046099]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015230 - FAD transmembrane transporter activity [Evidence ISS] [PMID 16717099]; GO_process: GO:0015883 - FAD transport [Evidence ISS] [PMID 16717099]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 16717099]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1104	Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IPI] [PMID 12221113]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IPI] [PMID 10704439]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IDA,IPI] [PMID 11726501]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IGI] [PMID 16651657]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence TAS] [PMID 9448456]
AWJ20_1105	C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0000249 - C-22 sterol desaturase activity [Evidence IDA] [PMID 8543054]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8543054]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 8635732]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
AWJ20_1106	7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 10333520]; GO_function: GO:0004015 - adenosylmethionine-8-amino-7-oxononanoate transaminase activity [Evidence IEA,IEA]; GO_function: GO:0004015 - adenosylmethionine-8-amino-7-oxononanoate transaminase activity [Evidence IDA,ISS] [PMID 10333520]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IDA,IMP] [PMID 10333520]
AWJ20_1108	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1109	RNA polymerase III subunit C31; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 2201900]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006384 - transcription initiation from RNA polymerase III promoter [Evidence IMP] [PMID 7835345]
AWJ20_1111	Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23047103]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015809 - arginine transport [Evidence IGI,IMP] [PMID 23047103]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1118	Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR); GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 11493598]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016971 - flavin-linked sulfhydryl oxidase activity [Evidence IDA] [PMID 10899311]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016972 - thiol oxidase activity [Evidence IEA,IEA]; GO_function: GO:0016972 - thiol oxidase activity [Evidence IMP] [PMID 15989955]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IDA] [PMID 11493598]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15989955]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 15989955]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 16181637]
AWJ20_1119	Proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP); GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 9412475]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9412475]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9412475]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IPI] [PMID 9412475]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 8590801]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 9412475]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 9412475]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 9412475]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9742397]; GO_process: GO:0032465 - regulation of cytokinesis [Evidence IMP] [PMID 15941409]
AWJ20_1120	Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog, GSC2, that arose from the whole genome duplication; GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IEA]; GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IDA] [PMID 7983071]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11856368]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11856368]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8602515]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11856368]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8602515]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11856368]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IEA,IEA]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IDA,IMP] [PMID 7528927]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IDA] [PMID 7649185]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IEA]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 7528927]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0008360 - regulation of cell shape [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]
AWJ20_1121	Mitochondrial protein involved in mitochondrial protein sorting; putative membrane-spanning ATPase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 8226973]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8226973]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IGI] [PMID 8226973]
AWJ20_1122	Mitochondrial protein involved in mitochondrial protein sorting; putative membrane-spanning ATPase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 8226973]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8226973]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IGI] [PMID 8226973]
AWJ20_1124	Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid; GO_component: GO:0005946 - alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [Evidence IDA,IMP] [PMID 1425702]; GO_component: GO:0005946 - alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [Evidence IGI,IMP,IPI] [PMID 9837904]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0003825 - alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [Evidence IEA,IEA]; GO_function: GO:0003825 - alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [Evidence IDA,IMP] [PMID 1425702]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IDA,IMP] [PMID 1425702]; GO_process: GO:0034605 - cellular response to heat [Evidence IDA] [PMID 9660948]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11483159]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IDA,IMP] [PMID 1425702]
AWJ20_1125	Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p; GO_component: GO:0005950 - anthranilate synthase complex [Evidence IPI] [PMID 3881257]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IDA] [PMID 3881257]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IGI,ISS] [PMID 6323449]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016833 - oxo-acid-lyase activity [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 8432699]
AWJ20_1126	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 10580002]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IGI] [PMID 10747050]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP,IPI] [PMID 9528768]; GO_process: GO:0000173 - inactivation of MAPK activity involved in osmosensory signaling pathway [Evidence IGI] [PMID 11113180]; GO_process: GO:0000173 - inactivation of MAPK activity involved in osmosensory signaling pathway [Evidence IDA,IGI,IMP] [PMID 12477803]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 10580002]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 12477803]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IMP,IPI] [PMID 10580002]
AWJ20_1127	3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008296 - 3'-5'-exodeoxyribonuclease activity [Evidence IDA] [PMID 15657035]; GO_function: GO:0016888 - endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IDA] [PMID 15657035]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0006309 - apoptotic DNA fragmentation [Evidence IMP] [PMID 15657035]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15657035]
AWJ20_1128	Oxysterol-binding protein; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 20008566]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16096648]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20008566]; GO_function: GO:0008142 - oxysterol binding [Evidence ISS] [PMID 11238399]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 15173322]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17004323]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 16096648]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IGI] [PMID 17004323]; GO_process: GO:0016125 - sterol metabolic process [Evidence IGI] [PMID 16096648]; GO_process: GO:0015918 - sterol transport [Evidence IGI] [PMID 16585271]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1129	Nonessential hypothetical protein; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1130	top hit is XP_007844384.1 originated in Moniliophthora roreri MCA 2997
AWJ20_1131	hypothetical protein; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1132	UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003983 - UTP:glucose-1-phosphate uridylyltransferase activity [Evidence IEA]; GO_function: GO:0003983 - UTP:glucose-1-phosphate uridylyltransferase activity [Evidence IMP,ISS] [PMID 7588797]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0070569 - uridylyltransferase activity [Evidence IDA] [PMID 22580055]; GO_process: GO:0006078 - (1->6)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 17531808]; GO_process: GO:0006011 - UDP-glucose metabolic process [Evidence IMP] [PMID 7588797]; GO_process: GO:0006011 - UDP-glucose metabolic process [Evidence IGI,IMP] [PMID 9252577]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IGI,IMP] [PMID 9252577]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IGI] [PMID 9252577]
AWJ20_1134	Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; GO_component: GO:0005622 - intracellular [Evidence TAS] [PMID 7489497]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9759502]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA,IEA]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IDA] [PMID 7489497]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0006401 - RNA catabolic process [Evidence IDA] [PMID 7489497]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_1135	Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 17576801]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 17576801]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 17576801]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 14690591]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19075114]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0090002 - establishment of protein localization to plasma membrane [Evidence IDA] [PMID 19075114]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IDA,IMP] [PMID 17576801]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IDA] [PMID 17576801]; GO_process: GO:0019236 - response to pheromone [Evidence IDA] [PMID 17576801]
AWJ20_1136	top hit is XP_963644.2 originated in Neurospora crassa OR74A
AWJ20_1137	allele of CaO19.8194
AWJ20_1139	Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 8702468]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0001208 - histone H2A-H2B dimer displacement [Evidence IMP] [PMID 22199252]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IGI] [PMID 17023424]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 17023424]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 7957102]
AWJ20_1140	3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 7754706]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA,IMP,ISM] [PMID 8125978]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 19470242]; GO_function: GO:0003988 - acetyl-CoA C-acyltransferase activity [Evidence IEA]; GO_function: GO:0003988 - acetyl-CoA C-acyltransferase activity [Evidence IDA] [PMID 7754706]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1143	Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_1149	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 12499351]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15039776]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 15039776]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 9199164]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005771 - multivesicular body [Evidence IMP] [PMID 14523026]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15623581]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15707981]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 6759873]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 15707981]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 6759873]; GO_process: GO:0015846 - polyamine transport [Evidence IMP] [PMID 15707981]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_1151	N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 17908202]; GO_component: GO:0033101 - cellular bud membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence ISS] [PMID 10559922]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 10559922]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0009966 - regulation of signal transduction [Evidence IMP,IPI] [PMID 12477731]
AWJ20_1153	Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 16478783]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 16478783]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000145 - exocyst [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 1512289]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 7615633]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 16478783]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IDA] [PMID 10022848]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
AWJ20_1157	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]
AWJ20_1158	Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 11266460]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 9685359]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 9786948]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11266460]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 19812251]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 16624808]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IEA]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IMP,IPI] [PMID 12808034]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IMP] [PMID 9786948]; GO_process: GO:0051646 - mitochondrion localization [Evidence IGI] [PMID 23341591]
AWJ20_1160	Fungal Genetics Stock Center 12732; Fungal Genetics Stock Center 12731
AWJ20_1161	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IEA]; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 22343726]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 22343726]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1162	F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 9716410]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043224 - nuclear SCF ubiquitin ligase complex [Evidence IDA] [PMID 10637232]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10637232]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 15870262]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 15870262]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 9716410]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 9716410]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IGI,IPI] [PMID 9499404]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 15870262]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 15870262]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0046685 - response to arsenic-containing substance [Evidence IDA] [PMID 15689486]; GO_process: GO:0046686 - response to cadmium ion [Evidence IDA] [PMID 15689486]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1163	Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8909536]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA,IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IDA] [PMID 9990311]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IMP] [PMID 11839781]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IDA] [PMID 15772160]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IEA]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IMP] [PMID 22573892]
AWJ20_1164	Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 1944230]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IDA] [PMID 11546815]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence ISS] [PMID 10954195]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IEA]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006825 - copper ion transport [Evidence IGI,ISS] [PMID 8662933]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 2835635]; GO_process: GO:0008535 - respiratory chain complex IV assembly [Evidence IEA]; GO_process: GO:0051775 - response to redox state [Evidence ISS] [PMID 15659396]
AWJ20_1166	Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA,IGI] [PMID 22570489]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 22570489]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15611164]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP,IPI] [PMID 22570489]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 15611164]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IGI,IMP] [PMID 15611164]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IGI,IMP] [PMID 22570489]
AWJ20_1167	Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1169	Nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 19861225]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 7800479]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence TAS] [PMID 10690410]
AWJ20_1171	Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IC] [PMID 15590835]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 23194188]
AWJ20_1172	Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA,ISS] [PMID 16476776]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006813 - potassium ion transport [Evidence IGI] [PMID 20197279]; GO_process: GO:0051204 - protein insertion into mitochondrial membrane [Evidence IMP] [PMID 16476776]; GO_process: GO:0015992 - proton transport [Evidence IGI] [PMID 20197279]
AWJ20_1173	deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0035870 - dITP diphosphatase activity [Evidence IDA] [PMID 21548881]; GO_function: GO:0004170 - dUTP diphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004170 - dUTP diphosphatase activity [Evidence IDA,IMP] [PMID 21548881]; GO_function: GO:0004170 - dUTP diphosphatase activity [Evidence IMP] [PMID 8223452]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0035863 - dITP catabolic process [Evidence IDA] [PMID 21548881]; GO_process: GO:0006226 - dUMP biosynthetic process [Evidence IEA]; GO_process: GO:0046081 - dUTP catabolic process [Evidence IDA,IMP] [PMID 21548881]; GO_process: GO:0046080 - dUTP metabolic process [Evidence IEA]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA]; GO_process: GO:0009213 - pyrimidine deoxyribonucleoside triphosphate catabolic process [Evidence IMP] [PMID 8223452]
AWJ20_1174	Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15631992]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 16020778]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IMP] [PMID 15631992]; GO_process: GO:0007005 - mitochondrion organization [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 11907266]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 16020778]; GO_process: GO:1900208 - regulation of cardiolipin metabolic process [Evidence IGI] [PMID 22403410]
AWJ20_1175	Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IDA] [PMID 7493316]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 7493316]
AWJ20_1176	Protein required for normal mitochondrial morphology; mitochondrial inner membrane protein; may be involved in fission of the inner membrane; forms a homo-oligomeric complex; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12591915]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007007 - inner mitochondrial membrane organization [Evidence IGI,IMP] [PMID 12591915]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 11907266]
AWJ20_1177	ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 9584156]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9724628]
AWJ20_1179	hypothetical protein; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1180	Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004422 - hypoxanthine phosphoribosyltransferase activity [Evidence IGI] [PMID 10217799]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0000310 - xanthine phosphoribosyltransferase activity [Evidence IMP] [PMID 10217799]; GO_process: GO:0032265 - XMP salvage [Evidence IMP] [PMID 10217799]; GO_process: GO:0046100 - hypoxanthine metabolic process [Evidence IGI] [PMID 10217799]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]
AWJ20_1181	Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1182	Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; complex also includes Bur6p; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0017054 - negative cofactor 2 complex [Evidence IDA] [PMID 8948634]; GO_component: GO:0017054 - negative cofactor 2 complex [Evidence IPI] [PMID 9023340]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21976730]; GO_function: GO:0001132 - TBP-class protein binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 8948634]; GO_function: GO:0001132 - TBP-class protein binding RNA polymerase II transcription factor activity [Evidence IPI] [PMID 9096360]; GO_function: GO:0001129 - TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [Evidence IMP] [PMID 18048413]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 18703679]; GO_function: GO:0001047 - core promoter binding [Evidence IDA] [PMID 18703679]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IDA] [PMID 8948634]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IGI,IMP] [PMID 10713169]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IDA,IMP] [PMID 9023340]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 18048413]; GO_process: GO:1900446 - negative regulation of tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 9023340]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 10713169]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8948634]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 9023340]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9096360]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8948634]; GO_process: GO:0061408 - positive regulation of transcription from RNA polymerase II promoter in response to heat stress [Evidence IMP] [PMID 18048413]; GO_process: GO:0045898 - regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 21976730]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1183	Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9852143]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852143]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 9755161]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 9852143]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,ISS] [PMID 9755161]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1184	Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9852143]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852143]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 9755161]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 9852143]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,ISS] [PMID 9755161]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1185	Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence TAS] [PMID 11356840]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004584 - dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity [Evidence IMP] [PMID 11356840]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 11356840]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 2005867]
AWJ20_1186	Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004400 - histidinol-phosphate transaminase activity [Evidence IEA,IEA]; GO_function: GO:0004400 - histidinol-phosphate transaminase activity [Evidence IMP] [PMID 14190241]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1189	RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; the Rpb4p/Rpb7p subcomplex regulates cellular lifespan via an mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17056745]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 17875743]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17056745]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA,IMP] [PMID 11087726]; GO_function: GO:0003727 - single-stranded RNA binding [Evidence IDA,IMP] [PMID 11087726]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IPI] [PMID 21074047]; GO_process: GO:0000291 - nuclear-transcribed mRNA catabolic process, exonucleolytic [Evidence IGI] [PMID 17875743]; GO_process: GO:0060213 - positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IMP] [PMID 17875743]; GO_process: GO:0045948 - positive regulation of translational initiation [Evidence IMP] [PMID 21074047]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI] [PMID 10082533]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 11087726]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1193	hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016872 - intramolecular lyase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1194	Nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p; essential gene; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP,IPI] [PMID 11728313]
AWJ20_1197	AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12808025]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA,IMP] [PMID 12808025]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IMP] [PMID 15634331]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8241279]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IMP,IPI] [PMID 15634331]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16007078]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16911527]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0016562 - protein import into peroxisome matrix, receptor recycling [Evidence IDA,IGI,IMP] [PMID 16007078]; GO_process: GO:0001302 - replicative cell aging [Evidence IGI] [PMID 17465979]
AWJ20_1200	Acidic protein of the mitochondrial matrix; involved in oxidative phosphorylation; related to the human complement receptor gC1q-R; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 9305894]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9305894]
AWJ20_1203	RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22362748]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 22362748]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 22362748]; GO_process: GO:1900008 - negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging [Evidence IMP] [PMID 22362748]; GO_process: GO:0001185 - termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript [Evidence IDA,IMP] [PMID 22805593]
AWJ20_1205	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; N-terminally propionylated in vivo; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 8070651]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1206	RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23222640]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15351640]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0010834 - telomere maintenance via telomere shortening [Evidence IGI] [PMID 11739741]
AWJ20_1208	Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004151 - dihydroorotase activity [Evidence IEA,IEA]; GO_function: GO:0004151 - dihydroorotase activity [Evidence IMP,ISS] [PMID 2897615]; GO_function: GO:0004151 - dihydroorotase activity [Evidence IMP] [PMID 4550660]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0044205 - 'de novo' UMP biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0019856 - pyrimidine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IMP] [PMID 2897615]
AWJ20_1214	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17897954]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IDA,ISS] [PMID 8454584]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0018548 - pentaerythritol trinitrate reductase activity [Evidence IEA]; GO_function: GO:0052690 - trichloro-p-hydroquinone reductive dehalogenase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17897954]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1215	Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11029046]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 18497817]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11029046]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17499717]
AWJ20_1216	Protein required for nuclear migration; component of the mitochondria-ER-cortex-ancor (MECA); required for the association of mitochondria with the cell cortex and for accurate distribution of mitochondrial network; interacts with Mdm36p to link the ER and motochondria at the cortex; localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 11121446]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11121446]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005543 - phospholipid binding [Evidence IEA]; GO_function: GO:0015631 - tubulin binding [Evidence IPI] [PMID 11266443]; GO_process: GO:0032065 - cortical protein anchoring [Evidence IEA]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IMP] [PMID 11121446]; GO_process: GO:0000266 - mitochondrial fission [Evidence IMP] [PMID 17336903]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI] [PMID 17336903]; GO_process: GO:0051646 - mitochondrion localization [Evidence IGI,IMP,IPI] [PMID 23341591]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 11121446]
AWJ20_1218	Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA,ISS] [PMID 12514182]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 15342786]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 15342786]
AWJ20_1219	Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER); GO_component: GO:0043625 - delta DNA polymerase complex [Evidence IBA]; GO_component: GO:0043625 - delta DNA polymerase complex [Evidence TAS] [PMID 9745046]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005657 - replication fork [Evidence IDA] [PMID 15773893]; GO_function: GO:0008296 - 3'-5'-exodeoxyribonuclease activity [Evidence IBA]; GO_function: GO:0008296 - 3'-5'-exodeoxyribonuclease activity [Evidence IMP] [PMID 1648480]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA,IMP] [PMID 1678279]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 18635534]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 1678279]; GO_process: GO:0045004 - DNA replication proofreading [Evidence IBA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IDA] [PMID 16837458]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IDA] [PMID 17429354]; GO_process: GO:0006287 - base-excision repair, gap-filling [Evidence IBA]; GO_process: GO:0045005 - maintenance of fidelity involved in DNA-dependent DNA replication [Evidence IGI] [PMID 15601866]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006297 - nucleotide-excision repair, DNA gap filling [Evidence IBA]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IBA]
AWJ20_1222	Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; involved in localization of actin and chitin; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; GO_component: GO:0000938 - GARP complex [Evidence IPI] [PMID 10637310]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10637310]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12377769]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 10637310]; GO_process: GO:0030029 - actin filament-based process [Evidence IGI] [PMID 9153752]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IDA] [PMID 12686613]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1225	Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases; GO_component: GO:0032865 - ERMES complex [Evidence IPI] [PMID 21825164]; GO_component: GO:0032865 - ERMES complex [Evidence IPI] [PMID 21945531]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 15479738]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 15479738]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 21036903]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0019725 - cellular homeostasis [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IMP] [PMID 18245340]; GO_process: GO:0055091 - phospholipid homeostasis [Evidence IGI] [PMID 21825164]; GO_process: GO:0010821 - regulation of mitochondrion organization [Evidence IMP] [PMID 21825164]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_1226	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 21536748]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8816439]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 11134339]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21536748]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8816439]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IGI,IMP] [PMID 18762578]; GO_process: GO:0007569 - cell aging [Evidence IMP] [PMID 10662670]; GO_process: GO:0006342 - chromatin silencing [Evidence IMP] [PMID 10662670]; GO_process: GO:0000078 - cytokinesis after mitosis checkpoint [Evidence IGI] [PMID 20980617]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI,IMP] [PMID 8816439]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI,IMP,IPI] [PMID 15619606]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 21536748]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 18762578]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1227	tRNA methyltransferase; methylates the N-1 position of guanine at position 9 in tRNAs; protein abundance increases in response to DNA replication stress; member of the SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer originates from the TRM10 locus; genetic analysis shows the 18-mer is the translation regulator; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0052905 - tRNA (guanine(9)-N(1))-methyltransferase activity [Evidence IEA]; GO_function: GO:0016423 - tRNA (guanine) methyltransferase activity [Evidence IDA] [PMID 12702816]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 12702816]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_1228	Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 14697254]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 14697254]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_1229	Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10681558]; GO_component: GO:0005634 - nucleus [Evidence IDA,ISS] [PMID 2408019]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP,ISS] [PMID 10681558]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 10681558]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1230	Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11489916]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19446323]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IDA,IGI,IMP] [PMID 19446322]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446323]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence ISS] [PMID 10419517]
AWJ20_1231	Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_1232	Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IDA] [PMID 7925282]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IPI] [PMID 7925282]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence IC] [PMID 7925282]; GO_process: GO:0045047 - protein targeting to ER [Evidence IPI] [PMID 7925282]
AWJ20_1233	3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9933355]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence ISS] [PMID 9396823]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IMP] [PMID 10716935]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 10716935]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI] [PMID 10716935]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 10716935]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI,IMP] [PMID 9933355]
AWJ20_1235	Integral peroxisomal membrane protein; required for translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8858166]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8858167]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 10087260]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 12595255]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IEA]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IGI,IPI] [PMID 10087260]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 12595255]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 15798189]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1237	Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 10779349]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 12756538]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IPI] [PMID 10779349]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IEA,IEA]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IDA] [PMID 15485855]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IMP] [PMID 7753023]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IDA] [PMID 8395015]; GO_function: GO:0004435 - phosphatidylinositol phospholipase C activity [Evidence IMP] [PMID 9784626]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_process: GO:0032958 - inositol phosphate biosynthetic process [Evidence IMP] [PMID 10390371]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IMP] [PMID 7753023]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IDA] [PMID 8395015]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IMP] [PMID 19205744]; GO_process: GO:0007165 - signal transduction [Evidence IEA,IEA]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IGI,IPI] [PMID 10514491]
AWJ20_1238	Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9034325]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 16738661]; GO_function: GO:0030515 - snoRNA binding [Evidence IDA] [PMID 12527778]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0006364 - rRNA processing [Evidence IMP,IPI] [PMID 12527778]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1239	Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16365162]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1666302]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1865879]; GO_function: GO:0005087 - Ran guanyl-nucleotide exchange factor activity [Evidence IGI] [PMID 1865879]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP] [PMID 2548085]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 11739405]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IEA]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP] [PMID 11739405]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1240	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 20936498]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IMP,IPI] [PMID 8187177]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 8187177]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP,IPI] [PMID 8187177]
AWJ20_1241	Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IGI,ISA] [PMID 8636229]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IGI] [PMID 8662642]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IGI] [PMID 8636229]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1242	Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p; GO_component: GO:0005684 - U2-type spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 14690591]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 19935684]
AWJ20_1245	Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11116400]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IDA] [PMID 11932453]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 11116400]
AWJ20_1246	top hit is XP_002974472.1 originated in Selaginella moellendorffii
AWJ20_1248	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; TEF2-RFP levels increase during replicative aging; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20032305]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005853 - eukaryotic translation elongation factor 1 complex [Evidence ISS] [PMID 3026912]; GO_function: GO:0019003 - GDP binding [Evidence IDA] [PMID 17925388]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 17925388]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IMP] [PMID 10514524]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP] [PMID 10766739]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP] [PMID 17203074]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]; GO_process: GO:0006414 - translational elongation [Evidence IMP] [PMID 10514524]
AWJ20_1249	Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_1252	Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1253	NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0032440 - 2-alkenal reductase [NAD(P)] activity [Evidence IDA] [PMID 21276778]; GO_function: GO:0017091 - AU-rich element binding [Evidence IDA] [PMID 17497241]; GO_function: GO:0017091 - AU-rich element binding [Evidence IDA] [PMID 19007762]; GO_function: GO:0003960 - NADPH:quinone reductase activity [Evidence IEA]; GO_function: GO:0003960 - NADPH:quinone reductase activity [Evidence IDA] [PMID 17497241]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17497241]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1254	Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20385783]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17616518]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20385783]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IMP] [PMID 17616518]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0000432 - positive regulation of transcription from RNA polymerase II promoter by glucose [Evidence IMP] [PMID 17616518]
AWJ20_1255	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15044472]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 15044472]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 15654430]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 15044472]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 15044472]; GO_function: GO:0045142 - triplex DNA binding [Evidence IDA] [PMID 18029617]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 16580682]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IDA] [PMID 11514626]; GO_process: GO:0043558 - regulation of translational initiation in response to stress [Evidence IMP] [PMID 16580682]; GO_process: GO:0000723 - telomere maintenance [Evidence IGI] [PMID 12207228]; GO_process: GO:0006414 - translational elongation [Evidence IGI,IMP] [PMID 19666721]
AWJ20_1256	Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 8841414]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8841414]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0050203 - oxalate-CoA ligase activity [Evidence IDA,IMP] [PMID 24291261]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0033611 - oxalate catabolic process [Evidence IDA,IMP] [PMID 24291261]
AWJ20_1257	Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IDA] [PMID 9528754]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9528754]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 9528754]; GO_process: GO:0070124 - mitochondrial translational initiation [Evidence IGI] [PMID 9528754]
AWJ20_1258	Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0032549 - ribonucleoside binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IGI] [PMID 2199311]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1259	Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IGI,ISS] [PMID 11454748]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IEA]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 16735580]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IGI,ISS] [PMID 11454748]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 11454748]
AWJ20_1261	N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8183942]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA,IMP] [PMID 8183942]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_1262	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IDA] [PMID 9620854]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IPI] [PMID 17881380]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IDA] [PMID 9620854]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 23700311]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000171 - ribonuclease MRP activity [Evidence IMP] [PMID 16618965]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IEA,IEA]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IMP] [PMID 16618965]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0034965 - intronic box C/D snoRNA processing [Evidence IDA] [PMID 18713869]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 14729943]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 7926742]; GO_process: GO:0001682 - tRNA 5'-leader removal [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 7926742]
AWJ20_1264	Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IMP,ISS] [PMID 8692962]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0052926 - dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0052918 - dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0004376 - glycolipid mannosyltransferase activity [Evidence IMP] [PMID 15987956]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IMP,ISS] [PMID 8692962]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0006488 - dolichol-linked oligosaccharide biosynthetic process [Evidence IMP] [PMID 15987956]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 8692962]
AWJ20_1265	Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 8706758]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0004019 - adenylosuccinate synthase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004019 - adenylosuccinate synthase activity [Evidence IDA] [PMID 10417315]; GO_function: GO:0004019 - adenylosuccinate synthase activity [Evidence IMP] [PMID 5807803]; GO_function: GO:0004019 - adenylosuccinate synthase activity [Evidence IDA] [PMID 8706758]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0044208 - 'de novo' AMP biosynthetic process [Evidence IEA]; GO_process: GO:0006167 - AMP biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 5807803]
AWJ20_1266	Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004035 - alkaline phosphatase activity [Evidence IDA] [PMID 9561742]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA] [PMID 9561742]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 9561742]
AWJ20_1267	Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; PRB1 has a paralog, YSP3, that arose from the whole genome duplication; GO_component: GO:0005619 - ascospore wall [Evidence IBA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence TAS] [PMID 2674123]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence TAS] [PMID 9529893]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042802 - identical protein binding [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence ISA] [PMID 3325823]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 377296]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 385314]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 2674123]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IBA,IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 2674123]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 2674123]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 385314]
AWJ20_1268	Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17034789]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17034789]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IDA] [PMID 19342587]; GO_function: GO:0004061 - arylformamidase activity [Evidence IDA] [PMID 18205391]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016212 - kynurenine-oxoglutarate transaminase activity [Evidence IEA]; GO_function: GO:0016212 - kynurenine-oxoglutarate transaminase activity [Evidence IDA,ISS] [PMID 18205391]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0097053 - L-kynurenine catabolic process [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0034276 - kynurenic acid biosynthetic process [Evidence IDA,ISS] [PMID 18205391]
AWJ20_1271	Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16769905]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA,IPI] [PMID 16769905]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0070181 - small ribosomal subunit rRNA binding [Evidence IDA,IMP] [PMID 24152547]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1275	Vacuolar glutathione S-conjugate transporter; member of ATP-binding cassette family; ATPase activity required to support vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; has role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23658021]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8692889]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0015127 - bilirubin transmembrane transporter activity [Evidence IGI,IMP] [PMID 10790694]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 10220408]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12383937]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12755704]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 9217966]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015723 - bilirubin transport [Evidence IGI,IMP] [PMID 10790694]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046686 - response to cadmium ion [Evidence IEA]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 10220408]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 12755704]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 9217966]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 10790694]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 23658021]
AWJ20_1276	Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10672016]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IEA]; GO_function: GO:0034736 - cholesterol O-acyltransferase activity [Evidence IEA]; GO_function: GO:0034737 - ergosterol O-acyltransferase activity [Evidence IGI,IMP] [PMID 10672016]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0008204 - ergosterol metabolic process [Evidence IGI,IMP] [PMID 10672016]
AWJ20_1277	Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 17135290]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 17135288]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0034982 - mitochondrial protein processing [Evidence IMP] [PMID 17135288]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP] [PMID 17135288]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 17135290]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_1280	Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 18442968]; GO_component: GO:0005761 - mitochondrial ribosome [Evidence IDA] [PMID 18442968]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 16415861]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 8553703]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 18442968]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA,IEA]; GO_process: GO:0045727 - positive regulation of translation [Evidence IEA]; GO_process: GO:0045727 - positive regulation of translation [Evidence IMP] [PMID 18442968]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1281	JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNAP II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; target of stess-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10523651]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001078 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [Evidence IDA,IMP] [PMID 10523651]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IDA,IMP] [PMID 17369256]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IDA,IMP] [PMID 17371840]; GO_function: GO:0032454 - histone demethylase activity (H3-K9 specific) [Evidence IDA] [PMID 17371840]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IMP] [PMID 21296759]; GO_process: GO:0016577 - histone demethylation [Evidence IDA,IMP] [PMID 17369256]; GO_process: GO:0016577 - histone demethylation [Evidence IDA,IMP] [PMID 17371840]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 10523651]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1282	S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004013 - adenosylhomocysteinase activity [Evidence IEA,IEA]; GO_function: GO:0004013 - adenosylhomocysteinase activity [Evidence ISA] [PMID 15556636]; GO_function: GO:0004013 - adenosylhomocysteinase activity [Evidence IMP] [PMID 18591246]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0019510 - S-adenosylhomocysteine catabolic process [Evidence ISA] [PMID 15556636]; GO_process: GO:0019510 - S-adenosylhomocysteine catabolic process [Evidence IMP] [PMID 18591246]; GO_process: GO:0006555 - methionine metabolic process [Evidence NAS] [PMID 11752249]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA,IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 18591246]; GO_process: GO:0006641 - triglyceride metabolic process [Evidence IMP] [PMID 18591246]
AWJ20_1283	Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 8168133]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15383543]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 9973563]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 8943361]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 8168133]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 7957078]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 10567545]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IMP] [PMID 8168133]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9973563]; GO_process: GO:0009408 - response to heat [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 8603724]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_1290	top hit is XP_002839470.1 originated in Tuber melanosporum Mel28; conserved fungal protein
AWJ20_1292	Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 18367543]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043328 - protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IGI] [PMID 18367543]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1294	Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0050278 - sedoheptulose-bisphosphatase activity [Evidence IEA]; GO_function: GO:0050278 - sedoheptulose-bisphosphatase activity [Evidence IDA,IMP] [PMID 21663798]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0046390 - ribose phosphate biosynthetic process [Evidence IDA,IMP] [PMID 21663798]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1296	Hsp90 cochaperone; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 12525481]; GO_function: GO:0042030 - ATPase inhibitor activity [Evidence IDA] [PMID 21170051]; GO_function: GO:0030544 - Hsp70 protein binding [Evidence IDA] [PMID 12716905]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 12525481]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 9927435]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_process: GO:0006457 - protein folding [Evidence IGI,IMP] [PMID 8972212]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_1297	Phosphatidylinositol 3,5-bisphosphate-binding protein; plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15103325]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 18769150]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 18769150]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 15155809]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IBA]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IBA]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 15103325]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18769150]; GO_process: GO:0042594 - response to starvation [Evidence IBA]
AWJ20_1301	RNA helicase in the DEAD-box family; involved in RNA isomerization at the 5' splice site; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence TAS] [PMID 9476892]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence TAS] [PMID 9476892]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000354 - cis assembly of pre-catalytic spliceosome [Evidence TAS] [PMID 9476892]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_1303	Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 11713271]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IC] [PMID 11713271]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,IGI,IMP,IPI] [PMID 11713271]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA,IGI,IMP,IPI] [PMID 11713271]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_1304	eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0002188 - translation reinitiation [Evidence IMP] [PMID 20679478]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]
AWJ20_1305	Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008934 - inositol monophosphate 1-phosphatase activity [Evidence IEA]; GO_function: GO:0008934 - inositol monophosphate 1-phosphatase activity [Evidence IDA,ISA] [PMID 10096091]; GO_function: GO:0008934 - inositol monophosphate 1-phosphatase activity [Evidence IGI,IMP] [PMID 12593845]; GO_function: GO:0052832 - inositol monophosphate 3-phosphatase activity [Evidence IEA]; GO_function: GO:0052833 - inositol monophosphate 4-phosphatase activity [Evidence IEA]; GO_function: GO:0052834 - inositol monophosphate phosphatase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006021 - inositol biosynthetic process [Evidence IEA]; GO_process: GO:0046855 - inositol phosphate dephosphorylation [Evidence IDA] [PMID 10096091]; GO_process: GO:0046855 - inositol phosphate dephosphorylation [Evidence IGI,IMP] [PMID 12593845]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]
AWJ20_1307	Component of serine palmitoyltransferase; responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0017059 - serine C-palmitoyltransferase complex [Evidence IMP] [PMID 1556076]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IEA]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IMP] [PMID 1556076]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IGI] [PMID 8058731]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 1556076]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]
AWJ20_1308	Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10671482]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 10671482]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 10671482]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP] [PMID 10671482]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 10671482]
AWJ20_1310	5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 3023841]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IMP] [PMID 24173275]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IMP] [PMID 323256]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IDA] [PMID 6381051]; GO_function: GO:0003870 - 5-aminolevulinate synthase activity [Evidence IMP] [PMID 7035824]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 323256]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]; GO_process: GO:0033014 - tetrapyrrole biosynthetic process [Evidence IEA]
AWJ20_1313	Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15044461]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IEA,IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IDA] [PMID 15044461]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0034638 - phosphatidylcholine catabolic process [Evidence IMP] [PMID 15044461]; GO_process: GO:0046470 - phosphatidylcholine metabolic process [Evidence IEA]; GO_process: GO:0071071 - regulation of phospholipid biosynthetic process [Evidence IMP] [PMID 19841481]
AWJ20_1314	Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 20404317]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 3060376]; GO_component: GO:0005761 - mitochondrial ribosome [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 20404317]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 3060376]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 20404317]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 7828914]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1315	Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificity), and Som1p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0042720 - mitochondrial inner membrane peptidase complex [Evidence IPI] [PMID 8132591]; GO_component: GO:0042720 - mitochondrial inner membrane peptidase complex [Evidence IPI] [PMID 8266095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0004175 - endopeptidase activity [Evidence IDA] [PMID 8132591]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 8266095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0006627 - protein processing involved in protein targeting to mitochondrion [Evidence IMP] [PMID 8266095]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_1316	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 10508172]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_1318	Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_1319	ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16260602]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042624 - ATPase activity, uncoupled [Evidence IMP] [PMID 16260602]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 16260602]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 16260602]
AWJ20_1320	2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008173 - RNA methyltransferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016423 - tRNA (guanine) methyltransferase activity [Evidence IDA] [PMID 9917067]; GO_function: GO:0009020 - tRNA (guanosine-2'-O-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 9917067]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_1321	Kinesin-related antiparallel sliding motor protein involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; also inhibits spindle elongation and promotes spindle disassembly in late anaphase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 9693366]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IDA] [PMID 9693366]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906145]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906148]; GO_function: GO:0070463 - tubulin-dependent ATPase activity [Evidence IDA] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IMP] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 23851487]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 9813090]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IGI,IMP] [PMID 10525539]; GO_process: GO:0031115 - negative regulation of microtubule polymerization [Evidence IMP] [PMID 24616221]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 9693366]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906145]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906148]; GO_process: GO:0032888 - regulation of mitotic spindle elongation [Evidence IMP] [PMID 24616221]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 23851487]
AWJ20_1322	Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18664566]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IEA,IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 19145231]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IEA,IEA]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 18664566]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19145231]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19151091]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IEA,IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 17592039]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_1324	Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IMP] [PMID 11238938]; GO_function: GO:0030674 - protein binding, bridging [Evidence IGI,IMP] [PMID 21282348]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 7736590]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_1325	Guanylyltransferase involved in mRNA 5' capping; subunit of the mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5?-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; GO_component: GO:0031533 - mRNA cap methyltransferase complex [Evidence IEA]; GO_component: GO:0031533 - mRNA cap methyltransferase complex [Evidence IGI,IPI] [PMID 9710603]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 9832501]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0004484 - mRNA guanylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004484 - mRNA guanylyltransferase activity [Evidence IMP] [PMID 8718687]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IEA,IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IMP] [PMID 8718687]; GO_process: GO:0006397 - mRNA processing [Evidence IEA,IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 15226422]
AWJ20_1326	Mitochondrial ribosomal protein of the small subunit; has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]
AWJ20_1327	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10903515]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015244 - fluconazole transporter activity [Evidence ISS] [PMID 9235926]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI,IMP] [PMID 10572257]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI] [PMID 9235926]; GO_process: GO:0015893 - drug transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9235926]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1328	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10903515]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015244 - fluconazole transporter activity [Evidence ISS] [PMID 9235926]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI,IMP] [PMID 10572257]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI] [PMID 9235926]; GO_process: GO:0015893 - drug transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9235926]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1329	Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0016298 - lipase activity [Evidence NAS] [PMID 10341423]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 10341423]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
AWJ20_1331	Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1332	Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly; GO_component: GO:0031416 - NatB complex [Evidence IDA] [PMID 12783868]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IMP] [PMID 12783868]; GO_process: GO:0017196 - N-terminal peptidyl-methionine acetylation [Evidence IGI,IMP] [PMID 12783868]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IMP] [PMID 9105043]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IMP] [PMID 9105043]
AWJ20_1333	Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 11864607]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0008097 - 5S rRNA binding [Evidence IPI] [PMID 11864606]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IPI] [PMID 11864606]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 11864607]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1335	Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990070 - TRAPPI protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 17110339]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10727015]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_1336	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress; GO_component: GO:0031415 - NatA complex [Evidence IDA] [PMID 14517307]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 14517307]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IDA,IMP] [PMID 2551674]; GO_function: GO:0061607 - peptide alpha-N-propionyltransferase activity [Evidence IMP] [PMID 23043182]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006474 - N-terminal protein amino acid acetylation [Evidence IDA,IMP] [PMID 2551674]; GO_process: GO:0061606 - N-terminal protein amino acid propionylation [Evidence IMP] [PMID 23043182]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 17652096]
AWJ20_1337	Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019781 - NEDD8 activating enzyme activity [Evidence IDA,ISS] [PMID 9545234]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008641 - small protein activating enzyme activity [Evidence IEA]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0045116 - protein neddylation [Evidence IEA]; GO_process: GO:0045116 - protein neddylation [Evidence IDA,IMP,ISS] [PMID 9545234]
AWJ20_1341	Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation; GO_component: GO:0005671 - Ada2/Gcn5/Ada3 transcription activator complex [Evidence IPI] [PMID 10490601]; GO_component: GO:0005671 - Ada2/Gcn5/Ada3 transcription activator complex [Evidence IDA] [PMID 7862114]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9224714]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 18039853]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0010484 - H3 histone acetyltransferase activity [Evidence IDA,IGI,IMP] [PMID 18458063]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 8601308]; GO_function: GO:0070577 - lysine-acetylated histone binding [Evidence IDA] [PMID 20126658]; GO_function: GO:0003713 - transcription coactivator activity [Evidence TAS] [PMID 15075257]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IGI,IMP] [PMID 18458063]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 9042963]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 19822662]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 11867538]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1342	Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_1343	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000928 - gamma-tubulin small complex, spindle pole body [Evidence IPI] [PMID 9384578]; GO_component: GO:0005822 - inner plaque of spindle pole body [Evidence IDA] [PMID 9215630]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005815 - microtubule organizing center [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005824 - outer plaque of spindle pole body [Evidence IDA] [PMID 9215630]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 22842922]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9215630]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IEA]; GO_process: GO:0007020 - microtubule nucleation [Evidence TAS] [PMID 9153752]
AWJ20_1345	Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein; GO_component: GO:0031389 - Rad17 RFC-like complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10660302]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 12604797]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 9564050]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 11267834]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10511543]
AWJ20_1346	Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; with Grx4p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36; GRX3 has a paralog, GRX4, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18281282]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15456753]; GO_component: GO:0005634 - nucleus [Evidence IGI,IPI] [PMID 17074835]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IPI] [PMID 23045394]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IGI,IMP,ISS] [PMID 10567543]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 20889785]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IGI,IPI] [PMID 17074835]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI,IMP] [PMID 10567543]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17074835]; GO_process: GO:2000678 - negative regulation of transcription regulatory region DNA binding [Evidence IMP] [PMID 23045394]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_1349	Smaller subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0017087 - mitochondrial processing peptidase complex [Evidence IDA] [PMID 2905264]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 2905264]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006627 - protein processing involved in protein targeting to mitochondrion [Evidence IDA] [PMID 2007593]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_1350	Mitochondrial inner membrane hypothetical protein; similar to Tim18p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; SHH4 has a paralog, SDH4, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10637294]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]
AWJ20_1353	Zinc finger transcription factor involved in arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster domain type; involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3311884]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IDA] [PMID 10688655]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0000821 - regulation of arginine metabolic process [Evidence IMP] [PMID 10688655]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1357	High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1359	Vacuolar integral membrane protein required for efflux of amino acids; required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation; GO_component: GO:0071627 - integral component of fungal-type vacuolar membrane [Evidence IDA] [PMID 17021250]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032974 - amino acid transmembrane export from vacuole [Evidence IMP] [PMID 17021250]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1360	Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23222640]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 10564276]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 10564276]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IPI] [PMID 10564276]
AWJ20_1361	UDP-glucose-4-epimerase; catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 14764091]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IEA,IEA]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IMP] [PMID 14158615]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IDA] [PMID 14764091]; GO_function: GO:0004034 - aldose 1-epimerase activity [Evidence IEA]; GO_function: GO:0004034 - aldose 1-epimerase activity [Evidence IDA] [PMID 14764091]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IMP] [PMID 14158615]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IDA] [PMID 14764091]; GO_process: GO:0006012 - galactose metabolic process [Evidence IEA,IEA,IEA]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1363	Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15710404]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 9614122]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0034707 - chloride channel complex [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17662057]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15710404]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17662057]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17662057]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0005254 - chloride channel activity [Evidence IEA]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IDA] [PMID 12074596]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9614122]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:1902476 - chloride transmembrane transport [Evidence IEA]; GO_process: GO:0006821 - chloride transport [Evidence IEA,IEA]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0044070 - regulation of anion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1364	Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA,IPI] [PMID 12501245]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10817999]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9844639]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0051090 - regulation of sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1366	RNA helicase in the DEAD-box family; necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 8969184]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000348 - mRNA branch site recognition [Evidence TAS] [PMID 9476892]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_1367	Aminophospholipid translocase (flippase); localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase; DNF1 has a paralog, DNF2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12221123]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12631737]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence ISS] [PMID 9224683]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI] [PMID 12631737]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI,IMP] [PMID 12631737]; GO_process: GO:0007163 - establishment or maintenance of cell polarity [Evidence IGI] [PMID 15461661]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI] [PMID 12631737]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI,IMP] [PMID 17015438]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1370	Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 10075735]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 8083240]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 8083240]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 8083240]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8083240]; GO_function: GO:0003682 - chromatin binding [Evidence IMP] [PMID 10075735]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9159120]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10075735]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9312054]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10075735]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 10075735]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 8538771]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 9335335]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 9990508]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16980387]
AWJ20_1372	ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 11007476]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19061897]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070417 - cellular response to cold [Evidence IMP] [PMID 11855848]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 11063674]; GO_process: GO:0048255 - mRNA stabilization [Evidence IMP] [PMID 15220333]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11557770]; GO_process: GO:0061399 - positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion [Evidence IMP] [PMID 11509659]; GO_process: GO:0061419 - positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [Evidence IMP] [PMID 11509659]; GO_process: GO:0036083 - positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 9927444]
AWJ20_1373	ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 11007476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11007476]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_process: GO:0070417 - cellular response to cold [Evidence IGI] [PMID 11855848]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 11063674]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11557770]; GO_process: GO:0036083 - positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 9927444]
AWJ20_1377	Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 10521541]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000033 - alpha-1,3-mannosyltransferase activity [Evidence IGI,IMP] [PMID 10521541]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IGI,IMP] [PMID 10521541]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
AWJ20_1379	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1382	GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 12189143]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IGI,IPI,ISS] [PMID 12189143]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 12189143]
AWJ20_1386	Beta subunit of heterooctameric phosphofructokinase; involved in glycolysis; indispensable for anaerobic growth; activated by fructose-2,6-bisphosphate and AMP; mutation inhibits glucose induction of cell cycle-related genes; GO_component: GO:0005945 - 6-phosphofructokinase complex [Evidence IEA]; GO_component: GO:0005945 - 6-phosphofructokinase complex [Evidence IMP] [PMID 3007939]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_function: GO:0003872 - 6-phosphofructokinase activity [Evidence IEA,IEA]; GO_function: GO:0003872 - 6-phosphofructokinase activity [Evidence IMP] [PMID 3007939]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0006002 - fructose 6-phosphate metabolic process [Evidence IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IDA] [PMID 3000145]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 3007939]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IGI] [PMID 18632794]
AWJ20_1387	Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004586 - ornithine decarboxylase activity [Evidence IEA]; GO_function: GO:0004586 - ornithine decarboxylase activity [Evidence IDA] [PMID 2681188]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006596 - polyamine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009446 - putrescine biosynthetic process [Evidence IMP] [PMID 7929015]; GO_process: GO:0033387 - putrescine biosynthetic process from ornithine [Evidence IEA]
AWJ20_1398	Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004077 - biotin-[acetyl-CoA-carboxylase] ligase activity [Evidence IEA,IEA]; GO_function: GO:0004077 - biotin-[acetyl-CoA-carboxylase] ligase activity [Evidence IMP] [PMID 6108218]; GO_function: GO:0004078 - biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity [Evidence IEA]; GO_function: GO:0004079 - biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity [Evidence IEA]; GO_function: GO:0004080 - biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity [Evidence IEA]; GO_function: GO:0071734 - biotin-[pyruvate-carboxylase] ligase activity [Evidence IDA] [PMID 10551847]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009305 - protein biotinylation [Evidence IDA] [PMID 10551847]; GO_process: GO:0009305 - protein biotinylation [Evidence IMP] [PMID 6108218]
AWJ20_1400	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11854418]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IGI] [PMID 11864994]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 11854418]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA,IEA]; GO_process: GO:0043007 - maintenance of rDNA [Evidence IMP] [PMID 17203076]; GO_process: GO:0010032 - meiotic chromosome condensation [Evidence IMP] [PMID 14662740]; GO_process: GO:0051307 - meiotic chromosome separation [Evidence IMP] [PMID 14662740]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IPI] [PMID 10811823]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 11854418]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 11864994]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA,IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 11854418]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 11864994]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IMP] [PMID 14662740]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
AWJ20_1401	Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 16738307]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16738307]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 16738307]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IGI] [PMID 16738307]; GO_process: GO:0022618 - ribonucleoprotein complex assembly [Evidence IMP] [PMID 16738307]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IGI] [PMID 9707445]
AWJ20_1408	Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1409	Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12464632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA,IMP] [PMID 12464633]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA] [PMID 20385087]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IPI] [PMID 12464633]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IMP,IPI] [PMID 20385087]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 12464633]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17314407]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1410	Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15713625]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15632184]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004771 - sterol esterase activity [Evidence IEA]; GO_function: GO:0004771 - sterol esterase activity [Evidence IDA,IMP] [PMID 15632184]; GO_function: GO:0004771 - sterol esterase activity [Evidence IDA] [PMID 15713625]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 14587103]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 15632184]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 15713625]
AWJ20_1411	Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004020 - adenylylsulfate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004020 - adenylylsulfate kinase activity [Evidence IMP] [PMID 197388]; GO_function: GO:0004020 - adenylylsulfate kinase activity [Evidence IDA] [PMID 3019265]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IEA]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IMP] [PMID 197388]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IMP] [PMID 1101032]
AWJ20_1412	Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis; GO_component: GO:0000815 - ESCRT III complex [Evidence IDA] [PMID 12194857]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12194857]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IPI] [PMID 12194857]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
AWJ20_1414	Vacuolar membrane hypothetical protein; involved in vacuolar protein sorting; also detected in the mitochondria; GO_component: GO:0034424 - Vps55/Vps68 complex [Evidence IDA,IPI] [PMID 18216282]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP] [PMID 18216282]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1415	one of two likely peroxisomal copper amine oxidase genes; similar to A.niger AO-I; allele of CaO19.10662
AWJ20_1418	Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 3537704]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1420	Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10757808]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10757808]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA,IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IGI,IMP] [PMID 18694928]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IDA] [PMID 23919454]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006037 - cell wall chitin metabolic process [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0071555 - cell wall organization [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1421	Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 19525420]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004366 - glycerol-3-phosphate O-acyltransferase activity [Evidence IEA]; GO_function: GO:0004366 - glycerol-3-phosphate O-acyltransferase activity [Evidence IDA,IGI,IMP] [PMID 11544256]; GO_function: GO:0016287 - glycerone-phosphate O-acyltransferase activity [Evidence IEA]; GO_function: GO:0016287 - glycerone-phosphate O-acyltransferase activity [Evidence IDA] [PMID 11544256]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IGI,IMP] [PMID 11544256]
AWJ20_1422	Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine; GO_component: GO:0005634 - nucleus [Evidence ISA] [PMID 10392447]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence ISA] [PMID 10392447]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence ISA] [PMID 10392447]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]
AWJ20_1423	Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10373505]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10373505]; GO_function: GO:0030295 - protein kinase activator activity [Evidence IGI,IPI] [PMID 12618390]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 10373505]; GO_process: GO:0071590 - nicotinamide riboside biosynthetic process [Evidence IGI,IMP] [PMID 19846558]; GO_process: GO:0071592 - nicotinic acid riboside biosynthetic process [Evidence IGI,IMP] [PMID 19846558]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP,IPI] [PMID 7667094]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 9725828]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 10373505]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1424	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 19198597]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10610322]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15280434]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9564048]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IPI] [PMID 10428971]; GO_component: GO:0044614 - nuclear pore cytoplasmic filaments [Evidence IDA] [PMID 10610322]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15280434]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 17272721]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence IDA,ISS] [PMID 9564047]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 19805289]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000822 - inositol hexakisphosphate binding [Evidence IDA] [PMID 16783363]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI,IMP] [PMID 9564048]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IGI,IPI] [PMID 17272721]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1426	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0009328 - phenylalanine-tRNA ligase complex [Evidence IDA] [PMID 3049607]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 16162501]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 166841]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 16162501]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 166841]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1427	Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 16839886]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IBA]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IDA,IPI] [PMID 11394869]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IMP] [PMID 2105453]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8756677]; GO_function: GO:0031683 - G-protein beta/gamma-subunit complex binding [Evidence IBA,IEA]; GO_function: GO:0001664 - G-protein coupled receptor binding [Evidence IBA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11394869]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 1900495]; GO_function: GO:0019001 - guanyl nucleotide binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IBA,IEA,IEA]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 12556475]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 2105453]; GO_process: GO:0007189 - adenylate cyclase-activating G-protein coupled receptor signaling pathway [Evidence IBA,IEA]; GO_process: GO:0031684 - heterotrimeric G-protein complex cycle [Evidence IMP] [PMID 2107073]; GO_process: GO:0048017 - inositol lipid-mediated signaling [Evidence IMP] [PMID 16839886]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 3113739]; GO_process: GO:0071701 - regulation of MAPK export from nucleus [Evidence IMP] [PMID 12556475]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA,IEA]
AWJ20_1429	Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes; GO_component: GO:0033565 - ESCRT-0 complex [Evidence IPI] [PMID 12055639]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12055639]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 12055639]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 20150893]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 12055639]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12055639]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1430	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enahnces invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication; GO_component: GO:0061576 - acyl-CoA ceramide synthase complex [Evidence IDA] [PMID 15692566]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IEA]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IMP] [PMID 11387200]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IMP] [PMID 11694577]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IDA] [PMID 15692566]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IMP] [PMID 11694577]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IDA] [PMID 15692566]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IEP,IMP] [PMID 8195187]
AWJ20_1431	Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0000049 - tRNA binding [Evidence ISS] [PMID 9445368]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1433	Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy suppressor of temperature-sensitive ess1 mutations, binds RNA polymerase II large subunit; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 14704159]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 24003114]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 14704159]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_1434	Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0043014 - alpha-tubulin binding [Evidence IPI] [PMID 9885248]; GO_function: GO:0008017 - microtubule binding [Evidence IPI] [PMID 9885248]; GO_process: GO:0007023 - post-chaperonin tubulin folding pathway [Evidence IMP,IPI] [PMID 9885248]; GO_process: GO:0006457 - protein folding [Evidence IMP,IPI] [PMID 9885248]
AWJ20_1435	Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0000780 - condensed nuclear chromosome, centromeric region [Evidence IDA] [PMID 9407032]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0000818 - nuclear MIS12/MIND complex [Evidence IDA] [PMID 14581449]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IEA]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 9407032]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 22561346]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8408221]; GO_process: GO:0051382 - kinetochore assembly [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IMP] [PMID 8408221]
AWJ20_1436	Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8183917]; GO_component: GO:0005968 - Rab-protein geranylgeranyltransferase complex [Evidence IDA] [PMID 8583924]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9202009]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 9202009]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IMP] [PMID 12972569]; GO_function: GO:0004663 - Rab geranylgeranyltransferase activity [Evidence IDA,IMP] [PMID 8183917]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8132658]; GO_process: GO:0032858 - activation of Rab GTPase activity [Evidence IMP] [PMID 7750142]; GO_process: GO:0032858 - activation of Rab GTPase activity [Evidence IMP] [PMID 8132658]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0018344 - protein geranylgeranylation [Evidence IMP] [PMID 12972569]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 8183917]
AWJ20_1437	Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 17176761]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19254924]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15950597]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9802016]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015491 - cation:cation antiporter activity [Evidence ISS] [PMID 8654575]; GO_function: GO:0015491 - cation:cation antiporter activity [Evidence IMP] [PMID 9802016]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IEA]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IDA] [PMID 15950597]; GO_function: GO:0015299 - solute:proton antiporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0030004 - cellular monovalent inorganic cation homeostasis [Evidence IMP] [PMID 9802016]; GO_process: GO:0030007 - cellular potassium ion homeostasis [Evidence IMP] [PMID 16402204]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 16402204]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA,IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1438	Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence TAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 2104804]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence TAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence TAS] [PMID 9559554]; GO_process: GO:0046677 - response to antibiotic [Evidence IEA]; GO_process: GO:0046898 - response to cycloheximide [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1441	Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11694595]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005880 - nuclear microtubule [Evidence IDA] [PMID 11935223]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11694595]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11935223]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0070037 - rRNA (pseudouridine) methyltransferase activity [Evidence IMP,ISO] [PMID 20972225]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0070475 - rRNA base methylation [Evidence IMP,ISO] [PMID 20972225]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11694595]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 11694595]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IGI] [PMID 16721597]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1444	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_1445	Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15710404]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 9614122]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0034707 - chloride channel complex [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17662057]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15710404]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17662057]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17662057]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0005254 - chloride channel activity [Evidence IEA]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IDA] [PMID 12074596]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9614122]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:1902476 - chloride transmembrane transport [Evidence IEA]; GO_process: GO:0006821 - chloride transport [Evidence IEA,IEA]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0044070 - regulation of anion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1446	Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15710404]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 9614122]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0034707 - chloride channel complex [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17662057]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15710404]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17662057]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17662057]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0005254 - chloride channel activity [Evidence IEA]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IDA] [PMID 12074596]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9614122]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:1902476 - chloride transmembrane transport [Evidence IEA]; GO_process: GO:0006821 - chloride transport [Evidence IEA,IEA]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0044070 - regulation of anion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1447	Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence TAS] [PMID 11425802]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004382 - guanosine-diphosphatase activity [Evidence IEA]; GO_function: GO:0004382 - guanosine-diphosphatase activity [Evidence IDA] [PMID 7506254]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0045134 - uridine-diphosphatase activity [Evidence IDA] [PMID 11425802]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence TAS] [PMID 11713596]
AWJ20_1450	Transcription factor required for response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA,IGI,IMP] [PMID 17101777]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IMP] [PMID 8754797]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 8754797]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0046020 - negative regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IEP] [PMID 17101777]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0007329 - positive regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IDA,IEP,IGI,IMP] [PMID 17101777]
AWJ20_1452	Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress; DBP1 has a paralog, DED1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence ISS] [PMID 1857205]; GO_function: GO:0003724 - RNA helicase activity [Evidence ISS] [PMID 8144024]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 14763975]
AWJ20_1453	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 21135091]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 21135091]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IDA] [PMID 12627398]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IGI,ISS] [PMID 9677411]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005543 - phospholipid binding [Evidence IDA] [PMID 21135091]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,ISS] [PMID 9677411]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,ISS] [PMID 9677411]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032312 - regulation of ARF GTPase activity [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1455	Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15975908]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15692048]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0003994 - aconitate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0003994 - aconitate hydratase activity [Evidence IDA,IMP] [PMID 1972545]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 17698960]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 17698960]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 15692048]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IDA] [PMID 1972545]
AWJ20_1457	Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15713625]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 15713625]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016298 - lipase activity [Evidence ISS] [PMID 1574929]; GO_function: GO:0004771 - sterol esterase activity [Evidence IEA]; GO_function: GO:0004771 - sterol esterase activity [Evidence IDA] [PMID 15713625]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 10515935]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 15713625]
AWJ20_1459	Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; GUP1 has a paralog, GUP2, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15813700]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA,ISS] [PMID 10931309]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15813700]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IMP] [PMID 16597698]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IMP] [PMID 18036137]; GO_function: GO:0015293 - symporter activity [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 16597698]; GO_process: GO:0019563 - glycerol catabolic process [Evidence IGI,IMP] [PMID 10747858]; GO_process: GO:0015793 - glycerol transport [Evidence IGI,IMP] [PMID 10931309]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1460	hypothetical protein; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_1461	Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 16565073]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 11401825]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11401825]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12447444]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015301 - anion:anion antiporter activity [Evidence IEA]; GO_function: GO:0080139 - borate efflux transmembrane transporter activity [Evidence IMP,ISA] [PMID 12447444]; GO_function: GO:0080139 - borate efflux transmembrane transporter activity [Evidence IMP] [PMID 16923078]; GO_function: GO:0080139 - borate efflux transmembrane transporter activity [Evidence IDA,IMP] [PMID 17459946]; GO_function: GO:0005452 - inorganic anion exchanger activity [Evidence IEA]; GO_process: GO:0006820 - anion transport [Evidence IEA]; GO_process: GO:0046713 - borate transport [Evidence IMP,ISA] [PMID 12447444]; GO_process: GO:0046713 - borate transport [Evidence IMP] [PMID 16923078]; GO_process: GO:0046713 - borate transport [Evidence IDA,IMP] [PMID 17459946]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 16565073]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1463	Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10880451]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10880451]; GO_component: GO:0031371 - ubiquitin conjugating enzyme complex [Evidence IPI] [PMID 10089880]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,ISS] [PMID 10089880]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISS] [PMID 9576943]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0010994 - free ubiquitin chain polymerization [Evidence IDA] [PMID 19706603]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IMP] [PMID 10089880]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IMP] [PMID 9576943]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA,IPI] [PMID 10089880]
AWJ20_1464	Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IC] [PMID 11823431]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 10684247]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1465	Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1466	hypothetical protein; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 12628920]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1467	Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase (HDAC) complexes; APCC(Cdh1) substrate; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12464632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12464632]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 12760057]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 22333912]
AWJ20_1468	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; GO_component: GO:0070319 - Golgi to plasma membrane transport vesicle [Evidence IDA] [PMID 2163397]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23623749]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8557688]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004605 - phosphatidate cytidylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004605 - phosphatidate cytidylyltransferase activity [Evidence IDA] [PMID 8557688]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic process [Evidence IMP] [PMID 2832385]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IMP] [PMID 2832385]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IMP] [PMID 8557688]; GO_process: GO:0006658 - phosphatidylserine metabolic process [Evidence IMP] [PMID 2832385]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
AWJ20_1469	Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24759102]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24759102]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 22204397]; GO_function: GO:0000309 - nicotinamide-nucleotide adenylyltransferase activity [Evidence IDA,IGI] [PMID 24759102]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP,IPI] [PMID 22204397]; GO_process: GO:0034356 - NAD biosynthesis via nicotinamide riboside salvage pathway [Evidence IGI] [PMID 24759102]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IGI] [PMID 21460040]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 21460040]
AWJ20_1470	GPI-anchored hypothetical protein; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12583915]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 15583168]
AWJ20_1471	Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12676688]; GO_function: GO:0008732 - L-allo-threonine aldolase activity [Evidence IDA] [PMID 9151955]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA,IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0004793 - threonine aldolase activity [Evidence IDA] [PMID 9163906]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IEA]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IDA] [PMID 3086094]; GO_process: GO:0006567 - threonine catabolic process [Evidence IDA] [PMID 3086094]
AWJ20_1472	Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 2517480]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 3533916]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 385049]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0070181 - small ribosomal subunit rRNA binding [Evidence IDA] [PMID 2517480]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 2517480]; GO_process: GO:0045903 - positive regulation of translational fidelity [Evidence IMP] [PMID 17545469]; GO_process: GO:0045903 - positive regulation of translational fidelity [Evidence IMP] [PMID 3522920]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 16246728]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1473	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence ISS] [PMID 7685904]; GO_component: GO:0016020 - membrane [Evidence IBA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005528 - FK506 binding [Evidence IDA] [PMID 1380159]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IBA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence ISS] [PMID 7685904]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0018208 - peptidyl-proline modification [Evidence IBA]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA]
AWJ20_1474	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence ISS] [PMID 7685904]; GO_component: GO:0016020 - membrane [Evidence IBA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005528 - FK506 binding [Evidence IDA] [PMID 1380159]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IBA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence ISS] [PMID 7685904]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0018208 - peptidyl-proline modification [Evidence IBA]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA]
AWJ20_1475	Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090; GO_component: GO:0072546 - ER membrane protein complex [Evidence IEA]; GO_component: GO:0072546 - ER membrane protein complex [Evidence IDA] [PMID 19325107]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 19325107]
AWJ20_1477	mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP); GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 12631707]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0070390 - transcription export complex 2 [Evidence IDA] [PMID 15311284]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12411502]; GO_process: GO:0030029 - actin filament-based process [Evidence IGI] [PMID 2656401]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 12411502]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI,IMP,IPI] [PMID 12631707]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IMP] [PMID 8799844]; GO_process: GO:0071033 - nuclear retention of pre-mRNA at the site of transcription [Evidence IMP] [PMID 18003937]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 18003937]; GO_process: GO:0006611 - protein export from nucleus [Evidence IGI,IMP] [PMID 10716708]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1480	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; PPZ1 has a paralog, PPZ2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 16166647]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8824289]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004724 - magnesium-dependent protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 7615085]; GO_process: GO:0034613 - cellular protein localization [Evidence IMP] [PMID 21237705]; GO_process: GO:0006883 - cellular sodium ion homeostasis [Evidence IGI,IMP] [PMID 7768897]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 21237705]
AWJ20_1486	Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1487	Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12807768]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,ISS] [PMID 10559187]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 15574876]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]
AWJ20_1488	Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 17095012]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 19703468]
AWJ20_1489	Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 10207081]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10207081]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 10207081]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 10526184]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 10588647]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 8852836]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IMP] [PMID 10588647]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IGI,IPI] [PMID 19955214]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IGI] [PMID 8852836]; GO_process: GO:0090338 - positive regulation of formin-nucleated actin cable assembly [Evidence IGI,IMP] [PMID 12810699]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_1496	One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; GO_component: GO:0000815 - ESCRT III complex [Evidence IDA] [PMID 12194857]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9606181]; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 9606181]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
AWJ20_1499	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence NAS] [PMID 1634528]; GO_component: GO:0005737 - cytoplasm [Evidence NAS] [PMID 8175766]; GO_component: GO:0005737 - cytoplasm [Evidence NAS] [PMID 8617732]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 1634528]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence NAS] [PMID 1634528]; GO_component: GO:0005634 - nucleus [Evidence NAS] [PMID 8175766]; GO_component: GO:0005634 - nucleus [Evidence NAS] [PMID 8617732]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0052929 - ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity [Evidence IEA]; GO_function: GO:0052928 - CTP:3'-cytidine-tRNA cytidylyltransferase activity [Evidence IEA]; GO_function: GO:0052927 - CTP:tRNA cytidylyltransferase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004810 - tRNA adenylyltransferase activity [Evidence IDA] [PMID 1634528]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0001680 - tRNA 3'-terminal CCA addition [Evidence IEA]; GO_process: GO:0001680 - tRNA 3'-terminal CCA addition [Evidence IDA] [PMID 1634528]
AWJ20_1500	Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8909536]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA,IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IDA] [PMID 9990311]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IMP] [PMID 11839781]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IDA] [PMID 15772160]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IEA]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IMP] [PMID 22573892]
AWJ20_1502	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1503	Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p; GO_component: GO:0032301 - MutSalpha complex [Evidence IPI] [PMID 8816473]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000228 - nuclear chromosome [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 9545323]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9819445]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IBA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IBA]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 10066781]; GO_function: GO:0032137 - guanine/thymine mispair binding [Evidence IDA] [PMID 8816473]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032138 - single base insertion or deletion binding [Evidence IMP] [PMID 10347163]; GO_function: GO:0032138 - single base insertion or deletion binding [Evidence IDA] [PMID 8816473]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IBA]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IDA] [PMID 11237611]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 2685551]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 9520271]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IBA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IBA]; GO_process: GO:0009411 - response to UV [Evidence IBA]
AWJ20_1504	Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15753074]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 8537371]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8537371]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0019205 - nucleobase-containing compound kinase activity [Evidence IEA]; GO_function: GO:0046899 - nucleoside triphosphate adenylate kinase activity [Evidence IEA]; GO_function: GO:0046899 - nucleoside triphosphate adenylate kinase activity [Evidence IDA] [PMID 15753074]; GO_function: GO:0046899 - nucleoside triphosphate adenylate kinase activity [Evidence IDA] [PMID 8537371]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016776 - phosphotransferase activity, phosphate group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IDA] [PMID 15753074]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_1505	Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17395151]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IMP] [PMID 12429834]; GO_process: GO:0015696 - ammonium transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEP,IMP] [PMID 12429834]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 12429834]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1506	High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1508	Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 2642897]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0001002 - RNA polymerase III type 1 promoter sequence-specific DNA binding [Evidence IDA] [PMID 2642897]; GO_function: GO:0001152 - RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity [Evidence IDA,IMP] [PMID 8496187]; GO_function: GO:0001156 - TFIIIC-class transcription factor binding [Evidence IC] [PMID 8496187]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0042791 - 5S class rRNA transcription from RNA polymerase III type 1 promoter [Evidence IDA] [PMID 2642897]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1510	top hit is XP_007271903.1 originated in Fomitiporia mediterranea MF3/22
AWJ20_1511	Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IEA]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IMP] [PMID 10589830]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IDA] [PMID 17580971]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IDA,IMP] [PMID 21334283]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 10589830]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
AWJ20_1512	Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 16107694]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 16107694]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1513	NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 10781551]; GO_component: GO:0009331 - glycerol-3-phosphate dehydrogenase complex [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0004367 - glycerol-3-phosphate dehydrogenase [NAD+] activity [Evidence IEA,IEA]; GO_function: GO:0004367 - glycerol-3-phosphate dehydrogenase [NAD+] activity [Evidence IMP] [PMID 9171333]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IMP] [PMID 9171333]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IMP] [PMID 9171333]; GO_process: GO:0046168 - glycerol-3-phosphate catabolic process [Evidence IEA]; GO_process: GO:0006072 - glycerol-3-phosphate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1517	tRNA 2'-phosphotransferase; catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22391451]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22391451]; GO_function: GO:0000215 - tRNA 2'-phosphotransferase activity [Evidence IEA]; GO_function: GO:0000215 - tRNA 2'-phosphotransferase activity [Evidence IDA] [PMID 9148937]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IDA] [PMID 9148937]
AWJ20_1518	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 8980231]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1396591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1549132]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 9799253]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0004386 - helicase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0070577 - lysine-acetylated histone binding [Evidence IDA] [PMID 20126658]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 10025404]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 8980231]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 9799253]; GO_process: GO:0006284 - base-excision repair [Evidence IMP] [PMID 24674626]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0031055 - chromatin remodeling at centromere [Evidence IMP] [PMID 12697820]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 12697820]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IGI,IMP] [PMID 12072455]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16024655]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 10320476]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0016584 - nucleosome positioning [Evidence IMP] [PMID 21343911]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 10320476]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 10329629]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
AWJ20_1521	hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1522	Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004725 - protein tyrosine phosphatase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0035335 - peptidyl-tyrosine dephosphorylation [Evidence IEA]
AWJ20_1523	Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner; GO_component: GO:0009331 - glycerol-3-phosphate dehydrogenase complex [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISS] [PMID 8256521]; GO_function: GO:0004368 - glycerol-3-phosphate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004368 - glycerol-3-phosphate dehydrogenase activity [Evidence IDA] [PMID 12032156]; GO_function: GO:0004368 - glycerol-3-phosphate dehydrogenase activity [Evidence IMP,ISS] [PMID 8256521]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0052590 - sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity [Evidence IEA]; GO_function: GO:0052591 - sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 12032156]; GO_process: GO:0019563 - glycerol catabolic process [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IMP] [PMID 8256521]; GO_process: GO:0006072 - glycerol-3-phosphate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 18381895]
AWJ20_1525	Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9705508]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IDA,IMP] [PMID 16215179]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0001046 - core promoter sequence-specific DNA binding [Evidence IDA] [PMID 1495962]; GO_function: GO:0001046 - core promoter sequence-specific DNA binding [Evidence IDA] [PMID 2683089]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 1495962]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 1495962]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 3303332]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1526	Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004059 - aralkylamine N-acetyltransferase activity [Evidence IDA] [PMID 11559708]; GO_function: GO:0004145 - diamine N-acetyltransferase activity [Evidence IDA,IMP] [PMID 15723835]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 15723835]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
AWJ20_1527	DNA damage-inducible v-SNARE binding protein; role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10330187]; GO_function: GO:0000149 - SNARE binding [Evidence IDA] [PMID 10330187]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence ISA] [PMID 11516960]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 11323716]; GO_process: GO:0009306 - protein secretion [Evidence IMP] [PMID 21094643]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12051757]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IMP] [PMID 10330187]
AWJ20_1529	Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1986247]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 1986247]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 8846888]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 8846888]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:2001158 - positive regulation of proline catabolic process to glutamate [Evidence IMP] [PMID 2689862]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2689862]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8846888]; GO_process: GO:0006560 - proline metabolic process [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 22579222]
AWJ20_1530	Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15208443]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15208443]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15208443]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1531	Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15208443]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15208443]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15208443]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1532	Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 15964808]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15964808]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15964808]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 16772403]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 16772403]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15964808]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15964808]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15964808]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0034462 - small-subunit processome assembly [Evidence IMP] [PMID 15964808]
AWJ20_1533	Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence TAS] [PMID 10601196]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_function: GO:0003980 - UDP-glucose:glycoprotein glucosyltransferase activity [Evidence IEA]; GO_function: GO:0003980 - UDP-glucose:glycoprotein glucosyltransferase activity [Evidence IDA] [PMID 9611196]; GO_process: GO:0006078 - (1->6)-beta-D-glucan biosynthetic process [Evidence TAS] [PMID 8550469]; GO_process: GO:0097359 - UDP-glucosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_1535	3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs; GO_component: GO:0045025 - mitochondrial degradosome [Evidence IDA] [PMID 12426313]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0008859 - exoribonuclease II activity [Evidence IEA]; GO_function: GO:0008859 - exoribonuclease II activity [Evidence IDA] [PMID 12426313]; GO_function: GO:0008859 - exoribonuclease II activity [Evidence IDA] [PMID 17658549]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0090503 - RNA phosphodiester bond hydrolysis, exonucleolytic [Evidence IEA]; GO_process: GO:0000957 - mitochondrial RNA catabolic process [Evidence IMP] [PMID 12426313]; GO_process: GO:0000957 - mitochondrial RNA catabolic process [Evidence IMP] [PMID 9829834]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_1536	Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004427 - inorganic diphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004427 - inorganic diphosphatase activity [Evidence IDA] [PMID 8224193]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IC] [PMID 8224193]
AWJ20_1538	D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 11298766]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016857 - racemase and epimerase activity, acting on carbohydrates and derivatives [Evidence IEA]; GO_function: GO:0004750 - ribulose-phosphate 3-epimerase activity [Evidence IEA,IEA]; GO_function: GO:0004750 - ribulose-phosphate 3-epimerase activity [Evidence IDA,IMP,ISS] [PMID 8929392]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA,IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IMP] [PMID 8929392]
AWJ20_1544	Mitochondrial inner membrane transporter; exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11013234]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9178508]; GO_function: GO:0005310 - dicarboxylic acid transmembrane transporter activity [Evidence IDA] [PMID 11013234]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006839 - mitochondrial transport [Evidence IDA] [PMID 11013234]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_1545	DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence IEA,IEA]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence IPI] [PMID 10693764]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005657 - replication fork [Evidence IEA,IEA]; GO_component: GO:0005657 - replication fork [Evidence IDA,IMP] [PMID 17114583]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 12050116]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IMP,ISS] [PMID 10693764]; GO_function: GO:0051880 - G-quadruplex DNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IGI,IMP,IPI] [PMID 10693764]; GO_process: GO:0044806 - G-quadruplex DNA unwinding [Evidence IMP] [PMID 23657261]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 15907372]; GO_process: GO:0097046 - replication fork progression beyond termination site [Evidence IMP] [PMID 20797631]; GO_process: GO:0000723 - telomere maintenance [Evidence IEA]
AWJ20_1546	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; GO_component: GO:0005962 - mitochondrial isocitrate dehydrogenase complex (NAD+) [Evidence IDA] [PMID 16884682]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8626605]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004449 - isocitrate dehydrogenase (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004449 - isocitrate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 16884682]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006102 - isocitrate metabolic process [Evidence IDA] [PMID 16884682]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
AWJ20_1548	Essential nucleolar protein; required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IPI] [PMID 14690591]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1552	Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in the mobilization of non-polar lipids; found in lipid particles, the endoplasmic reticulum and the mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones; oleic acid inducible; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10617610]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10617610]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0000140 - acylglycerone-phosphate reductase activity [Evidence IEA]; GO_function: GO:0000140 - acylglycerone-phosphate reductase activity [Evidence IMP] [PMID 10617610]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IGI,IMP] [PMID 24187129]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006654 - phosphatidic acid biosynthetic process [Evidence IMP] [PMID 10617610]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI] [PMID 24187129]
AWJ20_1553	Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11500370]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IDA,IPI] [PMID 11500370]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP,IPI] [PMID 11500370]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IDA,IMP,IPI] [PMID 11500370]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 15100437]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1554	Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 17875938]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 17875938]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 17875938]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071466 - cellular response to xenobiotic stimulus [Evidence IMP] [PMID 11943786]; GO_process: GO:0061415 - negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source [Evidence IMP] [PMID 17875938]; GO_process: GO:0035948 - positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17875938]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11943786]; GO_process: GO:0061414 - positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source [Evidence IMP] [PMID 17875938]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1555	Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 2167832]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10501934]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15776235]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005761 - mitochondrial ribosome [Evidence IDA] [PMID 15776235]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IDA] [PMID 12063264]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 10617659]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 2167832]
AWJ20_1558	Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 12358428]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IMP,ISS] [PMID 12358428]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12358428]
AWJ20_1560	Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10385521]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10385521]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 10385521]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 10385521]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12456659]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP,IPI] [PMID 15888545]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1561	Putative paralog of ATR1; but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1562	Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8631921]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IDA] [PMID 9020857]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9182588]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
AWJ20_1563	Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression; GO_component: GO:0000814 - ESCRT II complex [Evidence IDA] [PMID 12194858]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000433 - negative regulation of transcription from RNA polymerase II promoter by glucose [Evidence IMP] [PMID 7785322]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12194858]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
AWJ20_1565	Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 8895471]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0032297 - negative regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 9660930]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP] [PMID 16481473]
AWJ20_1566	3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10359084]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence ISS] [PMID 9396823]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IMP] [PMID 10716935]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI] [PMID 10716935]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 10716935]; GO_process: GO:0002107 - generation of mature 3'-end of 5S rRNA generated by RNA polymerase III [Evidence IMP] [PMID 10716935]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0034415 - tRNA 3'-trailer cleavage, exonucleolytic [Evidence IMP] [PMID 10716935]; GO_process: GO:0034415 - tRNA 3'-trailer cleavage, exonucleolytic [Evidence IGI,IMP] [PMID 18456844]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_1568	Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004754 - saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [Evidence IEA,IEA]; GO_function: GO:0004754 - saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [Evidence IDA] [PMID 17002315]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IMP] [PMID 17247984]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence NAS] [PMID 11752249]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence TAS] [PMID 3928261]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_1569	3-keto sterol reductase; catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11279045]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 12119386]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0000253 - 3-keto sterol reductase activity [Evidence IEA]; GO_function: GO:0000253 - 3-keto sterol reductase activity [Evidence IMP] [PMID 10535978]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 10535978]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]
AWJ20_1570	Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IDA] [PMID 16096264]; GO_function: GO:0015197 - peptide transporter activity [Evidence IMP] [PMID 8264579]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0042937 - tripeptide transporter activity [Evidence IDA] [PMID 16096264]; GO_process: GO:0042938 - dipeptide transport [Evidence IDA] [PMID 16096264]; GO_process: GO:0006857 - oligopeptide transport [Evidence IEA]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015833 - peptide transport [Evidence IMP] [PMID 8264579]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IDA] [PMID 16096264]
AWJ20_1572	Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 3060468]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 3060468]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 2643162]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 3060468]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 12857851]; GO_process: GO:0007015 - actin filament organization [Evidence IMP,IPI] [PMID 8522605]
AWJ20_1573	Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0097373 - MCM core complex [Evidence IDA] [PMID 13679365]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7708676]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7708676]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 12480933]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 15723534]; GO_function: GO:1990163 - ATP-dependent four-way junction helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9159120]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IMP] [PMID 17895243]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 15723534]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 10783164]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 2044962]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IGI,IMP] [PMID 10783164]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 13679365]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 15723534]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 19064704]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 19064704]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 2044962]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]
AWJ20_1574	Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 10818358]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0047953 - glycerol 2-dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:1990042 - glycerol dehydrogenase [NAD(P)+] activity [Evidence IMP] [PMID 22979944]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1576	NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11921099]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IEA]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IGI,ISS] [PMID 11921099]; GO_function: GO:0008863 - formate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 21246355]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 11921099]; GO_process: GO:0042183 - formate catabolic process [Evidence IGI] [PMID 19564482]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1577	Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; GO_component: GO:0097078 - FAl1-SGD1 complex [Evidence IPI] [PMID 21576267]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9372960]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISA] [PMID 9372960]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1578	Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; GO_component: GO:0097078 - FAl1-SGD1 complex [Evidence IPI] [PMID 21576267]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9372960]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISA] [PMID 9372960]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1579	hypothetical protein; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004849 - uridine kinase activity [Evidence IEA]; GO_process: GO:0044211 - CTP salvage [Evidence IEA]; GO_process: GO:0044206 - UMP salvage [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_1582	Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 8097278]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 7902576]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9256426]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 10869431]; GO_function: GO:0051087 - chaperone binding [Evidence IPI] [PMID 9256426]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 10869431]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 1359644]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 1978929]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IMP] [PMID 2645524]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 1347713]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 8097278]; GO_process: GO:0042026 - protein refolding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IMP] [PMID 1359644]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9256426]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 1359644]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_1585	Histone variant H2AZ; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA,IPI] [PMID 11081628]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA,IPI] [PMID 11090616]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24390141]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IGI,ISS] [PMID 11000274]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11081628]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 21357739]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI,IPI] [PMID 11090616]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 17660569]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 11081628]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1586	T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005960 - glycine cleavage complex [Evidence ISS] [PMID 9047339]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004047 - aminomethyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IMP] [PMID 9047339]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IC] [PMID 9047339]; GO_process: GO:0006544 - glycine metabolic process [Evidence IMP] [PMID 9047339]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI,IMP] [PMID 10871621]
AWJ20_1588	Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005756 - mitochondrial proton-transporting ATP synthase, central stalk [Evidence IDA] [PMID 17082766]; GO_component: GO:0005756 - mitochondrial proton-transporting ATP synthase, central stalk [Evidence IMP] [PMID 7929329]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA,IEA]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15294286]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IMP] [PMID 7929329]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP] [PMID 7929329]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1590	Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence ISS] [PMID 9259571]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence ISS] [PMID 9259571]
AWJ20_1591	Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15649438]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IMP] [PMID 15649438]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 21148207]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IGI] [PMID 23966878]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IMP] [PMID 15649438]; GO_process: GO:0010509 - polyamine homeostasis [Evidence IMP] [PMID 21148207]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1592	Ubiquitin-protein ligase; functions in ER retention of misfolded proteins; required for ER-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000838 - Hrd1p ubiquitin ligase ERAD-M complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 11139575]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9437001]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 11139575]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IGI,IMP] [PMID 11146622]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP,IPI] [PMID 11146622]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22298424]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 22298424]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 18971375]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 24292014]
AWJ20_1596	Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form translocated to the mitochondrial matrix; GRX2 has a paralog, GRX1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11958675]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11958675]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IMP,ISS] [PMID 9571241]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 12684511]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 18992757]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IDA] [PMID 12684511]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 9571241]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_1597	Fungal Genetics Stock Center 12068; Fungal Genetics Stock Center 12069
AWJ20_1600	hypothetical protein; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1601	Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0004784 - superoxide dismutase activity [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IEA]
AWJ20_1602	Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; GO_component: GO:0000814 - ESCRT II complex [Evidence IDA] [PMID 12194858]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA,IMP] [PMID 15329733]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA,IMP] [PMID 15469844]; GO_process: GO:0000433 - negative regulation of transcription from RNA polymerase II promoter by glucose [Evidence IMP] [PMID 11278625]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12194858]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
AWJ20_1604	Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; GO_component: GO:0000938 - GARP complex [Evidence IPI] [PMID 10637310]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10637310]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 10637310]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 17645731]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IDA] [PMID 12686613]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1607	Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISA] [PMID 1454790]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 1454790]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 1454790]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1608	Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 23193268]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11884397]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IDA] [PMID 23193268]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11884397]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11884397]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11884397]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0034462 - small-subunit processome assembly [Evidence IMP] [PMID 18586827]
AWJ20_1609	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
AWJ20_1610	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
AWJ20_1611	U3 snoRNP protein; component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030869 - RENT complex [Evidence IPI] [PMID 10219244]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1612	Karyopherin responsible for the nuclear import of Rfp1p; Rfp1p is a ribosome maturation factor; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16581791]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA,IMP] [PMID 20219973]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,IPI] [PMID 16581791]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP,IPI] [PMID 20219973]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1614	Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19332891]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 11158587]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 24102742]; GO_component: GO:0005775 - vacuolar lumen [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IDA] [PMID 19332891]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 11158587]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IMP] [PMID 19332891]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0033897 - ribonuclease T2 activity [Evidence IEA,IEA]; GO_process: GO:0006401 - RNA catabolic process [Evidence IMP] [PMID 19332891]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IGI] [PMID 19332891]; GO_process: GO:0000902 - cell morphogenesis [Evidence IMP] [PMID 11158587]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_1616	Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12732713]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9315670]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IEA]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IDA] [PMID 10716984]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IDA] [PMID 16537479]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IEA,IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10535923]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10716984]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 11893751]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IMP] [PMID 8552025]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 10535923]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 5459124]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1617	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has a novel globular fold that is essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of the higher eukaryotic gene Beclin 1; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9105038]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 9105038]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 9712845]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0034271 - phosphatidylinositol 3-kinase complex I [Evidence IDA] [PMID 11157979]; GO_component: GO:0034272 - phosphatidylinositol 3-kinase complex II [Evidence IDA] [PMID 11157979]; GO_component: GO:0034045 - pre-autophagosomal structure membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 9105038]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 9712845]; GO_process: GO:0006914 - autophagy [Evidence IEA,IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 22437838]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 11157979]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 11157979]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 21121900]; GO_process: GO:0006661 - phosphatidylinositol biosynthetic process [Evidence IMP] [PMID 12244127]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IGI,IMP] [PMID 12244127]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1618	Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (Phb1p); GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 22621929]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IBA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IMP] [PMID 22621929]
AWJ20_1619	Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease; MEP3 has a paralog, MEP1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence TAS] [PMID 11486013]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 9234685]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IEA]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IDA,IMP,ISS] [PMID 9234685]; GO_process: GO:0072488 - ammonium transmembrane transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEA,IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IMP,ISS] [PMID 9234685]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 9234685]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1621	Key component of the RAM signaling network; required for proper cell morphogenesis and cell separation after mitosis; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12972564]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 12972564]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12972564]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IMP] [PMID 12972564]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000920 - cytokinetic cell separation [Evidence IMP] [PMID 12972564]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 12972564]
AWJ20_1622	GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IGI,ISS] [PMID 8455603]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IGI,ISS] [PMID 8455603]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IEA]; GO_process: GO:0006997 - nucleus organization [Evidence IGI,ISS] [PMID 8455603]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1625	Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 22411836]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1628	Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2665820]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16850348]; GO_function: GO:0047433 - branched-chain-2-oxoacid decarboxylase activity [Evidence IMP] [PMID 9546164]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IEA]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IDA] [PMID 23423327]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IDA] [PMID 2404950]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IGI] [PMID 12499363]; GO_process: GO:0000955 - amino acid catabolic process via Ehrlich pathway [Evidence IEA]; GO_process: GO:0000949 - aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IDA] [PMID 2404950]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IDA] [PMID 2404950]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IGI] [PMID 12499363]
AWJ20_1629	Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity; GO_component: GO:0005794 - Golgi apparatus [Evidence TAS] [PMID 10397762]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 12200438]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12200438]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004105 - choline-phosphate cytidylyltransferase activity [Evidence IEA]; GO_function: GO:0004105 - choline-phosphate cytidylyltransferase activity [Evidence IDA] [PMID 2826147]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006657 - CDP-choline pathway [Evidence IDA] [PMID 10397762]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA] [PMID 10397762]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
AWJ20_1631	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 22343726]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 22343726]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 15769872]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1632	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IEA]; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IMP] [PMID 9250663]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9335339]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 17895371]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_1633	U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 15565172]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 16314500]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 12773561]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 16314500]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IPI,ISS] [PMID 10688664]
AWJ20_1634	Subunit of the glycosylphosphatidylinositol transamidase complex; transmembrane protein; adds GPIs to newly synthesized proteins; human PIG-Tp homolog; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IEA]; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IDA] [PMID 11598210]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IC,IMP] [PMID 11598210]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP] [PMID 11598210]
AWJ20_1636	Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IMP,IPI] [PMID 10704439]; GO_component: GO:0033597 - mitotic checkpoint complex [Evidence IDA,IPI] [PMID 11726501]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000075 - cell cycle checkpoint [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0032837 - distributive segregation [Evidence IMP] [PMID 15951820]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IGI] [PMID 16651657]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI,IMP] [PMID 10704439]
AWJ20_1637	Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004638 - phosphoribosylaminoimidazole carboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004638 - phosphoribosylaminoimidazole carboxylase activity [Evidence IMP] [PMID 5767024]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IC] [PMID 5767024]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IMP] [PMID 8939809]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IC] [PMID 5767024]
AWJ20_1639	Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; protein abundance increases in response to DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17079729]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031310 - intrinsic component of vacuolar membrane [Evidence IDA] [PMID 12584253]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0033254 - vacuolar transporter chaperone complex [Evidence IPI] [PMID 11823419]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0008976 - polyphosphate kinase activity [Evidence IDA] [PMID 19390046]; GO_process: GO:0016237 - microautophagy [Evidence IDA,IMP] [PMID 17079729]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IMP] [PMID 11102525]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IMP] [PMID 19390046]; GO_process: GO:0007034 - vacuolar transport [Evidence IDA,IMP] [PMID 17079729]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 11823419]
AWJ20_1640	Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_1641	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IDA] [PMID 12627398]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IGI,ISS] [PMID 9677411]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,ISS] [PMID 9677411]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,ISS] [PMID 9677411]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0032312 - regulation of ARF GTPase activity [Evidence IEA]
AWJ20_1642	Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11583614]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10953080]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000915 - actomyosin contractile ring assembly [Evidence IMP] [PMID 14657029]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1643	Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8543066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 2153142]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 3005242]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_function: GO:0004142 - diacylglycerol cholinephosphotransferase activity [Evidence IEA]; GO_function: GO:0004142 - diacylglycerol cholinephosphotransferase activity [Evidence IDA,IMP] [PMID 3029130]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016780 - phosphotransferase activity, for other substituted phosphate groups [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006657 - CDP-choline pathway [Evidence IDA,IMP] [PMID 3029130]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
AWJ20_1646	Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14756774]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005315 - inorganic phosphate transmembrane transporter activity [Evidence IDA] [PMID 14756774]; GO_process: GO:0006817 - phosphate ion transport [Evidence IDA] [PMID 14756774]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 14756774]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1647	PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15913452]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0016314 - phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [Evidence IEA]; GO_function: GO:0004725 - protein tyrosine phosphatase activity [Evidence IEA]; GO_function: GO:0008138 - protein tyrosine/serine/threonine phosphatase activity [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 11070083]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0035335 - peptidyl-tyrosine dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence NAS] [PMID 11395408]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IGI] [PMID 15913452]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]
AWJ20_1648	hypothetical protein that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 20368989]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 15225602]; GO_process: GO:0016070 - RNA metabolic process [Evidence ISS] [PMID 15225602]; GO_process: GO:0016070 - RNA metabolic process [Evidence IPI] [PMID 16702403]
AWJ20_1649	Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p, Far7p, Far8p, Far9p, Far10p and with the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B; GO_component: GO:0000138 - Golgi trans cisterna [Evidence IDA] [PMID 22782902]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23625923]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0031573 - intra-S DNA damage checkpoint [Evidence IMP] [PMID 22782902]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 22782902]; GO_process: GO:0000321 - re-entry into mitotic cell cycle after pheromone arrest [Evidence IGI] [PMID 12588993]
AWJ20_1652	Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0017136 - NAD-dependent histone deacetylase activity [Evidence IDA] [PMID 11711434]; GO_function: GO:0032041 - NAD-dependent histone deacetylase activity (H3-K14 specific) [Evidence IEA]; GO_function: GO:0097372 - NAD-dependent histone deacetylase activity (H3-K18 specific) [Evidence IEA]; GO_function: GO:0046969 - NAD-dependent histone deacetylase activity (H3-K9 specific) [Evidence IEA]; GO_function: GO:0046970 - NAD-dependent histone deacetylase activity (H4-K16 specific) [Evidence IEA]; GO_function: GO:0045129 - NAD-independent histone deacetylase activity [Evidence IDA] [PMID 11711434]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IEA]; GO_function: GO:0031078 - histone deacetylase activity (H3-K14 specific) [Evidence IEA]; GO_function: GO:0032129 - histone deacetylase activity (H3-K9 specific) [Evidence IEA]; GO_function: GO:0034739 - histone deacetylase activity (H4-K16 specific) [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006325 - chromatin organization [Evidence ISS] [PMID 8962081]; GO_process: GO:0070932 - histone H3 deacetylation [Evidence IEA]; GO_process: GO:0070933 - histone H4 deacetylation [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 11711434]; GO_process: GO:0032874 - positive regulation of stress-activated MAPK cascade [Evidence IMP] [PMID 18487345]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 19379692]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence ISS] [PMID 8962081]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1653	Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA,IEA]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 9990856]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence TAS] [PMID 9887095]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 10412984]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IEA]; GO_process: GO:0051177 - meiotic sister chromatid cohesion [Evidence IMP] [PMID 10412984]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 9335333]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10412984]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IMP] [PMID 10412984]
AWJ20_1654	Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0052904 - N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052903 - N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IMP] [PMID 11154694]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IDA] [PMID 21067138]; GO_function: GO:0052902 - spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052901 - spermine:oxygen oxidoreductase (spermidine-forming) activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006598 - polyamine catabolic process [Evidence IGI,IMP] [PMID 12586697]
AWJ20_1655	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1657	Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015183 - L-aspartate transmembrane transporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0005313 - L-glutamate transmembrane transporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0015297 - antiporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0015292 - uniporter activity [Evidence IDA] [PMID 14622413]; GO_process: GO:0015813 - L-glutamate transport [Evidence IDA] [PMID 14622413]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015810 - aspartate transport [Evidence IDA] [PMID 14622413]; GO_process: GO:0044271 - cellular nitrogen compound biosynthetic process [Evidence IMP] [PMID 14622413]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1658	Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 21665945]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 10527495]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 21665945]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 21710968]; GO_process: GO:0016579 - protein deubiquitination [Evidence ISA] [PMID 19734957]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA,IMP] [PMID 21665945]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_1659	Non-essential hypothetical protein; promoter contains a consensus binding sequence for factor Abf1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_1661	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001128 - RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Evidence IDA] [PMID 9234719]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA] [PMID 9234719]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 9234719]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1663	hypothetical protein; required for survival upon exposure to K1 killer toxin; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1664	Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0047710 - bis(5'-adenosyl)-triphosphatase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IDA] [PMID 12028594]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IDA] [PMID 1653209]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0009164 - nucleoside catabolic process [Evidence IMP] [PMID 9573184]
AWJ20_1671	Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9450962]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 9450962]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_function: GO:0008144 - drug binding [Evidence IMP] [PMID 14638499]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004506 - squalene monooxygenase activity [Evidence IEA,IEA]; GO_function: GO:0004506 - squalene monooxygenase activity [Evidence IMP] [PMID 200835]; GO_function: GO:0004506 - squalene monooxygenase activity [Evidence IDA] [PMID 9450962]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1672	Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9450962]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 9450962]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_function: GO:0008144 - drug binding [Evidence IMP] [PMID 14638499]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004506 - squalene monooxygenase activity [Evidence IEA,IEA]; GO_function: GO:0004506 - squalene monooxygenase activity [Evidence IMP] [PMID 200835]; GO_function: GO:0004506 - squalene monooxygenase activity [Evidence IDA] [PMID 9450962]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1673	Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0009514 - glyoxysome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004474 - malate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004474 - malate synthase activity [Evidence IMP] [PMID 23642236]; GO_function: GO:0004474 - malate synthase activity [Evidence IDA] [PMID 8462696]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IDA] [PMID 8462696]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
AWJ20_1674	Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IEA]; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IMP] [PMID 9250663]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9335339]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 17895371]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_1676	Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12455994]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12455994]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8167411]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 12455994]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8167411]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 8167411]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8167411]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 23906065]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11591390]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 22323294]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 23468594]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10066831]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 11003652]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IMP] [PMID 11595741]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IGI,IPI] [PMID 19955214]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IMP] [PMID 12234925]; GO_process: GO:0060178 - regulation of exocyst localization [Evidence IMP] [PMID 11595741]; GO_process: GO:0031384 - regulation of initiation of mating projection growth [Evidence IMP] [PMID 14734532]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0031106 - septin ring organization [Evidence IMP] [PMID 14517318]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_1677	Alpha subunit of chaperonin-containing T-complex; complex mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
AWJ20_1678	Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 18675371]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11533229]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 18675371]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 16055745]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071456 - cellular response to hypoxia [Evidence IMP] [PMID 19807692]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11533229]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16055745]; GO_process: GO:0035969 - positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12077145]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11238402]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1679	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9710580]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IDA] [PMID 9710580]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9710580]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1682	Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11359917]; GO_component: GO:0005795 - Golgi stack [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,IMP,IPI,ISS] [PMID 10508155]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IDA] [PMID 11118206]
AWJ20_1683	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8608153]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004487 - methylenetetrahydrofolate dehydrogenase (NAD+) activity [Evidence IEA]; GO_function: GO:0004487 - methylenetetrahydrofolate dehydrogenase (NAD+) activity [Evidence IMP,ISS] [PMID 8416923]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IMP] [PMID 8608153]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IDA,IMP] [PMID 8608153]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IDA,IMP] [PMID 8608153]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]
AWJ20_1684	Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11864606]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 11864607]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0008097 - 5S rRNA binding [Evidence IPI] [PMID 11864606]; GO_function: GO:0008312 - 7S RNA binding [Evidence IPI] [PMID 11864606]; GO_function: GO:0019843 - rRNA binding [Evidence IPI] [PMID 11864606]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11864606]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11864606]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 11864606]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 11864607]
AWJ20_1685	Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 22331846]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 21818277]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI] [PMID 15725626]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16418532]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 17538013]; GO_process: GO:0031990 - mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 18258809]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0035392 - maintenance of chromatin silencing at telomere [Evidence IMP] [PMID 16418532]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22110603]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 22331846]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 7813444]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 7862658]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9725905]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 21036941]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 7813444]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22110603]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA,IGI] [PMID 15817685]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12730220]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 8524308]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 16418532]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1686	Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 22331846]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 21818277]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI] [PMID 15725626]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16418532]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 17538013]; GO_process: GO:0031990 - mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 18258809]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0035392 - maintenance of chromatin silencing at telomere [Evidence IMP] [PMID 16418532]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22110603]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 22331846]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 7813444]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 7862658]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9725905]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 21036941]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 7813444]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22110603]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA,IGI] [PMID 15817685]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12730220]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 8524308]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 16418532]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1687	Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; GO_component: GO:0042729 - DASH complex [Evidence IEA]; GO_component: GO:0042729 - DASH complex [Evidence IDA] [PMID 15640796]; GO_component: GO:0042729 - DASH complex [Evidence IDA] [PMID 15664196]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0072686 - mitotic spindle [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 15664196]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 16777964]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 17620411]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 20479465]; GO_process: GO:0008608 - attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 17620411]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA,IEA]; GO_process: GO:0051987 - positive regulation of attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 20479465]; GO_process: GO:0051987 - positive regulation of attachment of spindle microtubules to kinetochore [Evidence IDA] [PMID 20479468]; GO_process: GO:0031116 - positive regulation of microtubule polymerization [Evidence IDA] [PMID 15664196]
AWJ20_1688	Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 19073882]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 19073882]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000145 - exocyst [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 7615633]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0000149 - SNARE binding [Evidence IDA,IPI] [PMID 15835919]; GO_function: GO:0000149 - SNARE binding [Evidence IDA,IPI] [PMID 22114349]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 15835919]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0051601 - exocyst localization [Evidence IMP] [PMID 19073882]; GO_process: GO:0006887 - exocytosis [Evidence IEA,IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0035544 - negative regulation of SNARE complex assembly [Evidence IDA,IPI] [PMID 15835919]; GO_process: GO:0035544 - negative regulation of SNARE complex assembly [Evidence IDA,IGI,IPI] [PMID 22114349]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
AWJ20_1689	EEH16864|polysaccharide deacetylase family protein [Paracoccidioides brasiliensis Pb03]
AWJ20_1691	Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10400670]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IGI,IMP,ISS] [PMID 10400670]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IDA] [PMID 12628916]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015693 - magnesium ion transport [Evidence IEA]; GO_process: GO:0045016 - mitochondrial magnesium ion transport [Evidence IGI,IMP,ISS] [PMID 10400670]; GO_process: GO:0045016 - mitochondrial magnesium ion transport [Evidence IDA] [PMID 12628916]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1693	2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11509667]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0004319 - enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [Evidence IEA]; GO_function: GO:0016631 - enoyl-[acyl-carrier-protein] reductase activity [Evidence IDA] [PMID 11509667]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0019166 - trans-2-enoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 11509667]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IMP] [PMID 11509667]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1694	Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine; GO_component: GO:0005634 - nucleus [Evidence ISA] [PMID 10392447]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence ISA] [PMID 10392447]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence ISA] [PMID 10392447]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]
AWJ20_1695	Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 8982460]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISS] [PMID 9675819]; GO_process: GO:0006513 - protein monoubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0000209 - protein polyubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
AWJ20_1698	Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23285195]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23285195]; GO_component: GO:0042788 - polysomal ribosome [Evidence IPI] [PMID 21277287]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21232131]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 21232131]; GO_function: GO:0045182 - translation regulator activity [Evidence IDA] [PMID 21277287]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0045727 - positive regulation of translation [Evidence IDA] [PMID 21277287]
AWJ20_1702	Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IGI,IPI] [PMID 8336705]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IMP] [PMID 8441423]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IPI] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IPI] [PMID 8336705]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA,IPI] [PMID 9472020]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IMP] [PMID 10805739]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IMP] [PMID 12356745]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 9472020]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IGI,IPI] [PMID 8336705]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IPI] [PMID 8336705]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_1704	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10198019]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 14665464]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8808622]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0009927 - histidine phosphotransfer kinase activity [Evidence IDA,IMP] [PMID 12455952]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005034 - osmosensor activity [Evidence IDA] [PMID 12821642]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IEA]; GO_function: GO:0000155 - phosphorelay sensor kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IDA] [PMID 8808622]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0006469 - negative regulation of protein kinase activity [Evidence IGI,IMP] [PMID 9482735]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA] [PMID 8808622]; GO_process: GO:0018106 - peptidyl-histidine phosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA,IEA]; GO_process: GO:0046777 - protein autophosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0023014 - signal transduction by phosphorylation [Evidence IEA]
AWJ20_1705	hypothetical protein; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence TAS] [PMID 10679030]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence TAS] [PMID 10679030]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI] [PMID 10679030]
AWJ20_1708	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 7975899]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 7975899]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence ISS] [PMID 7975899]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_1710	Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 1618910]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IGI] [PMID 1618910]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007019 - microtubule depolymerization [Evidence IMP] [PMID 19041752]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 9813090]; GO_process: GO:0030541 - plasmid partitioning [Evidence IMP] [PMID 19364922]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 9813090]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618897]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618910]
AWJ20_1713	Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 3528153]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004329 - formate-tetrahydrofolate ligase activity [Evidence IEA,IEA]; GO_function: GO:0004329 - formate-tetrahydrofolate ligase activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity [Evidence IEA]; GO_function: GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity [Evidence IDA] [PMID 3528153]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IDA] [PMID 3528153]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IMP] [PMID 10781559]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
AWJ20_1714	Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7798202]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004729 - oxygen-dependent protoporphyrinogen oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004729 - oxygen-dependent protoporphyrinogen oxidase activity [Evidence IMP] [PMID 7052077]; GO_function: GO:0004729 - oxygen-dependent protoporphyrinogen oxidase activity [Evidence IDA] [PMID 7798202]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]
AWJ20_1715	v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 16699523]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA,IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 11959998]; GO_component: GO:0005801 - cis-Golgi network [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS,NAS] [PMID 9755865]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 11959998]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0048193 - Golgi vesicle transport [Evidence IMP] [PMID 9755865]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11959998]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_1716	Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23637464]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19244244]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004623 - phospholipase A2 activity [Evidence IDA,IMP] [PMID 19244244]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 19244244]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 23637464]; GO_process: GO:0032048 - cardiolipin metabolic process [Evidence IDA,IGI] [PMID 19244244]
AWJ20_1717	Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IEA]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IGI,IMP] [PMID 11477098]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IGI] [PMID 22633490]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IDA] [PMID 7650027]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0001676 - long-chain fatty acid metabolic process [Evidence IEA]; GO_process: GO:0015909 - long-chain fatty acid transport [Evidence IGI] [PMID 12601005]; GO_process: GO:0035336 - long-chain fatty-acyl-CoA metabolic process [Evidence IGI,IMP] [PMID 11477098]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1718	Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0044613 - nuclear pore central transport channel [Evidence IDA] [PMID 18046406]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 9305650]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 8044840]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0005487 - nucleocytoplasmic transporter activity [Evidence IPI] [PMID 17418788]; GO_function: GO:0005487 - nucleocytoplasmic transporter activity [Evidence IGI] [PMID 20647373]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IPI] [PMID 17418788]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 22331846]; GO_process: GO:0006607 - NLS-bearing protein import into nucleus [Evidence IGI] [PMID 15039779]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16418532]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0035392 - maintenance of chromatin silencing at telomere [Evidence IMP] [PMID 16418532]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 8195299]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9001245]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9133678]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9305650]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 8044840]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 9001245]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 9133678]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 9305650]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA] [PMID 15817685]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006606 - protein import into nucleus [Evidence IGI] [PMID 20647373]; GO_process: GO:0036228 - protein targeting to nuclear inner membrane [Evidence IGI] [PMID 21659568]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 8524308]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 10638763]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 11862215]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 16418532]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_1720	Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15728363]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15728363]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15728363]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8921898]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IDA] [PMID 17401378]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IMP,ISS] [PMID 8921898]; GO_function: GO:0005506 - iron ion binding [Evidence IMP,IPI] [PMID 15728363]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 15728363]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IDA] [PMID 17401378]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_1721	ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; the Isw2 complex exhibits basal levels of chromatin binding throughout the genome as well as target-specific chromatin interactions; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide; GO_component: GO:0008623 - CHRAC [Evidence IPI,ISS] [PMID 14673157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11238381]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 19203228]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16227570]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0031491 - nucleosome binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 19203228]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 11238381]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA,IMP] [PMID 16227570]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 17689493]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 14673157]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 17689493]; GO_process: GO:0060195 - negative regulation of antisense RNA transcription [Evidence IGI] [PMID 18075583]; GO_process: GO:0046020 - negative regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IMP] [PMID 12624196]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 15116071]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 17949749]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 16227570]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IGI] [PMID 12504018]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1722	Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21763276]; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 21763276]; GO_component: GO:0031315 - extrinsic component of mitochondrial outer membrane [Evidence IDA] [PMID 21763276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IEA,IEA]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IMP,ISS] [PMID 10480913]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 11445588]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 11875065]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0047066 - phospholipid-hydroperoxide glutathione peroxidase activity [Evidence IDA,IMP] [PMID 11445588]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11445588]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
AWJ20_1723	tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 3312232]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 20844078]; GO_function: GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [Evidence IDA] [PMID 6297798]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0051730 - GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [Evidence IDA] [PMID 8428918]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IDA] [PMID 3277966]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IDA] [PMID 3512545]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 8898194]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0032056 - positive regulation of translation in response to stress [Evidence IMP,IPI] [PMID 20844078]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IMP] [PMID 1537841]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IDA] [PMID 2207062]
AWJ20_1724	Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004631 - phosphomevalonate kinase activity [Evidence IEA]; GO_function: GO:0004631 - phosphomevalonate kinase activity [Evidence IMP] [PMID 1846667]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0010142 - farnesyl diphosphate biosynthetic process, mevalonate pathway [Evidence IMP] [PMID 200835]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IEA]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IMP] [PMID 200835]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0031388 - organic acid phosphorylation [Evidence IMP] [PMID 200835]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_1725	Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 7559417]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004408 - holocytochrome-c synthase activity [Evidence IEA]; GO_function: GO:0004408 - holocytochrome-c synthase activity [Evidence IMP,ISS] [PMID 1499554]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0018063 - cytochrome c-heme linkage [Evidence IMP,ISS] [PMID 1499554]
AWJ20_1726	Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0042719 - mitochondrial intermembrane space protein transporter complex [Evidence IDA] [PMID 9822593]; GO_component: GO:0042719 - mitochondrial intermembrane space protein transporter complex [Evidence IDA] [PMID 9889188]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 9430585]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 9495346]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 12138093]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IEA]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IMP] [PMID 9430585]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IDA] [PMID 9495346]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1727	mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8119957]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence TAS] [PMID 9841679]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8119957]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 9841679]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 3062383]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IDA,IPI] [PMID 15753296]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 2540596]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence ISS] [PMID 3062383]
AWJ20_1729	Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 20578725]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17588950]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20709757]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015369 - calcium:proton antiporter activity [Evidence IMP] [PMID 20578725]; GO_function: GO:0015386 - potassium:proton antiporter activity [Evidence IMP] [PMID 17588950]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IMP] [PMID 17588950]; GO_process: GO:0006818 - hydrogen transport [Evidence IMP] [PMID 20578725]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006813 - potassium ion transport [Evidence IMP] [PMID 17588950]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence IMP] [PMID 17588950]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1731	Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA,IGI,ISS] [PMID 11113186]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IMP,ISS] [PMID 11113186]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0000038 - very long-chain fatty acid metabolic process [Evidence IGI,IMP,IPI] [PMID 11113186]
AWJ20_1732	Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004672 - protein kinase activity [Evidence ISS] [PMID 9020587]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]
AWJ20_1733	Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9742237]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004823 - leucine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004823 - leucine-tRNA ligase activity [Evidence IDA] [PMID 9742237]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006429 - leucyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006429 - leucyl-tRNA aminoacylation [Evidence IDA] [PMID 9742237]; GO_process: GO:0032006 - regulation of TOR signaling [Evidence IMP,IPI] [PMID 22424774]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1734	Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA,IPI] [PMID 9472020]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 8506384]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA,IPI] [PMID 9472020]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 11707417]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP,IPI] [PMID 2038327]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 1986242]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 2038327]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IMP] [PMID 3516411]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 3915540]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_1735	ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10419517]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8955118]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0019904 - protein domain specific binding [Evidence IDA] [PMID 11418596]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18174173]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IGI] [PMID 11410533]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 11389845]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]
AWJ20_1736	ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10419517]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8955118]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0019904 - protein domain specific binding [Evidence IDA] [PMID 11418596]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18174173]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IGI] [PMID 11410533]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 11389845]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]
AWJ20_1739	DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0033699 - DNA 5'-adenosine monophosphate hydrolase activity [Evidence IDA] [PMID 16964241]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI,IMP] [PMID 20399152]
AWJ20_1740	Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independent protein import into ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER; GO_component: GO:0005784 - Sec61 translocon complex [Evidence IDA] [PMID 8612571]; GO_component: GO:0005784 - Sec61 translocon complex [Evidence IDA] [PMID 9252322]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IMP] [PMID 1550957]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IDA] [PMID 9252322]; GO_function: GO:0015197 - peptide transporter activity [Evidence IMP] [PMID 10758167]; GO_function: GO:0005048 - signal sequence binding [Evidence IDA] [PMID 12134063]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 19696741]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 24314051]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 11076036]; GO_process: GO:0044743 - intracellular protein transmembrane import [Evidence IMP] [PMID 24314051]; GO_process: GO:0070843 - misfolded protein transport [Evidence IMP] [PMID 24314051]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 7758110]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 9252322]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 9843581]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 10635318]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 9303298]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1743	Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication; GO_component: GO:0030287 - cell wall-bounded periplasmic space [Evidence IDA] [PMID 383482]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 383482]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0042597 - periplasmic space [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IDA] [PMID 6352682]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0043171 - peptide catabolic process [Evidence IMP] [PMID 3286257]; GO_process: GO:0043171 - peptide catabolic process [Evidence IDA] [PMID 6352682]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_1746	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23222640]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 10072385]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006376 - mRNA splice site selection [Evidence IMP] [PMID 10072385]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]; GO_process: GO:0048026 - positive regulation of mRNA splicing, via spliceosome [Evidence IMP] [PMID 10983980]
AWJ20_1747	Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11687631]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11742990]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11752412]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 18845545]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11742990]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IMP] [PMID 11752412]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11805083]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11687631]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11752412]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11805083]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11742990]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11752412]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11805083]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 11687631]
AWJ20_1748	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8858151]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9575221]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 14761951]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA,IPI] [PMID 8858151]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 9575221]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14761951]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9575221]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 8858151]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 9575221]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 8858151]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IDA] [PMID 8858151]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 10982821]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 8858151]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 9575221]
AWJ20_1751	GTPase activating protein (GAP) for Gsp1p; involved in nuclear transport; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2116418]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8755533]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8755533]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005098 - Ran GTPase activator activity [Evidence IEA]; GO_function: GO:0005098 - Ran GTPase activator activity [Evidence IMP] [PMID 7657689]; GO_function: GO:0005098 - Ran GTPase activator activity [Evidence IDA] [PMID 9305944]; GO_process: GO:0006404 - RNA import into nucleus [Evidence IMP] [PMID 16040803]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 17904525]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032853 - positive regulation of Ran GTPase activity [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IDA] [PMID 7657689]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 11739405]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP] [PMID 11739405]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP] [PMID 22008473]
AWJ20_1752	Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 12504007]; GO_function: GO:0001671 - ATPase activator activity [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 12504007]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 12604615]; GO_function: GO:0051087 - chaperone binding [Evidence IEA]; GO_function: GO:0051087 - chaperone binding [Evidence IDA] [PMID 12504007]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 12504007]; GO_process: GO:0032781 - positive regulation of ATPase activity [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IMP,IPI] [PMID 12504007]; GO_process: GO:0006950 - response to stress [Evidence IEA,IEA]
AWJ20_1753	similar to S. cerevisiae VPS72 (YDR485C) involved in vacuolar protein sorting; Ca20C1.06c; allele of CaO19.3399
AWJ20_1756	Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004830 - tryptophan-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004830 - tryptophan-tRNA ligase activity [Evidence IDA] [PMID 9046085]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006436 - tryptophanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006436 - tryptophanyl-tRNA aminoacylation [Evidence TAS] [PMID 10950302]
AWJ20_1757	3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12595523]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 12595523]; GO_function: GO:0008686 - 3,4-dihydroxy-2-butanone-4-phosphate synthase activity [Evidence IEA,IEA]; GO_function: GO:0008686 - 3,4-dihydroxy-2-butanone-4-phosphate synthase activity [Evidence IMP] [PMID 7559556]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 12595523]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]
AWJ20_1758	Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IMP] [PMID 9675847]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006740 - NADPH regeneration [Evidence IGI] [PMID 19158096]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IGI] [PMID 10919763]; GO_process: GO:0006067 - ethanol metabolic process [Evidence IMP] [PMID 9675847]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 10409655]
AWJ20_1761	Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005684 - U2-type spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]
AWJ20_1762	Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0017102 - methionyl glutamyl tRNA synthetase complex [Evidence IDA] [PMID 11069915]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19417106]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004818 - glutamate-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004818 - glutamate-tRNA ligase activity [Evidence IDA] [PMID 11069915]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006424 - glutamyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006424 - glutamyl-tRNA aminoacylation [Evidence IDA] [PMID 11069915]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
AWJ20_1763	Cytosolic protein required for sporulation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_1764	Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 12682017]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 20732871]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 21737840]; GO_process: GO:0016570 - histone modification [Evidence IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15149594]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15180994]; GO_process: GO:2001165 - positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 18469135]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14710186]; GO_process: GO:0034402 - recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 18469135]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 12667454]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 12876293]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IMP] [PMID 17576814]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:2001166 - regulation of histone H2B ubiquitination [Evidence IMP] [PMID 12876293]; GO_process: GO:2001166 - regulation of histone H2B ubiquitination [Evidence IMP] [PMID 12876294]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12667454]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12876293]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12876294]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 15180994]; GO_process: GO:2001160 - regulation of histone H3-K79 methylation [Evidence IMP] [PMID 12876293]; GO_process: GO:2001163 - regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 15149594]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 11884586]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 16246725]; GO_process: GO:0001015 - snoRNA transcription from an RNA polymerase II promoter [Evidence IMP] [PMID 16246725]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 11927560]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1766	Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 1851947]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003942 - N-acetyl-gamma-glutamyl-phosphate reductase activity [Evidence IEA,IEA]; GO_function: GO:0003942 - N-acetyl-gamma-glutamyl-phosphate reductase activity [Evidence IDA] [PMID 1851947]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0003991 - acetylglutamate kinase activity [Evidence IEA,IEA]; GO_function: GO:0003991 - acetylglutamate kinase activity [Evidence IDA] [PMID 1851947]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence TAS] [PMID 12603335]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006592 - ornithine biosynthetic process [Evidence TAS] [PMID 1851947]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 15486299]
AWJ20_1767	E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA; GO_component: GO:0097505 - Rad6-Rad18 complex [Evidence IDA] [PMID 9287349]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10880451]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10880451]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 7926769]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 9287349]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 9287349]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0042275 - error-free postreplication DNA repair [Evidence IGI] [PMID 10924462]; GO_process: GO:0042275 - error-free postreplication DNA repair [Evidence IGI] [PMID 9576943]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IGI] [PMID 9409821]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 11973297]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 15687278]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IMP] [PMID 12226657]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
AWJ20_1768	Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12361950]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12523934]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12361950]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12523934]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA,IMP] [PMID 12361950]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA] [PMID 12523934]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA,IMP] [PMID 12361950]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 12523934]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_1769	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; YPS1 has a paralog, MKC7, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA] [PMID 8389368]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0016485 - protein processing [Evidence IDA] [PMID 8626758]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_1770	Putative paralog of ATR1; but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1772	S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 22028670]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IMP] [PMID 22028670]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0055088 - lipid homeostasis [Evidence IMP] [PMID 22028670]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]
AWJ20_1773	Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004053 - arginase activity [Evidence IEA,IEA]; GO_function: GO:0004053 - arginase activity [Evidence IMP] [PMID 14582193]; GO_function: GO:0004053 - arginase activity [Evidence IDA] [PMID 2404017]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016813 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IDA] [PMID 1939179]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0090369 - ornithine carbamoyltransferase inhibitor activity [Evidence IDA,IMP] [PMID 12679340]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 1939179]; GO_process: GO:0019547 - arginine catabolic process to ornithine [Evidence IMP] [PMID 14582193]; GO_process: GO:0019547 - arginine catabolic process to ornithine [Evidence IDA] [PMID 2404017]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA,IEA]; GO_process: GO:0090368 - regulation of ornithine metabolic process [Evidence IDA,IMP] [PMID 12679340]; GO_process: GO:0000050 - urea cycle [Evidence IEA]
AWJ20_1774	Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11427965]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11427965]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 11427965]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 17714445]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 17761529]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 11427965]
AWJ20_1775	Putative metalloprotease with similarity to zinc carboxypeptidases; required for normal cell wall assembly; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004181 - metallocarboxypeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence ISS] [PMID 15606766]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence ISS] [PMID 15606766]
AWJ20_1778	N-glycosylated protein; involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11110666]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15356260]; GO_component: GO:0005621 - cellular bud scar [Evidence IDA] [PMID 11110666]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 11110666]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IGI,IMP] [PMID 11110666]
AWJ20_1779	N-glycosylated protein; involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11110666]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15356260]; GO_component: GO:0005621 - cellular bud scar [Evidence IDA] [PMID 11110666]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 11110666]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IGI,IMP] [PMID 11110666]
AWJ20_1780	Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IBA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004817 - cysteine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004817 - cysteine-tRNA ligase activity [Evidence IDA] [PMID 9523015]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006423 - cysteinyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006423 - cysteinyl-tRNA aminoacylation [Evidence IDA] [PMID 9523015]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1781	Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress; GO_component: GO:0030287 - cell wall-bounded periplasmic space [Evidence IDA] [PMID 15128531]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15128531]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IMP] [PMID 7502577]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence IEA]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence IMP] [PMID 7502577]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0071465 - cellular response to desiccation [Evidence IMP] [PMID 8633854]; GO_process: GO:0071361 - cellular response to ethanol [Evidence IMP] [PMID 8633854]; GO_process: GO:0071497 - cellular response to freezing [Evidence IMP] [PMID 8633854]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IMP] [PMID 7502577]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IDA,IMP,ISS] [PMID 8764988]
AWJ20_1782	Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress; GO_component: GO:0030287 - cell wall-bounded periplasmic space [Evidence IDA] [PMID 15128531]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15128531]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IMP] [PMID 7502577]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence IEA]; GO_function: GO:0004555 - alpha,alpha-trehalase activity [Evidence IMP] [PMID 7502577]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0071465 - cellular response to desiccation [Evidence IMP] [PMID 8633854]; GO_process: GO:0071361 - cellular response to ethanol [Evidence IMP] [PMID 8633854]; GO_process: GO:0071497 - cellular response to freezing [Evidence IMP] [PMID 8633854]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IMP] [PMID 7502577]; GO_process: GO:0005993 - trehalose catabolic process [Evidence IDA,IMP,ISS] [PMID 8764988]
AWJ20_1783	Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 17954932]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 12684380]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IDA] [PMID 15713626]; GO_process: GO:0032443 - regulation of ergosterol biosynthetic process [Evidence IGI] [PMID 15713626]; GO_process: GO:0032443 - regulation of ergosterol biosynthetic process [Evidence IMP] [PMID 17954932]
AWJ20_1784	Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued); GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 19403691]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 19403691]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005869 - dynactin complex [Evidence IDA] [PMID 9658168]; GO_component: GO:0030286 - dynein complex [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 19403691]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9658168]; GO_function: GO:0008017 - microtubule binding [Evidence ISS] [PMID 9658168]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IMP] [PMID 9658168]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1785	UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IMP] [PMID 9079905]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0000506 - glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [Evidence TAS] [PMID 11102867]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008194 - UDP-glycosyltransferase activity [Evidence ISS] [PMID 10970797]; GO_function: GO:0017176 - phosphatidylinositol N-acetylglucosaminyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence ISS] [PMID 8081362]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]
AWJ20_1786	Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 16456538]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043328 - protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IGI] [PMID 19369420]
AWJ20_1787	Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0070577 - lysine-acetylated histone binding [Evidence IDA] [PMID 20126658]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA,IDA] [PMID 12183366]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1790	DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 23313845]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23313845]; GO_component: GO:0005657 - replication fork [Evidence IPI] [PMID 11545742]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 10601233]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 9974380]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 23326240]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 10713149]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 10932195]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 11027270]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 9974380]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 10713149]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 12110599]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 16387871]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 23326240]
AWJ20_1795	Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 12455697]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 15755916]; GO_function: GO:0005275 - amine transmembrane transporter activity [Evidence IMP] [PMID 12455697]; GO_process: GO:0015837 - amine transport [Evidence IMP] [PMID 12455697]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 12455697]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 12455697]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1796	Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005838 - proteasome regulatory particle [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 10490625]
AWJ20_1797	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
AWJ20_1798	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
AWJ20_1800	Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function; GO_component: GO:0030132 - clathrin coat of coated pit [Evidence IEA]; GO_component: GO:0030130 - clathrin coat of trans-Golgi network vesicle [Evidence IEA]; GO_component: GO:0030125 - clathrin vesicle coat [Evidence TAS] [PMID 9171338]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence TAS] [PMID 9171338]; GO_process: GO:0006897 - endocytosis [Evidence IDA,IMP] [PMID 16643280]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence TAS] [PMID 9171338]
AWJ20_1801	hypothetical protein that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 23613772]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 10093218]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 16702403]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1802	Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_function: GO:0043014 - alpha-tubulin binding [Evidence IPI] [PMID 9885248]; GO_process: GO:0006457 - protein folding [Evidence IGI,ISS] [PMID 9215891]; GO_process: GO:0007021 - tubulin complex assembly [Evidence IGI] [PMID 9215891]; GO_process: GO:0072668 - tubulin complex biogenesis [Evidence IMP] [PMID 9215891]
AWJ20_1803	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]
AWJ20_1809	Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI-containing proteins; localizes to the cell wall; mRNA induced during sporulation; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence ISS] [PMID 10769178]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 17397106]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]
AWJ20_1811	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10198019]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 14665464]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8808622]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0009927 - histidine phosphotransfer kinase activity [Evidence IDA,IMP] [PMID 12455952]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005034 - osmosensor activity [Evidence IDA] [PMID 12821642]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IEA]; GO_function: GO:0000155 - phosphorelay sensor kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IDA] [PMID 8808622]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0006469 - negative regulation of protein kinase activity [Evidence IGI,IMP] [PMID 9482735]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA] [PMID 8808622]; GO_process: GO:0018106 - peptidyl-histidine phosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA,IEA]; GO_process: GO:0046777 - protein autophosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0023014 - signal transduction by phosphorylation [Evidence IEA]
AWJ20_1812	UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003977 - UDP-N-acetylglucosamine diphosphorylase activity [Evidence IEA]; GO_function: GO:0003977 - UDP-N-acetylglucosamine diphosphorylase activity [Evidence IDA] [PMID 9603950]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IDA] [PMID 9603950]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1819	Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1824	Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1825	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 8433986]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IMP] [PMID 8433986]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0006096 - glycolytic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_1827	Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 3125423]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004657 - proline dehydrogenase activity [Evidence IEA]; GO_function: GO:0004657 - proline dehydrogenase activity [Evidence IDA] [PMID 20450881]; GO_function: GO:0004657 - proline dehydrogenase activity [Evidence IMP] [PMID 387737]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IC] [PMID 387737]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006562 - proline catabolic process [Evidence IEA]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IEA]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IDA] [PMID 20450881]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IMP] [PMID 387737]; GO_process: GO:0006560 - proline metabolic process [Evidence IEA]
AWJ20_1828	Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 13679573]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 22250200]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 23237950]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23237950]; GO_function: GO:0005544 - calcium-dependent phospholipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 15049706]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0090158 - endoplasmic reticulum membrane organization [Evidence IGI] [PMID 23237950]; GO_process: GO:0060304 - regulation of phosphatidylinositol dephosphorylation [Evidence IGI] [PMID 23237950]
AWJ20_1829	t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 9195974]; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 7954793]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 16339720]; GO_function: GO:0005484 - SNAP receptor activity [Evidence ISS] [PMID 7954793]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence TAS] [PMID 10047442]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 12913108]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11001046]
AWJ20_1830	Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0017178 - diphthine-ammonia ligase activity [Evidence IEA]; GO_function: GO:0017178 - diphthine-ammonia ligase activity [Evidence IDA,IMP] [PMID 23169644]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IDA,IMP] [PMID 23169644]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 23468660]
AWJ20_1831	Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0009349 - riboflavin synthase complex [Evidence IEA]; GO_function: GO:0000906 - 6,7-dimethyl-8-ribityllumazine synthase activity [Evidence IGI,ISS] [PMID 7559556]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 7559556]
AWJ20_1832	Nucleolar protein required for 60S ribosomal subunit biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9891085]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9891085]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 9891085]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1833	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 10219085]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10219085]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 15531585]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 11884586]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_function: GO:0045142 - triplex DNA binding [Evidence IDA] [PMID 11058104]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15149594]; GO_process: GO:2001255 - positive regulation of histone H3-K36 trimethylation [Evidence IMP] [PMID 17948059]; GO_process: GO:2001165 - positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 18469135]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 18194564]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:0051569 - regulation of histone H3-K4 methylation [Evidence IMP] [PMID 12667454]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 18194564]; GO_process: GO:0060260 - regulation of transcription initiation from RNA polymerase II promoter [Evidence IMP] [PMID 18194564]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10219085]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 16246725]; GO_process: GO:0001015 - snoRNA transcription from an RNA polymerase II promoter [Evidence IMP] [PMID 16246725]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IMP] [PMID 19164765]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 11927560]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IGI] [PMID 20299458]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1836	Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12588995]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IMP,ISS] [PMID 12588995]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 12588995]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1837	HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8744950]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 3065625]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 8744950]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity [Evidence IEA,IEA]; GO_function: GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity [Evidence IMP] [PMID 2828155]; GO_function: GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity [Evidence IDA] [PMID 3526336]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0015936 - coenzyme A metabolic process [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 9292983]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IC] [PMID 3526336]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_1838	Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0043527 - tRNA methyltransferase complex [Evidence IDA] [PMID 12403464]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IMP] [PMID 12403464]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IDA] [PMID 17382321]; GO_process: GO:0036265 - RNA (guanine-N7)-methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 12403464]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 17382321]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_1839	Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 12566428]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 15965467]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005875 - microtubule associated complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15965467]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_function: GO:0045502 - dynein binding [Evidence IEA]; GO_function: GO:0051010 - microtubule plus-end binding [Evidence IDA] [PMID 15965467]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006928 - cellular component movement [Evidence IEA]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IEA]; GO_process: GO:0007017 - microtubule-based process [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 12566428]; GO_process: GO:2000582 - positive regulation of plus-end-directed microtubule motor activity [Evidence IMP] [PMID 22939623]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1840	Protein required for normal mitochondrial morphology; has similarity to hemolysins; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IMP] [PMID 15498024]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 10628851]
AWJ20_1841	Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IMP] [PMID 3023838]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 3282541]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006113 - fermentation [Evidence IMP] [PMID 3023838]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1844	Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IBA]; GO_function: GO:0004134 - 4-alpha-glucanotransferase activity [Evidence IEA,IEA]; GO_function: GO:0004134 - 4-alpha-glucanotransferase activity [Evidence IDA,IMP] [PMID 11094287]; GO_function: GO:0004135 - amylo-alpha-1,6-glucosidase activity [Evidence IEA,IEA]; GO_function: GO:0004135 - amylo-alpha-1,6-glucosidase activity [Evidence IDA,IMP] [PMID 11094287]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0005980 - glycogen catabolic process [Evidence IEA]; GO_process: GO:0005980 - glycogen catabolic process [Evidence IMP] [PMID 11094287]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1846	RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IEA]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12697831]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IMP] [PMID 12697831]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1847	top hit is XP_002839470.1 originated in Tuber melanosporum Mel28; conserved fungal protein
AWJ20_1848	Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9726978]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11120744]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IGI] [PMID 11120744]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,IMP] [PMID 10341420]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,IMP] [PMID 9726978]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015891 - siderophore transport [Evidence IMP] [PMID 9726978]
AWJ20_1849	Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12694636]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12694636]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 12694636]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence ISS] [PMID 7925273]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA,ISS] [PMID 7925273]
AWJ20_1850	Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1851	Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004476 - mannose-6-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004476 - mannose-6-phosphate isomerase activity [Evidence IDA] [PMID 8011630]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IMP] [PMID 1377774]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 1377774]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 1377774]
AWJ20_1853	SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 12391157]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16824951]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 16824951]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 12391157]; GO_process: GO:0045010 - actin nucleation [Evidence IMP] [PMID 16824951]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 16231105]; GO_process: GO:0009651 - response to salt stress [Evidence IGI,IPI] [PMID 12391157]
AWJ20_1854	Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 8702493]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IPI] [PMID 10889207]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IMP] [PMID 8702493]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 8702493]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_1857	top hit is XP_002839470.1 originated in Tuber melanosporum Mel28; conserved fungal protein
AWJ20_1858	Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 7607232]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004818 - glutamate-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004818 - glutamate-tRNA ligase activity [Evidence ISA] [PMID 7607232]; GO_function: GO:0050561 - glutamate-tRNA(Gln) ligase activity [Evidence IDA] [PMID 15706032]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0006424 - glutamyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006424 - glutamyl-tRNA aminoacylation [Evidence ISA] [PMID 7607232]; GO_process: GO:0070149 - mitochondrial glutamyl-tRNA aminoacylation [Evidence IC] [PMID 7607232]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 7607232]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1859	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IEA]; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IDA] [PMID 15738391]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11927594]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 21293191]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IDA] [PMID 15738391]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 16793545]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 21293191]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 11927594]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15738391]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0051304 - chromosome separation [Evidence IMP] [PMID 15793567]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IEA]; GO_process: GO:0000725 - recombinational repair [Evidence IPI] [PMID 19995966]; GO_process: GO:0071139 - resolution of recombination intermediates [Evidence IMP] [PMID 20159973]
AWJ20_1863	Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004594 - pantothenate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004594 - pantothenate kinase activity [Evidence IMP] [PMID 19266201]; GO_function: GO:0004594 - pantothenate kinase activity [Evidence ISS] [PMID 9890959]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 9890959]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_1864	AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003877 - ATP adenylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008796 - bis(5'-nucleosyl)-tetraphosphatase activity [Evidence IDA,IGI,IMP] [PMID 2174863]; GO_function: GO:0008796 - bis(5'-nucleosyl)-tetraphosphatase activity [Evidence IDA,IMP] [PMID 2556364]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004780 - sulfate adenylyltransferase (ADP) activity [Evidence IEA]; GO_function: GO:0004780 - sulfate adenylyltransferase (ADP) activity [Evidence IDA,IMP] [PMID 2556364]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009164 - nucleoside catabolic process [Evidence IDA,IGI,IMP] [PMID 2174863]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IDA] [PMID 2172926]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA]
AWJ20_1865	Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 8643404]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008173 - RNA methyltransferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008989 - rRNA (guanine-N1-)-methyltransferase activity [Evidence IDA] [PMID 8643404]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0000154 - rRNA modification [Evidence IDA] [PMID 8643404]
AWJ20_1866	Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IEA]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IMP] [PMID 2540976]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 2540976]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IMP] [PMID 2540976]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 11556808]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_1868	Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004424 - imidazoleglycerol-phosphate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0004424 - imidazoleglycerol-phosphate dehydratase activity [Evidence IMP] [PMID 14190241]; GO_function: GO:0004424 - imidazoleglycerol-phosphate dehydratase activity [Evidence IDA] [PMID 341150]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IDA] [PMID 341150]
AWJ20_1869	Putative hydrolase acting on ester bonds; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
AWJ20_1871	similar to Coprinopsis cinerea okayama7#130 XP_001830383.1
AWJ20_1872	Histone chaperone; involved in histone exchange by removing and replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; involved in the transport of H2A and H2B histones to the nucleus; required for the regulation of microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7622566]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10767562]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0030332 - cyclin binding [Evidence IPI] [PMID 7622566]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 22308335]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 17289584]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 21348863]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI,IMP] [PMID 13680156]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 1400414]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA,ISS] [PMID 2016313]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IDA] [PMID 22308335]; GO_process: GO:0031116 - positive regulation of microtubule polymerization [Evidence IMP] [PMID 7622567]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 22308335]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12456659]
AWJ20_1874	Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000502 - proteasome complex [Evidence IDA] [PMID 12408819]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0034450 - ubiquitin-ubiquitin ligase activity [Evidence IDA] [PMID 17190603]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17190603]; GO_process: GO:0010994 - free ubiquitin chain polymerization [Evidence IMP] [PMID 22497224]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA] [PMID 17190603]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]
AWJ20_1879	Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1881	Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer; GO_component: GO:0032389 - MutLalpha complex [Evidence IPI] [PMID 10570173]; GO_component: GO:0097587 - MutLgamma complex [Evidence IPI] [PMID 9770499]; GO_component: GO:0005712 - chiasma [Evidence IBA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000795 - synaptonemal complex [Evidence IBA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 10938116]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 11717305]; GO_function: GO:0032135 - DNA insertion or deletion binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0032139 - dinucleotide insertion or deletion binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 11575920]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 11575920]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000713 - meiotic heteroduplex formation [Evidence IMP] [PMID 15654114]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 23316435]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 2685551]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10570173]
AWJ20_1882	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IEA]; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IDA] [PMID 15738391]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IDA] [PMID 15738391]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15738391]; GO_process: GO:0006281 - DNA repair [Evidence IMP,IPI] [PMID 15752197]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]
AWJ20_1883	Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; when directed to the cytoplasm, complements the essential function of Kae1p in the KEOPS complex; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0072670 - mitochondrial tRNA threonylcarbamoyladenosine modification [Evidence IMP] [PMID 21183954]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0070526 - threonylcarbamoyladenosine biosynthetic process [Evidence IEA]; GO_process: GO:0070526 - threonylcarbamoyladenosine biosynthetic process [Evidence IDA] [PMID 23620299]
AWJ20_1884	Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 8801420]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence ISS] [PMID 10407263]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IMP] [PMID 12586697]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0019483 - beta-alanine biosynthetic process [Evidence IMP] [PMID 12586697]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence ISS] [PMID 10407263]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IEA]; GO_process: GO:0006598 - polyamine catabolic process [Evidence IGI,IMP] [PMID 12586697]
AWJ20_1885	Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10805735]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IDA] [PMID 21987576]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence ISA] [PMID 10748136]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IGI,IMP] [PMID 17259550]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 10748136]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IGI,IMP] [PMID 10805735]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12065597]
AWJ20_1886	F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346238]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346239]; GO_component: GO:0043224 - nuclear SCF ubiquitin ligase complex [Evidence IDA] [PMID 11080155]; GO_component: GO:0016363 - nuclear matrix [Evidence IDA] [PMID 2244914]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11080155]; GO_function: GO:0050815 - phosphoserine binding [Evidence IDA] [PMID 23314252]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_function: GO:0061630 - ubiquitin protein ligase activity [Evidence IDA] [PMID 9346238]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 9346239]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10409741]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 10409741]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 7954792]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 328339]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_1889	Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 8649384]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 8514129]
AWJ20_1890	Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15103330]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 15103330]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0008901 - ferredoxin hydrogenase activity [Evidence ISS] [PMID 10514485]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IDA] [PMID 19385603]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 15103330]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 19385603]
AWJ20_1891	Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidative stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004345 - glucose-6-phosphate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004345 - glucose-6-phosphate dehydrogenase activity [Evidence IMP] [PMID 2001672]; GO_function: GO:0004345 - glucose-6-phosphate dehydrogenase activity [Evidence IMP] [PMID 2269430]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006740 - NADPH regeneration [Evidence IMP] [PMID 2269430]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0045013 - carbon catabolite repression of transcription [Evidence IMP] [PMID 2269430]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]; GO_process: GO:0009051 - pentose-phosphate shunt, oxidative branch [Evidence IMP] [PMID 7045591]; GO_process: GO:0009051 - pentose-phosphate shunt, oxidative branch [Evidence IMP] [PMID 8299150]; GO_process: GO:0042542 - response to hydrogen peroxide [Evidence IMP] [PMID 7586028]; GO_process: GO:0042542 - response to hydrogen peroxide [Evidence IMP] [PMID 9480895]
AWJ20_1892	Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004343 - glucosamine 6-phosphate N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004343 - glucosamine 6-phosphate N-acetyltransferase activity [Evidence IDA] [PMID 9867860]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IEA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IDA,IMP] [PMID 9867860]
AWJ20_1893	Putative dihydrokaempferol 4-reductase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence ISA] [PMID 19577617]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_1894	Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 21971548]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 21971548]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_1895	NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 4126]; GO_function: GO:0004354 - glutamate dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:0004354 - glutamate dehydrogenase (NADP+) activity [Evidence IDA] [PMID 11562373]; GO_function: GO:0004354 - glutamate dehydrogenase (NADP+) activity [Evidence IDA,IMP] [PMID 2932370]; GO_function: GO:0004354 - glutamate dehydrogenase (NADP+) activity [Evidence IDA,IMP] [PMID 2989290]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016639 - oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0019676 - ammonia assimilation cycle [Evidence IEP] [PMID 11356843]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IGI] [PMID 2932370]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IGI] [PMID 2989290]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1896	Probable type-III integral membrane hypothetical protein; has regions of similarity to mitochondrial electron transport proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 8635735]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1897	Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 1869583]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8144572]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 1869583]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 1400408]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 15342786]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9774392]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 10567418]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 15342786]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9674429]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1473150]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IMP] [PMID 1729605]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1898	Subunit of both the ERMES and the SAM complex; component of ERMES complex which acts as a molecular tether between the mitochondria and the ER, necessary for efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex component that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; GO_component: GO:0032865 - ERMES complex [Evidence IEA,IEA]; GO_component: GO:0032865 - ERMES complex [Evidence IPI] [PMID 13679517]; GO_component: GO:0032865 - ERMES complex [Evidence IPI] [PMID 17410204]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0001401 - mitochondrial sorting and assembly machinery complex [Evidence IPI] [PMID 17410204]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051654 - establishment of mitochondrion localization [Evidence IMP] [PMID 13679517]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IEA]; GO_process: GO:0070096 - mitochondrial outer membrane translocase complex assembly [Evidence IMP] [PMID 15239954]; GO_process: GO:0070096 - mitochondrial outer membrane translocase complex assembly [Evidence IMP,IPI] [PMID 20026336]; GO_process: GO:0007005 - mitochondrion organization [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 19556461]; GO_process: GO:0015914 - phospholipid transport [Evidence IGI] [PMID 19556461]; GO_process: GO:0006461 - protein complex assembly [Evidence IEA]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IEA]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IMP] [PMID 17410204]
AWJ20_1900	Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10077572]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IEA]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IDA] [PMID 10600176]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 10077572]
AWJ20_1901	Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as a receptor for precursor proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005742 - mitochondrial outer membrane translocase complex [Evidence IDA] [PMID 9774667]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015266 - protein channel activity [Evidence IMP] [PMID 10519552]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 10519552]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 9774667]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IMP] [PMID 12628251]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1902	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_1903	Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IC] [PMID 9643541]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 19767828]
AWJ20_1904	Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 10608875]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005381 - iron ion transmembrane transporter activity [Evidence TAS] [PMID 10608875]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]; GO_process: GO:0006827 - high-affinity iron ion transport [Evidence IPI] [PMID 10608875]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1905	Functional homolog of human NPC2/He1; human NPC2 is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 16278452]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032366 - intracellular sterol transport [Evidence IGI,ISS] [PMID 16278452]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1910	GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1914	Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IPI] [PMID 16215987]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 19120453]; GO_function: GO:0043022 - ribosome binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IPI] [PMID 16215987]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IDA,IMP] [PMID 19424157]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 21451136]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IEA]; GO_process: GO:0045901 - positive regulation of translational elongation [Evidence IEA]; GO_process: GO:0045901 - positive regulation of translational elongation [Evidence IGI,IMP] [PMID 19338753]; GO_process: GO:0045901 - positive regulation of translational elongation [Evidence IDA,IMP] [PMID 19424157]; GO_process: GO:0045948 - positive regulation of translational initiation [Evidence IDA] [PMID 21451136]; GO_process: GO:0045905 - positive regulation of translational termination [Evidence IEA]; GO_process: GO:0045905 - positive regulation of translational termination [Evidence IDA] [PMID 19424157]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA]; GO_process: GO:0006452 - translational frameshifting [Evidence IEA]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 19424157]
AWJ20_1915	Nitrogen catabolite repression transcriptional regulator; acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10748041]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IEA]; GO_function: GO:0004602 - glutathione peroxidase activity [Evidence IDA] [PMID 15371425]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0051219 - phosphoprotein binding [Evidence IDA] [PMID 10604478]; GO_function: GO:0003714 - transcription corepressor activity [Evidence IGI,IPI] [PMID 8755910]; GO_process: GO:0042994 - cytoplasmic sequestering of transcription factor [Evidence IMP] [PMID 10748041]; GO_process: GO:0042128 - nitrate assimilation [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IEA]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IMP] [PMID 8002570]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IGI,IPI] [PMID 8755910]; GO_process: GO:0010044 - response to aluminum ion [Evidence IMP] [PMID 15133656]
AWJ20_1916	Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IMP] [PMID 15256563]; GO_process: GO:0006068 - ethanol catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1918	ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity with Glo3p; GCS1 has a paralog, SPS18, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IMP,IPI] [PMID 10069805]; GO_component: GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment [Evidence IPI] [PMID 9927415]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 16452633]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16452633]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IEA]; GO_function: GO:0008060 - ARF GTPase activator activity [Evidence IDA,ISS] [PMID 8816753]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA] [PMID 15975906]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 10069805]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 9927415]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 16926193]; GO_process: GO:0030037 - actin filament reorganization involved in cell cycle [Evidence IGI,IMP,IPI] [PMID 10069805]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032312 - regulation of ARF GTPase activity [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA,IGI,IMP] [PMID 9927415]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1919	Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 20951350]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA,IMP] [PMID 16299494]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA] [PMID 17517611]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IDA] [PMID 17517611]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 15598824]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 16299494]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 17517611]; GO_process: GO:1902660 - negative regulation of glucose mediated signaling pathway [Evidence IMP] [PMID 24277933]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 17517611]; GO_process: GO:0072462 - signal transduction involved in meiotic recombination checkpoint [Evidence IMP] [PMID 20951350]
AWJ20_1920	Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 20951350]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA,IMP] [PMID 16299494]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA] [PMID 17517611]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IDA] [PMID 17517611]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 15598824]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 16299494]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 17517611]; GO_process: GO:1902660 - negative regulation of glucose mediated signaling pathway [Evidence IMP] [PMID 24277933]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 17517611]; GO_process: GO:0072462 - signal transduction involved in meiotic recombination checkpoint [Evidence IMP] [PMID 20951350]
AWJ20_1921	hypothetical protein; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IMP] [PMID 14690608]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IMP] [PMID 12868057]; GO_process: GO:0043486 - histone exchange [Evidence IPI] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1922	Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8307027]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 8307027]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA,IMP,ISS] [PMID 8307027]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IDA,IMP] [PMID 8307027]
AWJ20_1923	Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 11926067]; GO_component: GO:0009353 - mitochondrial oxoglutarate dehydrogenase complex [Evidence IDA] [PMID 2072900]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045252 - oxoglutarate dehydrogenase complex [Evidence IEA]; GO_function: GO:0004149 - dihydrolipoyllysine-residue succinyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004149 - dihydrolipoyllysine-residue succinyltransferase activity [Evidence ISA] [PMID 2115121]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0006103 - 2-oxoglutarate metabolic process [Evidence IMP] [PMID 2115121]; GO_process: GO:0033512 - L-lysine catabolic process to acetyl-CoA via saccharopine [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 10869431]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IC] [PMID 2072900]
AWJ20_1925	Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 16565073]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0000015 - phosphopyruvate hydratase complex [Evidence IEA]; GO_component: GO:0000015 - phosphopyruvate hydratase complex [Evidence IDA] [PMID 6282834]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004634 - phosphopyruvate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0004634 - phosphopyruvate hydratase activity [Evidence IMP] [PMID 6282834]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEP] [PMID 3313003]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 6282834]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IDA,IMP] [PMID 16565073]
AWJ20_1928	similar to Saccharomyces cerevisiae S288c NP_116617.1
AWJ20_1929	hypothetical protein; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8065298]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0019933 - cAMP-mediated signaling [Evidence IGI] [PMID 8065298]
AWJ20_1930	Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10888667]; GO_component: GO:0032580 - Golgi cisterna membrane [Evidence IEA]; GO_component: GO:0070916 - inositol phosphoceramide synthase complex [Evidence IPI] [PMID 19726565]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0045140 - inositol phosphoceramide synthase activity [Evidence IDA] [PMID 19047657]; GO_function: GO:0045140 - inositol phosphoceramide synthase activity [Evidence IMP] [PMID 9092515]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IDA] [PMID 19726565]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 9092515]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
AWJ20_1931	Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16291748]; GO_function: GO:0051724 - NAD transporter activity [Evidence IDA,IGI,IMP] [PMID 16291748]; GO_function: GO:0005477 - pyruvate secondary active transmembrane transporter activity [Evidence IMP] [PMID 12887330]; GO_function: GO:0005477 - pyruvate secondary active transmembrane transporter activity [Evidence IDA] [PMID 16291748]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 10930523]; GO_process: GO:0035352 - NAD transmembrane transport [Evidence IDA,IGI,IMP] [PMID 16291748]; GO_process: GO:0006850 - mitochondrial pyruvate transport [Evidence IMP] [PMID 12887330]; GO_process: GO:0006850 - mitochondrial pyruvate transport [Evidence IDA] [PMID 16291748]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 10930523]
AWJ20_1932	EFW99297|beta-galactosidase [Grosmannia clavigera kw1407]
AWJ20_1933	Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1986247]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 1986247]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 8846888]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 8846888]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:2001158 - positive regulation of proline catabolic process to glutamate [Evidence IMP] [PMID 2689862]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2689862]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8846888]; GO_process: GO:0006560 - proline metabolic process [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 22579222]
AWJ20_1935	Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0030118 - clathrin coat [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence TAS] [PMID 12461563]; GO_function: GO:0005543 - phospholipid binding [Evidence IEA]; GO_process: GO:0048268 - clathrin coat assembly [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IPI,ISS] [PMID 9531549]
AWJ20_1937	Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 3025596]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003842 - 1-pyrroline-5-carboxylate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003842 - 1-pyrroline-5-carboxylate dehydrogenase activity [Evidence IMP] [PMID 387737]; GO_function: GO:0003842 - 1-pyrroline-5-carboxylate dehydrogenase activity [Evidence IDA] [PMID 4145181]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IDA] [PMID 4145181]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IEA]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IEA]; GO_process: GO:0010133 - proline catabolic process to glutamate [Evidence IMP] [PMID 387737]; GO_process: GO:0006560 - proline metabolic process [Evidence IEA]
AWJ20_1939	allele of CaO19.12061
AWJ20_1940	Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 20670889]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 23185031]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_1941	Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISS] [PMID 10760581]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI] [PMID 21076151]
AWJ20_1942	Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10545096]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005476 - carnitine:acyl carnitine antiporter activity [Evidence IDA] [PMID 10545096]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IDA] [PMID 10545096]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1943	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000928 - gamma-tubulin small complex, spindle pole body [Evidence IPI] [PMID 9384578]; GO_component: GO:0005822 - inner plaque of spindle pole body [Evidence IDA] [PMID 9215630]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005815 - microtubule organizing center [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005824 - outer plaque of spindle pole body [Evidence IDA] [PMID 9215630]; GO_component: GO:0000922 - spindle pole [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9215630]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IEA]; GO_process: GO:0007020 - microtubule nucleation [Evidence IEA]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IMP] [PMID 9153752]
AWJ20_1944	Protein localized to COPII vesicles; proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 16002643]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16002643]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]
AWJ20_1945	potential ankyrin repeats near N terminus similar to S. cerevisiae YCR051W; allele of CaO19.2256
AWJ20_1948	Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IEA,IEA]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IMP] [PMID 5345980]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IMP] [PMID 5345980]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006567 - threonine catabolic process [Evidence IGI] [PMID 7042346]
AWJ20_1949	Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17034789]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17034789]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IDA] [PMID 19342587]; GO_function: GO:0004061 - arylformamidase activity [Evidence IDA] [PMID 18205391]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016212 - kynurenine-oxoglutarate transaminase activity [Evidence IEA]; GO_function: GO:0016212 - kynurenine-oxoglutarate transaminase activity [Evidence IDA,ISS] [PMID 18205391]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0097053 - L-kynurenine catabolic process [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0034276 - kynurenic acid biosynthetic process [Evidence IDA,ISS] [PMID 18205391]
AWJ20_1950	Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 21168530]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 21168530]
AWJ20_1951	hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12514182]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1952	Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 3905826]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004615 - phosphomannomutase activity [Evidence IEA,IEA]; GO_function: GO:0004615 - phosphomannomutase activity [Evidence IDA] [PMID 3288631]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IEA]; GO_process: GO:0019307 - mannose biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 6368572]
AWJ20_1954	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 9858605]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15125836]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 2277060]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 8293976]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1957	Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 4355481]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IDA] [PMID 3071718]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IMP] [PMID 6297759]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IMP] [PMID 23642236]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IMP] [PMID 6297759]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_1958	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_1960	Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 19837041]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19720832]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19720832]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IDA,IMP] [PMID 19720832]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IMP] [PMID 19837041]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 19720832]; GO_process: GO:0016485 - protein processing [Evidence IGI,IMP] [PMID 19837041]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 19837041]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_1961	Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8267570]; GO_function: GO:0015212 - cytidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 10501935]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IDA] [PMID 9092500]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015861 - cytidine transport [Evidence IDA,IMP] [PMID 10501935]; GO_process: GO:0015856 - cytosine transport [Evidence IDA] [PMID 9092500]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0072530 - purine-containing compound transmembrane transport [Evidence IDA] [PMID 9092500]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_1965	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_1968	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23222640]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 10072385]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006376 - mRNA splice site selection [Evidence IMP] [PMID 10072385]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]; GO_process: GO:0048026 - positive regulation of mRNA splicing, via spliceosome [Evidence IMP] [PMID 10983980]
AWJ20_1970	High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity [Evidence IDA] [PMID 3025832]; GO_function: GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0019933 - cAMP-mediated signaling [Evidence IMP] [PMID 8391474]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_1971	Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 18469165]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11445562]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20007605]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12858164]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 16429156]; GO_function: GO:0070336 - flap-structured DNA binding [Evidence IDA] [PMID 20007605]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 12858164]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 16429156]; GO_process: GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening [Evidence IMP,IPI] [PMID 18469165]; GO_process: GO:0032079 - positive regulation of endodeoxyribonuclease activity [Evidence IDA,IPI] [PMID 20007605]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1972	Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1); GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA,IMP] [PMID 20007951]; GO_function: GO:0042393 - histone binding [Evidence IDA,IPI] [PMID 16157874]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 18662540]; GO_function: GO:0042393 - histone binding [Evidence IDA,IMP] [PMID 20007951]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IGI] [PMID 18662540]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IMP] [PMID 18708354]; GO_process: GO:0070869 - heterochromatin assembly involved in chromatin silencing [Evidence IGI,IMP] [PMID 17410207]; GO_process: GO:0070869 - heterochromatin assembly involved in chromatin silencing [Evidence IGI] [PMID 20007951]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 19683497]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 18708354]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]
AWJ20_1973	Type 1 serine/threonine protein phosphatase catalytic subunit; cleavage and polyadenylation factor (CPF) component; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11412094]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 19948764]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 10747092]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11412094]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23418575]; GO_component: GO:0000164 - protein phosphatase type 1 complex [Evidence IDA] [PMID 8289829]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 10747092]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 1660885]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 19884341]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IGI,IMP] [PMID 19884341]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 9584086]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007114 - cell budding [Evidence IMP] [PMID 10639337]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 11973298]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 10072383]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 24413056]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IMP] [PMID 1660885]; GO_process: GO:0016576 - histone dephosphorylation [Evidence IMP] [PMID 10975519]; GO_process: GO:0016576 - histone dephosphorylation [Evidence IDA,IMP] [PMID 19884341]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IPI] [PMID 8754819]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IMP] [PMID 10072380]; GO_process: GO:0035307 - positive regulation of protein dephosphorylation [Evidence IMP] [PMID 23418575]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 1660885]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IMP] [PMID 19948764]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0006109 - regulation of carbohydrate metabolic process [Evidence IGI,IPI] [PMID 12167649]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 10072380]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 7891699]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 8164671]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 9584086]; GO_process: GO:0000903 - regulation of cell shape during vegetative growth phase [Evidence IGI] [PMID 12477789]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IMP] [PMID 23418575]; GO_process: GO:0031297 - replication fork processing [Evidence IMP] [PMID 19884341]; GO_process: GO:0009408 - response to heat [Evidence IMP,IPI] [PMID 10207049]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IPI] [PMID 12819204]; GO_process: GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled [Evidence IPI] [PMID 12819204]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
AWJ20_1974	Type 1 serine/threonine protein phosphatase catalytic subunit; cleavage and polyadenylation factor (CPF) component; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11412094]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 19948764]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 10747092]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11412094]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23418575]; GO_component: GO:0000164 - protein phosphatase type 1 complex [Evidence IDA] [PMID 8289829]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 10747092]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 1660885]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 19884341]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IGI,IMP] [PMID 19884341]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 9584086]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007114 - cell budding [Evidence IMP] [PMID 10639337]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 11973298]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 10072383]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 24413056]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IMP] [PMID 1660885]; GO_process: GO:0016576 - histone dephosphorylation [Evidence IMP] [PMID 10975519]; GO_process: GO:0016576 - histone dephosphorylation [Evidence IDA,IMP] [PMID 19884341]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IPI] [PMID 8754819]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IMP] [PMID 10072380]; GO_process: GO:0035307 - positive regulation of protein dephosphorylation [Evidence IMP] [PMID 23418575]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 1660885]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IMP] [PMID 19948764]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0006109 - regulation of carbohydrate metabolic process [Evidence IGI,IPI] [PMID 12167649]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 10072380]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 7891699]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 8164671]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 9584086]; GO_process: GO:0000903 - regulation of cell shape during vegetative growth phase [Evidence IGI] [PMID 12477789]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IMP] [PMID 23418575]; GO_process: GO:0031297 - replication fork processing [Evidence IMP] [PMID 19884341]; GO_process: GO:0009408 - response to heat [Evidence IMP,IPI] [PMID 10207049]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IPI] [PMID 12819204]; GO_process: GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled [Evidence IPI] [PMID 12819204]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
AWJ20_1975	Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16533810]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA] [PMID 16533810]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IDA,IMP] [PMID 21278159]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16533810]; GO_process: GO:0061420 - regulation of transcription from RNA polymerase II promoter in response to biotin starvation [Evidence IMP] [PMID 16533810]; GO_process: GO:0061420 - regulation of transcription from RNA polymerase II promoter in response to biotin starvation [Evidence IMP] [PMID 21278159]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1976	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
AWJ20_1977	Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_1978	Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 20404342]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0044183 - protein binding involved in protein folding [Evidence IMP,IPI] [PMID 22927643]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 21807901]
AWJ20_1980	Mitochondrial elongation factor involved in translational elongation; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 19716793]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 21414316]; GO_process: GO:0032543 - mitochondrial translation [Evidence ISS] [PMID 19716793]; GO_process: GO:0051881 - regulation of mitochondrial membrane potential [Evidence IMP] [PMID 21414316]; GO_process: GO:0032790 - ribosome disassembly [Evidence ISS] [PMID 19716793]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1983	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11011149]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0031491 - nucleosome binding [Evidence IMP] [PMID 16299513]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IMP] [PMID 14690608]; GO_process: GO:0043486 - histone exchange [Evidence IMP] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_1985	Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 12719426]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11864994]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IMP] [PMID 24062159]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IEA]; GO_process: GO:0010032 - meiotic chromosome condensation [Evidence IC] [PMID 10811823]; GO_process: GO:0051307 - meiotic chromosome separation [Evidence IC] [PMID 10811823]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 10811823]; GO_process: GO:0070550 - rDNA condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IC] [PMID 10811823]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
AWJ20_1986	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 9083048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043334 - 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Evidence IMP,ISS] [PMID 9083049]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9083049]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9083048]
AWJ20_1990	Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0080129 - proteasome core complex assembly [Evidence IMP] [PMID 14739934]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_1992	Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12972564]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11854408]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12972564]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 12972564]; GO_process: GO:0007114 - cell budding [Evidence IGI,IMP] [PMID 11854408]; GO_process: GO:0000902 - cell morphogenesis [Evidence IGI,IMP] [PMID 11854408]
AWJ20_1993	Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11932453]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 2686980]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:1990259 - histone-glutamine methyltransferase activity [Evidence IMP] [PMID 24352239]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008649 - rRNA methyltransferase activity [Evidence IDA,IMP] [PMID 12215523]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000494 - box C/D snoRNA 3'-end processing [Evidence IMP] [PMID 10733567]; GO_process: GO:0000494 - box C/D snoRNA 3'-end processing [Evidence IMP] [PMID 15167896]; GO_process: GO:1990258 - histone glutamine methylation [Evidence IDA,IMP] [PMID 24352239]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IDA,IMP] [PMID 12215523]; GO_process: GO:0031167 - rRNA methylation [Evidence IMP] [PMID 8431947]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 1825809]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0043144 - snoRNA processing [Evidence IMP] [PMID 1825809]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_1994	Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_1995	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IGI] [PMID 12429822]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0048193 - Golgi vesicle transport [Evidence IGI] [PMID 12429822]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_1999	Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23222640]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 11410665]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 11410665]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IDA] [PMID 11410665]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 11410665]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0016071 - mRNA metabolic process [Evidence IPI] [PMID 11410665]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 8913743]; GO_process: GO:0007088 - regulation of mitosis [Evidence IMP] [PMID 8913743]
AWJ20_2000	Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IGI,ISS] [PMID 10373490]; GO_function: GO:0015233 - pantothenate transmembrane transporter activity [Evidence IGI,IMP] [PMID 10373490]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 15020461]; GO_process: GO:0015887 - pantothenate transmembrane transport [Evidence IGI,IMP] [PMID 10373490]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2002	Specific translational activator for the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs); GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 18039654]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 9692914]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9692914]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0045182 - translation regulator activity [Evidence IGI] [PMID 7664742]; GO_process: GO:0016070 - RNA metabolic process [Evidence IMP] [PMID 7664742]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 7664742]; GO_process: GO:0097034 - mitochondrial respiratory chain complex IV biogenesis [Evidence IMP] [PMID 7664742]; GO_process: GO:0070134 - positive regulation of mitochondrial translational initiation [Evidence IMP] [PMID 18039654]; GO_process: GO:0070134 - positive regulation of mitochondrial translational initiation [Evidence IMP] [PMID 7664742]
AWJ20_2003	Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005787 - signal peptidase complex [Evidence IEA]; GO_component: GO:0005787 - signal peptidase complex [Evidence IDA] [PMID 1846444]; GO_component: GO:0005787 - signal peptidase complex [Evidence IDA] [PMID 8910564]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IMP] [PMID 9148930]; GO_function: GO:0008233 - peptidase activity [Evidence IMP] [PMID 9148931]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 9148931]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006465 - signal peptide processing [Evidence IEA]; GO_process: GO:0006465 - signal peptide processing [Evidence IMP] [PMID 9148930]; GO_process: GO:0006465 - signal peptide processing [Evidence IDA,IMP] [PMID 9148931]
AWJ20_2004	Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IEA,IEA]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IMP,ISS] [PMID 11031268]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IMP] [PMID 3888627]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11031268]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IEA,IEA]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IEP,IMP,ISS] [PMID 11031268]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 3888627]; GO_process: GO:0006540 - glutamate decarboxylation to succinate [Evidence IGI,IMP,ISS] [PMID 11031268]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2008	Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10783164]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IMP] [PMID 17895243]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 22564307]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:1902450 - negative regulation of ATP-dependent DNA helicase activity [Evidence IDA] [PMID 13679365]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]
AWJ20_2010	Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 20951350]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA,IMP] [PMID 16299494]; GO_component: GO:0030289 - protein phosphatase 4 complex [Evidence IDA] [PMID 17517611]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA,IMP] [PMID 16299494]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 7941742]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IGI] [PMID 21135129]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 16299494]; GO_process: GO:2000002 - negative regulation of DNA damage checkpoint [Evidence IMP] [PMID 17517611]; GO_process: GO:1902660 - negative regulation of glucose mediated signaling pathway [Evidence IMP] [PMID 24277933]; GO_process: GO:0051173 - positive regulation of nitrogen compound metabolic process [Evidence IMP] [PMID 10940301]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA,IMP] [PMID 16299494]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 7941742]; GO_process: GO:0072462 - signal transduction involved in meiotic recombination checkpoint [Evidence IMP] [PMID 20951350]
AWJ20_2011	Membrane hypothetical protein; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 17005914]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI] [PMID 17005914]
AWJ20_2012	Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004427 - inorganic diphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004427 - inorganic diphosphatase activity [Evidence IDA] [PMID 8224193]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IC] [PMID 8224193]
AWJ20_2013	Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004640 - phosphoribosylanthranilate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004640 - phosphoribosylanthranilate isomerase activity [Evidence IDA] [PMID 3286643]; GO_function: GO:0004640 - phosphoribosylanthranilate isomerase activity [Evidence IMP] [PMID 348687]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 10790693]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IDA] [PMID 3286643]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 348687]; GO_process: GO:0006568 - tryptophan metabolic process [Evidence IEA]
AWJ20_2014	Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003725 - double-stranded RNA binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0043047 - single-stranded telomeric DNA binding [Evidence IDA] [PMID 19369944]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 19884342]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 19369944]; GO_process: GO:0070526 - threonylcarbamoyladenosine biosynthetic process [Evidence IDA] [PMID 23620299]; GO_process: GO:0070525 - threonylcarbamoyladenosine metabolic process [Evidence IMP] [PMID 19287007]; GO_process: GO:0070525 - threonylcarbamoyladenosine metabolic process [Evidence IMP] [PMID 21183954]
AWJ20_2015	High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen appears to be required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 24124599]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 9092527]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 10545175]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IEA,IEA]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IDA,IMP] [PMID 10545175]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IMP] [PMID 1379856]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0015410 - manganese-transporting ATPase activity [Evidence IDA] [PMID 10801856]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA,IMP] [PMID 10545175]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI] [PMID 23569283]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 1379856]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006828 - manganese ion transport [Evidence IDA] [PMID 10801856]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2017	Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide; GO_component: GO:0009337 - sulfite reductase complex (NADPH) [Evidence IDA] [PMID 6751400]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016903 - oxidoreductase activity, acting on the aldehyde or oxo group of donors [Evidence IEA]; GO_function: GO:0004783 - sulfite reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0004783 - sulfite reductase (NADPH) activity [Evidence IDA] [PMID 6751400]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 19236486]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 7928966]
AWJ20_2018	GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 12586695]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12586695]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15358789]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 15358789]
AWJ20_2020	Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); mutation of conserved residues leads to defects in endocytic recycling and a block in sporulation/meiosis; mutations in the human homolog cause the spondyloepiphyseal dysplasia; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990070 - TRAPPI protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 9564032]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_2023	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11641273]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11641273]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IEA]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 17051211]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 11641273]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11641273]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
AWJ20_2024	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11641273]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11641273]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IEA]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 17051211]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 11641273]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11641273]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
AWJ20_2025	tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008173 - RNA methyltransferase activity [Evidence IEA]; GO_function: GO:0030697 - S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0051908 - double-stranded DNA 5'-3' exodeoxyribonuclease activity [Evidence IDA] [PMID 17205207]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0000014 - single-stranded DNA endodeoxyribonuclease activity [Evidence IDA] [PMID 17205207]; GO_function: GO:0030696 - tRNA (m5U54) methyltransferase activity [Evidence IDA,IMP] [PMID 10864043]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI,IMP] [PMID 17205207]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI,IMP] [PMID 17534700]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 10864043]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_2031	High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 7616962]; GO_function: GO:0008271 - secondary active sulfate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015116 - sulfate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015116 - sulfate transmembrane transporter activity [Evidence IGI,IMP] [PMID 7616962]; GO_process: GO:1902358 - sulfate transmembrane transport [Evidence IEA]; GO_process: GO:0008272 - sulfate transport [Evidence IEA]; GO_process: GO:0008272 - sulfate transport [Evidence IGI,IMP] [PMID 7616962]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 7616962]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2032	Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 17515604]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IDA] [PMID 17515604]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IDA] [PMID 17515604]
AWJ20_2033	Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence TAS] [PMID 2072919]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015079 - potassium ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015079 - potassium ion transmembrane transporter activity [Evidence IDA,ISS] [PMID 2072919]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0030007 - cellular potassium ion homeostasis [Evidence IDA] [PMID 2072919]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0071805 - potassium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006813 - potassium ion transport [Evidence IEA]; GO_process: GO:0042391 - regulation of membrane potential [Evidence IMP] [PMID 21424545]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2034	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 9920864]; GO_process: GO:1902047 - polyamine transmembrane transport [Evidence IMP] [PMID 24136413]; GO_process: GO:0015847 - putrescine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2036	hypothetical protein; may have a role in lipid metabolism, based on localization to lipid droplets; predicted to be palmitoylated; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_2037	Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 8654361]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 8887673]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA,IMP] [PMID 19759005]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0000774 - adenyl-nucleotide exchange factor activity [Evidence IDA] [PMID 14704430]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP,IPI] [PMID 10409721]; GO_function: GO:0051082 - unfolded protein binding [Evidence IGI,IMP] [PMID 8654361]; GO_function: GO:0051082 - unfolded protein binding [Evidence IGI,IMP] [PMID 8887673]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 8654361]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 8887673]; GO_process: GO:0006986 - response to unfolded protein [Evidence IGI,IMP] [PMID 8654361]; GO_process: GO:0006986 - response to unfolded protein [Evidence IGI,IMP] [PMID 8887673]
AWJ20_2038	Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11015727]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 11921093]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0004070 - aspartate carbamoyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004070 - aspartate carbamoyltransferase activity [Evidence IDA] [PMID 10446140]; GO_function: GO:0004070 - aspartate carbamoyltransferase activity [Evidence IMP] [PMID 4550660]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 5776390]; GO_function: GO:0016743 - carboxyl- or carbamoyltransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0044205 - 'de novo' UMP biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IDA] [PMID 181668]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0070409 - carbamoyl phosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006543 - glutamine catabolic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IDA] [PMID 5651325]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0045984 - negative regulation of pyrimidine nucleobase metabolic process [Evidence IDA] [PMID 5651325]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA]
AWJ20_2040	Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP; GO_component: GO:0030126 - COPI vesicle coat [Evidence IGI,ISS] [PMID 7929113]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 7929113]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP,IPI] [PMID 17101773]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8001155]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
AWJ20_2044	Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 2203793]; GO_function: GO:1901235 - (R)-carnitine transmembrane transporter activity [Evidence IMP] [PMID 23755272]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IMP] [PMID 2203793]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_function: GO:0034228 - ethanolamine transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_process: GO:1900749 - (R)-carnitine transport [Evidence IMP] [PMID 23755272]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015871 - choline transport [Evidence IMP] [PMID 2203793]; GO_process: GO:0015871 - choline transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0034229 - ethanolamine transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0031460 - glycine betaine transport [Evidence IMP] [PMID 16487344]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2046	CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18408053]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18408053]; GO_function: GO:0008420 - CTD phosphatase activity [Evidence IDA] [PMID 19394294]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA,IMP] [PMID 19394294]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI,IMP,IPI] [PMID 18408053]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2048	hypothetical protein; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 10628972]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042149 - cellular response to glucose starvation [Evidence IMP,IPI] [PMID 10628972]
AWJ20_2051	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15210706]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 8970155]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9725905]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 8970155]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:2000728 - regulation of mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 15210706]; GO_process: GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20098417]; GO_process: GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2052	Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO2 has a paralog, IGO1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019208 - phosphatase regulator activity [Evidence IMP] [PMID 23861665]; GO_process: GO:0048255 - mRNA stabilization [Evidence IGI] [PMID 20471941]
AWJ20_2053	Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2055	Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 11038182]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 16968746]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 16186251]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042802 - identical protein binding [Evidence IDA] [PMID 16186251]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 16186251]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 18298044]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP] [PMID 10559943]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI] [PMID 17336903]; GO_process: GO:0051646 - mitochondrion localization [Evidence IGI] [PMID 23341591]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 9786946]; GO_process: GO:0016559 - peroxisome fission [Evidence IGI] [PMID 18445678]; GO_process: GO:0007031 - peroxisome organization [Evidence IGI,IMP] [PMID 16968746]; GO_process: GO:0051260 - protein homooligomerization [Evidence IDA] [PMID 16186251]
AWJ20_2056	hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2058	Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9207060]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 9312134]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
AWJ20_2061	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IEA]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IDA] [PMID 9015380]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA] [PMID 9015380]; GO_process: GO:0018279 - protein N-linked glycosylation via asparagine [Evidence IPI] [PMID 9988747]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
AWJ20_2064	Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8164662]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 8164662]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 9153234]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IDA] [PMID 8164662]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2067	Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8603912]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IPI] [PMID 9657146]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IDA] [PMID 19362171]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence ISS] [PMID 1988444]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IDA] [PMID 9813082]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0045454 - cell redox homeostasis [Evidence TAS] [PMID 11169096]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence ISS] [PMID 1988444]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006662 - glycerol ether metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0080058 - protein deglutathionylation [Evidence IDA,IGI] [PMID 20074363]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA] [PMID 9813082]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 9657146]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 8603912]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 9015301]
AWJ20_2071	Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004834 - tryptophan synthase activity [Evidence IEA,IEA]; GO_function: GO:0004834 - tryptophan synthase activity [Evidence IDA] [PMID 391563]; GO_function: GO:0004834 - tryptophan synthase activity [Evidence ISO] [PMID 6276387]; GO_function: GO:0004834 - tryptophan synthase activity [Evidence IDA] [PMID 6342605]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 10790693]; GO_process: GO:0006568 - tryptophan metabolic process [Evidence IEA]
AWJ20_2073	Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8576053]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004573 - mannosyl-oligosaccharide glucosidase activity [Evidence IEA,IEA]; GO_function: GO:0004573 - mannosyl-oligosaccharide glucosidase activity [Evidence IDA] [PMID 14680956]; GO_function: GO:0004573 - mannosyl-oligosaccharide glucosidase activity [Evidence IMP,ISS] [PMID 9430631]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IMP] [PMID 9430631]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009311 - oligosaccharide metabolic process [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 9363442]
AWJ20_2074	Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication; GO_component: GO:0071627 - integral component of fungal-type vacuolar membrane [Evidence IDA] [PMID 23169667]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015326 - cationic amino acid transmembrane transporter activity [Evidence IMP,ISA] [PMID 23169667]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0034488 - basic amino acid transmembrane export from vacuole [Evidence IMP,ISA] [PMID 23169667]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2075	Ribosomal 60S subunit protein L8B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA,IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000470 - maturation of LSU-rRNA [Evidence IMP] [PMID 22893726]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2076	similar to Pantoea sp. aB, conserved hypothetical protein (NCBI: ZP_07377486.1)
AWJ20_2078	Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2079	Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA,IEA]; GO_component: GO:0000796 - condensin complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003680 - AT DNA binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 12719426]; GO_function: GO:0000217 - DNA secondary structure binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16055730]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IEA]; GO_process: GO:0010032 - meiotic chromosome condensation [Evidence IC] [PMID 10811823]; GO_process: GO:0051307 - meiotic chromosome separation [Evidence IC] [PMID 10811823]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 10811823]; GO_process: GO:0070550 - rDNA condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IC] [PMID 10811823]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
AWJ20_2080	Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IMP] [PMID 8288589]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8288589]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IMP] [PMID 8288589]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2084	Methionyl-tRNA formyltransferase; catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 5277072]; GO_function: GO:0016742 - hydroxymethyl-, formyl- and related transferase activity [Evidence IEA]; GO_function: GO:0004479 - methionyl-tRNA formyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004479 - methionyl-tRNA formyltransferase activity [Evidence IMP] [PMID 10781559]; GO_function: GO:0004479 - methionyl-tRNA formyltransferase activity [Evidence IDA] [PMID 12549912]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0071951 - conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [Evidence IEA]; GO_process: GO:0071951 - conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [Evidence IMP] [PMID 10781559]; GO_process: GO:0071951 - conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [Evidence IDA] [PMID 12549912]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
AWJ20_2088	ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 8146662]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 8276800]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IBA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 8146662]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 8276800]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0070361 - mitochondrial light strand promoter anti-sense binding [Evidence IBA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IBA]; GO_function: GO:0003727 - single-stranded RNA binding [Evidence IBA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IBA,IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IGI] [PMID 8810243]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IEA,IEA]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 16336126]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IGI,IMP] [PMID 7957078]; GO_process: GO:0007005 - mitochondrion organization [Evidence IBA]; GO_process: GO:0070407 - oxidation-dependent protein catabolic process [Evidence IBA,IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0051260 - protein homooligomerization [Evidence IBA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0090296 - regulation of mitochondrial DNA replication [Evidence IEA]; GO_process: GO:0001666 - response to hypoxia [Evidence IBA]
AWJ20_2090	Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 17178117]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IPI] [PMID 11943201]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_2091	Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11427713]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11781332]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20035756]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005227 - calcium activated cation channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005262 - calcium channel activity [Evidence IEA]; GO_function: GO:0005262 - calcium channel activity [Evidence IDA] [PMID 11781332]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005267 - potassium channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005272 - sodium channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005244 - voltage-gated ion channel activity [Evidence IDA] [PMID 1700419]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IDA,IMP] [PMID 11427713]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IDA,IMP] [PMID 11781332]; GO_process: GO:0006811 - ion transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2092	Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IPI] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0004174 - electron-transferring-flavoprotein dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2093	Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog, NMA2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000309 - nicotinamide-nucleotide adenylyltransferase activity [Evidence IEA]; GO_function: GO:0000309 - nicotinamide-nucleotide adenylyltransferase activity [Evidence IDA] [PMID 10428462]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IDA] [PMID 10428462]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]
AWJ20_2095	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; GO_component: GO:0031251 - PAN complex [Evidence IDA] [PMID 8816488]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0004535 - poly(A)-specific ribonuclease activity [Evidence IEA]; GO_function: GO:0004535 - poly(A)-specific ribonuclease activity [Evidence IMP] [PMID 8550599]; GO_process: GO:0090503 - RNA phosphodiester bond hydrolysis, exonucleolytic [Evidence IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP,IPI] [PMID 8550599]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IMP,IPI] [PMID 8550599]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IPI] [PMID 11953437]
AWJ20_2097	Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IBA]; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 2184310]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004357 - glutamate-cysteine ligase activity [Evidence IEA,IEA]; GO_function: GO:0004357 - glutamate-cysteine ligase activity [Evidence IDA] [PMID 1687097]; GO_function: GO:0004357 - glutamate-cysteine ligase activity [Evidence IMP] [PMID 2184310]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IDA] [PMID 1687097]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IMP] [PMID 8768524]; GO_process: GO:0046686 - response to cadmium ion [Evidence IDA] [PMID 10921921]; GO_process: GO:0042542 - response to hydrogen peroxide [Evidence IMP] [PMID 7615092]
AWJ20_2098	Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9427760]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9427760]; GO_function: GO:0001103 - RNA polymerase II repressing transcription factor binding [Evidence IPI] [PMID 18708352]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IC] [PMID 18708352]; GO_function: GO:0001133 - sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IC] [PMID 9427760]; GO_process: GO:0035955 - negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10850718]; GO_process: GO:0035955 - negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17005992]; GO_process: GO:0035955 - negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 18708352]; GO_process: GO:0035955 - negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9427760]; GO_process: GO:0035952 - negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17005992]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]
AWJ20_2099	Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16314178]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12086626]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008134 - transcription factor binding [Evidence IDA] [PMID 12086626]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0061188 - negative regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 16286008]; GO_process: GO:0061186 - negative regulation of chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16286008]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IMP] [PMID 12086626]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 19417103]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2101	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 14736892]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 14736892]; GO_component: GO:0000306 - extrinsic component of vacuolar membrane [Evidence IDA] [PMID 14736892]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 17560372]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 14736892]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 14736892]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IGI] [PMID 10931309]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 14736892]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 17298473]
AWJ20_2102	Protein of the Sec1p/Munc-18 family; essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 7720726]; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9624182]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 7720726]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0000149 - SNARE binding [Evidence IPI] [PMID 16769821]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP,IPI] [PMID 11432826]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 10545112]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI] [PMID 9335586]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 7720726]; GO_process: GO:0048210 - Golgi vesicle fusion to target membrane [Evidence IMP] [PMID 9650782]; GO_process: GO:0035543 - positive regulation of SNARE complex assembly [Evidence IMP] [PMID 11432826]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 7628704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 7628704]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 1493335]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 9650782]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_2103	Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif; GO_component: GO:0000243 - commitment complex [Evidence IDA] [PMID 8682299]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005846 - nuclear cap binding complex [Evidence IEA]; GO_component: GO:0005846 - nuclear cap binding complex [Evidence IDA] [PMID 8811086]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0000339 - RNA cap binding [Evidence IEA]; GO_function: GO:0000339 - RNA cap binding [Evidence IDA,ISS] [PMID 8682299]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0045292 - mRNA cis splicing, via spliceosome [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 8682299]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2104	Cytosolic J-domain-containing protein; required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9679141]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 9679141]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 9679141]
AWJ20_2107	Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 9032248]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence ISA] [PMID 8212900]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IPI] [PMID 9032248]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]
AWJ20_2108	Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IDA] [PMID 19342587]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]
AWJ20_2109	Kinesin-related antiparallel sliding motor protein involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; also inhibits spindle elongation and promotes spindle disassembly in late anaphase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 9693366]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IDA] [PMID 9693366]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906145]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906148]; GO_function: GO:0070463 - tubulin-dependent ATPase activity [Evidence IDA] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IMP] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 23851487]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 9813090]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IGI,IMP] [PMID 10525539]; GO_process: GO:0031115 - negative regulation of microtubule polymerization [Evidence IMP] [PMID 24616221]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 9693366]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906145]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906148]; GO_process: GO:0032888 - regulation of mitotic spindle elongation [Evidence IMP] [PMID 24616221]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 23851487]
AWJ20_2110	Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier proteins into the inner membrane; acts as a voltage-gated ion channel, activated by substrate peptides; interacts with mitochondrial ribosomes; conserved from bacteria to animals; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030061 - mitochondrial crista [Evidence IDA] [PMID 22513091]; GO_component: GO:0097002 - mitochondrial inner boundary membrane [Evidence IDA] [PMID 22513091]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 14657017]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 19783770]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005216 - ion channel activity [Evidence IDA] [PMID 22829595]; GO_function: GO:0032977 - membrane insertase activity [Evidence IMP] [PMID 9285818]; GO_function: GO:0032977 - membrane insertase activity [Evidence IMP] [PMID 9428747]; GO_function: GO:0097177 - mitochondrial ribosome binding [Evidence IDA] [PMID 14657018]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI,IMP] [PMID 18826960]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP] [PMID 17344477]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IMP] [PMID 22846909]; GO_process: GO:0051205 - protein insertion into membrane [Evidence IEA]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 17452441]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 9285818]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP] [PMID 9428747]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP,IPI] [PMID 9482871]
AWJ20_2111	Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 12135984]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016298 - lipase activity [Evidence IDA] [PMID 18199283]; GO_function: GO:0016298 - lipase activity [Evidence ISS] [PMID 9200815]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA] [PMID 24187129]; GO_process: GO:0007031 - peroxisome organization [Evidence IEP] [PMID 12135984]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI] [PMID 24187129]
AWJ20_2112	One of three possible beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain; GAL83 has a paralog, SIP2, that arose from the whole genome duplication; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA] [PMID 12393914]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IPI] [PMID 7813428]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IPI] [PMID 9121458]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17237508]; GO_component: GO:0005641 - nuclear envelope lumen [Evidence IDA] [PMID 17237508]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11331606]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17237508]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IGI] [PMID 10990457]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 7813428]; GO_process: GO:0007155 - cell adhesion [Evidence IMP] [PMID 12556493]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12556493]; GO_process: GO:0006468 - protein phosphorylation [Evidence IGI] [PMID 10990457]; GO_process: GO:0043254 - regulation of protein complex assembly [Evidence IGI] [PMID 9121458]; GO_process: GO:0007165 - signal transduction [Evidence IGI] [PMID 10990457]
AWJ20_2113	Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 17914457]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17914457]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17914457]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 17914457]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 17914457]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17914457]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 7962098]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 7579704]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IC] [PMID 7579704]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI,IMP] [PMID 17914457]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IEA]; GO_process: GO:0051056 - regulation of small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_2116	Putative acyltransferase with similarity to Eeb1p and Eht1p; has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence ISS] [PMID 16361250]; GO_process: GO:0051792 - medium-chain fatty acid biosynthetic process [Evidence IGI] [PMID 16361250]
AWJ20_2117	Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9874242]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003878 - ATP citrate synthase activity [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IEA,IEA]; GO_function: GO:0004775 - succinate-CoA ligase (ADP-forming) activity [Evidence IDA,IMP,ISS] [PMID 9874242]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006104 - succinyl-CoA metabolic process [Evidence IDA] [PMID 9874242]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
AWJ20_2118	Putative GTP binding protein; negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD; GO_component: GO:0034448 - EGO complex [Evidence IPI] [PMID 15989961]; GO_component: GO:0034448 - EGO complex [Evidence IDA] [PMID 16732272]; GO_component: GO:1990131 - Gtr1-Gtr2 GTPase complex [Evidence IPI] [PMID 10388807]; GO_component: GO:1990131 - Gtr1-Gtr2 GTPase complex [Evidence IPI] [PMID 16143306]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10388807]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11073942]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15989961]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031902 - late endosome membrane [Evidence IDA] [PMID 16732272]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 18258182]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10388807]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11073942]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISA] [PMID 10388807]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0016237 - microautophagy [Evidence IMP] [PMID 15989961]; GO_process: GO:0032008 - positive regulation of TOR signaling [Evidence IGI,IMP] [PMID 19748353]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 18258182]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2119	tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IDA,IMP] [PMID 16642040]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 16642040]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16642040]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 17150819]
AWJ20_2120	Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16113655]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16113655]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12888345]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004815 - aspartate-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004815 - aspartate-tRNA ligase activity [Evidence IDA] [PMID 8263943]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006422 - aspartyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006422 - aspartyl-tRNA aminoacylation [Evidence IDA] [PMID 8263943]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2124	Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9295278]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11500508]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18977757]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0016532 - superoxide dismutase copper chaperone activity [Evidence IGI,IMP,ISS] [PMID 9295278]; GO_function: GO:0008270 - zinc ion binding [Evidence IBA]; GO_process: GO:0015680 - intracellular copper ion transport [Evidence IMP,ISS] [PMID 9295278]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0019430 - removal of superoxide radicals [Evidence IBA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IEA]
AWJ20_2125	Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15077113]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9880327]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 16926193]; GO_process: GO:0000042 - protein targeting to Golgi [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 9880327]
AWJ20_2126	Chitin deacetylase; together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall; GO_component: GO:0005631 - chitosan layer of spore wall [Evidence ISS] [PMID 8940152]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004099 - chitin deacetylase activity [Evidence IEA]; GO_function: GO:0004099 - chitin deacetylase activity [Evidence IDA,ISS] [PMID 8940152]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA,IMP] [PMID 8940152]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2127	NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0047816 - D-arabinose 1-dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0045290 - D-arabinose 1-dehydrogenase [NAD(P)+] activity [Evidence IDA,IMP] [PMID 17097644]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0070485 - dehydro-D-arabinono-1,4-lactone biosynthetic process [Evidence IMP] [PMID 17097644]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2131	Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IMP] [PMID 21347278]
AWJ20_2132	Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 19882662]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346238]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346239]; GO_component: GO:0031461 - cullin-RING ubiquitin ligase complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IPI] [PMID 16421250]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP,IPI] [PMID 9499404]; GO_function: GO:0061630 - ubiquitin protein ligase activity [Evidence IDA] [PMID 9346238]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 10385629]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 9346239]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 8943317]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 7954792]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 9736614]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_2133	Meiosis-specific protein required for spore wall formation; localizes to prospore membrane (PSM) and is required for PSM closure during sporulation; mediates PSM size; interacts with Spo1p and Vps13p and recruits Vps13p to the PSM during sporulation; mutants exhibit reduction in PSM PtdIns-phosphate pools; dispensable for both nuclear divisions during meiosis; contains two PH domains; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24036347]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 22611022]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IEP,IMP] [PMID 9784122]; GO_process: GO:1902657 - protein localization to prospore membrane [Evidence IDA] [PMID 24036347]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2134	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005753 - mitochondrial proton-transporting ATP synthase complex [Evidence IDA] [PMID 10066811]; GO_component: GO:0000274 - mitochondrial proton-transporting ATP synthase, stator stalk [Evidence IMP,ISS] [PMID 2146269]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP] [PMID 7866306]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP] [PMID 15254373]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,ISS] [PMID 2146269]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2135	Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9445368]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9445368]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 9079633]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2136	Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_2137	Putative cysteine synthase; localized to the mitochondrial outer membrane; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004124 - cysteine synthase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006535 - cysteine biosynthetic process from serine [Evidence IEA]
AWJ20_2139	Member of the NineTeen Complex (NTC); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; relocalizes to the cytosol in response to hypoxia; homologs in human and C. elegans; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 11842115]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11842115]; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0071008 - U2-type post-mRNA release spliceosomal complex [Evidence IDA] [PMID 11105756]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 11105756]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 11842115]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IC] [PMID 11105756]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IDA] [PMID 19617314]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_2140	Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 1400574]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IDA] [PMID 3882418]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence ISS] [PMID 2651436]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence ISS] [PMID 2689224]
AWJ20_2141	Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 12206772]; GO_component: GO:0005643 - nuclear pore [Evidence IDA,IGI] [PMID 12411502]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11139493]; GO_component: GO:0070390 - transcription export complex 2 [Evidence IDA] [PMID 15311284]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12702719]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 12702719]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 12411502]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0071033 - nuclear retention of pre-mRNA at the site of transcription [Evidence IMP] [PMID 18003937]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 18003937]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 11139493]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2144	Type 2A-related serine-threonine phosphatase; functions in the G1/S transition of the mitotic cycle; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 1848673]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IMP] [PMID 23864707]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15150670]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 1848673]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 15367655]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 12080055]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 18357452]; GO_process: GO:0016311 - dephosphorylation [Evidence IMP] [PMID 15367655]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 12080055]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IMP] [PMID 12080055]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 15843932]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_2145	Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 12135984]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016298 - lipase activity [Evidence IDA] [PMID 18199283]; GO_function: GO:0016298 - lipase activity [Evidence ISS] [PMID 9200815]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA] [PMID 24187129]; GO_process: GO:0007031 - peroxisome organization [Evidence IEP] [PMID 12135984]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI] [PMID 24187129]
AWJ20_2149	ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; GPI stands for glycosylphosphatidylinositol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence ISS] [PMID 10085243]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000225 - N-acetylglucosaminylphosphatidylinositol deacetylase activity [Evidence IEA]; GO_function: GO:0000225 - N-acetylglucosaminylphosphatidylinositol deacetylase activity [Evidence ISS] [PMID 10085243]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence ISS] [PMID 10085243]
AWJ20_2151	Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication; GO_component: GO:0022626 - cytosolic ribosome [Evidence IPI] [PMID 9544245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9544245]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IGI,ISS] [PMID 9544245]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA]; GO_process: GO:0006414 - translational elongation [Evidence IGI] [PMID 9544245]
AWJ20_2155	Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 8314797]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20681974]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI,IMP] [PMID 20681974]; GO_process: GO:0016197 - endosomal transport [Evidence IMP] [PMID 20526336]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 18178563]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 18178563]; GO_process: GO:0007034 - vacuolar transport [Evidence IGI] [PMID 20526336]
AWJ20_2156	Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 8314797]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20681974]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI,IMP] [PMID 20681974]; GO_process: GO:0016197 - endosomal transport [Evidence IMP] [PMID 20526336]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 18178563]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 18178563]; GO_process: GO:0007034 - vacuolar transport [Evidence IGI] [PMID 20526336]
AWJ20_2157	Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 2138512]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000922 - spindle pole [Evidence IDA] [PMID 14562095]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 11729143]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 2138512]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 8106549]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 22734002]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0008569 - minus-end-directed microtubule motor activity [Evidence IDA] [PMID 8041770]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16107877]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IMP] [PMID 2138512]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IDA,IMP] [PMID 11729143]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IGI] [PMID 9201713]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 16380440]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 2138512]
AWJ20_2158	Nucleolar protein; constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 15769876]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15769876]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15769876]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2159	Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10375636]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016653 - oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Evidence IGI,IMP] [PMID 11788607]; GO_process: GO:0006784 - heme a biosynthetic process [Evidence IGI,IMP] [PMID 11788607]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12970193]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 20534343]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 21944752]
AWJ20_2160	Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8045256]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12374868]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 7679674]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 7679674]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 11389139]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 8626301]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0000770 - peptide pheromone export [Evidence IMP] [PMID 2569166]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2161	Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid methyltransferase; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 2445736]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008170 - N-methyltransferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0080101 - phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0080101 - phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [Evidence IDA,IGI] [PMID 2445736]; GO_function: GO:0080101 - phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [Evidence IMP] [PMID 2684666]; GO_function: GO:0000773 - phosphatidyl-N-methylethanolamine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0000773 - phosphatidyl-N-methylethanolamine N-methyltransferase activity [Evidence IDA,IGI] [PMID 2445736]; GO_function: GO:0000773 - phosphatidyl-N-methylethanolamine N-methyltransferase activity [Evidence IMP] [PMID 2684666]; GO_function: GO:0004608 - phosphatidylethanolamine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 23000174]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA,IGI] [PMID 2445736]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 6337128]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IEA]
AWJ20_2162	Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8164662]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 8164662]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 7814363]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IDA] [PMID 8164662]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2163	Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2165	Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA,IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 15485916]
AWJ20_2166	Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 12228251]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 19426738]; GO_process: GO:0000493 - box H/ACA snoRNP assembly [Evidence IMP,IPI] [PMID 12228251]
AWJ20_2169	Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IDA] [PMID 12589066]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 15090616]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI] [PMID 15090616]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI] [PMID 16195350]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 16195350]; GO_process: GO:0006886 - intracellular protein transport [Evidence IMP] [PMID 16956384]; GO_process: GO:0045332 - phospholipid translocation [Evidence IGI] [PMID 15090616]
AWJ20_2170	Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-associated endoplasmic reticulum, and the mitochondrial outer membrane; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11298754]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9450962]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003838 - sterol 24-C-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003838 - sterol 24-C-methyltransferase activity [Evidence IDA] [PMID 18563465]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 2677674]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 6363386]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
AWJ20_2172	Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015183 - L-aspartate transmembrane transporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0005313 - L-glutamate transmembrane transporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0015297 - antiporter activity [Evidence IDA] [PMID 14622413]; GO_function: GO:0015292 - uniporter activity [Evidence IDA] [PMID 14622413]; GO_process: GO:0015813 - L-glutamate transport [Evidence IDA] [PMID 14622413]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015810 - aspartate transport [Evidence IDA] [PMID 14622413]; GO_process: GO:0044271 - cellular nitrogen compound biosynthetic process [Evidence IMP] [PMID 14622413]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2173	Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 8670886]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IEA]; GO_function: GO:0004467 - long-chain fatty acid-CoA ligase activity [Evidence IDA] [PMID 8206942]; GO_function: GO:0031956 - medium-chain fatty acid-CoA ligase activity [Evidence IDA] [PMID 8206942]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0031957 - very long-chain fatty acid-CoA ligase activity [Evidence IGI] [PMID 9988704]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0001676 - long-chain fatty acid metabolic process [Evidence IGI,IMP] [PMID 7962057]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2174	High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3169249]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 7721780]; GO_function: GO:0031491 - nucleosome binding [Evidence ISS] [PMID 11432837]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0070898 - RNA polymerase III transcriptional preinitiation complex assembly [Evidence IGI] [PMID 11287614]; GO_process: GO:0070898 - RNA polymerase III transcriptional preinitiation complex assembly [Evidence IDA] [PMID 17178828]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI] [PMID 14739928]; GO_process: GO:0001195 - maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter [Evidence IDA] [PMID 16407207]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI] [PMID 8946917]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2175	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
AWJ20_2176	Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2177	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IGI,IMP] [PMID 8415737]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IGI,IMP] [PMID 8950190]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2178	Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 11105764]; GO_process: GO:0000154 - rRNA modification [Evidence TAS] [PMID 10690410]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2181	Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IEA]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IDA] [PMID 8135547]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IEA]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IMP] [PMID 11827175]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IPI] [PMID 8135547]; GO_function: GO:0030291 - protein serine/threonine kinase inhibitor activity [Evidence IDA] [PMID 18265947]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 11551505]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 16607517]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16952051]; GO_process: GO:0045859 - regulation of protein kinase activity [Evidence IEA]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IDA] [PMID 11551505]; GO_process: GO:0006359 - regulation of transcription from RNA polymerase III promoter [Evidence IDA] [PMID 11551505]
AWJ20_2182	Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11278728]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051087 - chaperone binding [Evidence IEA]; GO_function: GO:0051087 - chaperone binding [Evidence IMP] [PMID 11278728]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 9813017]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 9813017]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 11278728]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0051259 - protein oligomerization [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_2185	hypothetical protein; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 16582425]
AWJ20_2187	RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15520468]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 16537912]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2685562]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2190	Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; GO_component: GO:0031416 - NatB complex [Evidence IDA] [PMID 12783868]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IMP,ISS] [PMID 10545125]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0017196 - N-terminal peptidyl-methionine acetylation [Evidence IMP] [PMID 10545125]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IGI,IMP] [PMID 12808144]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IGI,IMP] [PMID 12808144]
AWJ20_2192	Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7629121]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7629121]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008641 - small protein activating enzyme activity [Evidence IEA]; GO_function: GO:0004839 - ubiquitin activating enzyme activity [Evidence IDA] [PMID 1989885]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 1989885]
AWJ20_2197	allele of CaO19.8194
AWJ20_2199	Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8798704]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0052656 - L-isoleucine transaminase activity [Evidence IEA]; GO_function: GO:0052654 - L-leucine transaminase activity [Evidence IEA]; GO_function: GO:0052655 - L-valine transaminase activity [Evidence IEA]; GO_function: GO:0004084 - branched-chain-amino-acid transaminase activity [Evidence IEA,IEA]; GO_function: GO:0004084 - branched-chain-amino-acid transaminase activity [Evidence IDA] [PMID 8798704]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IDA,IMP] [PMID 8798704]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IMP] [PMID 8702755]; GO_process: GO:0009081 - branched-chain amino acid metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
AWJ20_2200	NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0032440 - 2-alkenal reductase [NAD(P)] activity [Evidence IDA] [PMID 21276778]; GO_function: GO:0017091 - AU-rich element binding [Evidence IDA] [PMID 17497241]; GO_function: GO:0017091 - AU-rich element binding [Evidence IDA] [PMID 19007762]; GO_function: GO:0003960 - NADPH:quinone reductase activity [Evidence IEA]; GO_function: GO:0003960 - NADPH:quinone reductase activity [Evidence IDA] [PMID 17497241]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17497241]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2204	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_2205	similar to several putative epoxide hydrolases; has match to alpha/beta hydrolase fold; allele of CaO19.6709
AWJ20_2206	GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2207	GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2208	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15210706]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 8970155]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 9725905]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 8970155]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:2000728 - regulation of mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 15210706]; GO_process: GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20098417]; GO_process: GO:0000972 - transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2209	Protein required for fermentation at low temperature; plays a role in the maturation of secretory proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006113 - fermentation [Evidence IMP] [PMID 10781556]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 19433630]
AWJ20_2210	Protein required for fermentation at low temperature; plays a role in the maturation of secretory proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006113 - fermentation [Evidence IMP] [PMID 10781556]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 19433630]
AWJ20_2211	GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 23878277]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 9038344]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI] [PMID 9038344]; GO_process: GO:0090038 - negative regulation of protein kinase C signaling [Evidence IMP] [PMID 10625705]; GO_process: GO:0090038 - negative regulation of protein kinase C signaling [Evidence IGI] [PMID 11713681]; GO_process: GO:0090038 - negative regulation of protein kinase C signaling [Evidence IMP] [PMID 12207708]; GO_process: GO:0032321 - positive regulation of Rho GTPase activity [Evidence IDA] [PMID 9038344]; GO_process: GO:0032956 - regulation of actin cytoskeleton organization [Evidence IGI] [PMID 2183030]; GO_process: GO:0032956 - regulation of actin cytoskeleton organization [Evidence IGI] [PMID 9038344]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 10625705]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI] [PMID 12949174]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_2212	Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10393809]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 16239147]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 10393809]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0008092 - cytoskeletal protein binding [Evidence IPI,ISS] [PMID 10388809]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20610658]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 8590801]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20610658]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IPI] [PMID 15802519]
AWJ20_2213	Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 17652137]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17652137]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 17652137]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2216	One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 11916983]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8978672]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 11916983]; GO_function: GO:0008289 - lipid binding [Evidence IDA,IMP] [PMID 20008566]; GO_function: GO:0008142 - oxysterol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0008142 - oxysterol binding [Evidence IMP,IPI] [PMID 16136145]; GO_function: GO:0070300 - phosphatidic acid binding [Evidence IDA] [PMID 20729555]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IMP,IPI] [PMID 11916983]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA] [PMID 20729555]; GO_function: GO:0015248 - sterol transporter activity [Evidence IDA,IMP] [PMID 20008566]; GO_process: GO:0035621 - ER to Golgi ceramide transport [Evidence IMP] [PMID 24213531]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 15173322]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17004323]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IGI] [PMID 17004323]; GO_process: GO:0010922 - positive regulation of phosphatase activity [Evidence IDA] [PMID 21295699]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IGI] [PMID 11916983]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IGI] [PMID 8978672]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]; GO_process: GO:0015918 - sterol transport [Evidence IDA,IGI] [PMID 16585271]; GO_process: GO:0015918 - sterol transport [Evidence IDA,IMP] [PMID 20008566]
AWJ20_2217	High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3169249]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 7721780]; GO_function: GO:0031491 - nucleosome binding [Evidence ISS] [PMID 11432837]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0070898 - RNA polymerase III transcriptional preinitiation complex assembly [Evidence IGI] [PMID 11287614]; GO_process: GO:0070898 - RNA polymerase III transcriptional preinitiation complex assembly [Evidence IDA] [PMID 17178828]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI] [PMID 14739928]; GO_process: GO:0001195 - maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter [Evidence IDA] [PMID 16407207]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI] [PMID 8946917]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2218	Deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 8982460]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 12914939]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence TAS] [PMID 8982460]; GO_process: GO:0016579 - protein deubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_2219	potential heme/steroid binding protein; similar to A. thaliana F17I14_130; allele of CaO19.4522
AWJ20_2221	Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader; GO_component: GO:0005951 - carbamoyl-phosphate synthase complex [Evidence IDA] [PMID 206535]; GO_component: GO:0005951 - carbamoyl-phosphate synthase complex [Evidence ISS] [PMID 6086650]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IMP] [PMID 6086650]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 8626695]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IMP] [PMID 9290206]; GO_process: GO:0070409 - carbamoyl phosphate biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006543 - glutamine catabolic process [Evidence IEA]
AWJ20_2222	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence ISS] [PMID 12003496]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IMP] [PMID 14970222]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0002943 - tRNA dihydrouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence ISS] [PMID 12003496]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 14970222]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_2225	Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030692 - Noc4p-Nop14p complex [Evidence IPI] [PMID 12446671]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11694595]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 11694595]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2227	Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23637464]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19244244]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004623 - phospholipase A2 activity [Evidence IDA,IMP] [PMID 19244244]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 19244244]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 23637464]; GO_process: GO:0032048 - cardiolipin metabolic process [Evidence IDA,IGI] [PMID 19244244]
AWJ20_2228	NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 18630881]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_function: GO:0031132 - serine 3-dehydrogenase activity [Evidence IDA] [PMID 12535615]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IC] [PMID 12535615]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2229	NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 18630881]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_function: GO:0031132 - serine 3-dehydrogenase activity [Evidence IDA] [PMID 12535615]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IC] [PMID 12535615]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2231	hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_2233	Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_2234	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2236	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 3004948]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IDA] [PMID 3004948]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006089 - lactate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2238	Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 11566870]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0000295 - adenine nucleotide transmembrane transporter activity [Evidence IMP] [PMID 11390660]; GO_function: GO:0000295 - adenine nucleotide transmembrane transporter activity [Evidence IDA] [PMID 11566870]; GO_process: GO:0015867 - ATP transport [Evidence IDA] [PMID 11566870]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IGI,IMP] [PMID 11390660]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IGI,IMP] [PMID 11566870]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IMP] [PMID 11390660]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2240	Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IEA,IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IMP,ISS] [PMID 1551398]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA,IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence TAS] [PMID 11092862]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
AWJ20_2244	High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2246	Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16135531]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 16880272]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16880272]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15304507]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15588229]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IEA]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IMP] [PMID 15588229]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0035965 - cardiolipin acyl-chain remodeling [Evidence IMP] [PMID 14651618]; GO_process: GO:0032048 - cardiolipin metabolic process [Evidence IMP] [PMID 14651618]; GO_process: GO:0007007 - inner mitochondrial membrane organization [Evidence IMP] [PMID 14651618]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042775 - mitochondrial ATP synthesis coupled electron transport [Evidence IMP] [PMID 15304507]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 14651618]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 15588229]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 16135531]
AWJ20_2247	Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions; GO_component: GO:0005671 - Ada2/Gcn5/Ada3 transcription activator complex [Evidence IDA,IPI] [PMID 9154821]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0070461 - SAGA-type complex [Evidence IEA]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IMP] [PMID 10048020]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IMP,IPI] [PMID 9154821]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9154821]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2248	Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions; GO_component: GO:0005671 - Ada2/Gcn5/Ada3 transcription activator complex [Evidence IDA,IPI] [PMID 9154821]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0070461 - SAGA-type complex [Evidence IEA]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IMP] [PMID 10048020]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IMP,IPI] [PMID 9154821]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9154821]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2251	Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance; GO_component: GO:0000790 - nuclear chromatin [Evidence IC] [PMID 10446242]; GO_component: GO:0000790 - nuclear chromatin [Evidence IC] [PMID 10487921]; GO_component: GO:0000790 - nuclear chromatin [Evidence IC] [PMID 7565763]; GO_component: GO:0000790 - nuclear chromatin [Evidence IC] [PMID 8413209]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 10446242]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 7565763]; GO_function: GO:0001078 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [Evidence IMP] [PMID 10446242]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IMP] [PMID 14665463]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 10446242]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 10487921]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 8413209]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10446242]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10487921]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 16835445]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2546055]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2847035]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3062365]; GO_process: GO:0097201 - negative regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 21299653]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2252	Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 9398683]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 19805279]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9199167]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 9398683]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 10385523]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11739407]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_2256	Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 22180534]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11027267]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11027267]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2257	Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10436015]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10911987]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11011149]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10436015]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 10911987]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 16088870]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 10911987]; GO_function: GO:0031493 - nucleosomal histone binding [Evidence IDA] [PMID 10911987]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 12353039]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15610740]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006325 - chromatin organization [Evidence IMP,IPI] [PMID 10436015]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10911987]; GO_process: GO:0051382 - kinetochore assembly [Evidence IMP] [PMID 17452364]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 10911987]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 8598290]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2258	Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21944719]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21987634]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 22009199]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030061 - mitochondrial crista [Evidence IDA] [PMID 19528297]; GO_component: GO:0044284 - mitochondrial crista junction [Evidence IDA] [PMID 22009199]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 19528297]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 19528297]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21944719]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21987634]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 22009199]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP,IPI] [PMID 21944719]
AWJ20_2259	Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia; PAP2 has a paralog, TRF5, that arose from the whole genome duplication; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15828860]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15935758]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15935759]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16541108]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10066793]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0051575 - 5'-deoxyribose-5-phosphate lyase activity [Evidence IDA,IMP] [PMID 17983848]; GO_function: GO:0034459 - ATP-dependent 3'-5' RNA helicase activity [Evidence IDA] [PMID 22532666]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA] [PMID 12062100]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IMP,ISS] [PMID 15828860]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA] [PMID 15935758]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA,IMP] [PMID 15935759]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA,IMP] [PMID 16260630]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA,IGI] [PMID 16374505]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IGI,IMP] [PMID 16373491]; GO_process: GO:0006284 - base-excision repair [Evidence IGI,IMP] [PMID 17983848]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0071044 - histone mRNA catabolic process [Evidence IGI] [PMID 17179095]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IGI] [PMID 15145828]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA,IMP] [PMID 15828860]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA] [PMID 15935758]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IGI] [PMID 15935759]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IGI] [PMID 16373491]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IGI] [PMID 16374505]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IMP] [PMID 16431988]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IMP] [PMID 23762389]; GO_process: GO:0071031 - nuclear mRNA surveillance of mRNA 3'-end processing [Evidence IGI] [PMID 17410208]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IGI,IMP] [PMID 15935759]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 16973436]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 18007593]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 18591258]; GO_process: GO:0071040 - nuclear polyadenylation-dependent antisense transcript catabolic process [Evidence IMP] [PMID 18022365]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IGI] [PMID 16373491]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IGI,IMP] [PMID 15935758]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 16431988]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IGI] [PMID 16541108]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18007593]; GO_process: GO:0071037 - nuclear polyadenylation-dependent snRNA catabolic process [Evidence IMP] [PMID 15935758]; GO_process: GO:0071037 - nuclear polyadenylation-dependent snRNA catabolic process [Evidence IMP] [PMID 16431988]; GO_process: GO:0071036 - nuclear polyadenylation-dependent snoRNA catabolic process [Evidence IGI,IMP] [PMID 15935758]; GO_process: GO:0071036 - nuclear polyadenylation-dependent snoRNA catabolic process [Evidence IGI] [PMID 16373491]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IGI] [PMID 15145828]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IMP] [PMID 16431988]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IMP] [PMID 18456844]; GO_process: GO:0071047 - polyadenylation-dependent mRNA catabolic process [Evidence IMP] [PMID 19369424]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IGI] [PMID 16373491]; GO_process: GO:0071050 - snoRNA polyadenylation [Evidence IGI] [PMID 18951092]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 22319136]
AWJ20_2261	Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IMP] [PMID 11872141]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 8163546]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 22748138]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 23612966]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8163546]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 22748138]; GO_process: GO:0036258 - multivesicular body assembly [Evidence IGI] [PMID 22748138]; GO_process: GO:0036010 - protein localization to endosome [Evidence IGI] [PMID 23264632]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8163546]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 1493335]
AWJ20_2262	AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 20481588]; GO_function: GO:0071885 - N-terminal protein N-methyltransferase activity [Evidence IDA,IMP] [PMID 20481588]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0018016 - N-terminal peptidyl-proline dimethylation [Evidence IDA,IMP] [PMID 20481588]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI,IMP] [PMID 19055778]; GO_process: GO:0032259 - methylation [Evidence IEA]
AWJ20_2263	Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independent protein import into ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER; GO_component: GO:0005784 - Sec61 translocon complex [Evidence IDA] [PMID 8612571]; GO_component: GO:0005784 - Sec61 translocon complex [Evidence IDA] [PMID 9252322]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IMP] [PMID 1550957]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IDA] [PMID 9252322]; GO_function: GO:0015197 - peptide transporter activity [Evidence IMP] [PMID 10758167]; GO_function: GO:0005048 - signal sequence binding [Evidence IDA] [PMID 12134063]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 19696741]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 24314051]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 11076036]; GO_process: GO:0044743 - intracellular protein transmembrane import [Evidence IMP] [PMID 24314051]; GO_process: GO:0070843 - misfolded protein transport [Evidence IMP] [PMID 24314051]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 7758110]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IDA] [PMID 9252322]; GO_process: GO:0031204 - posttranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 9843581]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 10635318]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 9303298]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2264	Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 13680366]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 7754712]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 13680366]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 13680366]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 13680366]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 7739558]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2265	Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23451152]; GO_component: GO:0005829 - cytosol [Evidence IPI] [PMID 1474892]; GO_component: GO:0018444 - translation release factor complex [Evidence IDA] [PMID 7556078]; GO_function: GO:0003747 - translation release factor activity [Evidence IDA] [PMID 20947765]; GO_function: GO:0016149 - translation release factor activity, codon specific [Evidence IEA]; GO_function: GO:0016149 - translation release factor activity, codon specific [Evidence IMP,ISS] [PMID 9182990]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IGI,IMP] [PMID 18724935]; GO_process: GO:0006415 - translational termination [Evidence IDA] [PMID 20947765]; GO_process: GO:0006415 - translational termination [Evidence IMP,ISS] [PMID 9182990]
AWJ20_2266	Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11581258]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IMP] [PMID 18923140]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 11581258]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IMP,ISS] [PMID 9065405]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0071586 - CAAX-box protein processing [Evidence IMP] [PMID 9065405]; GO_process: GO:0007323 - peptide pheromone maturation [Evidence IDA] [PMID 11581258]; GO_process: GO:0007323 - peptide pheromone maturation [Evidence IMP] [PMID 9065405]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]
AWJ20_2267	High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 8893857]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000102 - L-methionine secondary active transmembrane transporter activity [Evidence IDA] [PMID 8893857]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0042883 - cysteine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0044690 - methionine import [Evidence IGI,IMP] [PMID 8893857]; GO_process: GO:0015821 - methionine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0000101 - sulfur amino acid transport [Evidence IMP] [PMID 8893857]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2269	Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16314178]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IMP] [PMID 11024051]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006342 - chromatin silencing [Evidence IGI,IMP] [PMID 11024051]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP,IPI] [PMID 11024051]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16314178]; GO_process: GO:0061188 - negative regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 16286008]; GO_process: GO:0061186 - negative regulation of chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 19372273]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17210643]; GO_process: GO:0061408 - positive regulation of transcription from RNA polymerase II promoter in response to heat stress [Evidence IMP] [PMID 20398213]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2270	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 9090056]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 9090056]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IC] [PMID 9090056]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_2272	5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IDA] [PMID 8855246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 2827162]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 8132553]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0033683 - nucleotide-excision repair, DNA incision [Evidence IDA] [PMID 8631896]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0045951 - positive regulation of mitotic recombination [Evidence IMP] [PMID 24189665]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 10713167]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 9799251]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0010525 - regulation of transposition, RNA-mediated [Evidence IMP] [PMID 10713167]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2273	Putative amidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004040 - amidase activity [Evidence IEA]; GO_function: GO:0004040 - amidase activity [Evidence ISS] [PMID 2263500]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
AWJ20_2274	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2280	Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11695919]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0046547 - trans-aconitate 3-methyltransferase activity [Evidence IEA]; GO_function: GO:0046547 - trans-aconitate 3-methyltransferase activity [Evidence IDA] [PMID 11695919]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA]
AWJ20_2281	Cytoplasmic NAD(+)-dependent protein deacetylase; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11226170]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17110954]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0070403 - NAD+ binding [Evidence IEA]; GO_function: GO:0017136 - NAD-dependent histone deacetylase activity [Evidence IDA] [PMID 10811920]; GO_function: GO:0017136 - NAD-dependent histone deacetylase activity [Evidence IMP] [PMID 10841563]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 11226170]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 16051752]; GO_process: GO:0001300 - chronological cell aging [Evidence IGI,IMP] [PMID 16051752]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 11226170]; GO_process: GO:0045950 - negative regulation of mitotic recombination [Evidence IGI,IMP] [PMID 16051752]; GO_process: GO:0006476 - protein deacetylation [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2282	Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Tae2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation involved in protein translation; monitors translation stress and signals this to Hsf1p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23222640]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23479637]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI,IMP] [PMID 20691087]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 23479637]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2283	Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; GO_component: GO:0030126 - COPI vesicle coat [Evidence IMP,ISS] [PMID 8617224]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8617224]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_2284	TFIID subunit (47 kDa); involved in promoter binding and RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 17660549]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2285	GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11447600]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 23613772]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11447600]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11447600]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 15514049]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 23613772]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 15514049]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000755 - cytogamy [Evidence IGI,IMP] [PMID 15514049]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI] [PMID 11447600]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI,IMP] [PMID 11713681]; GO_process: GO:0090038 - negative regulation of protein kinase C signaling [Evidence IGI,IMP] [PMID 11713681]; GO_process: GO:0032321 - positive regulation of Rho GTPase activity [Evidence IDA] [PMID 15514049]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IGI] [PMID 11447600]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI] [PMID 11447600]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 11713681]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2286	GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11447600]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 23613772]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11447600]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11447600]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 15514049]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 23613772]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 15514049]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000755 - cytogamy [Evidence IGI,IMP] [PMID 15514049]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI] [PMID 11447600]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI,IMP] [PMID 11713681]; GO_process: GO:0090038 - negative regulation of protein kinase C signaling [Evidence IGI,IMP] [PMID 11713681]; GO_process: GO:0032321 - positive regulation of Rho GTPase activity [Evidence IDA] [PMID 15514049]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IGI] [PMID 11447600]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI] [PMID 11447600]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 11713681]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2288	Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11382760]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 11382760]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 11689437]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_component: GO:0034045 - pre-autophagosomal structure membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 11382761]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 11382761]; GO_process: GO:0006914 - autophagy [Evidence IEA,IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 23382696]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0030242 - peroxisome degradation [Evidence IDA,IEP,IMP] [PMID 11382760]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2289	Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11382760]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 11382760]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 11689437]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_component: GO:0034045 - pre-autophagosomal structure membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 11382761]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 11382761]; GO_process: GO:0006914 - autophagy [Evidence IEA,IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 23382696]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0030242 - peroxisome degradation [Evidence IDA,IEP,IMP] [PMID 11382760]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2290	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 12499351]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15039776]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 15039776]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 9199164]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005771 - multivesicular body [Evidence IMP] [PMID 14523026]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15623581]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15707981]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 6759873]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 15707981]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 6759873]; GO_process: GO:0015846 - polyamine transport [Evidence IMP] [PMID 15707981]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2292	Mitochondrial hypothetical protein; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_2293	Vacuolar glutathione S-conjugate transporter; member of ATP-binding cassette family; ATPase activity required to support vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; has role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23658021]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8692889]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0015127 - bilirubin transmembrane transporter activity [Evidence IGI,IMP] [PMID 10790694]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 10220408]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12383937]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12755704]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 9217966]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015723 - bilirubin transport [Evidence IGI,IMP] [PMID 10790694]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046686 - response to cadmium ion [Evidence IEA]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 10220408]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 12755704]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 9217966]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 10790694]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 23658021]
AWJ20_2294	Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008252 - nucleotidase activity [Evidence IDA] [PMID 11934891]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006206 - pyrimidine nucleobase metabolic process [Evidence IMP] [PMID 11934891]
AWJ20_2295	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated; GO_component: GO:0005962 - mitochondrial isocitrate dehydrogenase complex (NAD+) [Evidence IDA] [PMID 16884682]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004449 - isocitrate dehydrogenase (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004449 - isocitrate dehydrogenase (NAD+) activity [Evidence IDA] [PMID 16884682]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006102 - isocitrate metabolic process [Evidence IDA] [PMID 16884682]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
AWJ20_2297	Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SEC1 has a paralog, HEH2, that arose from the whole genome duplication; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IDA] [PMID 18762579]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005639 - integral component of nuclear inner membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 16929305]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043007 - maintenance of rDNA [Evidence IMP] [PMID 18997772]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 11754482]
AWJ20_2298	AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003876 - AMP deaminase activity [Evidence IEA,IEA]; GO_function: GO:0003876 - AMP deaminase activity [Evidence IDA,IMP] [PMID 2690949]; GO_function: GO:0019239 - deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006188 - IMP biosynthetic process [Evidence IEA]; GO_process: GO:0032264 - IMP salvage [Evidence IEA]; GO_process: GO:0006178 - guanine salvage [Evidence IGI,IMP] [PMID 19635936]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IGI] [PMID 15869715]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IGI] [PMID 18433446]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IGI,IMP] [PMID 19635936]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IMP] [PMID 20087341]; GO_process: GO:0009168 - purine ribonucleoside monophosphate biosynthetic process [Evidence IEA]
AWJ20_2299	Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19194512]; GO_function: GO:0010181 - FMN binding [Evidence IEA,IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0003958 - NADPH-hemoprotein reductase activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016651 - oxidoreductase activity, acting on NAD(P)H [Evidence IEA]; GO_function: GO:0016651 - oxidoreductase activity, acting on NAD(P)H [Evidence IDA] [PMID 20802492]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 20802492]; GO_process: GO:0006809 - nitric oxide biosynthetic process [Evidence IMP] [PMID 23159617]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IDA] [PMID 20802492]
AWJ20_2300	N-terminus has a leader sequence with features reminiscent of mitochondrial import signals. Translated as a 28KDa precursor protein which is cleaved to a 21KDa mature form.
AWJ20_2301	Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 3029120]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 16162501]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 1924298]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IMP,ISS] [PMID 3029120]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0070156 - mitochondrial phenylalanyl-tRNA aminoacylation [Evidence IMP] [PMID 3029120]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 1924298]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2303	Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetically lethal with hac1 mutant suggesting a role in the maturation of secretory proteins; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 7478995]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 7478995]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 7478995]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 19433630]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2304	Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IDA] [PMID 7651383]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IMP] [PMID 8559655]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12909721]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12912927]; GO_component: GO:0031389 - Rad17 RFC-like complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 12604797]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 8995429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1346062]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IPI] [PMID 11389843]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IMP] [PMID 12665596]
AWJ20_2308	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2310	Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IDA] [PMID 12401799]; GO_function: GO:0004371 - glycerone kinase activity [Evidence ISS] [PMID 9038161]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0050354 - triokinase activity [Evidence IEA]; GO_process: GO:0019588 - anaerobic glycerol catabolic process [Evidence IEA]; GO_process: GO:0097237 - cellular response to toxic substance [Evidence IMP] [PMID 12401799]; GO_process: GO:0019563 - glycerol catabolic process [Evidence ISS] [PMID 9038161]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_2311	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004807 - triose-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004807 - triose-phosphate isomerase activity [Evidence IDA] [PMID 236471]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 11329176]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]
AWJ20_2315	Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11801737]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000164 - protein phosphatase type 1 complex [Evidence IDA] [PMID 10775415]; GO_function: GO:0071862 - protein phosphatase type 1 activator activity [Evidence IGI] [PMID 11801737]; GO_function: GO:0071862 - protein phosphatase type 1 activator activity [Evidence IGI] [PMID 18172024]; GO_function: GO:0004865 - protein serine/threonine phosphatase inhibitor activity [Evidence IGI,IMP] [PMID 17142459]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 11801737]; GO_process: GO:0051457 - maintenance of protein location in nucleus [Evidence IMP] [PMID 11801737]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]
AWJ20_2316	Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0000036 - ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process [Evidence ISS] [PMID 8394042]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0009107 - lipoate biosynthetic process [Evidence IMP] [PMID 9187370]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2321	Assembly chaperone for the 19S proteasome regulatory particle base; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19446323]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_component: GO:0005838 - proteasome regulatory particle [Evidence IDA] [PMID 11029046]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI] [PMID 19412159]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446322]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446323]; GO_process: GO:0006508 - proteolysis [Evidence IPI,ISS] [PMID 11029046]
AWJ20_2322	Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2323	Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10206705]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10206705]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042546 - cell wall biogenesis [Evidence IEA]; GO_process: GO:0032995 - regulation of fungal-type cell wall biogenesis [Evidence IGI,IMP] [PMID 10206705]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IGI] [PMID 11410349]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IMP] [PMID 12823808]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2324	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 15167894]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 16246728]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2325	hypothetical protein; mtc6 is synthetically sick with cdc13-1; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_2326	Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR); GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10835343]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9632789]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9259555]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IMP] [PMID 12882345]; GO_process: GO:0045861 - negative regulation of proteolysis [Evidence IMP,IPI] [PMID 10207067]; GO_process: GO:0006457 - protein folding [Evidence IDA,IPI,ISS] [PMID 10835343]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 12882345]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 9259555]
AWJ20_2327	Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004021 - L-alanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0004021 - L-alanine:2-oxoglutarate aminotransferase activity [Evidence IMP] [PMID 19396236]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042853 - L-alanine catabolic process [Evidence IEA]; GO_process: GO:0006523 - alanine biosynthetic process [Evidence IMP] [PMID 19396236]; GO_process: GO:0006524 - alanine catabolic process [Evidence IMP] [PMID 19396236]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 23527786]
AWJ20_2328	Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for destruction; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12052876]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IPI] [PMID 12052876]; GO_function: GO:0000774 - adenyl-nucleotide exchange factor activity [Evidence IDA,IPI] [PMID 12052876]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA,IMP] [PMID 23530227]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 12052876]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]
AWJ20_2330	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2331	Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 1293888]; GO_function: GO:0005274 - allantoin uptake transmembrane transporter activity [Evidence ISS] [PMID 1293888]; GO_function: GO:0005274 - allantoin uptake transmembrane transporter activity [Evidence IMP] [PMID 385448]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IMP] [PMID 385448]; GO_process: GO:0015720 - allantoin transport [Evidence IMP] [PMID 3549700]; GO_process: GO:0015720 - allantoin transport [Evidence IMP] [PMID 385448]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2332	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 20581295]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0001128 - RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IPI] [PMID 10906145]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 17603098]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 10906145]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7899074]; GO_process: GO:1901717 - positive regulation of gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:1901714 - positive regulation of urea catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_2334	Putative amidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004040 - amidase activity [Evidence IEA]; GO_function: GO:0004040 - amidase activity [Evidence ISS] [PMID 2263500]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
AWJ20_2335	Putative amidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004040 - amidase activity [Evidence IEA]; GO_function: GO:0004040 - amidase activity [Evidence ISS] [PMID 2263500]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
AWJ20_2337	Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17179087]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0016805 - dipeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070573 - metallodipeptidase activity [Evidence IDA,IMP] [PMID 19346245]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008242 - omega peptidase activity [Evidence IGI] [PMID 17179087]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0034701 - tripeptidase activity [Evidence IEA]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IMP] [PMID 17179087]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_2338	mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8119957]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence TAS] [PMID 9841679]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8119957]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 9841679]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISS] [PMID 3062383]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IDA,IPI] [PMID 15753296]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 2540596]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence ISS] [PMID 3062383]
AWJ20_2339	DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 8889513]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA,IPI,ISS] [PMID 8889513]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009063 - cellular amino acid catabolic process [Evidence IGI,IMP] [PMID 8889513]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IMP] [PMID 8889513]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_2342	Phosphatidylinositol-4-kinase; functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12015967]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19075114]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IMP] [PMID 8288577]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IDA] [PMID 9346907]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IGI] [PMID 10930462]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9346907]; GO_process: GO:0048015 - phosphatidylinositol-mediated signaling [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_2345	Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 11926067]; GO_component: GO:0009353 - mitochondrial oxoglutarate dehydrogenase complex [Evidence IDA] [PMID 2072900]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045252 - oxoglutarate dehydrogenase complex [Evidence IEA]; GO_function: GO:0004149 - dihydrolipoyllysine-residue succinyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004149 - dihydrolipoyllysine-residue succinyltransferase activity [Evidence ISA] [PMID 2115121]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0006103 - 2-oxoglutarate metabolic process [Evidence IMP] [PMID 2115121]; GO_process: GO:0033512 - L-lysine catabolic process to acetyl-CoA via saccharopine [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 10869431]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IC] [PMID 2072900]
AWJ20_2346	Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004103 - choline kinase activity [Evidence IEA]; GO_function: GO:0004103 - choline kinase activity [Evidence IGI,IMP] [PMID 10329685]; GO_function: GO:0004103 - choline kinase activity [Evidence IDA] [PMID 2536698]; GO_function: GO:0004305 - ethanolamine kinase activity [Evidence IGI,IMP] [PMID 10329685]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006657 - CDP-choline pathway [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IGI,IMP] [PMID 10329685]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IGI,IMP] [PMID 10329685]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_2347	Putative RNA-binding protein; required for the expression of early and middle sporulation genes; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IMP,ISS] [PMID 10806425]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEP] [PMID 10806425]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 11713679]; GO_process: GO:0006279 - premeiotic DNA replication [Evidence IMP] [PMID 11713679]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 11713679]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IGI,IMP] [PMID 10806425]
AWJ20_2348	Autophagy-related protein and dual specificity member of the E1 family; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10233150]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 10233148]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_function: GO:0019778 - Atg12 activating enzyme activity [Evidence IMP] [PMID 10233150]; GO_function: GO:0019779 - Atg8 activating enzyme [Evidence IMP] [PMID 11100732]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11038174]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11100732]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 12965207]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IDA,IMP] [PMID 15277523]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 10233150]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 12965207]; GO_process: GO:0006914 - autophagy [Evidence IEA,IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 23382696]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 10233150]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 12965207]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0032446 - protein modification by small protein conjugation [Evidence IMP] [PMID 10233150]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2349	Autophagy-related protein and dual specificity member of the E1 family; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10233150]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 10233148]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18497569]; GO_function: GO:0019778 - Atg12 activating enzyme activity [Evidence IMP] [PMID 10233150]; GO_function: GO:0019779 - Atg8 activating enzyme [Evidence IMP] [PMID 11100732]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11038174]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11100732]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 12965207]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IDA,IMP] [PMID 15277523]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 10233150]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 12965207]; GO_process: GO:0006914 - autophagy [Evidence IEA,IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 23382696]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 10233150]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 12965207]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0032446 - protein modification by small protein conjugation [Evidence IMP] [PMID 10233150]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2350	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0048500 - signal recognition particle [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IDA] [PMID 7925282]; GO_function: GO:0008312 - 7S RNA binding [Evidence IEA]; GO_function: GO:0008312 - 7S RNA binding [Evidence IDA] [PMID 14681587]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISA] [PMID 2187859]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence IPI] [PMID 7925282]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IEA]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IMP] [PMID 1655273]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence ISA] [PMID 2187859]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence IC] [PMID 7925282]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0045047 - protein targeting to ER [Evidence IPI] [PMID 7925282]
AWJ20_2351	Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0004795 - threonine synthase activity [Evidence IEA]; GO_function: GO:0004795 - threonine synthase activity [Evidence IMP] [PMID 8082795]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 8082795]
AWJ20_2352	Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 10523662]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IC] [PMID 9099738]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IMP,ISS] [PMID 15037765]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IMP] [PMID 18971324]; GO_process: GO:0006379 - mRNA cleavage [Evidence IMP] [PMID 18971324]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 18971324]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 18971324]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 18971324]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 18971324]
AWJ20_2354	Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17157937]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 17157937]
AWJ20_2355	Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 8649382]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI,IMP,IPI] [PMID 8649382]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 15367655]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IMP] [PMID 15367655]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IGI] [PMID 18755837]
AWJ20_2356	Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 8649382]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI,IMP,IPI] [PMID 8649382]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 15367655]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IMP] [PMID 15367655]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IGI] [PMID 18755837]
AWJ20_2358	Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8164662]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 8164662]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 9153234]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IDA] [PMID 8164662]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2360	3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 7754706]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA,IMP,ISM] [PMID 8125978]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 19470242]; GO_function: GO:0003988 - acetyl-CoA C-acyltransferase activity [Evidence IEA]; GO_function: GO:0003988 - acetyl-CoA C-acyltransferase activity [Evidence IDA] [PMID 7754706]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2365	Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15358789]; GO_process: GO:0006808 - regulation of nitrogen utilization [Evidence IMP] [PMID 11356843]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 8844145]
AWJ20_2366	Protein involved in RNA polymerase II transcription; is constitutively recruited to the CYC1 promoter and is required for recruitment of chromatin remodeling factors for the expression of CYC1 gene; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12524336]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12556496]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 18086892]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 21094070]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 21156811]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 12556496]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IPI] [PMID 12556496]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IPI] [PMID 18086892]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 19034519]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IPI] [PMID 21094070]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 21156811]; GO_process: GO:0034243 - regulation of transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 18086892]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 12524336]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI,IPI] [PMID 12556496]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_2367	Subunit of the INO80 chromatin remodeling complex; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0031011 - Ino80 complex [Evidence IDA] [PMID 12887900]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 12887900]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2372	Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1493793]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 2664469]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IMP] [PMID 3303332]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IGI,IMP] [PMID 7902583]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IGI,IMP] [PMID 9566882]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 2196175]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IGI,IMP] [PMID 3303332]; GO_process: GO:0043388 - positive regulation of DNA binding [Evidence IMP] [PMID 7902583]; GO_process: GO:0043388 - positive regulation of DNA binding [Evidence IDA] [PMID 8355698]; GO_process: GO:0045937 - positive regulation of phosphate metabolic process [Evidence IGI] [PMID 3915785]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 3303332]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 3915785]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 7902583]; GO_process: GO:2000679 - positive regulation of transcription regulatory region DNA binding [Evidence IMP] [PMID 9354395]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IDA,IMP] [PMID 1495962]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2373	hypothetical protein; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031901 - early endosome membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_2374	Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19466602]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23874617]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19466602]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 23874617]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 23874617]; GO_process: GO:0000470 - maturation of LSU-rRNA [Evidence IMP] [PMID 22893726]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IDA] [PMID 23945946]
AWJ20_2375	Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9741624]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 16835445]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9741624]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16107689]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]
AWJ20_2377	Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 17272295]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11489916]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17804645]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 15100437]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17272295]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 17804645]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 17272295]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2379	GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19380492]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 9171383]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA,IMP] [PMID 19380492]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0051457 - maintenance of protein location in nucleus [Evidence IPI] [PMID 19380492]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI] [PMID 9106207]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IMP] [PMID 9171383]; GO_process: GO:0090295 - nitrogen catabolite repression of transcription [Evidence IGI,IMP] [PMID 9171427]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2380	Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9696750]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 9733747]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence IDA,ISS] [PMID 9696750]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence IDA,ISS] [PMID 9733747]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 12032156]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 16436509]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IMP] [PMID 9696750]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IMP] [PMID 9733747]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2381	Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 12388763]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 19158382]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI,IMP] [PMID 19158382]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 12388763]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IDA] [PMID 19158382]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 10512884]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 12388763]
AWJ20_2382	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2383	top hit is XP_006261139.1 originated in Alligator mississippiensis
AWJ20_2386	Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11707418]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 11707418]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence TAS] [PMID 12362983]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11583615]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP,IPI] [PMID 11707418]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2387	Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11707418]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 11707418]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence TAS] [PMID 12362983]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11583615]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP,IPI] [PMID 11707418]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2389	Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12807768]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,ISS] [PMID 10559187]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 15574876]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]
AWJ20_2390	Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p; GO_component: GO:0000813 - ESCRT I complex [Evidence IPI] [PMID 11511343]; GO_component: GO:0000813 - ESCRT I complex [Evidence IDA] [PMID 15044434]; GO_component: GO:0000813 - ESCRT I complex [Evidence IPI] [PMID 16615894]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 11511343]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0032403 - protein complex binding [Evidence IDA,IPI] [PMID 17215868]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP,IPI] [PMID 11511343]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 11511343]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
AWJ20_2391	Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 11967269]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA,IEA]; GO_function: GO:0003995 - acyl-CoA dehydrogenase activity [Evidence IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence IEA,IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence ISA] [PMID 2189786]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence IEA]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence ISA] [PMID 2189786]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2393	Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IDA] [PMID 12003496]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IMP] [PMID 14970222]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0002943 - tRNA dihydrouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 12003496]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 14970222]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IGI] [PMID 12559567]
AWJ20_2394	Xylulokinase; converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004856 - xylulokinase activity [Evidence IEA]; GO_function: GO:0004856 - xylulokinase activity [Evidence IMP,ISS] [PMID 9595677]; GO_process: GO:0042732 - D-xylose metabolic process [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0005998 - xylulose catabolic process [Evidence IDA] [PMID 10981687]
AWJ20_2395	Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005787 - signal peptidase complex [Evidence IEA]; GO_component: GO:0005787 - signal peptidase complex [Evidence IDA] [PMID 1846444]; GO_component: GO:0005787 - signal peptidase complex [Evidence IDA] [PMID 8910564]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0045047 - protein targeting to ER [Evidence IGI,IPI] [PMID 8663399]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006465 - signal peptide processing [Evidence IEA]; GO_process: GO:0006465 - signal peptide processing [Evidence IGI,IMP,ISS] [PMID 8663399]
AWJ20_2396	Mitochondrial hypothetical protein involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase, ADCK1; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 23781023]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23781023]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0055088 - lipid homeostasis [Evidence IGI] [PMID 23781023]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IGI,IMP] [PMID 23781023]
AWJ20_2397	Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17448464]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17448464]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016274 - protein-arginine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0019702 - protein-arginine N5-methyltransferase activity [Evidence IDA] [PMID 11856739]; GO_function: GO:0019702 - protein-arginine N5-methyltransferase activity [Evidence IMP] [PMID 9873020]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0035246 - peptidyl-arginine N-methylation [Evidence IEA]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IDA] [PMID 11856739]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IMP] [PMID 9873020]
AWJ20_2398	Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15951236]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_function: GO:0008398 - sterol 14-demethylase activity [Evidence IEA]; GO_function: GO:0008398 - sterol 14-demethylase activity [Evidence IDA] [PMID 9087488]; GO_process: GO:0070988 - demethylation [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_2399	Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19720860]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence ISS] [PMID 9430719]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_process: GO:0010961 - cellular magnesium ion homeostasis [Evidence IMP] [PMID 19720860]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]
AWJ20_2401	Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11003641]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA,IMP] [PMID 10445027]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 11904169]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA,IMP] [PMID 10445027]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 11904169]; GO_process: GO:0070940 - dephosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 16301539]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 10445027]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 12370301]
AWJ20_2403	Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 9434768]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 12235155]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA,IMP] [PMID 9430634]; GO_process: GO:0040008 - regulation of growth [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2408	Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IGI,IMP,ISS] [PMID 11157982]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IGI,ISS] [PMID 11157982]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0019153 - protein-disulfide reductase (glutathione) activity [Evidence IDA] [PMID 16002399]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006662 - glycerol ether metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IGI] [PMID 11157982]
AWJ20_2409	Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 20038530]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 20038530]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000469 - cleavage involved in rRNA processing [Evidence IMP] [PMID 20038530]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 20038530]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2410	Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IDA] [PMID 19864628]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
AWJ20_2411	Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IDA] [PMID 12743123]
AWJ20_2412	Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes; GO_component: GO:0000417 - HIR complex [Evidence IDA,IPI] [PMID 16264190]; GO_component: GO:0000417 - HIR complex [Evidence IDA] [PMID 16303565]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12524332]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16264190]; GO_function: GO:0031491 - nucleosome binding [Evidence IMP] [PMID 16264190]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16264190]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16303565]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 1406694]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 16449659]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2413	Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10799523]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10799523]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 19380492]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence ISA] [PMID 7568152]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 9106207]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IMP] [PMID 19380492]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IGI] [PMID 7568152]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0090294 - nitrogen catabolite activation of transcription [Evidence IGI,IMP] [PMID 7568152]; GO_process: GO:0090294 - nitrogen catabolite activation of transcription [Evidence IGI,IMP] [PMID 8622686]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 7568152]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2416	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 15215105]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IMP] [PMID 23106982]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IMP] [PMID 15215105]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IMP] [PMID 15649438]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0060003 - copper ion export [Evidence IMP] [PMID 23106982]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IMP] [PMID 15215105]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IMP] [PMID 15649438]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0010107 - potassium ion import [Evidence IGI,IMP] [PMID 17189489]; GO_process: GO:0006813 - potassium ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2420	N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8183942]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA,IMP] [PMID 8183942]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2422	Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008559 - xenobiotic-transporting ATPase activity [Evidence TAS] [PMID 10581358]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042493 - response to drug [Evidence TAS] [PMID 11421285]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2423	Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9687494]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005342 - organic acid transmembrane transporter activity [Evidence IDA] [PMID 10419965]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0015849 - organic acid transport [Evidence IDA] [PMID 10419965]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2428	Ubiquitin hydrolase that deubiquitinates ILV cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 17145966]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 10069815]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 19410548]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 8247125]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9119204]; GO_process: GO:0010995 - free ubiquitin chain depolymerization [Evidence IDA] [PMID 19410548]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IGI] [PMID 23444383]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006275 - regulation of DNA replication [Evidence IMP] [PMID 8657109]; GO_process: GO:0010992 - ubiquitin homeostasis [Evidence IMP] [PMID 19410548]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17145966]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 17376168]
AWJ20_2429	Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0017059 - serine C-palmitoyltransferase complex [Evidence IMP] [PMID 1556076]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IEA]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IMP] [PMID 1556076]; GO_function: GO:0004758 - serine C-palmitoyltransferase activity [Evidence IGI] [PMID 8058731]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 1556076]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]
AWJ20_2430	tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 3312232]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 20844078]; GO_function: GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [Evidence IDA] [PMID 6297798]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0051730 - GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [Evidence IDA] [PMID 8428918]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IDA] [PMID 3277966]; GO_function: GO:0003972 - RNA ligase (ATP) activity [Evidence IDA] [PMID 3512545]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 8898194]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0032056 - positive regulation of translation in response to stress [Evidence IMP,IPI] [PMID 20844078]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IMP] [PMID 1537841]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IDA] [PMID 2207062]
AWJ20_2431	Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0016743 - carboxyl- or carbamoyltransferase activity [Evidence IEA]; GO_function: GO:0004585 - ornithine carbamoyltransferase activity [Evidence IEA]; GO_function: GO:0004585 - ornithine carbamoyltransferase activity [Evidence IDA] [PMID 7029528]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IMP] [PMID 2897249]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006591 - ornithine metabolic process [Evidence IEA]
AWJ20_2434	High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IMP,ISS] [PMID 8637895]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000006 - high affinity zinc uptake transmembrane transporter activity [Evidence IMP,ISS] [PMID 8637895]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006830 - high-affinity zinc ion transport [Evidence IMP] [PMID 8637895]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0071577 - zinc ion transmembrane transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]
AWJ20_2443	Putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0042788 - polysomal ribosome [Evidence IDA] [PMID 21076151]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence ISS] [PMID 9133744]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI] [PMID 21076151]; GO_process: GO:0051607 - defense response to virus [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IGI,IMP] [PMID 10922069]; GO_process: GO:0006417 - regulation of translation [Evidence IGI,IMP] [PMID 11438647]
AWJ20_2444	EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 18298591]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IGI] [PMID 18298591]; GO_process: GO:0006914 - autophagy [Evidence IGI] [PMID 18298591]; GO_process: GO:0009267 - cellular response to starvation [Evidence IGI] [PMID 18298591]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 10082585]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 15265867]; GO_process: GO:0048017 - inositol lipid-mediated signaling [Evidence IGI] [PMID 15265867]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
AWJ20_2448	S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004014 - adenosylmethionine decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004014 - adenosylmethionine decarboxylase activity [Evidence IDA] [PMID 2266128]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0006557 - S-adenosylmethioninamine biosynthetic process [Evidence IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006596 - polyamine biosynthetic process [Evidence IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IMP] [PMID 7929015]; GO_process: GO:0006597 - spermine biosynthetic process [Evidence IEA]; GO_process: GO:0006597 - spermine biosynthetic process [Evidence IMP] [PMID 7929015]
AWJ20_2449	RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins; component of ribosome-bound RQC (ribosome quality control) complex required for degradation of polypeptides arising from stalled translation; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23479637]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17283062]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 20835226]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 20835226]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 17283062]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IGI] [PMID 17283062]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 17283062]; GO_process: GO:0010498 - proteasomal protein catabolic process [Evidence IGI,IMP] [PMID 24261871]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 17283062]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 20835226]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23479637]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20835226]
AWJ20_2450	Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9445368]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2451	L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0004414 - homoserine O-acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004414 - homoserine O-acetyltransferase activity [Evidence IDA,IMP] [PMID 3301801]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009092 - homoserine metabolic process [Evidence IDA,IMP] [PMID 3301801]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 6035500]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IMP] [PMID 1101032]
AWJ20_2452	Mitochondrial protein; forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9774408]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070899 - mitochondrial tRNA wobble uridine modification [Evidence IMP] [PMID 15509579]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IEA]
AWJ20_2453	ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005471 - ATP:ADP antiporter activity [Evidence IMP] [PMID 18485069]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 15238515]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0015866 - ADP transport [Evidence IMP] [PMID 18485069]; GO_process: GO:0015867 - ATP transport [Evidence IMP] [PMID 18485069]; GO_process: GO:0006839 - mitochondrial transport [Evidence IMP] [PMID 18485069]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2454	Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 21306442]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0070290 - N-acylphosphatidylethanolamine-specific phospholipase D activity [Evidence IEA]; GO_function: GO:0070290 - N-acylphosphatidylethanolamine-specific phospholipase D activity [Evidence ISS] [PMID 15878693]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0070291 - N-acylethanolamine metabolic process [Evidence IMP] [PMID 15878693]; GO_process: GO:0070292 - N-acylphosphatidylethanolamine metabolic process [Evidence IMP] [PMID 15878693]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]
AWJ20_2455	Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003864 - 3-methyl-2-oxobutanoate hydroxymethyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003864 - 3-methyl-2-oxobutanoate hydroxymethyltransferase activity [Evidence IMP,ISS] [PMID 11154694]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]
AWJ20_2456	Putative acyltransferase with similarity to Eeb1p and Eht1p; has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence ISS] [PMID 16361250]; GO_process: GO:0051792 - medium-chain fatty acid biosynthetic process [Evidence IGI] [PMID 16361250]
AWJ20_2457	Accessory subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev3p, Pol31p and Pol32p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16452144]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16546083]; GO_component: GO:0016035 - zeta DNA polymerase complex [Evidence IDA] [PMID 8658138]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 8658138]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 12514101]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 11313481]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 3897795]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 9765213]
AWJ20_2458	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_2459	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase; GO_component: GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex [Evidence IEA]; GO_component: GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex [Evidence IDA] [PMID 19417106]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19417106]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA,IEA]; GO_function: GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 19417106]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IGI] [PMID 18667535]; GO_process: GO:0070681 - glutaminyl-tRNAGln biosynthesis via transamidation [Evidence IEA]; GO_process: GO:0070681 - glutaminyl-tRNAGln biosynthesis via transamidation [Evidence IDA] [PMID 19417106]; GO_process: GO:0032543 - mitochondrial translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
AWJ20_2460	Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; relocalizes to the cytosol in response to hypoxia; potentially phosphorylated by Cdc28p; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0042406 - extrinsic component of endoplasmic reticulum membrane [Evidence IDA] [PMID 19416104]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19416104]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 18493054]; GO_function: GO:0003682 - chromatin binding [Evidence IDA,IMP] [PMID 19581291]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 16079223]; GO_function: GO:0042393 - histone binding [Evidence IDA,IMP] [PMID 19581291]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IMP] [PMID 15824130]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IMP] [PMID 16079223]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IMP] [PMID 19581291]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 18493054]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 19683497]
AWJ20_2461	Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; relocalizes to the cytosol in response to hypoxia; potentially phosphorylated by Cdc28p; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0042406 - extrinsic component of endoplasmic reticulum membrane [Evidence IDA] [PMID 19416104]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19416104]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 18493054]; GO_function: GO:0003682 - chromatin binding [Evidence IDA,IMP] [PMID 19581291]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 16079223]; GO_function: GO:0042393 - histone binding [Evidence IDA,IMP] [PMID 19581291]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IMP] [PMID 15824130]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IMP] [PMID 16079223]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IMP] [PMID 19581291]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 18493054]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 19683497]
AWJ20_2462	Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9679135]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005785 - signal recognition particle receptor complex [Evidence IPI] [PMID 9679135]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IPI] [PMID 7844142]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005047 - signal recognition particle binding [Evidence IMP,ISS] [PMID 1327299]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IEA]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IC,TAS] [PMID 7844142]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1327299]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2463	Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 11935221]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0032934 - sterol binding [Evidence IDA] [PMID 23027975]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0015918 - sterol transport [Evidence IGI,IMP] [PMID 23027975]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2464	Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates unfolded protein response (UPR) by promoting the decay of HAC1 RNA; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 10747087]; GO_component: GO:0005795 - Golgi stack [Evidence IDA] [PMID 12802060]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IDA] [PMID 23129774]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10747087]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 20375281]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 20059749]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 3311726]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 9447979]; GO_function: GO:0000149 - SNARE binding [Evidence IDA,IPI] [PMID 18388317]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 15689495]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20375281]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 15689495]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 2504726]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 7593181]; GO_process: GO:0048194 - Golgi vesicle budding [Evidence IGI] [PMID 18388317]; GO_process: GO:0048211 - Golgi vesicle docking [Evidence IMP] [PMID 9545229]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IMP] [PMID 9157884]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 20059749]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 20059749]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20375281]; GO_process: GO:1990261 - pre-mRNA catabolic process [Evidence IMP] [PMID 22844259]; GO_process: GO:0006461 - protein complex assembly [Evidence IDA] [PMID 8603910]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 22844259]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IGI,IMP] [PMID 18388317]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_2465	Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 16839886]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IBA]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IDA,IPI] [PMID 11394869]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IMP] [PMID 2105453]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8756677]; GO_function: GO:0031683 - G-protein beta/gamma-subunit complex binding [Evidence IBA,IEA]; GO_function: GO:0001664 - G-protein coupled receptor binding [Evidence IBA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11394869]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 1900495]; GO_function: GO:0019001 - guanyl nucleotide binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IBA,IEA,IEA]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 12556475]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 2105453]; GO_process: GO:0007189 - adenylate cyclase-activating G-protein coupled receptor signaling pathway [Evidence IBA,IEA]; GO_process: GO:0031684 - heterotrimeric G-protein complex cycle [Evidence IMP] [PMID 2107073]; GO_process: GO:0048017 - inositol lipid-mediated signaling [Evidence IMP] [PMID 16839886]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 3113739]; GO_process: GO:0071701 - regulation of MAPK export from nucleus [Evidence IMP] [PMID 12556475]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA,IEA]
AWJ20_2468	Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 7651518]; GO_function: GO:0005267 - potassium channel activity [Evidence IEA]; GO_function: GO:0005267 - potassium channel activity [Evidence IDA,IMP,ISS] [PMID 7651518]; GO_function: GO:0005244 - voltage-gated ion channel activity [Evidence IEA]; GO_function: GO:0005249 - voltage-gated potassium channel activity [Evidence IMP] [PMID 16133265]; GO_process: GO:0030007 - cellular potassium ion homeostasis [Evidence IDA,IMP] [PMID 7651518]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0071805 - potassium ion transmembrane transport [Evidence IEA]; GO_process: GO:0034765 - regulation of ion transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2469	Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23509072]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IDA] [PMID 1939170]; GO_component: GO:0005749 - mitochondrial respiratory chain complex II [Evidence IDA] [PMID 9822678]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0051538 - 3 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IEA]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IDA] [PMID 13445213]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IGI,IMP] [PMID 16232921]; GO_process: GO:0045333 - cellular respiration [Evidence IGI,IMP] [PMID 16232921]; GO_process: GO:0006121 - mitochondrial electron transport, succinate to ubiquinone [Evidence TAS] [PMID 9929002]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IMP] [PMID 10224250]
AWJ20_2470	Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 1429680]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 1429680]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0010992 - ubiquitin homeostasis [Evidence IC] [PMID 1429680]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_2471	Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 21149575]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 19061648]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2475	Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004766 - spermidine synthase activity [Evidence IEA]; GO_function: GO:0004766 - spermidine synthase activity [Evidence IMP,ISS] [PMID 9073064]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006596 - polyamine biosynthetic process [Evidence IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IMP] [PMID 9073064]
AWJ20_2477	Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15078877]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15178413]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15078877]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15178413]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2478	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 7589446]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016624 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Evidence IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IEA,IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IMP] [PMID 11589696]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]
AWJ20_2479	GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 22575457]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 22575457]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23127800]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11914276]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 20162532]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23127800]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 6438624]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8106517]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0007190 - activation of adenylate cyclase activity [Evidence IDA] [PMID 8106517]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 2558958]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 2981630]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 3891097]; GO_process: GO:0000411 - positive regulation of transcription by galactose [Evidence IMP] [PMID 16292676]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 12782684]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 1547504]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 15917658]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 12839995]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 8034612]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_2480	Subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC2 has a paralog, VTC3, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17079729]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11823419]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0033254 - vacuolar transporter chaperone complex [Evidence IPI] [PMID 11823419]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016237 - microautophagy [Evidence IDA,IMP] [PMID 17079729]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IGI,IMP] [PMID 11102525]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 10480897]; GO_process: GO:0007034 - vacuolar transport [Evidence IDA,IMP] [PMID 17079729]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP,IPI] [PMID 11823419]
AWJ20_2482	Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0008441 - 3'(2'),5'-bisphosphate nucleotidase activity [Evidence IEA,IEA]; GO_function: GO:0008441 - 3'(2'),5'-bisphosphate nucleotidase activity [Evidence IDA] [PMID 7809627]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0042538 - hyperosmotic salinity response [Evidence IMP] [PMID 8393782]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 8393782]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 8910555]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence IEA]
AWJ20_2483	Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8631921]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IDA] [PMID 9020857]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9182588]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
AWJ20_2484	Alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IMP] [PMID 8877369]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0042281 - dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [Evidence IMP] [PMID 10336995]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IMP] [PMID 8877369]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 15794922]; GO_process: GO:0006490 - oligosaccharide-lipid intermediate biosynthetic process [Evidence IMP] [PMID 10336995]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 8877369]
AWJ20_2487	Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 11950926]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0032977 - membrane insertase activity [Evidence IMP,ISS] [PMID 11950926]; GO_function: GO:0032977 - membrane insertase activity [Evidence IPI] [PMID 17452441]; GO_function: GO:0032977 - membrane insertase activity [Evidence IGI] [PMID 17922846]; GO_process: GO:0051205 - protein insertion into membrane [Evidence IEA]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IGI,IMP] [PMID 11950926]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IPI] [PMID 17452441]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IGI] [PMID 17922846]
AWJ20_2489	Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9442111]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9732290]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 9442111]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 9732290]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9732290]; GO_component: GO:0016460 - myosin II complex [Evidence IPI] [PMID 15210731]; GO_component: GO:0016459 - myosin complex [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0000146 - microfilament motor activity [Evidence ISS] [PMID 9519900]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000915 - actomyosin contractile ring assembly [Evidence IMP] [PMID 9732290]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IMP] [PMID 16148042]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IEP] [PMID 9442111]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IEP] [PMID 9732290]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 12589071]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 3322809]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 9732290]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2491	Homoserine kinase; conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004413 - homoserine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004413 - homoserine kinase activity [Evidence IDA] [PMID 2165904]; GO_function: GO:0004413 - homoserine kinase activity [Evidence ISS] [PMID 8973190]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009092 - homoserine metabolic process [Evidence IDA] [PMID 2165904]; GO_process: GO:0006549 - isoleucine metabolic process [Evidence TAS] [PMID 8973190]; GO_process: GO:0006555 - methionine metabolic process [Evidence TAS] [PMID 8973190]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 17247984]; GO_process: GO:0006566 - threonine metabolic process [Evidence IEA]
AWJ20_2492	Larger subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0017087 - mitochondrial processing peptidase complex [Evidence IDA] [PMID 2905264]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IDA] [PMID 2905264]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006627 - protein processing involved in protein targeting to mitochondrion [Evidence IMP] [PMID 3061808]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_2494	hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_2495	Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2496	TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA] [PMID 11677244]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10817999]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10818000]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 8980232]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0032947 - protein complex scaffold [Evidence IDA,IMP] [PMID 15143185]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9844639]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 10713163]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12600943]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9288741]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9288742]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2497	Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 2826479]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17308036]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17308036]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IGI,IMP,IPI] [PMID 17308036]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 7739558]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2498	Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_2499	Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0003855 - 3-dehydroquinate dehydratase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003856 - 3-dehydroquinate synthase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004765 - shikimate kinase activity [Evidence IDA] [PMID 6355828]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_2501	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720285]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISS] [PMID 9233818]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IMP,ISS] [PMID 9233818]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IDA] [PMID 9848662]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IGI] [PMID 15911574]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 9233818]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IMP] [PMID 16540695]; GO_process: GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [Evidence IMP] [PMID 16540695]
AWJ20_2502	Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 21822217]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10849420]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000280 - nuclear division [Evidence IMP] [PMID 15515129]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 10849420]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2503	Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19416104]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 19416104]; GO_function: GO:0004161 - dimethylallyltranstransferase activity [Evidence IEA]; GO_function: GO:0004161 - dimethylallyltranstransferase activity [Evidence IDA] [PMID 2681213]; GO_function: GO:0004337 - geranyltranstransferase activity [Evidence IEA]; GO_function: GO:0004337 - geranyltranstransferase activity [Evidence IDA] [PMID 2681213]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 1779710]; GO_process: GO:0045337 - farnesyl diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0045337 - farnesyl diphosphate biosynthetic process [Evidence IDA] [PMID 2681213]; GO_process: GO:0033384 - geranyl diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IDA] [PMID 2681213]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
AWJ20_2504	Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19416104]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 19416104]; GO_function: GO:0004161 - dimethylallyltranstransferase activity [Evidence IEA]; GO_function: GO:0004161 - dimethylallyltranstransferase activity [Evidence IDA] [PMID 2681213]; GO_function: GO:0004337 - geranyltranstransferase activity [Evidence IEA]; GO_function: GO:0004337 - geranyltranstransferase activity [Evidence IDA] [PMID 2681213]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 1779710]; GO_process: GO:0045337 - farnesyl diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0045337 - farnesyl diphosphate biosynthetic process [Evidence IDA] [PMID 2681213]; GO_process: GO:0033384 - geranyl diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IDA] [PMID 2681213]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
AWJ20_2505	Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15528184]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12102729]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 12102729]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 11583615]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 12374754]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 15528184]
AWJ20_2506	Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15528184]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12102729]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 12102729]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12837249]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 11583615]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IPI] [PMID 12374754]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 15528184]
AWJ20_2507	RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence ISS] [PMID 9396823]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IMP] [PMID 10716935]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IGI] [PMID 10716935]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 10716935]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IMP] [PMID 10716935]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_2509	3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12206772]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12206772]; GO_function: GO:0046568 - 3-methylbutanol:NAD(P) oxidoreductase activity [Evidence IEA]; GO_function: GO:0046568 - 3-methylbutanol:NAD(P) oxidoreductase activity [Evidence IMP] [PMID 16999827]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0043892 - methylglyoxal reductase (NADPH-dependent) activity [Evidence IEA]; GO_function: GO:0043892 - methylglyoxal reductase (NADPH-dependent) activity [Evidence IDA] [PMID 12722185]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0008204 - ergosterol metabolic process [Evidence IGI,IMP] [PMID 16598690]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 16999827]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2510	Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 18397879]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 14515169]; GO_component: GO:0005634 - nucleus [Evidence IGI] [PMID 18397879]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP] [PMID 14515169]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 18397879]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI,IMP] [PMID 18397879]; GO_process: GO:0008105 - asymmetric protein localization [Evidence IMP] [PMID 18397879]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 18397879]
AWJ20_2512	hypothetical protein; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9121474]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9395535]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0046907 - intracellular transport [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 9636166]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 17904525]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 12082158]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2513	Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 2138512]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000922 - spindle pole [Evidence IDA] [PMID 14562095]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 11729143]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 2138512]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 8106549]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 22734002]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0008569 - minus-end-directed microtubule motor activity [Evidence IDA] [PMID 8041770]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 16107877]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IMP] [PMID 2138512]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IDA,IMP] [PMID 11729143]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IGI] [PMID 9201713]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 16380440]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 19386762]; GO_process: GO:0000743 - nuclear migration involved in conjugation with cellular fusion [Evidence IMP] [PMID 2138512]
AWJ20_2516	Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9852145]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852145]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 17704259]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 12242280]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IMP] [PMID 9852145]
AWJ20_2517	ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 11007476]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19061897]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070417 - cellular response to cold [Evidence IMP] [PMID 11855848]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 11063674]; GO_process: GO:0048255 - mRNA stabilization [Evidence IMP] [PMID 15220333]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11557770]; GO_process: GO:0061399 - positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion [Evidence IMP] [PMID 11509659]; GO_process: GO:0061419 - positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [Evidence IMP] [PMID 11509659]; GO_process: GO:0036083 - positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 9927444]
AWJ20_2518	ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 11007476]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19061897]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070417 - cellular response to cold [Evidence IMP] [PMID 11855848]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 11063674]; GO_process: GO:0048255 - mRNA stabilization [Evidence IMP] [PMID 15220333]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11557770]; GO_process: GO:0061399 - positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion [Evidence IMP] [PMID 11509659]; GO_process: GO:0061419 - positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [Evidence IMP] [PMID 11509659]; GO_process: GO:0036083 - positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 9927444]
AWJ20_2520	Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16452144]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16546083]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005657 - replication fork [Evidence IPI] [PMID 17517887]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 8751446]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0017125 - deoxycytidyl transferase activity [Evidence IDA] [PMID 8751446]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IMP] [PMID 10540291]; GO_process: GO:0070987 - error-free translesion synthesis [Evidence IDA] [PMID 8751446]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 17248528]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IDA] [PMID 8751446]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IGI] [PMID 9765213]
AWJ20_2521	Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14718557]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0030955 - potassium ion binding [Evidence IEA]; GO_function: GO:0004743 - pyruvate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004743 - pyruvate kinase activity [Evidence IDA] [PMID 12063246]; GO_function: GO:0004743 - pyruvate kinase activity [Evidence IMP] [PMID 323230]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 323230]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IMP] [PMID 323230]
AWJ20_2523	Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11158296]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015228 - coenzyme A transmembrane transporter activity [Evidence IMP] [PMID 11158296]; GO_process: GO:0015880 - coenzyme A transport [Evidence IMP] [PMID 11158296]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2524	tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0061503 - tRNA threonylcarbamoyladenosine dehydratase [Evidence IMP] [PMID 23242255]; GO_process: GO:0061504 - cyclic threonylcarbamoyladenosine biosynthetic process [Evidence IMP] [PMID 23242255]
AWJ20_2526	Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; induces the appearance of the [PIN+] prion when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 23577202]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23577202]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034316 - negative regulation of Arp2/3 complex-mediated actin nucleation [Evidence IDA,IPI] [PMID 23577202]
AWJ20_2527	Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11687631]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11742990]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11752412]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11742990]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11805083]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11742990]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11752412]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11805083]; GO_process: GO:0034729 - histone H3-K79 methylation [Evidence IMP] [PMID 18083099]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15146080]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0031126 - snoRNA 3'-end processing [Evidence IMP] [PMID 15146080]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 15146080]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IPI] [PMID 12819204]; GO_process: GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled [Evidence IPI] [PMID 12819204]
AWJ20_2528	Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008478 - pyridoxal kinase activity [Evidence IEA,IEA]; GO_function: GO:0008478 - pyridoxal kinase activity [Evidence ISA] [PMID 9099727]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009443 - pyridoxal 5'-phosphate salvage [Evidence IEA]; GO_process: GO:0042823 - pyridoxal phosphate biosynthetic process [Evidence IC] [PMID 9099727]
AWJ20_2529	Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 1869583]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8144572]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 1869583]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 1400408]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 15342786]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9774392]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 10567418]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 15342786]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9674429]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1473150]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IMP] [PMID 1729605]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2531	Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 8314797]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20681974]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI,IMP] [PMID 20681974]; GO_process: GO:0016197 - endosomal transport [Evidence IMP] [PMID 20526336]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 18178563]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 18178563]; GO_process: GO:0007034 - vacuolar transport [Evidence IGI] [PMID 20526336]
AWJ20_2532	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2533	Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but is not likely to function as a transmembrane transporter; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 19237599]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IGI,IMP] [PMID 11257114]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IMP,IPI] [PMID 12808034]
AWJ20_2534	Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 7723016]; GO_process: GO:0016071 - mRNA metabolic process [Evidence IMP] [PMID 7723016]
AWJ20_2535	hypothetical protein; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 19064668]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 8655575]; GO_component: GO:0070250 - mating projection membrane [Evidence IDA] [PMID 19064668]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070941 - eisosome assembly [Evidence IMP] [PMID 19564405]; GO_process: GO:0090002 - establishment of protein localization to plasma membrane [Evidence IMP] [PMID 20581291]; GO_process: GO:0001933 - negative regulation of protein phosphorylation [Evidence IMP] [PMID 19564405]; GO_process: GO:0007009 - plasma membrane organization [Evidence IMP] [PMID 19564405]; GO_process: GO:0009306 - protein secretion [Evidence IGI,IMP] [PMID 8655575]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2539	Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IDA] [PMID 9250663]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9335339]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 17895371]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_2540	RNA polymerase I largest subunit A190; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15520468]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 3054507]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IGI] [PMID 2023944]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IMP] [PMID 3054507]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2545	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10903515]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015244 - fluconazole transporter activity [Evidence ISS] [PMID 9235926]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI,IMP] [PMID 10572257]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI] [PMID 9235926]; GO_process: GO:0015893 - drug transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9235926]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2546	Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 22404710]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 22404710]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:2001172 - positive regulation of glucose catabolic process to ethanol [Evidence IMP] [PMID 8264540]; GO_process: GO:0090180 - positive regulation of thiamine biosynthetic process [Evidence IGI,IMP] [PMID 16850348]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19013460]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8264540]
AWJ20_2548	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_2549	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004399 - histidinol dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004399 - histidinol dehydrogenase activity [Evidence IDA] [PMID 379004]; GO_function: GO:0004399 - histidinol dehydrogenase activity [Evidence IMP] [PMID 5919326]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004635 - phosphoribosyl-AMP cyclohydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004635 - phosphoribosyl-AMP cyclohydrolase activity [Evidence IDA] [PMID 379004]; GO_function: GO:0004635 - phosphoribosyl-AMP cyclohydrolase activity [Evidence IMP] [PMID 5919326]; GO_function: GO:0004636 - phosphoribosyl-ATP diphosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004636 - phosphoribosyl-ATP diphosphatase activity [Evidence IDA] [PMID 379004]; GO_function: GO:0004636 - phosphoribosyl-ATP diphosphatase activity [Evidence IMP] [PMID 5919326]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 5919326]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2552	Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004462 - lactoylglutathione lyase activity [Evidence IEA,IEA]; GO_function: GO:0004462 - lactoylglutathione lyase activity [Evidence IGI] [PMID 8824231]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IGI] [PMID 8824231]; GO_process: GO:0019243 - methylglyoxal catabolic process to D-lactate [Evidence IDA] [PMID 8824231]
AWJ20_2553	Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 24855027]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12062425]; GO_function: GO:0004198 - calcium-dependent cysteine-type endopeptidase activity [Evidence IDA,IMP] [PMID 22761449]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IDA] [PMID 11983181]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16170310]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16301538]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 20624963]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_2554	Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21925384]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0016281 - eukaryotic translation initiation factor 4F complex [Evidence IGI,IMP,ISS] [PMID 8336723]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12810920]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence TAS] [PMID 9841679]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0034063 - stress granule assembly [Evidence IMP] [PMID 18981231]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 12810920]
AWJ20_2555	ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10419517]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 9287326]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0019904 - protein domain specific binding [Evidence IDA] [PMID 7870180]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 20855529]; GO_process: GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 17167105]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IGI] [PMID 11410533]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IGI] [PMID 16269334]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0051091 - positive regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 16269334]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 11389845]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 10688918]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]
AWJ20_2558	Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9168472]; GO_component: GO:0010009 - cytoplasmic side of endosome membrane [Evidence IDA] [PMID 9168472]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 9702203]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 9168472]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI] [PMID 9335586]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IGI,IPI] [PMID 10021387]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 1493335]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IMP] [PMID 9168472]; GO_process: GO:0006906 - vesicle fusion [Evidence IMP] [PMID 9168472]
AWJ20_2559	Ferrochelatase; a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7629135]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004325 - ferrochelatase activity [Evidence IEA,IEA]; GO_function: GO:0004325 - ferrochelatase activity [Evidence IDA] [PMID 1304908]; GO_function: GO:0004325 - ferrochelatase activity [Evidence IMP] [PMID 2185242]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA]
AWJ20_2560	Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17890783]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IEA]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IGI,IMP] [PMID 17675291]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IMP] [PMID 17726007]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IEA]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IMP] [PMID 17726007]; GO_function: GO:0047184 - 1-acylglycerophosphocholine O-acyltransferase activity [Evidence IMP] [PMID 17951629]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IDA,IMP] [PMID 17890783]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0046474 - glycerophospholipid biosynthetic process [Evidence IGI,IMP] [PMID 17675291]; GO_process: GO:0046474 - glycerophospholipid biosynthetic process [Evidence IMP] [PMID 17726007]; GO_process: GO:0046474 - glycerophospholipid biosynthetic process [Evidence IMP] [PMID 17890783]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
AWJ20_2561	Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 16647879]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031901 - early endosome membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 15632165]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 12370247]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IDA] [PMID 12370247]; GO_function: GO:0019706 - protein-cysteine S-palmitoyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0018345 - protein palmitoylation [Evidence IDA] [PMID 12370247]; GO_process: GO:0018345 - protein palmitoylation [Evidence IDA,IMP] [PMID 16227572]; GO_process: GO:0018345 - protein palmitoylation [Evidence IMP] [PMID 16751107]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 16227572]; GO_process: GO:0030100 - regulation of endocytosis [Evidence IMP] [PMID 10866691]; GO_process: GO:0010969 - regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI] [PMID 8524293]
AWJ20_2564	Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004733 - pyridoxamine-phosphate oxidase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0042823 - pyridoxal phosphate biosynthetic process [Evidence IEA]
AWJ20_2565	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IPI] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12768207]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IGI] [PMID 12730134]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12768207]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]
AWJ20_2566	Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 205532]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_function: GO:0004042 - acetyl-CoA:L-glutamate N-acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004042 - acetyl-CoA:L-glutamate N-acetyltransferase activity [Evidence IDA,IMP] [PMID 11553611]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence TAS] [PMID 11553611]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006592 - ornithine biosynthetic process [Evidence IMP] [PMID 11553611]
AWJ20_2567	AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 9606181]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 16601096]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA,IMP] [PMID 9606181]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 16505166]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 9155008]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 9606181]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 18266866]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 9211789]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP,IPI] [PMID 9606181]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP] [PMID 16505166]; GO_process: GO:0051260 - protein homooligomerization [Evidence IDA] [PMID 9606181]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0016125 - sterol metabolic process [Evidence IGI,IMP] [PMID 16096648]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2570	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
AWJ20_2572	Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 18946089]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 10207081]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17717527]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 18946089]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000145 - exocyst [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 18195105]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17717527]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IPI] [PMID 10207081]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IDA] [PMID 10588647]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IPI] [PMID 19955214]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 17717527]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 17339375]; GO_process: GO:0007266 - Rho protein signal transduction [Evidence IDA,IGI,IPI] [PMID 19955214]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 15583030]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 18946089]; GO_process: GO:0051601 - exocyst localization [Evidence IGI] [PMID 17717527]; GO_process: GO:0051601 - exocyst localization [Evidence IGI] [PMID 18946089]; GO_process: GO:0006887 - exocytosis [Evidence IEA,IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 15583030]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 17339375]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17717527]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
AWJ20_2574	Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10635561]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006486 - protein glycosylation [Evidence IDA,IMP] [PMID 10635561]
AWJ20_2577	GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2580	Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11747810]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 19129178]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 1918080]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11747810]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 1918080]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11914276]; GO_function: GO:0008061 - chitin binding [Evidence IEA]; GO_function: GO:0004568 - chitinase activity [Evidence IEA,IEA]; GO_function: GO:0008843 - endochitinase activity [Evidence IDA] [PMID 6799506]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IC] [PMID 3033651]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 1918080]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]
AWJ20_2581	S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 21858014]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0008112 - nicotinamide N-methyltransferase activity [Evidence IEA]; GO_function: GO:0008112 - nicotinamide N-methyltransferase activity [Evidence ISS] [PMID 12736687]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 12736687]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006769 - nicotinamide metabolic process [Evidence ISS] [PMID 12736687]; GO_process: GO:0006769 - nicotinamide metabolic process [Evidence IGI] [PMID 14724176]
AWJ20_2582	Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, is able to complement a yeast coq2 null mutant; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 359053]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10469659]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1740455]; GO_function: GO:0002083 - 4-hydroxybenzoate decaprenyltransferase activity [Evidence IEA]; GO_function: GO:0047293 - 4-hydroxybenzoate nonaprenyltransferase activity [Evidence IEA]; GO_function: GO:0008412 - 4-hydroxybenzoate octaprenyltransferase activity [Evidence IMP] [PMID 1740455]; GO_function: GO:0008412 - 4-hydroxybenzoate octaprenyltransferase activity [Evidence IGI] [PMID 7765507]; GO_function: GO:0008412 - 4-hydroxybenzoate octaprenyltransferase activity [Evidence ISS] [PMID 8155731]; GO_function: GO:0004659 - prenyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IGI] [PMID 15548532]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 1740455]
AWJ20_2583	Protein required for biogenesis of the large ribosomal subunit; required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein; essential gene; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 19806183]
AWJ20_2585	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 9920864]; GO_process: GO:1902047 - polyamine transmembrane transport [Evidence IMP] [PMID 24136413]; GO_process: GO:0015847 - putrescine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2586	TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA,IPI] [PMID 12501245]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2587	Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10790377]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003963 - RNA-3'-phosphate cyclase activity [Evidence ISS] [PMID 10790377]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 21849504]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 16307926]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10790377]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10790377]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10790377]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
AWJ20_2588	Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 7862158]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21954159]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 7862158]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2589	Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 15102831]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
AWJ20_2590	Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11311123]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9563516]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11311123]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9563516]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004396 - hexokinase activity [Evidence IEA,IEA]; GO_function: GO:0004396 - hexokinase activity [Evidence IDA] [PMID 12611889]; GO_function: GO:0004396 - hexokinase activity [Evidence IDA] [PMID 332086]; GO_function: GO:0004396 - hexokinase activity [Evidence IMP] [PMID 6341351]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0032445 - fructose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006000 - fructose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0046323 - glucose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IDA] [PMID 332086]; GO_process: GO:0006096 - glycolytic process [Evidence IDA,IMP] [PMID 8917466]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEA]; GO_process: GO:0006013 - mannose metabolic process [Evidence IDA] [PMID 332086]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0046015 - regulation of transcription by glucose [Evidence IDA] [PMID 11311123]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 15722108]
AWJ20_2591	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10848632]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 12446794]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IDA,IGI,IMP] [PMID 7493987]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IMP] [PMID 12399373]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 7493987]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 8422683]; GO_process: GO:1900008 - negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging [Evidence IMP] [PMID 15020466]; GO_process: GO:0001079 - nitrogen catabolite regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11687605]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA,IGI,IMP] [PMID 7493987]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8422683]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP] [PMID 10848632]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP] [PMID 11076970]
AWJ20_2592	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 12499351]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15039776]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 15039776]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 9199164]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005771 - multivesicular body [Evidence IMP] [PMID 14523026]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15623581]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15707981]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 6759873]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 15707981]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 6759873]; GO_process: GO:0015846 - polyamine transport [Evidence IMP] [PMID 15707981]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2593	Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2594	Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 3275644]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 3275644]; GO_function: GO:0003852 - 2-isopropylmalate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003852 - 2-isopropylmalate synthase activity [Evidence IDA] [PMID 3275644]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0046912 - transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IGI] [PMID 10790691]
AWJ20_2595	Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IPI] [PMID 14690608]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 15485911]; GO_process: GO:0043486 - histone exchange [Evidence IMP] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2596	Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA,IMP] [PMID 11238450]; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 22761830]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 8707815]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA,IMP] [PMID 11238450]
AWJ20_2597	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; G protein of the Ras superfamily, similar to ADP-ribosylation factor; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15077113]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15564045]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15975906]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 15975906]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 23345439]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,ISS] [PMID 9388248]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 16926193]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12210899]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IMP] [PMID 11840166]
AWJ20_2598	Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 14998369]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 1986244]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0004096 - catalase activity [Evidence IEA,IEA]; GO_function: GO:0004096 - catalase activity [Evidence IGI,IMP] [PMID 3897793]; GO_function: GO:0004096 - catalase activity [Evidence IDA] [PMID 9931255]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_process: GO:0001315 - age-dependent response to reactive oxygen species [Evidence IGI,IMP] [PMID 10705040]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IEA]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IGI,IMP] [PMID 3897793]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IDA] [PMID 9931255]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]; GO_process: GO:0000302 - response to reactive oxygen species [Evidence IMP] [PMID 15893481]
AWJ20_2599	XP_964639|NADPH dehydrogenase [Neurospora crassa OR74A]
AWJ20_2600	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
AWJ20_2601	Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004163 - diphosphomevalonate decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004163 - diphosphomevalonate decarboxylase activity [Evidence IDA,IMP] [PMID 15169949]; GO_function: GO:0004163 - diphosphomevalonate decarboxylase activity [Evidence IMP] [PMID 1779710]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway [Evidence IEA]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IMP] [PMID 9244250]
AWJ20_2602	Plasma membrane H+-ATPase; pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 10716729]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 15536122]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11739806]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0008553 - hydrogen-exporting ATPase activity, phosphorylative mechanism [Evidence IEA]; GO_function: GO:0008553 - hydrogen-exporting ATPase activity, phosphorylative mechanism [Evidence IDA] [PMID 17912695]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:1902906 - proteasome storage granule assembly [Evidence IMP] [PMID 23690178]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IDA] [PMID 8396147]; GO_process: GO:0006885 - regulation of pH [Evidence IEP] [PMID 8929277]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 8396147]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2603	Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_2604	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 20732871]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 23109428]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 20732871]; GO_process: GO:0080182 - histone H3-K4 trimethylation [Evidence IMP] [PMID 20732871]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14710186]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 11927560]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2605	Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000321 - re-entry into mitotic cell cycle after pheromone arrest [Evidence IMP] [PMID 16510898]
AWJ20_2606	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bateria; TDH3 has a paralog, TDH2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11158358]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11158358]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IPI] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004365 - glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Evidence IEA]; GO_function: GO:0004365 - glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Evidence IDA] [PMID 3905788]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17726063]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEP] [PMID 3905788]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEP] [PMID 3905788]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0072593 - reactive oxygen species metabolic process [Evidence IMP] [PMID 17726063]
AWJ20_2607	Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IDA] [PMID 10855721]; GO_process: GO:0006083 - acetate metabolic process [Evidence IDA] [PMID 10855721]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]
AWJ20_2609	Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2610	TFIID subunit (67 kDa); involved in RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2611	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; GO_component: GO:0034245 - mitochondrial DNA-directed RNA polymerase complex [Evidence IDA] [PMID 7929382]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 12270918]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 12270918]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0034246 - mitochondrial RNA polymerase binding promoter specificity activity [Evidence IDA] [PMID 20008320]; GO_function: GO:0034246 - mitochondrial RNA polymerase binding promoter specificity activity [Evidence IDA,IPI] [PMID 7929382]; GO_function: GO:0000179 - rRNA (adenine-N6,N6-)-dimethyltransferase activity [Evidence IEA]; GO_function: GO:0008649 - rRNA methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IEA]; GO_process: GO:0000154 - rRNA modification [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006391 - transcription initiation from mitochondrial promoter [Evidence IDA] [PMID 19920143]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2612	DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 8889513]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA,IPI,ISS] [PMID 8889513]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009063 - cellular amino acid catabolic process [Evidence IGI,IMP] [PMID 8889513]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IMP] [PMID 8889513]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_2614	RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23028530]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23028530]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI] [PMID 23028530]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI] [PMID 23028530]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]
AWJ20_2618	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA] [PMID 20308326]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12482986]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12558798]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2620	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11027292]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA,IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11027292]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IGI,IMP] [PMID 11027292]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IGI,IMP] [PMID 19060898]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 11910110]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_2621	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 9920864]; GO_process: GO:1902047 - polyamine transmembrane transport [Evidence IMP] [PMID 24136413]; GO_process: GO:0015847 - putrescine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2622	Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15282802]; GO_component: GO:0032174 - cellular bud neck septin collar [Evidence IDA] [PMID 15901837]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15901837]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 15901837]; GO_component: GO:0005940 - septin ring [Evidence IDA,IPI] [PMID 9314530]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12529424]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9314530]; GO_process: GO:0008105 - asymmetric protein localization [Evidence IDA,IMP] [PMID 12529424]; GO_process: GO:0000917 - barrier septum assembly [Evidence IGI] [PMID 15470103]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IGI,IMP] [PMID 15470103]
AWJ20_2624	Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 20124025]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 20124025]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IMP] [PMID 19562342]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000963 - mitochondrial RNA processing [Evidence IMP] [PMID 19562342]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 19751518]; GO_process: GO:0016072 - rRNA metabolic process [Evidence IMP] [PMID 20124025]
AWJ20_2626	Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 15507444]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11498004]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 11498004]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8702496]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP] [PMID 11498004]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP] [PMID 15507444]
AWJ20_2627	Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16857587]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9711835]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19618123]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16857587]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19618123]; GO_function: GO:0016208 - AMP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003987 - acetate-CoA ligase activity [Evidence IEA,IEA]; GO_function: GO:0003987 - acetate-CoA ligase activity [Evidence IDA] [PMID 8910545]; GO_function: GO:0016880 - acid-ammonia (or amide) ligase activity [Evidence IDA] [PMID 18305111]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006085 - acetyl-CoA biosynthetic process [Evidence IDA] [PMID 8910545]; GO_process: GO:0019427 - acetyl-CoA biosynthetic process from acetate [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 16857587]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 19618123]
AWJ20_2628	Putative transcription factor; has homolog in Kluyveromyces lactis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_2629	Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
AWJ20_2631	rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 21282979]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17425675]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 21282979]; GO_function: GO:0030515 - snoRNA binding [Evidence IDA] [PMID 21893585]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IGI] [PMID 17425675]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2632	Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12455994]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12455994]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8167411]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 12455994]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8167411]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 8167411]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12455994]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8167411]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 23906065]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11591390]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 22323294]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 23468594]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10066831]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 11003652]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IMP] [PMID 11595741]; GO_process: GO:0045921 - positive regulation of exocytosis [Evidence IGI,IPI] [PMID 19955214]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 10066831]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IMP] [PMID 12234925]; GO_process: GO:0060178 - regulation of exocyst localization [Evidence IMP] [PMID 11595741]; GO_process: GO:0031384 - regulation of initiation of mating projection growth [Evidence IMP] [PMID 14734532]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0031106 - septin ring organization [Evidence IMP] [PMID 14517318]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_2633	Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISA] [PMID 23267056]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:1990022 - RNA polymerase III complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IMP] [PMID 18439903]
AWJ20_2635	Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10681558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP,ISS] [PMID 10681558]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 10681558]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0010038 - response to metal ion [Evidence IMP] [PMID 12270680]
AWJ20_2638	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene; GO_component: GO:0030121 - AP-1 adaptor complex [Evidence IPI] [PMID 16687571]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 16687571]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IGI,IMP] [PMID 16687571]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2639	Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); encodes ortholog of mammalian endoG; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 17244531]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 3286639]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17244531]; GO_function: GO:0004520 - endodeoxyribonuclease activity [Evidence IDA] [PMID 3286639]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004529 - exodeoxyribonuclease activity [Evidence IDA] [PMID 3286639]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0004540 - ribonuclease activity [Evidence IDA] [PMID 3286639]; GO_process: GO:0006308 - DNA catabolic process [Evidence IDA] [PMID 3286639]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 8087883]; GO_process: GO:0006401 - RNA catabolic process [Evidence IDA] [PMID 3286639]; GO_process: GO:0006309 - apoptotic DNA fragmentation [Evidence IMP] [PMID 22727375]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17244531]
AWJ20_2645	Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10077572]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IEA]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IDA] [PMID 10600176]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 10077572]
AWJ20_2649	DNA helicase/Ubiquitin ligase; involved in error-free branch of DNA damage tolerance (DDT) pathway; proposed to promote replication fork regression during postreplication repair by template switching; stimulates synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress; associates with native telomeres, cooperates with homologous recombination in senescent cells; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IDA] [PMID 24393774]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10880451]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 17936713]; GO_function: GO:0000403 - Y-form DNA binding [Evidence IDA] [PMID 17936713]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 17936713]; GO_function: GO:0009378 - four-way junction helicase activity [Evidence IDA] [PMID 17936713]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI,IMP] [PMID 16224103]; GO_process: GO:0042276 - error-prone translesion synthesis [Evidence IMP] [PMID 23142547]; GO_process: GO:0010994 - free ubiquitin chain polymerization [Evidence IDA] [PMID 19706603]; GO_process: GO:0006301 - postreplication repair [Evidence IDA] [PMID 17936713]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA] [PMID 19706603]
AWJ20_2650	Mucin family member that functions as an osmosensor in the HOG pathway; functions in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,ISS] [PMID 8550469]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 17627274]; GO_function: GO:0005034 - osmosensor activity [Evidence IGI] [PMID 17627274]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 8550469]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 8550469]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 8550469]; GO_process: GO:0006972 - hyperosmotic response [Evidence IGI] [PMID 17627274]; GO_process: GO:0007232 - osmosensory signaling pathway via Sho1 osmosensor [Evidence IGI,IPI] [PMID 17627274]
AWJ20_2656	Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 16373354]; GO_component: GO:0017177 - glucosidase II complex [Evidence IPI] [PMID 16373354]; GO_function: GO:0004558 - alpha-glucosidase activity [Evidence IMP] [PMID 16373354]; GO_function: GO:0004558 - alpha-glucosidase activity [Evidence IMP] [PMID 19542522]; GO_process: GO:0006491 - N-glycan processing [Evidence IEA]; GO_process: GO:0000271 - polysaccharide biosynthetic process [Evidence IMP] [PMID 16373354]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 16373354]
AWJ20_2658	RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA,IMP] [PMID 2251118]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA,IMP] [PMID 8112302]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA,IMP] [PMID 8430102]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 1534753]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IDA] [PMID 8943336]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0034247 - snoRNA splicing [Evidence IMP] [PMID 24442613]
AWJ20_2659	Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN; GO_component: GO:0008180 - COP9 signalosome [Evidence IDA] [PMID 21289098]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IDA] [PMID 21289098]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0010388 - cullin deneddylation [Evidence IMP] [PMID 21289098]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 8982460]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence TAS] [PMID 9697412]
AWJ20_2660	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IDA,ISS] [PMID 7836424]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0018548 - pentaerythritol trinitrate reductase activity [Evidence IEA]; GO_function: GO:0052690 - trichloro-p-hydroquinone reductive dehalogenase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17897954]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2662	Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript; Small Subunit processome is also known as SSU processome; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2663	RNA polymerase III subunit C82; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 1406632]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2665	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2666	hypothetical protein; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 15651983]; GO_component: GO:0005938 - cell cortex [Evidence IEA]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 12388763]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 15651983]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 18298676]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18298676]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI] [PMID 12388763]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 12388763]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 10512884]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 12388763]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]
AWJ20_2667	RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0032549 - ribonucleoside binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 2406558]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2668	Nuclear envelope protein that mediates the nuclear export of Srp1p; Srp1p (importin alpha) is a homolog of metazoan CAS protein; required for accurate chromosome segregation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 9857050]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008262 - importin-alpha export receptor activity [Evidence IGI,IPI,ISS] [PMID 9857050]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IGI,IPI] [PMID 9857050]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2669	Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_2670	Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2671	Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 15585575]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 15585575]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0097038 - perinuclear endoplasmic reticulum [Evidence IDA] [PMID 15585575]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 22685415]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 15585575]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IGI,IMP] [PMID 17984322]; GO_process: GO:0036228 - protein targeting to nuclear inner membrane [Evidence IMP] [PMID 15911569]; GO_process: GO:0000921 - septin ring assembly [Evidence IGI,IMP] [PMID 17984322]
AWJ20_2672	Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 20528918]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20528918]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IPI] [PMID 20528918]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 20884785]; GO_function: GO:0034511 - U3 snoRNA binding [Evidence IDA] [PMID 20528918]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 20528918]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 20528918]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 20884785]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP,IPI] [PMID 19806183]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 20528918]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 20884785]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2673	Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IDA] [PMID 10574934]; GO_function: GO:0004301 - epoxide hydrolase activity [Evidence IDA] [PMID 10574934]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004463 - leukotriene-A4 hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004463 - leukotriene-A4 hydrolase activity [Evidence ISS] [PMID 10341423]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 10341423]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IDA] [PMID 10574934]; GO_process: GO:0019370 - leukotriene biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IDA] [PMID 10574934]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_2675	Phosphoribosylpyrophosphate amidotransferase (PRPPAT); catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; also known as amidophosphoribosyltransferase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004044 - amidophosphoribosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004044 - amidophosphoribosyltransferase activity [Evidence IDA,IMP] [PMID 11689683]; GO_function: GO:0004044 - amidophosphoribosyltransferase activity [Evidence IMP] [PMID 6376509]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 11689683]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]
AWJ20_2678	Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2679	C-8 sterol isomerase; catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IC] [PMID 18459942]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000247 - C-8 sterol isomerase activity [Evidence IMP] [PMID 18459942]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 18459942]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
AWJ20_2680	Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9224714]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 12101232]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 9858534]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 7713415]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 12101232]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 9858534]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2682	ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IPI] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 16168371]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0034099 - luminal surveillance complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0070492 - oligosaccharide binding [Evidence IDA] [PMID 19111666]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16168370]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16168371]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16168372]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22298424]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 22298424]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 24292014]
AWJ20_2683	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]
AWJ20_2686	AAA ATPase and SNARE disassembly chaperone; required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian N-ethylmaleimide-sensitive factor (NSF); GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 23613772]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 10387016]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 2071670]; GO_process: GO:0048211 - Golgi vesicle docking [Evidence IDA] [PMID 9382859]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IDA] [PMID 18650938]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IDA] [PMID 9425154]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 11694599]; GO_process: GO:0048219 - inter-Golgi cisterna vesicle-mediated transport [Evidence IMP] [PMID 10637300]; GO_process: GO:0048219 - inter-Golgi cisterna vesicle-mediated transport [Evidence IMP] [PMID 2071670]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 8670830]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 9685264]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IDA] [PMID 9382859]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_2688	Fungal Genetics Stock Center 13762
AWJ20_2692	Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005751 - mitochondrial respiratory chain complex IV [Evidence IPI] [PMID 1331058]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IDA] [PMID 1331058]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IDA] [PMID 7851399]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 17215247]; GO_process: GO:0009060 - aerobic respiration [Evidence IPI] [PMID 163235]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen [Evidence IDA] [PMID 1331058]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006119 - oxidative phosphorylation [Evidence IEA]
AWJ20_2693	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2694	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 14729968]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 16024655]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IPI] [PMID 15870268]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 12024034]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IMP] [PMID 14729968]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2695	Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 19129178]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_component: GO:0005773 - vacuole [Evidence IDA] [PMID 23222640]; GO_function: GO:0015926 - glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IGI] [PMID 9748433]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2696	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004755 - saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity [Evidence IEA]; GO_function: GO:0004755 - saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity [Evidence IDA] [PMID 18416559]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 6429126]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2699	Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA,IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 12045225]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IGI,IMP] [PMID 18694928]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IDA] [PMID 23919454]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006037 - cell wall chitin metabolic process [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0071555 - cell wall organization [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 18694928]
AWJ20_2701	Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to the M28 family of metalloproteases; has a lumenal-facing protease domain; proposed role in vacuole physiology; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23679341]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_2703	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IPI] [PMID 8576246]; GO_function: GO:0051082 - unfolded protein binding [Evidence ISS] [PMID 8576246]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IGI,IMP] [PMID 9199338]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_2704	Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004853 - uroporphyrinogen decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004853 - uroporphyrinogen decarboxylase activity [Evidence IDA] [PMID 2180703]; GO_function: GO:0004853 - uroporphyrinogen decarboxylase activity [Evidence IMP] [PMID 7035824]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 14559249]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 1471989]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]
AWJ20_2705	hypothetical protein; similar to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae; expresses a circular RNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence ISS] [PMID 15225602]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]
AWJ20_2707	Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 14981506]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14981506]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14981507]; GO_function: GO:0019904 - protein domain specific binding [Evidence IDA] [PMID 16105940]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP,IPI] [PMID 14981506]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP,IPI] [PMID 14981507]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2710	Cytoplasmic protein required for correct processing of 20S pre-rRNA; protein required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IMP] [PMID 19806183]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_2711	Mitochondrial translation initiation factor 2; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 1935960]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 12729623]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 12729623]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 15935987]; GO_function: GO:0003743 - translation initiation factor activity [Evidence ISA] [PMID 1935960]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 1935960]; GO_process: GO:0070124 - mitochondrial translational initiation [Evidence IC] [PMID 15935987]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence ISA] [PMID 1935960]
AWJ20_2712	GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2714	Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2715	Putative kinase with similarity to the PRK/URK/PANK kinase subfamily; the PRK/URK/PANK subfamily of P-loop kinases is also known as phosphoribulokinase/uridine kinase/bacterial pantothenate kinase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 18004758]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence ISS] [PMID 18004758]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence ISS] [PMID 18004758]
AWJ20_2717	Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2718	Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 205532]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003992 - N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [Evidence IEA]; GO_function: GO:0003992 - N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [Evidence IDA] [PMID 2199330]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence TAS] [PMID 12603335]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006592 - ornithine biosynthetic process [Evidence TAS] [PMID 205532]
AWJ20_2720	Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0047389 - glycerophosphocholine phosphodiesterase activity [Evidence IMP,ISS] [PMID 16141200]; GO_function: GO:0008889 - glycerophosphodiester phosphodiesterase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA]; GO_process: GO:0046475 - glycerophospholipid catabolic process [Evidence IMP,ISS] [PMID 16141200]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
AWJ20_2722	ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL; GO_component: GO:0032389 - MutLalpha complex [Evidence IEA]; GO_component: GO:0032389 - MutLalpha complex [Evidence IPI] [PMID 10570173]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 10938116]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 11717305]; GO_function: GO:0032135 - DNA insertion or deletion binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0032139 - dinucleotide insertion or deletion binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 11575920]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IDA] [PMID 9368761]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 11575920]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 2685551]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IBA]
AWJ20_2723	Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IDA] [PMID 8202350]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12912927]; GO_component: GO:0031389 - Rad17 RFC-like complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23613772]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 12604797]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 8995429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0017076 - purine nucleotide binding [Evidence ISS] [PMID 7651383]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IMP] [PMID 9671499]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1346062]; GO_process: GO:0006298 - mismatch repair [Evidence TAS] [PMID 10072354]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IPI] [PMID 11389843]
AWJ20_2724	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12773575]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 12773575]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 16209721]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 10669874]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 10669874]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 20670889]; GO_process: GO:0000054 - ribosomal subunit export from nucleus [Evidence IMP,IPI] [PMID 12773575]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2725	Essential SNARE protein localized to the ER; involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p; GO_component: GO:0031201 - SNARE complex [Evidence IDA,ISM] [PMID 12853481]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0071458 - integral component of cytoplasmic side of endoplasmic reticulum membrane [Evidence IDA] [PMID 12893879]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence ISA] [PMID 12853481]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 12853481]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 12893879]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048279 - vesicle fusion with endoplasmic reticulum [Evidence IC] [PMID 12853481]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_2728	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000796 - condensin complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IGI,ISS] [PMID 10749931]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IGI] [PMID 11864994]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA]; GO_process: GO:0010032 - meiotic chromosome condensation [Evidence IMP] [PMID 14662740]; GO_process: GO:0051307 - meiotic chromosome separation [Evidence IMP] [PMID 14662740]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IGI] [PMID 10749931]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 11864994]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 11864994]; GO_process: GO:0070550 - rDNA condensation [Evidence IMP] [PMID 18708580]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IMP] [PMID 14662740]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
AWJ20_2729	Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030061 - mitochondrial crista [Evidence IDA] [PMID 19019989]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IMP] [PMID 3028797]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 3028797]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IDA] [PMID 3028797]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_2730	Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome; GO_component: GO:0055087 - Ski complex [Evidence IDA] [PMID 10744028]; GO_component: GO:0055087 - Ski complex [Evidence IDA,IPI] [PMID 18042677]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051607 - defense response to virus [Evidence IEA]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 10611222]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 11910110]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 17660569]
AWJ20_2731	Fungal Genetics Stock Center 13768
AWJ20_2732	DNA ligase found in the nucleus and mitochondria; an essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IMP] [PMID 10531002]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10531002]; GO_component: GO:0005657 - replication fork [Evidence NAS] [PMID 9759502]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IEA,IEA]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA] [PMID 1445910]; GO_function: GO:0003910 - DNA ligase (ATP) activity [Evidence IDA] [PMID 6347688]; GO_function: GO:0003909 - DNA ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006266 - DNA ligation [Evidence IDA,IMP] [PMID 9759502]; GO_process: GO:0051103 - DNA ligation involved in DNA repair [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 9230305]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IMP] [PMID 10052932]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006273 - lagging strand elongation [Evidence IDA,IMP] [PMID 9759502]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IMP] [PMID 16079237]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IMP] [PMID 6749599]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 10052932]
AWJ20_2734	Protein phosphatase required for mitotic exit; required for rDNA segregation; located in nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis; GO_component: GO:0030869 - RENT complex [Evidence IDA] [PMID 10219244]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12062061]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12062061]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA] [PMID 24319056]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA] [PMID 9295359]; GO_function: GO:0004725 - protein tyrosine phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0008138 - protein tyrosine/serine/threonine phosphatase activity [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051304 - chromosome separation [Evidence IMP] [PMID 16769819]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0051229 - meiotic spindle disassembly [Evidence IMP] [PMID 12737806]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IMP] [PMID 6749599]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0035335 - peptidyl-tyrosine dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 20923974]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 9295359]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IGI,IPI] [PMID 10219244]
AWJ20_2735	Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9988704]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031235 - intrinsic component of the cytoplasmic side of the plasma membrane [Evidence IDA] [PMID 17679730]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IMP] [PMID 9660783]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0005324 - long-chain fatty acid transporter activity [Evidence IMP] [PMID 9079682]; GO_function: GO:0031957 - very long-chain fatty acid-CoA ligase activity [Evidence IMP] [PMID 9660783]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0015909 - long-chain fatty acid transport [Evidence IMP] [PMID 10880966]; GO_process: GO:0015909 - long-chain fatty acid transport [Evidence IGI,IMP] [PMID 12601005]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0000038 - very long-chain fatty acid metabolic process [Evidence IMP] [PMID 9660783]; GO_process: GO:0000038 - very long-chain fatty acid metabolic process [Evidence IMP] [PMID 9988704]
AWJ20_2736	Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 4355481]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IDA] [PMID 3071718]; GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase activity [Evidence IMP] [PMID 6297759]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IMP] [PMID 23642236]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IMP] [PMID 6297759]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2740	N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8183942]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA,IMP] [PMID 8183942]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2741	Essential RNA-binding G protein effector of mating response pathway; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23222640]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 11278502]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 8533468]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 11278502]; GO_function: GO:0001965 - G-protein alpha-subunit binding [Evidence IPI] [PMID 14536090]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 11278502]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16632467]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI,IMP] [PMID 16632467]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8533468]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IPI] [PMID 11278502]; GO_process: GO:0045141 - meiotic telomere clustering [Evidence IMP] [PMID 16632467]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IGI] [PMID 14536090]
AWJ20_2742	Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISA] [PMID 16845689]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IMP] [PMID 16845689]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015856 - cytosine transport [Evidence IMP] [PMID 16845689]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0072530 - purine-containing compound transmembrane transport [Evidence ISA] [PMID 16845689]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2743	Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0004409 - homoaconitate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0004409 - homoaconitate hydratase activity [Evidence ISA] [PMID 9268014]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 2507177]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2744	Putative transcription factor; has homolog in Kluyveromyces lactis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_2745	Protein required for the transport of Gap1p; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 12631735]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12631735]; GO_function: GO:0030295 - protein kinase activator activity [Evidence IMP] [PMID 16002396]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 12719473]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 12408816]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 12719473]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 11742997]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 12719473]; GO_process: GO:0006810 - transport [Evidence IMP] [PMID 9409822]
AWJ20_2746	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16043493]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 9268361]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 23390378]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12881429]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 15388879]
AWJ20_2747	Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11327310]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 18180296]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19564484]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 19564484]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA] [PMID 23940037]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 12220683]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 23940037]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 23940037]
AWJ20_2750	Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IC] [PMID 9643541]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 19767828]
AWJ20_2751	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP); GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11598205]; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11733065]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11733065]; GO_function: GO:0031593 - polyubiquitin binding [Evidence IDA] [PMID 16004872]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 16004872]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11740563]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11813000]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11739805]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18812321]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11598205]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11733065]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20206597]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11740563]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11813000]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_2756	Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 9756928]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9756928]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9756928]
AWJ20_2758	Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003939 - L-iditol 2-dehydrogenase activity [Evidence IEA]; GO_function: GO:0003939 - L-iditol 2-dehydrogenase activity [Evidence IDA,ISS] [PMID 8125328]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEP] [PMID 8125328]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2762	3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence ISM] [PMID 1551874]; GO_function: GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase activity [Evidence IDA] [PMID 1551874]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004300 - enoyl-CoA hydratase activity [Evidence IDA] [PMID 1551874]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 10497229]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 1551874]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2763	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2764	Fungal Genetics Stock Center 12727
AWJ20_2766	hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_2767	Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans; GO_component: GO:0036266 - Cdc48p-Npl4p-Vms1p AAA ATPase complex [Evidence IDA] [PMID 21070972]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 21070972]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 21148305]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 21070972]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21148305]; GO_process: GO:0072671 - mitochondria-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21070972]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22718752]
AWJ20_2768	DNA-dependent ATPase; DNA recombination/repair translocase, supercoils DNA and promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational repair of DNA double-strand breaks (DSBs) during mitosis and meiosis; phosphorylated in Mec1p-, Rad53p-dependent way in response to one DSB; contributes to remodelling of nucleosomes; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 16831867]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 10970884]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 10970884]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IMP] [PMID 16831867]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA,IMP] [PMID 16831867]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IDA,IMP] [PMID 16831867]; GO_process: GO:0032392 - DNA geometric change [Evidence IDA] [PMID 10970884]; GO_process: GO:0032392 - DNA geometric change [Evidence IDA,IMP] [PMID 16831867]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 16831867]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 16831867]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0030491 - heteroduplex formation [Evidence IDA] [PMID 10970884]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0045144 - meiotic sister chromatid segregation [Evidence IMP] [PMID 16230461]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI,IMP] [PMID 9409819]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI,IMP] [PMID 9409820]
AWJ20_2769	Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein; RTA1 has a paralog, YLR046C, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12524434]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 8660468]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22129104]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_2770	Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 18675371]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11533229]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 18675371]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 16055745]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11533229]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16055745]; GO_process: GO:0035969 - positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 11208779]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2771	Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; GO_component: GO:0030428 - cell septum [Evidence IDA] [PMID 12455695]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence ISS] [PMID 11747810]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11935221]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence IGI] [PMID 12455695]; GO_function: GO:0052861 - glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group [Evidence IEA,IEA]; GO_function: GO:0052862 - glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0016998 - cell wall macromolecule catabolic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IEP,ISS] [PMID 11747810]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 16328626]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2772	Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0000784 - nuclear chromosome, telomeric region [Evidence IDA] [PMID 20513435]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 20513435]; GO_function: GO:0000982 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [Evidence IDA] [PMID 20513435]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0043035 - chromatin insulator sequence binding [Evidence IDA] [PMID 11258704]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 20513435]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IDA] [PMID 11258704]; GO_process: GO:0032211 - negative regulation of telomere maintenance via telomerase [Evidence IGI] [PMID 16467854]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001015 - snoRNA transcription from an RNA polymerase II promoter [Evidence IDA,IMP] [PMID 20513435]; GO_process: GO:0010833 - telomere maintenance via telomere lengthening [Evidence IDA] [PMID 17917674]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2773	Biotin synthase; catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0004076 - biotin synthase activity [Evidence IEA,IEA]; GO_function: GO:0004076 - biotin synthase activity [Evidence IMP] [PMID 10525840]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IMP] [PMID 10525840]
AWJ20_2775	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_2776	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; YPS1 has a paralog, MKC7, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA] [PMID 8389368]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0016485 - protein processing [Evidence IDA] [PMID 8626758]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_2779	Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016868 - intramolecular transferase activity, phosphotransferases [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004610 - phosphoacetylglucosamine mutase activity [Evidence IEA,IEA]; GO_function: GO:0004610 - phosphoacetylglucosamine mutase activity [Evidence IMP,ISS] [PMID 8174553]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IBA]; GO_process: GO:0006048 - UDP-N-acetylglucosamine biosynthetic process [Evidence IBA,IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 8174553]; GO_process: GO:0019255 - glucose 1-phosphate metabolic process [Evidence IBA]
AWJ20_2782	Cytoplasmic hypothetical protein; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_2785	ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004781 - sulfate adenylyltransferase (ATP) activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004781 - sulfate adenylyltransferase (ATP) activity [Evidence IDA] [PMID 10092498]; GO_function: GO:0004781 - sulfate adenylyltransferase (ATP) activity [Evidence IMP] [PMID 197388]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0000103 - sulfate assimilation [Evidence IEA,IEA]; GO_process: GO:0019379 - sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence IMP] [PMID 197388]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IEA]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IMP] [PMID 1101032]
AWJ20_2788	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11113180]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11113180]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 10580002]; GO_process: GO:0000173 - inactivation of MAPK activity involved in osmosensory signaling pathway [Evidence IDA,IGI,IMP] [PMID 11113180]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IMP] [PMID 9529388]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 20400943]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 10580002]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 11113180]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IMP] [PMID 8196609]
AWJ20_2789	Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA] [PMID 12393914]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IDA,IPI] [PMID 2481228]; GO_component: GO:0031588 - AMP-activated protein kinase complex [Evidence IPI] [PMID 9121458]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17237508]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 2481228]; GO_component: GO:0005641 - nuclear envelope lumen [Evidence IDA] [PMID 17237508]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17237508]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 2481228]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562756]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 11486005]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IGI,IMP] [PMID 2557546]; GO_function: GO:0004679 - AMP-activated protein kinase activity [Evidence IMP] [PMID 7913470]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043539 - protein serine/threonine kinase activator activity [Evidence IMP] [PMID 11486005]; GO_function: GO:0043539 - protein serine/threonine kinase activator activity [Evidence IGI,IMP] [PMID 2557546]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IMP] [PMID 1355328]; GO_process: GO:0045722 - positive regulation of gluconeogenesis [Evidence IMP,IPI] [PMID 2481228]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 11486005]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 2557546]; GO_process: GO:0006468 - protein phosphorylation [Evidence IGI,IMP] [PMID 7913470]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 2557546]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 10921902]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2790	Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 1761554]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IMP] [PMID 11157982]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16413482]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16002399]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006662 - glycerol ether metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 11157982]
AWJ20_2791	Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 17261844]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 17261844]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA,IMP] [PMID 17261844]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10417390]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 17261844]; GO_process: GO:0007030 - Golgi organization [Evidence ISS] [PMID 10417390]; GO_process: GO:0009306 - protein secretion [Evidence IMP] [PMID 20156967]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_2793	Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 14645854]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IPI] [PMID 14690608]; GO_process: GO:0043486 - histone exchange [Evidence IMP] [PMID 16299513]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2794	DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12093911]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA,ISS] [PMID 12093911]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 12093911]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 12093911]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2795	Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis; GO_component: GO:0016021 - integral component of membrane [Evidence IBA,IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11251115]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IRD]; GO_component: GO:0005774 - vacuolar membrane [Evidence IDA] [PMID 23509072]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015421 - oligopeptide-transporting ATPase activity [Evidence IBA]; GO_function: GO:0015421 - oligopeptide-transporting ATPase activity [Evidence ISA] [PMID 11251115]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IDA] [PMID 23509072]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090374 - oligopeptide export from mitochondrion [Evidence ISA] [PMID 11251115]; GO_process: GO:0006857 - oligopeptide transport [Evidence ISA] [PMID 11251115]; GO_process: GO:0055085 - transmembrane transport [Evidence IBA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2797	L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0004414 - homoserine O-acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004414 - homoserine O-acetyltransferase activity [Evidence IDA,IMP] [PMID 3301801]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009092 - homoserine metabolic process [Evidence IDA,IMP] [PMID 3301801]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 6035500]; GO_process: GO:0000096 - sulfur amino acid metabolic process [Evidence IMP] [PMID 1101032]
AWJ20_2799	Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IC] [PMID 8064863]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0052909 - 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))- dimethyltransferase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence IEA]; GO_function: GO:0000179 - rRNA (adenine-N6,N6-)-dimethyltransferase activity [Evidence IEA]; GO_function: GO:0000179 - rRNA (adenine-N6,N6-)-dimethyltransferase activity [Evidence ISS] [PMID 8064863]; GO_function: GO:0008649 - rRNA methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8064863]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IEA,IEA]; GO_process: GO:0000154 - rRNA modification [Evidence IEA]; GO_process: GO:0000154 - rRNA modification [Evidence IMP] [PMID 8064863]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2800	UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016906 - sterol 3-beta-glucosyltransferase activity [Evidence IEA]; GO_function: GO:0016906 - sterol 3-beta-glucosyltransferase activity [Evidence IDA] [PMID 10224056]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0032120 - ascospore-type prospore membrane assembly [Evidence IGI] [PMID 18756268]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0030259 - lipid glycosylation [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 10224056]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2805	C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11279045]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 12119386]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003854 - 3-beta-hydroxy-delta5-steroid dehydrogenase activity [Evidence IEA]; GO_function: GO:0000252 - C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity [Evidence IDA] [PMID 9811880]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0047012 - sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 9811880]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_2806	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 12054864]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0001106 - RNA polymerase II transcription corepressor activity [Evidence IPI] [PMID 16528100]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA] [PMID 16964259]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 18381891]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15705057]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 18381891]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2807	Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2808	Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 22593576]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 3888995]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:1990077 - primosome complex [Evidence IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003896 - DNA primase activity [Evidence IEA]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 3061469]; GO_function: GO:0003896 - DNA primase activity [Evidence IDA] [PMID 3888995]; GO_function: GO:0003896 - DNA primase activity [Evidence IGI,IMP] [PMID 8436268]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 20404922]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 2023935]; GO_process: GO:0006270 - DNA replication initiation [Evidence IC] [PMID 3888995]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IEA,IEA]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IDA] [PMID 2644256]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 10025407]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 3888995]
AWJ20_2809	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IEA]; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IDA,IPI] [PMID 7828851]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 7828851]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence ISA] [PMID 16215174]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IC] [PMID 7828851]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12614847]; GO_process: GO:0043457 - regulation of cellular respiration [Evidence IGI] [PMID 7828851]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2810	Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 15591051]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0005310 - dicarboxylic acid transmembrane transporter activity [Evidence IDA] [PMID 9020177]; GO_function: GO:0005310 - dicarboxylic acid transmembrane transporter activity [Evidence IDA] [PMID 9559855]; GO_process: GO:0006835 - dicarboxylic acid transport [Evidence IDA] [PMID 9020177]; GO_process: GO:0006835 - dicarboxylic acid transport [Evidence IDA] [PMID 9559855]; GO_process: GO:0006817 - phosphate ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2811	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16900101]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 12631735]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12719473]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16900101]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10973982]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0008144 - drug binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12631735]; GO_function: GO:0004672 - protein kinase activity [Evidence IMP] [PMID 10329624]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 12719473]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 8186460]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 17698581]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 14736892]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 9096347]; GO_process: GO:0031930 - mitochondria-nucleus signaling pathway [Evidence IMP] [PMID 11997479]; GO_process: GO:0010507 - negative regulation of autophagy [Evidence IGI] [PMID 9461583]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 8741837]; GO_process: GO:0001558 - regulation of cell growth [Evidence TAS] [PMID 11057898]; GO_process: GO:0001558 - regulation of cell growth [Evidence IMP] [PMID 12171921]; GO_process: GO:0090153 - regulation of sphingolipid biosynthetic process [Evidence IMP] [PMID 23363605]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 10198052]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 8741837]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IMP] [PMID 16900101]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 8741837]
AWJ20_2812	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18723607]; GO_component: GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane [Evidence IDA] [PMID 12631735]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8846782]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10973982]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004430 - 1-phosphatidylinositol 4-kinase activity [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0008144 - drug binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12631735]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 16055732]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 12719473]; GO_process: GO:0031929 - TOR signaling [Evidence IMP] [PMID 8186460]; GO_process: GO:0030037 - actin filament reorganization involved in cell cycle [Evidence TAS] [PMID 9038344]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IMP] [PMID 9475724]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 12408816]; GO_process: GO:0010507 - negative regulation of autophagy [Evidence IGI] [PMID 9461583]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:2001108 - positive regulation of Rho guanyl-nucleotide exchange factor activity [Evidence IGI,IMP] [PMID 9038344]; GO_process: GO:0035025 - positive regulation of Rho protein signal transduction [Evidence IGI,IMP] [PMID 9038344]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0051726 - regulation of cell cycle [Evidence TAS] [PMID 9475724]; GO_process: GO:0001558 - regulation of cell growth [Evidence TAS] [PMID 11057898]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 10198052]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 8186460]
AWJ20_2813	Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17425675]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IGI] [PMID 17425675]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2814	Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23451152]; GO_component: GO:0018444 - translation release factor complex [Evidence IDA] [PMID 7556078]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003747 - translation release factor activity [Evidence IEA]; GO_function: GO:0003747 - translation release factor activity [Evidence IDA] [PMID 20947765]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IMP,IPI] [PMID 12923185]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IDA] [PMID 20947765]
AWJ20_2815	GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p); GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IDA] [PMID 8602515]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 1918143]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8195291]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8195291]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8195291]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12660244]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 15596542]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11591390]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 7962098]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 15596542]; GO_process: GO:0031532 - actin cytoskeleton reorganization [Evidence IGI,IPI] [PMID 8947028]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI,IMP] [PMID 8195291]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0090037 - positive regulation of protein kinase C signaling [Evidence IDA,IMP] [PMID 8621575]; GO_process: GO:0090037 - positive regulation of protein kinase C signaling [Evidence IGI,IPI] [PMID 8846785]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 8602514]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 8602515]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 8662910]; GO_process: GO:0060178 - regulation of exocyst localization [Evidence IMP] [PMID 11283608]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 8621575]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 10893184]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IDA] [PMID 8621575]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IGI] [PMID 8846785]
AWJ20_2816	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 15689497]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15372071]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15689497]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence TAS] [PMID 15372071]; GO_process: GO:0031929 - TOR signaling [Evidence IPI] [PMID 15689497]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 15372071]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 15689497]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IGI] [PMID 15689497]; GO_process: GO:0070941 - eisosome assembly [Evidence IGI] [PMID 21451250]; GO_process: GO:0016197 - endosomal transport [Evidence IGI] [PMID 21451250]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IPI] [PMID 15689497]; GO_process: GO:0001558 - regulation of cell growth [Evidence IGI,IPI] [PMID 15689497]
AWJ20_2819	Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 22553209]; GO_function: GO:0005525 - GTP binding [Evidence IDA,IMP] [PMID 22553209]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 22553209]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IMP] [PMID 22553209]
AWJ20_2823	Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16140254]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005342 - organic acid transmembrane transporter activity [Evidence IGI,ISS] [PMID 16140254]; GO_process: GO:0006839 - mitochondrial transport [Evidence IGI] [PMID 16140254]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI,ISS] [PMID 16140254]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2825	Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16291748]; GO_function: GO:0051724 - NAD transporter activity [Evidence IDA,IGI,IMP] [PMID 16291748]; GO_function: GO:0005477 - pyruvate secondary active transmembrane transporter activity [Evidence IMP] [PMID 12887330]; GO_function: GO:0005477 - pyruvate secondary active transmembrane transporter activity [Evidence IDA] [PMID 16291748]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 10930523]; GO_process: GO:0035352 - NAD transmembrane transport [Evidence IDA,IGI,IMP] [PMID 16291748]; GO_process: GO:0006850 - mitochondrial pyruvate transport [Evidence IMP] [PMID 12887330]; GO_process: GO:0006850 - mitochondrial pyruvate transport [Evidence IDA] [PMID 16291748]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 10930523]
AWJ20_2826	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence ISS] [PMID 11226175]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 11226175]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence ISS] [PMID 11226175]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 16134120]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 16134120]
AWJ20_2827	Inositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14699160]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 17880915]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14699160]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0052712 - inositol phosphosphingolipid phospholipase activity [Evidence IDA] [PMID 11006294]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IMP] [PMID 17880915]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IMP] [PMID 23620586]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 12180980]; GO_process: GO:0030149 - sphingolipid catabolic process [Evidence IDA] [PMID 11006294]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]
AWJ20_2829	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP); GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11598205]; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11733065]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11733065]; GO_function: GO:0031593 - polyubiquitin binding [Evidence IDA] [PMID 16004872]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 16004872]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11740563]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11813000]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11739805]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18812321]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11598205]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11733065]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20206597]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11740563]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11813000]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_2833	Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17179087]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016805 - dipeptidase activity [Evidence IEA]; GO_function: GO:0003840 - gamma-glutamyltransferase activity [Evidence IDA,IMP] [PMID 22277648]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008242 - omega peptidase activity [Evidence IGI] [PMID 17179087]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IGI] [PMID 17179087]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IMP] [PMID 17179087]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IDA,IMP] [PMID 22277648]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_2836	Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8625407]; GO_function: GO:0017022 - myosin binding [Evidence IDA] [PMID 12725728]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence TAS] [PMID 10792032]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 11553699]; GO_process: GO:0007533 - mating type switching [Evidence IMP] [PMID 8625407]
AWJ20_2838	Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity [Evidence IEA]; GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity [Evidence ISA] [PMID 15668256]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence ISA] [PMID 15668256]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2840	Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12464632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA,IMP] [PMID 12464633]; GO_function: GO:0000977 - RNA polymerase II regulatory region sequence-specific DNA binding [Evidence IDA] [PMID 20385087]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IPI] [PMID 12464633]; GO_function: GO:0001191 - RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [Evidence IMP,IPI] [PMID 20385087]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 12464633]; GO_process: GO:0071930 - negative regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17314407]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2841	Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17287526]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 15590673]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031982 - vesicle [Evidence IDA] [PMID 17287526]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 17287526]
AWJ20_2842	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9767141]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016428 - tRNA (cytosine-5-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0016428 - tRNA (cytosine-5-)-methyltransferase activity [Evidence IDA] [PMID 10445884]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 17567576]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IMP] [PMID 22760636]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 10445884]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0002127 - wobble base cytosine methylation [Evidence IMP] [PMID 22760636]
AWJ20_2843	Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10923024]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12502737]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA,IPI] [PMID 12502737]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12736301]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12736301]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP,IPI] [PMID 12502737]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2844	Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homologue, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11884586]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 11927560]; GO_component: GO:0016593 - Cdc73/Paf1 complex [Evidence IPI] [PMID 9032243]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643076]; GO_component: GO:0035327 - transcriptionally active chromatin [Evidence IDA] [PMID 11983171]; GO_function: GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding [Evidence IDA] [PMID 22796944]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 11884586]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 9032243]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IPI] [PMID 11927560]; GO_function: GO:0001089 - TFIIF-class binding transcription factor activity [Evidence IMP,IPI] [PMID 9032243]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11983171]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 15149594]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IMP] [PMID 9891041]; GO_process: GO:2001255 - positive regulation of histone H3-K36 trimethylation [Evidence IMP] [PMID 17948059]; GO_process: GO:2001165 - positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [Evidence IMP] [PMID 18469135]; GO_process: GO:2001209 - positive regulation of transcription elongation from RNA polymerase I promoter [Evidence IDA] [PMID 20299458]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 14710186]; GO_process: GO:0034402 - recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 18469135]; GO_process: GO:2001173 - regulation of histone H2B conserved C-terminal lysine ubiquitination [Evidence IDA] [PMID 19531475]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0090262 - regulation of transcription-coupled nucleotide-excision repair [Evidence IGI] [PMID 21737840]; GO_process: GO:0006362 - transcription elongation from RNA polymerase I promoter [Evidence IMP] [PMID 19164765]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 11927560]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2845	Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005770 - late endosome [Evidence IMP] [PMID 11872141]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 8163546]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 22748138]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI] [PMID 23612966]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8163546]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 22748138]; GO_process: GO:0036258 - multivesicular body assembly [Evidence IGI] [PMID 22748138]; GO_process: GO:0036010 - protein localization to endosome [Evidence IGI] [PMID 23264632]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8163546]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2847	Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 2999113]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IDA] [PMID 21321019]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IMP,ISA] [PMID 2999113]; GO_process: GO:0070159 - mitochondrial threonyl-tRNA aminoacylation [Evidence IDA] [PMID 21321019]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006435 - threonyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2849	Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12909721]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 18482875]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12912927]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 17170004]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 19430531]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence NAS] [PMID 11779788]; GO_process: GO:0010526 - negative regulation of transposition, RNA-mediated [Evidence IMP] [PMID 11779788]; GO_process: GO:0000723 - telomere maintenance [Evidence TAS] [PMID 13678589]
AWJ20_2850	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9224714]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IDA] [PMID 11485989]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IMP] [PMID 9858534]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IDA] [PMID 12072450]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IDA] [PMID 12072450]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12370284]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2852	Mitochondrial oxidoreductase; involved in mitochondrial intermembrane space import; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 15364952]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 15620710]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 15359280]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14690591]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IDA] [PMID 23834247]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IMP] [PMID 22990235]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 22990235]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 15359280]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 15364952]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IPI] [PMID 15989955]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IMP] [PMID 17336303]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2853	Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004788 - thiamine diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004788 - thiamine diphosphokinase activity [Evidence IDA] [PMID 18652651]; GO_function: GO:0004788 - thiamine diphosphokinase activity [Evidence IDA,IMP] [PMID 8394343]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009229 - thiamine diphosphate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009229 - thiamine diphosphate biosynthetic process [Evidence IMP] [PMID 8394343]; GO_process: GO:0009229 - thiamine diphosphate biosynthetic process [Evidence TAS] [PMID 9655908]
AWJ20_2857	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2858	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0003844 - 1,4-alpha-glucan branching enzyme activity [Evidence IEA,IEA]; GO_function: GO:0003844 - 1,4-alpha-glucan branching enzyme activity [Evidence IGI,IMP] [PMID 1729600]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0043169 - cation binding [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IMP] [PMID 1729600]
AWJ20_2859	Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11585823]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 11585823]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045239 - tricarboxylic acid cycle enzyme complex [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004333 - fumarate hydratase activity [Evidence IEA,IEA]; GO_function: GO:0004333 - fumarate hydratase activity [Evidence IDA] [PMID 3040736]; GO_function: GO:0016829 - lyase activity [Evidence IEA,IEA]; GO_process: GO:0006106 - fumarate metabolic process [Evidence IEA]; GO_process: GO:0006106 - fumarate metabolic process [Evidence IMP] [PMID 1587456]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IMP] [PMID 1587456]
AWJ20_2860	Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI,IMP] [PMID 9271380]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IGI,IMP] [PMID 9271380]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2861	SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IDA,IMP] [PMID 16096273]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0018027 - peptidyl-lysine dimethylation [Evidence IDA,IMP] [PMID 16096273]
AWJ20_2863	Iron-sulfur protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16162496]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16642040]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 17150819]
AWJ20_2865	Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IC] [PMID 16878994]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004378 - GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0004378 - GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [Evidence IDA] [PMID 16878994]; GO_function: GO:0033164 - glycolipid 6-alpha-mannosyltransferase activity [Evidence IDA] [PMID 16878994]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006490 - oligosaccharide-lipid intermediate biosynthetic process [Evidence IDA] [PMID 16878994]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_2866	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; relocalizes to the cytosol in response to hypoxia; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; GO_component: GO:0071819 - DUBm complex [Evidence IDA] [PMID 20395473]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 12052880]; GO_component: GO:0000124 - SAGA complex [Evidence IPI] [PMID 15932941]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 17090597]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IPI] [PMID 15932941]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 18488019]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 20434206]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 15932941]; GO_function: GO:0005198 - structural molecule activity [Evidence IGI,IMP] [PMID 15932941]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 15932941]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 17090597]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 12052880]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 15932941]; GO_process: GO:0016578 - histone deubiquitination [Evidence IMP] [PMID 19226466]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 18488019]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 17090597]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 19226466]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2867	Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator; GO_component: GO:0030014 - CCR4-NOT complex [Evidence IDA] [PMID 11113136]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 10581358]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP,IPI] [PMID 11113136]
AWJ20_2868	C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 21737688]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000248 - C-5 sterol desaturase activity [Evidence IDA] [PMID 34600]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 1864507]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
AWJ20_2870	Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 10688918]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IBA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence TAS] [PMID 8982460]; GO_process: GO:0010994 - free ubiquitin chain polymerization [Evidence IMP] [PMID 22497224]; GO_process: GO:0006513 - protein monoubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0000209 - protein polyubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]
AWJ20_2871	Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 10688918]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IBA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence TAS] [PMID 8982460]; GO_process: GO:0010994 - free ubiquitin chain polymerization [Evidence IMP] [PMID 22497224]; GO_process: GO:0006513 - protein monoubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0000209 - protein polyubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]
AWJ20_2872	Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein; GO_component: GO:0051285 - cell cortex of cell tip [Evidence IDA] [PMID 23673619]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IGI,IPI] [PMID 8524314]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 8524314]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IGI,IPI] [PMID 8524314]
AWJ20_2873	Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16204239]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0032217 - riboflavin transporter activity [Evidence IGI] [PMID 16204239]; GO_process: GO:0032218 - riboflavin transport [Evidence IGI] [PMID 16204239]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2877	Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 17176761]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19254924]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15950597]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9802016]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015491 - cation:cation antiporter activity [Evidence ISS] [PMID 8654575]; GO_function: GO:0015491 - cation:cation antiporter activity [Evidence IMP] [PMID 9802016]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IEA]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IDA] [PMID 15950597]; GO_function: GO:0015299 - solute:proton antiporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0030004 - cellular monovalent inorganic cation homeostasis [Evidence IMP] [PMID 9802016]; GO_process: GO:0030007 - cellular potassium ion homeostasis [Evidence IMP] [PMID 16402204]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 16402204]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA,IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2878	Nucleolar protein; specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2880	Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 10377407]; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 15485833]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10377407]; GO_process: GO:0045010 - actin nucleation [Evidence IDA] [PMID 15485833]; GO_process: GO:0030833 - regulation of actin filament polymerization [Evidence IEA]
AWJ20_2881	Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0070626 - (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate AMP-lyase (fumarate-forming) activity [Evidence IEA]; GO_function: GO:0004018 - N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [Evidence IEA,IEA]; GO_function: GO:0004018 - N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [Evidence IMP] [PMID 5807803]; GO_function: GO:0004018 - N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [Evidence IMP] [PMID 7896125]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0044208 - 'de novo' AMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 5807803]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IGI] [PMID 7896125]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 5807803]; GO_process: GO:0009152 - purine ribonucleotide biosynthetic process [Evidence IEA]
AWJ20_2882	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16452140]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2884	Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IEA]; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 10377407]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA,IMP] [PMID 15657399]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0034314 - Arp2/3 complex-mediated actin nucleation [Evidence IEA]; GO_process: GO:0034314 - Arp2/3 complex-mediated actin nucleation [Evidence IMP] [PMID 16862144]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10377407]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 11248049]; GO_process: GO:0030833 - regulation of actin filament polymerization [Evidence IEA]
AWJ20_2885	Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2886	Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 18487605]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0097038 - perinuclear endoplasmic reticulum [Evidence IDA] [PMID 18487605]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008117 - sphinganine-1-phosphate aldolase activity [Evidence IEA]; GO_function: GO:0008117 - sphinganine-1-phosphate aldolase activity [Evidence IDA] [PMID 9334171]; GO_process: GO:0019722 - calcium-mediated signaling [Evidence IMP] [PMID 11278643]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 10329480]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IGI,IMP] [PMID 9334171]
AWJ20_2888	hypothetical protein; potential Cdc28p substrate; overproduction confers resistance to methylmercury; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0071406 - cellular response to methylmercury [Evidence IGI,IMP] [PMID 15796894]
AWJ20_2889	Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 10341420]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016722 - oxidoreductase activity, oxidizing metal ions [Evidence ISS] [PMID 10341420]; GO_function: GO:0016722 - oxidoreductase activity, oxidizing metal ions [Evidence IMP] [PMID 14534306]; GO_process: GO:0006875 - cellular metal ion homeostasis [Evidence IMP] [PMID 14534306]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_2890	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0050483 - IMP 5'-nucleotidase activity [Evidence IDA] [PMID 12735798]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006190 - inosine salvage [Evidence IMP] [PMID 12735798]; GO_process: GO:0071590 - nicotinamide riboside biosynthetic process [Evidence IGI,IMP] [PMID 19846558]; GO_process: GO:0071592 - nicotinic acid riboside biosynthetic process [Evidence IGI,IMP] [PMID 19846558]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA,IEA]
AWJ20_2891	Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI,IMP] [PMID 16219777]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IGI] [PMID 14764870]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA,IEA]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 19730685]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IMP] [PMID 18321795]; GO_process: GO:0045132 - meiotic chromosome segregation [Evidence IMP] [PMID 11470404]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 17483413]; GO_process: GO:0008156 - negative regulation of DNA replication [Evidence IEA]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16103218]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16418273]; GO_process: GO:0048478 - replication fork protection [Evidence IEA]; GO_process: GO:0048478 - replication fork protection [Evidence IMP] [PMID 16418273]
AWJ20_2892	Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_function: GO:0052689 - carboxylic ester hydrolase activity [Evidence IEA]; GO_function: GO:0052689 - carboxylic ester hydrolase activity [Evidence IMP] [PMID 11060018]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0006464 - cellular protein modification process [Evidence IGI] [PMID 11060018]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006482 - protein demethylation [Evidence IEA]
AWJ20_2893	Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12898714]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12898714]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003952 - NAD+ synthase (glutamine-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0003952 - NAD+ synthase (glutamine-hydrolyzing) activity [Evidence ISS] [PMID 11380987]; GO_function: GO:0003952 - NAD+ synthase (glutamine-hydrolyzing) activity [Evidence IDA,IMP] [PMID 12771147]; GO_function: GO:0003952 - NAD+ synthase (glutamine-hydrolyzing) activity [Evidence IDA,IMP] [PMID 12898714]; GO_function: GO:0004359 - glutaminase activity [Evidence IDA,IMP] [PMID 12771147]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IDA,IMP] [PMID 12771147]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IDA,IMP] [PMID 12898714]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
AWJ20_2894	Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004349 - glutamate 5-kinase activity [Evidence IEA,IEA]; GO_function: GO:0004349 - glutamate 5-kinase activity [Evidence IDA] [PMID 12513997]; GO_function: GO:0004349 - glutamate 5-kinase activity [Evidence ISS] [PMID 1350780]; GO_function: GO:0004349 - glutamate 5-kinase activity [Evidence IGI,IMP] [PMID 2824433]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0055129 - L-proline biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IDA] [PMID 12513997]
AWJ20_2895	Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18664566]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 14551258]; GO_process: GO:0032447 - protein urmylation [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 14551258]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0034227 - tRNA thio-modification [Evidence IEA,IEA]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 17018299]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 18664566]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 18755837]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19145231]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19151091]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IEA,IEA]
AWJ20_2896	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II; GO_component: GO:0097255 - R2TP complex [Evidence IDA] [PMID 15766533]; GO_component: GO:0097255 - R2TP complex [Evidence IPI] [PMID 18268103]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005732 - small nucleolar ribonucleoprotein complex [Evidence IPI] [PMID 15670595]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 18268103]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IGI,IMP,IPI] [PMID 15766533]; GO_process: GO:0006364 - rRNA processing [Evidence IGI,IMP,IPI] [PMID 15670595]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]
AWJ20_2898	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally propionylated in vivo; protein abundance increases in response to DNA replication stress; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000118 - histone deacetylase complex [Evidence IPI] [PMID 15643056]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643056]; GO_function: GO:0016018 - cyclosporin A binding [Evidence IMP] [PMID 7515500]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0042277 - peptide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 2687115]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 15643056]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IMP] [PMID 11641409]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IMP] [PMID 12242280]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045836 - positive regulation of meiosis [Evidence IGI,IMP] [PMID 15643056]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2901	Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 9774331]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 10777592]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IMP] [PMID 10777592]; GO_function: GO:0030060 - L-malate dehydrogenase activity [Evidence IDA] [PMID 1898005]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016615 - malate dehydrogenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 3312168]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 18381895]; GO_process: GO:0006108 - malate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 18381895]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IMP] [PMID 3312168]
AWJ20_2905	Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0012510 - trans-Golgi network transport vesicle membrane [Evidence IDA] [PMID 9325307]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IDA] [PMID 15078884]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IMP] [PMID 7708696]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IDA] [PMID 17961510]; GO_function: GO:0043682 - copper-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 7708696]; GO_process: GO:0060003 - copper ion export [Evidence IMP] [PMID 7708696]; GO_process: GO:0006825 - copper ion transport [Evidence IEA,IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 7708696]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2906	Phosphorylated and palmitoylated vacuolar membrane protein; interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions; GO_component: GO:0071563 - Myo2p-Vac17p-Vac8p transport complex [Evidence IDA,IPI] [PMID 12529432]; GO_component: GO:0071563 - Myo2p-Vac17p-Vac8p transport complex [Evidence IPI] [PMID 12594460]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 16301533]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9490720]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9664035]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9739084]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0071561 - nucleus-vacuole junction [Evidence IDA,IPI] [PMID 10888680]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0043495 - protein anchor [Evidence IMP,IPI] [PMID 10888680]; GO_function: GO:0043495 - protein anchor [Evidence IMP,IPI] [PMID 12594460]; GO_process: GO:0071255 - CVT vesicle assembly [Evidence IMP] [PMID 10837477]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 15901835]; GO_process: GO:0071562 - nucleus-vacuole junction assembly [Evidence IMP] [PMID 10888680]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 12529432]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 11441010]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 16301533]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 16301533]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 8885233]
AWJ20_2907	Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23706738]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 15020463]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23706738]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 24492965]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IMP] [PMID 17984320]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IGI,IMP] [PMID 18981231]; GO_process: GO:0031087 - deadenylation-independent decapping of nuclear-transcribed mRNA [Evidence IMP] [PMID 15225544]; GO_process: GO:1900153 - positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IMP] [PMID 24492965]
AWJ20_2910	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_2913	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 7589446]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016624 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Evidence IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IEA,IEA]; GO_function: GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity [Evidence IMP] [PMID 11589696]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]
AWJ20_2914	Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16467296]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 16467296]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IDA] [PMID 20876142]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IDA] [PMID 22121197]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IEA]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IDA,IMP] [PMID 16467296]; GO_function: GO:0044212 - transcription regulatory region DNA binding [Evidence IDA] [PMID 15889145]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8437575]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0034389 - lipid particle organization [Evidence IMP] [PMID 21422231]; GO_process: GO:0034389 - lipid particle organization [Evidence IGI] [PMID 21829381]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 16467296]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 17971454]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 8437575]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0019432 - triglyceride biosynthetic process [Evidence IGI,IMP] [PMID 24196957]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 22121197]
AWJ20_2916	U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 8196608]; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0000243 - commitment complex [Evidence IGI] [PMID 8196608]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0030627 - pre-mRNA 5'-splice site binding [Evidence IGI] [PMID 8196608]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000395 - mRNA 5'-splice site recognition [Evidence IGI] [PMID 8196608]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_2917	Putative kinase; suppressor of GTPase mutant, similar to bovine rhodopsin kinase; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]
AWJ20_2918	Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
AWJ20_2919	Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IDA] [PMID 16096264]; GO_function: GO:0015197 - peptide transporter activity [Evidence IMP] [PMID 8264579]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0042937 - tripeptide transporter activity [Evidence IDA] [PMID 16096264]; GO_process: GO:0042938 - dipeptide transport [Evidence IDA] [PMID 16096264]; GO_process: GO:0006857 - oligopeptide transport [Evidence IEA]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015833 - peptide transport [Evidence IMP] [PMID 8264579]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IDA] [PMID 16096264]
AWJ20_2921	Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16871394]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IPI] [PMID 11309412]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16871394]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16871394]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16871394]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 11309412]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2922	Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IDA] [PMID 19753119]; GO_function: GO:0016791 - phosphatase activity [Evidence IDA] [PMID 20427268]; GO_process: GO:0016311 - dephosphorylation [Evidence IDA] [PMID 19753119]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2923	Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000111 - nucleotide-excision repair factor 2 complex [Evidence IDA] [PMID 7768886]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 15117949]; GO_component: GO:0000502 - proteasome complex [Evidence IMP] [PMID 15242647]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9813069]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9837874]; GO_function: GO:0000224 - peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [Evidence IDA] [PMID 20016784]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 15121879]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 11323716]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15167887]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 19889839]; GO_process: GO:0006517 - protein deglycosylation [Evidence IDA] [PMID 20016784]
AWJ20_2925	Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006606 - protein import into nucleus [Evidence IGI] [PMID 23118189]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2926	Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15899842]; GO_component: GO:0043528 - tRNA (m2G10) methyltransferase complex [Evidence IPI] [PMID 15899842]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 15899842]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 12872006]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 15899842]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0004809 - tRNA (guanine-N2-)-methyltransferase activity [Evidence IDA,IMP] [PMID 15899842]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 15899842]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_2927	Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9334319]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15572678]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9334319]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9334319]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15703440]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 17684230]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 9334319]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]
AWJ20_2928	Vacuolar membrane zinc transporter; transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 10856230]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IMP] [PMID 10856230]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 10856230]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IMP] [PMID 10856230]
AWJ20_2929	Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8643535]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IDA] [PMID 10574989]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0015295 - solute:proton symporter activity [Evidence IDA] [PMID 10574989]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015691 - cadmium ion transport [Evidence IGI] [PMID 9115231]; GO_process: GO:0006876 - cellular cadmium ion homeostasis [Evidence IGI] [PMID 9115231]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IGI] [PMID 9115231]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IMP] [PMID 8643535]; GO_process: GO:0006825 - copper ion transport [Evidence IGI] [PMID 9115231]; GO_process: GO:0006826 - iron ion transport [Evidence IGI] [PMID 10930410]; GO_process: GO:0006828 - manganese ion transport [Evidence IMP] [PMID 8643535]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2930	Nucleosome assembly factor; involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11404324]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0042393 - histone binding [Evidence IMP] [PMID 15840725]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IDA] [PMID 11412995]; GO_process: GO:0006336 - DNA replication-independent nucleosome assembly [Evidence IDA] [PMID 16303565]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 15840725]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 15840725]; GO_process: GO:0033523 - histone H2B ubiquitination [Evidence IMP] [PMID 24824343]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 16627621]; GO_process: GO:0043486 - histone exchange [Evidence IMP] [PMID 17679090]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IMP] [PMID 16678113]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IDA,IMP] [PMID 17272722]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IMP] [PMID 17679090]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IMP,IPI] [PMID 17690098]; GO_process: GO:0035066 - positive regulation of histone acetylation [Evidence IDA,IGI,IMP] [PMID 18458063]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 22308335]; GO_process: GO:0043618 - regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP] [PMID 19620280]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_2931	Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_2932	Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 10848624]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21954159]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 9693364]; GO_function: GO:0070290 - N-acylphosphatidylethanolamine-specific phospholipase D activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0004630 - phospholipase D activity [Evidence IEA]; GO_function: GO:0004630 - phospholipase D activity [Evidence IDA] [PMID 11514437]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IMP] [PMID 16554438]; GO_process: GO:0000753 - cell morphogenesis involved in conjugation with cellular fusion [Evidence IMP] [PMID 12702348]; GO_process: GO:0000753 - cell morphogenesis involved in conjugation with cellular fusion [Evidence IGI] [PMID 18036176]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 10848624]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 11514437]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IDA,IMP] [PMID 8576189]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2933	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; PPZ1 has a paralog, PPZ2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 16166647]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8824289]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004724 - magnesium-dependent protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 7615085]; GO_process: GO:0034613 - cellular protein localization [Evidence IMP] [PMID 21237705]; GO_process: GO:0006883 - cellular sodium ion homeostasis [Evidence IGI,IMP] [PMID 7768897]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 21237705]
AWJ20_2934	DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8901577]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 12019222]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 15494305]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9554851]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA,IMP] [PMID 23382391]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 2044962]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16980387]
AWJ20_2936	Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8164662]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 8164662]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 7814363]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IDA] [PMID 8164662]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2937	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_2938	Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 22553209]; GO_function: GO:0005525 - GTP binding [Evidence IDA,IMP] [PMID 22553209]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 22553209]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IMP] [PMID 22553209]
AWJ20_2939	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0003994 - aconitate hydratase activity [Evidence IEA]; GO_function: GO:0003994 - aconitate hydratase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
AWJ20_2941	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_2944	Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 24868093]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 18034159]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 18034159]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0034084 - steryl deacetylase activity [Evidence IDA,IMP] [PMID 18034159]; GO_process: GO:0009636 - response to toxic substance [Evidence IMP] [PMID 18034159]; GO_process: GO:0034210 - sterol deacetylation [Evidence IMP] [PMID 18034159]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 18034159]
AWJ20_2946	similar to S.kluyveri pyd3 (AAK60518) beta-alanine synthase involved in pyrimidine catabolism; allele of CaO19.8949
AWJ20_2947	Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11943786]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA,IGI,IMP,IPI,ISS] [PMID 11943786]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0043619 - regulation of transcription from RNA polymerase II promoter in response to oxidative stress [Evidence IMP] [PMID 16914749]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0009410 - response to xenobiotic stimulus [Evidence IMP] [PMID 11943786]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IDA] [PMID 11943786]
AWJ20_2951	Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9242486]; GO_process: GO:0000161 - MAPK cascade involved in osmosensory signaling pathway [Evidence IMP,IPI] [PMID 17220467]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 17242065]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 7753858]; GO_process: GO:0032872 - regulation of stress-activated MAPK cascade [Evidence IMP,IPI] [PMID 17220467]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IGI,IMP] [PMID 9060463]
AWJ20_2952	Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 10874035]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 10874035]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004820 - glycine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004820 - glycine-tRNA ligase activity [Evidence IMP,ISS] [PMID 10874035]; GO_function: GO:0004820 - glycine-tRNA ligase activity [Evidence IDA] [PMID 21877692]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IMP] [PMID 10224248]; GO_process: GO:0006426 - glycyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006426 - glycyl-tRNA aminoacylation [Evidence IMP,ISS] [PMID 10874035]; GO_process: GO:0070150 - mitochondrial glycyl-tRNA aminoacylation [Evidence IMP] [PMID 10874035]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2953	U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IGI,ISS] [PMID 8449403]; GO_function: GO:0030619 - U1 snRNA binding [Evidence IPI] [PMID 8849781]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0017069 - snRNA binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI] [PMID 8449403]
AWJ20_2955	One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 12475929]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IGI] [PMID 12475929]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IDA] [PMID 12799450]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]; GO_process: GO:0032435 - negative regulation of proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA,IMP] [PMID 17082762]
AWJ20_2957	C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0000249 - C-22 sterol desaturase activity [Evidence IDA] [PMID 8543054]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8543054]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 8635732]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
AWJ20_2958	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000137 - Golgi cis cisterna [Evidence IDA] [PMID 9430634]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 9434768]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA,IMP] [PMID 9430634]
AWJ20_2959	Assembly chaperone for the 19S proteasome regulatory particle base; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19446323]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI] [PMID 19412159]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI] [PMID 19446322]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446323]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17499717]
AWJ20_2960	Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 18048916]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0033180 - proton-transporting V-type ATPase, V1 domain [Evidence IEA]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence IDA] [PMID 2478556]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence IDA] [PMID 2857169]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IMP] [PMID 2141385]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0046034 - ATP metabolic process [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 10991947]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:1902906 - proteasome storage granule assembly [Evidence IMP] [PMID 23690178]; GO_process: GO:0015992 - proton transport [Evidence IEA,IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 2141385]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 18048916]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 2141385]
AWJ20_2962	Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IGI] [PMID 10753927]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 10753927]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0015809 - arginine transport [Evidence IGI,IMP] [PMID 10753927]; GO_process: GO:0015819 - lysine transport [Evidence IMP] [PMID 10753927]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IMP] [PMID 17101785]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_2963	Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11746603]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12606555]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008775 - acetate CoA-transferase activity [Evidence IDA] [PMID 19298859]; GO_function: GO:0003986 - acetyl-CoA hydrolase activity [Evidence IEA]; GO_function: GO:0003986 - acetyl-CoA hydrolase activity [Evidence IDA] [PMID 12606555]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0006083 - acetate metabolic process [Evidence IMP] [PMID 8841387]; GO_process: GO:0006084 - acetyl-CoA metabolic process [Evidence IEA]
AWJ20_2965	Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004849 - uridine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004849 - uridine kinase activity [Evidence IMP] [PMID 10501935]; GO_process: GO:0044211 - CTP salvage [Evidence IEA]; GO_process: GO:0044206 - UMP salvage [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0008655 - pyrimidine-containing compound salvage [Evidence IGI,IMP] [PMID 11872485]
AWJ20_2967	Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 17804816]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015169 - glycerol-3-phosphate transmembrane transporter activity [Evidence IGI,IMP] [PMID 20133652]; GO_function: GO:0005315 - inorganic phosphate transmembrane transporter activity [Evidence IGI] [PMID 11779791]; GO_function: GO:0005315 - inorganic phosphate transmembrane transporter activity [Evidence IMP] [PMID 12581367]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015794 - glycerol-3-phosphate transport [Evidence IGI,IMP] [PMID 20133652]; GO_process: GO:0006817 - phosphate ion transport [Evidence IEA]; GO_process: GO:0006817 - phosphate ion transport [Evidence IGI] [PMID 11779791]; GO_process: GO:0006797 - polyphosphate metabolic process [Evidence IMP] [PMID 17804816]; GO_process: GO:2000185 - regulation of phosphate transmembrane transport [Evidence IGI] [PMID 12821119]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_2970	Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication; GO_component: GO:0005946 - alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [Evidence IGI,IMP,IPI] [PMID 9837904]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0003825 - alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [Evidence IMP,ISS] [PMID 9837904]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP,ISS] [PMID 9837904]; GO_function: GO:0004805 - trehalose-phosphatase activity [Evidence IGI] [PMID 9837904]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IGI,IMP,IPI] [PMID 9837904]
AWJ20_2972	Translation initiation factor eIF1A; essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IDA] [PMID 16380131]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003725 - double-stranded RNA binding [Evidence IDA] [PMID 17673174]; GO_function: GO:0043024 - ribosomal small subunit binding [Evidence IDA] [PMID 17434125]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 12008673]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 10982835]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IMP] [PMID 16461768]; GO_process: GO:0001732 - formation of translation initiation complex [Evidence IGI] [PMID 17242201]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IMP] [PMID 12514125]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 15664195]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IMP] [PMID 15838098]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 17434125]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
AWJ20_2973	Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p; GO_component: GO:0033557 - Slx1-Slx4 complex [Evidence IEA,IEA]; GO_component: GO:0033557 - Slx1-Slx4 complex [Evidence IPI] [PMID 12832395]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 12832395]; GO_function: GO:0017108 - 5'-flap endonuclease activity [Evidence IEA,IEA]; GO_function: GO:0017108 - 5'-flap endonuclease activity [Evidence IDA] [PMID 12832395]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IGI] [PMID 12832395]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_2975	Glucosidase II catalytic subunit; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence ISS] [PMID 8910335]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 16373354]; GO_component: GO:0017177 - glucosidase II complex [Evidence IPI] [PMID 16373354]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0033919 - glucan 1,3-alpha-glucosidase activity [Evidence IEA]; GO_function: GO:0033919 - glucan 1,3-alpha-glucosidase activity [Evidence IMP] [PMID 16373354]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IMP] [PMID 9430631]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_2976	Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IC] [PMID 9643541]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 19767828]
AWJ20_2977	3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine; localized to lipid droplets; member of short chain dehydrogenase/reductase protein family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0047560 - 3-dehydrosphinganine reductase activity [Evidence IEA]; GO_function: GO:0047560 - 3-dehydrosphinganine reductase activity [Evidence IDA] [PMID 9804843]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006666 - 3-keto-sphinganine metabolic process [Evidence IDA] [PMID 9804843]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IDA,IMP,ISS] [PMID 9804843]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA,IEA]
AWJ20_2978	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 2183197]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_2979	Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_2981	Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p; GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 16580990]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 15642746]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005868 - cytoplasmic dynein complex [Evidence IPI] [PMID 9658168]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 12566428]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 15965467]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0030286 - dynein complex [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 16580990]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IDA] [PMID 16873064]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0040001 - establishment of mitotic spindle localization [Evidence IMP] [PMID 21633107]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IGI,IMP] [PMID 9201714]
AWJ20_2982	Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p; GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 16580990]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 15642746]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005868 - cytoplasmic dynein complex [Evidence IPI] [PMID 9658168]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 12566428]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 15965467]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0030286 - dynein complex [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 16580990]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IDA] [PMID 16873064]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0040001 - establishment of mitotic spindle localization [Evidence IMP] [PMID 21633107]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IGI,IMP] [PMID 9201714]
AWJ20_2983	Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p; GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 16580990]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 15642746]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005868 - cytoplasmic dynein complex [Evidence IPI] [PMID 9658168]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 12566428]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 15965467]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0030286 - dynein complex [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 16580990]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IDA] [PMID 16873064]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0040001 - establishment of mitotic spindle localization [Evidence IMP] [PMID 21633107]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IGI,IMP] [PMID 9201714]
AWJ20_2984	Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p; GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 16580990]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 15642746]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005868 - cytoplasmic dynein complex [Evidence IPI] [PMID 9658168]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 12566428]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 15965467]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0030286 - dynein complex [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 16580990]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IDA] [PMID 16873064]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0040001 - establishment of mitotic spindle localization [Evidence IMP] [PMID 21633107]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IGI,IMP] [PMID 9201714]
AWJ20_2985	Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p; GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 16580990]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 15642746]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005868 - cytoplasmic dynein complex [Evidence IPI] [PMID 9658168]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 12566428]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 15965467]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0030286 - dynein complex [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 16580990]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IDA] [PMID 16873064]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0040001 - establishment of mitotic spindle localization [Evidence IMP] [PMID 21633107]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0000741 - karyogamy [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IGI,IMP] [PMID 9201714]
AWJ20_2987	F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 11283612]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IMP,IPI,ISS] [PMID 17517885]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 19882662]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP,ISS] [PMID 17517885]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16677311]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP,ISS] [PMID 17517885]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
AWJ20_2988	Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11595741]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11595741]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17717527]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11595741]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 15583030]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 15583030]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 15583030]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
AWJ20_2991	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0008474 - palmitoyl-(protein) hydrolase activity [Evidence IDA,IMP,ISS] [PMID 12080046]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0035601 - protein deacylation [Evidence IDA,IMP] [PMID 12080046]
AWJ20_2992	Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p, Sen15p, Sen34p, and Sen54p; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA,IMP] [PMID 12925762]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000214 - tRNA-intron endonuclease complex [Evidence IDA] [PMID 9200603]; GO_function: GO:0000213 - tRNA-intron endonuclease activity [Evidence IDA] [PMID 9200603]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0000379 - tRNA-type intron splice site recognition and cleavage [Evidence IDA] [PMID 9200603]
AWJ20_2993	Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12668726]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12668726]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15935782]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 17446860]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IGI,IMP] [PMID 23444383]; GO_process: GO:0016579 - protein deubiquitination [Evidence IGI,IPI] [PMID 15326198]; GO_process: GO:0043328 - protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 14523026]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007584 - response to nutrient [Evidence IMP] [PMID 8649366]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12062418]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP] [PMID 12668726]
AWJ20_2994	Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 12686616]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12686616]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 18508925]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_2995	Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IPI] [PMID 16675952]; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IMP] [PMID 17296727]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0070449 - elongin complex [Evidence IPI] [PMID 10430890]; GO_component: GO:0070449 - elongin complex [Evidence IPI] [PMID 10753924]; GO_component: GO:0000113 - nucleotide-excision repair factor 4 complex [Evidence IDA] [PMID 15226437]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16675952]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 18817898]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 16675952]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16705154]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_2997	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000942 - condensed nuclear chromosome outer kinetochore [Evidence IDA] [PMID 12589047]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 12589047]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP] [PMID 12642611]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0034508 - centromere complex assembly [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8243998]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 9339342]; GO_process: GO:0034089 - establishment of meiotic sister chromatid cohesion [Evidence IMP] [PMID 19730685]; GO_process: GO:0034087 - establishment of mitotic sister chromatid cohesion [Evidence IMP] [PMID 19730685]; GO_process: GO:0051382 - kinetochore assembly [Evidence IMP] [PMID 12642611]; GO_process: GO:0034090 - maintenance of meiotic sister chromatid cohesion [Evidence IMP] [PMID 14752166]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0071459 - protein localization to chromosome, centromeric region [Evidence IMP] [PMID 16357219]; GO_process: GO:0071173 - spindle assembly checkpoint [Evidence IMP] [PMID 22426531]
AWJ20_2998	Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9312154]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8039505]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 8039505]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_2999	tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016300 - tRNA (uracil) methyltransferase activity [Evidence IDA,IMP] [PMID 18025252]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 18025252]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_3000	Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 16611745]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 7973730]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 7973731]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 8108735]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 9584169]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9853758]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 12407105]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 19823668]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 7973730]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 7973731]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 8108735]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 9584169]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI,IMP] [PMID 16964260]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 12077337]; GO_process: GO:0050849 - negative regulation of calcium-mediated signaling [Evidence IGI] [PMID 16455487]; GO_process: GO:0045719 - negative regulation of glycogen biosynthetic process [Evidence IMP] [PMID 9584169]; GO_process: GO:0016242 - negative regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0045936 - negative regulation of phosphate metabolic process [Evidence IGI] [PMID 3915785]; GO_process: GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity [Evidence IGI] [PMID 12101234]; GO_process: GO:0043433 - negative regulation of sequence-specific DNA binding transcription factor activity [Evidence IMP] [PMID 16455487]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 3915785]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 19823668]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 7973731]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8108735]; GO_process: GO:0032878 - regulation of establishment or maintenance of cell polarity [Evidence IGI] [PMID 17853895]; GO_process: GO:0032880 - regulation of protein localization [Evidence IDA] [PMID 8539622]; GO_process: GO:0031647 - regulation of protein stability [Evidence IMP] [PMID 16508019]; GO_process: GO:0031647 - regulation of protein stability [Evidence IGI] [PMID 16611745]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 15738404]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 19823668]
AWJ20_3001	Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11595741]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9491896]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11595741]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17717527]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9491896]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11595741]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9491896]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9491896]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IDA] [PMID 11283608]; GO_function: GO:0017049 - GTP-Rho binding [Evidence IPI] [PMID 11595741]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 18195105]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 12960429]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IGI,IMP] [PMID 15583030]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 15583030]; GO_process: GO:0051601 - exocyst localization [Evidence IGI] [PMID 17717527]; GO_process: GO:0051601 - exocyst localization [Evidence IGI] [PMID 18946089]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 12913108]; GO_process: GO:0006887 - exocytosis [Evidence IDA] [PMID 15772160]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17717527]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
AWJ20_3002	Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15888545]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA,IPI] [PMID 7935466]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IEA]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA,IPI] [PMID 15888545]; GO_function: GO:0001129 - TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [Evidence IDA,IMP] [PMID 10464320]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IDA,IMP] [PMID 10464320]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA,IMP] [PMID 10464320]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 9887099]; GO_process: GO:2000679 - positive regulation of transcription regulatory region DNA binding [Evidence IDA] [PMID 8132551]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001113 - transcriptional open complex formation at RNA polymerase II promoter [Evidence IMP] [PMID 19820686]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IMP] [PMID 19820686]
AWJ20_3003	GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16803892]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IGI] [PMID 16803892]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 16803892]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 16803892]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12089522]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 11583615]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3004	Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8810273]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008559 - xenobiotic-transporting ATPase activity [Evidence IDA] [PMID 21207971]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015893 - drug transport [Evidence TAS] [PMID 11421285]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046677 - response to antibiotic [Evidence IEA]; GO_process: GO:0046898 - response to cycloheximide [Evidence IEA]; GO_process: GO:0042493 - response to drug [Evidence TAS] [PMID 11421285]; GO_process: GO:0042493 - response to drug [Evidence IMP] [PMID 17881724]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3005	Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IDA] [PMID 8127709]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8127709]
AWJ20_3011	TATA-binding protein; general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 8702872]; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 9632758]; GO_component: GO:0000500 - RNA polymerase I upstream activating factor complex [Evidence IDA] [PMID 9632758]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9818719]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_component: GO:0000126 - transcription factor TFIIIB complex [Evidence IDA] [PMID 1423590]; GO_component: GO:0000126 - transcription factor TFIIIB complex [Evidence IDA] [PMID 1458536]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 1736286]; GO_function: GO:0001179 - RNA polymerase I transcription factor binding [Evidence IDA,IPI] [PMID 8895657]; GO_function: GO:0001186 - RNA polymerase I transcription factor recruiting transcription factor activity [Evidence IDA,IPI] [PMID 8895657]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA,IPI] [PMID 12501245]; GO_function: GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding [Evidence IDA] [PMID 2677740]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0001016 - RNA polymerase III regulatory region DNA binding [Evidence IDA] [PMID 8662956]; GO_function: GO:0001026 - TFIIIB-type transcription factor activity [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 19098311]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0070898 - RNA polymerase III transcriptional preinitiation complex assembly [Evidence IDA] [PMID 1480467]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IMP] [PMID 1586947]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0070893 - transposon integration [Evidence IDA] [PMID 10882723]
AWJ20_3012	TATA-binding protein; general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 8702872]; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 9632758]; GO_component: GO:0000500 - RNA polymerase I upstream activating factor complex [Evidence IDA] [PMID 9632758]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9818719]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_component: GO:0000126 - transcription factor TFIIIB complex [Evidence IDA] [PMID 1423590]; GO_component: GO:0000126 - transcription factor TFIIIB complex [Evidence IDA] [PMID 1458536]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 1736286]; GO_function: GO:0001179 - RNA polymerase I transcription factor binding [Evidence IDA,IPI] [PMID 8895657]; GO_function: GO:0001186 - RNA polymerase I transcription factor recruiting transcription factor activity [Evidence IDA,IPI] [PMID 8895657]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA,IPI] [PMID 12501245]; GO_function: GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding [Evidence IDA] [PMID 2677740]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0001016 - RNA polymerase III regulatory region DNA binding [Evidence IDA] [PMID 8662956]; GO_function: GO:0001026 - TFIIIB-type transcription factor activity [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 19098311]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0070898 - RNA polymerase III transcriptional preinitiation complex assembly [Evidence IDA] [PMID 1480467]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IMP] [PMID 1586947]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0070893 - transposon integration [Evidence IDA] [PMID 10882723]
AWJ20_3015	Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 3550419]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 3550419]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 3546317]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006113 - fermentation [Evidence ISS] [PMID 3550419]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3018	Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence NAS] [PMID 3928261]; GO_function: GO:0004043 - L-aminoadipate-semialdehyde dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004043 - L-aminoadipate-semialdehyde dehydrogenase activity [Evidence IDA] [PMID 10320345]; GO_function: GO:0004043 - L-aminoadipate-semialdehyde dehydrogenase activity [Evidence IMP] [PMID 3023949]; GO_function: GO:0004043 - L-aminoadipate-semialdehyde dehydrogenase activity [Evidence IMP] [PMID 4401608]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0031177 - phosphopantetheine binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IDA] [PMID 10320345]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 3023949]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IMP] [PMID 4401608]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3019	Subunit of CCR4-NOT global transcriptional regulator; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers; GO_component: GO:0030015 - CCR4-NOT core complex [Evidence IPI] [PMID 10490603]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11889048]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16926149]; GO_process: GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening [Evidence IDA] [PMID 11889048]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA,IPI] [PMID 21406554]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 16926149]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 10490603]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3020	Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 2843500]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004802 - transketolase activity [Evidence IEA,IEA]; GO_function: GO:0004802 - transketolase activity [Evidence IMP,ISS] [PMID 8226984]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IMP] [PMID 8299150]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence TAS] [PMID 8534086]
AWJ20_3023	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 22678361]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 22678362]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3024	Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IDA] [PMID 8135547]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 8226802]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 11551505]; GO_process: GO:0007535 - donor selection [Evidence IGI] [PMID 22496671]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 16607517]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16952051]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IDA] [PMID 11551505]; GO_process: GO:0006359 - regulation of transcription from RNA polymerase III promoter [Evidence IDA] [PMID 11551505]
AWJ20_3025	Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16962805]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 20980819]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 17636314]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IMP] [PMID 21347277]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 11287619]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 11389843]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 17483413]
AWJ20_3026	Type I membrane protein involved in autophagy and the Cvt pathway; may be involved in membrane delivery to the phagophore assembly site; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA,ISS] [PMID 12186856]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17135291]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 17135291]; GO_component: GO:0034045 - pre-autophagosomal structure membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16107716]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 12186856]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 17135291]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 17135291]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 17135291]; GO_process: GO:0034497 - protein localization to pre-autophagosomal structure [Evidence IMP] [PMID 17135291]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IMP] [PMID 12186856]
AWJ20_3028	Assembly factor for the F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for the assembly of alpha and beta subunits into the F1 sector of the mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1826907]; GO_function: GO:0019904 - protein domain specific binding [Evidence IPI] [PMID 10747017]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IPI] [PMID 10747017]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP] [PMID 2142305]; GO_process: GO:0043461 - proton-transporting ATP synthase complex assembly [Evidence IEA]
AWJ20_3030	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005874 - microtubule [Evidence IEA,IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0043234 - protein complex [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_component: GO:0045298 - tubulin complex [Evidence IDA,IPI] [PMID 9488492]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0045143 - homologous chromosome segregation [Evidence IC] [PMID 9488492]; GO_process: GO:0007017 - microtubule-based process [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IC] [PMID 9488492]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IC] [PMID 9488492]; GO_process: GO:0051258 - protein polymerization [Evidence IEA]; GO_process: GO:0046677 - response to antibiotic [Evidence IEA]
AWJ20_3031	Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 196563]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2665820]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004736 - pyruvate carboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004736 - pyruvate carboxylase activity [Evidence IMP] [PMID 2039506]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA,IEA,IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 8185321]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
AWJ20_3032	ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14763985]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005844 - polysome [Evidence TAS] [PMID 10098411]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence TAS] [PMID 10322435]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence TAS] [PMID 10322435]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence TAS] [PMID 10098411]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0043024 - ribosomal small subunit binding [Evidence IDA] [PMID 23801788]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 23390378]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 16157874]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 16777600]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 16285926]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12769863]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA,IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence TAS] [PMID 10098411]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP,IPI] [PMID 18676617]; GO_process: GO:0006449 - regulation of translational termination [Evidence TAS] [PMID 10098411]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 15388879]
AWJ20_3034	Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA; GO_component: GO:0031429 - box H/ACA snoRNP complex [Evidence IEA]; GO_component: GO:0031429 - box H/ACA snoRNP complex [Evidence IPI] [PMID 2898766]; GO_component: GO:0031429 - box H/ACA snoRNP complex [Evidence IPI] [PMID 9843512]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 1531632]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005732 - small nucleolar ribonucleoprotein complex [Evidence IPI] [PMID 1531632]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0034513 - box H/ACA snoRNA binding [Evidence IPI] [PMID 9556561]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IDA] [PMID 15962000]
AWJ20_3038	Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10954428]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11452010]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11452010]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 16563434]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 10954428]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 16582425]
AWJ20_3040	Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; similar to mammalian alpha-SNAP; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8636207]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 1601878]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 10387016]; GO_function: GO:0005483 - soluble NSF attachment protein activity [Evidence IPI] [PMID 10387016]; GO_function: GO:0005483 - soluble NSF attachment protein activity [Evidence IDA] [PMID 11994317]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IDA] [PMID 18650938]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IDA] [PMID 9425154]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 11694599]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 8670830]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA] [PMID 9685264]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IDA] [PMID 1601878]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_3041	Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; GO_component: GO:0005951 - carbamoyl-phosphate synthase complex [Evidence IDA] [PMID 206535]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IMP] [PMID 6358221]; GO_function: GO:0004088 - carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 8626695]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IMP] [PMID 8626695]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
AWJ20_3042	Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; GO_component: GO:0000124 - SAGA complex [Evidence IEA]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9224714]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IEA]; GO_function: GO:0003712 - transcription cofactor activity [Evidence IGI,IMP,IPI] [PMID 8649430]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 10652329]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3044	Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10681558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP,ISS] [PMID 10681558]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 10681558]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0010038 - response to metal ion [Evidence IMP] [PMID 12270680]
AWJ20_3046	Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23706738]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA,IMP] [PMID 12730603]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23509072]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23706738]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 16341225]; GO_function: GO:0050072 - m7G(5')pppN diphosphatase activity [Evidence IDA] [PMID 16341225]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 11139489]; GO_process: GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA [Evidence IDA] [PMID 11139489]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]
AWJ20_3048	Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP] [PMID 9430719]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 9430719]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 9430719]; GO_process: GO:0015693 - magnesium ion transport [Evidence IDA] [PMID 12167543]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 9430719]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3049	Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21273246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21273246]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 21273246]
AWJ20_3054	Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IEA]; GO_function: GO:0005262 - calcium channel activity [Evidence IDA] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IMP] [PMID 9343395]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005245 - voltage-gated calcium channel activity [Evidence ISS] [PMID 9343395]; GO_function: GO:0005244 - voltage-gated ion channel activity [Evidence IEA]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA] [PMID 10958666]; GO_process: GO:0006816 - calcium ion transport [Evidence IMP] [PMID 9343395]; GO_process: GO:0006811 - ion transport [Evidence IEA,IEA]; GO_process: GO:0034765 - regulation of ion transmembrane transport [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3055	Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IEA]; GO_function: GO:0005262 - calcium channel activity [Evidence IDA] [PMID 10958666]; GO_function: GO:0005262 - calcium channel activity [Evidence IMP] [PMID 9343395]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005245 - voltage-gated calcium channel activity [Evidence ISS] [PMID 9343395]; GO_function: GO:0005244 - voltage-gated ion channel activity [Evidence IEA]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA] [PMID 10958666]; GO_process: GO:0006816 - calcium ion transport [Evidence IMP] [PMID 9343395]; GO_process: GO:0006811 - ion transport [Evidence IEA,IEA]; GO_process: GO:0034765 - regulation of ion transmembrane transport [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3057	Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10877846]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003937 - IMP cyclohydrolase activity [Evidence IEA,IEA]; GO_function: GO:0003937 - IMP cyclohydrolase activity [Evidence IDA] [PMID 10877846]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity [Evidence IDA] [PMID 10877846]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IDA,IMP] [PMID 10877846]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IDA,IMP] [PMID 10877846]
AWJ20_3058	Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 6814480]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3061	hypothetical protein; similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17034789]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17034789]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003934 - GTP cyclohydrolase I activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0035998 - 7,8-dihydroneopterin 3'-triphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3062	Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1; GO_component: GO:0070209 - ASTRA complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0000784 - nuclear chromosome, telomeric region [Evidence IDA] [PMID 9490802]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 10525964]; GO_process: GO:0034502 - protein localization to chromosome [Evidence IMP] [PMID 18334620]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 3513174]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 8649421]
AWJ20_3064	O-acetyl homoserine-O-acetyl serine sulfhydrylase; required for Methionine and cysteine biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003961 - O-acetylhomoserine aminocarboxypropyltransferase activity [Evidence IEA]; GO_function: GO:0003961 - O-acetylhomoserine aminocarboxypropyltransferase activity [Evidence TAS] [PMID 3299001]; GO_function: GO:0003961 - O-acetylhomoserine aminocarboxypropyltransferase activity [Evidence IDA] [PMID 7765825]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004124 - cysteine synthase activity [Evidence IEA]; GO_function: GO:0004124 - cysteine synthase activity [Evidence IDA] [PMID 7765825]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0071266 - 'de novo' L-methionine biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence TAS] [PMID 15042590]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006555 - methionine metabolic process [Evidence IMP] [PMID 1101032]
AWJ20_3066	hypothetical protein with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3067	Actin-binding protein of the cortical actin cytoskeleton; important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; inhibits barbed-end actin filament elongation; phosphorylation within its Proline-Rich Regio, mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences; mammalian homologue of HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa); GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 3060468]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 8163554]; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 11950888]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 3060468]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence IMP] [PMID 18177206]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence IMP] [PMID 2405279]; GO_process: GO:0051016 - barbed-end actin filament capping [Evidence IMP] [PMID 23333351]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 11668184]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 15798181]
AWJ20_3069	Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19797078]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 22096102]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 19797079]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0070180 - large ribosomal subunit rRNA binding [Evidence IDA] [PMID 16164560]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 22096102]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 8195220]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 8195220]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA]
AWJ20_3071	hypothetical protein; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3072	Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1 (CLNs), S and G2/M (CLBs) phase cyclins, which provide substrate specificity; regulates cell cycle and basal transcription, chromosome duplication and segregation, lipid biosynthesis, membrane trafficking, polarized growth, and morphogenesis; abundance increases in DNA replication stress; transcript induction in osmostress involves antisense RNA; GO_component: GO:0000235 - astral microtubule [Evidence IDA] [PMID 15256500]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12554645]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IDA] [PMID 1849458]; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IDA] [PMID 2142620]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 3312233]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17560371]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14685274]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12554645]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 22689984]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_function: GO:0004693 - cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 2142620]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 20855529]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 22689984]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 23314252]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 24319056]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IMP] [PMID 22689984]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 20855529]; GO_process: GO:0000706 - meiotic DNA double-strand break processing [Evidence IGI] [PMID 20150422]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:2001033 - negative regulation of double-strand break repair via nonhomologous end joining [Evidence IMP] [PMID 19699692]; GO_process: GO:0051447 - negative regulation of meiotic cell cycle [Evidence IMP] [PMID 12081645]; GO_process: GO:0045930 - negative regulation of mitotic cell cycle [Evidence IDA] [PMID 10074450]; GO_process: GO:0045875 - negative regulation of sister chromatid cohesion [Evidence IMP] [PMID 21549314]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IMP] [PMID 12081645]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IDA,IMP] [PMID 14993267]; GO_process: GO:0018105 - peptidyl-serine phosphorylation [Evidence IDA] [PMID 23314252]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 22689984]; GO_process: GO:0051446 - positive regulation of meiotic cell cycle [Evidence IDA,IMP] [PMID 16814718]; GO_process: GO:0051446 - positive regulation of meiotic cell cycle [Evidence IMP] [PMID 2680756]; GO_process: GO:0045931 - positive regulation of mitotic cell cycle [Evidence IMP] [PMID 2165600]; GO_process: GO:0045931 - positive regulation of mitotic cell cycle [Evidence IMP] [PMID 7002718]; GO_process: GO:0010571 - positive regulation of nuclear cell cycle DNA replication [Evidence IMP] [PMID 12783856]; GO_process: GO:0010571 - positive regulation of nuclear cell cycle DNA replication [Evidence IDA,IMP] [PMID 14747467]; GO_process: GO:0010571 - positive regulation of nuclear cell cycle DNA replication [Evidence IMP] [PMID 4580573]; GO_process: GO:0010696 - positive regulation of spindle pole body separation [Evidence IGI,IMP] [PMID 16688214]; GO_process: GO:0010696 - positive regulation of spindle pole body separation [Evidence IMP] [PMID 8887667]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22689984]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA,IGI] [PMID 1652372]; GO_process: GO:0010898 - positive regulation of triglyceride catabolic process [Evidence IGI,IMP] [PMID 19150427]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0010568 - regulation of budding cell apical bud growth [Evidence IGI,IMP] [PMID 17417630]; GO_process: GO:0010569 - regulation of double-strand break repair via homologous recombination [Evidence IMP] [PMID 15496928]; GO_process: GO:0010570 - regulation of filamentous growth [Evidence IMP] [PMID 9891070]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 19188495]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 20702586]; GO_process: GO:0007130 - synaptonemal complex assembly [Evidence IMP] [PMID 20825495]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 22767578]
AWJ20_3073	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_3074	hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3075	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog, RNR4, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12732713]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9315670]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12732713]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IDA] [PMID 10716984]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10535923]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10716984]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0009186 - deoxyribonucleoside diphosphate metabolic process [Evidence IEA]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 10535923]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 5459124]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3077	Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 16505166]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005771 - multivesicular body [Evidence IDA] [PMID 14701806]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA,IMP] [PMID 16505166]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 16601096]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP,IPI] [PMID 12953057]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 16505166]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0032461 - positive regulation of protein oligomerization [Evidence IDA] [PMID 16505166]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3078	Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0005850 - eukaryotic translation initiation factor 2 complex [Evidence IEA]; GO_component: GO:0005850 - eukaryotic translation initiation factor 2 complex [Evidence IMP,ISS] [PMID 2649894]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 9841679]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence TAS] [PMID 9841679]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence TAS] [PMID 9841679]
AWJ20_3080	hypothetical protein; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22412880]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22412880]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3081	Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex; GO_component: GO:0030122 - AP-2 adaptor complex [Evidence IDA] [PMID 10564262]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0030139 - endocytic vesicle [Evidence IDA] [PMID 22190733]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IC] [PMID 22190733]
AWJ20_3082	3'-5' DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; acts with Rad4p in nucleotide-excision repair; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome (RTS); GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 23026052]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IDA] [PMID 23026052]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 23026052]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IGI,IPI] [PMID 24682993]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_3083	Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14665464]; GO_function: GO:0031435 - mitogen-activated protein kinase kinase kinase binding [Evidence IPI] [PMID 9482735]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IEA]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IMP] [PMID 8183345]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA] [PMID 18573873]; GO_function: GO:0030295 - protein kinase activator activity [Evidence IDA,IMP] [PMID 9482735]; GO_process: GO:0000167 - activation of MAPKKK activity involved in osmosensory signaling pathway [Evidence IMP] [PMID 18573873]; GO_process: GO:0000167 - activation of MAPKKK activity involved in osmosensory signaling pathway [Evidence IGI] [PMID 9482735]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IMP] [PMID 19633059]; GO_process: GO:0031954 - positive regulation of protein autophosphorylation [Evidence IDA] [PMID 9482735]
AWJ20_3084	bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 10710415]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 9832522]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3085	Ubiquitin-conjugating enzyme (E2); key E2 partner with Ubc1p for the anaphase-promoting complex (APC); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication; GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 10848595]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 11788821]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA,IMP] [PMID 21357418]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 2154373]; GO_process: GO:0034605 - cellular response to heat [Evidence IDA] [PMID 2154373]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA] [PMID 8391479]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA] [PMID 2154373]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 16926149]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 11788821]
AWJ20_3086	Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10954428]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11452010]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11452010]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 16563434]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 10954428]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 16582425]
AWJ20_3088	Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p; GO_component: GO:0030127 - COPII vesicle coat [Evidence IEA]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 11086000]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 12426382]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence ISS] [PMID 12941277]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA] [PMID 12426382]; GO_process: GO:0090110 - cargo loading into COPII-coated vesicle [Evidence IDA,IMP] [PMID 12941277]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_3090	Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9499403]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9499403]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 14676199]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0071028 - nuclear mRNA surveillance [Evidence IMP] [PMID 24452287]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IPI] [PMID 14769921]
AWJ20_3091	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation; GO_component: GO:0005671 - Ada2/Gcn5/Ada3 transcription activator complex [Evidence IMP,IPI] [PMID 21734642]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 12052880]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IMP] [PMID 21685874]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 21685874]; GO_process: GO:0034629 - cellular protein complex localization [Evidence IMP] [PMID 21685874]; GO_process: GO:0034613 - cellular protein localization [Evidence IMP] [PMID 22224423]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0070868 - heterochromatin organization involved in chromatin silencing [Evidence IMP] [PMID 24307402]; GO_process: GO:0044154 - histone H3-K14 acetylation [Evidence IMP] [PMID 21685874]; GO_process: GO:0043971 - histone H3-K18 acetylation [Evidence IMP] [PMID 21685874]; GO_process: GO:0043970 - histone H3-K9 acetylation [Evidence IMP] [PMID 21685874]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 21685874]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3092	Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9799363]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0008444 - CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [Evidence IEA]; GO_function: GO:0008444 - CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [Evidence IMP] [PMID 9545322]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016780 - phosphotransferase activity, for other substituted phosphate groups [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032049 - cardiolipin biosynthetic process [Evidence IMP] [PMID 9545322]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006655 - phosphatidylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
AWJ20_3093	Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IDA] [PMID 12392552]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3094	DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0000121 - glycerol-1-phosphatase activity [Evidence IEA]; GO_function: GO:0000121 - glycerol-1-phosphatase activity [Evidence IDA] [PMID 8662716]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IDA] [PMID 8662716]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006114 - glycerol biosynthetic process [Evidence IMP] [PMID 11058591]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IDA] [PMID 8662716]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_3097	3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA in error-free bypass pathway, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; similar to FANCM human Fanconi anemia complementation group protein that with MHF complex is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10880470]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19995966]; GO_function: GO:0043138 - 3'-5' DNA helicase activity [Evidence IDA] [PMID 15634678]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0070336 - flap-structured DNA binding [Evidence IDA] [PMID 19181670]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0033567 - DNA replication, Okazaki fragment processing [Evidence IGI] [PMID 19181670]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0060543 - negative regulation of strand invasion [Evidence IDA,IMP] [PMID 19136626]; GO_process: GO:0000725 - recombinational repair [Evidence IMP] [PMID 19995966]
AWJ20_3098	Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 10551827]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 10409709]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0017110 - nucleoside-diphosphatase activity [Evidence IDA] [PMID 10409709]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IDA] [PMID 10409709]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 10409709]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
AWJ20_3100	Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 8978675]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 7026045]; GO_process: GO:0006887 - exocytosis [Evidence IEA,IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 6996832]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048278 - vesicle docking [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 8978675]
AWJ20_3101	Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 18332110]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12524434]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 7969142]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 11285273]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IGI,IMP] [PMID 9560393]; GO_process: GO:0016311 - dephosphorylation [Evidence IMP] [PMID 18332110]
AWJ20_3106	Component of the exomer complex; exomer also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; Chs5p is the only protein with a BRCT domain that is not localized to the nucleus; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9008706]; GO_component: GO:0034044 - exomer complex [Evidence IDA] [PMID 17000877]; GO_component: GO:0034044 - exomer complex [Evidence IDA] [PMID 23000721]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 11879634]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI,IMP] [PMID 16498409]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 9111317]; GO_process: GO:0006039 - cell wall chitin catabolic process [Evidence IMP] [PMID 9111317]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 16498409]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 9111317]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IDA] [PMID 17000877]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3107	Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence TAS] [PMID 11780757]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0033180 - proton-transporting V-type ATPase, V1 domain [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
AWJ20_3111	Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 2445736]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0004608 - phosphatidylethanolamine N-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004608 - phosphatidylethanolamine N-methyltransferase activity [Evidence IDA,IGI] [PMID 2445736]; GO_function: GO:0004608 - phosphatidylethanolamine N-methyltransferase activity [Evidence IDA,IMP] [PMID 3066687]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IMP] [PMID 23000174]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA,IGI] [PMID 2445736]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA,IMP] [PMID 3066687]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IEA]
AWJ20_3112	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 8534909]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071028 - nuclear mRNA surveillance [Evidence IMP] [PMID 11030620]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 18591258]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18007593]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_3113	Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16924500]; GO_component: GO:0005886 - plasma membrane [Evidence IMP] [PMID 9691030]; GO_function: GO:0015169 - glycerol-3-phosphate transmembrane transporter activity [Evidence IGI,IMP] [PMID 20133652]; GO_function: GO:0001406 - glycerophosphodiester transmembrane transporter activity [Evidence IDA] [PMID 16924500]; GO_function: GO:0001406 - glycerophosphodiester transmembrane transporter activity [Evidence IMP] [PMID 9691030]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015794 - glycerol-3-phosphate transport [Evidence IGI,IMP] [PMID 20133652]; GO_process: GO:0001407 - glycerophosphodiester transport [Evidence IDA] [PMID 16924500]; GO_process: GO:0001407 - glycerophosphodiester transport [Evidence IMP] [PMID 9691030]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 9691030]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3114	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3115	Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock; GO_component: GO:0005622 - intracellular [Evidence TAS] [PMID 12406228]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004363 - glutathione synthase activity [Evidence IEA,IEA]; GO_function: GO:0004363 - glutathione synthase activity [Evidence IDA] [PMID 9512666]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006750 - glutathione biosynthetic process [Evidence IMP] [PMID 9512666]
AWJ20_3116	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0015606 - spermidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IDA,IMP] [PMID 15637075]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 9920864]; GO_process: GO:1902047 - polyamine transmembrane transport [Evidence IMP] [PMID 24136413]; GO_process: GO:0015847 - putrescine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0015848 - spermidine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0015848 - spermidine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IDA,IMP] [PMID 15637075]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 9920864]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3117	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10903515]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015244 - fluconazole transporter activity [Evidence ISS] [PMID 9235926]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI,IMP] [PMID 10572257]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI] [PMID 9235926]; GO_process: GO:0015893 - drug transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9235926]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3118	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10903515]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015244 - fluconazole transporter activity [Evidence ISS] [PMID 9235926]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI,IMP] [PMID 10572257]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI] [PMID 9235926]; GO_process: GO:0015893 - drug transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9235926]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3119	Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 19806183]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11452010]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IMP] [PMID 20498295]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 20498295]
AWJ20_3120	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]
AWJ20_3122	ssDNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1324172]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 1324172]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006264 - mitochondrial DNA replication [Evidence ISS] [PMID 1324172]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 1324172]
AWJ20_3124	Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11069679]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IEA]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IDA,IMP] [PMID 9234685]; GO_process: GO:0072488 - ammonium transmembrane transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEA,IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IMP] [PMID 9234685]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 9234685]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9482721]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3125	One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 7744969]; GO_function: GO:0051087 - chaperone binding [Evidence IMP,ISS] [PMID 9817751]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11381090]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IMP] [PMID 9817751]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006986 - response to unfolded protein [Evidence IMP] [PMID 9817751]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3127	Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 12437924]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 12437925]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030943 - mitochondrion targeting sequence binding [Evidence IDA] [PMID 18418384]; GO_function: GO:0030943 - mitochondrion targeting sequence binding [Evidence IDA] [PMID 19144822]; GO_function: GO:0015266 - protein channel activity [Evidence IMP] [PMID 16763150]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 12437924]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 12437925]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0046902 - regulation of mitochondrial membrane permeability [Evidence IDA] [PMID 16763150]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3128	Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8654588]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3129	Poly(rA)-binding protein; involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(III) and 2-oxoglutarate; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0031418 - L-ascorbic acid binding [Evidence IEA,IEA]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_function: GO:0016706 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA] [PMID 20040577]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IMP] [PMID 16809762]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006415 - translational termination [Evidence IMP] [PMID 16809762]; GO_process: GO:0006415 - translational termination [Evidence IMP] [PMID 20630870]
AWJ20_3131	BAR domain-containing protein that localizes to Golgi vesicles; the Golgi vesicles it localizes to are both early and late; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 16107716]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 18156177]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 18156177]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 18156177]
AWJ20_3132	Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; GO_component: GO:0070772 - PAS complex [Evidence IDA,IPI] [PMID 19037259]; GO_component: GO:0000306 - extrinsic component of vacuolar membrane [Evidence IDA] [PMID 11889142]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11889142]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14528018]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA,IMP] [PMID 19037259]; GO_process: GO:0006661 - phosphatidylinositol biosynthetic process [Evidence IGI,IMP] [PMID 11889142]; GO_process: GO:0033674 - positive regulation of kinase activity [Evidence IGI,IMP] [PMID 11889142]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3133	Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a; required for activation of RAN GTPase Gsp1p and dissociation of receptor-tRNA-Gsp1p export complex; recruits Rna1p from cytoplasm to NPC, facilitates Rna1p activation of Gsp1p GTPase activity by enabling Rna1p to gain access to Gsp1p-GTP bound to export receptor tRNA complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17203074]; GO_component: GO:0005643 - nuclear pore [Evidence IDA,IPI] [PMID 17203074]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 17203074]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI,IMP,IPI] [PMID 17203074]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IGI] [PMID 22008473]
AWJ20_3134	ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; interacts with YRA1; required for the assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22679025]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23721653]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA,IMP] [PMID 22679025]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:1990120 - messenger ribonucleoprotein complex assembly [Evidence IMP] [PMID 23721653]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IGI,IMP] [PMID 22679025]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IPI] [PMID 7883168]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11585918]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3137	Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 12514182]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IDA] [PMID 10622712]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IDA] [PMID 10622712]
AWJ20_3138	Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching; GO_component: GO:0034456 - UTP-C complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005956 - protein kinase CK2 complex [Evidence IDA] [PMID 8135547]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 8226802]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 11551505]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 20657825]; GO_process: GO:0007535 - donor selection [Evidence IGI] [PMID 22496671]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16952051]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IDA] [PMID 11551505]; GO_process: GO:0006359 - regulation of transcription from RNA polymerase III promoter [Evidence IDA] [PMID 11551505]
AWJ20_3139	Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 22575457]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 22575457]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2196438]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004016 - adenylate cyclase activity [Evidence IEA,IEA]; GO_function: GO:0004016 - adenylate cyclase activity [Evidence IDA] [PMID 2934138]; GO_function: GO:0004016 - adenylate cyclase activity [Evidence IMP] [PMID 6360999]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016849 - phosphorus-oxygen lyase activity [Evidence IEA]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IGI] [PMID 2934138]; GO_process: GO:0007188 - adenylate cyclase-modulating G-protein coupled receptor signaling pathway [Evidence IGI] [PMID 2934138]; GO_process: GO:0006171 - cAMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009190 - cyclic nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_3140	Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0032866 - D-xylose:NADP reductase activity [Evidence IDA,IMP] [PMID 11481678]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IEA]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA] [PMID 11525399]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA,IMP] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA,IMP] [PMID 12271459]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IDA] [PMID 11525399]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0019388 - galactose catabolic process [Evidence IGI] [PMID 18811659]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_3141	Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence ISS] [PMID 11380987]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
AWJ20_3143	Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8807288]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0017061 - S-methyl-5-thioadenosine phosphorylase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0017061 - S-methyl-5-thioadenosine phosphorylase activity [Evidence IDA,IMP] [PMID 14506228]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0004645 - phosphorylase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016763 - transferase activity, transferring pentosyl groups [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IDA,IMP] [PMID 14506228]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IMP] [PMID 8807288]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0006166 - purine ribonucleoside salvage [Evidence IEA]
AWJ20_3145	Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog, NDE1, that arose from the whole genome duplication; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISS] [PMID 9733747]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence ISS] [PMID 9696750]; GO_function: GO:0003954 - NADH dehydrogenase activity [Evidence ISS] [PMID 9733747]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 12032156]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IGI,IMP,ISS] [PMID 9733747]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3146	Microsomal cytochrome b reductase; not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H [Evidence IEA]; GO_function: GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H [Evidence IDA] [PMID 14930]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3147	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0004072 - aspartate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004072 - aspartate kinase activity [Evidence IDA,IMP] [PMID 18626862]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009090 - homoserine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IDA,IMP] [PMID 18626862]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 4380684]
AWJ20_3148	Plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR2 has a paralog, PSR1, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10777497]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence ISA] [PMID 10777497]; GO_process: GO:0071472 - cellular response to salt stress [Evidence IGI] [PMID 10777497]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3149	Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15367670]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 8508778]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8508778]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3150	Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15926887]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 17176761]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015386 - potassium:proton antiporter activity [Evidence IMP,ISS] [PMID 9811642]; GO_function: GO:0015299 - solute:proton antiporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015672 - monovalent inorganic cation transport [Evidence IMP,ISS] [PMID 9811642]; GO_process: GO:0006813 - potassium ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3153	Essential nuclear envelope integral membrane protein; required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11483521]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IGI] [PMID 20016074]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 11483521]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 11483521]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3154	Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005874 - microtubule [Evidence IDA] [PMID 22842922]; GO_component: GO:0005880 - nuclear microtubule [Evidence IDA] [PMID 7559759]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005819 - spindle [Evidence IDA] [PMID 7559759]; GO_component: GO:0051233 - spindle midzone [Evidence IDA] [PMID 7559759]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 12591913]; GO_process: GO:0000910 - cytokinesis [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 16615892]; GO_process: GO:0001578 - microtubule bundle formation [Evidence IDA] [PMID 12591913]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IEA]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 12591913]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IGI,IMP] [PMID 7559759]; GO_process: GO:0043148 - mitotic spindle stabilization [Evidence IMP] [PMID 9036857]; GO_process: GO:0051255 - spindle midzone assembly [Evidence IMP] [PMID 17562791]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 16688214]
AWJ20_3155	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase); catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008696 - 4-amino-4-deoxychorismate lyase activity [Evidence IEA]; GO_function: GO:0008696 - 4-amino-4-deoxychorismate lyase activity [Evidence IDA] [PMID 17873082]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IMP] [PMID 17873082]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA]
AWJ20_3156	Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IBA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0004647 - phosphoserine phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004647 - phosphoserine phosphatase activity [Evidence IMP] [PMID 1326413]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IMP] [PMID 1326413]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3158	Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to the cytosol in response to hypoxia; homolog of human ERCC3; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 7961739]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IDA] [PMID 8855246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0097550 - transcriptional preinitiation complex [Evidence IDA] [PMID 22751016]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 8202161]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IDA] [PMID 22751016]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0033683 - nucleotide-excision repair, DNA incision [Evidence IDA] [PMID 8631896]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 17212653]; GO_process: GO:0001111 - promoter clearance from RNA polymerase II promoter [Evidence IMP] [PMID 10713451]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 10713167]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0010525 - regulation of transposition, RNA-mediated [Evidence IMP] [PMID 10713167]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001113 - transcriptional open complex formation at RNA polymerase II promoter [Evidence IMP] [PMID 10409754]
AWJ20_3160	Putative histone acetylase with a role in transcriptional silencing; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence ISS] [PMID 9175471]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 16199888]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 17078097]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 21057056]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 21057056]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 21057056]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 12192040]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17526727]
AWJ20_3161	Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence ISS] [PMID 11380987]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
AWJ20_3162	Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence ISS] [PMID 11380987]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]
AWJ20_3164	1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis; GO_component: GO:0070772 - PAS complex [Evidence IDA,IPI] [PMID 19037259]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 11889142]; GO_component: GO:0010008 - endosome membrane [Evidence IDA] [PMID 9763421]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11889142]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9763421]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0000285 - 1-phosphatidylinositol-3-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0000285 - 1-phosphatidylinositol-3-phosphate 5-kinase activity [Evidence IMP] [PMID 9763421]; GO_function: GO:0000285 - 1-phosphatidylinositol-3-phosphate 5-kinase activity [Evidence IDA,IMP] [PMID 9811604]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 9702203]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IMP] [PMID 9763421]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA,IMP] [PMID 9811604]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_3165	Mitochondrial tyrosyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 3315228]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IGI,ISS] [PMID 3315228]; GO_process: GO:0070184 - mitochondrial tyrosyl-tRNA aminoacylation [Evidence IGI,ISS] [PMID 3315228]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation [Evidence IEA]
AWJ20_3167	Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003839 - gamma-glutamylcyclotransferase activity [Evidence IDA,IMP] [PMID 23070364]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IDA,IMP] [PMID 23070364]
AWJ20_3168	Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15090619]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15090619]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA,IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IDA] [PMID 15766245]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034963 - box C/D snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0034964 - box H/ACA snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 17991894]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,IMP] [PMID 17158880]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 17991894]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 17991894]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 22576366]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IDA,IMP,IPI] [PMID 19818713]
AWJ20_3169	Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19251690]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0047631 - ADP-ribose diphosphatase activity [Evidence IEA]; GO_function: GO:0047631 - ADP-ribose diphosphatase activity [Evidence IDA] [PMID 10542272]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0019693 - ribose phosphate metabolic process [Evidence IDA] [PMID 10542272]; GO_process: GO:0019693 - ribose phosphate metabolic process [Evidence IDA] [PMID 12370179]
AWJ20_3171	Putative aminopeptidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_3172	Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IC] [PMID 1427091]; GO_component: GO:0005829 - cytosol [Evidence IC] [PMID 2827121]; GO_component: GO:0005829 - cytosol [Evidence IC] [PMID 2838385]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004146 - dihydrofolate reductase activity [Evidence IEA,IEA]; GO_function: GO:0004146 - dihydrofolate reductase activity [Evidence IMP] [PMID 1427091]; GO_function: GO:0004146 - dihydrofolate reductase activity [Evidence IMP] [PMID 2827121]; GO_function: GO:0004146 - dihydrofolate reductase activity [Evidence IDA] [PMID 2838385]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0046452 - dihydrofolate metabolic process [Evidence IMP] [PMID 1427091]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IEA]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IMP] [PMID 1427091]
AWJ20_3174	XP_001275318|NAD dependent epimerase/dehydratase family protein [Aspergillus clavatus NRRL 1]
AWJ20_3176	Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS); GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 1656231]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004408 - holocytochrome-c synthase activity [Evidence IEA,IEA]; GO_function: GO:0004408 - holocytochrome-c synthase activity [Evidence IDA] [PMID 3034577]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0018063 - cytochrome c-heme linkage [Evidence IDA] [PMID 3034577]
AWJ20_3180	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog, NSG1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 16270032]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IGI] [PMID 16270032]
AWJ20_3182	Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids; GO_component: GO:0000445 - THO complex part of transcription export complex [Evidence IPI] [PMID 11979277]; GO_component: GO:0000446 - nucleoplasmic THO complex [Evidence IMP,IPI] [PMID 11060033]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11139493]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IDA] [PMID 12093753]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 11060033]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 11979277]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 12093753]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 17960421]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]
AWJ20_3183	Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids; GO_component: GO:0000445 - THO complex part of transcription export complex [Evidence IPI] [PMID 11979277]; GO_component: GO:0000446 - nucleoplasmic THO complex [Evidence IMP,IPI] [PMID 11060033]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11139493]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IDA] [PMID 12093753]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 11060033]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP] [PMID 18614048]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 11979277]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 12093753]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 17960421]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006283 - transcription-coupled nucleotide-excision repair [Evidence IMP] [PMID 17537816]
AWJ20_3185	Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 18806213]; GO_process: GO:0009967 - positive regulation of signal transduction [Evidence IMP] [PMID 18806213]
AWJ20_3186	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3189	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005952 - cAMP-dependent protein kinase complex [Evidence IDA,IPI] [PMID 12024012]; GO_component: GO:0005952 - cAMP-dependent protein kinase complex [Evidence IGI] [PMID 3036373]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12024012]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18417610]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004691 - cAMP-dependent protein kinase activity [Evidence IEA]; GO_function: GO:0004691 - cAMP-dependent protein kinase activity [Evidence IDA] [PMID 12024012]; GO_function: GO:0004691 - cAMP-dependent protein kinase activity [Evidence IGI,ISS] [PMID 3036373]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IGI,ISS] [PMID 3036373]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12150916]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0010737 - protein kinase A signaling [Evidence IGI] [PMID 20133652]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 12024012]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]
AWJ20_3192	Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3194	Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8509410]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033179 - proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IDA,IMP] [PMID 8509410]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]; GO_process: GO:0007034 - vacuolar transport [Evidence IDA,IMP] [PMID 8509410]
AWJ20_3195	Ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 11076031]; GO_process: GO:0010995 - free ubiquitin chain depolymerization [Evidence IMP] [PMID 11076031]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_3196	Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15470103]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9314530]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 9314530]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 9234668]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 17142567]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 9234668]
AWJ20_3198	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 9748433]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3199	Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 9712830]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015087 - cobalt ion transmembrane transporter activity [Evidence IMP] [PMID 1508175]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence ISS] [PMID 9075641]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IGI] [PMID 8058041]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 10856230]; GO_process: GO:0006824 - cobalt ion transport [Evidence IMP] [PMID 1508175]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IGI] [PMID 8058041]
AWJ20_3200	Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 15536122]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8948441]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0015505 - uracil:cation symporter activity [Evidence IDA] [PMID 8948441]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 8948441]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0015857 - uracil transport [Evidence IDA] [PMID 8948441]
AWJ20_3202	Ubiquitin-binding hypothetical protein; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3203	Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008703 - 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [Evidence IEA]; GO_function: GO:0008703 - 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [Evidence IDA] [PMID 23620735]; GO_function: GO:0008703 - 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [Evidence IMP] [PMID 4555411]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]
AWJ20_3204	Beta 6 subunit of the 20S proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019774 - proteasome core complex, beta-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IC] [PMID 9087403]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]
AWJ20_3206	Beta subunit of the oligosaccharyl transferase glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12860997]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 1724755]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IMP] [PMID 12974639]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 1724755]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IDA] [PMID 1724755]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IPI] [PMID 9405463]; GO_process: GO:0018279 - protein N-linked glycosylation via asparagine [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_3207	Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11094088]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11094088]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 9560389]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IEA]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IMP] [PMID 9438131]; GO_function: GO:0043812 - phosphatidylinositol-4-phosphate phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA] [PMID 10224048]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 9438131]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3208	Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11094088]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11094088]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 9560389]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IEA]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IMP] [PMID 9438131]; GO_function: GO:0043812 - phosphatidylinositol-4-phosphate phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA] [PMID 10224048]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 9438131]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3209	NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 18630881]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_function: GO:0031132 - serine 3-dehydrogenase activity [Evidence IDA] [PMID 12535615]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IC] [PMID 12535615]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_3210	NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 18630881]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_function: GO:0031132 - serine 3-dehydrogenase activity [Evidence IDA] [PMID 12535615]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IC] [PMID 12535615]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_3211	GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,IMP,IPI,ISS] [PMID 10508155]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 18809726]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IDA] [PMID 11118206]
AWJ20_3212	Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12732713]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9315670]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IEA]; GO_component: GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IDA] [PMID 10716984]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IDA] [PMID 16537479]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IEA,IEA]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10535923]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 10716984]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IDA] [PMID 11893751]; GO_function: GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IMP] [PMID 8552025]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 10535923]; GO_process: GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IDA] [PMID 5459124]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3214	Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 11169758]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3215	Cytoplasmic hypothetical protein; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3216	hypothetical protein; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence ISS] [PMID 10029995]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 19751518]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 10029995]
AWJ20_3217	Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress; GO_component: GO:0031011 - Ino80 complex [Evidence IEA]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3219	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
AWJ20_3227	Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16924500]; GO_component: GO:0005886 - plasma membrane [Evidence IMP] [PMID 9691030]; GO_function: GO:0015169 - glycerol-3-phosphate transmembrane transporter activity [Evidence IGI,IMP] [PMID 20133652]; GO_function: GO:0001406 - glycerophosphodiester transmembrane transporter activity [Evidence IDA] [PMID 16924500]; GO_function: GO:0001406 - glycerophosphodiester transmembrane transporter activity [Evidence IMP] [PMID 9691030]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015794 - glycerol-3-phosphate transport [Evidence IGI,IMP] [PMID 20133652]; GO_process: GO:0001407 - glycerophosphodiester transport [Evidence IDA] [PMID 16924500]; GO_process: GO:0001407 - glycerophosphodiester transport [Evidence IMP] [PMID 9691030]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 9691030]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3228	Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 7664728]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence ISS] [PMID 7664728]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008554 - sodium-exporting ATPase activity, phosphorylative mechanism [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA]; GO_process: GO:0006814 - sodium ion transport [Evidence ISS] [PMID 7664728]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 7664728]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3229	Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 1869583]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8144572]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 1869583]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 1400408]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 15342786]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9774392]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 10567418]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 15342786]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9674429]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1473150]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IMP] [PMID 1729605]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3230	Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031429 - box H/ACA snoRNP complex [Evidence IPI] [PMID 9472021]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IC] [PMID 9472021]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA] [PMID 15962000]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence ISA] [PMID 8710514]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IMP] [PMID 9472021]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0000495 - box H/ACA snoRNA 3'-end processing [Evidence IMP] [PMID 15964797]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9472021]; GO_process: GO:0031118 - rRNA pseudouridine synthesis [Evidence IMP] [PMID 9472021]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0031120 - snRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 15962000]
AWJ20_3231	Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype; GO_component: GO:0000813 - ESCRT I complex [Evidence IDA] [PMID 15044434]; GO_component: GO:0000813 - ESCRT I complex [Evidence IPI] [PMID 16615894]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0009898 - cytoplasmic side of plasma membrane [Evidence IDA] [PMID 20028738]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA,IPI] [PMID 11511343]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 19380877]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 17145965]; GO_process: GO:1902915 - negative regulation of protein polyubiquitination [Evidence IMP] [PMID 23645667]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP,IPI] [PMID 11511343]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 11511343]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
AWJ20_3233	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3235	Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 1618910]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IGI] [PMID 1618910]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007019 - microtubule depolymerization [Evidence IMP] [PMID 19041752]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IGI] [PMID 7860634]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 9813090]; GO_process: GO:0030541 - plasmid partitioning [Evidence IMP] [PMID 19364922]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 9813090]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618897]; GO_process: GO:0000073 - spindle pole body separation [Evidence IGI] [PMID 1618910]
AWJ20_3236	Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence TAS] [PMID 11717306]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033180 - proton-transporting V-type ATPase, V1 domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
AWJ20_3238	Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16204239]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0032217 - riboflavin transporter activity [Evidence IGI] [PMID 16204239]; GO_process: GO:0032218 - riboflavin transport [Evidence IGI] [PMID 16204239]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3240	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 20581295]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0001128 - RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IPI] [PMID 10906145]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 17603098]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 10906145]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7899074]; GO_process: GO:1901717 - positive regulation of gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:1901714 - positive regulation of urea catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_3241	Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003941 - L-serine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0003941 - L-serine ammonia-lyase activity [Evidence IDA] [PMID 7042346]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0004794 - L-threonine ammonia-lyase activity [Evidence IDA] [PMID 7042346]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0006565 - L-serine catabolic process [Evidence IGI] [PMID 7042346]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0006567 - threonine catabolic process [Evidence IGI] [PMID 7042346]
AWJ20_3246	Protein localized to COPII-coated vesicles; forms a complex with Erv41p; involved in the membrane fusion stage of transport; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 11157978]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11157978]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_3249	Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
AWJ20_3251	Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_3252	Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 10094313]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IPI] [PMID 10733567]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9372940]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10094313]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10094313]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10094313]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3254	Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 3281936]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence ISS] [PMID 2675832]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IDA] [PMID 3281936]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0015923 - mannosidase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence ISS] [PMID 2675832]; GO_process: GO:0006013 - mannose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009313 - oligosaccharide catabolic process [Evidence IMP] [PMID 12723970]
AWJ20_3255	Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11481671]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 11481671]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0004143 - diacylglycerol kinase activity [Evidence IDA] [PMID 18458075]; GO_function: GO:0004143 - diacylglycerol kinase activity [Evidence IDA] [PMID 18458076]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006654 - phosphatidic acid biosynthetic process [Evidence IMP] [PMID 18458075]; GO_process: GO:0006654 - phosphatidic acid biosynthetic process [Evidence IDA] [PMID 18458076]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_3256	hypothetical protein that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IEA]; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3257	Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23874617]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 23874617]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 23874617]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3258	Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IEP] [PMID 3540611]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3260	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3261	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IEA]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001055 - RNA polymerase II activity [Evidence IDA] [PMID 8288647]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3299050]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0019985 - translesion synthesis [Evidence IMP] [PMID 22405652]
AWJ20_3262	Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23047103]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015809 - arginine transport [Evidence IGI,IMP] [PMID 23047103]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3263	Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 16782016]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10364461]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10579719]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 10364461]; GO_component: GO:0005940 - septin ring [Evidence IDA] [PMID 10579719]; GO_function: GO:0031386 - protein tag [Evidence IDA] [PMID 10364461]; GO_function: GO:0031386 - protein tag [Evidence IDA] [PMID 10579719]; GO_process: GO:0016925 - protein sumoylation [Evidence IDA] [PMID 9312010]
AWJ20_3264	Asn and gln rich hypothetical protein; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3266	Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0004108 - citrate (Si)-synthase activity [Evidence IEA,IEA]; GO_function: GO:0004108 - citrate (Si)-synthase activity [Evidence IDA,IMP] [PMID 17570335]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0046912 - transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Evidence IEA]; GO_process: GO:0046356 - acetyl-CoA catabolic process [Evidence IDA,IMP] [PMID 17570335]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006101 - citrate metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
AWJ20_3267	hypothetical protein; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 10923024]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IMP] [PMID 15002745]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3268	Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 22343720]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 22343720]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0034968 - histone lysine methylation [Evidence IDA,IMP] [PMID 22343720]; GO_process: GO:0032259 - methylation [Evidence IEA]
AWJ20_3269	hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3270	Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9412460]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9545233]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IPI] [PMID 9545233]; GO_process: GO:0006404 - RNA import into nucleus [Evidence IMP] [PMID 16040803]; GO_process: GO:0006404 - RNA import into nucleus [Evidence IMP] [PMID 17409072]; GO_process: GO:0006403 - RNA localization [Evidence IMP] [PMID 12167699]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006609 - mRNA-binding (hnRNP) protein import into nucleus [Evidence IMP,IPI,ISS] [PMID 9412460]; GO_process: GO:0006609 - mRNA-binding (hnRNP) protein import into nucleus [Evidence IMP,IPI,ISS] [PMID 9545233]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,IPI,ISS] [PMID 9412460]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,IPI,ISS] [PMID 9545233]; GO_process: GO:0051031 - tRNA transport [Evidence IMP] [PMID 17409072]; GO_process: GO:0051031 - tRNA transport [Evidence IMP] [PMID 20032305]
AWJ20_3271	5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030272 - 5-formyltetrahydrofolate cyclo-ligase activity [Evidence IEA,IEA]; GO_function: GO:0030272 - 5-formyltetrahydrofolate cyclo-ligase activity [Evidence IDA] [PMID 11923304]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IDA] [PMID 11923304]
AWJ20_3272	Cytosolic branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; BAT2 has a paralog, BAT1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21267457]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0052656 - L-isoleucine transaminase activity [Evidence IEA]; GO_function: GO:0052654 - L-leucine transaminase activity [Evidence IEA]; GO_function: GO:0052655 - L-valine transaminase activity [Evidence IEA]; GO_function: GO:0004084 - branched-chain-amino-acid transaminase activity [Evidence IEA,IEA]; GO_function: GO:0004084 - branched-chain-amino-acid transaminase activity [Evidence IDA] [PMID 8798704]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IDA,IMP] [PMID 8798704]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IMP] [PMID 8702755]; GO_process: GO:0009081 - branched-chain amino acid metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
AWJ20_3274	Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 12972564]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 12972564]; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 11259593]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12972564]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 12972564]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 11259593]; GO_process: GO:0008360 - regulation of cell shape [Evidence IGI] [PMID 11259593]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 12972564]
AWJ20_3275	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome; plays a role in the formation of mutant huntingtin (Htt) aggregates in yeast; GO_component: GO:0000814 - ESCRT II complex [Evidence IDA] [PMID 12194858]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 15029239]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 19380877]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000433 - negative regulation of transcription from RNA polymerase II promoter by glucose [Evidence IMP] [PMID 11278625]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12194858]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
AWJ20_3276	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]
AWJ20_3277	Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p; GO_component: GO:0048476 - Holliday junction resolvase complex [Evidence IDA] [PMID 17363897]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP,IPI] [PMID 10905349]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008821 - crossover junction endodeoxyribonuclease activity [Evidence IDA] [PMID 17363897]; GO_function: GO:0004520 - endodeoxyribonuclease activity [Evidence IDA] [PMID 11641278]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA,IEA]; GO_process: GO:0006259 - DNA metabolic process [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI] [PMID 12032096]; GO_process: GO:0006265 - DNA topological change [Evidence IGI] [PMID 11139495]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 11139495]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IGI,IMP] [PMID 23071463]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI] [PMID 11641278]; GO_process: GO:0000712 - resolution of meiotic recombination intermediates [Evidence IGI] [PMID 18691964]
AWJ20_3279	Subunit of a heterodimeric peroxisomal ABC transport complex; required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; complex also includes Pxa1p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 9395310]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IDA] [PMID 9395310]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:1902001 - fatty acid transmembrane transport [Evidence IDA] [PMID 9395310]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3280	Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IEA]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IMP] [PMID 10589830]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IDA] [PMID 17580971]; GO_function: GO:0004130 - cytochrome-c peroxidase activity [Evidence IDA,IMP] [PMID 21334283]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 10589830]; GO_process: GO:0042744 - hydrogen peroxide catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
AWJ20_3282	Enhanced Adherence to Polystyrene; similar to S. pombe predicted GPI-anchored SPBPJ4664.02; similar to RBT1; internal hexapeptide PATEST repeat region is expanded in allelic CaP19.8979; identical to C. albicans morphogenetic related gene CPH3 (AAM46085); no clear allele
AWJ20_3283	Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 12707309]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IDA,IGI,IMP] [PMID 12707309]
AWJ20_3284	Protein localized to COPII-coated vesicles; forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0033116 - endoplasmic reticulum-Golgi intermediate compartment membrane [Evidence IEA]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 11157978]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 11157978]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_3286	One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IGI] [PMID 12475929]; GO_function: GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IDA] [PMID 12799450]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 12799450]
AWJ20_3290	Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 11706015]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016866 - intramolecular transferase activity [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000250 - lanosterol synthase activity [Evidence IEA]; GO_function: GO:0000250 - lanosterol synthase activity [Evidence IMP] [PMID 18842050]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]
AWJ20_3294	3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12206772]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12206772]; GO_function: GO:0046568 - 3-methylbutanol:NAD(P) oxidoreductase activity [Evidence IEA]; GO_function: GO:0046568 - 3-methylbutanol:NAD(P) oxidoreductase activity [Evidence IMP] [PMID 16999827]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0043892 - methylglyoxal reductase (NADPH-dependent) activity [Evidence IEA]; GO_function: GO:0043892 - methylglyoxal reductase (NADPH-dependent) activity [Evidence IDA] [PMID 12722185]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0008204 - ergosterol metabolic process [Evidence IGI,IMP] [PMID 16598690]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 16999827]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_3297	Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12686616]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 196563]; GO_component: GO:0042597 - periplasmic space [Evidence IDA] [PMID 22833678]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0042132 - fructose 1,6-bisphosphate 1-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0042132 - fructose 1,6-bisphosphate 1-phosphatase activity [Evidence IMP] [PMID 2841162]; GO_function: GO:0042132 - fructose 1,6-bisphosphate 1-phosphatase activity [Evidence IDA] [PMID 6304022]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 6321183]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0072593 - reactive oxygen species metabolic process [Evidence IMP] [PMID 16199065]
AWJ20_3298	Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 11536335]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11536335]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 11536335]
AWJ20_3299	Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity; GO_component: GO:0005730 - nucleolus [Evidence IC] [PMID 16449634]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 18975973]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3300	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence ISS] [PMID 11864607]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12702244]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IPI] [PMID 11864606]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IGI] [PMID 7748491]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 11864606]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence ISS] [PMID 11864607]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3301	RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11526110]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11526110]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 9702203]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 11526110]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 11526110]
AWJ20_3303	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0004475 - mannose-1-phosphate guanylyltransferase activity [Evidence IEA]; GO_function: GO:0004475 - mannose-1-phosphate guanylyltransferase activity [Evidence IDA,IMP] [PMID 9195935]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IDA,IMP] [PMID 9195935]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 11055399]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9195935]
AWJ20_3304	Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID); GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IDA] [PMID 12008673]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0005850 - eukaryotic translation initiation factor 2 complex [Evidence IMP] [PMID 8417348]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IMP] [PMID 8947054]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 22683627]; GO_function: GO:0000049 - tRNA binding [Evidence IMP] [PMID 8947054]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 23063529]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA] [PMID 22683627]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0045903 - positive regulation of translational fidelity [Evidence IMP] [PMID 9308967]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 23063529]
AWJ20_3307	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IEA]; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IDA] [PMID 9620854]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IEA]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IPI] [PMID 17881380]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IDA] [PMID 9620854]; GO_component: GO:0030677 - ribonuclease P complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 23700311]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IDA] [PMID 17881380]; GO_function: GO:0000171 - ribonuclease MRP activity [Evidence IMP] [PMID 9085845]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IMP] [PMID 9085845]; GO_function: GO:0004540 - ribonuclease activity [Evidence IEA]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0034965 - intronic box C/D snoRNA processing [Evidence IDA] [PMID 18713869]; GO_process: GO:0006379 - mRNA cleavage [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 14729943]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9085845]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9085845]
AWJ20_3308	Putative lipoate-protein ligase; required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19570983]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016979 - lipoate-protein ligase activity [Evidence ISA] [PMID 19570983]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0009249 - protein lipoylation [Evidence IEA]; GO_process: GO:0009249 - protein lipoylation [Evidence IMP] [PMID 19570983]
AWJ20_3309	S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 21858014]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IMP] [PMID 22522802]; GO_process: GO:0018022 - peptidyl-lysine methylation [Evidence IMP] [PMID 22522802]
AWJ20_3310	Outer mitochondrial carnitine acetyltransferase; minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 18427809]; GO_function: GO:0004092 - carnitine O-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004092 - carnitine O-acetyltransferase activity [Evidence ISS] [PMID 11329169]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0006066 - alcohol metabolic process [Evidence IGI] [PMID 11329169]; GO_process: GO:0009437 - carnitine metabolic process [Evidence IMP] [PMID 11329169]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3311	3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IEA]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IDA,ISS] [PMID 12697341]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12697341]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006574 - valine catabolic process [Evidence IEA]
AWJ20_3312	Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 385049]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 385049]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 16246728]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence ISA] [PMID 17901157]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3313	Alpha arrestin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 20739461]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 20739461]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 20956561]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IPI] [PMID 18976803]; GO_process: GO:2000397 - positive regulation of ubiquitin-dependent endocytosis [Evidence IMP] [PMID 20956561]; GO_process: GO:0032386 - regulation of intracellular transport [Evidence IMP] [PMID 20739461]; GO_process: GO:0070086 - ubiquitin-dependent endocytosis [Evidence ISA] [PMID 18976803]
AWJ20_3315	Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence IEA,IEA]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence IDA,ISS] [PMID 10600168]; GO_function: GO:0004489 - methylenetetrahydrofolate reductase (NAD(P)H) activity [Evidence ISS] [PMID 8896269]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP,ISS] [PMID 10029993]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP,ISS] [PMID 10600168]; GO_process: GO:0006555 - methionine metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
AWJ20_3318	Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication; GO_component: GO:0008623 - CHRAC [Evidence IPI] [PMID 14673157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence TAS] [PMID 12370299]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 14673157]; GO_process: GO:0046020 - negative regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IMP] [PMID 12624196]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3319	GTPase required for ribosomal subunit synthesis and rRNA processing; required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA,IMP] [PMID 16307926]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,IMP] [PMID 16307926]; GO_function: GO:0034511 - U3 snoRNA binding [Evidence IDA] [PMID 16307926]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IDA] [PMID 11565749]; GO_process: GO:0042255 - ribosome assembly [Evidence IDA] [PMID 11565749]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
AWJ20_3320	Subunit a of the vacuolar-ATPase V0 domain; one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11592965]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11948198]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 11592965]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033179 - proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence IDA,ISS] [PMID 7514599]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IGI,ISS] [PMID 7514599]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IEP,IGI,IMP,ISS] [PMID 11278748]; GO_process: GO:0007035 - vacuolar acidification [Evidence IGI] [PMID 7514599]
AWJ20_3322	Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog, STB2, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3323	Putative histone acetylase with a role in transcriptional silencing; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence ISS] [PMID 9175471]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 16199888]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 17078097]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 21057056]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 21057056]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 21057056]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 12192040]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17526727]
AWJ20_3324	Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore assembly and clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Scp24p, and Spc25p; modified by sumoylation; GO_component: GO:0031262 - Ndc80 complex [Evidence IDA,IPI] [PMID 11179222]; GO_component: GO:0031262 - Ndc80 complex [Evidence IDA] [PMID 11266451]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IMP,IPI] [PMID 11179222]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 11511347]; GO_component: GO:0000780 - condensed nuclear chromosome, centromeric region [Evidence IDA,IGI,IPI] [PMID 11266451]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI,IMP] [PMID 11266451]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IMP] [PMID 19893618]
AWJ20_3325	Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004592 - pantoate-beta-alanine ligase activity [Evidence IEA,IEA]; GO_function: GO:0004592 - pantoate-beta-alanine ligase activity [Evidence IDA,ISS] [PMID 10417331]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]
AWJ20_3326	DEAH-box RNA helicase involved in second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 1825134]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 1825134]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 1825134]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000378 - RNA exon ligation [Evidence IDA] [PMID 23685439]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 16103217]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 1825134]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_3327	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
AWJ20_3329	GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog, SKI7, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 20947765]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 21623367]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 19481524]; GO_process: GO:0070966 - nuclear-transcribed mRNA catabolic process, no-go decay [Evidence IGI] [PMID 16554824]; GO_process: GO:0045727 - positive regulation of translation [Evidence IMP] [PMID 24424461]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0032790 - ribosome disassembly [Evidence IDA] [PMID 20947765]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA]
AWJ20_3332	Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9418908]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16009135]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 9418908]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0033328 - peroxisome membrane targeting sequence binding [Evidence IPI] [PMID 16679311]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16679311]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9418908]; GO_process: GO:0032581 - ER-dependent peroxisome organization [Evidence IMP] [PMID 20427571]; GO_process: GO:0045033 - peroxisome inheritance [Evidence IPI] [PMID 22486971]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0032527 - protein exit from endoplasmic reticulum [Evidence IMP] [PMID 16009135]; GO_process: GO:0045046 - protein import into peroxisome membrane [Evidence IMP] [PMID 10637226]; GO_process: GO:0050821 - protein stabilization [Evidence IPI] [PMID 16679311]
AWJ20_3333	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3335	Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3337	TFIIE small subunit; involved in RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IEA]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IDA] [PMID 1429681]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IDA] [PMID 7961670]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IPI] [PMID 9188494]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 8702741]; GO_function: GO:0001097 - TFIIH-class transcription factor binding [Evidence IDA] [PMID 8702741]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 9271406]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 1429681]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 7961670]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI] [PMID 9405484]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3338	Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 9182565]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 9182565]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0015432 - bile acid-exporting ATPase activity [Evidence IMP] [PMID 9182565]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015721 - bile acid and bile salt transport [Evidence IMP] [PMID 9182565]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3339	Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 22912589]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 9990856]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10028182]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9990856]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0000755 - cytogamy [Evidence IMP] [PMID 10028182]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 17229992]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 9990856]; GO_process: GO:0009847 - spore germination [Evidence IMP] [PMID 10028182]
AWJ20_3340	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10660071]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10660071]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 15215336]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IPI] [PMID 15215336]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA,IEA]
AWJ20_3344	Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16936141]; GO_function: GO:0045174 - glutathione dehydrogenase (ascorbate) activity [Evidence IEA]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IEA]; GO_function: GO:0004364 - glutathione transferase activity [Evidence IDA,ISS] [PMID 16709151]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006749 - glutathione metabolic process [Evidence ISS] [PMID 16709151]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_3346	Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0050236 - pyridoxine:NADP 4-dehydrogenase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0042820 - vitamin B6 catabolic process [Evidence IEA]
AWJ20_3347	Predicted membrane protein required for lumenal ER protein retention; mutants secrete the endogenous ER protein, BiP (Kar2p); GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 2178921]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 2178921]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 2178921]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3350	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; GO_component: GO:0005952 - cAMP-dependent protein kinase complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11134339]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11134339]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18417610]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3288487]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2831892]; GO_function: GO:0030552 - cAMP binding [Evidence IEA]; GO_function: GO:0004862 - cAMP-dependent protein kinase inhibitor activity [Evidence IDA] [PMID 3037314]; GO_function: GO:0004862 - cAMP-dependent protein kinase inhibitor activity [Evidence IMP] [PMID 6292221]; GO_function: GO:0008603 - cAMP-dependent protein kinase regulator activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0046580 - negative regulation of Ras protein signal transduction [Evidence IDA,IMP] [PMID 3037314]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 2981630]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 3891097]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 12782684]; GO_process: GO:0045859 - regulation of protein kinase activity [Evidence IEA]; GO_process: GO:0001932 - regulation of protein phosphorylation [Evidence IEA]
AWJ20_3351	Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 10077188]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 18085829]
AWJ20_3352	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 8980231]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16461455]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 8980231]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA,IMP] [PMID 15870268]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 10329629]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3353	Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10196219]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 10196219]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 10196219]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 10196219]; GO_process: GO:0009408 - response to heat [Evidence IGI] [PMID 11589572]
AWJ20_3354	Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16760462]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IMP] [PMID 16760462]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IMP] [PMID 16760462]
AWJ20_3356	Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 11967269]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA,IEA]; GO_function: GO:0003995 - acyl-CoA dehydrogenase activity [Evidence IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence IEA,IEA]; GO_function: GO:0003997 - acyl-CoA oxidase activity [Evidence ISA] [PMID 2189786]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12819196]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence IEA]; GO_process: GO:0033540 - fatty acid beta-oxidation using acyl-CoA oxidase [Evidence ISA] [PMID 2189786]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA,IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3358	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15107529]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 16648468]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 19433447]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16648468]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 19433447]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI] [PMID 15107529]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IGI] [PMID 15107529]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IMP] [PMID 16651379]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IGI,IMP] [PMID 16648468]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 16651379]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3359	Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15167894]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11565749]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15167894]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IDA] [PMID 15167894]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12089522]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IMP] [PMID 11565749]
AWJ20_3360	Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p; GO_component: GO:0019897 - extrinsic component of plasma membrane [Evidence IDA] [PMID 11154269]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP,ISS] [PMID 16524914]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IDA] [PMID 16778074]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 16524914]; GO_process: GO:0016485 - protein processing [Evidence IDA] [PMID 16778074]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0043200 - response to amino acid [Evidence IGI,IMP] [PMID 11154269]
AWJ20_3364	Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway; GO_component: GO:0030126 - COPI vesicle coat [Evidence IEA]; GO_component: GO:0030126 - COPI vesicle coat [Evidence IMP,ISS] [PMID 8001155]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 9427388]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8001155]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
AWJ20_3365	Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IDA] [PMID 12008673]; GO_component: GO:0005850 - eukaryotic translation initiation factor 2 complex [Evidence IDA,IMP] [PMID 12137565]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 9858542]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 12137565]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 15145951]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 22683627]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 9395514]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IDA] [PMID 12008673]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IMP] [PMID 16449648]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
AWJ20_3369	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 3004948]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IDA] [PMID 3004948]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006089 - lactate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3371	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23651256]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence ISS] [PMID 10207060]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IDA] [PMID 23651256]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IEA]; GO_process: GO:0009074 - aromatic amino acid family catabolic process [Evidence IMP] [PMID 10207060]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10207060]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA]; GO_process: GO:0006572 - tyrosine catabolic process [Evidence IEA]
AWJ20_3372	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3378	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; SPT16 specifically required for diauxic shift-induced H2B deposition onto rDNA genes; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome; GO_component: GO:0035101 - FACT complex [Evidence IGI,IPI] [PMID 11432837]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 10413469]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10413469]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_component: GO:0008023 - transcription elongation factor complex [Evidence IPI] [PMID 12242279]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10413469]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 18089575]; GO_function: GO:0031491 - nucleosome binding [Evidence IDA] [PMID 11432837]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0034724 - DNA replication-independent nucleosome organization [Evidence IDA] [PMID 19683499]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IPI] [PMID 9199353]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 12952948]; GO_process: GO:0006334 - nucleosome assembly [Evidence IDA] [PMID 15082784]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA] [PMID 15987999]; GO_process: GO:0060261 - positive regulation of transcription initiation from RNA polymerase II promoter [Evidence IGI] [PMID 15987999]; GO_process: GO:0060261 - positive regulation of transcription initiation from RNA polymerase II promoter [Evidence IMP] [PMID 19574230]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 19683500]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IPI] [PMID 12242279]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3379	Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15537705]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15537705]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 9151665]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IGI] [PMID 15537705]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 9151665]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IMP] [PMID 9151665]
AWJ20_3383	mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21135132]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18923425]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15652485]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 15652485]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 15652485]
AWJ20_3387	Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9234705]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 9234705]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006448 - regulation of translational elongation [Evidence IMP,IPI] [PMID 9234705]
AWJ20_3388	Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 8524252]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 11046133]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 8524252]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3390	Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19793921]; GO_function: GO:0004107 - chorismate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004107 - chorismate synthase activity [Evidence IDA,IMP] [PMID 8971708]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0042602 - riboflavin reductase (NADPH) activity [Evidence IDA] [PMID 8971708]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IMP] [PMID 8971708]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_3391	Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 9679135]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005785 - signal recognition particle receptor complex [Evidence IPI] [PMID 9679135]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IPI] [PMID 7844142]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 7844142]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005047 - signal recognition particle binding [Evidence IMP,IPI,ISS] [PMID 9679135]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IC,TAS] [PMID 7844142]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 9679135]
AWJ20_3393	Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0032126 - eisosome [Evidence IDA] [PMID 19269952]; GO_component: GO:0032126 - eisosome [Evidence IDA,IGI] [PMID 20526336]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070941 - eisosome assembly [Evidence IMP] [PMID 20526336]
AWJ20_3394	Plasma membrane protein that may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA,IMP] [PMID 12015967]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 12015967]; GO_process: GO:0048017 - inositol lipid-mediated signaling [Evidence IGI] [PMID 12015967]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0007033 - vacuole organization [Evidence IGI] [PMID 12015967]
AWJ20_3395	Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 15343339]; GO_component: GO:0005634 - nucleus [Evidence ISS] [PMID 9393435]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 15343339]; GO_function: GO:0003677 - DNA binding [Evidence ISS] [PMID 9393435]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_3396	Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 17178117]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 11943201]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0017137 - Rab GTPase binding [Evidence IPI] [PMID 11943201]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3398	Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_function: GO:0004568 - chitinase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IGI] [PMID 18809304]
AWJ20_3399	Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16611745]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity [Evidence IMP] [PMID 11069666]; GO_function: GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity [Evidence IMP] [PMID 7939631]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006796 - phosphate-containing compound metabolic process [Evidence IMP] [PMID 4570606]
AWJ20_3400	Component of the SSU processome; SSU processome is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034457 - Mpp10 complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0032040 - small-subunit processome [Evidence IMP] [PMID 12242301]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA,IEA]; GO_function: GO:0030515 - snoRNA binding [Evidence ISS] [PMID 10409734]; GO_function: GO:0030515 - snoRNA binding [Evidence IDA] [PMID 15489263]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence TAS] [PMID 11087857]
AWJ20_3401	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3402	Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 17882259]; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 17882260]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP,IPI] [PMID 17882259]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IMP] [PMID 17882260]
AWJ20_3403	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence ISS] [PMID 1597181]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence ISS] [PMID 1597181]; GO_process: GO:0002181 - cytoplasmic translation [Evidence ISS] [PMID 1597181]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3404	Major karyopherin; involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0000776 - kinetochore [Evidence IDA] [PMID 19139260]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9891088]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 18573877]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 9323132]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 9857197]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 9323132]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 9323132]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IGI] [PMID 19139260]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11313466]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3407	Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults and preservation of normal mitochondrial function under damage-eliciting conditions; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12963738]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IMP,ISS] [PMID 12963738]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 12963738]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_3408	Basic zinc-finger protein; similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3409	Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 16135509]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 16267052]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24390141]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0047499 - calcium-independent phospholipase A2 activity [Evidence IDA,IMP] [PMID 20332534]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042171 - lysophosphatidic acid acyltransferase activity [Evidence IDA] [PMID 20332534]; GO_function: GO:0004771 - sterol esterase activity [Evidence IDA,IMP] [PMID 20332534]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 16135509]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 20332534]; GO_process: GO:0007114 - cell budding [Evidence IGI,IMP] [PMID 19150427]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IMP] [PMID 20332534]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI,IMP] [PMID 16267052]; GO_process: GO:0006642 - triglyceride mobilization [Evidence IDA,IMP] [PMID 16135509]
AWJ20_3411	3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0004617 - phosphoglycerate dehydrogenase activity [Evidence IEA]; GO_function: GO:0004617 - phosphoglycerate dehydrogenase activity [Evidence IMP] [PMID 12525494]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009070 - serine family amino acid biosynthetic process [Evidence IMP] [PMID 12525494]
AWJ20_3412	Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15210724]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000502 - proteasome complex [Evidence IEA,IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IMP] [PMID 7565784]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IPI] [PMID 12200120]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI] [PMID 17911101]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0042176 - regulation of protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP,IPI] [PMID 7565784]
AWJ20_3413	Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3414	Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14767053]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15282802]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 14767053]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 15282802]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23613772]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 14767053]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 14767053]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 23613772]; GO_function: GO:0005094 - Rho GDP-dissociation inhibitor activity [Evidence IGI,IPI] [PMID 15215315]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IMP] [PMID 14767053]; GO_process: GO:0035023 - regulation of Rho protein signal transduction [Evidence IGI,IPI] [PMID 15215315]
AWJ20_3416	Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 16107716]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 18194531]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 17178117]
AWJ20_3417	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3419	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bateria; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11158358]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11158358]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005739 - mitochondrion [Evidence IDA,IPI] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004365 - glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Evidence IEA]; GO_function: GO:0004365 - glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Evidence IDA] [PMID 3905788]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEP] [PMID 3905788]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IEP] [PMID 3905788]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3425	Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 24919400]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 24919400]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3427	Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8164662]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 8164662]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 9153234]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IDA] [PMID 8164662]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3428	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10022925]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 10022925]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 11105761]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 17347149]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11086007]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI] [PMID 23212245]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3429	Component of the CCR4-NOT1 core complex; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; GO_component: GO:0030015 - CCR4-NOT core complex [Evidence IPI] [PMID 10490603]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11889048]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7926748]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IDA,IGI,IMP] [PMID 11889048]; GO_process: GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening [Evidence IDA] [PMID 11889048]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IDA,IPI] [PMID 21406554]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9055077]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 2680756]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 10490603]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0000749 - response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 2099190]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 11404327]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3432	Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9851972]; GO_component: GO:0031515 - tRNA (m1A) methyltransferase complex [Evidence IEA]; GO_component: GO:0031515 - tRNA (m1A) methyltransferase complex [Evidence IDA,IPI] [PMID 10779558]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016429 - tRNA (adenine-N1-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0016429 - tRNA (adenine-N1-)-methyltransferase activity [Evidence IDA,IMP] [PMID 10779558]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 10779558]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_3433	Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 19370060]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 12794079]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3435	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; GO_component: GO:0005853 - eukaryotic translation elongation factor 1 complex [Evidence IEA]; GO_component: GO:0005853 - eukaryotic translation elongation factor 1 complex [Evidence IMP] [PMID 8420802]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 17925388]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_process: GO:1990145 - maintenance of translational fidelity [Evidence IMP] [PMID 10409717]; GO_process: GO:0032232 - negative regulation of actin filament bundle assembly [Evidence IDA] [PMID 19095653]; GO_process: GO:0006449 - regulation of translational termination [Evidence IGI] [PMID 19545407]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]; GO_process: GO:0006414 - translational elongation [Evidence IMP] [PMID 10409717]
AWJ20_3436	Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11452019]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030684 - preribosome [Evidence IDA] [PMID 17922018]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 11452019]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11452019]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3438	Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19061865]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9584198]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 8063738]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IDA] [PMID 8063738]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 9584198]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 9584198]; GO_process: GO:0043418 - homocysteine catabolic process [Evidence IDA,IMP] [PMID 16769724]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9374524]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0046677 - response to antibiotic [Evidence IDA] [PMID 8063738]
AWJ20_3439	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3440	5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0017168 - 5-oxoprolinase (ATP-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0017168 - 5-oxoprolinase (ATP-hydrolyzing) activity [Evidence IDA,IMP] [PMID 20402795]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IMP] [PMID 20349993]
AWJ20_3442	WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16221974]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 16221974]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3443	RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of the mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of the guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNA pol II pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is a single bifunctional polypeptide; CET1 has a paralog, CTL1, that arose from the whole genome duplication; GO_component: GO:0031533 - mRNA cap methyltransferase complex [Evidence IGI,IPI] [PMID 9710603]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004651 - polynucleotide 5'-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004651 - polynucleotide 5'-phosphatase activity [Evidence IDA] [PMID 17707331]; GO_function: GO:0004651 - polynucleotide 5'-phosphatase activity [Evidence IDA] [PMID 9345280]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IPI] [PMID 9345280]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0098507 - polynucleotide 5' dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0098501 - polynucleotide dephosphorylation [Evidence IDA] [PMID 9345280]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 24205062]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 24172134]
AWJ20_3444	Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IDA] [PMID 12401799]; GO_function: GO:0004371 - glycerone kinase activity [Evidence ISS] [PMID 9038161]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0050354 - triokinase activity [Evidence IEA]; GO_process: GO:0019588 - anaerobic glycerol catabolic process [Evidence IEA]; GO_process: GO:0097237 - cellular response to toxic substance [Evidence IMP] [PMID 12401799]; GO_process: GO:0019563 - glycerol catabolic process [Evidence ISS] [PMID 9038161]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_3445	Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16467472]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9799362]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11839825]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA,IMP] [PMID 16467472]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IMP] [PMID 11839825]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_process: GO:0071322 - cellular response to carbohydrate stimulus [Evidence IMP] [PMID 11839825]; GO_process: GO:0071322 - cellular response to carbohydrate stimulus [Evidence IMP] [PMID 16467472]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 16467472]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IDA,IMP] [PMID 11839825]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3448	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3449	ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10545109]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IMP,ISS] [PMID 11157982]; GO_function: GO:0019153 - protein-disulfide reductase (glutathione) activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16002399]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12881414]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 10545109]
AWJ20_3450	WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; facilitates N-terminus-dependent proteolysis of centromeric histone H3 (Cse4p) for faithful chromosome segregation; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA,IMP] [PMID 16428438]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IMP] [PMID 12399380]; GO_process: GO:0010992 - ubiquitin homeostasis [Evidence IMP] [PMID 18508771]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 2111732]
AWJ20_3453	Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8868422]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000170 - sphingosine hydroxylase activity [Evidence IMP,ISS] [PMID 9556590]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IMP,ISS] [PMID 9556590]
AWJ20_3454	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12034822]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12034822]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 12198175]; GO_function: GO:0000150 - recombinase activity [Evidence IDA,IMP] [PMID 12198175]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 19729448]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 12198175]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 19074198]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IDA] [PMID 12034822]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 12198175]; GO_process: GO:0090297 - positive regulation of mitochondrial DNA replication [Evidence IMP] [PMID 17116696]; GO_process: GO:0090297 - positive regulation of mitochondrial DNA replication [Evidence IMP] [PMID 19074198]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IPI] [PMID 9736700]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3455	Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IC] [PMID 9405463]; GO_function: GO:0004576 - oligosaccharyl transferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IPI] [PMID 9405463]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
AWJ20_3458	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0004784 - superoxide dismutase activity [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006801 - superoxide metabolic process [Evidence IEA]
AWJ20_3459	Essential nuclear envelope integral membrane protein; identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15882446]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 15882446]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 15882446]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence IMP] [PMID 15882446]; GO_process: GO:0006611 - protein export from nucleus [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 15882446]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3460	Vacuolar aminopeptidase Y; processed to mature form by Prb1p; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 8175799]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IDA] [PMID 8175799]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IMP] [PMID 8175800]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IDA] [PMID 8175799]
AWJ20_3461	Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IGI,IMP] [PMID 20630870]
AWJ20_3462	S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 10051442]; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 9003798]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0043115 - precorrin-2 dehydrogenase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004851 - uroporphyrin-III C-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004851 - uroporphyrin-III C-methyltransferase activity [Evidence IDA] [PMID 10051442]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 1101032]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019354 - siroheme biosynthetic process [Evidence IEA]; GO_process: GO:0019354 - siroheme biosynthetic process [Evidence IGI,ISS] [PMID 9003798]; GO_process: GO:0000103 - sulfate assimilation [Evidence NAS] [PMID 9003798]
AWJ20_3464	AN1-type zinc finger hypothetical protein; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element, a transcriptional profile similar to CUZ1 and RPN2, and decreased expression in an RPN4 mutant; induced by nitrogen limitation and weak acid; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071243 - cellular response to arsenic-containing substance [Evidence IMP] [PMID 24297164]
AWJ20_3465	Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000920 - cytokinetic cell separation [Evidence IGI] [PMID 16041152]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 11378903]
AWJ20_3466	DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9148890]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 9148890]; GO_function: GO:0051082 - unfolded protein binding [Evidence ISS] [PMID 9148890]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11381090]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 10069807]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 9817751]
AWJ20_3467	hypothetical protein; contains FYVE domain; similar to Fab1 and Vps27; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3468	Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene; GO_component: GO:0097344 - Rix1 complex [Evidence IDA] [PMID 14759368]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15528184]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 22421151]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 22421151]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12089522]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 14759368]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 22421151]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 15528184]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3469	Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Tae2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 23479637]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 23479637]
AWJ20_3470	Cystathionine gamma-lyase; catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0080146 - L-cysteine desulfhydrase activity [Evidence IEA]; GO_function: GO:0044540 - L-cystine L-cysteine-lyase (deaminating) [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004123 - cystathionine gamma-lyase activity [Evidence IEA]; GO_function: GO:0004123 - cystathionine gamma-lyase activity [Evidence IMP] [PMID 10509018]; GO_function: GO:0004123 - cystathionine gamma-lyase activity [Evidence IDA] [PMID 1577698]; GO_function: GO:0004123 - cystathionine gamma-lyase activity [Evidence IMP] [PMID 8366024]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IMP] [PMID 8366024]; GO_process: GO:0019343 - cysteine biosynthetic process via cystathionine [Evidence IMP] [PMID 10509018]; GO_process: GO:0019346 - transsulfuration [Evidence IMP] [PMID 8366024]
AWJ20_3472	Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IPI] [PMID 10958688]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_function: GO:0000774 - adenyl-nucleotide exchange factor activity [Evidence IDA,IPI] [PMID 10958688]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IGI,IMP] [PMID 10958688]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3473	Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006020 - inositol metabolic process [Evidence IMP] [PMID 16582425]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
AWJ20_3474	Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 10359606]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence ISA] [PMID 10359606]
AWJ20_3475	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8016655]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA,IMP] [PMID 8159677]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 1339306]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA,IMP] [PMID 16461455]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0042393 - histone binding [Evidence IPI] [PMID 17496903]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 8016655]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8221926]; GO_process: GO:0044109 - cellular alcohol catabolic process [Evidence IMP] [PMID 1339306]; GO_process: GO:0031496 - positive regulation of mating type switching [Evidence IMP] [PMID 6436497]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 1339306]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3542227]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0005987 - sucrose catabolic process [Evidence IMP] [PMID 1339306]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3479	Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 19198597]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 19198597]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8849456]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IPI] [PMID 9488461]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 12524331]; GO_process: GO:0006609 - mRNA-binding (hnRNP) protein import into nucleus [Evidence IMP,IPI] [PMID 8849456]; GO_process: GO:0006609 - mRNA-binding (hnRNP) protein import into nucleus [Evidence IDA] [PMID 9488461]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,IPI] [PMID 8849456]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP,IPI] [PMID 19366694]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3480	Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3481	Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication; GO_component: GO:0097582 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [Evidence IDA] [PMID 12551906]; GO_component: GO:0097582 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [Evidence IPI] [PMID 21956107]; GO_component: GO:0097582 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [Evidence IPI] [PMID 8543034]; GO_component: GO:0097584 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex [Evidence IDA] [PMID 12551906]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IEA]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IDA,IGI] [PMID 21956107]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IGI,IMP,ISA] [PMID 7852348]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IGI,IMP] [PMID 8543034]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 18182384]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IGI] [PMID 21147851]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IEA]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IMP] [PMID 9184828]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IMP] [PMID 18182384]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI] [PMID 21231968]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI,IMP] [PMID 7852348]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI,IMP] [PMID 8543034]; GO_process: GO:0032527 - protein exit from endoplasmic reticulum [Evidence IGI] [PMID 21147851]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IGI] [PMID 21231968]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IGI,IMP] [PMID 23704572]
AWJ20_3483	Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin; GO_component: GO:0033588 - Elongator holoenzyme complex [Evidence IDA] [PMID 11689709]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032447 - protein urmylation [Evidence IMP] [PMID 14551258]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11689709]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3484	Dihydroxyacid dehydratase; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004160 - dihydroxy-acid dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0004160 - dihydroxy-acid dehydratase activity [Evidence IMP] [PMID 14124940]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IMP] [PMID 14124940]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
AWJ20_3486	Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 15189984]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23045398]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006067 - ethanol metabolic process [Evidence IMP] [PMID 15189984]
AWJ20_3488	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8858151]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9575221]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IEA]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 14761951]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA,IPI] [PMID 8858151]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 9575221]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14761951]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9575221]; GO_function: GO:0010485 - H4 histone acetyltransferase activity [Evidence IDA] [PMID 8858151]; GO_function: GO:0008080 - N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16612003]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 7559580]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 8858151]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 9575221]; GO_function: GO:0042393 - histone binding [Evidence IEA]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 8858151]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA,IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 10982821]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 15099519]; GO_process: GO:0016573 - histone acetylation [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 7559580]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 8858151]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 9575221]
AWJ20_3490	Processivity factor; required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 12402045]; GO_function: GO:0090302 - mitotic anaphase-promoting complex activity [Evidence IDA] [PMID 12402045]; GO_process: GO:0007092 - activation of mitotic anaphase-promoting complex activity [Evidence IDA,IMP] [PMID 12402045]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA,IMP] [PMID 12402045]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0031497 - chromatin assembly [Evidence IGI] [PMID 12399376]; GO_process: GO:0008054 - cyclin catabolic process [Evidence IMP] [PMID 9348530]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
AWJ20_3491	Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8631921]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IDA] [PMID 9020857]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9182588]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IGI] [PMID 9182588]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
AWJ20_3494	Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3495	Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004055 - argininosuccinate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004055 - argininosuccinate synthase activity [Evidence IDA] [PMID 2897249]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEP,IMP] [PMID 2897249]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]
AWJ20_3496	hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3497	Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 19893618]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_function: GO:0008017 - microtubule binding [Evidence IDA] [PMID 19893618]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9585415]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IMP] [PMID 19893618]; GO_process: GO:0034501 - protein localization to kinetochore [Evidence IMP] [PMID 19893618]; GO_process: GO:0031134 - sister chromatid biorientation [Evidence IMP] [PMID 19893618]
AWJ20_3498	Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8164662]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 8164662]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 9153234]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IDA] [PMID 8164662]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3499	Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005622 - intracellular [Evidence IC] [PMID 10931938]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IGI,IMP] [PMID 12954640]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence ISS] [PMID 9653120]; GO_process: GO:0006688 - glycosphingolipid biosynthetic process [Evidence IMP,ISS] [PMID 9323360]; GO_process: GO:0006675 - mannosyl-inositol phosphorylceramide metabolic process [Evidence IMP] [PMID 9323360]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence TAS] [PMID 10366774]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence IMP] [PMID 12954640]
AWJ20_3500	Methionyl-tRNA synthetase; forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 3905796]; GO_component: GO:0017102 - methionyl glutamyl tRNA synthetase complex [Evidence IDA] [PMID 11069915]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004825 - methionine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004825 - methionine-tRNA ligase activity [Evidence IDA] [PMID 3312199]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006431 - methionyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006431 - methionyl-tRNA aminoacylation [Evidence IDA] [PMID 3312199]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3501	Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 10092627]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 10092627]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 10092627]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 22408182]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 22408182]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 10092627]
AWJ20_3503	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IGI] [PMID 15280369]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IMP] [PMID 10212224]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IGI] [PMID 15280369]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 15470112]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009156 - ribonucleoside monophosphate biosynthetic process [Evidence IEA]
AWJ20_3505	Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005756 - mitochondrial proton-transporting ATP synthase, central stalk [Evidence IDA] [PMID 17082766]; GO_component: GO:0005756 - mitochondrial proton-transporting ATP synthase, central stalk [Evidence IMP,IPI,ISS] [PMID 8026496]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA,IEA]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 18722382]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP,ISS] [PMID 8026496]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,IPI,ISS] [PMID 8026496]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3506	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11113180]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11113180]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 10580002]; GO_process: GO:0000173 - inactivation of MAPK activity involved in osmosensory signaling pathway [Evidence IDA,IGI,IMP] [PMID 11113180]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IMP] [PMID 9529388]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 20400943]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 10580002]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 11113180]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IMP] [PMID 8196609]
AWJ20_3508	ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; N-myristoylation of Rpt2p at Gly2 is involved in regulating the proper intracellular distribution of proteasome activity by controlling the nuclear localization of the 26S proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15210724]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 7721833]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0036402 - proteasome-activating ATPase activity [Evidence IGI,IMP] [PMID 11430818]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:0043171 - peptide catabolic process [Evidence IMP] [PMID 9724628]; GO_process: GO:0045732 - positive regulation of protein catabolic process [Evidence IDA] [PMID 15135049]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0031503 - protein complex localization [Evidence IMP] [PMID 23102099]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9724628]
AWJ20_3509	Ubiquitin-conjugating enzyme; key E2 partner with Ubc4p for the anaphase-promoting complex (APC); mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress key E2 partner with Ubc4p for the anaphase-promoting complex (APC); GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 10848595]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,ISS] [PMID 2265617]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 10878801]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11134048]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 2265617]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IMP] [PMID 11134048]
AWJ20_3510	Mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0047547 - 2-methylcitrate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0047547 - 2-methylcitrate dehydratase activity [Evidence ISA] [PMID 9006051]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0019543 - propionate catabolic process [Evidence IEA]; GO_process: GO:0019629 - propionate catabolic process, 2-methylcitrate cycle [Evidence IEA]; GO_process: GO:0019629 - propionate catabolic process, 2-methylcitrate cycle [Evidence ISA] [PMID 9006051]; GO_process: GO:0019541 - propionate metabolic process [Evidence IMP] [PMID 11179416]
AWJ20_3511	Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 10818358]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0047953 - glycerol 2-dehydrogenase (NADP+) activity [Evidence IEA]; GO_function: GO:1990042 - glycerol dehydrogenase [NAD(P)+] activity [Evidence IMP] [PMID 22979944]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IDA] [PMID 17962934]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3512	F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IMP] [PMID 9736614]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 11080155]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 15775961]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11080155]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11080155]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 11259599]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 9346238]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA,IMP] [PMID 9819356]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 10213692]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence TAS] [PMID 9346231]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 10213692]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0000751 - cell cycle arrest in response to pheromone [Evidence IMP] [PMID 15942932]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0071406 - cellular response to methylmercury [Evidence IMP] [PMID 17141224]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 16093347]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IGI,IPI] [PMID 9499404]
AWJ20_3514	Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 17307817]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004835 - tubulin-tyrosine ligase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 17307817]
AWJ20_3515	Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 17307817]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004835 - tubulin-tyrosine ligase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 17307817]
AWJ20_3516	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IMP,ISS] [PMID 10788431]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 19496824]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IMP] [PMID 10652283]; GO_function: GO:0005427 - proton-dependent oligopeptide secondary active transmembrane transporter activity [Evidence IDA] [PMID 16149917]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA] [PMID 16149917]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence IEP] [PMID 11862495]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3517	C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8663358]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8663358]; GO_function: GO:0000254 - C-4 methylsterol oxidase activity [Evidence IEA]; GO_function: GO:0000254 - C-4 methylsterol oxidase activity [Evidence IDA] [PMID 8663358]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8663358]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_3519	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IEA]; GO_component: GO:0005680 - anaphase-promoting complex [Evidence IDA] [PMID 9469814]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0030332 - cyclin binding [Evidence IPI] [PMID 12413490]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16481473]; GO_process: GO:0031145 - anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 8895471]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP] [PMID 16481473]; GO_process: GO:0030071 - regulation of mitotic metaphase/anaphase transition [Evidence IEA]
AWJ20_3520	Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities; GO_component: GO:0033203 - DNA helicase A complex [Evidence IDA] [PMID 9341218]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 8257676]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 8257676]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 9341218]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 8257676]
AWJ20_3523	Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11983179]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008173 - RNA methyltransferase activity [Evidence IMP,ISS] [PMID 11983179]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009452 - 7-methylguanosine RNA capping [Evidence IEA]; GO_process: GO:0036261 - 7-methylguanosine cap hypermethylation [Evidence IMP] [PMID 11983179]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0001510 - RNA methylation [Evidence IMP] [PMID 11983179]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 21398639]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0017126 - nucleologenesis [Evidence IMP] [PMID 15340060]; GO_process: GO:0032210 - regulation of telomere maintenance via telomerase [Evidence IMP] [PMID 18273059]; GO_process: GO:0032210 - regulation of telomere maintenance via telomerase [Evidence IMP] [PMID 18840651]
AWJ20_3524	Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16556230]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16556230]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004813 - alanine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004813 - alanine-tRNA ligase activity [Evidence IGI,ISS] [PMID 7761427]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_process: GO:0006419 - alanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006419 - alanyl-tRNA aminoacylation [Evidence IGI,IMP] [PMID 7761427]; GO_process: GO:0070143 - mitochondrial alanyl-tRNA aminoacylation [Evidence IC] [PMID 16556230]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3525	Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005754 - mitochondrial proton-transporting ATP synthase, catalytic core [Evidence IDA] [PMID 17082766]; GO_component: GO:0005754 - mitochondrial proton-transporting ATP synthase, catalytic core [Evidence IMP] [PMID 6225776]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IDA] [PMID 15294286]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 18722382]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP,ISS] [PMID 6225776]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IMP] [PMID 2529856]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0046034 - ATP metabolic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP] [PMID 2529856]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,ISS] [PMID 6225776]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3527	Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005099 - Ras GTPase activator activity [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0008092 - cytoskeletal protein binding [Evidence IPI] [PMID 9950677]; GO_process: GO:0007015 - actin filament organization [Evidence IPI] [PMID 9950677]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000920 - cytokinetic cell separation [Evidence IMP] [PMID 9442111]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032320 - positive regulation of Ras GTPase activity [Evidence IEA]; GO_process: GO:0051056 - regulation of small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence TAS] [PMID 10652251]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_3530	Probable membrane protein; involved in phosphate transport; role in the maturation of secretory proteins; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 8709965]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006817 - phosphate ion transport [Evidence IEA]; GO_process: GO:0006817 - phosphate ion transport [Evidence IGI,IMP,ISS] [PMID 8709965]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 19433630]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3531	Ribonuclease H2 catalytic subunit; removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; role in ribonucleotide excision repair; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11029655]; GO_component: GO:0032299 - ribonuclease H2 complex [Evidence IDA] [PMID 14734815]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA,IEA]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IDA,IMP] [PMID 14734815]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence ISS] [PMID 9462832]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IDA,IGI] [PMID 10567561]; GO_process: GO:0016070 - RNA metabolic process [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_3532	Lysyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 330225]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IDA] [PMID 3888626]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IMP] [PMID 7628447]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IDA] [PMID 3888626]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IMP] [PMID 7628447]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3535	Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IEA,IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IDA,IMP] [PMID 19151091]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence ISS] [PMID 9153759]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19145231]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19151091]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_3536	Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IEA,IEA]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence IDA,IMP] [PMID 19151091]; GO_function: GO:0004792 - thiosulfate sulfurtransferase activity [Evidence ISS] [PMID 9153759]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19145231]; GO_process: GO:0002143 - tRNA wobble position uridine thiolation [Evidence IMP] [PMID 19151091]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_3537	Kinesin-related antiparallel sliding motor protein involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; also inhibits spindle elongation and promotes spindle disassembly in late anaphase; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 9693366]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IDA] [PMID 9693366]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906145]; GO_function: GO:0008574 - plus-end-directed microtubule motor activity [Evidence IDA] [PMID 16906148]; GO_function: GO:0070463 - tubulin-dependent ATPase activity [Evidence IDA] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IMP] [PMID 16906148]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI,IMP] [PMID 9281582]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 23851487]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 9813090]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IGI,IMP] [PMID 10525539]; GO_process: GO:0031115 - negative regulation of microtubule polymerization [Evidence IMP] [PMID 24616221]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 9693366]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906145]; GO_process: GO:0070462 - plus-end specific microtubule depolymerization [Evidence IDA] [PMID 16906148]; GO_process: GO:0032888 - regulation of mitotic spindle elongation [Evidence IMP] [PMID 24616221]; GO_process: GO:0090307 - spindle assembly involved in mitosis [Evidence IMP] [PMID 23851487]
AWJ20_3542	Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress; GO_component: GO:0071944 - cell periphery [Evidence IDA] [PMID 12869188]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 12869188]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24403601]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IGI,IMP] [PMID 9890948]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0043942 - negative regulation of sexual sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 24403601]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IGI] [PMID 9890948]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 10848624]; GO_process: GO:0015914 - phospholipid transport [Evidence IGI,IMP] [PMID 9890948]; GO_process: GO:0042493 - response to drug [Evidence IGI] [PMID 9890948]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IGI] [PMID 9890948]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3543	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 8670905]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA,IMP] [PMID 8649518]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 9705931]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [Evidence IMP] [PMID 9705931]
AWJ20_3544	Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8810273]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008559 - xenobiotic-transporting ATPase activity [Evidence IDA] [PMID 21207971]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015893 - drug transport [Evidence TAS] [PMID 11421285]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046677 - response to antibiotic [Evidence IEA]; GO_process: GO:0046898 - response to cycloheximide [Evidence IEA]; GO_process: GO:0042493 - response to drug [Evidence TAS] [PMID 11421285]; GO_process: GO:0042493 - response to drug [Evidence IMP] [PMID 17881724]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3549	Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IMP] [PMID 17173333]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence ISS] [PMID 9341119]; GO_process: GO:0009436 - glyoxylate catabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence ISS] [PMID 9341119]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3553	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11922628]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IMP] [PMID 11922628]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IMP] [PMID 11922628]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0032973 - amino acid export [Evidence IGI,IMP] [PMID 15590823]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IMP] [PMID 11922628]; GO_process: GO:0015718 - monocarboxylic acid transport [Evidence IMP] [PMID 11922628]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3555	Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8267570]; GO_function: GO:0015212 - cytidine transmembrane transporter activity [Evidence IDA,IMP] [PMID 10501935]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IDA] [PMID 9092500]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015861 - cytidine transport [Evidence IDA,IMP] [PMID 10501935]; GO_process: GO:0015856 - cytosine transport [Evidence IDA] [PMID 9092500]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0072530 - purine-containing compound transmembrane transport [Evidence IDA] [PMID 9092500]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3556	Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 8798516]; GO_function: GO:0000007 - low-affinity zinc ion transmembrane transporter activity [Evidence IMP,ISS] [PMID 8798516]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006831 - low-affinity zinc ion transport [Evidence IMP,ISS] [PMID 8798516]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0071577 - zinc ion transmembrane transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]
AWJ20_3557	Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10635561]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006486 - protein glycosylation [Evidence IDA,IMP] [PMID 10635561]
AWJ20_3559	Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10982841]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence IDA] [PMID 10982841]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IDA,TAS] [PMID 10982841]
AWJ20_3560	Plasma membrane hypothetical protein; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23019326]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 8417990]
AWJ20_3561	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IMP,ISS] [PMID 10788431]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 19496824]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IMP] [PMID 10652283]; GO_function: GO:0005427 - proton-dependent oligopeptide secondary active transmembrane transporter activity [Evidence IDA] [PMID 16149917]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA] [PMID 16149917]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence IEP] [PMID 11862495]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3562	Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17395151]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IMP] [PMID 12429834]; GO_process: GO:0015696 - ammonium transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEP,IMP] [PMID 12429834]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 12429834]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3563	Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17395151]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IMP] [PMID 12429834]; GO_process: GO:0015696 - ammonium transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEP,IMP] [PMID 12429834]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 12429834]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3564	Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress; GO_component: GO:0042764 - ascospore-type prospore [Evidence IDA] [PMID 18701287]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 9884239]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 18552279]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0072687 - meiotic spindle [Evidence IDA] [PMID 18826657]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 18826657]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 18826657]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 14993234]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032947 - protein complex scaffold [Evidence IDA] [PMID 15901837]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0010458 - exit from mitosis [Evidence IMP] [PMID 12699621]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IC] [PMID 10882120]; GO_process: GO:0000921 - septin ring assembly [Evidence IMP] [PMID 14993234]; GO_process: GO:0043934 - sporulation [Evidence IDA] [PMID 18701287]
AWJ20_3565	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 16239145]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 2060626]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 2060626]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 2060626]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3567	Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005576 - extracellular region [Evidence IEA,IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_3568	hypothetical protein; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21442317]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence ISS] [PMID 7756978]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0045892 - negative regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_3570	Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9687494]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005342 - organic acid transmembrane transporter activity [Evidence IDA] [PMID 10419965]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0015849 - organic acid transport [Evidence IDA] [PMID 10419965]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3571	Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008559 - xenobiotic-transporting ATPase activity [Evidence TAS] [PMID 10581358]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042493 - response to drug [Evidence TAS] [PMID 11421285]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3572	Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16); GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0031303 - integral component of endosome membrane [Evidence IDA] [PMID 9565594]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 9427746]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 11739407]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 10545112]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IGI] [PMID 18753406]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9427746]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IGI,IMP] [PMID 18753406]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006675 - mannosyl-inositol phosphorylceramide metabolic process [Evidence IGI,IMP] [PMID 18753406]; GO_process: GO:0032527 - protein exit from endoplasmic reticulum [Evidence IGI] [PMID 18753406]; GO_process: GO:0009306 - protein secretion [Evidence IMP] [PMID 22753847]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11739407]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_3573	RNA polymerase I second largest subunit A135; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0032549 - ribonucleoside binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IGI] [PMID 2023944]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3574	RNA polymerase I second largest subunit A135; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0032549 - ribonucleoside binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IGI] [PMID 2023944]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3577	similar to S.kluyveri pyd3 (AAK60518) beta-alanine synthase involved in pyrimidine catabolism; allele of CaO19.1369
AWJ20_3579	Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004057 - arginyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004057 - arginyltransferase activity [Evidence IDA,IMP] [PMID 2185248]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0016598 - protein arginylation [Evidence IEA]; GO_process: GO:0016598 - protein arginylation [Evidence IDA,IMP] [PMID 2185248]
AWJ20_3580	Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18625724]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 18625724]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IMP] [PMID 20802492]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IEA,IEA]; GO_process: GO:0010421 - hydrogen peroxide-mediated programmed cell death [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 18625724]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 20802492]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IEA]
AWJ20_3581	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 22454508]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0097038 - perinuclear endoplasmic reticulum [Evidence IDA] [PMID 22454508]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IEA]; GO_function: GO:0046027 - phospholipid:diacylglycerol acyltransferase activity [Evidence IEA]; GO_function: GO:0046027 - phospholipid:diacylglycerol acyltransferase activity [Evidence IDA] [PMID 10747858]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006672 - ceramide metabolic process [Evidence IDA,IMP] [PMID 22738231]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0019915 - lipid storage [Evidence IDA,IMP] [PMID 10747858]; GO_process: GO:0019432 - triglyceride biosynthetic process [Evidence IDA,IMP] [PMID 10747858]
AWJ20_3585	Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346238]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IMP] [PMID 9736614]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11080155]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11080155]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8164658]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042803 - protein homodimerization activity [Evidence IDA,IMP] [PMID 7929378]; GO_function: GO:0061630 - ubiquitin protein ligase activity [Evidence IDA] [PMID 9346238]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP,ISS] [PMID 2842867]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 9346239]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence TAS] [PMID 9346231]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 7954792]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 9736614]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051865 - protein autoubiquitination [Evidence IDA,IMP] [PMID 8383676]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IDA] [PMID 1848239]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]
AWJ20_3586	Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 11566870]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0000295 - adenine nucleotide transmembrane transporter activity [Evidence IMP] [PMID 11390660]; GO_function: GO:0000295 - adenine nucleotide transmembrane transporter activity [Evidence IDA] [PMID 11566870]; GO_process: GO:0015867 - ATP transport [Evidence IDA] [PMID 11566870]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IGI,IMP] [PMID 11390660]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IGI,IMP] [PMID 11566870]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IMP] [PMID 11390660]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3592	Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0001653 - peptide receptor activity [Evidence ISS] [PMID 15060275]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 15060275]
AWJ20_3593	Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10720331]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3311884]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000824 - inositol tetrakisphosphate 3-kinase activity [Evidence IDA] [PMID 10574768]; GO_function: GO:0000824 - inositol tetrakisphosphate 3-kinase activity [Evidence IDA] [PMID 10720331]; GO_function: GO:0000825 - inositol tetrakisphosphate 6-kinase activity [Evidence IDA] [PMID 11311242]; GO_function: GO:0000827 - inositol-1,3,4,5,6-pentakisphosphate kinase activity [Evidence IDA] [PMID 11311242]; GO_function: GO:0008440 - inositol-1,4,5-trisphosphate 3-kinase activity [Evidence IEA]; GO_function: GO:0008440 - inositol-1,4,5-trisphosphate 3-kinase activity [Evidence IMP] [PMID 10683435]; GO_function: GO:0000823 - inositol-1,4,5-trisphosphate 6-kinase activity [Evidence IEA]; GO_function: GO:0000823 - inositol-1,4,5-trisphosphate 6-kinase activity [Evidence IDA] [PMID 10574768]; GO_function: GO:0000823 - inositol-1,4,5-trisphosphate 6-kinase activity [Evidence IDA] [PMID 10720331]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0035004 - phosphatidylinositol 3-kinase activity [Evidence IDA] [PMID 16123124]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP,IPI] [PMID 10632874]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0032958 - inositol phosphate biosynthetic process [Evidence IDA] [PMID 10574768]; GO_process: GO:0032958 - inositol phosphate biosynthetic process [Evidence IDA] [PMID 11311242]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12828642]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 16123124]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12828642]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 10632874]; GO_process: GO:0000821 - regulation of arginine metabolic process [Evidence IMP] [PMID 11119723]; GO_process: GO:0000821 - regulation of arginine metabolic process [Evidence IMP] [PMID 2274024]; GO_process: GO:0000821 - regulation of arginine metabolic process [Evidence IMP] [PMID 8043104]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3597	Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008466 - glycogenin glucosyltransferase activity [Evidence IEA]; GO_function: GO:0008466 - glycogenin glucosyltransferase activity [Evidence IGI,ISS] [PMID 8524228]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IGI] [PMID 8524228]
AWJ20_3600	Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 18829863]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3601	Fructose 1,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; N-terminally propionylated in vivo; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16806052]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16806052]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_function: GO:0016832 - aldehyde-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004332 - fructose-bisphosphate aldolase activity [Evidence IEA,IEA]; GO_function: GO:0004332 - fructose-bisphosphate aldolase activity [Evidence IDA,IMP] [PMID 2647491]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 6384192]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 6384192]
AWJ20_3603	Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 16314430]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16314430]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IGI,IMP,IPI] [PMID 17041589]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 23078654]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 16314430]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 16314430]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 23078654]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IMP] [PMID 17041589]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3605	Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004852 - uroporphyrinogen-III synthase activity [Evidence IEA,IEA]; GO_function: GO:0004852 - uroporphyrinogen-III synthase activity [Evidence IMP,ISS] [PMID 7597845]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 14559249]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 18042043]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]; GO_process: GO:0033014 - tetrapyrrole biosynthetic process [Evidence IEA]
AWJ20_3606	Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IGI,IMP] [PMID 18957409]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0018026 - peptidyl-lysine monomethylation [Evidence IGI,IMP] [PMID 18957409]
AWJ20_3608	Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15456753]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IGI,IMP,ISS] [PMID 10567543]; GO_function: GO:0015036 - disulfide oxidoreductase activity [Evidence IDA] [PMID 12730244]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI,IMP] [PMID 10567543]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence TAS] [PMID 15382238]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 10567543]
AWJ20_3609	tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004000 - adenosine deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043829 - tRNA-specific adenosine-37 deaminase activity [Evidence IDA] [PMID 9707437]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 9707437]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_3610	Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IGI,IMP] [PMID 11747308]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence ISA] [PMID 11063681]; GO_function: GO:0004828 - serine-tRNA ligase activity [Evidence IGI] [PMID 11747308]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IGI] [PMID 11063681]; GO_process: GO:0070158 - mitochondrial seryl-tRNA aminoacylation [Evidence IGI] [PMID 11747308]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 11063681]; GO_process: GO:0097056 - selenocysteinyl-tRNA(Sec) biosynthetic process [Evidence IEA]; GO_process: GO:0006434 - seryl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3611	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 19578373]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IMP] [PMID 10395901]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IMP] [PMID 10395901]; GO_process: GO:0006997 - nucleus organization [Evidence IMP] [PMID 10395901]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 19578373]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23129771]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3612	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 19578373]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11238398]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IMP] [PMID 10395901]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IMP] [PMID 10395901]; GO_process: GO:0006997 - nucleus organization [Evidence IMP] [PMID 10395901]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 19578373]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IBA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23129771]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3615	Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence ISS] [PMID 9396823]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 12364601]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IGI] [PMID 12364601]
AWJ20_3616	Splicing factor; component of the U4/U6-U5 snRNP complex; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IEA]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]
AWJ20_3617	Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain; GO_component: GO:0031011 - Ino80 complex [Evidence IDA] [PMID 12887900]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 10817755]; GO_component: GO:0033100 - NuA3 histone acetyltransferase complex [Evidence IDA] [PMID 17157260]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IPI] [PMID 8668146]; GO_component: GO:0016592 - mediator complex [Evidence IPI] [PMID 7995524]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 12242279]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA,IPI] [PMID 15896708]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 7995524]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IDA] [PMID 14749386]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IC] [PMID 7995524]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 7995524]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 12887900]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 15896708]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 8668146]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10817755]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 12887900]; GO_process: GO:0001111 - promoter clearance from RNA polymerase II promoter [Evidence IC] [PMID 7995524]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IC] [PMID 7995524]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IC] [PMID 7995524]
AWJ20_3618	Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15728363]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15728363]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15728363]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8921898]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IDA] [PMID 17401378]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IMP,ISS] [PMID 8921898]; GO_function: GO:0005506 - iron ion binding [Evidence IMP,IPI] [PMID 15728363]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 15728363]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IDA] [PMID 17401378]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_3619	hypothetical protein; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3620	Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11604502]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISS] [PMID 8392589]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0070899 - mitochondrial tRNA wobble uridine modification [Evidence IMP] [PMID 15509579]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_3624	top hit is XP_007298107.1 originated in Stereum hirsutum FP-91666 SS1
AWJ20_3625	Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate; GO_component: GO:0043291 - RAVE complex [Evidence IPI] [PMID 11283612]; GO_component: GO:0043291 - RAVE complex [Evidence IPI] [PMID 11844802]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11283612]; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 15090613]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045022 - early endosome to late endosome transport [Evidence IGI,IMP] [PMID 15090613]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0043254 - regulation of protein complex assembly [Evidence IMP,IPI] [PMID 11283612]; GO_process: GO:0043254 - regulation of protein complex assembly [Evidence IGI,IMP] [PMID 11844802]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IGI,IMP] [PMID 11283612]; GO_process: GO:0007035 - vacuolar acidification [Evidence IGI,IMP] [PMID 11844802]
AWJ20_3627	Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; PRB1 has a paralog, YSP3, that arose from the whole genome duplication; GO_component: GO:0005619 - ascospore wall [Evidence IBA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence TAS] [PMID 2674123]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence TAS] [PMID 9529893]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042802 - identical protein binding [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence ISA] [PMID 3325823]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 377296]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 385314]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 2674123]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IBA,IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 2674123]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 2674123]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 385314]
AWJ20_3628	Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0034044 - exomer complex [Evidence IDA] [PMID 17000877]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030140 - trans-Golgi network transport vesicle [Evidence IDA] [PMID 16498409]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI] [PMID 16498409]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 8657162]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IGI,IPI] [PMID 16498409]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3629	Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IMP] [PMID 10336995]; GO_function: GO:0052917 - dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0006488 - dolichol-linked oligosaccharide biosynthetic process [Evidence IMP] [PMID 10336995]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 10336995]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 12460938]
AWJ20_3630	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog, CPR2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8377189]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0042277 - peptide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence ISS] [PMID 8377189]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]
AWJ20_3631	Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10818000]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9844639]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10747053]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3633	Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9325326]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 1628805]; GO_process: GO:0070072 - vacuolar proton-transporting V-type ATPase complex assembly [Evidence IMP] [PMID 9325326]
AWJ20_3634	Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
AWJ20_3637	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3638	Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 12459470]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 17686782]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12493772]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16141212]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16141212]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0017050 - D-erythro-sphingosine kinase activity [Evidence IDA] [PMID 9677363]; GO_function: GO:0003951 - NAD+ kinase activity [Evidence IEA]; GO_function: GO:0004143 - diacylglycerol kinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008481 - sphinganine kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019722 - calcium-mediated signaling [Evidence IMP] [PMID 11278643]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0046834 - lipid phosphorylation [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0007205 - protein kinase C-activating G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IDA] [PMID 9677363]
AWJ20_3640	Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII in osmotic shock; activates CDC28 by stimulating antisense RNA transcription; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; with Mrc1p defines novel S-phase checkpoint that prevent conflicts between DNA replication and transcription; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10817757]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10817757]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IDA] [PMID 10805732]; GO_function: GO:0004707 - MAP kinase activity [Evidence ISS] [PMID 7681220]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 24508389]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000165 - MAPK cascade [Evidence IEA,IEA]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 12455951]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IMP] [PMID 23158682]; GO_process: GO:0006972 - hyperosmotic response [Evidence IMP] [PMID 7681220]; GO_process: GO:0007231 - osmosensory signaling pathway [Evidence IMP] [PMID 7681220]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12743037]; GO_process: GO:0061393 - positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress [Evidence IMP] [PMID 24508389]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 10805732]; GO_process: GO:0033262 - regulation of nuclear cell cycle DNA replication [Evidence IDA] [PMID 23178807]; GO_process: GO:0061392 - regulation of transcription from RNA polymerase II promoter in response to osmotic stress [Evidence IDA] [PMID 23178807]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0046685 - response to arsenic-containing substance [Evidence IGI,IMP] [PMID 16885417]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3641	Vacuolar glutathione S-conjugate transporter; member of ATP-binding cassette family; ATPase activity required to support vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; has role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23658021]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 8692889]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0015127 - bilirubin transmembrane transporter activity [Evidence IGI,IMP] [PMID 10790694]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 10220408]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12383937]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 12755704]; GO_function: GO:0015431 - glutathione S-conjugate-exporting ATPase activity [Evidence IDA] [PMID 9217966]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015723 - bilirubin transport [Evidence IGI,IMP] [PMID 10790694]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046686 - response to cadmium ion [Evidence IEA]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 10220408]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 12755704]; GO_process: GO:0010038 - response to metal ion [Evidence IDA] [PMID 9217966]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 10790694]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 23658021]
AWJ20_3644	Conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 17989219]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3645	Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA] [PMID 2007123]; GO_component: GO:0005967 - mitochondrial pyruvate dehydrogenase complex [Evidence IDA,IPI] [PMID 9038189]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045254 - pyruvate dehydrogenase complex [Evidence IEA]; GO_function: GO:0004742 - dihydrolipoyllysine-residue acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004742 - dihydrolipoyllysine-residue acetyltransferase activity [Evidence IDA] [PMID 2271545]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0006086 - acetyl-CoA biosynthetic process from pyruvate [Evidence IDA] [PMID 7947791]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IEA]
AWJ20_3646	GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p; GO_component: GO:0030127 - COPII vesicle coat [Evidence IEA]; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IDA] [PMID 8451644]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0003400 - regulation of COPII vesicle coating [Evidence IDA] [PMID 8451644]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_3647	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells; GO_component: GO:0005619 - ascospore wall [Evidence IDA] [PMID 8636217]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 1993729]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 8791410]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 18826657]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 14597621]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IC] [PMID 10882120]; GO_process: GO:0000281 - mitotic cytokinesis [Evidence IDA] [PMID 12636916]; GO_process: GO:0000921 - septin ring assembly [Evidence IMP] [PMID 15282341]; GO_process: GO:0031107 - septin ring disassembly [Evidence IMP] [PMID 12429908]
AWJ20_3648	WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21880895]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 21880895]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 21880895]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_3650	Vacuolar membrane protein that is a subunit of the HOPS complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport; the homotypic vacuole fusion and vacuole protein sorting complex is also known as the HOPS complex; GO_component: GO:0030897 - HOPS complex [Evidence IPI] [PMID 10944212]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9111041]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IPI] [PMID 11062257]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IDA] [PMID 16601699]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IMP] [PMID 9184222]; GO_process: GO:0035542 - regulation of SNARE complex assembly [Evidence IDA] [PMID 18385512]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IDA] [PMID 18385512]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 9159129]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA,IMP] [PMID 10944212]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 9111041]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 12730205]
AWJ20_3651	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 12499351]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15039776]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 15039776]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 9199164]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005771 - multivesicular body [Evidence IMP] [PMID 14523026]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15623581]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15707981]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 6759873]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 15707981]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 6759873]; GO_process: GO:0015846 - polyamine transport [Evidence IMP] [PMID 15707981]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3652	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 12499351]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15039776]; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 15039776]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 9199164]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005771 - multivesicular body [Evidence IMP] [PMID 14523026]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15623581]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15707981]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IMP] [PMID 6759873]; GO_function: GO:0015203 - polyamine transmembrane transporter activity [Evidence IMP] [PMID 15707981]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 6759873]; GO_process: GO:0015846 - polyamine transport [Evidence IMP] [PMID 15707981]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3653	JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IEA]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IDA] [PMID 16362057]; GO_function: GO:0051864 - histone demethylase activity (H3-K36 specific) [Evidence IMP] [PMID 17369256]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0070544 - histone H3-K36 demethylation [Evidence IEA]; GO_process: GO:0016577 - histone demethylation [Evidence IDA] [PMID 16362057]; GO_process: GO:0016577 - histone demethylation [Evidence IMP] [PMID 17369256]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3654	Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway; GO_component: GO:0030126 - COPI vesicle coat [Evidence IEA]; GO_component: GO:0030126 - COPI vesicle coat [Evidence IMP,ISS] [PMID 8001155]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 9427388]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8001155]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
AWJ20_3656	Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 19927118]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 19927118]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 16227579]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 19927118]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI] [PMID 16945917]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IGI] [PMID 19801658]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IGI] [PMID 19927118]; GO_process: GO:0032781 - positive regulation of ATPase activity [Evidence IDA,IMP] [PMID 19927118]; GO_process: GO:0051096 - positive regulation of helicase activity [Evidence IDA,IMP] [PMID 19927118]; GO_process: GO:0006364 - rRNA processing [Evidence IGI] [PMID 19927118]
AWJ20_3658	Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11149920]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IDA,IMP] [PMID 11038174]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11038174]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 11149920]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 11149920]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0051697 - protein delipidation [Evidence IDA] [PMID 17632063]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 11149920]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 11149920]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3659	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA,IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 17391830]; GO_function: GO:0030145 - manganese ion binding [Evidence IDA] [PMID 17159918]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_3660	Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; GO_component: GO:0070772 - PAS complex [Evidence IDA,IPI] [PMID 19037259]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 11950935]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14528018]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 14528018]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IGI] [PMID 11950935]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA] [PMID 14528018]
AWJ20_3662	AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IDA,IMP] [PMID 16642040]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA,IMP] [PMID 16642040]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16642040]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 17150819]
AWJ20_3663	Protein involved in transcription termination by RNA polymerase II; interacts with exonuclease Rat1p and Rai1p; has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15565157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0035861 - site of double-strand break [Evidence IDA] [PMID 22355353]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 15565157]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 20818393]; GO_process: GO:0042769 - DNA damage response, detection of DNA damage [Evidence IMP] [PMID 22355353]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IGI,IMP] [PMID 15565157]; GO_process: GO:0010526 - negative regulation of transposition, RNA-mediated [Evidence IMP] [PMID 11779788]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3666	Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 10512869]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005796 - Golgi lumen [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 15504911]; GO_function: GO:0051020 - GTPase binding [Evidence IDA] [PMID 15504911]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10512869]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10562277]; GO_process: GO:0000042 - protein targeting to Golgi [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_3667	Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IEA]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IDA] [PMID 7651383]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 8995429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 8770585]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1346062]; GO_process: GO:0006298 - mismatch repair [Evidence IGI] [PMID 9504910]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IMP] [PMID 6749598]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IMP] [PMID 6749599]; GO_process: GO:0000278 - mitotic cell cycle [Evidence IGI] [PMID 7516465]
AWJ20_3669	Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; GO_component: GO:0000243 - commitment complex [Evidence IPI] [PMID 10072386]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005846 - nuclear cap binding complex [Evidence IEA]; GO_component: GO:0005846 - nuclear cap binding complex [Evidence IDA] [PMID 8811086]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 22072789]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0000339 - RNA cap binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 10072386]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IEA]; GO_process: GO:0016070 - RNA metabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0045292 - mRNA cis splicing, via spliceosome [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10072386]; GO_process: GO:0051028 - mRNA transport [Evidence IEA,IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IDA,IPI] [PMID 15753296]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 22072789]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3670	Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p; GO_component: GO:0005950 - anthranilate synthase complex [Evidence IPI] [PMID 3881257]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IEA]; GO_function: GO:0004049 - anthranilate synthase activity [Evidence IGI] [PMID 3881257]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0004425 - indole-3-glycerol-phosphate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004425 - indole-3-glycerol-phosphate synthase activity [Evidence IMP] [PMID 3881257]; GO_function: GO:0004425 - indole-3-glycerol-phosphate synthase activity [Evidence IGI,ISS] [PMID 6323449]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0000162 - tryptophan biosynthetic process [Evidence IMP] [PMID 10790693]; GO_process: GO:0006568 - tryptophan metabolic process [Evidence IEA]
AWJ20_3672	UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9560251]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004581 - dolichyl-phosphate beta-glucosyltransferase activity [Evidence IEA]; GO_function: GO:0004581 - dolichyl-phosphate beta-glucosyltransferase activity [Evidence IDA] [PMID 8076653]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence TAS] [PMID 8076653]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_3673	Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 22553352]; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA,IMP] [PMID 15657391]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 8314848]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,IMP] [PMID 11514624]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IMP] [PMID 11792713]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,IMP] [PMID 15657391]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 8314848]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IMP] [PMID 22452743]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0043812 - phosphatidylinositol-4-phosphate phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA,IGI,IMP] [PMID 10625610]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 22553352]
AWJ20_3675	Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008892 - guanine deaminase activity [Evidence IEA,IEA]; GO_function: GO:0008892 - guanine deaminase activity [Evidence IDA] [PMID 15565584]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence ISS] [PMID 10542258]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006147 - guanine catabolic process [Evidence IEA,IEA]; GO_process: GO:0046098 - guanine metabolic process [Evidence ISS] [PMID 10542258]
AWJ20_3676	6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 11298766]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0004616 - phosphogluconate dehydrogenase (decarboxylating) activity [Evidence IEA,IEA]; GO_function: GO:0004616 - phosphogluconate dehydrogenase (decarboxylating) activity [Evidence IMP] [PMID 1328471]; GO_process: GO:0019521 - D-gluconate metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA,IEA,IEA]; GO_process: GO:0009051 - pentose-phosphate shunt, oxidative branch [Evidence IGI,IMP] [PMID 1328471]
AWJ20_3677	Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12970194]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA,IEA]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IDA] [PMID 17401378]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence TAS] [PMID 12970194]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA,IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12970194]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IDA] [PMID 17401378]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_3679	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10788474]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005462 - UDP-N-acetylglucosamine transmembrane transporter activity [Evidence IMP] [PMID 10788474]; GO_function: GO:0005338 - nucleotide-sugar transmembrane transporter activity [Evidence IEA]; GO_process: GO:0015788 - UDP-N-acetylglucosamine transport [Evidence IMP] [PMID 10788474]; GO_process: GO:0015786 - UDP-glucose transport [Evidence IGI,IMP] [PMID 18693752]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IMP] [PMID 10788474]; GO_process: GO:1901679 - nucleotide transmembrane transport [Evidence IEA]; GO_process: GO:0015780 - nucleotide-sugar transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 10788474]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3681	Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16314178]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IMP] [PMID 16275642]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0000747 - conjugation with cellular fusion [Evidence IMP] [PMID 10628851]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10628851]; GO_process: GO:0061188 - negative regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 16286008]; GO_process: GO:0061186 - negative regulation of chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16314178]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 19372273]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16275642]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
AWJ20_3682	Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress; GO_component: GO:0035361 - Cul8-RING ubiquitin ligase complex [Evidence IDA] [PMID 20139071]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 14988729]; GO_process: GO:0010526 - negative regulation of transposition, RNA-mediated [Evidence IMP] [PMID 11779788]
AWJ20_3683	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_3684	eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IPI] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 11302750]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0002188 - translation reinitiation [Evidence IMP] [PMID 20679478]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]
AWJ20_3687	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 11591390]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IC,IPI] [PMID 11591390]
AWJ20_3689	RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2, U5, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0071014 - post-mRNA release spliceosomal complex [Evidence IMP] [PMID 11886864]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 11886864]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 17875666]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16382143]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16382143]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IGI] [PMID 19801658]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16382143]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 16227579]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 16382144]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 16382143]; GO_process: GO:0000390 - spliceosomal complex disassembly [Evidence IDA] [PMID 16357217]; GO_process: GO:0000390 - spliceosomal complex disassembly [Evidence IGI] [PMID 17875666]
AWJ20_3691	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_3692	Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA,IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 12045225]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IGI,IMP] [PMID 18694928]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IDA] [PMID 23919454]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006037 - cell wall chitin metabolic process [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0071555 - cell wall organization [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 18694928]
AWJ20_3707	Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 3036836]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016679 - oxidoreductase activity, acting on diphenols and related substances as donors [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IEA,IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 3036836]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IDA] [PMID 3036836]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3711	Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 1869583]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8144572]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 1869583]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 1400408]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 15342786]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9774392]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 10567418]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 15342786]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9674429]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1473150]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IMP] [PMID 1729605]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3713	Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21944719]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21987634]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 22009199]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0044284 - mitochondrial crista junction [Evidence IDA] [PMID 22009199]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21987634]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 22009199]
AWJ20_3714	Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9726978]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11120744]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IGI] [PMID 11120744]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,IMP] [PMID 10341420]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,IMP] [PMID 9726978]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015891 - siderophore transport [Evidence IMP] [PMID 9726978]
AWJ20_3720	Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15710404]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 9614122]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0034707 - chloride channel complex [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17662057]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15710404]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17662057]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17662057]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0005254 - chloride channel activity [Evidence IEA]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IDA] [PMID 12074596]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9614122]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:1902476 - chloride transmembrane transport [Evidence IEA]; GO_process: GO:0006821 - chloride transport [Evidence IEA,IEA]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0044070 - regulation of anion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3722	Protein required for full activation of the general stress response; required with binding partner Psr1p, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0019211 - phosphatase activator activity [Evidence IMP] [PMID 12090248]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 15020461]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 15020461]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 21429936]; GO_process: GO:0040008 - regulation of growth [Evidence IMP] [PMID 2204680]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 12090248]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 12090248]
AWJ20_3723	O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 10419476]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10419476]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10760477]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008425 - 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Evidence IEA]; GO_function: GO:0061543 - 3-demethylubiquinone-6 3-O-methyltransferase activity [Evidence IMP] [PMID 10419476]; GO_function: GO:0008689 - 3-demethylubiquinone-9 3-O-methyltransferase activity [Evidence IEA]; GO_function: GO:0004395 - hexaprenyldihydroxybenzoate methyltransferase activity [Evidence IEA]; GO_function: GO:0004395 - hexaprenyldihydroxybenzoate methyltransferase activity [Evidence IMP] [PMID 1885593]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IDA] [PMID 10419476]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 1885593]
AWJ20_3726	Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3727	Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 10037752]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 16034811]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 10037752]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 8991513]
AWJ20_3729	Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3730	Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; positive regulator of GCN4 expression; assembles into filaments with Gcd2p, Gcd6p, Gcd7p, and Sui2p as cells approach stationary phase and under cytosolic acidification and starvation conditions; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IMP] [PMID 8099443]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA] [PMID 8336705]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IPI] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP] [PMID 8099443]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI,IMP,IPI] [PMID 8887689]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP] [PMID 9032257]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 8506384]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 8099443]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 8336705]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 8099443]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IPI] [PMID 8887689]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 9032257]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_3731	RNA polymerase III subunit C37; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3732	Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under anaerobic conditions; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9582098]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 10322435]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9582098]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3735	Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage; GO_component: GO:0043505 - centromere-specific nucleosome [Evidence IDA] [PMID 22693454]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 21460225]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI] [PMID 19917722]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 16002464]; GO_process: GO:0043935 - sexual sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 20713519]
AWJ20_3736	Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0034729 - histone H3-K79 methylation [Evidence IMP] [PMID 18158898]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0043935 - sexual sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 20713519]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
AWJ20_3737	Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004751 - ribose-5-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004751 - ribose-5-phosphate isomerase activity [Evidence IMP,ISS] [PMID 8929392]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IGI] [PMID 8929392]; GO_process: GO:0009052 - pentose-phosphate shunt, non-oxidative branch [Evidence IEA]; GO_process: GO:0008615 - pyridoxine biosynthetic process [Evidence IMP] [PMID 14690456]
AWJ20_3738	Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex; GO_component: GO:0030121 - AP-1 adaptor complex [Evidence IPI,ISS] [PMID 10564262]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0016023 - cytoplasmic membrane-bounded vesicle [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IPI,ISS] [PMID 10564262]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 17003107]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IPI,ISS] [PMID 10564262]
AWJ20_3741	Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 9111353]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000964 - mitochondrial RNA 5'-end processing [Evidence IMP] [PMID 18086665]; GO_process: GO:0000964 - mitochondrial RNA 5'-end processing [Evidence IMP] [PMID 9111353]
AWJ20_3742	Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16850348]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 10869563]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 10869563]
AWJ20_3743	Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 22586276]; GO_component: GO:0000788 - nuclear nucleosome [Evidence IPI] [PMID 11574687]; GO_component: GO:0000786 - nucleosome [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9046096]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 11574687]; GO_process: GO:0030261 - chromosome condensation [Evidence IMP] [PMID 22586276]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IGI,IMP] [PMID 12820979]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IGI] [PMID 19017647]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 11574687]
AWJ20_3744	Putative transcription factor; has homolog in Kluyveromyces lactis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_3745	Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004401 - histidinol-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004401 - histidinol-phosphatase activity [Evidence IMP] [PMID 14190241]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]
AWJ20_3747	Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004827 - proline-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004827 - proline-tRNA ligase activity [Evidence IDA] [PMID 16864571]; GO_process: GO:0006433 - prolyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006433 - prolyl-tRNA aminoacylation [Evidence IDA] [PMID 16864571]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3748	Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IC] [PMID 9605503]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004816 - asparagine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004816 - asparagine-tRNA ligase activity [Evidence IDA,ISS] [PMID 9605503]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation [Evidence IDA,IGI,ISS] [PMID 9605503]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3749	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3751	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_3752	Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]
AWJ20_3754	Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 8982460]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0043008 - ATP-dependent protein binding [Evidence TAS] [PMID 8982460]; GO_function: GO:0031386 - protein tag [Evidence ISS] [PMID 3038523]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence TAS] [PMID 8982460]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016579 - protein deubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0006513 - protein monoubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0000209 - protein polyubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 8035826]
AWJ20_3755	Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004512 - inositol-3-phosphate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004512 - inositol-3-phosphate synthase activity [Evidence IMP] [PMID 7016881]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0006021 - inositol biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006021 - inositol biosynthetic process [Evidence IMP] [PMID 7016881]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
AWJ20_3757	Kinesin-related motor protein involved in mitotic spindle positioning; stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 9693366]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence TAS] [PMID 9153752]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007026 - negative regulation of microtubule depolymerization [Evidence IMP] [PMID 9693366]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 9693366]
AWJ20_3758	Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 9864365]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 9864365]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0003786 - actin lateral binding [Evidence TAS] [PMID 9153752]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IGI] [PMID 9864365]; GO_process: GO:0007015 - actin filament organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0008154 - actin polymerization or depolymerization [Evidence TAS] [PMID 10652251]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence TAS] [PMID 10652251]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence TAS] [PMID 10652251]; GO_process: GO:0030010 - establishment of cell polarity [Evidence TAS] [PMID 10652251]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence TAS] [PMID 10652251]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 10652251]; GO_process: GO:0000011 - vacuole inheritance [Evidence TAS] [PMID 10652251]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence TAS] [PMID 10652251]
AWJ20_3760	Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; ACC1 has a paralog, HFA1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9438137]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003989 - acetyl-CoA carboxylase activity [Evidence IEA,IEA]; GO_function: GO:0003989 - acetyl-CoA carboxylase activity [Evidence IMP,ISS] [PMID 8098706]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence ISS] [PMID 1350093]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IMP] [PMID 6108218]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0042759 - long-chain fatty acid biosynthetic process [Evidence IMP] [PMID 6103540]; GO_process: GO:2001295 - malonyl-CoA biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence TAS] [PMID 9442897]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12730220]
AWJ20_3762	Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3763	Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence ISS] [PMID 8100228]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IMP] [PMID 8100228]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IMP] [PMID 8100228]
AWJ20_3766	Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); SIS2 has a paralog, VHS3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC,IPI] [PMID 9636153]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7705654]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 9636153]; GO_component: GO:0071513 - phosphopantothenoylcysteine decarboxylase complex [Evidence IDA] [PMID 19915539]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence IDA,IMP] [PMID 19915539]; GO_function: GO:0004864 - protein phosphatase inhibitor activity [Evidence IEA]; GO_function: GO:0004864 - protein phosphatase inhibitor activity [Evidence IDA] [PMID 9636153]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 10592175]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IGI] [PMID 10022927]; GO_process: GO:0009651 - response to salt stress [Evidence IGI,IMP] [PMID 9636153]
AWJ20_3767	Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 8108735]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9853758]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IDA] [PMID 8108735]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0006875 - cellular metal ion homeostasis [Evidence IMP] [PMID 20429018]; GO_process: GO:0050849 - negative regulation of calcium-mediated signaling [Evidence IGI] [PMID 16455487]; GO_process: GO:0016242 - negative regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0045936 - negative regulation of phosphate metabolic process [Evidence IGI] [PMID 3915785]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 3915785]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 8108735]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 16455487]
AWJ20_3768	Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004306 - ethanolamine-phosphate cytidylyltransferase activity [Evidence IEA]; GO_function: GO:0004306 - ethanolamine-phosphate cytidylyltransferase activity [Evidence IDA,IMP,ISS] [PMID 8982874]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IMP] [PMID 8982874]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
AWJ20_3769	Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor; GO_component: GO:0045009 - chitosome [Evidence IDA] [PMID 8970154]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8970154]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA,IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IDA] [PMID 7952171]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 2523889]
AWJ20_3770	Fungal Genetics Stock Center 12543
AWJ20_3772	Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3773	Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA,IPI] [PMID 9343412]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA] [PMID 9343412]; GO_process: GO:0042149 - cellular response to glucose starvation [Evidence IMP] [PMID 9343412]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 9343412]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 9343412]; GO_process: GO:0071472 - cellular response to salt stress [Evidence IMP] [PMID 9343412]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3774	Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3775	Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 2142; belongs to Rossmann fold superfamily; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 23558746]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISM] [PMID 19351663]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence IMP] [PMID 23558746]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IEA,IEA]
AWJ20_3776	Vacuolar transporter; imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11274162]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11274162]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015186 - L-glutamine transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0015188 - L-isoleucine transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0005302 - L-tyrosine transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11274162]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 11274162]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP] [PMID 11274162]
AWJ20_3779	Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11853670]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22593205]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0030906 - retromer complex, inner shell [Evidence IPI] [PMID 22593205]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence TAS] [PMID 9714809]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 1473149]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0072665 - protein localization to vacuole [Evidence IMP] [PMID 22593205]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 7489715]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 22593205]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0000011 - vacuole inheritance [Evidence IDA] [PMID 7489715]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IDA] [PMID 9015302]
AWJ20_3780	Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16857587]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9711835]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19618123]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16857587]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19618123]; GO_function: GO:0016208 - AMP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003987 - acetate-CoA ligase activity [Evidence IEA,IEA]; GO_function: GO:0003987 - acetate-CoA ligase activity [Evidence IDA] [PMID 8910545]; GO_function: GO:0016880 - acid-ammonia (or amide) ligase activity [Evidence IDA] [PMID 18305111]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006085 - acetyl-CoA biosynthetic process [Evidence IDA] [PMID 8910545]; GO_process: GO:0019427 - acetyl-CoA biosynthetic process from acetate [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 16857587]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 19618123]
AWJ20_3782	Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein; GO_component: GO:0000110 - nucleotide-excision repair factor 1 complex [Evidence IPI] [PMID 8621533]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852079]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 1741062]; GO_function: GO:0000014 - single-stranded DNA endodeoxyribonuclease activity [Evidence IDA] [PMID 8253764]; GO_process: GO:0006277 - DNA amplification [Evidence IMP] [PMID 23271978]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 1741062]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000736 - double-strand break repair via single-strand annealing, removal of nonhomologous ends [Evidence IMP] [PMID 7891718]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 11514439]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 2188090]; GO_process: GO:0006296 - nucleotide-excision repair, DNA incision, 5'-to lesion [Evidence IDA] [PMID 7559571]; GO_process: GO:0000735 - removal of nonhomologous ends [Evidence IMP] [PMID 7891718]
AWJ20_3784	D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0097358 - D-leucyl-tRNA(Leu) deacylase activity [Evidence IMP] [PMID 10918062]; GO_function: GO:0051500 - D-tyrosyl-tRNA(Tyr) deacylase activity [Evidence IMP] [PMID 10766779]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_process: GO:0019478 - D-amino acid catabolic process [Evidence IEA]; GO_process: GO:1900832 - D-leucine catabolic process [Evidence IMP] [PMID 10918062]; GO_process: GO:1900829 - D-tyrosine catabolic process [Evidence IMP] [PMID 10918062]; GO_process: GO:0006399 - tRNA metabolic process [Evidence IMP] [PMID 10918062]
AWJ20_3788	Plasma membrane G protein coupled receptor (GPCR); interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10655215]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9388468]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9524122]; GO_function: GO:0004930 - G-protein coupled receptor activity [Evidence IEA]; GO_function: GO:0004930 - G-protein coupled receptor activity [Evidence IPI] [PMID 9388468]; GO_function: GO:0004930 - G-protein coupled receptor activity [Evidence IMP,IPI,ISS] [PMID 9524122]; GO_function: GO:0005536 - glucose binding [Evidence IMP] [PMID 15494315]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IPI] [PMID 9388468]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IMP,IPI] [PMID 9524122]; GO_process: GO:0051594 - detection of glucose [Evidence IMP] [PMID 15494315]; GO_process: GO:0009731 - detection of sucrose stimulus [Evidence IMP] [PMID 15494315]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IGI,IMP] [PMID 10361302]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IMP] [PMID 15494315]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IMP] [PMID 9813141]; GO_process: GO:0009757 - hexose mediated signaling [Evidence IMP] [PMID 10655215]; GO_process: GO:0009757 - hexose mediated signaling [Evidence IGI,IMP] [PMID 9813141]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12150916]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 10655215]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 15722108]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0009745 - sucrose mediated signaling [Evidence IMP] [PMID 15494315]
AWJ20_3789	Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISM] [PMID 19351663]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 21460220]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006479 - protein methylation [Evidence IDA] [PMID 21460220]
AWJ20_3790	Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003942 - N-acetyl-gamma-glutamyl-phosphate reductase activity [Evidence IEA]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004073 - aspartate-semialdehyde dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004073 - aspartate-semialdehyde dehydrogenase activity [Evidence IDA] [PMID 4145650]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_process: GO:0006531 - aspartate metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0009090 - homoserine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate [Evidence IEA,IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 4380684]
AWJ20_3791	Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IPI] [PMID 11711434]
AWJ20_3793	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IKR] [PMID 9032445]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IKR] [PMID 9032446]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity [Evidence IMP] [PMID 1322693]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence IEA]; GO_process: GO:0006000 - fructose metabolic process [Evidence IEA]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 1322693]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3798	GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 22575457]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 22575457]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23127800]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11914276]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 20162532]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23127800]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 6438624]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8106517]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0007190 - activation of adenylate cyclase activity [Evidence IDA] [PMID 8106517]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 2558958]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 2981630]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 3891097]; GO_process: GO:0000411 - positive regulation of transcription by galactose [Evidence IMP] [PMID 16292676]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 12782684]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 1547504]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 15917658]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 12839995]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 8034612]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_3799	Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9046086]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015893 - drug transport [Evidence IEP] [PMID 12697649]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3800	Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10531363]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10899126]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10899127]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11708797]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 14704159]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 10531363]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 10899126]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA,IMP] [PMID 15728580]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 9867817]; GO_process: GO:0080182 - histone H3-K4 trimethylation [Evidence IGI,IMP] [PMID 22778132]; GO_process: GO:0031064 - negative regulation of histone deacetylation [Evidence IMP,IPI] [PMID 10899127]; GO_process: GO:2000059 - negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 19597489]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 14704159]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IGI] [PMID 15166139]; GO_process: GO:2000749 - positive regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 10899127]; GO_process: GO:0035307 - positive regulation of protein dephosphorylation [Evidence IDA] [PMID 11904169]; GO_process: GO:0035307 - positive regulation of protein dephosphorylation [Evidence IMP] [PMID 19854134]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IPI] [PMID 10899126]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IDA,IMP] [PMID 15728580]; GO_process: GO:1901407 - regulation of phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 22778132]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 11708797]; GO_process: GO:0000117 - regulation of transcription involved in G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 11708797]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 14704159]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IGI,IMP] [PMID 19854134]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 22778132]
AWJ20_3807	Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication; GO_component: GO:0005955 - calcineurin complex [Evidence IPI] [PMID 10887154]; GO_component: GO:0005955 - calcineurin complex [Evidence IDA] [PMID 1321337]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004723 - calcium-dependent protein serine/threonine phosphatase activity [Evidence IDA] [PMID 1321337]; GO_function: GO:0005516 - calmodulin binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 1651503]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 8798496]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
AWJ20_3808	Protein with a potential role in pre-rRNA processing; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_3811	Chitin deacetylase; together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall; GO_component: GO:0005631 - chitosan layer of spore wall [Evidence ISS] [PMID 8940152]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004099 - chitin deacetylase activity [Evidence IEA]; GO_function: GO:0004099 - chitin deacetylase activity [Evidence IDA,ISS] [PMID 8940152]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA,IMP] [PMID 8940152]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3814	Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0012510 - trans-Golgi network transport vesicle membrane [Evidence IDA] [PMID 9325307]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IDA] [PMID 15078884]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IMP] [PMID 7708696]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IDA] [PMID 17961510]; GO_function: GO:0043682 - copper-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 7708696]; GO_process: GO:0060003 - copper ion export [Evidence IMP] [PMID 7708696]; GO_process: GO:0006825 - copper ion transport [Evidence IEA,IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 7708696]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3815	Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 3332961]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016868 - intramolecular transferase activity, phosphotransferases [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004619 - phosphoglycerate mutase activity [Evidence IEA]; GO_function: GO:0004619 - phosphoglycerate mutase activity [Evidence IDA] [PMID 1386023]; GO_function: GO:0004619 - phosphoglycerate mutase activity [Evidence IMP] [PMID 3033435]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 3033435]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 11015729]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3816	Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates unfolded protein response (UPR) by promoting the decay of HAC1 RNA; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 10747087]; GO_component: GO:0005795 - Golgi stack [Evidence IDA] [PMID 12802060]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IDA] [PMID 23129774]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10747087]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 20375281]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 20059749]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 3311726]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 9447979]; GO_function: GO:0000149 - SNARE binding [Evidence IDA,IPI] [PMID 18388317]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 15689495]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20375281]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 15689495]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 2504726]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 7593181]; GO_process: GO:0048194 - Golgi vesicle budding [Evidence IGI] [PMID 18388317]; GO_process: GO:0048211 - Golgi vesicle docking [Evidence IMP] [PMID 9545229]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IMP] [PMID 9157884]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 20059749]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 20059749]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20375281]; GO_process: GO:1990261 - pre-mRNA catabolic process [Evidence IMP] [PMID 22844259]; GO_process: GO:0006461 - protein complex assembly [Evidence IDA] [PMID 8603910]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 22844259]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IGI,IMP] [PMID 18388317]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_3817	Pumilio-homology domain protein; binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; co-sediments with the 60S ribosomal subunit and is required for its biogenesis; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IDA] [PMID 19806183]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003730 - mRNA 3'-UTR binding [Evidence IDA] [PMID 15198983]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000900 - translation repressor activity, nucleic acid binding [Evidence IDA] [PMID 15198983]; GO_process: GO:0017148 - negative regulation of translation [Evidence IDA] [PMID 15198983]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3818	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IDA,IPI] [PMID 2832951]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 7828851]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 2832951]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 2832951]; GO_process: GO:0043457 - regulation of cellular respiration [Evidence IMP] [PMID 2182199]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3822	Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p; GO_component: GO:0071021 - U2-type post-spliceosomal complex [Evidence IDA] [PMID 12212850]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 8474454]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 8474454]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA,IEA]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IDA] [PMID 12212850]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IGI] [PMID 17626844]; GO_process: GO:0008380 - RNA splicing [Evidence IEA,IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IDA] [PMID 12212850]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 12403466]; GO_process: GO:0071048 - nuclear retention of unspliced pre-mRNA at the site of transcription [Evidence IGI,IMP] [PMID 14718167]
AWJ20_3823	Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress; GO_component: GO:0000151 - ubiquitin ligase complex [Evidence IDA] [PMID 10445024]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 12456005]; GO_function: GO:0051087 - chaperone binding [Evidence IDA] [PMID 16945921]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 16945921]; GO_process: GO:0019933 - cAMP-mediated signaling [Evidence IGI,IPI] [PMID 12456005]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051382 - kinetochore assembly [Evidence IDA] [PMID 10445024]; GO_process: GO:0006461 - protein complex assembly [Evidence IGI,ISS] [PMID 12456005]; GO_process: GO:0006461 - protein complex assembly [Evidence IDA] [PMID 15090617]; GO_process: GO:0016567 - protein ubiquitination [Evidence TAS] [PMID 12456005]; GO_process: GO:0051726 - regulation of cell cycle [Evidence TAS] [PMID 11847307]
AWJ20_3824	Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12588997]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12502737]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12588997]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 12588997]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 19801658]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0070181 - small ribosomal subunit rRNA binding [Evidence IDA] [PMID 19706509]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IDA] [PMID 19801658]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEP,IMP] [PMID 12588997]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15388878]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP,IPI] [PMID 12502737]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IDA] [PMID 12588997]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IPI] [PMID 12628929]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3825	GTP-binding protein of the Ras superfamily; required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15282802]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8723349]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 1910037]; GO_function: GO:0003924 - GTPase activity [Evidence TAS] [PMID 9759491]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence TAS] [PMID 9891811]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence TAS] [PMID 2065354]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence TAS] [PMID 2690082]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 2065354]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 2690082]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence TAS] [PMID 9759491]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence TAS] [PMID 9891811]
AWJ20_3827	Fungal Genetics Stock Center 12071
AWJ20_3828	Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH2 has a paralog, SWH1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11408574]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 20008566]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12727870]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11408574]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20008566]; GO_function: GO:0008142 - oxysterol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0015248 - sterol transporter activity [Evidence IDA] [PMID 20008566]; GO_process: GO:0035621 - ER to Golgi ceramide transport [Evidence IMP] [PMID 24213531]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 15173322]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17004323]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IGI] [PMID 17004323]; GO_process: GO:0015918 - sterol transport [Evidence IGI] [PMID 16585271]; GO_process: GO:0015918 - sterol transport [Evidence IDA] [PMID 20008566]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3829	Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease; MEP3 has a paralog, MEP1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence TAS] [PMID 11486013]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 9234685]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IEA]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IDA,IMP,ISS] [PMID 9234685]; GO_process: GO:0072488 - ammonium transmembrane transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEA,IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IMP,ISS] [PMID 9234685]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 9234685]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3831	Mitochondrial leucyl-tRNA synthetase; also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1990003]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004823 - leucine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004823 - leucine-tRNA ligase activity [Evidence IDA] [PMID 1990003]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 11142386]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0000372 - Group I intron splicing [Evidence IMP] [PMID 12486008]; GO_process: GO:0000372 - Group I intron splicing [Evidence IMP] [PMID 2277640]; GO_process: GO:0006429 - leucyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006429 - leucyl-tRNA aminoacylation [Evidence IDA] [PMID 1990003]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI] [PMID 16777356]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3832	Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 22210050]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20826459]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 20709757]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 22210050]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 9694857]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 22210050]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015386 - potassium:proton antiporter activity [Evidence IMP] [PMID 15635088]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IEA]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IMP] [PMID 10998367]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IMP] [PMID 15635088]; GO_function: GO:0015299 - solute:proton antiporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0030004 - cellular monovalent inorganic cation homeostasis [Evidence IMP] [PMID 10589731]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0071805 - potassium ion transmembrane transport [Evidence IMP] [PMID 15635088]; GO_process: GO:0006813 - potassium ion transport [Evidence IEA]; GO_process: GO:0006885 - regulation of pH [Evidence IEA]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IMP] [PMID 10998367]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IMP] [PMID 15635088]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA,IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 10589731]
AWJ20_3833	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IEA]; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IDA] [PMID 15738391]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11927594]; GO_component: GO:0035861 - site of double-strand break [Evidence IDA] [PMID 16892052]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IDA] [PMID 15738391]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 16793545]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 11927594]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15738391]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0051304 - chromosome separation [Evidence IMP] [PMID 15793567]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IEA]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 16892052]; GO_process: GO:0071139 - resolution of recombination intermediates [Evidence IMP] [PMID 20159973]
AWJ20_3834	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IEA]; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IDA] [PMID 15738391]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11927594]; GO_component: GO:0035861 - site of double-strand break [Evidence IDA] [PMID 16892052]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IDA] [PMID 15738391]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 16793545]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 11927594]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15738391]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0051304 - chromosome separation [Evidence IMP] [PMID 15793567]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IEA]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 16892052]; GO_process: GO:0071139 - resolution of recombination intermediates [Evidence IMP] [PMID 20159973]
AWJ20_3835	Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IDA] [PMID 17192843]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA,IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 17192843]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8603910]; GO_process: GO:0048211 - Golgi vesicle docking [Evidence IDA] [PMID 9545229]; GO_process: GO:0048193 - Golgi vesicle transport [Evidence IEA]; GO_process: GO:0035493 - SNARE complex assembly [Evidence IMP] [PMID 8603910]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IEA]
AWJ20_3836	Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IDA] [PMID 17192843]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA,IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 17192843]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8603910]; GO_process: GO:0048211 - Golgi vesicle docking [Evidence IDA] [PMID 9545229]; GO_process: GO:0048193 - Golgi vesicle transport [Evidence IEA]; GO_process: GO:0035493 - SNARE complex assembly [Evidence IMP] [PMID 8603910]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IEA]
AWJ20_3838	Component of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 17652137]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17652137]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17652137]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 17652137]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 17652137]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3840	Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication; GO_component: GO:0097268 - cytoophidium [Evidence IDA] [PMID 20713603]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003883 - CTP synthase activity [Evidence IEA,IEA]; GO_function: GO:0003883 - CTP synthase activity [Evidence IMP,ISS] [PMID 1753946]; GO_function: GO:0003883 - CTP synthase activity [Evidence IDA] [PMID 8075080]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0044210 - 'de novo' CTP biosynthetic process [Evidence IEA]; GO_process: GO:0006241 - CTP biosynthetic process [Evidence IDA] [PMID 8075080]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 9668079]; GO_process: GO:0019856 - pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 1753946]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA,IEA]
AWJ20_3842	NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 19016485]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA,IMP] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3843	Cytoplasmic protein required for sporulation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3845	F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346238]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346239]; GO_component: GO:0043224 - nuclear SCF ubiquitin ligase complex [Evidence IDA] [PMID 11080155]; GO_component: GO:0016363 - nuclear matrix [Evidence IDA] [PMID 2244914]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11080155]; GO_function: GO:0050815 - phosphoserine binding [Evidence IDA] [PMID 23314252]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_function: GO:0061630 - ubiquitin protein ligase activity [Evidence IDA] [PMID 9346238]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 9346239]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10409741]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 10409741]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 7954792]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 328339]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3847	Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 21673967]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 21673659]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 21673967]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 21673659]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 21673659]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 21673967]; GO_process: GO:0019722 - calcium-mediated signaling [Evidence IMP] [PMID 21673967]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 21673967]
AWJ20_3851	Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18812321]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004590 - orotidine-5'-phosphate decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004590 - orotidine-5'-phosphate decarboxylase activity [Evidence IDA] [PMID 2061334]; GO_function: GO:0004590 - orotidine-5'-phosphate decarboxylase activity [Evidence IMP] [PMID 4550660]; GO_function: GO:0004590 - orotidine-5'-phosphate decarboxylase activity [Evidence IMP] [PMID 5651325]; GO_process: GO:0044205 - 'de novo' UMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 5651325]; GO_process: GO:0006222 - UMP biosynthetic process [Evidence IDA] [PMID 2061334]; GO_process: GO:0006222 - UMP biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0006222 - UMP biosynthetic process [Evidence IMP] [PMID 5651325]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA]
AWJ20_3852	RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9032262]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22083961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 18975973]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000464 - endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9032262]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3853	Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9659914]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016671 - oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IMP] [PMID 10982384]; GO_function: GO:0016972 - thiol oxidase activity [Evidence IDA] [PMID 16407158]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IGI] [PMID 11584268]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 9659913]
AWJ20_3854	Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores; GO_component: GO:0005619 - ascospore wall [Evidence IDA] [PMID 19779569]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 19779569]; GO_component: GO:0031160 - spore wall [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042802 - identical protein binding [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IBA,IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence ISS] [PMID 10592175]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 19779569]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IBA,IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_3855	Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15150670]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 21129186]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15150670]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 16380387]; GO_function: GO:0019211 - phosphatase activator activity [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IMP] [PMID 12952889]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15150670]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 9705277]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IPI] [PMID 11134337]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IMP] [PMID 11262194]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA]; GO_process: GO:0043618 - regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP,IPI] [PMID 21129186]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 10660069]
AWJ20_3856	Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0044611 - nuclear pore inner ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0044615 - nuclear pore nuclear basket [Evidence IDA] [PMID 10428845]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 10428845]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006999 - nuclear pore organization [Evidence IMP] [PMID 10428845]; GO_process: GO:0006999 - nuclear pore organization [Evidence IMP] [PMID 11121302]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 10684247]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3858	P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm; GO_component: GO:0005960 - glycine cleavage complex [Evidence ISS] [PMID 8830251]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IEA,IEA]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IDA] [PMID 320197]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IDA] [PMID 8830251]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IEA]; GO_process: GO:0019464 - glycine decarboxylation via glycine cleavage system [Evidence IEP,IMP] [PMID 8830251]; GO_process: GO:0006544 - glycine metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI] [PMID 10871621]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3859	2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11927565]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IDA] [PMID 11927565]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IMP,ISS] [PMID 9917067]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 11927565]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 11927565]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_3860	Lysyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 330225]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IDA] [PMID 3888626]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IMP] [PMID 7628447]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IDA] [PMID 3888626]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IMP] [PMID 7628447]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3861	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IEA]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 12242279]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 7995524]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IDA] [PMID 14749386]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IC] [PMID 7995524]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 7995524]; GO_process: GO:0001111 - promoter clearance from RNA polymerase II promoter [Evidence IC] [PMID 7995524]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 18362165]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 18362165]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IMP] [PMID 15572698]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IMP] [PMID 20033062]
AWJ20_3865	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 3967297]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 6365930]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 8163554]; GO_component: GO:0005884 - actin filament [Evidence IDA] [PMID 6217414]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 3967297]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 6365930]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 8163554]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 3967297]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 8163554]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 10911987]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IDA] [PMID 6217414]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IDA,IMP] [PMID 9732290]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA] [PMID 17118118]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence TAS] [PMID 10652251]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17287397]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 15024029]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI] [PMID 9864365]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence TAS] [PMID 10652251]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10911987]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 10652251]; GO_process: GO:0009306 - protein secretion [Evidence IGI,IMP] [PMID 10793147]; GO_process: GO:0000011 - vacuole inheritance [Evidence IGI,IMP] [PMID 8978821]; GO_process: GO:0030050 - vesicle transport along actin filament [Evidence TAS] [PMID 10652251]
AWJ20_3866	eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 9722586]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA,IPI,ISS] [PMID 7876188]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IEA]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 3029094]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]
AWJ20_3867	Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0003938 - IMP dehydrogenase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003938 - IMP dehydrogenase activity [Evidence ISS] [PMID 11003640]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006177 - GMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA]
AWJ20_3868	Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0003938 - IMP dehydrogenase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003938 - IMP dehydrogenase activity [Evidence ISS] [PMID 11003640]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006177 - GMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA]
AWJ20_3875	Mitochondrial intermembrane space hypothetical protein; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 11791739]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22993211]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11791739]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9874242]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_3876	Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 12127071]; GO_function: GO:0004864 - protein phosphatase inhibitor activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 7565759]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence TAS] [PMID 9584086]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0043666 - regulation of phosphoprotein phosphatase activity [Evidence IEA]; GO_process: GO:0009966 - regulation of signal transduction [Evidence IEA]
AWJ20_3877	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005874 - microtubule [Evidence IEA,IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0043234 - protein complex [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_component: GO:0045298 - tubulin complex [Evidence IDA,IPI] [PMID 9488492]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0045143 - homologous chromosome segregation [Evidence IC] [PMID 9488492]; GO_process: GO:0007017 - microtubule-based process [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IC] [PMID 9488492]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IC] [PMID 9488492]; GO_process: GO:0051258 - protein polymerization [Evidence IEA]; GO_process: GO:0046677 - response to antibiotic [Evidence IEA]
AWJ20_3878	Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8866476]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11390404]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015093 - ferrous iron transmembrane transporter activity [Evidence IMP] [PMID 11390404]; GO_function: GO:0005384 - manganese ion transmembrane transporter activity [Evidence IMP] [PMID 11390404]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI,IMP] [PMID 7941738]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IGI,IMP] [PMID 10713071]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IGI,IMP] [PMID 8866476]; GO_process: GO:0015684 - ferrous iron transport [Evidence IMP] [PMID 11390404]; GO_process: GO:0006828 - manganese ion transport [Evidence IMP] [PMID 11390404]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3880	High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 8893857]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000102 - L-methionine secondary active transmembrane transporter activity [Evidence IDA] [PMID 8893857]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0042883 - cysteine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0044690 - methionine import [Evidence IGI,IMP] [PMID 8893857]; GO_process: GO:0015821 - methionine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0000101 - sulfur amino acid transport [Evidence IMP] [PMID 8893857]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3882	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 3967297]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 6365930]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 8163554]; GO_component: GO:0005884 - actin filament [Evidence IDA] [PMID 6217414]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 3967297]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 6365930]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 8163554]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 3967297]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 8163554]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 10911987]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IDA] [PMID 6217414]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IDA,IMP] [PMID 9732290]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA] [PMID 17118118]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence TAS] [PMID 10652251]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17287397]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 15024029]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI] [PMID 9864365]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence TAS] [PMID 10652251]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10911987]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 10652251]; GO_process: GO:0009306 - protein secretion [Evidence IGI,IMP] [PMID 10793147]; GO_process: GO:0000011 - vacuole inheritance [Evidence IGI,IMP] [PMID 8978821]; GO_process: GO:0030050 - vesicle transport along actin filament [Evidence TAS] [PMID 10652251]
AWJ20_3884	Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 24124599]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 7507493]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IEA,IEA]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IMP] [PMID 10431803]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IGI] [PMID 7507493]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IMP] [PMID 15280017]; GO_process: GO:0006816 - calcium ion transport [Evidence IMP] [PMID 7507493]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 7507493]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 7507493]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3887	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; YPS1 has a paralog, MKC7, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA] [PMID 8389368]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0016485 - protein processing [Evidence IDA] [PMID 8626758]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_3889	Putative dihydrokaempferol 4-reductase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence ISA] [PMID 19577617]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_3890	E2-like enzyme; involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11149920]; GO_function: GO:0019776 - Atg8 ligase activity [Evidence IMP,ISS] [PMID 11100732]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11100732]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IDA,IMP] [PMID 15277523]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 9023185]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 11149920]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3891	Protein involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 11062262]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0000798 - nuclear cohesin complex [Evidence IDA] [PMID 22901742]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 22912589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005198 - structural molecule activity [Evidence ISS] [PMID 11137006]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 11448778]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 19736318]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 15819623]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 11062262]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 11062262]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 14623866]; GO_process: GO:0007129 - synapsis [Evidence IMP] [PMID 19736318]
AWJ20_3892	Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p; GO_component: GO:0032221 - Rpd3S complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0032221 - Rpd3S complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0000118 - histone deacetylase complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16286007]; GO_process: GO:0060195 - negative regulation of antisense RNA transcription [Evidence IMP] [PMID 21248844]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 19417103]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 19948887]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
AWJ20_3893	Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IGI,ISA] [PMID 8618900]; GO_function: GO:0008235 - metalloexopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0070084 - protein initiator methionine removal [Evidence IEA]; GO_process: GO:0035551 - protein initiator methionine removal involved in protein maturation [Evidence IMP] [PMID 11811952]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_3894	Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 205532]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004042 - acetyl-CoA:L-glutamate N-acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004042 - acetyl-CoA:L-glutamate N-acetyltransferase activity [Evidence IDA,IGI] [PMID 9428669]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004358 - glutamate N-acetyltransferase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004358 - glutamate N-acetyltransferase activity [Evidence IDA] [PMID 9428669]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA,IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence TAS] [PMID 12603335]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006592 - ornithine biosynthetic process [Evidence IDA] [PMID 9428669]
AWJ20_3897	RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IMP,ISS] [PMID 14730029]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 17332014]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 17631273]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 11720284]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 14730029]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 14730029]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
AWJ20_3899	Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 1400574]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IDA] [PMID 3882418]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence ISS] [PMID 2651436]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence ISS] [PMID 2689224]
AWJ20_3900	Putative paralog of ATR1; but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3901	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0015124 - allantoate transmembrane transporter activity [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IMP] [PMID 16429164]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IGI,IMP] [PMID 17693598]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015719 - allantoate transport [Evidence IMP] [PMID 3275614]; GO_process: GO:0042938 - dipeptide transport [Evidence IMP] [PMID 16429164]; GO_process: GO:0042938 - dipeptide transport [Evidence IGI,IMP] [PMID 17693598]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IMP] [PMID 16429164]
AWJ20_3902	Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; binds to mRNAs under glucose starvation, most often in the 3' UTR; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress; phosphorylation by PKA inhibits P body foci formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23706738]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA,IMP] [PMID 12730603]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23222640]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 10779343]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23706738]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 23706738]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IDA] [PMID 23222640]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IGI,IMP] [PMID 18981231]; GO_process: GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA [Evidence IMP,IPI] [PMID 10913177]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IMP] [PMID 20832728]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0045947 - negative regulation of translational initiation [Evidence IDA,IMP] [PMID 20832728]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IMP] [PMID 10779343]
AWJ20_3903	Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0000036 - ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process [Evidence ISS] [PMID 8394042]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0009107 - lipoate biosynthetic process [Evidence IMP] [PMID 9187370]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_3904	Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 8841414]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8841414]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0050203 - oxalate-CoA ligase activity [Evidence IDA,IMP] [PMID 24291261]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0033611 - oxalate catabolic process [Evidence IDA,IMP] [PMID 24291261]
AWJ20_3905	Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9528757]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 15126390]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17145778]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 10322435]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9528757]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9528757]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3906	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_3907	polyprotein of non-LTR retrotransposon Zorro 1 and repeat region-related DNA
AWJ20_3910	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 22331846]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 8565072]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 8816998]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 8565072]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 8816998]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA] [PMID 15817685]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12730220]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11071906]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3913	Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 10487762]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0032777 - Piccolo NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 12782659]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10911987]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence IDA] [PMID 10911987]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0010485 - H4 histone acetyltransferase activity [Evidence IDA] [PMID 12110674]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 10487762]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 17274630]; GO_function: GO:0034212 - peptide N-acetyltransferase activity [Evidence IMP] [PMID 23050233]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 12353039]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006354 - DNA-templated transcription, elongation [Evidence IDA,IMP] [PMID 15949446]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IGI,IMP] [PMID 16436512]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10082517]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10487762]; GO_process: GO:0018394 - peptidyl-lysine acetylation [Evidence IMP] [PMID 23050233]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 22539722]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 19822662]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 10082517]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 11867538]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11036083]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3914	Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IDA] [PMID 17550305]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 16380387]; GO_function: GO:0019211 - phosphatase activator activity [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IGI,ISS] [PMID 10660069]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IMP] [PMID 12952889]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IMP] [PMID 11262194]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IGI,IMP] [PMID 10660069]
AWJ20_3915	Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress; GO_component: GO:0043541 - UDP-N-acetylglucosamine transferase complex [Evidence IPI] [PMID 16100110]; GO_component: GO:0043541 - UDP-N-acetylglucosamine transferase complex [Evidence IPI] [PMID 16100113]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16100110]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16100113]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0042406 - extrinsic component of endoplasmic reticulum membrane [Evidence IDA] [PMID 16100110]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0004577 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [Evidence IEA]; GO_function: GO:0004577 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [Evidence IMP,ISS] [PMID 15615718]; GO_function: GO:0004577 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [Evidence IDA,IMP,ISS] [PMID 16100113]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006488 - dolichol-linked oligosaccharide biosynthetic process [Evidence IMP,ISS] [PMID 15615718]; GO_process: GO:0006488 - dolichol-linked oligosaccharide biosynthetic process [Evidence IDA,IMP,ISS] [PMID 16100113]; GO_process: GO:0030259 - lipid glycosylation [Evidence IEA]
AWJ20_3916	Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 10805735]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005506 - iron ion binding [Evidence IDA] [PMID 21987576]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IGI,IMP] [PMID 17259550]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IGI,IMP] [PMID 10805735]
AWJ20_3919	Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IEA]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IDA] [PMID 19342587]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0008793 - aromatic-amino-acid:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0008793 - aromatic-amino-acid:2-oxoglutarate aminotransferase activity [Evidence IDA] [PMID 9491082]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0009094 - L-phenylalanine biosynthetic process [Evidence IEA]; GO_process: GO:0009072 - aromatic amino acid family metabolic process [Evidence IGI,IMP] [PMID 9491083]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0006571 - tyrosine biosynthetic process [Evidence IEA]
AWJ20_3921	ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15077113]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15077114]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 9920936]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,ISS] [PMID 9920936]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 16926193]; GO_process: GO:0006886 - intracellular protein transport [Evidence IMP] [PMID 9920936]; GO_process: GO:0033365 - protein localization to organelle [Evidence IMP] [PMID 12620189]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3922	N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Evidence IEA,IEA]; GO_function: GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Evidence IDA] [PMID 1756975]; GO_function: GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Evidence IMP] [PMID 5767024]; GO_function: GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Evidence IMP] [PMID 5767025]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IDA] [PMID 1756975]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 5767024]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 5767025]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IDA] [PMID 1756975]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 5767024]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 5767025]
AWJ20_3923	Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 17166847]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 18180296]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0004741 - [pyruvate dehydrogenase (lipoamide)] phosphatase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 17002782]; GO_process: GO:0016236 - macroautophagy [Evidence IGI] [PMID 17166847]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 17166847]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IMP] [PMID 18180296]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 18180296]
AWJ20_3924	polyprotein of non-LTR retrotransposon Zorro 1 and repeat region-related DNA
AWJ20_3929	Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 24868093]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 18034159]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 18034159]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0034084 - steryl deacetylase activity [Evidence IDA,IMP] [PMID 18034159]; GO_process: GO:0009636 - response to toxic substance [Evidence IMP] [PMID 18034159]; GO_process: GO:0034210 - sterol deacetylation [Evidence IMP] [PMID 18034159]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 18034159]
AWJ20_3931	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS); GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12721307]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence ISA] [PMID 12721307]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016709 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 21944752]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9266513]
AWJ20_3934	Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19959834]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 9544243]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IMP] [PMID 19959834]
AWJ20_3935	Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IMP] [PMID 15256563]; GO_process: GO:0006068 - ethanol catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3938	Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; ORC1 has a paralog, SIR3, that arose from the whole genome duplication; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005664 - nuclear origin of replication recognition complex [Evidence IDA,IMP] [PMID 9372948]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11168584]; GO_component: GO:0000808 - origin recognition complex [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 17825064]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 9038340]; GO_function: GO:0016887 - ATPase activity [Evidence IMP] [PMID 9038340]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11168584]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 16716188]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 12897051]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA,IGI] [PMID 16581798]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 9335335]
AWJ20_3939	Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 1997207]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 7816798]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 1997207]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12869188]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2466847]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA,IMP] [PMID 10488334]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 2407740]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA,IMP] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA,IMP] [PMID 2215682]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA] [PMID 2407740]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 10848624]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 19129178]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 6754086]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IGI,IMP] [PMID 18753406]; GO_process: GO:0048194 - Golgi vesicle budding [Evidence IDA] [PMID 9553090]; GO_process: GO:0048194 - Golgi vesicle budding [Evidence IDA] [PMID 9736710]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 14528019]; GO_process: GO:2001246 - negative regulation of phosphatidylcholine biosynthetic process [Evidence IDA,IMP] [PMID 7816798]; GO_process: GO:1901352 - negative regulation of phosphatidylglycerol biosynthetic process [Evidence IMP] [PMID 12869188]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IGI,IMP] [PMID 10567405]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 10848624]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA,IMP] [PMID 2215682]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 2407740]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3940	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 22331846]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 21818277]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI] [PMID 15725626]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16418532]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 17538013]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 8565072]; GO_process: GO:0031990 - mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 18258809]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0035392 - maintenance of chromatin silencing at telomere [Evidence IMP] [PMID 16418532]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 8565072]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22110603]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA,IGI,IMP] [PMID 15817685]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12730220]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 16418532]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3942	Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 10967121]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 6088500]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IEA,IEA]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IMP] [PMID 2989818]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IDA] [PMID 6088500]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0031490 - chromatin DNA binding [Evidence IBA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 2549254]; GO_process: GO:0006265 - DNA topological change [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IMP] [PMID 2989818]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 6088500]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IMP] [PMID 9199287]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 10082585]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IGI,IMP] [PMID 8895658]; GO_process: GO:0007097 - nuclear migration [Evidence IGI,IMP] [PMID 8895658]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 2902925]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 1660829]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 2840207]
AWJ20_3943	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23509072]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 11522252]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005761 - mitochondrial ribosome [Evidence IDA] [PMID 21670217]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11522252]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043022 - ribosome binding [Evidence IDA,IPI] [PMID 21670217]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 11522252]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 15759116]; GO_process: GO:0070131 - positive regulation of mitochondrial translation [Evidence IMP] [PMID 21670217]
AWJ20_3944	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35; GO_component: GO:0072546 - ER membrane protein complex [Evidence IDA] [PMID 19325107]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 19325107]
AWJ20_3945	Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009968 - negative regulation of signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IMP,IPI] [PMID 11741537]
AWJ20_3947	Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IMP] [PMID 17173333]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence ISS] [PMID 9341119]; GO_process: GO:0009436 - glyoxylate catabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence ISS] [PMID 9341119]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_3949	expressed protein
AWJ20_3951	Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 15082763]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IGI,IMP,IPI] [PMID 9819425]; GO_process: GO:0045727 - positive regulation of translation [Evidence IMP,IPI] [PMID 15082763]; GO_process: GO:0034063 - stress granule assembly [Evidence IMP] [PMID 18981231]
AWJ20_3953	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 7958901]; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 8702872]; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 8887672]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22362748]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001164 - RNA polymerase I CORE element sequence-specific DNA binding [Evidence IDA] [PMID 18451108]; GO_function: GO:0001187 - RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity [Evidence IC]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA,IPI] [PMID 8702872]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006361 - transcription initiation from RNA polymerase I promoter [Evidence NAS] [PMID 7958901]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IDA,IMP] [PMID 7958901]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3954	Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8132557]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0004799 - thymidylate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004799 - thymidylate synthase activity [Evidence IMP] [PMID 334734]; GO_function: GO:0004799 - thymidylate synthase activity [Evidence IDA] [PMID 6287238]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006231 - dTMP biosynthetic process [Evidence IEA]; GO_process: GO:0006231 - dTMP biosynthetic process [Evidence IMP] [PMID 334734]; GO_process: GO:0006231 - dTMP biosynthetic process [Evidence IMP] [PMID 794696]; GO_process: GO:0006235 - dTTP biosynthetic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA]
AWJ20_3957	Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0008097 - 5S rRNA binding [Evidence IEA]; GO_function: GO:0008097 - 5S rRNA binding [Evidence IDA] [PMID 8764831]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 8474444]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3958	Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IEP,ISS] [PMID 14534306]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,ISS] [PMID 14534306]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]
AWJ20_3961	Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; GO_component: GO:0043564 - Ku70:Ku80 complex [Evidence IEA]; GO_component: GO:0043564 - Ku70:Ku80 complex [Evidence IDA] [PMID 8754818]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence TAS] [PMID 10367891]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 10638763]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence TAS] [PMID 12080091]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12975323]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence TAS] [PMID 10367891]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IDA] [PMID 11553718]; GO_process: GO:0006342 - chromatin silencing [Evidence IDA,IMP] [PMID 9501103]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI,IMP] [PMID 18791224]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IGI,IMP] [PMID 17321803]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 11016833]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IEA]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IMP] [PMID 10908335]; GO_process: GO:0097552 - mitochondrial double-strand break repair via homologous recombination [Evidence IMP] [PMID 22214610]; GO_process: GO:0000723 - telomere maintenance [Evidence IEA]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 10818099]
AWJ20_3964	Protein that recognizes and binds damaged DNA during NER; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein; NER stands for nucleotide excision repair; GO_component: GO:0000110 - nucleotide-excision repair factor 1 complex [Evidence IPI] [PMID 8621533]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852079]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 23925126]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 8516285]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 8516285]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0000715 - nucleotide-excision repair, DNA damage recognition [Evidence IDA] [PMID 8516285]
AWJ20_3965	Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005664 - nuclear origin of replication recognition complex [Evidence IDA,IMP] [PMID 9372948]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000808 - origin recognition complex [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 9038340]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 16716188]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 7579692]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 12897051]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16980387]
AWJ20_3966	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p); GO_component: GO:0033565 - ESCRT-0 complex [Evidence IPI] [PMID 12055639]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12055639]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 9702203]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 12055639]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 20150893]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 12055639]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12055639]
AWJ20_3967	Protein with positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18032584]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 18032584]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 18032584]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3968	Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 16790493]; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 16943180]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 16790493]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 16943180]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14690591]; GO_function: GO:0004605 - phosphatidate cytidylyltransferase activity [Evidence IDA,IMP] [PMID 23623749]; GO_process: GO:0032049 - cardiolipin biosynthetic process [Evidence IMP] [PMID 19114592]; GO_process: GO:0032049 - cardiolipin biosynthetic process [Evidence IGI] [PMID 20485265]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3970	Phosphoesterase; involved in downregulation of the unfolded protein response (UPR), at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IMP,ISS] [PMID 15590836]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA,IMP] [PMID 17673172]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IDA] [PMID 16990850]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IGI,IMP] [PMID 16990850]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 16990850]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA,IMP] [PMID 17673172]; GO_process: GO:0007089 - traversing start control point of mitotic cell cycle [Evidence IMP] [PMID 15590836]
AWJ20_3971	Putative PINc domain nuclease; required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16762320]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16769905]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA,IPI] [PMID 16769905]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_3973	Arginyl-tRNA synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog, MSR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004814 - arginine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004814 - arginine-tRNA ligase activity [Evidence IDA] [PMID 9622124]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006420 - arginyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006420 - arginyl-tRNA aminoacylation [Evidence IDA] [PMID 9622124]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3976	Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IMP] [PMID 3552672]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015175 - neutral amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IDA,IGI] [PMID 8455553]; GO_process: GO:0015804 - neutral amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0015824 - proline transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3977	Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA,IMP] [PMID 12925762]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000214 - tRNA-intron endonuclease complex [Evidence IEA]; GO_component: GO:0000214 - tRNA-intron endonuclease complex [Evidence IDA] [PMID 9200603]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000213 - tRNA-intron endonuclease activity [Evidence IEA]; GO_function: GO:0000213 - tRNA-intron endonuclease activity [Evidence IMP] [PMID 2182322]; GO_function: GO:0000213 - tRNA-intron endonuclease activity [Evidence IDA] [PMID 9200603]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IEA]; GO_process: GO:0000379 - tRNA-type intron splice site recognition and cleavage [Evidence IMP] [PMID 2182322]; GO_process: GO:0000379 - tRNA-type intron splice site recognition and cleavage [Evidence IDA] [PMID 9200603]
AWJ20_3982	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8016655]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA,IMP] [PMID 8159677]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0000228 - nuclear chromosome [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 2233708]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IPI] [PMID 11865042]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IMP,IPI] [PMID 14580348]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 14580348]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IMP] [PMID 1459453]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 16024655]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 1339306]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 1901413]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3542227]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0005987 - sucrose catabolic process [Evidence IMP] [PMID 6392017]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_3983	Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 3521891]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 3521891]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IDA] [PMID 16741232]; GO_function: GO:0004821 - histidine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006427 - histidyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006427 - histidyl-tRNA aminoacylation [Evidence IMP] [PMID 1459448]; GO_process: GO:0006427 - histidyl-tRNA aminoacylation [Evidence IDA] [PMID 16741232]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI] [PMID 16777356]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_3984	TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IDA] [PMID 1429681]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IDA] [PMID 7961670]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 11779853]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 8702741]; GO_function: GO:0001097 - TFIIH-class transcription factor binding [Evidence IDA] [PMID 8702741]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 9271406]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 1429681]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 7961670]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9188494]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9271406]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001113 - transcriptional open complex formation at RNA polymerase II promoter [Evidence IDA,IGI] [PMID 10973956]
AWJ20_3986	Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15252052]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033179 - proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0033177 - proton-transporting two-sector ATPase complex, proton-transporting domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence TAS] [PMID 12482875]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9434348]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9434348]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 2145283]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 2145283]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence TAS] [PMID 12482875]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 2145283]
AWJ20_3987	Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; GO_component: GO:0000974 - Prp19 complex [Evidence IPI] [PMID 12088152]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 12554883]
AWJ20_3988	Putative prenyltransferase; required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11086160]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14690591]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24390141]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 14690591]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008834 - di-trans,poly-cis-decaprenylcistransferase activity [Evidence IEA]; GO_function: GO:0004659 - prenyltransferase activity [Evidence ISS] [PMID 14690591]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 16943325]
AWJ20_3989	Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair; GO_component: GO:1990130 - Iml1 complex [Evidence IDA] [PMID 21900499]; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034198 - cellular response to amino acid starvation [Evidence IMP] [PMID 19521502]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 18069899]; GO_process: GO:0032007 - negative regulation of TOR signaling [Evidence IMP] [PMID 19521502]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]; GO_process: GO:2000785 - regulation of autophagic vacuole assembly [Evidence IMP] [PMID 21900499]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3990	Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10811607]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 1869573]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 10811607]
AWJ20_3992	ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence ISS] [PMID 10793139]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 12441642]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IMP] [PMID 10793139]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 10793139]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 12441642]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_3996	Integral membrane protein of the early Golgi apparatus and ER; involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 16957051]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 16107716]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 16957051]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0097020 - COPII adaptor activity [Evidence IMP,IPI] [PMID 20236934]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IDA,IMP] [PMID 16957051]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 16107716]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 16107716]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 16107716]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_3997	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IGI] [PMID 15280369]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IMP] [PMID 10212224]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IGI] [PMID 15280369]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 15470112]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009156 - ribonucleoside monophosphate biosynthetic process [Evidence IEA]
AWJ20_3998	Protein involved in ER-to-Golgi transport; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23613772]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 1903839]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_3999	Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18281282]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0034396 - negative regulation of transcription from RNA polymerase II promoter in response to iron [Evidence IGI,IMP] [PMID 18281282]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_4000	Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15951236]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_function: GO:0008398 - sterol 14-demethylase activity [Evidence IEA]; GO_function: GO:0008398 - sterol 14-demethylase activity [Evidence IDA] [PMID 9087488]; GO_process: GO:0070988 - demethylation [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_4001	Karyopherin beta; responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 10525531]; GO_process: GO:0006606 - protein import into nucleus [Evidence IDA,IMP] [PMID 10525531]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4002	Protein necessary for stability of L-A dsRNA-containing particles; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0044419 - interspecies interaction between organisms [Evidence IMP] [PMID 3551911]
AWJ20_4005	5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19699691]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19699691]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0008409 - 5'-3' exonuclease activity [Evidence IEA]; GO_function: GO:0008409 - 5'-3' exonuclease activity [Evidence IDA] [PMID 9166764]; GO_function: GO:0017108 - 5'-flap endonuclease activity [Evidence IEA]; GO_function: GO:0017108 - 5'-flap endonuclease activity [Evidence IDA] [PMID 11825897]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA,IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IEA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IDA] [PMID 16837458]; GO_process: GO:0006284 - base-excision repair [Evidence IEA]; GO_process: GO:0006286 - base-excision repair, base-free sugar-phosphate removal [Evidence IGI,IMP] [PMID 9927726]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA] [PMID 15342630]; GO_process: GO:0000734 - gene conversion at mating-type locus, DNA repair synthesis [Evidence IMP] [PMID 10025407]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IGI,IMP] [PMID 16079237]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA,IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 12024027]
AWJ20_4006	Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11238901]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7690756]; GO_function: GO:0017005 - 3'-tyrosyl-DNA phosphodiesterase activity [Evidence IDA] [PMID 12397185]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IDA] [PMID 12767225]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IMP,ISS] [PMID 1693433]; GO_function: GO:0008311 - double-stranded DNA 3'-5' exodeoxyribonuclease activity [Evidence IDA] [PMID 16024777]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IDA] [PMID 3056935]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IDA] [PMID 9295360]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
AWJ20_4009	NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 19016485]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA,IMP] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4013	Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9611201]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4017	Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10490648]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10805747]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0032174 - cellular bud neck septin collar [Evidence IDA] [PMID 23389636]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0008469 - histone-arginine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0035241 - protein-arginine omega-N monomethyltransferase activity [Evidence IDA] [PMID 16426232]; GO_function: GO:0035241 - protein-arginine omega-N monomethyltransferase activity [Evidence IDA] [PMID 18515076]; GO_function: GO:0035243 - protein-arginine omega-N symmetric methyltransferase activity [Evidence IDA] [PMID 18515076]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 10490630]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0044257 - cellular protein catabolic process [Evidence IMP] [PMID 23042131]; GO_process: GO:0034969 - histone arginine methylation [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0006479 - protein methylation [Evidence IEA]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 8647431]
AWJ20_4018	RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 8896463]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0008266 - poly(U) RNA binding [Evidence IDA] [PMID 16428605]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0000464 - endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4019	RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 8896463]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0008266 - poly(U) RNA binding [Evidence IDA] [PMID 16428605]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0000464 - endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4020	Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20799725]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016671 - oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Evidence IEA]; GO_function: GO:0008113 - peptide-methionine (S)-S-oxide reductase activity [Evidence IEA,IEA]; GO_function: GO:0008113 - peptide-methionine (S)-S-oxide reductase activity [Evidence IDA,IMP] [PMID 15141092]; GO_function: GO:0008113 - peptide-methionine (S)-S-oxide reductase activity [Evidence IDA,IMP,ISS] [PMID 9275166]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI,IMP] [PMID 11929995]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 9275166]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0030091 - protein repair [Evidence IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
AWJ20_4024	Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11311123]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9563516]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11311123]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9563516]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004396 - hexokinase activity [Evidence IEA,IEA]; GO_function: GO:0004396 - hexokinase activity [Evidence IDA] [PMID 12611889]; GO_function: GO:0004396 - hexokinase activity [Evidence IDA] [PMID 332086]; GO_function: GO:0004396 - hexokinase activity [Evidence IMP] [PMID 6341351]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0032445 - fructose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006000 - fructose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0046323 - glucose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IDA] [PMID 332086]; GO_process: GO:0006096 - glycolytic process [Evidence IDA,IMP] [PMID 8917466]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEA]; GO_process: GO:0006013 - mannose metabolic process [Evidence IDA] [PMID 332086]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0046015 - regulation of transcription by glucose [Evidence IDA] [PMID 11311123]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 15722108]
AWJ20_4025	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4028	Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation; GO_component: GO:0070545 - PeBoW complex [Evidence IDA,IPI] [PMID 16287855]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IEA]; GO_process: GO:0044786 - cell cycle DNA replication [Evidence IMP] [PMID 12110181]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IDA] [PMID 11911362]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IDA] [PMID 16888624]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
AWJ20_4030	Intracellular sporulation-specific glucoamylase; involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 2493265]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004339 - glucan 1,4-alpha-glucosidase activity [Evidence IEA,IEA]; GO_function: GO:0004339 - glucan 1,4-alpha-glucosidase activity [Evidence IDA] [PMID 2493265]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP] [PMID 350852]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0005980 - glycogen catabolic process [Evidence IMP] [PMID 11486014]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]; GO_process: GO:0005976 - polysaccharide metabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_4032	Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12774122]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 12774122]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 20558178]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0010821 - regulation of mitochondrion organization [Evidence IMP] [PMID 11907266]; GO_process: GO:0010821 - regulation of mitochondrion organization [Evidence IMP] [PMID 12707284]; GO_process: GO:0006465 - signal peptide processing [Evidence IMP] [PMID 12417197]
AWJ20_4033	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4034	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4035	Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8396728]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 18191224]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 8396728]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18191224]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 8393731]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 8396728]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 8641272]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 8781238]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA,IMP] [PMID 8396728]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 19345192]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
AWJ20_4039	UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 14755638]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 14755638]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 14755638]
AWJ20_4040	Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2665820]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16850348]; GO_function: GO:0047433 - branched-chain-2-oxoacid decarboxylase activity [Evidence IMP] [PMID 9546164]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IEA]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IDA] [PMID 23423327]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IDA] [PMID 2404950]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IGI] [PMID 12499363]; GO_process: GO:0000955 - amino acid catabolic process via Ehrlich pathway [Evidence IEA]; GO_process: GO:0000949 - aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IDA] [PMID 2404950]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IDA] [PMID 2404950]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IGI] [PMID 12499363]
AWJ20_4041	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4042	Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4043	Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rholp guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10594031]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9819423]; GO_component: GO:0000922 - spindle pole [Evidence IDA] [PMID 10594031]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 16763112]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 12637549]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA,IMP] [PMID 17122856]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA,IMP] [PMID 8321244]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0010696 - positive regulation of spindle pole body separation [Evidence IGI,IMP] [PMID 18500339]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 16763112]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA,IMP] [PMID 17122856]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA,IMP] [PMID 8321244]; GO_process: GO:0000712 - resolution of meiotic recombination intermediates [Evidence IMP] [PMID 12717442]; GO_process: GO:0090306 - spindle assembly involved in meiosis [Evidence IMP] [PMID 20237423]; GO_process: GO:0070194 - synaptonemal complex disassembly [Evidence IGI] [PMID 18832066]
AWJ20_4046	Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16647879]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IMP] [PMID 16818716]; GO_function: GO:0019706 - protein-cysteine S-palmitoyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0018345 - protein palmitoylation [Evidence IMP] [PMID 16751107]; GO_process: GO:0018345 - protein palmitoylation [Evidence IMP] [PMID 16818716]
AWJ20_4047	Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_function: GO:0004056 - argininosuccinate lyase activity [Evidence IEA,IEA]; GO_function: GO:0004056 - argininosuccinate lyase activity [Evidence IDA] [PMID 4578972]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0042450 - arginine biosynthetic process via ornithine [Evidence IEA]; GO_process: GO:0042450 - arginine biosynthetic process via ornithine [Evidence IDA] [PMID 4578972]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]
AWJ20_4048	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4051	GTP-binding protein of the Ras superfamily; involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 19154724]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 12048186]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10688190]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence TAS] [PMID 16039591]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_4053	Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 18193418]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 18023287]; GO_function: GO:0004455 - ketol-acid reductoisomerase activity [Evidence IEA,IEA]; GO_function: GO:0004455 - ketol-acid reductoisomerase activity [Evidence IMP] [PMID 14124940]; GO_function: GO:0004455 - ketol-acid reductoisomerase activity [Evidence IMP] [PMID 3027658]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IMP] [PMID 14124940]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 18826960]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 7621838]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
AWJ20_4054	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4055	Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1; GO_component: GO:0070545 - PeBoW complex [Evidence IDA,IPI] [PMID 16287855]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11522832]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 16287855]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
AWJ20_4056	U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM); GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 15565172]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 16314500]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9436903]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 16314500]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP,IPI] [PMID 9436903]
AWJ20_4057	Protein involved in mating response; invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9742096]; GO_function: GO:0032093 - SAM domain binding [Evidence IDA] [PMID 16337230]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IDA,IPI] [PMID 10397774]; GO_process: GO:0000161 - MAPK cascade involved in osmosensory signaling pathway [Evidence IMP,IPI] [PMID 9742096]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0007050 - cell cycle arrest [Evidence IEA]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 12455951]; GO_process: GO:0007232 - osmosensory signaling pathway via Sho1 osmosensor [Evidence IMP] [PMID 11370856]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP,IPI] [PMID 8793874]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IMP,IPI] [PMID 9738877]
AWJ20_4060	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0004475 - mannose-1-phosphate guanylyltransferase activity [Evidence IEA]; GO_function: GO:0004475 - mannose-1-phosphate guanylyltransferase activity [Evidence IDA,IMP] [PMID 9195935]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IDA,IMP] [PMID 9195935]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 11055399]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9195935]
AWJ20_4061	Catalytic subunit of the i-AAA protease complex; complex is located in the mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as a nonconventional translocation motor to pull PNPase into the intermembrane space; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover; GO_component: GO:0031942 - i-AAA complex [Evidence IDA] [PMID 16267274]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 8688560]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 15772085]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IGI] [PMID 8688560]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 18843051]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 22993211]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IDA,IMP] [PMID 16966379]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 16966379]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_4063	Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10427036]; GO_function: GO:0018738 - S-formylglutathione hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0018738 - S-formylglutathione hydrolase activity [Evidence IDA] [PMID 10427036]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0046294 - formaldehyde catabolic process [Evidence IEA]; GO_process: GO:0046294 - formaldehyde catabolic process [Evidence IMP] [PMID 10427036]
AWJ20_4064	Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog, DMA1, that arose from the whole genome duplication; GO_component: GO:0032177 - cellular bud neck split septin rings [Evidence IMP] [PMID 23442799]; GO_component: GO:0005934 - cellular bud tip [Evidence IMP] [PMID 23442799]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 18202552]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0032186 - cellular bud neck septin ring organization [Evidence IGI] [PMID 22570619]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI] [PMID 15146058]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI] [PMID 22570619]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IGI] [PMID 15146058]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IGI] [PMID 22570619]; GO_process: GO:0051865 - protein autoubiquitination [Evidence IDA] [PMID 18202552]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 22570619]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 21562220]; GO_process: GO:0000921 - septin ring assembly [Evidence IGI] [PMID 15146058]; GO_process: GO:0000921 - septin ring assembly [Evidence IGI] [PMID 22570619]
AWJ20_4065	Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11846793]; GO_component: GO:0009514 - glyoxysome [Evidence IEA,IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 11846793]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 2211514]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004474 - malate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004474 - malate synthase activity [Evidence IMP] [PMID 23642236]; GO_function: GO:0004474 - malate synthase activity [Evidence IMP] [PMID 8878673]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IMP] [PMID 23642236]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IMP] [PMID 8878673]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
AWJ20_4066	P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 17430889]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4069	hypothetical protein; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4072	Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 17893149]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 7929594]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 21193403]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 21193403]; GO_component: GO:0030133 - transport vesicle [Evidence IDA] [PMID 21193403]; GO_function: GO:0015926 - glucosidase activity [Evidence IMP,ISS] [PMID 10601196]; GO_process: GO:0006078 - (1->6)-beta-D-glucan biosynthetic process [Evidence IMP,ISS] [PMID 7929594]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 7929594]
AWJ20_4073	Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10468587]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP,ISS] [PMID 10468587]; GO_process: GO:0006880 - intracellular sequestering of iron ion [Evidence IMP] [PMID 10588895]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 10468587]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 10588895]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12065597]
AWJ20_4074	Poly(A) binding protein; part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15630021]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15769879]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15630021]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15769879]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 8631901]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA,IMP] [PMID 9193001]; GO_function: GO:0008428 - ribonuclease inhibitor activity [Evidence IDA] [PMID 11889048]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IDA,IMP] [PMID 17766253]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA,IMP] [PMID 10357826]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4076	Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 22927826]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IMP] [PMID 7706223]
AWJ20_4077	Putative kinase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4080	Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_function: GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [Evidence IEA]; GO_function: GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [Evidence IDA,IMP] [PMID 10734185]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004112 - cyclic-nucleotide phosphodiesterase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0009187 - cyclic nucleotide metabolic process [Evidence IDA] [PMID 10734185]
AWJ20_4083	8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 10922370]; GO_function: GO:0008413 - 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [Evidence IDA,IMP] [PMID 15475388]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016462 - pyrophosphatase activity [Evidence IDA] [PMID 10922370]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15475388]; GO_process: GO:0009132 - nucleoside diphosphate metabolic process [Evidence IEA]
AWJ20_4085	Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex; GO_component: GO:0030121 - AP-1 adaptor complex [Evidence IPI,ISS] [PMID 10564262]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0016023 - cytoplasmic membrane-bounded vesicle [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IPI,ISS] [PMID 10564262]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 17003107]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IPI,ISS] [PMID 10564262]
AWJ20_4086	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4087	Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway; GO_component: GO:0009316 - 3-isopropylmalate dehydratase complex [Evidence IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 4355481]; GO_function: GO:0003861 - 3-isopropylmalate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0003861 - 3-isopropylmalate dehydratase activity [Evidence IMP] [PMID 5724969]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IMP] [PMID 5724969]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IMP] [PMID 6323436]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4089	Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9191025]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 10942767]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 9191025]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 10942767]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA,IPI] [PMID 9927435]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 10942767]
AWJ20_4091	Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008808 - cardiolipin synthase activity [Evidence IDA] [PMID 7564918]; GO_function: GO:0008808 - cardiolipin synthase activity [Evidence IMP] [PMID 9614098]; GO_function: GO:0016780 - phosphotransferase activity, for other substituted phosphate groups [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 18799619]; GO_process: GO:0008610 - lipid biosynthetic process [Evidence IDA] [PMID 7564918]; GO_process: GO:0008610 - lipid biosynthetic process [Evidence IMP] [PMID 9614098]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0007006 - mitochondrial membrane organization [Evidence IMP] [PMID 10777514]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
AWJ20_4092	Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
AWJ20_4094	Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IMP] [PMID 15319434]; GO_process: GO:0006417 - regulation of translation [Evidence IGI] [PMID 15319434]
AWJ20_4095	Essential component of the TIM23 complex; with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core Translocase of the Inner Mitochondrial membrane (TIM23 complex); GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 15618217]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IPI] [PMID 7600576]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015266 - protein channel activity [Evidence IMP] [PMID 11344168]; GO_function: GO:0015266 - protein channel activity [Evidence IMP] [PMID 15618217]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 18826960]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 11344168]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 15618217]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 7600576]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 7919535]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4100	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 7599275]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 7599275]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IEA]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IMP] [PMID 19602197]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 7599275]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0004809 - tRNA (guanine-N2-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0004809 - tRNA (guanine-N2-)-methyltransferase activity [Evidence IDA,IMP] [PMID 9801306]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 2426253]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_4101	Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence ISS] [PMID 11101532]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15024427]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 18327269]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0001308 - negative regulation of chromatin silencing involved in replicative cell aging [Evidence IGI,IMP] [PMID 9150138]; GO_process: GO:0017148 - negative regulation of translation [Evidence IDA] [PMID 20427513]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IGI] [PMID 11101532]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 9150138]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4103	Plasma membrane H+-ATPase; pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 10716729]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 15536122]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11739806]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0008553 - hydrogen-exporting ATPase activity, phosphorylative mechanism [Evidence IEA]; GO_function: GO:0008553 - hydrogen-exporting ATPase activity, phosphorylative mechanism [Evidence IDA] [PMID 17912695]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:1902906 - proteasome storage granule assembly [Evidence IMP] [PMID 23690178]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IDA] [PMID 8396147]; GO_process: GO:0006885 - regulation of pH [Evidence IEP] [PMID 8929277]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 8396147]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4104	Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 20080635]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15797381]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 15078868]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 15797381]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20080635]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 15078868]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA,IMP] [PMID 15797381]; GO_process: GO:0051788 - response to misfolded protein [Evidence IMP] [PMID 15797381]
AWJ20_4105	Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004131 - cytosine deaminase activity [Evidence IEA]; GO_function: GO:0004131 - cytosine deaminase activity [Evidence IDA] [PMID 15535715]; GO_function: GO:0004131 - cytosine deaminase activity [Evidence IDA] [PMID 9000374]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0044206 - UMP salvage [Evidence IEA]; GO_process: GO:0046087 - cytidine metabolic process [Evidence IMP] [PMID 10501935]; GO_process: GO:0019858 - cytosine metabolic process [Evidence IMP] [PMID 9000374]; GO_process: GO:0008655 - pyrimidine-containing compound salvage [Evidence IMP] [PMID 9000374]
AWJ20_4106	Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 3281936]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence ISS] [PMID 2675832]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IDA] [PMID 3281936]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0015923 - mannosidase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence ISS] [PMID 2675832]; GO_process: GO:0006013 - mannose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009313 - oligosaccharide catabolic process [Evidence IMP] [PMID 12723970]
AWJ20_4107	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_4108	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0044611 - nuclear pore inner ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 12509452]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 17418788]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 19414606]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IGI] [PMID 19414608]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IGI] [PMID 20498018]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 11290711]; GO_process: GO:0070869 - heterochromatin assembly involved in chromatin silencing [Evidence IMP] [PMID 23452847]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI,IMP,IPI] [PMID 12473689]; GO_process: GO:0051292 - nuclear pore complex assembly [Evidence IGI] [PMID 19414608]; GO_process: GO:0051292 - nuclear pore complex assembly [Evidence IGI] [PMID 20498018]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IEA]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 10684247]; GO_process: GO:0036228 - protein targeting to nuclear inner membrane [Evidence IMP] [PMID 16929305]; GO_process: GO:0036228 - protein targeting to nuclear inner membrane [Evidence IMP] [PMID 21659568]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4109	pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23019326]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 10821185]; GO_process: GO:0071469 - cellular response to alkalinity [Evidence IMP] [PMID 23019326]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IGI,IMP] [PMID 16524906]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10821185]
AWJ20_4111	Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005664 - nuclear origin of replication recognition complex [Evidence IDA,IMP] [PMID 9372948]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000808 - origin recognition complex [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 16716188]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 12897051]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]
AWJ20_4114	Peroxisomal signal receptor for peroxisomal matrix proteins; recognizes the N-terminal nonapeptide signal (PTS2); WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15545321]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 7957058]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 15545321]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 7535304]; GO_function: GO:0005053 - peroxisome matrix targeting signal-2 binding [Evidence IPI] [PMID 8636211]; GO_function: GO:0005053 - peroxisome matrix targeting signal-2 binding [Evidence IDA] [PMID 8670791]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 10087260]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 9094717]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4115	Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004766 - spermidine synthase activity [Evidence IEA]; GO_function: GO:0004766 - spermidine synthase activity [Evidence IMP,ISS] [PMID 9073064]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006596 - polyamine biosynthetic process [Evidence IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IMP] [PMID 9073064]
AWJ20_4116	Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0004108 - citrate (Si)-synthase activity [Evidence IEA,IEA]; GO_function: GO:0004108 - citrate (Si)-synthase activity [Evidence IDA,IMP] [PMID 17570335]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0046912 - transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Evidence IEA]; GO_process: GO:0046356 - acetyl-CoA catabolic process [Evidence IDA,IMP] [PMID 17570335]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006101 - citrate metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
AWJ20_4118	Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 7619074]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence IDA] [PMID 7619074]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence IDA] [PMID 782885]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence IDA] [PMID 782885]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4120	Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 20477991]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16301316]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 16301316]; GO_process: GO:0000902 - cell morphogenesis [Evidence IMP,ISS] [PMID 10931277]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IMP] [PMID 16301316]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4121	S-adenosylmethionine-dependent methyltransferase; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC; member of the seven beta-strand family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0035657 - eRF1 methyltransferase complex [Evidence IPI] [PMID 17008308]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA,IMP] [PMID 16321977]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008276 - protein methyltransferase activity [Evidence IEA]; GO_function: GO:0008276 - protein methyltransferase activity [Evidence IDA] [PMID 15509572]; GO_function: GO:0008276 - protein methyltransferase activity [Evidence IDA] [PMID 17008308]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0018364 - peptidyl-glutamine methylation [Evidence IDA] [PMID 15509572]; GO_process: GO:0018364 - peptidyl-glutamine methylation [Evidence IDA] [PMID 17008308]; GO_process: GO:0006417 - regulation of translation [Evidence IDA] [PMID 15509572]; GO_process: GO:0006417 - regulation of translation [Evidence IDA] [PMID 16321977]
AWJ20_4122	Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 11842115]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11842115]; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0071008 - U2-type post-mRNA release spliceosomal complex [Evidence IDA] [PMID 11105756]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0000785 - chromatin [Evidence IDA] [PMID 11973290]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11973290]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11973290]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 11105756]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 11842115]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IC] [PMID 11105756]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP,IPI] [PMID 11973290]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000354 - cis assembly of pre-catalytic spliceosome [Evidence IMP,IPI] [PMID 10445879]; GO_process: GO:0000354 - cis assembly of pre-catalytic spliceosome [Evidence IMP] [PMID 12509417]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_4123	Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000243 - commitment complex [Evidence IDA] [PMID 10376880]; GO_component: GO:0000243 - commitment complex [Evidence IDA] [PMID 9150140]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0045131 - pre-mRNA branch point binding [Evidence IDA] [PMID 9182766]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 9182766]
AWJ20_4125	NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 10341420]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0097038 - perinuclear endoplasmic reticulum [Evidence IDA] [PMID 22586098]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IMP] [PMID 22586098]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016722 - oxidoreductase activity, oxidizing metal ions [Evidence ISA] [PMID 10341420]; GO_function: GO:0016175 - superoxide-generating NADPH oxidase activity [Evidence IMP] [PMID 22586098]; GO_process: GO:0006915 - apoptotic process [Evidence IGI] [PMID 22586098]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0032956 - regulation of actin cytoskeleton organization [Evidence IMP] [PMID 22586098]
AWJ20_4127	Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IEA]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 10523662]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 9099738]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IEA]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_4128	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IDA,ISS] [PMID 7836424]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0018548 - pentaerythritol trinitrate reductase activity [Evidence IEA]; GO_function: GO:0052690 - trichloro-p-hydroquinone reductive dehalogenase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17897954]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4131	Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 11038181]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031304 - intrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 19505460]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030061 - mitochondrial crista [Evidence IDA] [PMID 19505460]; GO_component: GO:0097002 - mitochondrial inner boundary membrane [Evidence IDA] [PMID 19505460]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 11038181]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 12707284]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISA] [PMID 11038181]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0061025 - membrane fusion [Evidence IDA] [PMID 22977249]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IDA] [PMID 12566426]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IMP,IPI] [PMID 12808034]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 1532158]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 15125685]
AWJ20_4133	Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004373 - glycogen (starch) synthase activity [Evidence IEA,IEA]; GO_function: GO:0004373 - glycogen (starch) synthase activity [Evidence IDA] [PMID 2123485]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IGI,IMP,ISS] [PMID 1908457]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4135	Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004301 - epoxide hydrolase activity [Evidence IDA,ISS] [PMID 15769598]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009636 - response to toxic substance [Evidence ISS] [PMID 15769598]
AWJ20_4136	Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 9559855]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 9742088]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 20371607]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 9742088]; GO_function: GO:0005371 - tricarboxylate secondary active transmembrane transporter activity [Evidence IDA] [PMID 20371607]; GO_function: GO:0005371 - tricarboxylate secondary active transmembrane transporter activity [Evidence IDA] [PMID 9559855]; GO_process: GO:0015742 - alpha-ketoglutarate transport [Evidence IDA] [PMID 20371607]; GO_process: GO:0006843 - mitochondrial citrate transport [Evidence IDA] [PMID 20371607]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI,IMP] [PMID 9742088]; GO_process: GO:0006842 - tricarboxylic acid transport [Evidence IDA] [PMID 9559855]
AWJ20_4137	Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 2141026]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IPI] [PMID 14998992]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 22842922]; GO_function: GO:0051082 - unfolded protein binding [Evidence IPI] [PMID 14998992]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IEA]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP,IPI] [PMID 14998992]
AWJ20_4139	Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18045534]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0016363 - nuclear matrix [Evidence IDA] [PMID 8366091]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IDA] [PMID 9774653]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence TAS] [PMID 11959996]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 9802895]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0071528 - tRNA re-export from nucleus [Evidence IGI] [PMID 20032305]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4140	Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004164 - diphthine synthase activity [Evidence IEA,IEA]; GO_function: GO:0004164 - diphthine synthase activity [Evidence IMP] [PMID 1508200]; GO_function: GO:0004164 - diphthine synthase activity [Evidence IDA] [PMID 3042777]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA,IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 1508200]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IDA] [PMID 3042777]
AWJ20_4141	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4143	Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria; GO_component: GO:0005948 - acetolactate synthase complex [Evidence IDA] [PMID 10213630]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence IEA]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence IDA] [PMID 8972574]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 8972574]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IDA,ISS] [PMID 8972574]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
AWJ20_4146	Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10725229]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10725229]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 7622450]; GO_process: GO:0006606 - protein import into nucleus [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 19141610]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 16929305]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4148	ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10745074]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IGI] [PMID 3302682]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8151709]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence ISS] [PMID 8151709]; GO_function: GO:0051082 - unfolded protein binding [Evidence IGI] [PMID 9789005]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 8754838]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 24855027]; GO_process: GO:0006457 - protein folding [Evidence IGI] [PMID 9789005]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_4149	EFY87247|glutathione S-transferase [Metarhizium acridum CQMa 102]
AWJ20_4150	High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen appears to be required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 24124599]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 9092527]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 10545175]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IEA,IEA]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IDA,IMP] [PMID 10545175]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IMP] [PMID 1379856]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0015410 - manganese-transporting ATPase activity [Evidence IDA] [PMID 10801856]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA,IMP] [PMID 10545175]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI] [PMID 23569283]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 1379856]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006828 - manganese ion transport [Evidence IDA] [PMID 10801856]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4151	Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15090619]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15090619]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA,IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IDA] [PMID 15766245]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034963 - box C/D snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0034964 - box H/ACA snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 17991894]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,IMP] [PMID 17158880]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 17991894]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 17991894]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 22576366]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IDA,IMP,IPI] [PMID 19818713]
AWJ20_4153	Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 15565172]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 16314500]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 16314500]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IDA] [PMID 8566755]
AWJ20_4154	hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4155	adhesion and aggregation factor identified by ability to make transformed S. cerevisiae clump and stick to polystyrene beads
AWJ20_4156	Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; GO_component: GO:0031510 - SUMO activating enzyme complex [Evidence IPI] [PMID 9312010]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7629121]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019948 - SUMO activating enzyme activity [Evidence IDA,IMP] [PMID 9312010]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008641 - small protein activating enzyme activity [Evidence IEA]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0016925 - protein sumoylation [Evidence IEA]; GO_process: GO:0016925 - protein sumoylation [Evidence IDA,IMP] [PMID 9312010]
AWJ20_4157	Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IEA]; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IDA] [PMID 11598210]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IC] [PMID 11598210]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP] [PMID 11598210]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP] [PMID 7730400]
AWJ20_4159	Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IPI] [PMID 9700157]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030905 - retromer complex, outer shell [Evidence IPI] [PMID 9700157]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4161	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 14729968]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 14729968]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 2556404]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4163	Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9575223]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008559 - xenobiotic-transporting ATPase activity [Evidence IDA,IMP] [PMID 23270647]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042908 - xenobiotic transport [Evidence IDA,IMP] [PMID 23270647]
AWJ20_4165	Neurospora crassa e-Compendium ncu10311.3
AWJ20_4167	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4168	Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0052904 - N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052903 - N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IMP] [PMID 11154694]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IDA] [PMID 21067138]; GO_function: GO:0052902 - spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052901 - spermine:oxygen oxidoreductase (spermidine-forming) activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006598 - polyamine catabolic process [Evidence IGI,IMP] [PMID 12586697]
AWJ20_4169	Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0000034 - adenine deaminase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0000034 - adenine deaminase activity [Evidence IDA,IMP] [PMID 1577682]; GO_function: GO:0019239 - deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006146 - adenine catabolic process [Evidence IEA,IEA]; GO_process: GO:0006146 - adenine catabolic process [Evidence IDA,IMP] [PMID 1577682]; GO_process: GO:0043103 - hypoxanthine salvage [Evidence IEA]; GO_process: GO:0043103 - hypoxanthine salvage [Evidence IDA,IMP] [PMID 1577682]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA]; GO_process: GO:0009168 - purine ribonucleoside monophosphate biosynthetic process [Evidence IEA]; GO_process: GO:0043101 - purine-containing compound salvage [Evidence IDA,IMP] [PMID 1577682]
AWJ20_4170	Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; GO_component: GO:0030428 - cell septum [Evidence IDA] [PMID 12455695]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence ISS] [PMID 11747810]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11935221]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence IGI] [PMID 12455695]; GO_function: GO:0052861 - glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group [Evidence IEA,IEA]; GO_function: GO:0052862 - glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0016998 - cell wall macromolecule catabolic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IEP,ISS] [PMID 11747810]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 16328626]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4171	Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_4175	Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0031901 - early endosome membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 9427746]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 15973437]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 14981247]; GO_process: GO:0048193 - Golgi vesicle transport [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9427746]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11739407]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_4176	Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21441304]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 21441304]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IGI,IMP,IPI] [PMID 21441304]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4177	Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19520826]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19520826]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008821 - crossover junction endodeoxyribonuclease activity [Evidence IDA,IMP] [PMID 19020614]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA,IEA]; GO_function: GO:0000014 - single-stranded DNA endodeoxyribonuclease activity [Evidence ISS] [PMID 9683672]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI] [PMID 20106725]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 20106725]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]
AWJ20_4182	Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
AWJ20_4183	Sumoylated protein localizing to the nuclear periphery of mother cells; localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 18336552]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 15598824]; GO_process: GO:0016925 - protein sumoylation [Evidence IGI] [PMID 11606525]; GO_process: GO:0010224 - response to UV-B [Evidence IMP] [PMID 11606770]; GO_process: GO:0010224 - response to UV-B [Evidence IMP] [PMID 15598824]; GO_process: GO:0010225 - response to UV-C [Evidence IMP] [PMID 11606770]; GO_process: GO:0010225 - response to UV-C [Evidence IMP] [PMID 15598824]
AWJ20_4184	Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11149918]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11149918]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005819 - spindle [Evidence IDA] [PMID 11149918]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IDA] [PMID 11081625]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 18321989]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP,IPI] [PMID 9635435]; GO_process: GO:0034048 - negative regulation of protein phosphatase type 2A activity [Evidence IMP,IPI] [PMID 16713564]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IGI,IPI] [PMID 12598903]; GO_process: GO:0032888 - regulation of mitotic spindle elongation [Evidence IGI,IMP] [PMID 18430955]
AWJ20_4186	Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4187	5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046523 - S-methyl-5-thioribose-1-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0046523 - S-methyl-5-thioribose-1-phosphate isomerase activity [Evidence IDA,ISS] [PMID 15215245]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0019284 - L-methionine biosynthetic process from S-adenosylmethionine [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 15215245]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]
AWJ20_4188	Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 9756928]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9756928]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9756928]
AWJ20_4189	Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IC] [PMID 12819204]; GO_process: GO:0006379 - mRNA cleavage [Evidence IMP] [PMID 10619842]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 10619842]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_4190	Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 19665976]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 19665976]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 19665976]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IGI] [PMID 19665976]; GO_process: GO:0016320 - endoplasmic reticulum membrane fusion [Evidence IDA,IGI,IMP] [PMID 22508509]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IEA]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IGI,IGI] [PMID 19665976]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IGI] [PMID 22508509]; GO_process: GO:0061024 - membrane organization [Evidence IGI] [PMID 12427979]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_4191	Plasma membrane hypothetical protein; truncation and overexpression suppresses lethality of G-alpha protein deficiency; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 7592711]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 7592711]
AWJ20_4192	top hit is XP_007344833.1 originated in Auricularia delicata TFB-10046 SS5
AWJ20_4194	Putative aminophospholipid translocase (flippase); involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15314152]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 12960419]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15314152]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence ISS] [PMID 9224683]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence ISS] [PMID 12221123]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 15314152]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IEA,IEA]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 12960419]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 15314152]
AWJ20_4195	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9420330]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4198	Essential component of the TIM23 complex; involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel; TIM23 complex is short for the translocase of the inner mitochondrial membrane; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IPI] [PMID 7600576]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IEA]; GO_function: GO:0030943 - mitochondrion targeting sequence binding [Evidence IDA,IMP] [PMID 8858146]; GO_function: GO:0015266 - protein channel activity [Evidence IDA] [PMID 11713477]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 10830167]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 7600576]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4199	Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 6143574]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003840 - gamma-glutamyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003840 - gamma-glutamyltransferase activity [Evidence IMP] [PMID 11672438]; GO_function: GO:0036374 - glutathione hydrolase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IMP] [PMID 11672438]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006805 - xenobiotic metabolic process [Evidence IMP] [PMID 16857395]
AWJ20_4200	Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog, GSC2, that arose from the whole genome duplication; GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IEA]; GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IDA] [PMID 7983071]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11856368]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11856368]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8602515]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11856368]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8602515]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11856368]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IEA,IEA]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IDA,IMP] [PMID 7528927]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IDA] [PMID 7649185]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IEA]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 7528927]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0008360 - regulation of cell shape [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]
AWJ20_4201	Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; localizes to cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at nuclear periphery; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 18462190]; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005621 - cellular bud scar [Evidence IDA] [PMID 19793924]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 19793924]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 10716729]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 19541632]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 1824714]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19793924]; GO_component: GO:0000936 - primary cell septum [Evidence IDA] [PMID 19793924]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 10809732]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 15355340]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 17397106]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006342 - chromatin silencing [Evidence IMP,IPI] [PMID 19541632]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 15645503]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16986442]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 9515908]
AWJ20_4203	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9238021]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9238021]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IDA] [PMID 11694505]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 11274141]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI] [PMID 9238021]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 16651379]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007088 - regulation of mitosis [Evidence IMP] [PMID 14697200]; GO_process: GO:0060188 - regulation of protein desumoylation [Evidence IMP,IPI] [PMID 17403926]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4204	Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0005955 - calcineurin complex [Evidence IPI] [PMID 10887154]; GO_component: GO:0005955 - calcineurin complex [Evidence IDA] [PMID 1321337]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence ISS] [PMID 11015619]; GO_function: GO:0004723 - calcium-dependent protein serine/threonine phosphatase activity [Evidence IDA,ISS] [PMID 1321337]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 1321337]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 8798496]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 7530227]
AWJ20_4205	Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0034729 - histone H3-K79 methylation [Evidence IMP] [PMID 18158898]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0043935 - sexual sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 20713519]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
AWJ20_4209	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 16427015]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA] [PMID 16427015]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 15755922]
AWJ20_4210	C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23045392]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23212245]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11452010]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23212245]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23045392]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA,IDA] [PMID 23212245]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 23045392]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 23045392]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 23212245]
AWJ20_4211	Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; CCT is short for chaperonin containing TCP-1; essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 10749875]; GO_function: GO:0031683 - G-protein beta/gamma-subunit complex binding [Evidence IDA] [PMID 10749875]; GO_function: GO:0003779 - actin binding [Evidence IDA,IMP] [PMID 19501098]; GO_process: GO:0009968 - negative regulation of signal transduction [Evidence IEA]; GO_process: GO:0007329 - positive regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IMP,IPI] [PMID 10749875]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 19501098]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]
AWJ20_4213	Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10092523]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0015250 - water channel activity [Evidence IGI,IMP,ISS] [PMID 9765289]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 15583134]; GO_process: GO:0006810 - transport [Evidence IEA,IEA,IEA]; GO_process: GO:0006833 - water transport [Evidence IMP] [PMID 9765289]
AWJ20_4217	S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IEA]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 12872006]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 16005430]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IDA] [PMID 16642040]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 16005430]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16642040]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 17150819]
AWJ20_4218	Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 8524252]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 11046133]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 8524252]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4219	Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15282305]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4222	Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005664 - nuclear origin of replication recognition complex [Evidence IDA,IMP] [PMID 9372948]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000808 - origin recognition complex [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9159120]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9288745]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 16716188]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 7579692]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 12897051]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 16980387]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IMP] [PMID 18845545]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]
AWJ20_4223	Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15544818]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16850348]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0008198 - ferrous iron binding [Evidence IDA] [PMID 22031445]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 9367751]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IMP] [PMID 7941734]; GO_process: GO:0052837 - thiazole biosynthetic process [Evidence IEA]; GO_process: GO:0052837 - thiazole biosynthetic process [Evidence IDA] [PMID 22031445]
AWJ20_4226	Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA,IEA]; GO_component: GO:0008278 - cohesin complex [Evidence IEA]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 9990856]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003680 - AT DNA binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7929577]; GO_function: GO:0000217 - DNA secondary structure binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 11448778]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 15280507]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 9335333]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 8276886]
AWJ20_4227	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_4228	Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 10497163]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10497163]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IMP,ISS] [PMID 10497163]; GO_function: GO:0004620 - phospholipase activity [Evidence IEA]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IDA,IMP] [PMID 10497163]; GO_process: GO:0006660 - phosphatidylserine catabolic process [Evidence IDA,IMP] [PMID 10497163]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]
AWJ20_4229	Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21127045]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10648791]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21127045]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11212916]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IMP] [PMID 10648791]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IMP] [PMID 19906648]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP,ISS] [PMID 10648791]
AWJ20_4230	Putative nucleotide sugar transporter; has similarity to Vrg4p; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005338 - nucleotide-sugar transmembrane transporter activity [Evidence ISS] [PMID 9395539]; GO_process: GO:0015786 - UDP-glucose transport [Evidence IMP] [PMID 18693752]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0015780 - nucleotide-sugar transport [Evidence ISS] [PMID 9395539]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4231	Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_4233	GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4235	L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004587 - ornithine-oxo-acid transaminase activity [Evidence IEA]; GO_function: GO:0004587 - ornithine-oxo-acid transaminase activity [Evidence IMP] [PMID 3036506]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0055129 - L-proline biosynthetic process [Evidence IEA]; GO_process: GO:0006527 - arginine catabolic process [Evidence NAS] [PMID 14263163]; GO_process: GO:0006527 - arginine catabolic process [Evidence IC] [PMID 3036506]; GO_process: GO:0006591 - ornithine metabolic process [Evidence IMP] [PMID 3036506]
AWJ20_4237	GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8862519]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 8862519]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0050185 - phosphatidylinositol deacylase activity [Evidence IGI] [PMID 14734546]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8862519]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11673477]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IEA]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IGI] [PMID 14734546]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 8862519]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IGI,IMP] [PMID 8862519]
AWJ20_4239	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10198019]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 14665464]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8808622]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0009927 - histidine phosphotransfer kinase activity [Evidence IDA,IMP] [PMID 12455952]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005034 - osmosensor activity [Evidence IDA] [PMID 12821642]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IEA]; GO_function: GO:0000155 - phosphorelay sensor kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IDA] [PMID 8808622]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0006469 - negative regulation of protein kinase activity [Evidence IGI,IMP] [PMID 9482735]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA] [PMID 8808622]; GO_process: GO:0018106 - peptidyl-histidine phosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA,IEA]; GO_process: GO:0046777 - protein autophosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0023014 - signal transduction by phosphorylation [Evidence IEA]
AWJ20_4240	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10903515]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015244 - fluconazole transporter activity [Evidence ISS] [PMID 9235926]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI,IMP] [PMID 10572257]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI] [PMID 9235926]; GO_process: GO:0015893 - drug transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9235926]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4242	Mitochondrial hypothetical protein involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase, ADCK1; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 23781023]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23781023]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0055088 - lipid homeostasis [Evidence IGI] [PMID 23781023]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IGI,IMP] [PMID 23781023]
AWJ20_4243	Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8631921]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IDA] [PMID 8631921]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 8631921]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 8631921]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
AWJ20_4244	RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; the Rpb4p/Rpb7p subcomplex regulates cellular lifespan via an mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12857861]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 16357218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12857861]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 11087726]; GO_function: GO:0003727 - single-stranded RNA binding [Evidence IDA] [PMID 11087726]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IPI] [PMID 21074047]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0031990 - mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 12857861]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IMP] [PMID 16357218]; GO_process: GO:0045948 - positive regulation of translational initiation [Evidence IMP] [PMID 21074047]; GO_process: GO:0034402 - recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 18195044]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11577101]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 11087726]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4246	Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12736687]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12736687]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 12736687]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008936 - nicotinamidase activity [Evidence IEA]; GO_function: GO:0008936 - nicotinamidase activity [Evidence ISS] [PMID 11901108]; GO_function: GO:0008936 - nicotinamidase activity [Evidence IMP] [PMID 19381334]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 11901108]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11901108]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019358 - nicotinate nucleotide salvage [Evidence ISS] [PMID 11901108]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IEP,IMP] [PMID 12736687]
AWJ20_4247	Highly conserved ATPase of HSP70/DnaK family; essential functional component of the EKC/KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; GO_component: GO:0000408 - EKC/KEOPS complex [Evidence IDA] [PMID 16564010]; GO_component: GO:0000408 - EKC/KEOPS complex [Evidence IDA] [PMID 16874308]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16874308]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0031490 - chromatin DNA binding [Evidence IDA] [PMID 16874308]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IMP] [PMID 18439903]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 16874308]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 23620299]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0000723 - telomere maintenance [Evidence IPI] [PMID 16564010]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IGI,IMP] [PMID 23390378]; GO_process: GO:0070526 - threonylcarbamoyladenosine biosynthetic process [Evidence IEA]; GO_process: GO:0070525 - threonylcarbamoyladenosine metabolic process [Evidence IMP] [PMID 21183954]; GO_process: GO:0070525 - threonylcarbamoyladenosine metabolic process [Evidence IMP] [PMID 21459853]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4248	Membrane glycoprotein v-SNARE; involved in retrograde transport from the Golgi to the endoplasmic reticulum (ER); required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 12853481]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 12893879]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 9214619]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8334998]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA,ISM] [PMID 1537327]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 19346454]; GO_function: GO:0005484 - SNAP receptor activity [Evidence ISM] [PMID 12853481]; GO_function: GO:0005484 - SNAP receptor activity [Evidence ISM] [PMID 12893879]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8612273]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048279 - vesicle fusion with endoplasmic reticulum [Evidence IC] [PMID 8612273]; GO_process: GO:0048279 - vesicle fusion with endoplasmic reticulum [Evidence NAS] [PMID 9214619]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_4255	Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 11038180]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 11038182]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP] [PMID 11038180]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP,IPI] [PMID 11038182]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP] [PMID 11038183]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP,IPI] [PMID 11179417]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI,IMP] [PMID 11038182]; GO_process: GO:0016559 - peroxisome fission [Evidence IGI] [PMID 18445678]
AWJ20_4258	Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
AWJ20_4259	Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IPI] [PMID 21724601]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4260	Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19446323]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA,IPI] [PMID 19217412]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 10681183]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19217412]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI] [PMID 19412159]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446322]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446323]
AWJ20_4261	Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p; GO_component: GO:0097344 - Rix1 complex [Evidence IDA] [PMID 14759368]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 22421151]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15528184]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 22421151]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 22421151]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 14759368]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 22421151]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 15528184]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4263	ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15828860]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15935758]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA,IPI] [PMID 15935759]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16541108]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15226447]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8756671]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0034459 - ATP-dependent 3'-5' RNA helicase activity [Evidence IDA,IMP] [PMID 18000032]; GO_function: GO:0034459 - ATP-dependent 3'-5' RNA helicase activity [Evidence IDA] [PMID 18096702]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA] [PMID 18096702]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9463390]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA] [PMID 15828860]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA] [PMID 15935758]; GO_process: GO:0071031 - nuclear mRNA surveillance of mRNA 3'-end processing [Evidence IGI,IMP] [PMID 17410208]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IMP] [PMID 19369424]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 16374505]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18940861]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IGI] [PMID 18000032]; GO_process: GO:0071049 - nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [Evidence IGI] [PMID 11586364]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 10508172]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 9463390]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_4266	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4267	Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 6271]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 9398220]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IMP] [PMID 1100397]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006563 - L-serine metabolic process [Evidence IEA]; GO_process: GO:0006544 - glycine metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IMP] [PMID 1100397]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI] [PMID 9398220]; GO_process: GO:0009070 - serine family amino acid biosynthetic process [Evidence IGI] [PMID 9398220]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
AWJ20_4269	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
AWJ20_4270	Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0042721 - mitochondrial inner membrane protein insertion complex [Evidence IDA] [PMID 10637294]; GO_component: GO:0042721 - mitochondrial inner membrane protein insertion complex [Evidence IDA] [PMID 10648604]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015266 - protein channel activity [Evidence IDA] [PMID 12637749]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IGI] [PMID 10637294]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IMP] [PMID 17893242]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IGI,IMP] [PMID 9412462]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4271	Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis; stabilizes Rpa190p, the largest subunit of RNAP I, by mediating its deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; localized to the nucleolus; human USP36 is a functional analog of Ubp10p; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22902402]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10490600]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 10490600]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 15721261]; GO_process: GO:0016578 - histone deubiquitination [Evidence IMP] [PMID 22829782]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA,IMP] [PMID 15721261]; GO_process: GO:0016579 - protein deubiquitination [Evidence IMP] [PMID 22829782]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_4272	AdoMet-dependent methyltransferase; involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10556316]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10648622]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10556316]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016435 - rRNA (guanine) methyltransferase activity [Evidence IMP] [PMID 15546625]; GO_function: GO:0008650 - rRNA (uridine-2'-O-)-methyltransferase activity [Evidence IGI] [PMID 14636587]; GO_function: GO:0008649 - rRNA methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10556316]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10648622]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10556316]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10648622]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IGI] [PMID 14636587]; GO_process: GO:0031167 - rRNA methylation [Evidence IDA,IGI,IMP] [PMID 15546625]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4274	Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; mutations in human homolog cause insulin-responsive hyperglycemia; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 9866716]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IDA] [PMID 18975895]; GO_function: GO:0009055 - electron carrier activity [Evidence IDA] [PMID 7851399]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen [Evidence IDA] [PMID 7851399]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IDA] [PMID 7851399]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_4275	Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10409731]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0043200 - response to amino acid [Evidence IMP] [PMID 10409731]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4276	Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 11018040]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 10094305]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11018040]; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 10094305]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0071014 - post-mRNA release spliceosomal complex [Evidence IDA] [PMID 10094305]; GO_component: GO:0071020 - post-spliceosomal complex [Evidence IDA] [PMID 10094305]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IGI] [PMID 16103217]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IC] [PMID 10094305]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 10094305]; GO_process: GO:0000389 - mRNA 3'-splice site recognition [Evidence IMP] [PMID 16103217]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
AWJ20_4278	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 9748433]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4281	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; YPS1 has a paralog, MKC7, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA] [PMID 8389368]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0016485 - protein processing [Evidence IDA] [PMID 8626758]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_4282	Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence TAS] [PMID 11279090]; GO_component: GO:0005746 - mitochondrial respiratory chain [Evidence TAS] [PMID 11279090]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0045153 - electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity [Evidence IMP] [PMID 11279090]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IMP] [PMID 11279090]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006119 - oxidative phosphorylation [Evidence TAS] [PMID 11279090]
AWJ20_4283	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17452534]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 9560389]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IEA]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IMP] [PMID 9438131]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IDA,IMP] [PMID 9565610]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA] [PMID 10224048]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 9438131]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 9560389]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4286	tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14690591]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24249226]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24249226]; GO_function: GO:0042781 - 3'-tRNA processing endoribonuclease activity [Evidence IDA] [PMID 12711671]; GO_function: GO:0042781 - 3'-tRNA processing endoribonuclease activity [Evidence IDA] [PMID 24249226]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:1990180 - mitochondrial tRNA 3'-end processing [Evidence IDA,IMP] [PMID 24249226]; GO_process: GO:0042780 - tRNA 3'-end processing [Evidence IDA] [PMID 24249226]; GO_process: GO:0034414 - tRNA 3'-trailer cleavage, endonucleolytic [Evidence IDA] [PMID 12711671]; GO_process: GO:0034414 - tRNA 3'-trailer cleavage, endonucleolytic [Evidence IMP] [PMID 24249226]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_4289	Essential nuclear envelope integral membrane protein; required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11483521]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IGI] [PMID 20016074]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 11483521]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 11483521]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4290	Nuclear protein with decapping endonuclease activity; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10805743]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12612077]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0034353 - RNA pyrophosphohydrolase activity [Evidence IDA] [PMID 20802481]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 10805743]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:1990174 - phosphodiesterase decapping endonuclease activity [Evidence IDA,IMP] [PMID 20802481]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10805743]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10805743]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 16131592]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IDA,IMP] [PMID 20802481]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled [Evidence IMP] [PMID 15565157]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4291	Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog, YKR078W, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9175702]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 9175702]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 9700157]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030905 - retromer complex, outer shell [Evidence IPI] [PMID 9700157]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4292	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; expression is glucose-repressible; GO_component: GO:0031417 - NatC complex [Evidence IDA] [PMID 10504710]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IMP] [PMID 11274203]; GO_process: GO:0006474 - N-terminal protein amino acid acetylation [Evidence IMP] [PMID 11274203]
AWJ20_4293	Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 20841380]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15550248]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 16520372]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,ISS] [PMID 8299420]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 15265985]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI,IMP] [PMID 20841380]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20841380]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0016559 - peroxisome fission [Evidence IMP] [PMID 18445678]; GO_process: GO:0007031 - peroxisome organization [Evidence IDA,IGI,IMP] [PMID 12707309]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8299420]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP] [PMID 8299420]
AWJ20_4294	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_4295	Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0071627 - integral component of fungal-type vacuolar membrane [Evidence IDA] [PMID 23169667]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015326 - cationic amino acid transmembrane transporter activity [Evidence IMP,ISO] [PMID 23169667]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0034488 - basic amino acid transmembrane export from vacuole [Evidence IMP,ISO] [PMID 23169667]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4296	Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005654 - nucleoplasm [Evidence IPI] [PMID 8631901]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA] [PMID 17850751]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA] [PMID 1840648]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031123 - RNA 3'-end processing [Evidence IEA]; GO_process: GO:0043631 - RNA polyadenylation [Evidence IEA]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 1840648]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 8524265]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0071050 - snoRNA polyadenylation [Evidence IGI] [PMID 18951092]
AWJ20_4297	Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IGI,IMP] [PMID 18957409]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0018026 - peptidyl-lysine monomethylation [Evidence IGI,IMP] [PMID 18957409]
AWJ20_4298	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8858151]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9575221]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 14761951]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA,IPI] [PMID 8858151]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 9575221]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14761951]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9575221]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 8858151]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 9575221]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 8858151]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IDA] [PMID 8858151]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 10982821]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 8858151]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 9575221]
AWJ20_4300	Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9852143]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852143]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 9755161]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 9852143]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,ISS] [PMID 9755161]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4301	Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IDA] [PMID 10855721]; GO_process: GO:0006083 - acetate metabolic process [Evidence IDA] [PMID 10855721]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]
AWJ20_4308	Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; GO_component: GO:0016021 - integral component of membrane [Evidence IBA,IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7828591]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 16754360]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IMP,ISS] [PMID 7828591]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9428742]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IBA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_4310	Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 17093059]; GO_component: GO:0030140 - trans-Golgi network transport vesicle [Evidence IDA] [PMID 12221123]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 16452632]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 16452632]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]
AWJ20_4312	Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 17093059]; GO_component: GO:0030140 - trans-Golgi network transport vesicle [Evidence IDA] [PMID 12221123]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 16452632]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 16452632]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]
AWJ20_4313	Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4314	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17897954]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IDA,ISS] [PMID 8454584]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0018548 - pentaerythritol trinitrate reductase activity [Evidence IEA]; GO_function: GO:0052690 - trichloro-p-hydroquinone reductive dehalogenase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17897954]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4315	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17897954]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IDA,ISS] [PMID 8454584]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0018548 - pentaerythritol trinitrate reductase activity [Evidence IEA]; GO_function: GO:0052690 - trichloro-p-hydroquinone reductive dehalogenase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17897954]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4316	Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4318	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19218425]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9036858]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 9036858]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IGI,IMP] [PMID 16782869]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 21840851]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12455687]; GO_process: GO:0036003 - positive regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IDA] [PMID 9036858]; GO_process: GO:0010527 - positive regulation of transposition, RNA-mediated [Evidence IMP] [PMID 10652102]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 8730867]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IDA,IMP] [PMID 9036858]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9055077]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4319	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14980713]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15356260]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 15356260]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IGI] [PMID 11110666]; GO_process: GO:0038032 - termination of G-protein coupled receptor signaling pathway [Evidence IEA]
AWJ20_4321	Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_4322	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10198019]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 14665464]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8808622]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0009927 - histidine phosphotransfer kinase activity [Evidence IDA,IMP] [PMID 12455952]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005034 - osmosensor activity [Evidence IDA] [PMID 12821642]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IEA]; GO_function: GO:0000155 - phosphorelay sensor kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IDA] [PMID 8808622]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0006469 - negative regulation of protein kinase activity [Evidence IGI,IMP] [PMID 9482735]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA] [PMID 8808622]; GO_process: GO:0018106 - peptidyl-histidine phosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA,IEA]; GO_process: GO:0046777 - protein autophosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0023014 - signal transduction by phosphorylation [Evidence IEA]
AWJ20_4324	Putative amidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004040 - amidase activity [Evidence IEA]; GO_function: GO:0004040 - amidase activity [Evidence ISS] [PMID 2263500]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
AWJ20_4329	Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 20008566]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11408574]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20008566]; GO_function: GO:0008142 - oxysterol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0015248 - sterol transporter activity [Evidence IDA] [PMID 20008566]; GO_process: GO:0035621 - ER to Golgi ceramide transport [Evidence IMP] [PMID 24213531]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 15173322]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17004323]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IGI] [PMID 12054531]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IGI] [PMID 12054531]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IGI] [PMID 17004323]; GO_process: GO:0010922 - positive regulation of phosphatase activity [Evidence IDA] [PMID 21295699]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 12054531]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 17082746]; GO_process: GO:0015918 - sterol transport [Evidence IGI,IMP] [PMID 16585271]; GO_process: GO:0015918 - sterol transport [Evidence IDA] [PMID 20008566]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_4330	Vacuolar membrane hypothetical protein; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 10637174]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4331	Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11743162]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11901111]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_function: GO:0017024 - myosin I binding [Evidence IPI] [PMID 11901111]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IPI] [PMID 11901111]
AWJ20_4332	S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004478 - methionine adenosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004478 - methionine adenosyltransferase activity [Evidence IDA] [PMID 18078345]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006556 - S-adenosylmethionine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006556 - S-adenosylmethionine biosynthetic process [Evidence IMP] [PMID 17426150]; GO_process: GO:0006555 - methionine metabolic process [Evidence IMP] [PMID 4585174]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]
AWJ20_4333	Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence ISM] [PMID 15466869]; GO_function: GO:0043723 - 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity [Evidence IMP] [PMID 4555411]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008835 - diaminohydroxyphosphoribosylaminopyrimidine deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 15466869]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence ISS] [PMID 8710514]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 4555411]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 15466869]
AWJ20_4334	Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9238021]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9238021]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IDA] [PMID 11694505]; GO_function: GO:0008565 - protein transporter activity [Evidence IPI] [PMID 9182759]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9321403]; GO_process: GO:0006607 - NLS-bearing protein import into nucleus [Evidence IMP] [PMID 11694505]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 11352936]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:2000220 - regulation of pseudohyphal growth [Evidence IMP] [PMID 22043304]; GO_process: GO:0006610 - ribosomal protein import into nucleus [Evidence IMP] [PMID 9321403]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4336	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0000048 - peptidyltransferase activity [Evidence ISS] [PMID 9445368]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4337	Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12649274]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0051183 - vitamin transporter activity [Evidence IDA] [PMID 12649274]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0051180 - vitamin transport [Evidence IDA] [PMID 12649274]
AWJ20_4339	UDP-glucose-4-epimerase; catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 14764091]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IEA,IEA]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IMP] [PMID 14158615]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IDA] [PMID 14764091]; GO_function: GO:0004034 - aldose 1-epimerase activity [Evidence IEA]; GO_function: GO:0004034 - aldose 1-epimerase activity [Evidence IDA] [PMID 14764091]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IMP] [PMID 14158615]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IDA] [PMID 14764091]; GO_process: GO:0006012 - galactose metabolic process [Evidence IEA,IEA,IEA]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4340	Coactivator, regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing; regulated by acetylation and phosphorylation at different growth states via TORC1 signaling; IFH1 has a paralog, CRF1, that arose from the whole genome duplication; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15620355]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15466158]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15466158]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IGI,IMP] [PMID 15620355]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 9755194]; GO_process: GO:0060963 - positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15616569]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4343	similar to Aspergillus flavus NRRL3357 XP_002376764.1
AWJ20_4344	Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12374754]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16648468]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 16648468]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16648468]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 12374754]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 16648468]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16648468]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16648468]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 16648468]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI] [PMID 17803941]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 18077551]
AWJ20_4345	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; relocalizes to the cytosol in response to hypoxia; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; GO_component: GO:0071819 - DUBm complex [Evidence IDA] [PMID 20395473]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 12052880]; GO_component: GO:0000124 - SAGA complex [Evidence IPI] [PMID 15932941]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 17090597]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IPI] [PMID 15932941]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 18488019]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 20434206]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 15932941]; GO_function: GO:0005198 - structural molecule activity [Evidence IGI,IMP] [PMID 15932941]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 15932941]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 17090597]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 12052880]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 15932941]; GO_process: GO:0016578 - histone deubiquitination [Evidence IMP] [PMID 19226466]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 18488019]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 17090597]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 19226466]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4346	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; BMH2 has a paralog, BMH1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12167636]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 12167636]; GO_function: GO:0050815 - phosphoserine binding [Evidence IMP] [PMID 9822578]; GO_function: GO:0019904 - protein domain specific binding [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 14704161]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI] [PMID 19934224]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IGI] [PMID 9215628]; GO_process: GO:0030437 - ascospore formation [Evidence IGI] [PMID 9215628]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IGI] [PMID 17559233]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IGI] [PMID 9215628]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IMP] [PMID 22785534]; GO_process: GO:0051436 - negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [Evidence IPI] [PMID 17030612]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IGI] [PMID 19934224]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 9215628]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IGI] [PMID 9215628]
AWJ20_4347	G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 15340087]; GO_function: GO:0001965 - G-protein alpha-subunit binding [Evidence IPI] [PMID 17591772]; GO_function: GO:0005092 - GDP-dissociation inhibitor activity [Evidence IDA] [PMID 17591772]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 17591772]; GO_process: GO:0017148 - negative regulation of translation [Evidence IMP] [PMID 15340087]
AWJ20_4348	top hit is XP_002839470.1 originated in Tuber melanosporum Mel28; conserved fungal protein
AWJ20_4349	One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 7744969]; GO_function: GO:0051087 - chaperone binding [Evidence IMP,ISS] [PMID 9817751]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11381090]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IMP] [PMID 9817751]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006986 - response to unfolded protein [Evidence IMP] [PMID 9817751]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4351	Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 12475963]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IGI,ISA] [PMID 8530368]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016717 - oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Evidence IEA]; GO_function: GO:0004768 - stearoyl-CoA 9-desaturase activity [Evidence IEA,IEA]; GO_function: GO:0004768 - stearoyl-CoA 9-desaturase activity [Evidence IMP,ISS] [PMID 1978720]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006636 - unsaturated fatty acid biosynthetic process [Evidence IMP,ISS] [PMID 1978720]
AWJ20_4352	Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004325 - ferrochelatase activity [Evidence IDA] [PMID 11980703]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0043115 - precorrin-2 dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0043115 - precorrin-2 dehydrogenase activity [Evidence IDA] [PMID 10051442]; GO_function: GO:0043115 - precorrin-2 dehydrogenase activity [Evidence IDA] [PMID 11980703]; GO_function: GO:0051266 - sirohydrochlorin ferrochelatase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019354 - siroheme biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019354 - siroheme biosynthetic process [Evidence IMP] [PMID 9003798]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 10051442]
AWJ20_4353	Essential protein required for the accumulation of box C/D snoRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence NAS] [PMID 12837249]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0016074 - snoRNA metabolic process [Evidence IMP] [PMID 12837249]
AWJ20_4354	hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10511544]
AWJ20_4355	Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12853640]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003747 - translation release factor activity [Evidence ISO] [PMID 9746366]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 12853640]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
AWJ20_4356	Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 18824477]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 9580698]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IMP] [PMID 18824477]
AWJ20_4358	hypothetical protein; mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA); GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4359	Epsin-like protein required for endocytosis and actin patch assembly; functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; ENT2 has a paralog, ENT1, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0030276 - clathrin binding [Evidence TAS] [PMID 12461563]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence IMP] [PMID 10449404]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10449404]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 10449404]
AWJ20_4361	Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA] [PMID 12421307]; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0008496 - mannan endo-1,6-alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI] [PMID 15470258]; GO_process: GO:0016052 - carbohydrate catabolic process [Evidence IEA]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IDA] [PMID 12421307]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4362	Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA] [PMID 12421307]; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0008496 - mannan endo-1,6-alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI] [PMID 15470258]; GO_process: GO:0016052 - carbohydrate catabolic process [Evidence IEA]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IDA] [PMID 12421307]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4365	Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004588 - orotate phosphoribosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004588 - orotate phosphoribosyltransferase activity [Evidence IMP] [PMID 4550660]; GO_function: GO:0004588 - orotate phosphoribosyltransferase activity [Evidence IDA] [PMID 9882434]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0044205 - 'de novo' UMP biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0046132 - pyrimidine ribonucleoside biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0046132 - pyrimidine ribonucleoside biosynthetic process [Evidence IDA] [PMID 9882434]
AWJ20_4367	Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0048500 - signal recognition particle [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IDA] [PMID 1313947]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IMP,ISS] [PMID 1313948]; GO_function: GO:0008312 - 7S RNA binding [Evidence IEA]; GO_function: GO:0008312 - 7S RNA binding [Evidence IDA] [PMID 14681587]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IEA]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence IMP] [PMID 1313947]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1313948]
AWJ20_4369	Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 9353282]; GO_function: GO:0080132 - fatty acid alpha-hydroxylase activity [Evidence IMP] [PMID 9353282]; GO_function: GO:0080132 - fatty acid alpha-hydroxylase activity [Evidence IMP] [PMID 9559540]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IMP] [PMID 16652392]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IMP] [PMID 9353282]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IMP] [PMID 9368039]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IGI,IMP] [PMID 9559540]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
AWJ20_4372	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0015124 - allantoate transmembrane transporter activity [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IMP] [PMID 16429164]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IGI,IMP] [PMID 17693598]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015719 - allantoate transport [Evidence IMP] [PMID 3275614]; GO_process: GO:0042938 - dipeptide transport [Evidence IMP] [PMID 16429164]; GO_process: GO:0042938 - dipeptide transport [Evidence IGI,IMP] [PMID 17693598]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IMP] [PMID 16429164]
AWJ20_4373	Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16850348]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 10869563]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 10869563]
AWJ20_4377	potential mitochondrial NADH-ubiquinone oxidoreductase complex I,17.2 kD subunit; similar to N. crassa orf (CAD21387); allele of CaO19.1625
AWJ20_4378	Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0034038 - deoxyhypusine synthase activity [Evidence IEA]; GO_function: GO:0034038 - deoxyhypusine synthase activity [Evidence IDA] [PMID 7629166]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0050983 - deoxyhypusine biosynthetic process from spermidine [Evidence IEA]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IEA,IEA]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IDA] [PMID 7629166]
AWJ20_4379	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 2850178]; GO_component: GO:0005829 - cytosol [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 2850178]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IDA] [PMID 15753074]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IDA,IMP] [PMID 18433446]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IMP] [PMID 2850178]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0019205 - nucleobase-containing compound kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016776 - phosphotransferase activity, phosphate group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006172 - ADP biosynthetic process [Evidence IEA]; GO_process: GO:0006172 - ADP biosynthetic process [Evidence IDA] [PMID 2848829]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 20980819]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IMP] [PMID 2850178]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4380	mRNA 3' end processing factor; essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 12727883]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IMP,IPI] [PMID 15998810]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IMP] [PMID 15998810]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IDA] [PMID 12727883]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IDA,IMP] [PMID 15998810]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4382	Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0001409 - guanine nucleotide transmembrane transporter activity [Evidence IDA] [PMID 14998997]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 14629196]; GO_process: GO:0001408 - guanine nucleotide transport [Evidence IDA] [PMID 14998997]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 14998997]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 8905928]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 14998997]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4387	hypothetical protein; has an apparent role in acetylation of N-terminal methionine residues; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0017196 - N-terminal peptidyl-methionine acetylation [Evidence IMP] [PMID 8175741]
AWJ20_4388	Cytoplasmic GTPase; forms a heterodimer with Gtr2p to stimulate TORC1 in response to amino acids; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB; GO_component: GO:0034448 - EGO complex [Evidence IDA] [PMID 16732272]; GO_component: GO:1990131 - Gtr1-Gtr2 GTPase complex [Evidence IPI] [PMID 10388807]; GO_component: GO:1990131 - Gtr1-Gtr2 GTPase complex [Evidence IPI] [PMID 16143306]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10388807]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15885099]; GO_component: GO:0031902 - late endosome membrane [Evidence IDA] [PMID 16732272]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10388807]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 22726655]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 23716719]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IDA] [PMID 22726655]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 18258182]; GO_process: GO:0006817 - phosphate ion transport [Evidence IEA]; GO_process: GO:0006817 - phosphate ion transport [Evidence IMP] [PMID 1620108]; GO_process: GO:0032008 - positive regulation of TOR signaling [Evidence IDA,IGI,IMP] [PMID 19748353]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IMP,IPI] [PMID 15937128]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IMP,IPI] [PMID 15937128]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4389	Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 350878]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004310 - farnesyl-diphosphate farnesyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004310 - farnesyl-diphosphate farnesyltransferase activity [Evidence IDA] [PMID 8157649]; GO_function: GO:0004310 - farnesyl-diphosphate farnesyltransferase activity [Evidence IDA] [PMID 8323279]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0051996 - squalene synthase activity [Evidence IEA]; GO_function: GO:0051996 - squalene synthase activity [Evidence IDA] [PMID 8157649]; GO_function: GO:0051996 - squalene synthase activity [Evidence IDA] [PMID 8323279]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 1807826]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0008610 - lipid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_4391	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis; possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11469793]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 11469793]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9266513]
AWJ20_4392	Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IPI] [PMID 10733567]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9372940]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000154 - rRNA modification [Evidence TAS] [PMID 10690410]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 10733567]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4393	Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IEA]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 11968008]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IDA] [PMID 2246265]; GO_function: GO:0008235 - metalloexopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0010629 - negative regulation of gene expression [Evidence IMP] [PMID 21124907]; GO_process: GO:0070084 - protein initiator methionine removal [Evidence IEA]; GO_process: GO:0035551 - protein initiator methionine removal involved in protein maturation [Evidence IMP] [PMID 11811952]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_4394	Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
AWJ20_4397	Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19159085]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 12235130]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 21515579]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0001010 - sequence-specific DNA binding transcription factor recruiting transcription factor activity [Evidence IDA,IGI] [PMID 21515579]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 3888627]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7899074]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 7899074]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4398	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
AWJ20_4399	Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 10747087]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 15372079]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 15372079]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10747087]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IGI] [PMID 15958490]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000149 - SNARE binding [Evidence IDA] [PMID 15958490]; GO_function: GO:0019905 - syntaxin binding [Evidence IDA,IMP] [PMID 12186954]; GO_function: GO:0019905 - syntaxin binding [Evidence IDA] [PMID 15372079]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 9545229]; GO_process: GO:0035543 - positive regulation of SNARE complex assembly [Evidence IMP] [PMID 12186954]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 15958490]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IMP] [PMID 8636207]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_4401	ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly; GO_component: GO:0070209 - ASTRA complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0097255 - R2TP complex [Evidence IDA] [PMID 15766533]; GO_component: GO:0097255 - R2TP complex [Evidence IPI] [PMID 18268103]; GO_component: GO:0000812 - Swr1 complex [Evidence IPI] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IPI] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 18234224]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 18268103]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 14690608]; GO_process: GO:0043486 - histone exchange [Evidence IPI] [PMID 14645854]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11278922]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4402	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence ISS] [PMID 7498786]; GO_function: GO:0070403 - NAD+ binding [Evidence IEA]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IMP] [PMID 16815704]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 7498786]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16815704]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0046459 - short-chain fatty acid metabolic process [Evidence IMP] [PMID 12618394]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4403	Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISA] [PMID 23267056]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence ISS] [PMID 14690591]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:1990022 - RNA polymerase III complex localization to nucleus [Evidence IMP] [PMID 23267056]
AWJ20_4404	Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15277543]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 11058603]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence ISS] [PMID 11058603]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IMP] [PMID 11058603]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 11058603]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 15277543]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IMP] [PMID 15277543]
AWJ20_4405	Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19451230]; GO_component: GO:0030532 - small nuclear ribonucleoprotein complex [Evidence IDA] [PMID 19451230]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 19451230]
AWJ20_4406	Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; GO_component: GO:0008180 - COP9 signalosome [Evidence IEA]; GO_component: GO:0008180 - COP9 signalosome [Evidence IDA] [PMID 12446563]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IMP] [PMID 12183637]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 12446563]; GO_process: GO:0010388 - cullin deneddylation [Evidence IMP] [PMID 12186635]; GO_process: GO:0010388 - cullin deneddylation [Evidence IMP] [PMID 12446563]; GO_process: GO:0010388 - cullin deneddylation [Evidence IMP] [PMID 24164706]; GO_process: GO:0070452 - positive regulation of ergosterol biosynthetic process [Evidence IMP] [PMID 24164706]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_4408	Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9649520]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IMP] [PMID 15635094]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16418276]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 15635094]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 9649520]
AWJ20_4410	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 11591390]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IC,IPI] [PMID 11591390]
AWJ20_4411	Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_4412	GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003935 - GTP cyclohydrolase II activity [Evidence IEA,IEA]; GO_function: GO:0019238 - cyclohydrolase activity [Evidence IGI,IMP] [PMID 4555411]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 4555411]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]
AWJ20_4414	Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21880895]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 21880895]; GO_function: GO:0032451 - demethylase activity [Evidence IDA,IMP] [PMID 24739148]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 21880895]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 22188241]
AWJ20_4418	one of two genes similar to Amanita muscaria DOPA-dioxygenase; allele of CaO19.8608
AWJ20_4419	Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 17889667]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 19420139]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 21623367]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 19481524]; GO_process: GO:0000294 - nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [Evidence IDA] [PMID 17889667]; GO_process: GO:0070966 - nuclear-transcribed mRNA catabolic process, no-go decay [Evidence IGI] [PMID 16554824]; GO_process: GO:0070966 - nuclear-transcribed mRNA catabolic process, no-go decay [Evidence IMP] [PMID 19420139]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0045727 - positive regulation of translation [Evidence IMP] [PMID 24424461]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0032790 - ribosome disassembly [Evidence IDA] [PMID 20947765]; GO_process: GO:0032790 - ribosome disassembly [Evidence IMP] [PMID 22770215]; GO_process: GO:0032790 - ribosome disassembly [Evidence IDA,IMP] [PMID 24424461]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4420	Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_4424	Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12514182]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23625923]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000321 - re-entry into mitotic cell cycle after pheromone arrest [Evidence IGI] [PMID 12588993]
AWJ20_4425	Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA; GO_component: GO:0031942 - i-AAA complex [Evidence IDA] [PMID 18843051]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 18843051]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051787 - misfolded protein binding [Evidence IDA] [PMID 18843051]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 18843051]
AWJ20_4428	Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008841 - dihydrofolate synthase activity [Evidence IEA]; GO_function: GO:0008841 - dihydrofolate synthase activity [Evidence IMP] [PMID 11731153]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004326 - tetrahydrofolylpolyglutamate synthase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006761 - dihydrofolate biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IMP] [PMID 11731153]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0046901 - tetrahydrofolylpolyglutamate biosynthetic process [Evidence IEA]
AWJ20_4429	similar to Saccharomyces cerevisiae S288c NP_116617.1
AWJ20_4430	Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 8702485]; GO_function: GO:0009922 - fatty acid elongase activity [Evidence IMP] [PMID 12684876]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0019368 - fatty acid elongation, unsaturated fatty acid [Evidence IMP] [PMID 10850979]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
AWJ20_4432	Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0043527 - tRNA methyltransferase complex [Evidence IDA] [PMID 12403464]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IMP] [PMID 12403464]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IDA] [PMID 17382321]; GO_function: GO:0000049 - tRNA binding [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0036265 - RNA (guanine-N7)-methylation [Evidence IEA,IEA,IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 12403464]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 17382321]; GO_process: GO:0006400 - tRNA modification [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
AWJ20_4433	Vacuolar carboxypeptidase S; expression is induced under low-nitrogen conditions; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 1569061]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IMP] [PMID 2026161]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004181 - metallocarboxypeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IMP] [PMID 2026161]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IMP] [PMID 2026161]
AWJ20_4434	Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in the mobilization of non-polar lipids; found in lipid particles, the endoplasmic reticulum and the mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones; oleic acid inducible; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10617610]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10617610]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0000140 - acylglycerone-phosphate reductase activity [Evidence IEA]; GO_function: GO:0000140 - acylglycerone-phosphate reductase activity [Evidence IMP] [PMID 10617610]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IGI,IMP] [PMID 24187129]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006654 - phosphatidic acid biosynthetic process [Evidence IMP] [PMID 10617610]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI] [PMID 24187129]
AWJ20_4436	Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0018423 - protein C-terminal leucine carboxyl O-methyltransferase activity [Evidence IMP] [PMID 11060018]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006481 - C-terminal protein methylation [Evidence IMP] [PMID 11060018]; GO_process: GO:0043623 - cellular protein complex assembly [Evidence IMP] [PMID 11060018]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0010506 - regulation of autophagy [Evidence IMP] [PMID 23870128]
AWJ20_4439	Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 17604721]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 12475940]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IDA] [PMID 8223424]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_4441	Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, cell cycle progression, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to phagophore assembly site (PAS); plays a role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway; SLT2 has a paralog, KDX1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12361575]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 23924898]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 23924898]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12361575]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23924898]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence ISS] [PMID 8386319]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 20823268]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 24554767]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000165 - MAPK cascade [Evidence IEA,IEA]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 18971375]; GO_process: GO:0000917 - barrier septum assembly [Evidence IGI] [PMID 19633265]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IDA,IMP] [PMID 16380504]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IGI] [PMID 16524906]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 14703512]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 20219973]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 8386319]; GO_process: GO:0042990 - regulation of transcription factor import into nucleus [Evidence IMP] [PMID 20219973]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16087742]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 8386319]
AWJ20_4443	Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004106 - chorismate mutase activity [Evidence IEA,IEA]; GO_function: GO:0004106 - chorismate mutase activity [Evidence IDA] [PMID 3027508]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0009094 - L-phenylalanine biosynthetic process [Evidence IC,IMP] [PMID 3027508]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0046417 - chorismate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006571 - tyrosine biosynthetic process [Evidence IC,IMP] [PMID 3027508]
AWJ20_4444	Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23509072]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16140254]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005342 - organic acid transmembrane transporter activity [Evidence IGI,ISS] [PMID 16140254]; GO_process: GO:0006839 - mitochondrial transport [Evidence IGI] [PMID 16140254]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4445	GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0016023 - cytoplasmic membrane-bounded vesicle [Evidence IDA] [PMID 9508768]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 9508768]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15358789]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12730205]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 9508768]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 15358789]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 9508768]
AWJ20_4446	D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9525904]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IMP,ISS] [PMID 8492799]; GO_function: GO:0008762 - UDP-N-acetylmuramate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8492799]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4447	C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8663358]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8663358]; GO_function: GO:0000254 - C-4 methylsterol oxidase activity [Evidence IEA]; GO_function: GO:0000254 - C-4 methylsterol oxidase activity [Evidence IDA] [PMID 8663358]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8663358]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
AWJ20_4448	DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity stimulated by RPA and Sgs1p-Top2p-Rmi1p; involved in telomere stability and regulation of mitotic recombination; GO_component: GO:0031422 - RecQ helicase-Topo III complex [Evidence IPI] [PMID 15889139]; GO_component: GO:0031422 - RecQ helicase-Topo III complex [Evidence IDA] [PMID 15899853]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1324925]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IDA] [PMID 22885009]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IEA,IEA]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IDA] [PMID 1324925]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 22885009]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 17571075]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI,IMP] [PMID 1328869]; GO_process: GO:0000018 - regulation of DNA recombination [Evidence IMP] [PMID 1328869]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 7708702]
AWJ20_4449	DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity stimulated by RPA and Sgs1p-Top2p-Rmi1p; involved in telomere stability and regulation of mitotic recombination; GO_component: GO:0031422 - RecQ helicase-Topo III complex [Evidence IPI] [PMID 15889139]; GO_component: GO:0031422 - RecQ helicase-Topo III complex [Evidence IDA] [PMID 15899853]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1324925]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IDA] [PMID 22885009]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IEA,IEA]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IDA] [PMID 1324925]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 22885009]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 17571075]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI,IMP] [PMID 1328869]; GO_process: GO:0000018 - regulation of DNA recombination [Evidence IMP] [PMID 1328869]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 7708702]
AWJ20_4453	D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IDA] [PMID 17869212]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IDA] [PMID 17937657]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0070178 - D-serine metabolic process [Evidence IMP] [PMID 17937657]
AWJ20_4455	eIF3j component of translation initiation factor 3 (eIF3); dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of eIF3; required for processing of 20S pre-rRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IPI] [PMID 11179233]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IPI,ISS] [PMID 11179233]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IPI,ISS] [PMID 11179233]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11560931]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
AWJ20_4458	Mitochondrial transcription elongation factor; DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; promotes RNA folding by stabilizing an early assembly intermediate; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 2535893]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 17081564]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 17081564]; GO_function: GO:0033592 - RNA strand annealing activity [Evidence IDA] [PMID 17081564]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000372 - Group I intron splicing [Evidence IMP] [PMID 15618406]; GO_process: GO:0000373 - Group II intron splicing [Evidence IMP] [PMID 15618406]; GO_process: GO:0000373 - Group II intron splicing [Evidence IDA] [PMID 17081564]; GO_process: GO:0034337 - RNA folding [Evidence IMP] [PMID 21045551]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006392 - transcription elongation from mitochondrial promoter [Evidence IDA,IMP] [PMID 24732805]
AWJ20_4459	Putative RNA binding hypothetical protein; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4460	Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 16421251]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 16421251]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 23335340]; GO_component: GO:0071561 - nucleus-vacuole junction [Evidence IDA] [PMID 23335340]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 21121900]; GO_component: GO:0034271 - phosphatidylinositol 3-kinase complex I [Evidence IDA] [PMID 11157979]; GO_component: GO:0034272 - phosphatidylinositol 3-kinase complex II [Evidence IDA] [PMID 11157979]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 16421251]; GO_function: GO:0016303 - 1-phosphatidylinositol-3-kinase activity [Evidence IEA,IEA]; GO_function: GO:0016303 - 1-phosphatidylinositol-3-kinase activity [Evidence IDA] [PMID 7989323]; GO_function: GO:0016303 - 1-phosphatidylinositol-3-kinase activity [Evidence IDA,IMP] [PMID 8385367]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 7989323]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 21121900]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 7989323]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA,IMP] [PMID 8385367]; GO_process: GO:0036092 - phosphatidylinositol-3-phosphate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0048015 - phosphatidylinositol-mediated signaling [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 23335340]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 7989323]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4461	Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051903 - S-(hydroxymethyl)glutathione dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0051903 - S-(hydroxymethyl)glutathione dehydrogenase activity [Evidence IDA] [PMID 8483449]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IMP] [PMID 12499363]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 8483449]; GO_function: GO:0033833 - hydroxymethylfurfural reductase (NADH) activity [Evidence IMP] [PMID 16652391]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006069 - ethanol oxidation [Evidence IEA]; GO_process: GO:0046294 - formaldehyde catabolic process [Evidence IDA] [PMID 8483449]; GO_process: GO:0033859 - furaldehyde metabolic process [Evidence IMP] [PMID 16652391]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4463	Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies; also localized to lipid droplets; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14690591]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004140 - dephospho-CoA kinase activity [Evidence IEA,IEA]; GO_function: GO:0004140 - dephospho-CoA kinase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0004140 - dephospho-CoA kinase activity [Evidence ISS] [PMID 14690591]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 10592175]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4464	2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008677 - 2-dehydropantoate 2-reductase activity [Evidence IEA,IEA]; GO_function: GO:0008677 - 2-dehydropantoate 2-reductase activity [Evidence ISS] [PMID 11154694]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence ISS] [PMID 11154694]
AWJ20_4465	Ribosomal protein lysine methyltransferase; responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IDA] [PMID 17005568]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0018026 - peptidyl-lysine monomethylation [Evidence IDA] [PMID 17005568]; GO_process: GO:0018023 - peptidyl-lysine trimethylation [Evidence IMP] [PMID 17005568]
AWJ20_4467	E3 ubiquitin ligase (N-recognin); heterodimerizes with Rad6p to ubiquitinate substrates in the N-end rule pathway; role in endoplasmic reticulum-associated protein degradation (ERAD) in the absence of canonical ER membrane ligases or after stress; major role in targeting misfolded cytosolic proteins for degradation; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS); GO_component: GO:0005737 - cytoplasm [Evidence IGI,IMP] [PMID 20080635]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IPI] [PMID 10688918]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 10581257]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 23988329]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20080635]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22670231]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 10581257]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 2209542]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0090089 - regulation of dipeptide transport [Evidence IMP] [PMID 9427760]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:0071596 - ubiquitin-dependent protein catabolic process via the N-end rule pathway [Evidence IMP] [PMID 2209542]
AWJ20_4468	Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11359929]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA,IMP,ISS] [PMID 11359929]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IDA] [PMID 782885]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IDA,ISS] [PMID 8509419]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation [Evidence IDA] [PMID 782885]; GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation [Evidence IDA] [PMID 8509419]
AWJ20_4473	Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex, Kti11p, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell cycle; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 13680156]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18466297]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI,IMP] [PMID 13680156]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IGI,IMP] [PMID 13680156]; GO_process: GO:0007017 - microtubule-based process [Evidence IGI,ISS] [PMID 8070652]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
AWJ20_4476	Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IEA,IEA]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IMP,ISS] [PMID 11031268]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IMP] [PMID 3888627]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11031268]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IEA,IEA]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IEP,IMP,ISS] [PMID 11031268]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 3888627]; GO_process: GO:0006540 - glutamate decarboxylation to succinate [Evidence IGI,IMP,ISS] [PMID 11031268]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4477	High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4479	Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 2843500]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004802 - transketolase activity [Evidence IEA,IEA]; GO_function: GO:0004802 - transketolase activity [Evidence IMP,ISS] [PMID 8226984]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IMP] [PMID 8299150]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence TAS] [PMID 8534086]
AWJ20_4480	Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0005801 - cis-Golgi network [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence TAS] [PMID 12077121]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10512869]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20065092]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20065092]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000301 - retrograde transport, vesicle recycling within Golgi [Evidence IMP] [PMID 11703943]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4481	Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004665 - prephenate dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0008977 - prephenate dehydrogenase activity [Evidence IEA]; GO_function: GO:0008977 - prephenate dehydrogenase activity [Evidence ISS] [PMID 2697638]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006571 - tyrosine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006570 - tyrosine metabolic process [Evidence NAS] [PMID 11752249]
AWJ20_4482	Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10864042]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 23180764]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence ISS] [PMID 10864042]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence IMP] [PMID 23180764]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IMP] [PMID 23180764]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI,IMP] [PMID 10864042]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IGI] [PMID 23180764]
AWJ20_4488	Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034457 - Mpp10 complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12242301]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IPI] [PMID 11864606]; GO_function: GO:0043047 - single-stranded telomeric DNA binding [Evidence IDA] [PMID 17803460]; GO_function: GO:0030515 - snoRNA binding [Evidence IDA] [PMID 15489263]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4489	ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14763985]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005844 - polysome [Evidence TAS] [PMID 10098411]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence TAS] [PMID 10322435]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence TAS] [PMID 10322435]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence TAS] [PMID 10098411]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0043024 - ribosomal small subunit binding [Evidence IDA] [PMID 23801788]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 23390378]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 16157874]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 16777600]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 16285926]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12769863]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA,IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence TAS] [PMID 10098411]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP,IPI] [PMID 18676617]; GO_process: GO:0006449 - regulation of translational termination [Evidence TAS] [PMID 10098411]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 15388879]
AWJ20_4492	GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10444589]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IBA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0031235 - intrinsic component of the cytoplasmic side of the plasma membrane [Evidence IBA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA,IEA]; GO_function: GO:0005099 - Ras GTPase activator activity [Evidence IBA]; GO_function: GO:0005099 - Ras GTPase activator activity [Evidence IDA] [PMID 8371782]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 2065354]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 22558355]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 2065354]; GO_process: GO:0007163 - establishment or maintenance of cell polarity [Evidence IMP] [PMID 23783029]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 15645503]; GO_process: GO:0036267 - invasive filamentous growth [Evidence IMP] [PMID 23783029]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IMP] [PMID 22558355]; GO_process: GO:0046580 - negative regulation of Ras protein signal transduction [Evidence IBA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0032320 - positive regulation of Ras GTPase activity [Evidence IBA]; GO_process: GO:0051056 - regulation of small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_4495	Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; GO_component: GO:0097047 - DNA replication termination region [Evidence IPI] [PMID 20797631]; GO_component: GO:0009330 - DNA topoisomerase complex (ATP-hydrolyzing) [Evidence IBA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 6088500]; GO_component: GO:0000795 - synaptonemal complex [Evidence IDA] [PMID 1315786]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IDA] [PMID 6088500]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IDA] [PMID 6323017]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IBA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA,IEA]; GO_process: GO:0006259 - DNA metabolic process [Evidence IEA]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 2549254]; GO_process: GO:0006265 - DNA topological change [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 6088500]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IMP] [PMID 24062159]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IMP] [PMID 9199287]; GO_process: GO:0031055 - chromatin remodeling at centromere [Evidence IMP] [PMID 18701701]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IMP] [PMID 16651657]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 2156624]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 2902925]; GO_process: GO:0097046 - replication fork progression beyond termination site [Evidence IMP] [PMID 20797631]; GO_process: GO:0000712 - resolution of meiotic recombination intermediates [Evidence IBA]; GO_process: GO:0000819 - sister chromatid segregation [Evidence IBA]
AWJ20_4496	Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; GO_component: GO:0097047 - DNA replication termination region [Evidence IPI] [PMID 20797631]; GO_component: GO:0009330 - DNA topoisomerase complex (ATP-hydrolyzing) [Evidence IBA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 6088500]; GO_component: GO:0000795 - synaptonemal complex [Evidence IDA] [PMID 1315786]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IDA] [PMID 6088500]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IDA] [PMID 6323017]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IBA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA,IEA]; GO_process: GO:0006259 - DNA metabolic process [Evidence IEA]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 2549254]; GO_process: GO:0006265 - DNA topological change [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 6088500]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IMP] [PMID 24062159]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IMP] [PMID 9199287]; GO_process: GO:0031055 - chromatin remodeling at centromere [Evidence IMP] [PMID 18701701]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IMP] [PMID 16651657]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 2156624]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 2902925]; GO_process: GO:0097046 - replication fork progression beyond termination site [Evidence IMP] [PMID 20797631]; GO_process: GO:0000712 - resolution of meiotic recombination intermediates [Evidence IBA]; GO_process: GO:0000819 - sister chromatid segregation [Evidence IBA]
AWJ20_4499	Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18667581]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 18667581]; GO_process: GO:0061416 - regulation of transcription from RNA polymerase II promoter in response to salt stress [Evidence IMP] [PMID 18667581]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4500	Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo; GO_component: GO:0030126 - COPI vesicle coat [Evidence IEA]; GO_component: GO:0030126 - COPI vesicle coat [Evidence IDA] [PMID 1461285]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 17101773]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 1461285]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8001155]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
AWJ20_4502	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_4503	Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IDA] [PMID 12401799]; GO_function: GO:0004371 - glycerone kinase activity [Evidence ISS] [PMID 9038161]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0050354 - triokinase activity [Evidence IEA]; GO_process: GO:0019588 - anaerobic glycerol catabolic process [Evidence IEA]; GO_process: GO:0097237 - cellular response to toxic substance [Evidence IMP] [PMID 12401799]; GO_process: GO:0019563 - glycerol catabolic process [Evidence ISS] [PMID 9038161]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4507	Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
AWJ20_4508	17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 10610776]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 11720284]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA,IEA]
AWJ20_4509	Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9288922]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA,IMP] [PMID 9288922]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IDA] [PMID 1859361]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IMP] [PMID 9288922]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 15780654]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 9288922]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]
AWJ20_4510	Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9288922]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA,IMP] [PMID 9288922]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IDA] [PMID 1859361]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IMP] [PMID 9288922]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 15780654]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 9288922]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]
AWJ20_4514	Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10233162]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 11781566]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 17952059]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10233162]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18417610]; GO_component: GO:0042597 - periplasmic space [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IDA] [PMID 15620357]; GO_function: GO:0004707 - MAP kinase activity [Evidence IDA] [PMID 8384702]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000165 - MAPK cascade [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0007050 - cell cycle arrest [Evidence IMP] [PMID 10049917]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000746 - conjugation [Evidence IEA]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10652102]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 15620357]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 8001818]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0043409 - negative regulation of MAPK cascade [Evidence IPI] [PMID 16424299]; GO_process: GO:0010526 - negative regulation of transposition, RNA-mediated [Evidence IMP] [PMID 9566871]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IDA] [PMID 15620357]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IDA] [PMID 8384702]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0046827 - positive regulation of protein export from nucleus [Evidence IMP] [PMID 22588722]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 22588722]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8384702]
AWJ20_4515	Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]
AWJ20_4518	Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 11511347]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 11511347]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IDA] [PMID 11553724]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11511347]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9606209]; GO_function: GO:0008017 - microtubule binding [Evidence IMP] [PMID 11553724]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9606209]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IGI] [PMID 11756468]
AWJ20_4519	Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_4520	ATP-binding hypothetical protein; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 14997573]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4522	Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11274162]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11274162]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 11274162]
AWJ20_4524	Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0000228 - nuclear chromosome [Evidence IPI] [PMID 12944972]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI,IMP] [PMID 16219777]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 16137625]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IMP,IPI] [PMID 12944972]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IMP] [PMID 18321795]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 17483413]; GO_process: GO:0008156 - negative regulation of DNA replication [Evidence IEA]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16103218]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16418273]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 17652453]; GO_process: GO:0048478 - replication fork protection [Evidence IMP] [PMID 16418273]; GO_process: GO:0048478 - replication fork protection [Evidence IMP] [PMID 18632578]
AWJ20_4525	Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0000228 - nuclear chromosome [Evidence IPI] [PMID 12944972]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI,IMP] [PMID 16219777]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 16137625]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IMP,IPI] [PMID 12944972]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IMP] [PMID 18321795]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 17483413]; GO_process: GO:0008156 - negative regulation of DNA replication [Evidence IEA]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16103218]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16418273]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 17652453]; GO_process: GO:0048478 - replication fork protection [Evidence IMP] [PMID 16418273]; GO_process: GO:0048478 - replication fork protection [Evidence IMP] [PMID 18632578]
AWJ20_4526	5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0046570 - methylthioribulose 1-phosphate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0046570 - methylthioribulose 1-phosphate dehydratase activity [Evidence IMP] [PMID 18625006]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0019284 - L-methionine biosynthetic process from S-adenosylmethionine [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]
AWJ20_4527	5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0046570 - methylthioribulose 1-phosphate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0046570 - methylthioribulose 1-phosphate dehydratase activity [Evidence IMP] [PMID 18625006]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0019284 - L-methionine biosynthetic process from S-adenosylmethionine [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]
AWJ20_4528	E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12876294]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 23103252]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 19531475]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 12535539]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IGI] [PMID 16783014]; GO_process: GO:0010390 - histone monoubiquitination [Evidence IMP] [PMID 12535538]; GO_process: GO:0010390 - histone monoubiquitination [Evidence IMP] [PMID 12535539]; GO_process: GO:0016574 - histone ubiquitination [Evidence IMP] [PMID 23103252]; GO_process: GO:0031573 - intra-S DNA damage checkpoint [Evidence IMP] [PMID 15632126]; GO_process: GO:0042138 - meiotic DNA double-strand break formation [Evidence IMP] [PMID 15280549]; GO_process: GO:0031571 - mitotic G1 DNA damage checkpoint [Evidence IMP] [PMID 16166626]; GO_process: GO:0031571 - mitotic G1 DNA damage checkpoint [Evidence IMP] [PMID 16783014]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 23103252]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IGI] [PMID 23390378]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI] [PMID 15632065]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IPI] [PMID 19531475]
AWJ20_4529	Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23509072]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16140254]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005342 - organic acid transmembrane transporter activity [Evidence IGI,ISS] [PMID 16140254]; GO_process: GO:0006839 - mitochondrial transport [Evidence IGI] [PMID 16140254]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4530	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 17761172]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9391108]; GO_function: GO:0004888 - transmembrane signaling receptor activity [Evidence IGI,ISS] [PMID 10430578]; GO_process: GO:0007266 - Rho protein signal transduction [Evidence IMP] [PMID 10348843]; GO_process: GO:0007266 - Rho protein signal transduction [Evidence IMP] [PMID 10508863]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 10508863]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 10508863]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 24326069]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 10348843]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 24326069]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 10348843]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 10508863]; GO_process: GO:0006970 - response to osmotic stress [Evidence IGI] [PMID 14871941]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_4531	Phosphatidylserine synthase; functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 2002005]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 6274497]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 3005242]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_function: GO:0003882 - CDP-diacylglycerol-serine O-phosphatidyltransferase activity [Evidence IEA]; GO_function: GO:0003882 - CDP-diacylglycerol-serine O-phosphatidyltransferase activity [Evidence IDA] [PMID 6088519]; GO_function: GO:0003882 - CDP-diacylglycerol-serine O-phosphatidyltransferase activity [Evidence IMP] [PMID 6988386]; GO_function: GO:0016780 - phosphotransferase activity, for other substituted phosphate groups [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0006659 - phosphatidylserine biosynthetic process [Evidence IDA] [PMID 6088519]; GO_process: GO:0006659 - phosphatidylserine biosynthetic process [Evidence IMP] [PMID 6988386]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
AWJ20_4532	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 15689497]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0032126 - eisosome [Evidence IDA] [PMID 21451250]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15372071]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15689497]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17101780]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 15689497]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 21119626]; GO_function: GO:0046625 - sphingolipid binding [Evidence IDA] [PMID 21119626]; GO_process: GO:0031929 - TOR signaling [Evidence IPI] [PMID 15689497]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 15372071]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 15689497]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IGI] [PMID 15689497]; GO_process: GO:0070941 - eisosome assembly [Evidence IGI] [PMID 21451250]; GO_process: GO:0016197 - endosomal transport [Evidence IGI] [PMID 21451250]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IPI] [PMID 15689497]; GO_process: GO:0001558 - regulation of cell growth [Evidence IGI,IPI] [PMID 15689497]
AWJ20_4533	Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 11278778]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004377 - GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IGI] [PMID 11278778]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IDA] [PMID 16878994]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006490 - oligosaccharide-lipid intermediate biosynthetic process [Evidence IDA] [PMID 16878994]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IGI] [PMID 11278778]
AWJ20_4534	Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11434459]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 11434459]; GO_function: GO:0019207 - kinase regulator activity [Evidence IDA] [PMID 11404483]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 11404483]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence TAS] [PMID 11404483]
AWJ20_4535	hypothetical protein; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4536	ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 8146662]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 8276800]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IBA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 8146662]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 8276800]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0070361 - mitochondrial light strand promoter anti-sense binding [Evidence IBA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IBA]; GO_function: GO:0003727 - single-stranded RNA binding [Evidence IBA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IBA,IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IGI] [PMID 8810243]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IEA,IEA]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 16336126]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IGI,IMP] [PMID 7957078]; GO_process: GO:0007005 - mitochondrion organization [Evidence IBA]; GO_process: GO:0070407 - oxidation-dependent protein catabolic process [Evidence IBA,IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0051260 - protein homooligomerization [Evidence IBA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0090296 - regulation of mitochondrial DNA replication [Evidence IEA]; GO_process: GO:0001666 - response to hypoxia [Evidence IBA]
AWJ20_4537	G protein gamma subunit; forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8995254]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IEA]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IMP] [PMID 2105453]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IDA] [PMID 8995254]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8995254]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA,IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP] [PMID 2107073]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0031684 - heterotrimeric G-protein complex cycle [Evidence IMP] [PMID 2107073]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 3151178]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_4538	Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004066 - asparagine synthase (glutamine-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0004066 - asparagine synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 6105958]; GO_function: GO:0004066 - asparagine synthase (glutamine-hydrolyzing) activity [Evidence ISS] [PMID 8951815]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0070981 - L-asparagine biosynthetic process [Evidence IEA]; GO_process: GO:0006529 - asparagine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006529 - asparagine biosynthetic process [Evidence IGI] [PMID 8951815]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4541	Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0042623 - ATPase activity, coupled [Evidence IDA] [PMID 12235160]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 10564510]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IDA] [PMID 10564510]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 9371781]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 18268103]; GO_process: GO:0032212 - positive regulation of telomere maintenance via telomerase [Evidence IDA,IMP,IPI] [PMID 17954556]; GO_process: GO:0043248 - proteasome assembly [Evidence IDA,IGI,IMP] [PMID 12853471]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IMP] [PMID 9371781]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IPI] [PMID 12526792]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 16487343]; GO_process: GO:0006950 - response to stress [Evidence IEA,IEA]
AWJ20_4543	Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 23438601]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP,IPI] [PMID 23438601]
AWJ20_4544	P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 17430889]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4545	Rab family GTPase; Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; resides temporarily at the Golgi, dissociates into cytosol upon arrival of the Rab GTPaseYpt32p, which also functions in the late Golgi; Golgi-localized form is bound to GTP, while cytosolic form is GDP-bound; homolog of the mammalian Rab6; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 24194547]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 24924636]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 24924636]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 9433126]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 10990452]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IMP] [PMID 11160819]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4547	Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress; GO_component: GO:0005946 - alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [Evidence IGI,IMP,IPI] [PMID 9837904]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004805 - trehalose-phosphatase activity [Evidence IEA]; GO_function: GO:0004805 - trehalose-phosphatase activity [Evidence IMP] [PMID 8444170]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 8203161]; GO_process: GO:0034605 - cellular response to heat [Evidence IDA] [PMID 8444170]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IMP] [PMID 8203161]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IMP] [PMID 8444170]
AWJ20_4548	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 20581295]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0001128 - RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IPI] [PMID 10906145]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 17603098]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 10906145]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7899074]; GO_process: GO:1901717 - positive regulation of gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:1901714 - positive regulation of urea catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_4549	Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IDA,ISS] [PMID 8063832]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12909721]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12912927]; GO_component: GO:0031389 - Rad17 RFC-like complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 12604797]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 8995429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1346062]; GO_process: GO:0006298 - mismatch repair [Evidence TAS] [PMID 10072354]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IPI] [PMID 11389843]
AWJ20_4551	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enahnces invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication; GO_component: GO:0061576 - acyl-CoA ceramide synthase complex [Evidence IDA] [PMID 15692566]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IEA]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IMP] [PMID 11387200]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IMP] [PMID 11694577]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IDA] [PMID 15692566]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IMP] [PMID 11694577]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IDA] [PMID 15692566]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IEP,IMP] [PMID 8195187]
AWJ20_4553	Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11274162]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20118605]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015183 - L-aspartate transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0005313 - L-glutamate transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11274162]; GO_process: GO:0032974 - amino acid transmembrane export from vacuole [Evidence IMP] [PMID 11274162]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 11274162]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4554	Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16043506]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16043506]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 16128814]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15686447]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 16128814]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 16043506]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4556	Splicing factor that reanneals snRNPs during spliceosome recycling; reanneals U4 and U6 snRNPs; GO_component: GO:0005688 - U6 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IDA] [PMID 20181740]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0017069 - snRNA binding [Evidence IPI] [PMID 16410014]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IMP] [PMID 10022888]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IDA] [PMID 9452384]
AWJ20_4557	Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20620957]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IDA] [PMID 12408819]; GO_function: GO:0032947 - protein complex scaffold [Evidence IDA] [PMID 20620957]; GO_process: GO:0043248 - proteasome assembly [Evidence IDA] [PMID 20620957]
AWJ20_4558	Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]
AWJ20_4559	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000137 - Golgi cis cisterna [Evidence IDA] [PMID 9430634]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 9434768]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA,IMP] [PMID 9430634]
AWJ20_4560	Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 8194532]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 8248176]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0000151 - ubiquitin ligase complex [Evidence IEA]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 8248176]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 12627222]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IMP] [PMID 12970570]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
AWJ20_4564	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4565	Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IEA]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IMP] [PMID 10900271]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IMP] [PMID 15169871]; GO_function: GO:0004725 - protein tyrosine phosphatase activity [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0035335 - peptidyl-tyrosine dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 10900271]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IGI,IMP] [PMID 15169871]
AWJ20_4566	Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISS] [PMID 1423607]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 15623581]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP,IPI] [PMID 10564255]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 15623581]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 10564255]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 15623581]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4568	Protein component of the small (40S) ribosomal subunit; has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 3533916]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 385049]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 16738661]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IDA] [PMID 11561734]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 3533916]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 385049]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 16246728]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IGI] [PMID 22570489]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4569	Poly(A) binding protein; part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15630021]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15769879]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15630021]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15769879]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 8631901]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA,IMP] [PMID 9193001]; GO_function: GO:0008428 - ribonuclease inhibitor activity [Evidence IDA] [PMID 11889048]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IDA,IMP] [PMID 17766253]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA,IMP] [PMID 10357826]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4570	Non-essential hypothetical protein; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 9200815]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]
AWJ20_4571	Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11489916]; GO_component: GO:0015629 - actin cytoskeleton [Evidence IPI] [PMID 10992286]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IEA]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IDA,IMP] [PMID 23071111]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IDA] [PMID 23335564]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IPI] [PMID 10992286]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 23071111]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
AWJ20_4572	Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 795470]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0005471 - ATP:ADP antiporter activity [Evidence IDA] [PMID 8476415]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015866 - ADP transport [Evidence IDA] [PMID 8476415]; GO_process: GO:0015867 - ATP transport [Evidence IDA] [PMID 8476415]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 2167309]; GO_process: GO:0009061 - anaerobic respiration [Evidence IGI] [PMID 1915842]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17822411]; GO_process: GO:0015886 - heme transport [Evidence IMP,IPI] [PMID 18728780]; GO_process: GO:0006839 - mitochondrial transport [Evidence IMP] [PMID 2167309]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 8476415]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_4574	Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0005745 - m-AAA complex [Evidence IDA] [PMID 8681382]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0097002 - mitochondrial inner boundary membrane [Evidence IDA] [PMID 19019989]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7929327]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 19748354]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 19748354]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7929327]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IMP] [PMID 8681382]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 19748354]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 8681382]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence TAS] [PMID 12417197]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IMP] [PMID 8681382]; GO_process: GO:0006465 - signal peptide processing [Evidence IMP] [PMID 12417197]
AWJ20_4576	similar to hypothetical protein; allele of CaO19.13270
AWJ20_4578	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 8626693]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 8626693]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 8626693]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 9973221]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 14627813]; GO_process: GO:0000461 - endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 14627813]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IGI] [PMID 16246728]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IEA]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 8626693]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
AWJ20_4579	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IBA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0006364 - rRNA processing [Evidence IBA,IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IBA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4580	Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; localizes to cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at nuclear periphery; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 18462190]; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005621 - cellular bud scar [Evidence IDA] [PMID 19793924]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 19793924]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 10716729]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 19541632]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 1824714]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19793924]; GO_component: GO:0000936 - primary cell septum [Evidence IDA] [PMID 19793924]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 10809732]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 15355340]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 17397106]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006342 - chromatin silencing [Evidence IMP,IPI] [PMID 19541632]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 15645503]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16986442]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 9515908]
AWJ20_4588	Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IC] [PMID 9643541]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 19767828]
AWJ20_4589	ATP binding cassette protein; cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 19806183]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence ISS] [PMID 12110682]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 12110682]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence ISS] [PMID 12110682]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4592	Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog, MMT1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9353309]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9353309]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IGI,IMP] [PMID 9353309]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4594	Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0070211 - Snt2C complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 23878396]
AWJ20_4595	DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 8444852]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8444852]; GO_process: GO:0006281 - DNA repair [Evidence IDA,IMP] [PMID 2111448]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_4596	Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 10497163]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IDA,IMP,ISS] [PMID 10497163]; GO_function: GO:0004620 - phospholipase activity [Evidence IEA]; GO_process: GO:0006650 - glycerophospholipid metabolic process [Evidence IDA,IGI,IMP] [PMID 10497163]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]
AWJ20_4597	Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 15608614]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 15326197]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070096 - mitochondrial outer membrane translocase complex assembly [Evidence IMP] [PMID 15608614]; GO_process: GO:0070096 - mitochondrial outer membrane translocase complex assembly [Evidence IMP] [PMID 17974559]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IMP] [PMID 21825073]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IMP] [PMID 21825074]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4598	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8858151]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9575221]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 14761951]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA,IPI] [PMID 8858151]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 9575221]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14761951]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9575221]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 8858151]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 9575221]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 8858151]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IDA] [PMID 8858151]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 10982821]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 8858151]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 9575221]
AWJ20_4599	Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10477278]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042392 - sphingosine-1-phosphate phosphatase activity [Evidence TAS] [PMID 11278643]; GO_function: GO:0042392 - sphingosine-1-phosphate phosphatase activity [Evidence IDA] [PMID 9353337]; GO_process: GO:0019722 - calcium-mediated signaling [Evidence IMP] [PMID 11278643]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence TAS] [PMID 10563329]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
AWJ20_4600	GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p); GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IDA] [PMID 8602515]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 1918143]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8195291]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8195291]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8195291]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12660244]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 15596542]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11591390]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 7962098]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 15596542]; GO_process: GO:0031532 - actin cytoskeleton reorganization [Evidence IGI,IPI] [PMID 8947028]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI,IMP] [PMID 8195291]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0090037 - positive regulation of protein kinase C signaling [Evidence IDA,IMP] [PMID 8621575]; GO_process: GO:0090037 - positive regulation of protein kinase C signaling [Evidence IGI,IPI] [PMID 8846785]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 8602514]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 8602515]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 8662910]; GO_process: GO:0060178 - regulation of exocyst localization [Evidence IMP] [PMID 11283608]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 8621575]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 10893184]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IDA] [PMID 8621575]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IGI] [PMID 8846785]
AWJ20_4602	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004028 - 3-chloroallyl aldehyde dehydrogenase activity [Evidence ISS] [PMID 16407407]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0047770 - carboxylate reductase activity [Evidence IMP] [PMID 22633490]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence IEA]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence IC] [PMID 16407407]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence IMP] [PMID 22633490]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4603	Splicing factor; component of the U4/U6-U5 snRNP complex; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IEA]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000387 - spliceosomal snRNP assembly [Evidence IDA,IMP] [PMID 9199293]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IEA]
AWJ20_4606	allele of CaO19.8194
AWJ20_4608	Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003962 - cystathionine gamma-synthase activity [Evidence IEA]; GO_function: GO:0003962 - cystathionine gamma-synthase activity [Evidence IMP] [PMID 10821189]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence IMP] [PMID 10821189]; GO_process: GO:0019346 - transsulfuration [Evidence IMP] [PMID 10821189]
AWJ20_4610	Allantoicase; converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004037 - allantoicase activity [Evidence IEA,IEA]; GO_function: GO:0004037 - allantoicase activity [Evidence ISS] [PMID 1916277]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IEA,IEA]; GO_process: GO:0000256 - allantoin catabolic process [Evidence IMP] [PMID 1916277]; GO_process: GO:0006144 - purine nucleobase metabolic process [Evidence IEA]
AWJ20_4611	Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8864657]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IDA] [PMID 12090241]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IMP] [PMID 1714453]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IMP] [PMID 8439291]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IDA] [PMID 8910350]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 8905927]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0035977 - protein deglycosylation involved in glycoprotein catabolic process [Evidence IMP] [PMID 9732283]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_4614	DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence TAS] [PMID 9745046]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence TAS] [PMID 9745046]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IDA] [PMID 12235149]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA,IMP] [PMID 10438542]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA] [PMID 15342630]
AWJ20_4616	Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IGI,ISA] [PMID 8618900]; GO_function: GO:0008235 - metalloexopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0070084 - protein initiator methionine removal [Evidence IEA]; GO_process: GO:0035551 - protein initiator methionine removal involved in protein maturation [Evidence IMP] [PMID 11811952]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_4617	Maltose permease; high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0005352 - alpha-glucoside:proton symporter activity [Evidence ISS] [PMID 18179544]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0000017 - alpha-glucoside transport [Evidence ISS] [PMID 18179544]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0000023 - maltose metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_4621	Transcription factor that regulates acetate production; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 16785442]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IMP] [PMID 23240040]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4625	3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004618 - phosphoglycerate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004618 - phosphoglycerate kinase activity [Evidence IDA] [PMID 6254992]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 400791]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 400791]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4626	GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication; GO_component: GO:0005798 - Golgi-associated vesicle [Evidence IDA] [PMID 15331637]; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15331637]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 15331637]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12189143]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15331637]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15331637]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IGI,IPI,ISS] [PMID 12189143]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IGI,IPI] [PMID 15802519]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 15802519]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 12189143]
AWJ20_4627	Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval; GO_component: GO:0005768 - endosome [Evidence IPI] [PMID 9700157]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030906 - retromer complex, inner shell [Evidence IPI] [PMID 9700157]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4628	Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12700234]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 8132653]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IMP] [PMID 8132653]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IMP] [PMID 9398220]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006563 - L-serine metabolic process [Evidence IEA]; GO_process: GO:0006544 - glycine metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IMP] [PMID 8132653]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI,IMP] [PMID 9398220]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
AWJ20_4631	Hsp90 cochaperone; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 12525481]; GO_function: GO:0042030 - ATPase inhibitor activity [Evidence IDA] [PMID 21170051]; GO_function: GO:0030544 - Hsp70 protein binding [Evidence IDA] [PMID 12716905]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 12525481]; GO_function: GO:0051879 - Hsp90 protein binding [Evidence IDA] [PMID 9927435]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_process: GO:0006457 - protein folding [Evidence IGI,IMP] [PMID 8972212]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_4632	Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 22404850]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 22404850]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0003785 - actin monomer binding [Evidence IDA] [PMID 15126500]; GO_function: GO:0004860 - protein kinase inhibitor activity [Evidence IMP] [PMID 15126500]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 22404850]; GO_process: GO:0001933 - negative regulation of protein phosphorylation [Evidence IMP] [PMID 15126500]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]
AWJ20_4633	Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8804409]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 8804409]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15231838]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15231838]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15231838]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8804409]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4634	Essential hypothetical protein; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA]
AWJ20_4637	Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004350 - glutamate-5-semialdehyde dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004350 - glutamate-5-semialdehyde dehydrogenase activity [Evidence IDA] [PMID 12513997]; GO_function: GO:0004350 - glutamate-5-semialdehyde dehydrogenase activity [Evidence IGI] [PMID 2824433]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0055129 - L-proline biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006561 - proline biosynthetic process [Evidence TAS] [PMID 11084050]; GO_process: GO:0006561 - proline biosynthetic process [Evidence IDA] [PMID 12513997]
AWJ20_4638	Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; subject to auto-inhibition by its C-terminal tail; mutations in human homolog ATP8B1 result in liver disease; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 10601336]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 12221123]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 15090616]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI] [PMID 15090616]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IMP] [PMID 15249668]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 16452632]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IMP] [PMID 8633245]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 24272750]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 12631737]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 16195350]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 15249668]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 16452632]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 10601336]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 8247005]
AWJ20_4639	Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; subject to auto-inhibition by its C-terminal tail; mutations in human homolog ATP8B1 result in liver disease; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 10601336]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 12221123]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 15090616]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI] [PMID 15090616]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IMP] [PMID 15249668]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 16452632]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IMP] [PMID 8633245]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 24272750]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 12631737]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 16195350]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 15249668]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 16452632]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0006892 - post-Golgi vesicle-mediated transport [Evidence IGI,IMP] [PMID 10601336]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 8247005]
AWJ20_4640	Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 10037752]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 16034811]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 10037752]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 8991513]
AWJ20_4641	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
AWJ20_4642	Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8016655]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA,IMP] [PMID 8159677]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 3143101]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IPI] [PMID 11865042]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IMP,IPI] [PMID 14580348]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 8016655]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 10198436]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 14580348]; GO_process: GO:0044109 - cellular alcohol catabolic process [Evidence IMP] [PMID 1339306]; GO_process: GO:0031496 - positive regulation of mating type switching [Evidence IMP] [PMID 6436497]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 1339306]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3542227]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 8016655]; GO_process: GO:0061412 - positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation [Evidence IMP] [PMID 10549298]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0005987 - sucrose catabolic process [Evidence IMP] [PMID 1339306]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4644	Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 12707309]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007031 - peroxisome organization [Evidence IEA]; GO_process: GO:0007031 - peroxisome organization [Evidence IDA,IGI,IMP] [PMID 12707309]
AWJ20_4645	Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004642 - phosphoribosylformylglycinamidine synthase activity [Evidence IEA,IEA]; GO_function: GO:0004642 - phosphoribosylformylglycinamidine synthase activity [Evidence IMP] [PMID 9331966]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IC] [PMID 9331966]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 1743513]
AWJ20_4647	Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 16569665]; GO_function: GO:0003785 - actin monomer binding [Evidence IDA] [PMID 9700161]; GO_process: GO:0044396 - actin cortical patch organization [Evidence IMP] [PMID 16569665]; GO_process: GO:0030042 - actin filament depolymerization [Evidence IDA] [PMID 16569665]; GO_process: GO:0007015 - actin filament organization [Evidence IDA,IMP] [PMID 16569665]; GO_process: GO:0051014 - actin filament severing [Evidence IDA,IMP] [PMID 16569665]; GO_process: GO:0030837 - negative regulation of actin filament polymerization [Evidence IEA]; GO_process: GO:0042989 - sequestering of actin monomers [Evidence IDA] [PMID 9700161]
AWJ20_4648	Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 7908717]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005469 - succinate:fumarate antiporter activity [Evidence IDA] [PMID 9395087]; GO_process: GO:0015741 - fumarate transport [Evidence IDA] [PMID 9395087]; GO_process: GO:0015744 - succinate transport [Evidence IDA] [PMID 9395087]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4649	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 11931764]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_function: GO:0003682 - chromatin binding [Evidence IPI] [PMID 11931764]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA,IDA] [PMID 12183366]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IDA] [PMID 11931764]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 11931764]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 11931764]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11931764]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
AWJ20_4653	Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 22310663]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 22342701]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 22405070]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22310663]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22342701]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22405070]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IGI] [PMID 22310663]; GO_process: GO:0097250 - mitochondrial respiratory chain supercomplex assembly [Evidence IMP] [PMID 22342701]; GO_process: GO:0097250 - mitochondrial respiratory chain supercomplex assembly [Evidence IMP] [PMID 22405070]
AWJ20_4654	Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004385 - guanylate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004385 - guanylate kinase activity [Evidence IDA] [PMID 1334480]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046037 - GMP metabolic process [Evidence TAS] [PMID 11035032]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006163 - purine nucleotide metabolic process [Evidence IEA]
AWJ20_4656	Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12869188]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 10848624]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12869188]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 17803462]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA] [PMID 10848624]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IGI] [PMID 10848624]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI] [PMID 16126894]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0045717 - negative regulation of fatty acid biosynthetic process [Evidence IDA,IGI,IMP] [PMID 17803462]; GO_process: GO:1901352 - negative regulation of phosphatidylglycerol biosynthetic process [Evidence IGI] [PMID 12869188]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IGI] [PMID 16262726]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 10848624]; GO_process: GO:2001247 - positive regulation of phosphatidylcholine biosynthetic process [Evidence IGI] [PMID 12869188]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4658	Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16204239]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0032217 - riboflavin transporter activity [Evidence IGI] [PMID 16204239]; GO_process: GO:0032218 - riboflavin transport [Evidence IGI] [PMID 16204239]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4659	Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16204239]; GO_function: GO:0008028 - monocarboxylic acid transmembrane transporter activity [Evidence IGI,IMP] [PMID 11536335]; GO_function: GO:0032217 - riboflavin transporter activity [Evidence IGI] [PMID 16204239]; GO_process: GO:0032218 - riboflavin transport [Evidence IGI] [PMID 16204239]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4660	Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4662	Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 1535043]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8319300]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEP] [PMID 10206703]; GO_process: GO:0071361 - cellular response to ethanol [Evidence IEP] [PMID 10206703]; GO_process: GO:0034605 - cellular response to heat [Evidence IEP] [PMID 10206703]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IEP] [PMID 10206703]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IEP] [PMID 10206703]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0032780 - negative regulation of ATPase activity [Evidence IMP] [PMID 9250391]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_4663	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10471279]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19029246]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IDA] [PMID 14500818]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000703 - oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [Evidence IDA,ISS] [PMID 9020769]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IDA] [PMID 14500818]; GO_process: GO:0006285 - base-excision repair, AP site formation [Evidence IDA] [PMID 9826748]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4665	Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; deletion causes mutator phenotype; protein abundance increases and forms cytoplasmic foci during DNA replication stress; chaperone activity is essential for growth under zinc deficiency; required for telomere length maintenance; TSA1 has a paralog, TSA2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10681558]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8344960]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18271751]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 18271751]; GO_function: GO:0016209 - antioxidant activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004601 - peroxidase activity [Evidence IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IEA,IEA]; GO_function: GO:0051920 - peroxiredoxin activity [Evidence IDA] [PMID 17210445]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 18271751]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP] [PMID 7961686]; GO_function: GO:0008379 - thioredoxin peroxidase activity [Evidence IDA,IMP] [PMID 9799566]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 16251355]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IGI] [PMID 19851444]; GO_process: GO:0042262 - DNA protection [Evidence IMP] [PMID 19543365]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 8344960]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IMP] [PMID 9799566]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 18271751]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IDA,IMP] [PMID 8344960]; GO_process: GO:0061077 - chaperone-mediated protein folding [Evidence IMP] [PMID 24022485]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 16251355]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 20729566]; GO_process: GO:0033194 - response to hydroperoxide [Evidence IMP] [PMID 15210711]
AWJ20_4666	Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock; GO_component: GO:0070772 - PAS complex [Evidence IDA,IPI] [PMID 19037259]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 9372916]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 9372916]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IDA] [PMID 19037259]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033674 - positive regulation of kinase activity [Evidence IGI] [PMID 11950935]; GO_process: GO:0010513 - positive regulation of phosphatidylinositol biosynthetic process [Evidence IGI] [PMID 11950935]
AWJ20_4669	Negative regulator of WASP-Arp23 complex; involved in endocytic site formation; directly inhibits Las17p stimulation of Arp23 complex-mediated actin assembly in vitro; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11014808]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11014808]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 11014808]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0004857 - enzyme inhibitor activity [Evidence IDA] [PMID 19962315]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence IMP] [PMID 19776351]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IDA] [PMID 19962315]; GO_process: GO:0032185 - septin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 18791237]
AWJ20_4672	Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 17914457]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 17914457]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17914457]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 17914457]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 17914457]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 12455995]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IGI,IPI] [PMID 7498791]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 8227021]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 8300560]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8013906]; GO_process: GO:0035024 - negative regulation of Rho protein signal transduction [Evidence IGI,IMP,IPI] [PMID 17914457]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0031106 - septin ring organization [Evidence IGI] [PMID 14517318]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_4673	Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0016992 - lipoate synthase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0016992 - lipoate synthase activity [Evidence ISA] [PMID 8349643]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016783 - sulfurtransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009107 - lipoate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009249 - protein lipoylation [Evidence IEA]; GO_process: GO:0009249 - protein lipoylation [Evidence IMP] [PMID 19570983]
AWJ20_4675	Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004053 - arginase activity [Evidence IEA,IEA]; GO_function: GO:0004053 - arginase activity [Evidence IMP] [PMID 14582193]; GO_function: GO:0004053 - arginase activity [Evidence IDA] [PMID 2404017]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016813 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IDA] [PMID 1939179]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0090369 - ornithine carbamoyltransferase inhibitor activity [Evidence IDA,IMP] [PMID 12679340]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 1939179]; GO_process: GO:0019547 - arginine catabolic process to ornithine [Evidence IMP] [PMID 14582193]; GO_process: GO:0019547 - arginine catabolic process to ornithine [Evidence IDA] [PMID 2404017]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA,IEA]; GO_process: GO:0090368 - regulation of ornithine metabolic process [Evidence IDA,IMP] [PMID 12679340]; GO_process: GO:0000050 - urea cycle [Evidence IEA]
AWJ20_4676	Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0032041 - NAD-dependent histone deacetylase activity (H3-K14 specific) [Evidence IEA]; GO_function: GO:0097372 - NAD-dependent histone deacetylase activity (H3-K18 specific) [Evidence IEA]; GO_function: GO:0046969 - NAD-dependent histone deacetylase activity (H3-K9 specific) [Evidence IEA]; GO_function: GO:0046970 - NAD-dependent histone deacetylase activity (H4-K16 specific) [Evidence IEA]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IDA] [PMID 10535926]; GO_function: GO:0031078 - histone deacetylase activity (H3-K14 specific) [Evidence IEA]; GO_function: GO:0032129 - histone deacetylase activity (H3-K9 specific) [Evidence IEA]; GO_function: GO:0034739 - histone deacetylase activity (H4-K16 specific) [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0070932 - histone H3 deacetylation [Evidence IEA]; GO_process: GO:0070933 - histone H4 deacetylation [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 10535926]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17706600]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IGI,IPI] [PMID 19823668]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4678	Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 19279007]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0030246 - carbohydrate binding [Evidence IMP,ISS] [PMID 11375935]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IMP] [PMID 19124653]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11254655]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11375935]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006986 - response to unfolded protein [Evidence IEA]
AWJ20_4679	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4681	Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage; GO_component: GO:0000262 - mitochondrial chromosome [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IEA,IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10209025]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA,IMP] [PMID 22948312]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 10209025]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 22027892]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IEA]; GO_process: GO:0000725 - recombinational repair [Evidence IMP] [PMID 22027892]
AWJ20_4684	Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 22342701]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22310663]; GO_component: GO:0097249 - mitochondrial respiratory chain supercomplex [Evidence IDA] [PMID 22342701]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0033617 - mitochondrial respiratory chain complex IV assembly [Evidence IGI] [PMID 22310663]
AWJ20_4685	Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence ISS] [PMID 6353412]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IGI] [PMID 15695360]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 3301847]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IGI] [PMID 15695360]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IDA] [PMID 3301847]; GO_function: GO:0003746 - translation elongation factor activity [Evidence ISS] [PMID 6353412]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI] [PMID 15695360]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI] [PMID 16777356]; GO_process: GO:0070125 - mitochondrial translational elongation [Evidence ISA] [PMID 3905388]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]
AWJ20_4686	Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
AWJ20_4688	Regulatory subunit A of the heterotrimeric PP2A complex; the heterotrimeric protein phosphatase 2A (PP2A) complex also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12388751]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12388751]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12388751]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12388751]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12388751]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IDA] [PMID 17550305]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 12388751]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA,IMP] [PMID 17550305]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IMP] [PMID 9001215]; GO_process: GO:0006417 - regulation of translation [Evidence IMP] [PMID 10329624]
AWJ20_4694	Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate transporter; involved in mitochondrial iron homeostasis and in activating mitochondrial Sod2p by facilitating insertion of an essential manganese cofactor; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12890866]; GO_function: GO:0016530 - metallochaperone activity [Evidence IMP] [PMID 12890866]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IDA] [PMID 24184947]; GO_process: GO:0006828 - manganese ion transport [Evidence IMP] [PMID 12890866]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4695	Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors; GO_component: GO:0031931 - TORC1 complex [Evidence IEA]; GO_component: GO:0031931 - TORC1 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 16394584]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 17560372]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16394584]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0031929 - TOR signaling [Evidence IEA]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0009267 - cellular response to starvation [Evidence IMP] [PMID 12408816]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]
AWJ20_4696	Component of the GSE complex; GSE is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature; GO_component: GO:0034448 - EGO complex [Evidence IDA] [PMID 16732272]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16888326]; GO_component: GO:0031902 - late endosome membrane [Evidence IDA] [PMID 16732272]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16888326]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 16738661]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15611164]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 15611164]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 15611164]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IGI,IMP] [PMID 16888326]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4697	Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11274162]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015186 - L-glutamine transmembrane transporter activity [Evidence IGI,IMP] [PMID 11274162]; GO_function: GO:0015188 - L-isoleucine transmembrane transporter activity [Evidence IGI,IMP] [PMID 11274162]; GO_function: GO:0005302 - L-tyrosine transmembrane transporter activity [Evidence IGI,IMP] [PMID 11274162]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11274162]; GO_process: GO:0032974 - amino acid transmembrane export from vacuole [Evidence IGI,IMP] [PMID 11274162]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4698	RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 15612920]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 8065349]; GO_process: GO:0006384 - transcription initiation from RNA polymerase III promoter [Evidence IMP] [PMID 15612920]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4699	Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; SDH1 has a paralog, YJL045W, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IDA] [PMID 1939170]; GO_component: GO:0005749 - mitochondrial respiratory chain complex II [Evidence IDA] [PMID 9822678]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 2826438]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IDA] [PMID 18279395]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IMP] [PMID 1939170]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IEA]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IDA] [PMID 13445213]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IGI,IMP] [PMID 16232921]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IMP] [PMID 197391]; GO_function: GO:0008177 - succinate dehydrogenase (ubiquinone) activity [Evidence IMP] [PMID 9730279]; GO_process: GO:0045333 - cellular respiration [Evidence IGI,IMP] [PMID 16232921]; GO_process: GO:0045333 - cellular respiration [Evidence IGI,IMP] [PMID 9730279]; GO_process: GO:0022900 - electron transport chain [Evidence IEA]; GO_process: GO:0006121 - mitochondrial electron transport, succinate to ubiquinone [Evidence IDA] [PMID 2826438]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IC] [PMID 13445213]
AWJ20_4700	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IGI,IMP] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12768207]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12730134]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12768207]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]
AWJ20_4701	ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA] [PMID 9741626]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7754704]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 19843524]; GO_process: GO:0045732 - positive regulation of protein catabolic process [Evidence IDA] [PMID 15135049]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19412160]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IPI] [PMID 15135049]
AWJ20_4703	RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1850323]; GO_function: GO:0008419 - RNA lariat debranching enzyme activity [Evidence IDA,IMP] [PMID 1850323]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_process: GO:0006401 - RNA catabolic process [Evidence IDA,IMP] [PMID 1850323]; GO_process: GO:0006397 - mRNA processing [Evidence IEA,IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 24919400]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9055077]; GO_process: GO:0016074 - snoRNA metabolic process [Evidence IMP] [PMID 9740128]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence IMP] [PMID 10652222]
AWJ20_4704	Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 15590835]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_4705	Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 8001120]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 8001120]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H [Evidence IEA]; GO_function: GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H [Evidence IDA] [PMID 8001120]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11420140]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 10622712]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4706	NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0047453 - ATP-dependent NAD(P)H-hydrate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0047453 - ATP-dependent NAD(P)H-hydrate dehydratase activity [Evidence IDA] [PMID 21994945]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0046496 - nicotinamide nucleotide metabolic process [Evidence IEA]; GO_process: GO:0046496 - nicotinamide nucleotide metabolic process [Evidence IDA] [PMID 21994945]
AWJ20_4708	Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 9407032]; GO_component: GO:0000776 - kinetochore [Evidence IPI] [PMID 11070082]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IMP] [PMID 20935143]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IPI] [PMID 8665859]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 7891681]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9894911]; GO_function: GO:0001078 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [Evidence IDA] [PMID 15302821]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 7891681]; GO_function: GO:0001103 - RNA polymerase II repressing transcription factor binding [Evidence IDA] [PMID 12820973]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IMP] [PMID 12820973]; GO_function: GO:0001076 - RNA polymerase II transcription factor binding transcription factor activity [Evidence IMP] [PMID 20935143]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 11222754]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 2057354]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 2249662]; GO_function: GO:0019237 - centromeric DNA binding [Evidence IDA] [PMID 9407032]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 15111622]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 21131275]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 2249662]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 7891681]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 2057354]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 2185892]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 2188087]; GO_process: GO:0007059 - chromosome segregation [Evidence IGI] [PMID 9584087]; GO_process: GO:0061427 - negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter [Evidence IMP] [PMID 15302821]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10921921]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22696683]; GO_process: GO:1900375 - positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17351075]; GO_process: GO:1900375 - positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 20935143]; GO_process: GO:1900478 - positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7601277]; GO_process: GO:1900478 - positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7891681]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22696683]; GO_process: GO:0061432 - regulation of transcription from RNA polymerase II promoter in response to methionine [Evidence IMP] [PMID 7891681]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4710	Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000796 - condensin complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IPI,ISS] [PMID 10749931]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IDA] [PMID 10811823]; GO_component: GO:0000799 - nuclear condensin complex [Evidence IPI,ISS] [PMID 7698648]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10749931]; GO_function: GO:0003682 - chromatin binding [Evidence IGI] [PMID 11864994]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IMP] [PMID 24062159]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IEA]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IGI,IMP] [PMID 10749931]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 10811823]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 7698648]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 10749931]; GO_process: GO:0070058 - tRNA gene clustering [Evidence IMP] [PMID 18708579]
AWJ20_4712	Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IDA] [PMID 16675952]; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IMP] [PMID 17296727]; GO_component: GO:0031461 - cullin-RING ubiquitin ligase complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 12676951]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16675952]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17296727]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IC] [PMID 12676951]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence ISS] [PMID 9531531]
AWJ20_4714	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IBA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 3915776]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IBA]
AWJ20_4717	Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 15231838]; GO_component: GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome [Evidence IDA] [PMID 17515605]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4718	Putative paralog of ATR1; but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4721	Mitochondrial ribosomal component of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]
AWJ20_4722	CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus, in physically and genetically separate activity, binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 8552082]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IDA] [PMID 19201756]; GO_function: GO:0008179 - adenylate cyclase binding [Evidence IDA] [PMID 2184942]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IMP] [PMID 9774417]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IDA,IMP] [PMID 19201756]; GO_process: GO:0051014 - actin filament severing [Evidence IDA] [PMID 23135996]; GO_process: GO:0000902 - cell morphogenesis [Evidence IEA]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IEA]
AWJ20_4723	Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; GO_component: GO:0031011 - Ino80 complex [Evidence IEA]; GO_component: GO:0031011 - Ino80 complex [Evidence IDA,IMP] [PMID 12887900]; GO_component: GO:0031011 - Ino80 complex [Evidence IDA] [PMID 15525518]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10923024]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11011149]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 12887900]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 15525518]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 12887900]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4725	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9767141]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016428 - tRNA (cytosine-5-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0016428 - tRNA (cytosine-5-)-methyltransferase activity [Evidence IDA] [PMID 10445884]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 17567576]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0070301 - cellular response to hydrogen peroxide [Evidence IMP] [PMID 22760636]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 10445884]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0002127 - wobble base cytosine methylation [Evidence IMP] [PMID 22760636]
AWJ20_4726	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9851972]; GO_component: GO:0031515 - tRNA (m1A) methyltransferase complex [Evidence IDA,IPI] [PMID 10779558]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016429 - tRNA (adenine-N1-)-methyltransferase activity [Evidence IDA] [PMID 10779558]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 10779558]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_4727	S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA,IMP] [PMID 16321977]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008276 - protein methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006479 - protein methylation [Evidence IEA]; GO_process: GO:0006451 - translational readthrough [Evidence IGI] [PMID 16321977]
AWJ20_4728	Putative cysteine synthase; localized to the mitochondrial outer membrane; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004124 - cysteine synthase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006535 - cysteine biosynthetic process from serine [Evidence IEA]
AWJ20_4729	Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IDA] [PMID 17550305]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IMP] [PMID 2176150]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IGI] [PMID 12518319]; GO_process: GO:0007015 - actin filament organization [Evidence TAS] [PMID 9001215]; GO_process: GO:0007117 - budding cell bud growth [Evidence TAS] [PMID 9001215]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IPI] [PMID 9001215]; GO_process: GO:0006470 - protein dephosphorylation [Evidence TAS] [PMID 9001215]; GO_process: GO:0006417 - regulation of translation [Evidence IPI] [PMID 10329624]
AWJ20_4730	Subunit (61/68 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA,IPI] [PMID 12501245]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA] [PMID 10751405]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10817999]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9674426]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006352 - DNA-templated transcription, initiation [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12600943]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0016568 - chromatin modification [Evidence IDA,IMP] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 10751405]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11561287]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 12582246]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4732	One of four subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; ESCRT-III stands for endosomal sorting complex required for transport III; GO_component: GO:0000815 - ESCRT III complex [Evidence IDA] [PMID 12194857]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9606181]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 15086794]; GO_process: GO:0071454 - cellular response to anoxia [Evidence IMP] [PMID 20402793]; GO_process: GO:0070676 - intralumenal vesicle formation [Evidence IMP] [PMID 19234443]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 9606181]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IC] [PMID 15086794]
AWJ20_4733	cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 11001058]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 11959998]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 9725919]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 1400588]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 11001058]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 11959998]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 9545229]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 7596416]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11001046]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IMP] [PMID 9545229]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_4736	Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]
AWJ20_4737	Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4738	Chromatin associated high mobility group (HMG) family member; involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8969238]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16612005]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 17646381]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12374750]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 22553361]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 15507436]; GO_function: GO:0008301 - DNA binding, bending [Evidence IDA] [PMID 16533046]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 15507436]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 16533046]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 15507436]; GO_function: GO:0000400 - four-way junction DNA binding [Evidence IDA] [PMID 16533046]; GO_process: GO:0060962 - regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17875934]; GO_process: GO:0060962 - regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 18187511]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IDA] [PMID 18451108]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IGI] [PMID 12374750]; GO_process: GO:0006356 - regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 16612005]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4739	Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10672016]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008374 - O-acyltransferase activity [Evidence IEA]; GO_function: GO:0034736 - cholesterol O-acyltransferase activity [Evidence IEA]; GO_function: GO:0034737 - ergosterol O-acyltransferase activity [Evidence IGI,IMP] [PMID 10672016]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0008204 - ergosterol metabolic process [Evidence IGI,IMP] [PMID 10672016]
AWJ20_4743	Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IPI] [PMID 15044395]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 2182636]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0019187 - beta-1,4-mannosyltransferase activity [Evidence IDA] [PMID 6368538]; GO_function: GO:0004578 - chitobiosyldiphosphodolichol beta-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA,IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006490 - oligosaccharide-lipid intermediate biosynthetic process [Evidence IMP] [PMID 7037780]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 6369318]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_4745	Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 1639847]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 1639847]; GO_component: GO:0005823 - central plaque of spindle pole body [Evidence IDA] [PMID 8601600]; GO_component: GO:0005823 - central plaque of spindle pole body [Evidence IDA] [PMID 8886974]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 1639847]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 1639847]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 3533275]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 8461293]; GO_function: GO:0048306 - calcium-dependent protein binding [Evidence IDA] [PMID 1321337]; GO_function: GO:0048306 - calcium-dependent protein binding [Evidence IPI] [PMID 9756868]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10749918]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 7925277]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 8247006]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 8294515]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 9450989]; GO_process: GO:0006607 - NLS-bearing protein import into nucleus [Evidence IMP] [PMID 17878171]; GO_process: GO:0007114 - cell budding [Evidence IMP] [PMID 8310294]; GO_process: GO:0007010 - cytoskeleton organization [Evidence IMP] [PMID 8310294]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IGI,IMP] [PMID 12836012]; GO_process: GO:0016237 - microautophagy [Evidence IMP] [PMID 16055436]; GO_process: GO:0006661 - phosphatidylinositol biosynthetic process [Evidence IGI,IMP] [PMID 12079494]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IMP] [PMID 7988551]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IMP] [PMID 9450989]; GO_process: GO:0051300 - spindle pole body organization [Evidence IMP] [PMID 1469052]; GO_process: GO:0042991 - transcription factor import into nucleus [Evidence IMP] [PMID 17878171]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IDA,IMP] [PMID 9859992]
AWJ20_4748	Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA] [PMID 10582239]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 14747994]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IPI] [PMID 17141224]; GO_function: GO:0030674 - protein binding, bridging [Evidence ISA] [PMID 10582239]; GO_function: GO:0030674 - protein binding, bridging [Evidence ISA] [PMID 9635407]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISA] [PMID 10582239]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence ISA] [PMID 9635407]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IGI,ISA] [PMID 10582239]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence ISA] [PMID 9635407]; GO_process: GO:0071406 - cellular response to methylmercury [Evidence IMP] [PMID 17141224]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
AWJ20_4749	Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 23673619]; GO_component: GO:0051286 - cell tip [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9214378]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 2647769]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9214378]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 2647769]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9214378]; GO_component: GO:0000133 - polarisome [Evidence IDA] [PMID 9632790]; GO_function: GO:0005078 - MAP-kinase scaffold activity [Evidence IDA,IMP] [PMID 12361575]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 8909546]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 10866679]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8013906]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8909546]; GO_process: GO:0036267 - invasive filamentous growth [Evidence IGI] [PMID 9443897]; GO_process: GO:0031382 - mating projection assembly [Evidence IGI] [PMID 9443897]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IGI,IMP] [PMID 12857882]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IMP] [PMID 19633059]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9055077]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9443897]; GO_process: GO:0008360 - regulation of cell shape [Evidence IEA]; GO_process: GO:0031384 - regulation of initiation of mating projection growth [Evidence IMP] [PMID 14734532]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 10085294]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 11740491]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 12857882]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 16166638]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 8909546]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 9571251]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 9632790]; GO_process: GO:0031385 - regulation of termination of mating projection growth [Evidence IMP] [PMID 14734532]
AWJ20_4750	Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 23673619]; GO_component: GO:0051286 - cell tip [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9214378]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 2647769]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9214378]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 2647769]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9214378]; GO_component: GO:0000133 - polarisome [Evidence IDA] [PMID 9632790]; GO_function: GO:0005078 - MAP-kinase scaffold activity [Evidence IDA,IMP] [PMID 12361575]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 8909546]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 10866679]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8013906]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 8909546]; GO_process: GO:0036267 - invasive filamentous growth [Evidence IGI] [PMID 9443897]; GO_process: GO:0031382 - mating projection assembly [Evidence IGI] [PMID 9443897]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IGI,IMP] [PMID 12857882]; GO_process: GO:2000251 - positive regulation of actin cytoskeleton reorganization [Evidence IMP] [PMID 19633059]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9055077]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9443897]; GO_process: GO:0008360 - regulation of cell shape [Evidence IEA]; GO_process: GO:0031384 - regulation of initiation of mating projection growth [Evidence IMP] [PMID 14734532]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 10085294]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 11740491]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 12857882]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 16166638]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 8909546]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 9571251]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 9632790]; GO_process: GO:0031385 - regulation of termination of mating projection growth [Evidence IMP] [PMID 14734532]
AWJ20_4751	Putative amidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004040 - amidase activity [Evidence IEA]; GO_function: GO:0004040 - amidase activity [Evidence ISS] [PMID 2263500]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
AWJ20_4752	Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0046316 - gluconokinase activity [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046177 - D-gluconate catabolic process [Evidence IEA]; GO_process: GO:0019521 - D-gluconate metabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4753	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]
AWJ20_4754	RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9154839]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 18975973]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9154839]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9154839]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9154839]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0048254 - snoRNA localization [Evidence IMP] [PMID 18833290]
AWJ20_4755	Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0000276 - mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IEA]; GO_component: GO:0000276 - mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IMP,IPI,ISS] [PMID 10336613]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0045263 - proton-transporting ATP synthase complex, coupling factor F(o) [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0005198 - structural molecule activity [Evidence IMP,IPI] [PMID 9857174]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,ISS] [PMID 10336613]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,IPI] [PMID 9857174]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 19528297]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 17761666]; GO_process: GO:0035786 - protein complex oligomerization [Evidence IMP] [PMID 16551625]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4757	Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10077572]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IEA]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence IDA] [PMID 10600176]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 10077572]
AWJ20_4758	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IEA]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IDA] [PMID 12003496]; GO_function: GO:0017150 - tRNA dihydrouridine synthase activity [Evidence IMP] [PMID 14970222]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0002943 - tRNA dihydrouridine synthesis [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 12003496]; GO_process: GO:0006400 - tRNA modification [Evidence IMP] [PMID 14970222]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
AWJ20_4760	Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14573466]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006972 - hyperosmotic response [Evidence IMP,IPI] [PMID 14685261]; GO_process: GO:0000200 - inactivation of MAPK activity involved in cell wall organization or biogenesis [Evidence IMP,IPI] [PMID 22570491]; GO_process: GO:0006469 - negative regulation of protein kinase activity [Evidence IDA] [PMID 14685261]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 14573466]
AWJ20_4762	Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; GO_component: GO:0033186 - CAF-1 complex [Evidence IDA] [PMID 9030687]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 11782447]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9030688]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 16503640]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IDA] [PMID 9030687]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IMP] [PMID 9030688]
AWJ20_4763	hypothetical protein involved in vacuolar protein sorting; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4765	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally propionylated in vivo; protein abundance increases in response to DNA replication stress; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000118 - histone deacetylase complex [Evidence IPI] [PMID 15643056]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15643056]; GO_function: GO:0016018 - cyclosporin A binding [Evidence IMP] [PMID 7515500]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0042277 - peptide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 2687115]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 15643056]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IMP] [PMID 11641409]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IMP] [PMID 12242280]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045836 - positive regulation of meiosis [Evidence IGI,IMP] [PMID 15643056]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4766	Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0030125 - clathrin vesicle coat [Evidence IDA] [PMID 12483220]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12967568]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IDA] [PMID 12967568]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 14630930]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 14630930]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 12483220]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 12483220]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence ISS] [PMID 10449404]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 12967568]; GO_process: GO:0007015 - actin filament organization [Evidence ISS] [PMID 10449404]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IGI] [PMID 20658963]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IMP] [PMID 15107463]; GO_process: GO:0071985 - multivesicular body sorting pathway [Evidence IMP] [PMID 12967568]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4767	Highly-acidic RWD domain-containing hypothetical protein; cytoplasmic; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 19448108]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI] [PMID 21076151]
AWJ20_4769	Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0097373 - MCM core complex [Evidence IDA] [PMID 13679365]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10559985]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10559985]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IDA] [PMID 15723534]; GO_function: GO:1990163 - ATP-dependent four-way junction helicase activity [Evidence IDA] [PMID 13679365]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IMP] [PMID 17895243]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0043142 - single-stranded DNA-dependent ATPase activity [Evidence IDA] [PMID 15723534]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI] [PMID 2044962]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 13679365]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 15723534]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 2044962]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]
AWJ20_4770	Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 8917313]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 8917313]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 12637560]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8917313]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 12637560]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4772	Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10757808]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10757808]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA,IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IGI,IMP] [PMID 18694928]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IDA] [PMID 23919454]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006037 - cell wall chitin metabolic process [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0071555 - cell wall organization [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 18694928]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4776	Cytoplasmic RNA-binding protein; contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10764794]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA] [PMID 10764794]; GO_process: GO:0016071 - mRNA metabolic process [Evidence IGI] [PMID 10764794]
AWJ20_4778	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISM] [PMID 19351663]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4779	Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4780	Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; KEL1 has a paralog, KEL2, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 23673619]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 9786949]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 9786949]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 9786949]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000755 - cytogamy [Evidence IGI,IMP,IPI] [PMID 9786949]; GO_process: GO:0001100 - negative regulation of exit from mitosis [Evidence IMP,IPI] [PMID 12234925]; GO_process: GO:0008360 - regulation of cell shape [Evidence IMP] [PMID 9786949]
AWJ20_4783	Putative ATP-dependent permease of the ABC transporter family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence ISS] [PMID 9020838]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9020838]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4787	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 11553703]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IDA] [PMID 16687570]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 18948116]; GO_process: GO:0072318 - clathrin coat disassembly [Evidence IMP] [PMID 11146663]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IMP] [PMID 11553703]; GO_process: GO:0032781 - positive regulation of ATPase activity [Evidence IDA] [PMID 16687570]
AWJ20_4788	Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000439 - core TFIIH complex [Evidence IEA]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IDA] [PMID 8855246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 15909982]; GO_function: GO:0010314 - phosphatidylinositol-5-phosphate binding [Evidence IDA] [PMID 15909982]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 7891722]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IMP] [PMID 12015980]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_4789	Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10792726]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 16413483]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IGI,IPI] [PMID 11054575]; GO_function: GO:0051082 - unfolded protein binding [Evidence ISS] [PMID 9488429]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI,IPI] [PMID 11054575]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI,IMP] [PMID 11929994]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 20368619]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IMP] [PMID 15456889]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 16607023]
AWJ20_4790	Subunit of a heterodimeric peroxisomal ABC transport complex; required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; complex also includes Pxa2p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005779 - integral component of peroxisomal membrane [Evidence IDA] [PMID 8670886]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IMP,ISS] [PMID 8670886]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0015908 - fatty acid transport [Evidence IMP] [PMID 8670886]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_4792	Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 23204190]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 23204190]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015079 - potassium ion transmembrane transporter activity [Evidence IDA] [PMID 23204190]; GO_process: GO:0071805 - potassium ion transmembrane transport [Evidence IDA] [PMID 23204190]
AWJ20_4793	Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals; GO_component: GO:0097586 - dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex [Evidence IPI] [PMID 12551906]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IEA]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IDA,IMP] [PMID 21956107]; GO_function: GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity [Evidence IMP,ISS] [PMID 8585318]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IEA]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IMP,ISS] [PMID 8585318]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IMP] [PMID 18182384]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IMP] [PMID 21231968]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IGI] [PMID 21231968]
AWJ20_4794	Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 10681587]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4795	Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17287526]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 15590673]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031982 - vesicle [Evidence IDA] [PMID 17287526]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 17287526]
AWJ20_4796	GTP-cyclohydrolase I; catalyzes the first step in the folic acid biosynthetic pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003934 - GTP cyclohydrolase I activity [Evidence IEA,IEA]; GO_function: GO:0003934 - GTP cyclohydrolase I activity [Evidence IMP] [PMID 8573145]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0035998 - 7,8-dihydroneopterin 3'-triphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0046656 - folic acid biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IMP] [PMID 8573145]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046654 - tetrahydrofolate biosynthetic process [Evidence IEA]
AWJ20_4797	Cytoplasmic protein containing a zinc finger domain; sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11489916]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4802	Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 23740823]; GO_function: GO:0003867 - 4-aminobutyrate transaminase activity [Evidence IEA,IEA]; GO_function: GO:0003867 - 4-aminobutyrate transaminase activity [Evidence IMP] [PMID 3888627]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 3888627]; GO_process: GO:0009448 - gamma-aminobutyric acid metabolic process [Evidence IEA]
AWJ20_4805	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11726524]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15710377]; GO_component: GO:0017102 - methionyl glutamyl tRNA synthetase complex [Evidence IMP,IPI] [PMID 9659920]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 11069915]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0000049 - tRNA binding [Evidence IEA,IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IMP,IPI] [PMID 11726524]; GO_process: GO:0051351 - positive regulation of ligase activity [Evidence IDA] [PMID 11069915]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IMP] [PMID 9659920]
AWJ20_4807	Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p; GO_component: GO:0000439 - core TFIIH complex [Evidence IEA]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IPI] [PMID 10681587]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 10506223]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4808	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 2060626]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 2060626]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 2060626]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_4809	Integral plasma membrane protein; involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 10329735]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10329735]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 15452134]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IMP] [PMID 10329735]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 10329735]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 15452134]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4810	Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 11585915]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4811	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 1544898]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 1544898]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 1544898]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4814	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain; GO_component: GO:0005794 - Golgi apparatus [Evidence ISS] [PMID 7975899]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 7975899]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence ISS] [PMID 7975899]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]
AWJ20_4815	Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10366597]; GO_component: GO:0005884 - actin filament [Evidence IDA] [PMID 23333351]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IPI] [PMID 7719850]; GO_process: GO:0030042 - actin filament depolymerization [Evidence IGI,IPI] [PMID 10366597]; GO_process: GO:0051016 - barbed-end actin filament capping [Evidence IMP] [PMID 23333351]; GO_process: GO:0006970 - response to osmotic stress [Evidence TAS] [PMID 10652251]
AWJ20_4816	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0015124 - allantoate transmembrane transporter activity [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IMP] [PMID 16429164]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IGI,IMP] [PMID 17693598]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015719 - allantoate transport [Evidence IMP] [PMID 3275614]; GO_process: GO:0042938 - dipeptide transport [Evidence IMP] [PMID 16429164]; GO_process: GO:0042938 - dipeptide transport [Evidence IGI,IMP] [PMID 17693598]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IMP] [PMID 16429164]
AWJ20_4817	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0015124 - allantoate transmembrane transporter activity [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IMP] [PMID 16429164]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IGI,IMP] [PMID 17693598]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015719 - allantoate transport [Evidence IMP] [PMID 3275614]; GO_process: GO:0042938 - dipeptide transport [Evidence IMP] [PMID 16429164]; GO_process: GO:0042938 - dipeptide transport [Evidence IGI,IMP] [PMID 17693598]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IMP] [PMID 16429164]
AWJ20_4818	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0015124 - allantoate transmembrane transporter activity [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IMP] [PMID 16429164]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IGI,IMP] [PMID 17693598]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015719 - allantoate transport [Evidence IMP] [PMID 3275614]; GO_process: GO:0042938 - dipeptide transport [Evidence IMP] [PMID 16429164]; GO_process: GO:0042938 - dipeptide transport [Evidence IGI,IMP] [PMID 17693598]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IMP] [PMID 16429164]
AWJ20_4819	Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0033553 - rDNA heterochromatin [Evidence IDA] [PMID 15489292]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0034455 - t-UTP complex [Evidence IDA] [PMID 17515605]; GO_function: GO:0030515 - snoRNA binding [Evidence IPI] [PMID 12068309]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4821	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA; also required for the Oli1p ring formation; YMR098C is not an essential gene; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 18216280]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0048255 - mRNA stabilization [Evidence IEA]; GO_process: GO:0048255 - mRNA stabilization [Evidence IMP] [PMID 18216280]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP] [PMID 18216280]
AWJ20_4823	Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12139626]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12139626]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 15772087]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016049 - cell growth [Evidence IPI] [PMID 12139626]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 15772087]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4824	Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12808030]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISA] [PMID 12808030]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI,IMP] [PMID 12808030]
AWJ20_4826	Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0010308 - acireductone dioxygenase (Ni2+-requiring) activity [Evidence IMP] [PMID 15938715]; GO_function: GO:0010309 - acireductone dioxygenase [iron(II)-requiring] activity [Evidence IEA,IEA,IEA]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA,IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IGI,IMP,ISS] [PMID 15938715]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4827	Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; GO_component: GO:0000938 - GARP complex [Evidence IPI] [PMID 10637310]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 10637310]; GO_component: GO:0005794 - Golgi apparatus [Evidence TAS] [PMID 11689439]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 10637310]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IDA] [PMID 12686613]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4828	Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p; GO_component: GO:0070274 - RES complex [Evidence IDA] [PMID 15565172]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 15565172]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 15565172]; GO_process: GO:0051237 - maintenance of RNA location [Evidence IMP] [PMID 16162818]
AWJ20_4829	DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IC] [PMID 16209945]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IMP] [PMID 16209945]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 18975973]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 16209945]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4830	DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11278831]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 15222769]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 15222769]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046403 - polynucleotide 3'-phosphatase activity [Evidence IEA]; GO_function: GO:0046403 - polynucleotide 3'-phosphatase activity [Evidence IDA] [PMID 11278831]; GO_function: GO:0046403 - polynucleotide 3'-phosphatase activity [Evidence IMP] [PMID 15222769]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI,IMP] [PMID 11585902]; GO_process: GO:0098506 - polynucleotide 3' dephosphorylation [Evidence IEA]
AWJ20_4831	Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IDA] [PMID 18782943]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4835	Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0043529 - GET complex [Evidence IEA]; GO_component: GO:0043529 - GET complex [Evidence IPI] [PMID 16269340]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 12680698]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 18261907]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 18261907]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IDA] [PMID 20850366]; GO_process: GO:0045048 - protein insertion into ER membrane [Evidence IEA]; GO_process: GO:0045048 - protein insertion into ER membrane [Evidence IMP] [PMID 18724936]; GO_process: GO:0046685 - response to arsenic-containing substance [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 12680698]; GO_process: GO:0010038 - response to metal ion [Evidence IMP] [PMID 12680698]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IDA,IGI,IMP] [PMID 16269340]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_4837	Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; GO_component: GO:0005768 - endosome [Evidence IPI] [PMID 9700157]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22593205]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0030904 - retromer complex [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030906 - retromer complex, inner shell [Evidence IPI] [PMID 9700157]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4838	Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; GO_component: GO:0005768 - endosome [Evidence IPI] [PMID 9700157]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22593205]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0030904 - retromer complex [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030906 - retromer complex, inner shell [Evidence IPI] [PMID 9700157]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4840	hypothetical protein that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 10093218]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_4841	Transmembrane protein; subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IEA]; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IDA] [PMID 15939668]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15075373]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15939668]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IMP,ISS] [PMID 11483512]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP,ISS] [PMID 11483512]
AWJ20_4842	Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4844	Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8385141]; GO_component: GO:0005829 - cytosol [Evidence IBA]; GO_function: GO:0016868 - intramolecular transferase activity, phosphotransferases [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IEA]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IMP] [PMID 13887540]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IMP] [PMID 2138705]; GO_function: GO:0004614 - phosphoglucomutase activity [Evidence IGI,IMP,ISS] [PMID 8119301]; GO_process: GO:0006011 - UDP-glucose metabolic process [Evidence IGI] [PMID 9252577]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 10681519]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI,IMP] [PMID 15252028]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IMP] [PMID 15164360]; GO_process: GO:0019388 - galactose catabolic process [Evidence IMP] [PMID 13887540]; GO_process: GO:0019388 - galactose catabolic process [Evidence IMP] [PMID 14264884]; GO_process: GO:0019388 - galactose catabolic process [Evidence IGI,IMP] [PMID 8119301]; GO_process: GO:0019255 - glucose 1-phosphate metabolic process [Evidence IMP] [PMID 10681519]; GO_process: GO:0019255 - glucose 1-phosphate metabolic process [Evidence IGI,IMP,ISS] [PMID 8119301]; GO_process: GO:0051156 - glucose 6-phosphate metabolic process [Evidence ISS] [PMID 8119301]; GO_process: GO:0006006 - glucose metabolic process [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IGI] [PMID 9252577]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IGI] [PMID 9252577]
AWJ20_4845	Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; GO_component: GO:0043564 - Ku70:Ku80 complex [Evidence IEA]; GO_component: GO:0043564 - Ku70:Ku80 complex [Evidence IDA] [PMID 8754818]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence TAS] [PMID 10367891]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence TAS] [PMID 12080091]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 16166630]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12975323]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence TAS] [PMID 10367891]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IDA] [PMID 17656141]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IDA] [PMID 11553718]; GO_process: GO:0006342 - chromatin silencing [Evidence IDA,IMP] [PMID 9501103]; GO_process: GO:0007535 - donor selection [Evidence IDA,IMP] [PMID 16166630]; GO_process: GO:0007535 - donor selection [Evidence IGI,IMP] [PMID 16809780]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 11016833]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IEA]; GO_process: GO:0034502 - protein localization to chromosome [Evidence IGI] [PMID 18716325]; GO_process: GO:0000723 - telomere maintenance [Evidence IEA]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 10818099]
AWJ20_4846	Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10993714]; GO_function: GO:0008108 - UDP-glucose:hexose-1-phosphate uridylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008108 - UDP-glucose:hexose-1-phosphate uridylyltransferase activity [Evidence IMP] [PMID 14158615]; GO_function: GO:0008108 - UDP-glucose:hexose-1-phosphate uridylyltransferase activity [Evidence IDA] [PMID 387754]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IMP] [PMID 14158615]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IDA] [PMID 387754]; GO_process: GO:0006012 - galactose metabolic process [Evidence IEA,IEA,IEA]
AWJ20_4847	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IGI,IMP] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12730134]; GO_component: GO:0000811 - GINS complex [Evidence IPI] [PMID 12768207]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12730134]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IMP] [PMID 12768207]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]
AWJ20_4850	Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex; GO_component: GO:0036396 - MIS complex [Evidence IDA,IPI] [PMID 22685417]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 22685417]; GO_process: GO:0080009 - mRNA methylation [Evidence IGI,IMP] [PMID 22685417]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 22685417]; GO_process: GO:2000221 - negative regulation of pseudohyphal growth [Evidence IMP] [PMID 22685417]; GO_process: GO:0006279 - premeiotic DNA replication [Evidence IGI] [PMID 11238403]; GO_process: GO:0006279 - premeiotic DNA replication [Evidence IMP] [PMID 9504908]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_4852	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity [Evidence IEA,IEA]; GO_function: GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity [Evidence IDA] [PMID 2880280]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence IEA]; GO_process: GO:0009423 - chorismate biosynthetic process [Evidence TAS] [PMID 1943992]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_4854	Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 15588312]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IMP,ISS] [PMID 15588312]
AWJ20_4855	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4856	N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 1544917]; GO_function: GO:0004379 - glycylpeptide N-tetradecanoyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004379 - glycylpeptide N-tetradecanoyltransferase activity [Evidence IMP] [PMID 8955162]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0018008 - N-terminal peptidyl-glycine N-myristoylation [Evidence TAS] [PMID 10570244]; GO_process: GO:0006499 - N-terminal protein myristoylation [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 10921902]
AWJ20_4857	Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005751 - mitochondrial respiratory chain complex IV [Evidence IPI] [PMID 1331058]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IMP] [PMID 1847916]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen [Evidence IDA] [PMID 1331058]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_4858	High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 8893857]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000102 - L-methionine secondary active transmembrane transporter activity [Evidence IDA] [PMID 8893857]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0042883 - cysteine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0044690 - methionine import [Evidence IGI,IMP] [PMID 8893857]; GO_process: GO:0015821 - methionine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0000101 - sulfur amino acid transport [Evidence IMP] [PMID 8893857]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4860	Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005829 - cytosol [Evidence TAS] [PMID 12052896]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12052896]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 12052896]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16301316]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IGI,IPI,ISS] [PMID 12052896]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 16301316]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 12052896]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IMP,ISS] [PMID 11169758]
AWJ20_4861	Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15470103]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8909536]; GO_component: GO:0045009 - chitosome [Evidence IDA] [PMID 8970154]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9008706]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9008706]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 15755916]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IMP] [PMID 9760183]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 1293886]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence TAS] [PMID 7565410]
AWJ20_4863	Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP,ISS] [PMID 2668951]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004815 - aspartate-tRNA ligase activity [Evidence IEA]; GO_function: GO:0004815 - aspartate-tRNA ligase activity [Evidence IMP,ISA] [PMID 2668951]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0070146 - mitochondrial aspartyl-tRNA aminoacylation [Evidence IGI] [PMID 10710420]; GO_process: GO:0070146 - mitochondrial aspartyl-tRNA aminoacylation [Evidence IMP] [PMID 2668951]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4864	Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19773362]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19773362]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15210724]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 11742986]; GO_component: GO:0008541 - proteasome regulatory particle, lid subcomplex [Evidence IDA] [PMID 9741626]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence ISS] [PMID 12183636]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IMP] [PMID 12183636]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IMP] [PMID 12353037]; GO_process: GO:0000266 - mitochondrial fission [Evidence IMP] [PMID 19773362]; GO_process: GO:0016559 - peroxisome fission [Evidence IMP] [PMID 19773362]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12183636]; GO_process: GO:0016579 - protein deubiquitination [Evidence IMP] [PMID 12183636]; GO_process: GO:0016579 - protein deubiquitination [Evidence IGI] [PMID 14581483]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_4865	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0000774 - adenyl-nucleotide exchange factor activity [Evidence IDA] [PMID 16688212]; GO_function: GO:0005516 - calmodulin binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence ISS] [PMID 8406043]; GO_process: GO:0042026 - protein refolding [Evidence IGI] [PMID 16688211]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_4866	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP); GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11598205]; GO_component: GO:0034098 - Cdc48p-Npl4p-Ufd1p AAA ATPase complex [Evidence IDA] [PMID 11733065]; GO_component: GO:0036266 - Cdc48p-Npl4p-Vms1p AAA ATPase complex [Evidence IDA] [PMID 21070972]; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873065]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:1990112 - RQC complex [Evidence IDA] [PMID 23178123]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 11598205]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11740563]; GO_process: GO:0071712 - ER-associated misfolded protein catabolic process [Evidence IMP] [PMID 11813000]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11739805]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18812321]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0072671 - mitochondria-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21070972]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 14636562]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 22505030]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11598205]; GO_process: GO:1900182 - positive regulation of protein localization to nucleus [Evidence IMP] [PMID 11733065]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20206597]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030970 - retrograde protein transport, ER to cytosol [Evidence IMP] [PMID 11740563]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4869	GYF domain protein; involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 17804396]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 17973654]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 17973654]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 17973654]
AWJ20_4870	Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10022888]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 10022888]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IDA] [PMID 24681967]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_4871	Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11922673]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11922673]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IDA] [PMID 10975253]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI] [PMID 17431397]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 9491890]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9491890]
AWJ20_4872	Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16643908]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004741 - [pyruvate dehydrogenase (lipoamide)] phosphatase activity [Evidence IEA]; GO_function: GO:0004741 - [pyruvate dehydrogenase (lipoamide)] phosphatase activity [Evidence ISS] [PMID 16643908]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA,ISS] [PMID 10580002]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IMP] [PMID 18180296]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IEA]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 10580002]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IMP] [PMID 16643908]
AWJ20_4873	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0047938 - glucose-6-phosphate 1-epimerase activity [Evidence IEA]; GO_function: GO:0047938 - glucose-6-phosphate 1-epimerase activity [Evidence IDA] [PMID 16857670]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IC] [PMID 16857670]
AWJ20_4874	Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p; GO_component: GO:0016023 - cytoplasmic membrane-bounded vesicle [Evidence IDA] [PMID 10748025]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 19469713]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0015344 - siderophore uptake transmembrane transporter activity [Evidence IMP,ISS] [PMID 9884238]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IDA,IMP] [PMID 9884238]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0015891 - siderophore transport [Evidence IMP] [PMID 9884238]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 9884238]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4877	Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IMP] [PMID 11872141]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 8163546]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 22748138]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IGI,IMP] [PMID 23612966]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8163546]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 22748138]; GO_process: GO:0036258 - multivesicular body assembly [Evidence IGI] [PMID 22748138]; GO_process: GO:0036010 - protein localization to endosome [Evidence IGI] [PMID 23264632]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8163546]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0000011 - vacuole inheritance [Evidence IMP] [PMID 1493335]
AWJ20_4879	Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IEA,IEA]; GO_function: GO:0004451 - isocitrate lyase activity [Evidence IMP,ISS] [PMID 1551398]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0019752 - carboxylic acid metabolic process [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA,IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence TAS] [PMID 11092862]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
AWJ20_4880	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10931290]; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 10931290]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA,IGI] [PMID 10526184]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA,IMP] [PMID 18845541]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA,IMP] [PMID 18845541]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 21215255]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA,IMP] [PMID 18845541]; GO_function: GO:0010314 - phosphatidylinositol-5-phosphate binding [Evidence IDA,IMP] [PMID 18845541]; GO_process: GO:0007231 - osmosensory signaling pathway [Evidence IGI] [PMID 10590461]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16087742]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_4881	Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IDA] [PMID 16675952]; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IMP] [PMID 17296727]; GO_component: GO:0031461 - cullin-RING ubiquitin ligase complex [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0031625 - ubiquitin protein ligase binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 12676951]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16675952]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 17296727]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IC] [PMID 12676951]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence ISS] [PMID 9531531]
AWJ20_4882	Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990070 - TRAPPI protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:1990072 - TRAPPIII protein complex [Evidence IDA] [PMID 20375281]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 19843283]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 19843283]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 9564032]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IGI] [PMID 19843283]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_4884	GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 20162532]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 3513173]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 14674766]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 6327067]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0007189 - adenylate cyclase-activating G-protein coupled receptor signaling pathway [Evidence IDA] [PMID 3891097]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 2981630]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 3891097]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 12782684]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 8034612]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
AWJ20_4885	Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 16314178]; GO_component: GO:0033698 - Rpd3L complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0000118 - histone deacetylase complex [Evidence IDA] [PMID 12672825]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 16728974]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 17142463]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA,IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IMP,IPI,ISS] [PMID 10805724]; GO_process: GO:0061188 - negative regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 16286008]; GO_process: GO:0061186 - negative regulation of chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16286008]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16314178]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP] [PMID 19372273]; GO_process: GO:0016479 - negative regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 19270272]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 17210643]; GO_process: GO:0061408 - positive regulation of transcription from RNA polymerase II promoter in response to heat stress [Evidence IMP] [PMID 20398213]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4886	Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 14742425]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 14742425]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016071 - mRNA metabolic process [Evidence IMP] [PMID 14742425]; GO_process: GO:0070124 - mitochondrial translational initiation [Evidence IGI] [PMID 19843529]
AWJ20_4887	Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 16138904]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0008158 - hedgehog receptor activity [Evidence IEA]; GO_function: GO:0046624 - sphingolipid transporter activity [Evidence IMP] [PMID 14970192]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IMP] [PMID 14970192]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4889	Nuclear SAM-dependent mono- and asymmetric methyltransferase; modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8668183]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0035242 - protein-arginine omega-N asymmetric methyltransferase activity [Evidence IDA,IMP] [PMID 8647869]; GO_function: GO:0035241 - protein-arginine omega-N monomethyltransferase activity [Evidence IDA,IMP] [PMID 8647869]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI] [PMID 10952997]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI] [PMID 8668183]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0060567 - negative regulation of DNA-templated transcription, termination [Evidence IMP] [PMID 20053728]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IMP] [PMID 18515076]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IMP] [PMID 20035717]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IDA] [PMID 22997150]; GO_process: GO:0018216 - peptidyl-arginine methylation [Evidence IDA,IMP] [PMID 8647869]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 20053728]; GO_process: GO:0006479 - protein methylation [Evidence IEA]
AWJ20_4890	Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031166 - integral component of vacuolar membrane [Evidence IDA] [PMID 23022132]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015379 - potassium:chloride symporter activity [Evidence IMP,ISA] [PMID 23022132]; GO_process: GO:0055075 - potassium ion homeostasis [Evidence IGI] [PMID 23022132]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0034486 - vacuolar transmembrane transport [Evidence IMP] [PMID 23022132]
AWJ20_4891	Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031166 - integral component of vacuolar membrane [Evidence IDA] [PMID 23022132]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015379 - potassium:chloride symporter activity [Evidence IMP,ISA] [PMID 23022132]; GO_process: GO:0055075 - potassium ion homeostasis [Evidence IGI] [PMID 23022132]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0034486 - vacuolar transmembrane transport [Evidence IMP] [PMID 23022132]
AWJ20_4892	Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia; GO_component: GO:0016591 - DNA-directed RNA polymerase II, holoenzyme [Evidence IPI] [PMID 11018011]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11018011]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004482 - mRNA (guanine-N7-)-methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004482 - mRNA (guanine-N7-)-methyltransferase activity [Evidence IDA,ISS] [PMID 7623811]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IEA,IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IDA] [PMID 7623811]; GO_process: GO:0036265 - RNA (guanine-N7)-methylation [Evidence IEA,IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 14967145]
AWJ20_4896	Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4897	ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15049817]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 15718299]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 15718299]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 15718299]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 23788678]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15049817]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 15242642]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 15049817]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 23788678]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 15049817]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 23788678]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_4898	ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; GO_component: GO:0000262 - mitochondrial chromosome [Evidence IDA] [PMID 21911497]; GO_component: GO:0045025 - mitochondrial degradosome [Evidence IDA] [PMID 12426313]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 12426313]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 17658549]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008859 - exoribonuclease II activity [Evidence IDA] [PMID 17658549]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000372 - Group I intron splicing [Evidence IGI] [PMID 20064926]; GO_process: GO:0006264 - mitochondrial DNA replication [Evidence IMP] [PMID 21911497]; GO_process: GO:0000957 - mitochondrial RNA catabolic process [Evidence IMP] [PMID 12426313]
AWJ20_4899	Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IEA]; GO_component: GO:0005885 - Arp2/3 protein complex [Evidence IDA] [PMID 10377407]; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11248049]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA,IMP] [PMID 15657399]; GO_function: GO:0016887 - ATPase activity [Evidence IMP] [PMID 16862144]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IMP] [PMID 16862144]; GO_process: GO:0034314 - Arp2/3 complex-mediated actin nucleation [Evidence IEA]; GO_process: GO:0034314 - Arp2/3 complex-mediated actin nucleation [Evidence IMP] [PMID 16862144]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 18287533]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10377407]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 17118118]; GO_process: GO:0051654 - establishment of mitochondrion localization [Evidence IMP] [PMID 16107558]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IMP,IPI] [PMID 11248049]; GO_process: GO:0030833 - regulation of actin filament polymerization [Evidence IEA]
AWJ20_4903	3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004648 - O-phospho-L-serine:2-oxoglutarate aminotransferase activity [Evidence IEA,IEA]; GO_function: GO:0004648 - O-phospho-L-serine:2-oxoglutarate aminotransferase activity [Evidence IMP,ISS] [PMID 8017107]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006564 - L-serine biosynthetic process [Evidence IMP,ISS] [PMID 8017107]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009113 - purine nucleobase biosynthetic process [Evidence IMP] [PMID 10509016]; GO_process: GO:0009070 - serine family amino acid biosynthetic process [Evidence IMP] [PMID 1326413]
AWJ20_4905	Methyltransferase; methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 18332120]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 9873020]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016435 - rRNA (guanine) methyltransferase activity [Evidence IMP] [PMID 18332120]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 18332120]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0070476 - rRNA (guanine-N7)-methylation [Evidence IMP] [PMID 18332120]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 18332120]
AWJ20_4906	Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence TAS] [PMID 11717306]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence IDA] [PMID 16774922]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
AWJ20_4908	Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12869188]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 10848624]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12869188]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 17803462]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA] [PMID 10848624]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IGI] [PMID 10848624]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IGI] [PMID 16126894]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0045717 - negative regulation of fatty acid biosynthetic process [Evidence IDA,IGI,IMP] [PMID 17803462]; GO_process: GO:1901352 - negative regulation of phosphatidylglycerol biosynthetic process [Evidence IGI] [PMID 12869188]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IGI] [PMID 16262726]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 10848624]; GO_process: GO:2001247 - positive regulation of phosphatidylcholine biosynthetic process [Evidence IGI] [PMID 12869188]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4909	Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3; GO_component: GO:0030123 - AP-3 adaptor complex [Evidence IMP] [PMID 9250663]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA,IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10559961]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 9335339]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 17895371]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_4910	Protein that stimulates strand exchange; stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 12766777]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11459964]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0000150 - recombinase activity [Evidence IDA] [PMID 15205482]; GO_process: GO:0006277 - DNA amplification [Evidence IMP] [PMID 23271978]; GO_process: GO:0000730 - DNA recombinase assembly [Evidence IDA] [PMID 11459983]; GO_process: GO:0006310 - DNA recombination [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 9619627]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 17096599]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 17096599]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 24190138]; GO_process: GO:0045002 - double-strand break repair via single-strand annealing [Evidence IGI] [PMID 11606529]; GO_process: GO:0000709 - meiotic joint molecule formation [Evidence IGI,IMP] [PMID 18313389]; GO_process: GO:0006301 - postreplication repair [Evidence IMP] [PMID 7038396]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IMP] [PMID 11238918]
AWJ20_4911	Beta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IGI,IPI] [PMID 8336705]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IMP] [PMID 8441423]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IPI] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IPI] [PMID 8336705]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI] [PMID 8164676]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI,IPI] [PMID 8887689]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP] [PMID 9032257]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IPI] [PMID 8336705]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 8506384]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IGI,IPI] [PMID 8336705]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI] [PMID 8164676]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IPI] [PMID 8887689]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 9032257]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
AWJ20_4913	Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17710650]; GO_function: GO:0015144 - carbohydrate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015355 - secondary active monocarboxylate transmembrane transporter activity [Evidence IMP] [PMID 17710650]; GO_function: GO:0097079 - selenite:proton symporter activity [Evidence IMP] [PMID 20861301]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0034219 - carbohydrate transmembrane transport [Evidence IEA]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 10198029]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0006849 - plasma membrane pyruvate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0097080 - plasma membrane selenite transport [Evidence IMP] [PMID 20861301]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4914	Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17710650]; GO_function: GO:0015144 - carbohydrate transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015355 - secondary active monocarboxylate transmembrane transporter activity [Evidence IMP] [PMID 17710650]; GO_function: GO:0097079 - selenite:proton symporter activity [Evidence IMP] [PMID 20861301]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_process: GO:0034219 - carbohydrate transmembrane transport [Evidence IEA]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 10198029]; GO_process: GO:0035879 - plasma membrane lactate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0006849 - plasma membrane pyruvate transport [Evidence IMP] [PMID 17710650]; GO_process: GO:0097080 - plasma membrane selenite transport [Evidence IMP] [PMID 20861301]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4916	Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in its human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 17934474]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720285]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 17934474]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17934474]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0030619 - U1 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0030620 - U2 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IEA]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IDA] [PMID 9848662]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IEA]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0097157 - pre-mRNA intronic binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 17626844]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 22408182]; GO_process: GO:0000389 - mRNA 3'-splice site recognition [Evidence IMP] [PMID 10628969]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IMP] [PMID 17934474]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IDA] [PMID 23393194]
AWJ20_4917	Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in its human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 17934474]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720285]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 17934474]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 17934474]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0030619 - U1 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0030620 - U2 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IEA]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0030623 - U5 snRNA binding [Evidence IDA] [PMID 9848662]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IEA]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0097157 - pre-mRNA intronic binding [Evidence IDA] [PMID 23393194]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IMP] [PMID 17626844]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 22408182]; GO_process: GO:0000389 - mRNA 3'-splice site recognition [Evidence IMP] [PMID 10628969]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IMP] [PMID 17934474]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IDA] [PMID 23393194]
AWJ20_4918	Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10913188]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8065366]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 21075847]; GO_process: GO:0031144 - proteasome localization [Evidence IEA]; GO_process: GO:0031144 - proteasome localization [Evidence IMP] [PMID 21075847]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4919	Threonyl-tRNA synthetase; essential cytoplasmic protein; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 2995918]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence ISA] [PMID 2995918]; GO_function: GO:0004829 - threonine-tRNA ligase activity [Evidence IDA] [PMID 8143729]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 10471698]; GO_process: GO:0043039 - tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006435 - threonyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006435 - threonyl-tRNA aminoacylation [Evidence ISA] [PMID 2995918]; GO_process: GO:0006435 - threonyl-tRNA aminoacylation [Evidence IDA] [PMID 8143729]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4920	WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus; GO_component: GO:0070210 - Rpd3L-Expanded complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9651685]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0031939 - negative regulation of chromatin silencing at telomere [Evidence IMP,IPI] [PMID 9651685]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IPI] [PMID 11711434]; GO_process: GO:0032874 - positive regulation of stress-activated MAPK cascade [Evidence IMP] [PMID 18487345]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 19379692]
AWJ20_4921	Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10438536]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 10438536]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0000145 - exocyst [Evidence IDA] [PMID 10438536]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10438536]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0030133 - transport vesicle [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 10438536]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 15788396]; GO_process: GO:0001927 - exocyst assembly [Evidence IMP] [PMID 15788396]; GO_process: GO:0051601 - exocyst localization [Evidence IMP] [PMID 15788396]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IGI,IMP] [PMID 10438536]; GO_process: GO:0006887 - exocytosis [Evidence IMP] [PMID 15788396]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IMP,IPI] [PMID 11425851]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0090522 - vesicle tethering involved in exocytosis [Evidence IC] [PMID 10438536]
AWJ20_4922	Non-essential sumoylated hypothetical protein; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4923	Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004632 - phosphopantothenate--cysteine ligase activity [Evidence IEA]; GO_function: GO:0004632 - phosphopantothenate--cysteine ligase activity [Evidence ISS] [PMID 11923312]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 11923312]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]
AWJ20_4924	Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8413212]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8413213]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 23222640]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8413212]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15964806]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IMP] [PMID 8413212]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IMP] [PMID 8413213]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008266 - poly(U) RNA binding [Evidence IDA] [PMID 8413213]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IDA] [PMID 10892745]; GO_process: GO:0043488 - regulation of mRNA stability [Evidence IMP] [PMID 15964806]; GO_process: GO:0034063 - stress granule assembly [Evidence IMP] [PMID 18981231]
AWJ20_4925	Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 1429680]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15635103]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15635103]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 1429680]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA] [PMID 1429680]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA] [PMID 2050695]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_4926	Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004370 - glycerol kinase activity [Evidence IEA,IEA]; GO_function: GO:0004370 - glycerol kinase activity [Evidence IMP,ISS] [PMID 8358828]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0019563 - glycerol catabolic process [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA]; GO_process: GO:0006071 - glycerol metabolic process [Evidence TAS] [PMID 8358828]; GO_process: GO:0006072 - glycerol-3-phosphate metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4931	Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 20485265]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008962 - phosphatidylglycerophosphatase activity [Evidence IEA]; GO_function: GO:0008962 - phosphatidylglycerophosphatase activity [Evidence IDA,IGI,IMP] [PMID 20485265]; GO_process: GO:0032049 - cardiolipin biosynthetic process [Evidence IMP] [PMID 20485265]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006655 - phosphatidylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0046838 - phosphorylated carbohydrate dephosphorylation [Evidence IMP] [PMID 20485265]
AWJ20_4934	Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]
AWJ20_4935	D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10094636]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003885 - D-arabinono-1,4-lactone oxidase activity [Evidence IEA,IEA]; GO_function: GO:0003885 - D-arabinono-1,4-lactone oxidase activity [Evidence IDA] [PMID 10094636]; GO_function: GO:0008762 - UDP-N-acetylmuramate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors [Evidence IEA]; GO_function: GO:0016899 - oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 10094636]; GO_process: GO:0070485 - dehydro-D-arabinono-1,4-lactone biosynthetic process [Evidence IMP] [PMID 10094636]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4938	Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs); GO_component: GO:0005686 - U2 snRNP [Evidence TAS] [PMID 11804584]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IMP,ISS] [PMID 9710584]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI,IPI] [PMID 9710584]
AWJ20_4939	Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs); GO_component: GO:0005686 - U2 snRNP [Evidence TAS] [PMID 11804584]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IMP,ISS] [PMID 9710584]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI,IPI] [PMID 9710584]
AWJ20_4940	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11171066]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12562762]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0000297 - spermine transmembrane transporter activity [Evidence IMP] [PMID 11171066]; GO_process: GO:0000296 - spermine transport [Evidence IMP] [PMID 11171066]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4944	Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex; GO_component: GO:0031463 - Cul3-RING ubiquitin ligase complex [Evidence IDA] [PMID 16675952]; GO_component: GO:0000113 - nucleotide-excision repair factor 4 complex [Evidence IDA] [PMID 9497356]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 9497356]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 9497356]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 16675952]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000715 - nucleotide-excision repair, DNA damage recognition [Evidence IDA,IMP] [PMID 15177043]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16675952]
AWJ20_4946	Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003939 - L-iditol 2-dehydrogenase activity [Evidence IEA]; GO_function: GO:0003939 - L-iditol 2-dehydrogenase activity [Evidence IDA,ISS] [PMID 8125328]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEP] [PMID 8125328]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4948	Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15470103]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8909536]; GO_component: GO:0045009 - chitosome [Evidence IDA] [PMID 8970154]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9008706]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15470103]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9008706]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 15755916]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IMP] [PMID 9760183]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 1293886]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence TAS] [PMID 7565410]
AWJ20_4949	Uridine nucleosidase (uridine-cytidine N-ribohydrolase); cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0016799 - hydrolase activity, hydrolyzing N-glycosyl compounds [Evidence IEA]; GO_function: GO:0070635 - nicotinamide riboside hydrolase activity [Evidence IDA] [PMID 19001417]; GO_function: GO:0070636 - nicotinic acid riboside hydrolase activity [Evidence IDA] [PMID 19001417]; GO_function: GO:0050263 - ribosylpyrimidine nucleosidase activity [Evidence IDA] [PMID 11872485]; GO_function: GO:0050263 - ribosylpyrimidine nucleosidase activity [Evidence IDA] [PMID 12111094]; GO_function: GO:0045437 - uridine nucleosidase activity [Evidence IEA]; GO_function: GO:0045437 - uridine nucleosidase activity [Evidence IDA] [PMID 19001417]; GO_process: GO:0034356 - NAD biosynthesis via nicotinamide riboside salvage pathway [Evidence IGI] [PMID 19001417]; GO_process: GO:0006216 - cytidine catabolic process [Evidence IMP] [PMID 23670538]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019358 - nicotinate nucleotide salvage [Evidence IGI] [PMID 17482543]; GO_process: GO:0046135 - pyrimidine nucleoside catabolic process [Evidence IDA] [PMID 11872485]; GO_process: GO:0046135 - pyrimidine nucleoside catabolic process [Evidence IDA] [PMID 12111094]; GO_process: GO:0008655 - pyrimidine-containing compound salvage [Evidence IMP] [PMID 11872485]; GO_process: GO:0006218 - uridine catabolic process [Evidence IMP] [PMID 23670538]
AWJ20_4950	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IDA] [PMID 20308326]; GO_function: GO:0001128 - RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Evidence IDA] [PMID 8378310]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IMP] [PMID 15254252]; GO_function: GO:0001088 - TFIIE-class binding transcription factor activity [Evidence IDA] [PMID 8790357]; GO_function: GO:0001095 - TFIIE-class transcription factor binding [Evidence IDA] [PMID 8790357]; GO_function: GO:0001097 - TFIIH-class transcription factor binding [Evidence IDA] [PMID 10973956]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IDA] [PMID 12482986]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11470794]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8187178]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9891034]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4951	Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11427713]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11781332]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20035756]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005227 - calcium activated cation channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005262 - calcium channel activity [Evidence IEA]; GO_function: GO:0005262 - calcium channel activity [Evidence IDA] [PMID 11781332]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005267 - potassium channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005272 - sodium channel activity [Evidence IDA] [PMID 1700419]; GO_function: GO:0005244 - voltage-gated ion channel activity [Evidence IDA] [PMID 1700419]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IDA,IMP] [PMID 11427713]; GO_process: GO:0030003 - cellular cation homeostasis [Evidence IDA,IMP] [PMID 11781332]; GO_process: GO:0006811 - ion transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4952	Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_4954	Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; GO_component: GO:0005829 - cytosol [Evidence IPI] [PMID 9234705]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 9234705]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7621831]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006448 - regulation of translational elongation [Evidence IMP,IPI] [PMID 9234705]
AWJ20_4955	Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; has similarity to E. coli RNase R and to human DIS3; mutations in Dis3p corresponding to human mutations implicated in multiple myeloma cause phenotypes suggesting impaired exosome function; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9562621]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IDA,IMP] [PMID 17173052]; GO_function: GO:0000175 - 3'-5'-exoribonuclease activity [Evidence IDA,IMP] [PMID 17643380]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA,IMP] [PMID 19060886]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 19060898]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA,IMP] [PMID 19129231]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA,IMP] [PMID 17643380]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9390555]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IMP] [PMID 11352936]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 19481524]; GO_process: GO:0071028 - nuclear mRNA surveillance [Evidence IMP] [PMID 11030620]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IMP] [PMID 15935759]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IC] [PMID 10465791]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 16431988]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18940861]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IGI] [PMID 15145828]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA,IMP] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 10508172]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_4956	Ski complex component and WD-repeat protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype; GO_component: GO:0055087 - Ski complex [Evidence IDA] [PMID 10744028]; GO_component: GO:0055087 - Ski complex [Evidence IDA,IPI] [PMID 18042677]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000228 - nuclear chromosome [Evidence IDA] [PMID 14992724]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0051607 - defense response to virus [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IMP] [PMID 9482746]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 11910110]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IMP] [PMID 17660569]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 14992724]; GO_process: GO:0065004 - protein-DNA complex assembly [Evidence IMP] [PMID 14992724]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI,IMP,IPI] [PMID 14992724]
AWJ20_4957	Splicing factor; component of the U4/U6-U5 snRNP complex; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]
AWJ20_4958	ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; the Isw2 complex exhibits basal levels of chromatin binding throughout the genome as well as target-specific chromatin interactions; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide; GO_component: GO:0008623 - CHRAC [Evidence IPI,ISS] [PMID 14673157]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11238381]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 19203228]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 16227570]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0031491 - nucleosome binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 19203228]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IMP] [PMID 11238381]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA,IMP] [PMID 16227570]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 17689493]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 14673157]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 17689493]; GO_process: GO:0060195 - negative regulation of antisense RNA transcription [Evidence IGI] [PMID 18075583]; GO_process: GO:0046020 - negative regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IMP] [PMID 12624196]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 15116071]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 17949749]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 16227570]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IGI] [PMID 12504018]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4959	Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 2203793]; GO_function: GO:1901235 - (R)-carnitine transmembrane transporter activity [Evidence IMP] [PMID 23755272]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IMP] [PMID 2203793]; GO_function: GO:0015220 - choline transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_function: GO:0034228 - ethanolamine transmembrane transporter activity [Evidence IGI] [PMID 3514579]; GO_process: GO:1900749 - (R)-carnitine transport [Evidence IMP] [PMID 23755272]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015871 - choline transport [Evidence IMP] [PMID 2203793]; GO_process: GO:0015871 - choline transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0034229 - ethanolamine transport [Evidence IGI] [PMID 3514579]; GO_process: GO:0031460 - glycine betaine transport [Evidence IMP] [PMID 16487344]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4960	One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 16824951]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 20647997]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016459 - myosin complex [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000146 - microfilament motor activity [Evidence IDA] [PMID 16824951]; GO_function: GO:0003774 - motor activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IGI,IMP] [PMID 18177206]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 10652251]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 16824951]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006898 - receptor-mediated endocytosis [Evidence IMP] [PMID 8614799]; GO_process: GO:0006970 - response to osmotic stress [Evidence TAS] [PMID 10652251]; GO_process: GO:0009651 - response to salt stress [Evidence IGI,IPI] [PMID 12391157]
AWJ20_4963	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; GO_component: GO:0031251 - PAN complex [Evidence IDA] [PMID 8816488]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004535 - poly(A)-specific ribonuclease activity [Evidence IDA,IMP] [PMID 8816488]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 11953437]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IMP,IPI] [PMID 8816488]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006301 - postreplication repair [Evidence IGI,IPI] [PMID 11953437]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]
AWJ20_4964	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 3004948]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 6290489]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004460 - L-lactate dehydrogenase (cytochrome) activity [Evidence IDA] [PMID 3004948]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006089 - lactate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_4965	TFIID subunit (40 kDa); involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10818000]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 12840001]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9083082]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4966	Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 22553352]; GO_component: GO:0035339 - SPOTS complex [Evidence IDA] [PMID 20182505]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA,IMP] [PMID 15657391]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 8314848]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,IMP] [PMID 11514624]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IMP] [PMID 11792713]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,IMP] [PMID 15657391]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 8314848]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016791 - phosphatase activity [Evidence IMP] [PMID 22452743]; GO_function: GO:0043813 - phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0043812 - phosphatidylinositol-4-phosphate phosphatase activity [Evidence IDA] [PMID 10625610]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA,IGI,IMP] [PMID 10625610]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 22553352]
AWJ20_4967	Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
AWJ20_4968	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4969	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; GO_component: GO:0005619 - ascospore wall [Evidence IDA] [PMID 8636217]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 1934633]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 18826657]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 8791410]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0072687 - meiotic spindle [Evidence IDA] [PMID 18826657]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 18826657]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 18826657]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IC] [PMID 10882120]; GO_process: GO:0000281 - mitotic cytokinesis [Evidence IMP] [PMID 4950437]; GO_process: GO:0045860 - positive regulation of protein kinase activity [Evidence IDA] [PMID 14527412]
AWJ20_4971	Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IEA,IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 11926067]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0009353 - mitochondrial oxoglutarate dehydrogenase complex [Evidence IDA] [PMID 2072900]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016624 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Evidence IEA]; GO_function: GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity [Evidence IEA,IEA]; GO_function: GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity [Evidence TAS] [PMID 9175438]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_process: GO:0006103 - 2-oxoglutarate metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
AWJ20_4975	Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 12857851]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_function: GO:0051015 - actin filament binding [Evidence IDA] [PMID 12857851]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 12857851]; GO_process: GO:0007015 - actin filament organization [Evidence IDA] [PMID 12857851]; GO_process: GO:0001300 - chronological cell aging [Evidence IGI,IMP] [PMID 15024029]
AWJ20_4977	Mitochondrial DNA polymerase gamma subunit; conserved C-terminal segment is required for the maintenance of mitochondrial genome; its human ortholog, POLG, can rescue mip1 phenotypes, and mutations in POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit; GO_component: GO:0005760 - gamma DNA polymerase complex [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10567545]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008408 - 3'-5' exonuclease activity [Evidence IDA] [PMID 20601675]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 20601675]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA]; GO_process: GO:0006264 - mitochondrial DNA replication [Evidence IDA] [PMID 12023279]; GO_process: GO:0006264 - mitochondrial DNA replication [Evidence IMP] [PMID 2684980]
AWJ20_4979	hypothetical protein required for oxidative damage resistance; required for normal levels of resistance to oxidative damage; null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 15060142]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11114193]
AWJ20_4980	Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IMP] [PMID 3552672]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015175 - neutral amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IDA,IGI] [PMID 8455553]; GO_process: GO:0015804 - neutral amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0015824 - proline transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_4981	Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IMP] [PMID 3552672]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015175 - neutral amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IDA,IGI] [PMID 8455553]; GO_process: GO:0015804 - neutral amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0015824 - proline transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_4983	RNA polymerase I subunit A43; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 11486042]; GO_component: GO:0005736 - DNA-directed RNA polymerase I complex [Evidence IDA] [PMID 9837969]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001054 - RNA polymerase I activity [Evidence IDA] [PMID 9837969]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IDA] [PMID 9837969]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IGI] [PMID 7592632]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4984	Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins; GO_component: GO:0030896 - checkpoint clamp complex [Evidence IEA]; GO_component: GO:0030896 - checkpoint clamp complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0030896 - checkpoint clamp complex [Evidence IDA] [PMID 9891048]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 11356855]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 12604797]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 9564050]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 17624540]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10511543]
AWJ20_4985	Protein required for cvt-vesicle/autophagosome fusion with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate; GO_component: GO:0035658 - Mon1-Ccz1 complex [Evidence IPI] [PMID 20797862]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12387888]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 12364329]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0032585 - multivesicular body membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0006914 - autophagy [Evidence IMP] [PMID 12387888]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12134085]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048278 - vesicle docking [Evidence IMP] [PMID 14662743]
AWJ20_4986	ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly; GO_component: GO:0070209 - ASTRA complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0097255 - R2TP complex [Evidence IDA] [PMID 15766533]; GO_component: GO:0097255 - R2TP complex [Evidence IPI] [PMID 18268103]; GO_component: GO:0000812 - Swr1 complex [Evidence IPI] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IPI] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence IDA] [PMID 22100294]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11604509]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 20553504]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 18234224]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 11604509]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 18268103]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 14690608]; GO_process: GO:0043486 - histone exchange [Evidence IPI] [PMID 14645854]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11604509]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11278922]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_4989	Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 14562095]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
AWJ20_4990	Mitochondrial ribosomal protein of the small subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24390141]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_4991	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_4992	Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 12181333]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 16251346]; GO_function: GO:0008157 - protein phosphatase 1 binding [Evidence IDA] [PMID 12356757]; GO_function: GO:0008157 - protein phosphatase 1 binding [Evidence IPI] [PMID 8754819]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 12356757]; GO_process: GO:0030866 - cortical actin cytoskeleton organization [Evidence IMP] [PMID 12181333]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 16251346]; GO_process: GO:0009306 - protein secretion [Evidence IGI,IMP] [PMID 8688556]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_4994	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 5571830]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003985 - acetyl-CoA C-acetyltransferase activity [Evidence IEA]; GO_function: GO:0003985 - acetyl-CoA C-acetyltransferase activity [Evidence IDA] [PMID 7989303]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_4996	Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at the plasma membrane; recruited to the plasma membrane via a conserved basic patch near its N-terminus; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19075114]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0090002 - establishment of protein localization to plasma membrane [Evidence IMP] [PMID 19075114]
AWJ20_4998	Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_4999	Nucleolar protein; forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030692 - Noc4p-Nop14p complex [Evidence IPI] [PMID 12446671]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12446671]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 12446671]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 12446671]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
AWJ20_5000	Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031305 - integral component of mitochondrial inner membrane [Evidence IDA] [PMID 12411483]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0015234 - thiamine transmembrane transporter activity [Evidence IDA] [PMID 12411483]; GO_process: GO:0030974 - thiamine pyrophosphate transport [Evidence IDA,IMP] [PMID 12411483]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5001	Glycosylated integral ER membrane hypothetical protein; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 23275891]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 19325107]
AWJ20_5002	P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 11791712]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 12058017]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 22745129]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence IDA] [PMID 12058017]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence IDA] [PMID 22745129]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 12058017]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IMP] [PMID 24392018]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055092 - sterol homeostasis [Evidence IMP] [PMID 22918956]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 12058017]
AWJ20_5004	Subunit of both RNase MRP and nuclear RNase P; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IDA] [PMID 9618478]; GO_component: GO:0005655 - nucleolar ribonuclease P complex [Evidence IDA] [PMID 9620854]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IPI] [PMID 17881380]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IMP] [PMID 9618478]; GO_component: GO:0000172 - ribonuclease MRP complex [Evidence IDA] [PMID 9620854]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000171 - ribonuclease MRP activity [Evidence IDA,IMP] [PMID 9620854]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IEA]; GO_function: GO:0004526 - ribonuclease P activity [Evidence IDA,IMP] [PMID 9620854]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0034965 - intronic box C/D snoRNA processing [Evidence IDA] [PMID 18713869]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 14729943]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9618478]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 9620854]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9618478]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9620854]
AWJ20_5005	XP_962611|transcriptional activator xlnR [Neurospora crassa OR74A]
AWJ20_5011	Rab family GTPase; essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; GO_component: GO:0030478 - actin cap [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 9128251]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0030133 - transport vesicle [Evidence TAS] [PMID 12665530]; GO_component: GO:0030133 - transport vesicle [Evidence IDA] [PMID 23079598]; GO_component: GO:0030658 - transport vesicle membrane [Evidence IEA]; GO_component: GO:0031982 - vesicle [Evidence IDA] [PMID 12456647]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 2111819]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 2111819]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006893 - Golgi to plasma membrane transport [Evidence IMP] [PMID 9017592]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IMP] [PMID 9425151]; GO_process: GO:0006914 - autophagy [Evidence IGI,IMP] [PMID 20444978]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 10652251]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0006887 - exocytosis [Evidence IDA] [PMID 15772160]; GO_process: GO:0007107 - membrane addition at site of cytokinesis [Evidence IEP,IGI,IMP] [PMID 12456647]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence TAS] [PMID 10652251]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IMP] [PMID 9017592]
AWJ20_5012	Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0009328 - phenylalanine-tRNA ligase complex [Evidence IDA] [PMID 3049607]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 16162501]; GO_function: GO:0004826 - phenylalanine-tRNA ligase activity [Evidence IDA] [PMID 166841]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 16162501]; GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation [Evidence IDA] [PMID 166841]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_5015	Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10207098]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10207098]; GO_function: GO:0051087 - chaperone binding [Evidence IMP,IPI] [PMID 9632755]; GO_process: GO:0043392 - negative regulation of DNA binding [Evidence IDA] [PMID 23022381]; GO_process: GO:0032212 - positive regulation of telomere maintenance via telomerase [Evidence IDA,IMP] [PMID 17389357]; GO_process: GO:0006457 - protein folding [Evidence IMP,IPI] [PMID 9632755]; GO_process: GO:0051972 - regulation of telomerase activity [Evidence IDA,IMP] [PMID 17389357]
AWJ20_5016	hypothetical protein that associates with translating ribosomes; interacts with GTPase Rbg1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0042788 - polysomal ribosome [Evidence IDA] [PMID 21076151]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IGI] [PMID 21076151]
AWJ20_5017	Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11687631]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11742990]; GO_component: GO:0048188 - Set1C/COMPASS complex [Evidence IPI] [PMID 11752412]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA] [PMID 11742990]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IMP] [PMID 11752412]; GO_function: GO:0042800 - histone methyltransferase activity (H3-K4 specific) [Evidence IDA,IMP] [PMID 11805083]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11687631]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11752412]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11805083]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA] [PMID 11742990]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11752412]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IDA,IMP] [PMID 11805083]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 11742990]
AWJ20_5020	Putative amidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004040 - amidase activity [Evidence IEA]; GO_function: GO:0004040 - amidase activity [Evidence ISS] [PMID 2263500]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
AWJ20_5021	Coproporphyrinogen III oxidase; an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 3516695]; GO_function: GO:0004109 - coproporphyrinogen oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004109 - coproporphyrinogen oxidase activity [Evidence IMP] [PMID 2838478]; GO_function: GO:0004109 - coproporphyrinogen oxidase activity [Evidence IDA] [PMID 3516695]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IEA]; GO_process: GO:0006783 - heme biosynthetic process [Evidence IMP] [PMID 7035824]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006782 - protoporphyrinogen IX biosynthetic process [Evidence IEA]
AWJ20_5022	Methyltransferase required for m3U2634 methylation of the 25S rRNA; S-adenosylmethionine-dependent; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 24335083]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA,ISS] [PMID 21858014]; GO_function: GO:0070042 - rRNA (uridine-N3-)-methyltransferase activity [Evidence IMP] [PMID 24335083]; GO_process: GO:0032259 - methylation [Evidence IC] [PMID 21858014]; GO_process: GO:0070475 - rRNA base methylation [Evidence IMP] [PMID 24335083]
AWJ20_5023	Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 22044534]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IMP] [PMID 18355271]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]
AWJ20_5024	Protein required for the hydroxylation of heme O to form heme A; heme A is an essential prosthetic group for cytochrome c oxidase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9228094]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0016653 - oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Evidence IMP] [PMID 11248251]; GO_function: GO:0016653 - oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Evidence IGI] [PMID 11788607]; GO_function: GO:0016627 - oxidoreductase activity, acting on the CH-CH group of donors [Evidence IEA]; GO_process: GO:0006784 - heme a biosynthetic process [Evidence IEA]; GO_process: GO:0006784 - heme a biosynthetic process [Evidence IGI,IMP] [PMID 11788607]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_5025	ER membrane hypothetical protein; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISM] [PMID 23275891]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 19325107]
AWJ20_5029	Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 24706893]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 24706893]; GO_function: GO:0019172 - glyoxalase III activity [Evidence IDA] [PMID 24302734]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031669 - cellular response to nutrient levels [Evidence IMP] [PMID 24706893]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17395014]; GO_process: GO:0019243 - methylglyoxal catabolic process to D-lactate [Evidence IDA] [PMID 24302734]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_5030	Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10400670]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IGI,IMP,ISS] [PMID 10400670]; GO_function: GO:0015095 - magnesium ion transmembrane transporter activity [Evidence IDA] [PMID 12628916]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015693 - magnesium ion transport [Evidence IEA]; GO_process: GO:0045016 - mitochondrial magnesium ion transport [Evidence IGI,IMP,ISS] [PMID 10400670]; GO_process: GO:0045016 - mitochondrial magnesium ion transport [Evidence IDA] [PMID 12628916]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5031	Aurora kinase of conserved chromosomal passenger complex; mediates release on mono-oriented kinetochores from microtubules in meiosis I, also release of kinetochores from cluster at SPBs at meiosis exit; helps maintain condensed chromosomes during anaphase, early telophase; required for SPB cohesion and prevention of multipolar spindle formation; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0032133 - chromosome passenger complex [Evidence IDA] [PMID 19158380]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA]; GO_component: GO:0000777 - condensed chromosome kinetochore [Evidence IEA]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 11511347]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 12566427]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IDA] [PMID 11724818]; GO_component: GO:0005874 - microtubule [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005819 - spindle [Evidence IDA] [PMID 12566427]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11511347]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11724818]; GO_component: GO:0051233 - spindle midzone [Evidence IDA] [PMID 12566427]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 10072382]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16143104]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 23142046]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0008608 - attachment of spindle microtubules to kinetochore [Evidence IMP] [PMID 10072382]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 8293973]; GO_process: GO:0045143 - homologous chromosome segregation [Evidence IMP] [PMID 17289568]; GO_process: GO:0045144 - meiotic sister chromatid segregation [Evidence IMP] [PMID 17289568]; GO_process: GO:0045144 - meiotic sister chromatid segregation [Evidence IMP] [PMID 17371833]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IGI] [PMID 16651657]; GO_process: GO:0051228 - mitotic spindle disassembly [Evidence IMP] [PMID 12566427]; GO_process: GO:1901925 - negative regulation of protein import into nucleus during spindle assembly checkpoint [Evidence IMP] [PMID 23177738]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0090232 - positive regulation of spindle checkpoint [Evidence IMP] [PMID 16327780]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA,IMP] [PMID 17504936]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 23142046]; GO_process: GO:0032465 - regulation of cytokinesis [Evidence IMP] [PMID 16615892]
AWJ20_5033	Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 8841414]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8841414]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0050203 - oxalate-CoA ligase activity [Evidence IDA,IMP] [PMID 24291261]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0033611 - oxalate catabolic process [Evidence IDA,IMP] [PMID 24291261]
AWJ20_5034	Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable; ISU1 has a paralog, ISU2, that arose from the whole genome duplication; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10468587]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15143178]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA]; GO_function: GO:0008198 - ferrous iron binding [Evidence IDA] [PMID 12970193]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP,ISS] [PMID 10468587]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP,ISS] [PMID 10588895]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IGI] [PMID 12970193]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 15143178]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IGI] [PMID 17283054]
AWJ20_5035	Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15520468]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15520468]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0070692 - trimeric positive transcription elongation factor complex b [Evidence IDA] [PMID 7565723]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0031124 - mRNA 3'-end processing [Evidence IC] [PMID 11118453]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0032786 - positive regulation of DNA-templated transcription, elongation [Evidence IDA] [PMID 9110987]; GO_process: GO:0045943 - positive regulation of transcription from RNA polymerase I promoter [Evidence IMP] [PMID 15520468]; GO_process: GO:0045903 - positive regulation of translational fidelity [Evidence IPI] [PMID 17545469]; GO_process: GO:0006468 - protein phosphorylation [Evidence IPI] [PMID 7565723]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5036	Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 8982460]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008242 - omega peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 19410548]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_5037	3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17054397]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IEA]; GO_function: GO:0003860 - 3-hydroxyisobutyryl-CoA hydrolase activity [Evidence IDA,ISS] [PMID 12697341]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IMP] [PMID 12697341]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006574 - valine catabolic process [Evidence IEA]
AWJ20_5038	Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 16287850]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10692169]; GO_component: GO:0030684 - preribosome [Evidence IPI] [PMID 16287850]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IMP,ISS] [PMID 16287850]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 10692169]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP,IPI] [PMID 16287850]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA,IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 16287850]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5039	Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0030429 - kynureninase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0030429 - kynureninase activity [Evidence IMP] [PMID 12062417]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA,IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IEA]; GO_process: GO:0034354 - 'de novo' NAD biosynthetic process from tryptophan [Evidence IGI] [PMID 12062417]; GO_process: GO:0097053 - L-kynurenine catabolic process [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0043420 - anthranilate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0019805 - quinolinate biosynthetic process [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA,IEA]
AWJ20_5040	NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051538 - 3 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016040 - glutamate synthase (NADH) activity [Evidence IEA,IEA]; GO_function: GO:0016040 - glutamate synthase (NADH) activity [Evidence IDA,IMP] [PMID 7836314]; GO_function: GO:0015930 - glutamate synthase activity [Evidence IEA]; GO_function: GO:0045181 - glutamate synthase activity, NAD(P)H as acceptor [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016638 - oxidoreductase activity, acting on the CH-NH2 group of donors [Evidence IEA]; GO_function: GO:0016639 - oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0097054 - L-glutamate biosynthetic process [Evidence IEA]; GO_process: GO:0019676 - ammonia assimilation cycle [Evidence IEP] [PMID 11356843]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence IEP] [PMID 9657994]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_5041	Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_5043	eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0002188 - translation reinitiation [Evidence IMP] [PMID 20679478]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]
AWJ20_5044	Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008806 - carboxymethylenebutenolidase activity [Evidence IEA]; GO_function: GO:0008806 - carboxymethylenebutenolidase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
AWJ20_5045	allele of CaO19.8194
AWJ20_5047	Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 10037752]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 16034811]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 10037752]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 8991513]
AWJ20_5049	Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits, they have nonredundant roles in regulation of substrate specificity of the exosome; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15828860]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15935759]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11489916]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA,IGI] [PMID 15935759]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA] [PMID 15828860]; GO_process: GO:0071031 - nuclear mRNA surveillance of mRNA 3'-end processing [Evidence IGI] [PMID 17410208]; GO_process: GO:0071039 - nuclear polyadenylation-dependent CUT catabolic process [Evidence IGI] [PMID 18591258]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IGI] [PMID 15935758]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IGI] [PMID 18007593]; GO_process: GO:0071037 - nuclear polyadenylation-dependent snRNA catabolic process [Evidence IGI] [PMID 15935758]; GO_process: GO:0071036 - nuclear polyadenylation-dependent snoRNA catabolic process [Evidence IGI] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]
AWJ20_5050	Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_5052	hypothetical protein; null mutant displays sensitivity to DNA damaging agents; may have a role in lipid metabolism, based on localization to lipid droplets; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12077312]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_5053	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8B has a paralog, RPS8A, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 18782943]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IBA]
AWJ20_5054	Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1; GO_component: GO:0044695 - Dsc E3 ubiquitin ligase complex [Evidence IDA] [PMID 22681890]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 11788821]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP,ISS] [PMID 11788821]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 11788821]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IMP] [PMID 11788821]
AWJ20_5057	Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 7607232]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence ISA] [PMID 7607232]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence ISA] [PMID 7607232]; GO_process: GO:0070152 - mitochondrial isoleucyl-tRNA aminoacylation [Evidence IC] [PMID 7607232]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 7607232]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_5058	Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 7607232]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence ISA] [PMID 7607232]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence ISA] [PMID 7607232]; GO_process: GO:0070152 - mitochondrial isoleucyl-tRNA aminoacylation [Evidence IC] [PMID 7607232]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 7607232]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_5059	Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_5062	Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17179087]; GO_function: GO:0004044 - amidophosphoribosyltransferase activity [Evidence ISS] [PMID 17179087]; GO_function: GO:0003840 - gamma-glutamyltransferase activity [Evidence IDA,IMP] [PMID 22277648]; GO_function: GO:0008242 - omega peptidase activity [Evidence IGI] [PMID 17179087]; GO_function: GO:0008233 - peptidase activity [Evidence IGI] [PMID 17179087]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IMP] [PMID 17179087]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IDA,IMP] [PMID 22277648]
AWJ20_5064	Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IGI] [PMID 9528778]
AWJ20_5065	SUMO E3 ligase; catalyzes sumoylation of Yku70p/Yku80p and Sir4p promoting chromatin anchoring; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length; NFI1 has a paralog, SIZ1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16204216]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IDA] [PMID 12761287]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IMP] [PMID 23122649]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA,IMP] [PMID 23122649]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence TAS] [PMID 12402242]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 16204216]; GO_process: GO:0060969 - negative regulation of gene silencing [Evidence IMP] [PMID 22345352]; GO_process: GO:0016925 - protein sumoylation [Evidence IEA]; GO_process: GO:0016925 - protein sumoylation [Evidence IDA] [PMID 12761287]; GO_process: GO:0016925 - protein sumoylation [Evidence IMP] [PMID 22345352]; GO_process: GO:0016925 - protein sumoylation [Evidence IMP] [PMID 23122649]
AWJ20_5066	Alpha 2 subunit of the 20S proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_5067	Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004089 - carbonate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0004089 - carbonate dehydratase activity [Evidence IDA] [PMID 15096093]; GO_function: GO:0004089 - carbonate dehydratase activity [Evidence IDA] [PMID 15813743]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0015976 - carbon utilization [Evidence IEA]; GO_process: GO:0071244 - cellular response to carbon dioxide [Evidence IMP] [PMID 22253597]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 15096093]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
AWJ20_5069	Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 1761554]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IMP] [PMID 11157982]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IDA] [PMID 16413482]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IEA]; GO_function: GO:0015035 - protein disulfide oxidoreductase activity [Evidence IDA] [PMID 16002399]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16002399]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IEA]; GO_process: GO:0006662 - glycerol ether metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 11157982]
AWJ20_5070	hypothetical protein; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_5071	similar to Erwinia pyrifoliae Ep1/96 (NCBI:YP_002650176.1)
AWJ20_5073	Cell wall protein related to glucanases; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog, SIM1, that arose from the whole genome duplication; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11958935]; GO_component: GO:0005759 - mitochondrial matrix [Evidence TAS] [PMID 11958935]; GO_function: GO:0015926 - glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence TAS] [PMID 11958935]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]
AWJ20_5076	Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005854 - nascent polypeptide-associated complex [Evidence IDA] [PMID 10219998]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0070300 - phosphatidic acid binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0080025 - phosphatidylinositol-3,5-bisphosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA] [PMID 16343487]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 9482879]; GO_process: GO:0051083 - 'de novo' cotranslational protein folding [Evidence IPI] [PMID 10219998]; GO_process: GO:0006620 - posttranslational protein targeting to membrane [Evidence IGI] [PMID 10518932]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5077	Poly(A) binding protein; part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15630021]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15769879]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15630021]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15769879]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 8631901]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA,IMP] [PMID 9193001]; GO_function: GO:0008428 - ribonuclease inhibitor activity [Evidence IDA] [PMID 11889048]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IDA,IMP] [PMID 17766253]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA,IMP] [PMID 10357826]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5078	Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 15647753]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 15647753]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12504018]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12682017]; GO_component: GO:0030874 - nucleolar chromatin [Evidence IDA] [PMID 17259992]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 21623345]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IDA] [PMID 10811623]; GO_function: GO:0031490 - chromatin DNA binding [Evidence IDA] [PMID 12682017]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0035064 - methylated histone binding [Evidence IDA] [PMID 15647753]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0070615 - nucleosome-dependent ATPase activity [Evidence IDA] [PMID 10811623]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000182 - rDNA binding [Evidence IDA] [PMID 17259992]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 10811623]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0071894 - histone H2B conserved C-terminal lysine ubiquitination [Evidence IMP] [PMID 22549955]; GO_process: GO:2000104 - negative regulation of DNA-dependent DNA replication [Evidence IGI] [PMID 18245327]; GO_process: GO:0071441 - negative regulation of histone H3-K14 acetylation [Evidence IMP] [PMID 19948887]; GO_process: GO:2000616 - negative regulation of histone H3-K9 acetylation [Evidence IMP] [PMID 19948887]; GO_process: GO:1900050 - negative regulation of histone exchange [Evidence IMP] [PMID 22922743]; GO_process: GO:0042766 - nucleosome mobilization [Evidence IDA] [PMID 16606615]; GO_process: GO:0016584 - nucleosome positioning [Evidence IGI] [PMID 16468993]; GO_process: GO:0016584 - nucleosome positioning [Evidence IDA] [PMID 17949749]; GO_process: GO:1902275 - regulation of chromatin organization [Evidence IMP] [PMID 22922743]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IGI] [PMID 10811623]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 16468993]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001178 - regulation of transcriptional start site selection at RNA polymerase II promoter [Evidence IGI] [PMID 19948887]; GO_process: GO:0006363 - termination of RNA polymerase I transcription [Evidence IGI] [PMID 17259992]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IGI,IMP] [PMID 12504018]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI,IPI] [PMID 12682017]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5080	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10713161]; GO_function: GO:0016929 - SUMO-specific protease activity [Evidence IDA,IMP] [PMID 10713161]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA,IEA]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence ISS] [PMID 10094048]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IDA] [PMID 10713161]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0030261 - chromosome condensation [Evidence IMP] [PMID 11333221]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI,IMP] [PMID 10713162]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 10713161]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 11333221]; GO_process: GO:0016926 - protein desumoylation [Evidence IDA,IMP] [PMID 10713161]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
AWJ20_5081	Essential component of the TIM23 complex; tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex); TIM23 complex is short for the translocase of the inner mitochondrial membrane; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14517234]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14638855]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IEA]; GO_function: GO:0051087 - chaperone binding [Evidence IMP] [PMID 11344168]; GO_function: GO:0051087 - chaperone binding [Evidence IPI] [PMID 7809127]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP] [PMID 10824101]; GO_function: GO:0030674 - protein binding, bridging [Evidence IMP] [PMID 11344168]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 1396562]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 18400944]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5083	Putative dihydrokaempferol 4-reductase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence ISA] [PMID 19577617]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_5085	tRNA:pseudouridine synthase; introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9430663]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9430663]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 9430663]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 9430663]
AWJ20_5086	Putative ATP-dependent RNA helicase; nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients; GO_component: GO:0030686 - 90S preribosome [Evidence IDA,IPI] [PMID 21825077]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9769101]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 9769101]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 2408148]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:1902626 - assembly of large subunit precursor of preribosome [Evidence IMP] [PMID 22735702]; GO_process: GO:0000470 - maturation of LSU-rRNA [Evidence IMP] [PMID 2408148]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 21825077]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 2408148]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_5087	Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0019781 - NEDD8 activating enzyme activity [Evidence IMP,ISS] [PMID 9531531]; GO_function: GO:0019781 - NEDD8 activating enzyme activity [Evidence IDA,ISS] [PMID 9545234]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0045116 - protein neddylation [Evidence IEA]; GO_process: GO:0045116 - protein neddylation [Evidence ISS] [PMID 9531531]; GO_process: GO:0045116 - protein neddylation [Evidence IDA,IMP,ISS] [PMID 9545234]
AWJ20_5088	Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 16567426]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA,IMP] [PMID 18508919]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP,IPI] [PMID 18508919]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence IGI,IMP] [PMID 17606994]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IGI] [PMID 16874095]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IMP] [PMID 17606994]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IMP] [PMID 9545237]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IGI,IPI] [PMID 22492205]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI] [PMID 22492205]; GO_process: GO:0006457 - protein folding [Evidence IGI] [PMID 16874095]
AWJ20_5089	TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10818000]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5090	TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 10818000]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5091	Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis); GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 10319861]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 9753630]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IBA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0031301 - integral component of organelle membrane [Evidence IBA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015809 - arginine transport [Evidence IMP] [PMID 14660799]; GO_process: GO:0015819 - lysine transport [Evidence IMP] [PMID 14660799]; GO_process: GO:0051453 - regulation of intracellular pH [Evidence IMP] [PMID 10191121]; GO_process: GO:0051453 - regulation of intracellular pH [Evidence IMP] [PMID 10319861]; GO_process: GO:0051453 - regulation of intracellular pH [Evidence IMP] [PMID 16423829]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007034 - vacuolar transport [Evidence IBA]; GO_process: GO:0007033 - vacuole organization [Evidence IBA]
AWJ20_5092	Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11027267]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12150911]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11027267]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11996121]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 12150911]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_5094	Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 16135509]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042171 - lysophosphatidic acid acyltransferase activity [Evidence IDA] [PMID 20016004]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 16135509]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006642 - triglyceride mobilization [Evidence IDA,IMP] [PMID 16135509]
AWJ20_5095	Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 9023541]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 9459307]; GO_process: GO:0071470 - cellular response to osmotic stress [Evidence IEP] [PMID 9459307]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 9023541]; GO_process: GO:0006493 - protein O-linked glycosylation [Evidence IMP] [PMID 9813355]
AWJ20_5096	Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0043715 - 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity [Evidence IEA]; GO_function: GO:0043716 - 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity [Evidence IEA]; GO_function: GO:0043874 - acireductone synthase activity [Evidence IEA,IEA]; GO_function: GO:0043874 - acireductone synthase activity [Evidence ISS] [PMID 15102328]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0019284 - L-methionine biosynthetic process from S-adenosylmethionine [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA,IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]
AWJ20_5100	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16806052]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 9799224]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18504300]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_5101	Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 9674426]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IDA] [PMID 12446794]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 10788514]; GO_component: GO:0005669 - transcription factor TFIID complex [Evidence IDA] [PMID 15448131]; GO_function: GO:0001075 - RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly [Evidence IC] [PMID 15448131]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 12600943]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 11585915]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 10788514]; GO_process: GO:0016568 - chromatin modification [Evidence IDA] [PMID 9674426]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 9674426]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 12138208]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 15448131]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5102	High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10924521]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005375 - copper ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015088 - copper uptake transmembrane transporter activity [Evidence IDA] [PMID 10924521]; GO_process: GO:0015677 - copper ion import [Evidence IDA] [PMID 10924521]; GO_process: GO:0035434 - copper ion transmembrane transport [Evidence IEA]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5105	Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12388751]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12388751]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21536748]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12388751]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence ISA] [PMID 1656238]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000078 - cytokinesis after mitosis checkpoint [Evidence IGI] [PMID 20980617]; GO_process: GO:0001100 - negative regulation of exit from mitosis [Evidence IMP] [PMID 16314395]; GO_process: GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 21536748]; GO_process: GO:0061586 - positive regulation of transcription by transcription factor localization [Evidence IMP] [PMID 23275436]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 22581371]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 22814605]; GO_process: GO:0034504 - protein localization to nucleus [Evidence IMP] [PMID 23275436]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
AWJ20_5106	Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005751 - mitochondrial respiratory chain complex IV [Evidence IEA]; GO_component: GO:0005751 - mitochondrial respiratory chain complex IV [Evidence IPI] [PMID 1331058]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IEA,IEA]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IDA] [PMID 1331058]; GO_function: GO:0004129 - cytochrome-c oxidase activity [Evidence IDA] [PMID 7851399]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 10429195]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8395517]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0097250 - mitochondrial respiratory chain supercomplex assembly [Evidence IMP] [PMID 22342701]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006119 - oxidative phosphorylation [Evidence IEA]
AWJ20_5107	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; N-terminally propionylated in vivo; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005754 - mitochondrial proton-transporting ATP synthase, catalytic core [Evidence IDA] [PMID 17082766]; GO_component: GO:0005754 - mitochondrial proton-transporting ATP synthase, catalytic core [Evidence IMP,ISS] [PMID 2876995]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IEA,IEA]; GO_component: GO:0045261 - proton-transporting ATP synthase complex, catalytic core F(1) [Evidence IDA] [PMID 15294286]; GO_component: GO:0033178 - proton-transporting two-sector ATPase complex, catalytic domain [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15294286]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 18722382]; GO_function: GO:0016820 - hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IEA]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP] [PMID 1827117]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IDA] [PMID 20691145]; GO_function: GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism [Evidence IMP,ISS] [PMID 2876995]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence IEA]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0046034 - ATP metabolic process [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IEA]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IDA] [PMID 20691145]; GO_process: GO:0015986 - ATP synthesis coupled proton transport [Evidence IMP,ISS] [PMID 2876995]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5110	RNA polymerase III subunit C53; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IEA]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 1406624]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IEA]
AWJ20_5112	1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003841 - 1-acylglycerol-3-phosphate O-acyltransferase activity [Evidence IDA] [PMID 9212466]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA,IEA]; GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic process [Evidence IEA]; GO_process: GO:0046474 - glycerophospholipid biosynthetic process [Evidence IGI] [PMID 17675291]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
AWJ20_5113	Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0034317 - nicotinic acid riboside kinase activity [Evidence ISS] [PMID 17914902]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0050262 - ribosylnicotinamide kinase activity [Evidence IEA,IEA]; GO_function: GO:0050262 - ribosylnicotinamide kinase activity [Evidence IDA] [PMID 15137942]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0034356 - NAD biosynthesis via nicotinamide riboside salvage pathway [Evidence IGI] [PMID 15137942]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IEA]; GO_process: GO:0009435 - NAD biosynthetic process [Evidence IGI] [PMID 17914902]; GO_process: GO:0019359 - nicotinamide nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0046495 - nicotinamide riboside metabolic process [Evidence IDA,IGI] [PMID 15137942]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]
AWJ20_5115	Protein that binds to Fpr1p; confers rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10998178]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 10998178]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5117	Essential chromatin-associated protein; involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins; required to stabilize the catalytic subunit of DNA polymerase-alpha; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11168584]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 13680157]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9154825]; GO_component: GO:0005657 - replication fork [Evidence IMP] [PMID 15494305]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 10783164]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 15494305]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 19605346]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 16675460]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 19605346]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 10783164]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP,IPI] [PMID 9154825]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IGI,IMP] [PMID 10783164]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IGI,IMP] [PMID 11168584]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 9154825]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP,IPI] [PMID 16085704]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP,IPI] [PMID 16328881]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP,IPI] [PMID 16085704]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]
AWJ20_5118	Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress; GO_component: GO:0071944 - cell periphery [Evidence IDA] [PMID 12869188]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 16262726]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12869188]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19477927]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19477927]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA] [PMID 10848624]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IGI] [PMID 10848624]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IGI] [PMID 16262726]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 10848624]; GO_process: GO:2000114 - regulation of establishment of cell polarity [Evidence IGI] [PMID 19477927]; GO_process: GO:0017157 - regulation of exocytosis [Evidence IGI] [PMID 19477927]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5120	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IEA]; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IDA,IPI] [PMID 2832951]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 7828851]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 2832951]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 2832951]; GO_process: GO:0043457 - regulation of cellular respiration [Evidence IMP] [PMID 2182199]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5121	Similar to Conserved oligomeric Golgi complex subunit 1; acc. no. Q9VGC3
AWJ20_5122	Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051903 - S-(hydroxymethyl)glutathione dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0051903 - S-(hydroxymethyl)glutathione dehydrogenase activity [Evidence IDA] [PMID 8483449]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IMP] [PMID 12499363]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 8483449]; GO_function: GO:0033833 - hydroxymethylfurfural reductase (NADH) activity [Evidence IMP] [PMID 16652391]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006069 - ethanol oxidation [Evidence IEA]; GO_process: GO:0046294 - formaldehyde catabolic process [Evidence IDA] [PMID 8483449]; GO_process: GO:0033859 - furaldehyde metabolic process [Evidence IMP] [PMID 16652391]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_5123	Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 22678362]
AWJ20_5124	Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IPI] [PMID 9554851]; GO_component: GO:0042555 - MCM complex [Evidence IEA]; GO_component: GO:0042555 - MCM complex [Evidence IDA] [PMID 12480933]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10704410]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10704410]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 12480933]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11756674]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9554851]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0017116 - single-stranded DNA-dependent ATP-dependent DNA helicase activity [Evidence IDA] [PMID 18657510]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 12060653]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IMP] [PMID 19064704]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 19064704]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IMP] [PMID 20516198]; GO_process: GO:0033260 - nuclear cell cycle DNA replication [Evidence IMP] [PMID 10834843]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IPI] [PMID 9335335]
AWJ20_5125	Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15611069]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 15611069]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008941 - nitric oxide dioxygenase activity [Evidence IEA]; GO_function: GO:0016966 - nitric oxide reductase activity [Evidence IMP] [PMID 10758168]; GO_function: GO:0016966 - nitric oxide reductase activity [Evidence IMP] [PMID 15611069]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0019825 - oxygen binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IDA] [PMID 8810268]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IDA] [PMID 9545281]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015671 - oxygen transport [Evidence IEA]; GO_process: GO:0009636 - response to toxic substance [Evidence IEA]
AWJ20_5126	Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs; GO_component: GO:0000506 - glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [Evidence IGI,ISA] [PMID 9729469]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 8910381]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0017176 - phosphatidylinositol N-acetylglucosaminyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0017176 - phosphatidylinositol N-acetylglucosaminyltransferase activity [Evidence IC] [PMID 9729469]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IDA,IMP] [PMID 8910381]
AWJ20_5127	Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 9395539]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005458 - GDP-mannose transmembrane transporter activity [Evidence IDA] [PMID 20576760]; GO_function: GO:0005458 - GDP-mannose transmembrane transporter activity [Evidence IMP] [PMID 9395539]; GO_function: GO:0005338 - nucleotide-sugar transmembrane transporter activity [Evidence IEA]; GO_process: GO:0015784 - GDP-mannose transport [Evidence IMP] [PMID 9395539]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:1901679 - nucleotide transmembrane transport [Evidence IEA]; GO_process: GO:0015780 - nucleotide-sugar transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5128	Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability; GO_component: GO:0032302 - MutSbeta complex [Evidence IPI] [PMID 8805366]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000228 - nuclear chromosome [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0032135 - DNA insertion or deletion binding [Evidence IDA] [PMID 8805366]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IBA]; GO_function: GO:0000403 - Y-form DNA binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0003684 - damaged DNA binding [Evidence IBA]; GO_function: GO:0000406 - double-strand/single-strand DNA junction binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0000404 - heteroduplex DNA loop binding [Evidence IDA] [PMID 16781730]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IEA]; GO_function: GO:0030983 - mismatched DNA binding [Evidence IDA] [PMID 17636021]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 15920474]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IBA]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 16702432]; GO_process: GO:0006298 - mismatch repair [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 8510668]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 9520271]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 8849883]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IBA]; GO_process: GO:0000735 - removal of nonhomologous ends [Evidence IGI,IMP] [PMID 9256462]
AWJ20_5129	Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0047046 - homoisocitrate dehydrogenase activity [Evidence IEA]; GO_function: GO:0047046 - homoisocitrate dehydrogenase activity [Evidence IDA] [PMID 17223711]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IC] [PMID 17223711]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_5130	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; GO_component: GO:0033768 - SUMO-targeted ubiquitin ligase complex [Evidence IDA] [PMID 17848550]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19270524]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 17728242]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 17848550]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 18032921]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI,IMP] [PMID 11139495]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI,IMP] [PMID 16325482]; GO_process: GO:0016925 - protein sumoylation [Evidence IGI,IMP] [PMID 16387868]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 17728242]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 17848550]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA] [PMID 18032921]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 16428246]
AWJ20_5131	rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A, a human gene which is deleted in Williams-Beuren Syndrome; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 23913415]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10649453]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0009383 - rRNA (cytosine-C5-)-methyltransferase activity [Evidence IDA,IGI,IMP] [PMID 23913415]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0070475 - rRNA base methylation [Evidence IDA,IGI,IMP] [PMID 23913415]
AWJ20_5132	Essential protein involved in mtDNA inheritance; may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 12702300]; GO_process: GO:0006276 - plasmid maintenance [Evidence IMP] [PMID 12702300]
AWJ20_5133	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000177 - cytoplasmic exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0000178 - exosome (RNase complex) [Evidence IEA]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 10465791]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10465791]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0043628 - ncRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IMP] [PMID 19369424]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 10465791]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IC] [PMID 10465791]; GO_process: GO:0034427 - nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Evidence IC] [PMID 10465791]; GO_process: GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay [Evidence IC] [PMID 10465791]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IC] [PMID 10465791]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
AWJ20_5134	Mitochondrial and cytoplasmic valyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 3275649]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 3275649]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004832 - valine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004832 - valine-tRNA ligase activity [Evidence ISS] [PMID 3294828]; GO_function: GO:0004832 - valine-tRNA ligase activity [Evidence IDA] [PMID 782885]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006438 - valyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006438 - valyl-tRNA aminoacylation [Evidence IDA] [PMID 782885]
AWJ20_5135	Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10982841]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence IDA] [PMID 10982841]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IDA,TAS] [PMID 10982841]
AWJ20_5136	Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10982841]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003724 - RNA helicase activity [Evidence IDA] [PMID 10982841]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16449634]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IDA,TAS] [PMID 10982841]
AWJ20_5137	Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p; GO_component: GO:0000439 - core TFIIH complex [Evidence IEA]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 14500720]; GO_component: GO:0000439 - core TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0000112 - nucleotide-excision repair factor 3 complex [Evidence IDA] [PMID 8855246]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IMP] [PMID 7891722]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_5138	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12052880]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 17542652]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IDA] [PMID 12052880]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5139	Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; GO_component: GO:0016023 - cytoplasmic membrane-bounded vesicle [Evidence IDA] [PMID 11027260]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IDA] [PMID 10574989]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006877 - cellular cobalt ion homeostasis [Evidence IGI] [PMID 9115231]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IMP] [PMID 11602606]; GO_process: GO:0006824 - cobalt ion transport [Evidence IGI] [PMID 9115231]; GO_process: GO:0006828 - manganese ion transport [Evidence IMP] [PMID 11602606]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_5140	eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3); involved in the assembly of preinitiation complex and start codon selection; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 1332047]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IEA]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IDA,IPI] [PMID 15145951]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]; GO_process: GO:0006413 - translational initiation [Evidence IGI,IMP] [PMID 9722586]
AWJ20_5141	Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12973301]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15778719]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22908043]; GO_component: GO:0000502 - proteasome complex [Evidence IDA] [PMID 15778719]; GO_component: GO:0005839 - proteasome core complex [Evidence IDA,IMP] [PMID 15778719]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 23982732]; GO_function: GO:0016504 - peptidase activator activity [Evidence IDA] [PMID 22025621]; GO_function: GO:0070628 - proteasome binding [Evidence IDA,IMP] [PMID 22025621]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 12973301]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI] [PMID 17911101]; GO_process: GO:1990236 - proteasome core complex import into nucleus [Evidence IMP] [PMID 23982732]; GO_process: GO:0061136 - regulation of proteasomal protein catabolic process [Evidence IDA] [PMID 22025621]; GO_process: GO:1990237 - sequestration of proteasome core complex in proteasome storage granule [Evidence IMP] [PMID 23982732]
AWJ20_5147	Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 12408816]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0031929 - TOR signaling [Evidence IC] [PMID 12408816]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IPI] [PMID 12408816]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 12408816]; GO_process: GO:0001558 - regulation of cell growth [Evidence IPI] [PMID 12408816]
AWJ20_5148	Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004359 - glutaminase activity [Evidence IDA] [PMID 14764090]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0042823 - pyridoxal phosphate biosynthetic process [Evidence IEA]; GO_process: GO:0008615 - pyridoxine biosynthetic process [Evidence IEA]; GO_process: GO:0008615 - pyridoxine biosynthetic process [Evidence IMP] [PMID 12271461]; GO_process: GO:0008615 - pyridoxine biosynthetic process [Evidence IMP] [PMID 14764090]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IMP] [PMID 12271461]
AWJ20_5152	Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_5153	Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 16611745]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16611745]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IDA] [PMID 12407105]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 12407105]; GO_process: GO:0005979 - regulation of glycogen biosynthetic process [Evidence IGI] [PMID 11602261]; GO_process: GO:0005981 - regulation of glycogen catabolic process [Evidence IGI] [PMID 11602261]; GO_process: GO:0031647 - regulation of protein stability [Evidence IMP] [PMID 16611745]
AWJ20_5155	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16717099]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0015230 - FAD transmembrane transporter activity [Evidence IMP] [PMID 16717099]; GO_process: GO:0015883 - FAD transport [Evidence IMP] [PMID 16717099]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IMP] [PMID 16717099]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 16717099]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5157	Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IEA,IEA]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IMP] [PMID 10509018]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IDA] [PMID 10766767]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IDA] [PMID 11948191]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IDA] [PMID 19264153]; GO_function: GO:0004122 - cystathionine beta-synthase activity [Evidence IMP] [PMID 8366024]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0019344 - cysteine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006535 - cysteine biosynthetic process from serine [Evidence IEA]; GO_process: GO:0006535 - cysteine biosynthetic process from serine [Evidence IDA] [PMID 11948191]; GO_process: GO:0019343 - cysteine biosynthetic process via cystathionine [Evidence IEA]; GO_process: GO:0019343 - cysteine biosynthetic process via cystathionine [Evidence IMP] [PMID 10509018]; GO_process: GO:0019343 - cysteine biosynthetic process via cystathionine [Evidence IMP] [PMID 8366024]; GO_process: GO:0070814 - hydrogen sulfide biosynthetic process [Evidence IDA] [PMID 19531479]; GO_process: GO:0019346 - transsulfuration [Evidence IMP] [PMID 8366024]; GO_process: GO:0007089 - traversing start control point of mitotic cell cycle [Evidence IMP] [PMID 22438835]
AWJ20_5160	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog; GO_component: GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex [Evidence IEA]; GO_component: GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex [Evidence IDA] [PMID 19417106]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19417106]; GO_component: GO:0005739 - mitochondrion [Evidence IGI] [PMID 9287027]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA,IEA]; GO_function: GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 19417106]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0070681 - glutaminyl-tRNAGln biosynthesis via transamidation [Evidence IEA]; GO_process: GO:0070681 - glutaminyl-tRNAGln biosynthesis via transamidation [Evidence IDA] [PMID 19417106]; GO_process: GO:0032543 - mitochondrial translation [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 8082172]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_5161	Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003999 - adenine phosphoribosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003999 - adenine phosphoribosyltransferase activity [Evidence IDA] [PMID 9864350]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006167 - AMP biosynthetic process [Evidence TAS] [PMID 9357956]; GO_process: GO:0044209 - AMP salvage [Evidence IEA]; GO_process: GO:0006168 - adenine salvage [Evidence IEA]; GO_process: GO:0006168 - adenine salvage [Evidence IMP] [PMID 9864350]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0006166 - purine ribonucleoside salvage [Evidence IEA]
AWJ20_5162	Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 11839796]; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008353 - RNA polymerase II carboxy-terminal domain kinase activity [Evidence IEA]; GO_function: GO:0008353 - RNA polymerase II carboxy-terminal domain kinase activity [Evidence IDA] [PMID 7760796]; GO_function: GO:0008353 - RNA polymerase II carboxy-terminal domain kinase activity [Evidence IDA,IMP] [PMID 9702190]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0019912 - cyclin-dependent protein kinase activating kinase activity [Evidence IDA,IMP] [PMID 7760796]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0006370 - 7-methylguanosine mRNA capping [Evidence IMP] [PMID 22689984]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 11839796]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 7760796]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA,IMP] [PMID 9702190]; GO_process: GO:1901921 - phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [Evidence IMP,IPI] [PMID 10594013]; GO_process: GO:1900018 - phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 10594013]; GO_process: GO:1900018 - phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 19666497]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 14749387]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IMP] [PMID 12015980]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7760796]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7783209]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5163	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence IMP] [PMID 7622558]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 10358084]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 16297388]; GO_component: GO:0008250 - oligosaccharyltransferase complex [Evidence IPI] [PMID 9405463]; GO_function: GO:0004579 - dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Evidence IMP] [PMID 7622558]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IPI] [PMID 9405463]; GO_process: GO:0035269 - protein O-linked mannosylation [Evidence IGI] [PMID 22492205]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 10358084]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 7622558]
AWJ20_5164	SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants; GO_component: GO:0044697 - HICS complex [Evidence IPI] [PMID 22623719]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 21498574]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 21498574]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI] [PMID 22956544]; GO_process: GO:0000917 - barrier septum assembly [Evidence IGI,IPI] [PMID 19528296]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]
AWJ20_5168	Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7935837]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14517234]; GO_component: GO:0001405 - presequence translocase-associated import motor [Evidence IDA] [PMID 14638855]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 11096111]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 10464305]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_process: GO:0032079 - positive regulation of endodeoxyribonuclease activity [Evidence IDA] [PMID 10464305]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 10779357]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IDA] [PMID 8654364]; GO_process: GO:0042026 - protein refolding [Evidence IMP] [PMID 16460754]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9973563]; GO_process: GO:0043335 - protein unfolding [Evidence IMP] [PMID 8408192]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_5169	NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004352 - glutamate dehydrogenase (NAD+) activity [Evidence IEA,IEA]; GO_function: GO:0004352 - glutamate dehydrogenase (NAD+) activity [Evidence IMP,ISS] [PMID 1975578]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0019551 - glutamate catabolic process to 2-oxoglutarate [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IMP] [PMID 1975578]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_5170	Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17553781]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IGI] [PMID 17553781]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IDA] [PMID 17681937]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0015677 - copper ion import [Evidence IGI] [PMID 17553781]; GO_process: GO:0006825 - copper ion transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0006826 - iron ion transport [Evidence IGI] [PMID 17553781]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_5171	Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14729571]; GO_component: GO:0005840 - ribosome [Evidence TAS] [PMID 12067653]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence TAS] [PMID 12067653]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence TAS] [PMID 12067653]
AWJ20_5177	GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005093 - Rab GDP-dissociation inhibitor activity [Evidence IEA]; GO_function: GO:0005093 - Rab GDP-dissociation inhibitor activity [Evidence IDA] [PMID 8157010]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0050790 - regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IMP] [PMID 8157010]
AWJ20_5179	Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body duplication; homologous to human NUP210; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005641 - nuclear envelope lumen [Evidence IDA] [PMID 9988776]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 7559775]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 8138573]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 9988776]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA] [PMID 10684247]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA,IPI] [PMID 19414609]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA] [PMID 7559775]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0043495 - protein anchor [Evidence IDA] [PMID 7559775]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IC] [PMID 10684247]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006999 - nuclear pore organization [Evidence IGI] [PMID 19414609]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 8138573]; GO_process: GO:0006606 - protein import into nucleus [Evidence IDA] [PMID 7559775]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IGI] [PMID 20713690]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5180	Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body duplication; homologous to human NUP210; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005641 - nuclear envelope lumen [Evidence IDA] [PMID 9988776]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 7559775]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 8138573]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 9988776]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA] [PMID 10684247]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA,IPI] [PMID 19414609]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA] [PMID 7559775]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0043495 - protein anchor [Evidence IDA] [PMID 7559775]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IC] [PMID 10684247]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006999 - nuclear pore organization [Evidence IGI] [PMID 19414609]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 8138573]; GO_process: GO:0006606 - protein import into nucleus [Evidence IDA] [PMID 7559775]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IGI] [PMID 20713690]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5181	Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24335083]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISM] [PMID 19351663]; GO_function: GO:0070042 - rRNA (uridine-N3-)-methyltransferase activity [Evidence IMP] [PMID 24335083]; GO_process: GO:0070475 - rRNA base methylation [Evidence IMP] [PMID 24335083]
AWJ20_5183	Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 8830695]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI] [PMID 8830695]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]
AWJ20_5184	Intermediate filament protein; required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence TAS] [PMID 9245780]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005882 - intermediate filament [Evidence TAS] [PMID 9891785]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence TAS] [PMID 9891785]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence IDA] [PMID 9245780]; GO_process: GO:0007005 - mitochondrion organization [Evidence TAS] [PMID 9891785]; GO_process: GO:0007097 - nuclear migration [Evidence TAS] [PMID 9891785]; GO_process: GO:0038032 - termination of G-protein coupled receptor signaling pathway [Evidence IEA]
AWJ20_5186	Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11545731]; GO_component: GO:0005856 - cytoskeleton [Evidence IDA] [PMID 15910746]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11545731]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0032165 - prospore septin filament array [Evidence IDA] [PMID 24390141]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 10893184]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IEA]; GO_function: GO:0004697 - protein kinase C activity [Evidence IDA] [PMID 8207005]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0007015 - actin filament organization [Evidence IGI] [PMID 12810699]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IMP] [PMID 21163942]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IMP] [PMID 7874200]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8207005]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 7874200]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IMP] [PMID 21163942]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 7874200]
AWJ20_5187	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0044611 - nuclear pore inner ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IGI] [PMID 16361228]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IGI] [PMID 8682855]; GO_process: GO:0031990 - mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 18258809]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006999 - nuclear pore organization [Evidence IGI,IMP] [PMID 8682855]; GO_process: GO:0006606 - protein import into nucleus [Evidence IGI] [PMID 16361228]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5190	Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence TAS] [PMID 11717306]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain [Evidence TAS] [PMID 9442887]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 10224039]; GO_function: GO:0046961 - proton-transporting ATPase activity, rotational mechanism [Evidence TAS] [PMID 9442887]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]
AWJ20_5191	Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004039 - allophanate hydrolase activity [Evidence IEA]; GO_function: GO:0004039 - allophanate hydrolase activity [Evidence IMP] [PMID 6105114]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IEA]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA]; GO_function: GO:0004847 - urea carboxylase activity [Evidence IEA]; GO_function: GO:0004847 - urea carboxylase activity [Evidence IMP] [PMID 6105114]; GO_process: GO:0000256 - allantoin catabolic process [Evidence TAS] [PMID 1938916]; GO_process: GO:0006525 - arginine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IEA]; GO_process: GO:0043419 - urea catabolic process [Evidence IMP] [PMID 6105114]
AWJ20_5192	Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex are: Cab3p, Sis2p, Vhs3p, while the subunits of the CoA-synthesizing protein complex (CoA-SPC) are: Cab2p, Cab3p, Cab4p, and Cab5p as well as Sis2p and Vhs3p; null mutant lethality is complemented by E. coli coaBC; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0071513 - phosphopantothenoylcysteine decarboxylase complex [Evidence IDA] [PMID 19915539]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence ISS] [PMID 14690591]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence IDA,IMP] [PMID 19915539]; GO_function: GO:0017076 - purine nucleotide binding [Evidence ISS] [PMID 7705654]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 10592175]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 14690591]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]; GO_process: GO:0009651 - response to salt stress [Evidence IGI] [PMID 8923737]
AWJ20_5194	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19182805]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_5196	C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0000249 - C-22 sterol desaturase activity [Evidence IDA] [PMID 8543054]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8543054]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 8635732]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
AWJ20_5198	High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5199	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
AWJ20_5200	Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 17430883]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 17430883]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 17430883]; GO_process: GO:0016558 - protein import into peroxisome matrix [Evidence IMP] [PMID 19118449]
AWJ20_5202	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; GO_component: GO:0005619 - ascospore wall [Evidence IDA] [PMID 8636217]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 1934633]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 18826657]; GO_component: GO:0001400 - mating projection base [Evidence IDA] [PMID 8791410]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0072687 - meiotic spindle [Evidence IDA] [PMID 18826657]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 18826657]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 18826657]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IC] [PMID 10882120]; GO_process: GO:0000281 - mitotic cytokinesis [Evidence IMP] [PMID 4950437]; GO_process: GO:0045860 - positive regulation of protein kinase activity [Evidence IDA] [PMID 14527412]
AWJ20_5204	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence ISS] [PMID 8972580]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006624 - vacuolar protein processing [Evidence IMP] [PMID 21912603]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 21912603]
AWJ20_5205	Exo-1,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 7875558]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence IEA]; GO_function: GO:0004338 - glucan exo-1,3-beta-glucosidase activity [Evidence IDA] [PMID 7875558]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IC] [PMID 7875558]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_5207	Myosin-like protein associated with the nuclear envelope; connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 10085285]; GO_component: GO:0005643 - nuclear pore [Evidence IEA]; GO_component: GO:0044615 - nuclear pore nuclear basket [Evidence IDA] [PMID 24152732]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 10085285]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IPI] [PMID 15692572]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 16027220]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IGI,IPI] [PMID 15692572]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:1901925 - negative regulation of protein import into nucleus during spindle assembly checkpoint [Evidence IGI] [PMID 23177738]; GO_process: GO:0071048 - nuclear retention of unspliced pre-mRNA at the site of transcription [Evidence IGI,IMP] [PMID 14718167]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence IMP] [PMID 21036941]; GO_process: GO:0006606 - protein import into nucleus [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IGI] [PMID 10085285]; GO_process: GO:0090204 - protein localization to nuclear pore [Evidence IMP] [PMID 19933151]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IGI] [PMID 10638763]; GO_process: GO:0090203 - transcriptional activation by promoter-terminator looping [Evidence IMP] [PMID 19933151]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5208	Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10069808]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 12023081]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 10514566]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 16704983]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 17311586]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0015867 - ATP transport [Evidence IDA] [PMID 12807869]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IDA] [PMID 12023081]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 16704983]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 17311586]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_5210	weak similarity to sphingosine kinase/eukaryotic diacylglycerol kinase involved in Protein Kinase C activation; similar to C terminus of predicted N. crassa protein (NCU06337.1); allele of CaO19.12149
AWJ20_5212	Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 3549696]
AWJ20_5214	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IMP,ISS] [PMID 10788431]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 19496824]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IMP] [PMID 10652283]; GO_function: GO:0005427 - proton-dependent oligopeptide secondary active transmembrane transporter activity [Evidence IDA] [PMID 16149917]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA] [PMID 16149917]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006790 - sulfur compound metabolic process [Evidence IEP] [PMID 11862495]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5215	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004033 - aldo-keto reductase (NADP) activity [Evidence IDA] [PMID 17140678]; GO_function: GO:0051268 - alpha-keto amide reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0051269 - alpha-keto ester reductase activity [Evidence IDA] [PMID 15564669]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0043603 - cellular amide metabolic process [Evidence IDA] [PMID 15564669]; GO_process: GO:0006725 - cellular aromatic compound metabolic process [Evidence IDA] [PMID 16268655]; GO_process: GO:0042180 - cellular ketone metabolic process [Evidence IDA] [PMID 17140678]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_5216	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_function: GO:0045462 - trichothecene 3-O-acetyltransferase activity [Evidence IMP] [PMID 12478589]; GO_process: GO:0043387 - mycotoxin catabolic process [Evidence IMP] [PMID 12478589]
AWJ20_5218	Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006449 - regulation of translational termination [Evidence IMP] [PMID 11570975]
AWJ20_5219	U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex; GO_component: GO:0005685 - U1 snRNP [Evidence IDA] [PMID 9630245]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IMP] [PMID 15020406]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 8622699]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IDA] [PMID 8622699]
AWJ20_5220	Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; GO_component: GO:0000502 - proteasome complex [Evidence IPI] [PMID 12408819]; GO_component: GO:0005838 - proteasome regulatory particle [Evidence IPI] [PMID 11029046]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 12408819]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 17018280]; GO_process: GO:1901799 - negative regulation of proteasomal protein catabolic process [Evidence IMP] [PMID 17018280]; GO_process: GO:0016579 - protein deubiquitination [Evidence IMP] [PMID 12408819]; GO_process: GO:0016579 - protein deubiquitination [Evidence IGI] [PMID 14581483]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
AWJ20_5221	Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic19p is peripheral to the inner membrane; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21944719]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21987634]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 22009199]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0044284 - mitochondrial crista junction [Evidence IDA] [PMID 22009199]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21944719]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21987634]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 22009199]
AWJ20_5223	Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 3550419]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 3550419]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 3546317]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006113 - fermentation [Evidence ISS] [PMID 3550419]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_5224	XP_962611|transcriptional activator xlnR [Neurospora crassa OR74A]
AWJ20_5225	Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
AWJ20_5227	Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 22593576]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 3888995]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005657 - replication fork [Evidence IDA] [PMID 15773893]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 1704371]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 3888995]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 3907855]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0001882 - nucleoside binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 2651896]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IBA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IC] [PMID 3888995]; GO_process: GO:0006269 - DNA replication, synthesis of RNA primer [Evidence IBA]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IBA]; GO_process: GO:0000731 - DNA synthesis involved in DNA repair [Evidence IMP] [PMID 2651896]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IDA] [PMID 17429354]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 10025407]; GO_process: GO:0000734 - gene conversion at mating-type locus, DNA repair synthesis [Evidence IBA]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 3888995]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0006279 - premeiotic DNA replication [Evidence IMP] [PMID 2651896]
AWJ20_5233	High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5235	Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 8413229]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 11734006]; GO_function: GO:0051787 - misfolded protein binding [Evidence IDA] [PMID 7628444]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 7628444]; GO_process: GO:0034605 - cellular response to heat [Evidence IGI,IMP] [PMID 8830768]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 7500331]; GO_process: GO:0042026 - protein refolding [Evidence IDA,IMP] [PMID 11734006]; GO_process: GO:0050821 - protein stabilization [Evidence IMP] [PMID 16460754]; GO_process: GO:0050821 - protein stabilization [Evidence IGI] [PMID 7628444]; GO_process: GO:0043335 - protein unfolding [Evidence IMP] [PMID 16460754]; GO_process: GO:0006950 - response to stress [Evidence IEA]
AWJ20_5236	pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23019326]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 10821185]; GO_process: GO:0071469 - cellular response to alkalinity [Evidence IMP] [PMID 23019326]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IGI,IMP] [PMID 16524906]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10821185]
AWJ20_5237	Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 9756928]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9756928]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9756928]
AWJ20_5238	Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 9813046]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 9837886]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004165 - dodecenoyl-CoA delta-isomerase activity [Evidence IEA]; GO_function: GO:0004165 - dodecenoyl-CoA delta-isomerase activity [Evidence IDA,IMP] [PMID 9813046]; GO_function: GO:0004165 - dodecenoyl-CoA delta-isomerase activity [Evidence IDA,IMP] [PMID 9837886]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IEA]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IDA] [PMID 9813046]; GO_process: GO:0006635 - fatty acid beta-oxidation [Evidence IDA] [PMID 9837886]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_5240	O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 10419476]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10419476]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10760477]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008425 - 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Evidence IEA]; GO_function: GO:0061543 - 3-demethylubiquinone-6 3-O-methyltransferase activity [Evidence IMP] [PMID 10419476]; GO_function: GO:0008689 - 3-demethylubiquinone-9 3-O-methyltransferase activity [Evidence IEA]; GO_function: GO:0004395 - hexaprenyldihydroxybenzoate methyltransferase activity [Evidence IEA]; GO_function: GO:0004395 - hexaprenyldihydroxybenzoate methyltransferase activity [Evidence IMP] [PMID 1885593]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IDA] [PMID 10419476]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 1885593]
AWJ20_5241	Protein involved in late endosome to vacuole transport; cytoplasmic and vacuolar membrane protein; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23708375]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 12940986]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 18032584]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5243	Alanine:glyoxylate aminotransferase (AGT); catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008453 - alanine-glyoxylate transaminase activity [Evidence IEA]; GO_function: GO:0008453 - alanine-glyoxylate transaminase activity [Evidence IMP] [PMID 14745783]; GO_function: GO:0008453 - alanine-glyoxylate transaminase activity [Evidence IDA] [PMID 16226833]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006545 - glycine biosynthetic process [Evidence IEA]; GO_process: GO:0019265 - glycine biosynthetic process, by transamination of glyoxylate [Evidence IDA] [PMID 16226833]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
AWJ20_5247	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005795 - Golgi stack [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 20016005]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004609 - phosphatidylserine decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004609 - phosphatidylserine decarboxylase activity [Evidence IGI] [PMID 14660568]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006656 - phosphatidylcholine biosynthetic process [Evidence IDA] [PMID 6427211]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
AWJ20_5248	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 8599931]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 1327750]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008320 - protein transmembrane transporter activity [Evidence IMP] [PMID 22017868]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IMP,IPI] [PMID 10508156]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 22017868]; GO_process: GO:0032979 - protein insertion into mitochondrial membrane from inner side [Evidence IMP,IPI] [PMID 22017868]
AWJ20_5249	Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 1429680]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 1429680]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 24069405]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA] [PMID 15933713]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA,IMP] [PMID 24069405]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IGI,IMP,IPI] [PMID 19165343]
AWJ20_5250	Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 1429680]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 1429680]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA,IMP] [PMID 24069405]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA] [PMID 15933713]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA,IMP] [PMID 24069405]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]; GO_process: GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Evidence IGI,IMP,IPI] [PMID 19165343]
AWJ20_5251	Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 18410729]; GO_component: GO:0032580 - Golgi cisterna membrane [Evidence IEA]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 22553352]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18410729]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 18635803]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019899 - enzyme binding [Evidence IPI] [PMID 18410729]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0070273 - phosphatidylinositol-4-phosphate binding [Evidence IDA,IMP] [PMID 20026658]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 16582425]; GO_process: GO:0034067 - protein localization to Golgi apparatus [Evidence IMP] [PMID 18410729]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0060304 - regulation of phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 22553352]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 18635803]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5253	Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome; GO_component: GO:0000790 - nuclear chromatin [Evidence IMP] [PMID 24086532]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10931920]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15020404]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003678 - DNA helicase activity [Evidence IMP,ISS] [PMID 10931920]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0034085 - establishment of sister chromatid cohesion [Evidence IMP] [PMID 23334284]; GO_process: GO:0036297 - interstrand cross-link repair [Evidence IGI] [PMID 22912599]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP,IPI] [PMID 15020404]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 17483413]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]
AWJ20_5255	Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 3546317]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006116 - NADH oxidation [Evidence IDA] [PMID 3546317]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006067 - ethanol metabolic process [Evidence IDA] [PMID 3546317]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_5256	Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 17634286]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0043248 - proteasome assembly [Evidence IGI,ISS] [PMID 17431397]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP] [PMID 17634286]
AWJ20_5259	Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 15082539]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 21844196]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 21844196]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 21532343]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IDA] [PMID 21844196]
AWJ20_5261	Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, and chromatin dynamics during transcription; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0033186 - CAF-1 complex [Evidence IDA] [PMID 9030687]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IDA] [PMID 11782447]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 16503640]; GO_process: GO:0006335 - DNA replication-dependent nucleosome assembly [Evidence IDA,IMP] [PMID 9030687]
AWJ20_5267	Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IGI,IPI] [PMID 23318452]; GO_process: GO:0006413 - translational initiation [Evidence IGI,IPI] [PMID 23318452]
AWJ20_5268	Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication; GO_component: GO:0000837 - Doa10p ubiquitin ligase complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex [Evidence IDA] [PMID 16873066]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 9388185]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 23665229]; GO_function: GO:0097027 - ubiquitin-protein transferase activator activity [Evidence IDA] [PMID 18321851]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 9388185]; GO_process: GO:0097051 - establishment of protein localization to endoplasmic reticulum membrane [Evidence IMP] [PMID 9388185]
AWJ20_5271	Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 6094555]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 6094555]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004798 - thymidylate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004798 - thymidylate kinase activity [Evidence IDA] [PMID 6088527]; GO_function: GO:0004798 - thymidylate kinase activity [Evidence IDA] [PMID 6094555]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0009041 - uridylate kinase activity [Evidence IDA] [PMID 6094555]; GO_process: GO:0006233 - dTDP biosynthetic process [Evidence IEA]; GO_process: GO:0006233 - dTDP biosynthetic process [Evidence IDA] [PMID 6094555]; GO_process: GO:0006235 - dTTP biosynthetic process [Evidence IEA]; GO_process: GO:0006235 - dTTP biosynthetic process [Evidence IDA] [PMID 6094555]; GO_process: GO:0006227 - dUDP biosynthetic process [Evidence IDA] [PMID 6094555]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
AWJ20_5274	Monoglyceride lipase (MGL); functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 20554061]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 20554061]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0047372 - acylglycerol lipase activity [Evidence IEA]; GO_function: GO:0047372 - acylglycerol lipase activity [Evidence IMP] [PMID 20554061]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017171 - serine hydrolase activity [Evidence IDA,ISM] [PMID 14645503]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IEA]; GO_process: GO:0006641 - triglyceride metabolic process [Evidence IMP] [PMID 20554061]
AWJ20_5277	Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IPI] [PMID 10358023]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0048312 - intracellular distribution of mitochondria [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 9601101]; GO_process: GO:0006413 - translational initiation [Evidence IPI] [PMID 10358023]
AWJ20_5278	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
AWJ20_5279	GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication; GO_component: GO:0005798 - Golgi-associated vesicle [Evidence IDA] [PMID 15331637]; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15331637]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 15331637]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12189143]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 15331637]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15331637]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IGI,IPI,ISS] [PMID 12189143]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IGI,IPI] [PMID 15802519]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 15802519]; GO_process: GO:0006887 - exocytosis [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI] [PMID 12189143]
AWJ20_5280	Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9191025]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 10942767]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 9191025]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 10942767]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA,IPI] [PMID 9927435]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 10942767]
AWJ20_5283	Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
AWJ20_5284	RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0016591 - DNA-directed RNA polymerase II, holoenzyme [Evidence IPI] [PMID 16554755]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19679657]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21504834]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19679657]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21504834]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 21504834]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 21504834]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:1990022 - RNA polymerase III complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IMP] [PMID 21504834]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5285	Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 10393809]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 16239147]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 24390141]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 10393809]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_function: GO:0003779 - actin binding [Evidence IEA]; GO_function: GO:0008092 - cytoskeletal protein binding [Evidence IPI,ISS] [PMID 10388809]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20610658]; GO_process: GO:0051666 - actin cortical patch localization [Evidence IMP] [PMID 8590801]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20610658]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IGI,IPI] [PMID 15802519]
AWJ20_5288	Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 11784867]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9219339]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IGI,IMP] [PMID 11784867]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 11784867]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
AWJ20_5290	Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 18675371]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11533229]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 18675371]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 11533229]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 16055745]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11533229]; GO_process: GO:0035961 - positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 16055745]; GO_process: GO:0035969 - positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 11208779]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5293	Cyclin associated with protein kinase Kin28p; Kin28p is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters; GO_component: GO:0070985 - TFIIK complex [Evidence IEA]; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 11839796]; GO_component: GO:0070985 - TFIIK complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005675 - holo TFIIH complex [Evidence IDA] [PMID 19818408]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0000990 - core RNA polymerase binding transcription factor activity [Evidence IC] [PMID 19818408]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IEA]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IGI,IPI] [PMID 8230216]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 11839796]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19450536]; GO_process: GO:0070816 - phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 19679665]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 19818408]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
AWJ20_5295	hypothetical protein; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
AWJ20_5296	Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 17956976]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14690591]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17956976]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 17956976]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 17956976]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17956976]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17956976]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17956976]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IMP] [PMID 17956976]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_5300	Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog; GO_component: GO:0032133 - chromosome passenger complex [Evidence IDA] [PMID 19158380]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IGI,IPI] [PMID 10557299]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16608876]; GO_component: GO:0005874 - microtubule [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16608876]; GO_component: GO:0005819 - spindle [Evidence IDA] [PMID 16381814]; GO_component: GO:0051233 - spindle midzone [Evidence IDA] [PMID 16381814]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 16608876]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 10557299]; GO_process: GO:0000022 - mitotic spindle elongation [Evidence IMP] [PMID 16381814]; GO_process: GO:0031134 - sister chromatid biorientation [Evidence IMP] [PMID 19528231]; GO_process: GO:0071173 - spindle assembly checkpoint [Evidence IMP] [PMID 22908045]
AWJ20_5301	PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003729 - mRNA binding [Evidence ISS] [PMID 11101532]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15024427]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21685478]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IGI] [PMID 11101532]
AWJ20_5302	Mitochondrial elongation factor involved in translational elongation; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 1935960]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence IEA,IEA]; GO_function: GO:0003746 - translation elongation factor activity [Evidence ISA] [PMID 1935960]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 1935960]; GO_process: GO:0070125 - mitochondrial translational elongation [Evidence ISA] [PMID 1935960]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006414 - translational elongation [Evidence IEA,IEA,IEA]
AWJ20_5303	Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; GO_component: GO:0030122 - AP-2 adaptor complex [Evidence IMP] [PMID 10564262]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 19458192]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IC] [PMID 10564262]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
AWJ20_5305	Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 11030653]; GO_component: GO:0033101 - cellular bud membrane [Evidence IDA] [PMID 13679573]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 23237950]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11030653]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17234190]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23237950]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 19453974]; GO_process: GO:0090158 - endoplasmic reticulum membrane organization [Evidence IGI] [PMID 23237950]; GO_process: GO:0072659 - protein localization to plasma membrane [Evidence IMP] [PMID 24416406]; GO_process: GO:0060304 - regulation of phosphatidylinositol dephosphorylation [Evidence IGI] [PMID 23237950]
AWJ20_5306	B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 22593576]; GO_component: GO:0005658 - alpha DNA polymerase:primase complex [Evidence IDA] [PMID 3888995]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15282802]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8289832]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 1704371]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IDA] [PMID 3888995]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 8289832]; GO_process: GO:0006273 - lagging strand elongation [Evidence IC] [PMID 3888995]; GO_process: GO:0016233 - telomere capping [Evidence IGI,IMP,IPI] [PMID 15132993]
AWJ20_5307	Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_function: GO:0008418 - protein-N-terminal asparagine amidohydrolase activity [Evidence IDA] [PMID 23218487]; GO_function: GO:0008418 - protein-N-terminal asparagine amidohydrolase activity [Evidence IDA,IMP] [PMID 7744855]; GO_function: GO:0070773 - protein-N-terminal glutamine amidohydrolase activity [Evidence IDA] [PMID 23218487]; GO_function: GO:0070773 - protein-N-terminal glutamine amidohydrolase activity [Evidence IMP] [PMID 7744855]; GO_process: GO:0006464 - cellular protein modification process [Evidence IMP] [PMID 7744855]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IMP] [PMID 7744855]
AWJ20_5308	RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11720288]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 11720288]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10564276]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 7799435]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence IDA] [PMID 19749380]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IMP] [PMID 9150139]
AWJ20_5310	Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0071627 - integral component of fungal-type vacuolar membrane [Evidence IDA] [PMID 23169667]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015326 - cationic amino acid transmembrane transporter activity [Evidence IMP,ISO] [PMID 23169667]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0034488 - basic amino acid transmembrane export from vacuole [Evidence IMP,ISO] [PMID 23169667]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5312	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25B has a paralog, RPS25A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 6814480]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 6814480]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 6814480]
AWJ20_5314	WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16221974]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 16221974]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_5315	Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0019135 - deoxyhypusine monooxygenase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0019135 - deoxyhypusine monooxygenase activity [Evidence IDA,IMP] [PMID 16371467]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IGI,IMP] [PMID 14767070]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IEA,IEA,IEA]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IDA,IMP] [PMID 16371467]
AWJ20_5316	Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
AWJ20_5319	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0000144 - cellular bud neck septin ring [Evidence IDA] [PMID 3316985]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005937 - mating projection [Evidence IDA] [PMID 18552279]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_component: GO:0031105 - septin complex [Evidence IEA]; GO_component: GO:0031105 - septin complex [Evidence IDA] [PMID 18550837]; GO_component: GO:0031105 - septin complex [Evidence IPI] [PMID 9813094]; GO_component: GO:0032160 - septin filament array [Evidence IDA] [PMID 15282341]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence IDA] [PMID 12665577]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 14597621]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 14993234]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0032947 - protein complex scaffold [Evidence IMP] [PMID 9442111]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 18550837]; GO_process: GO:0007049 - cell cycle [Evidence IEA,IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IMP] [PMID 10882120]; GO_process: GO:0045860 - positive regulation of protein kinase activity [Evidence IDA] [PMID 14527412]; GO_process: GO:0000921 - septin ring assembly [Evidence IDA] [PMID 12636916]; GO_process: GO:0000921 - septin ring assembly [Evidence IMP] [PMID 14993234]
AWJ20_5320	RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IMP] [PMID 1400451]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5321	Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18406344]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0008198 - ferrous iron binding [Evidence IDA] [PMID 18406344]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004791 - thioredoxin-disulfide reductase activity [Evidence IEA,IEA]; GO_function: GO:0004791 - thioredoxin-disulfide reductase activity [Evidence IDA] [PMID 7961686]; GO_process: GO:0045454 - cell redox homeostasis [Evidence IDA,IMP] [PMID 9571241]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 15051715]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0019430 - removal of superoxide radicals [Evidence IEA]
AWJ20_5322	Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0005745 - m-AAA complex [Evidence IDA] [PMID 8681382]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0097002 - mitochondrial inner boundary membrane [Evidence IDA] [PMID 19019989]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7929327]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 19748354]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 19748354]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7929327]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IMP] [PMID 8681382]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 19748354]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 8681382]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence TAS] [PMID 12417197]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IMP] [PMID 8681382]; GO_process: GO:0006465 - signal peptide processing [Evidence IMP] [PMID 12417197]
AWJ20_5323	Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9288922]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA,IMP] [PMID 9288922]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IDA] [PMID 1859361]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IMP] [PMID 9288922]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 15780654]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 9288922]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]
AWJ20_5326	Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; required for proper actin organization; also localizes to plasma membrane and sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to the TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; GO_component: GO:0005933 - cellular bud [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22593206]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 10679030]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22593206]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22593206]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 10679030]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 22593206]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 22593206]; GO_component: GO:0000133 - polarisome [Evidence IDA] [PMID 16166638]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA] [PMID 10559187]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IDA,IMP] [PMID 22593206]; GO_process: GO:0032858 - activation of Rab GTPase activity [Evidence IDA] [PMID 22593206]; GO_process: GO:0006897 - endocytosis [Evidence IMP,IPI] [PMID 22593206]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 12913108]; GO_process: GO:0070649 - formin-nucleated actin cable assembly [Evidence IGI,IPI] [PMID 16166638]; GO_process: GO:0043087 - regulation of GTPase activity [Evidence IMP] [PMID 22593206]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP,IPI] [PMID 22593206]
AWJ20_5329	D-lactate dehydrogenase; located in the mitochondrial matrix; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10509019]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IDA] [PMID 10509019]; GO_function: GO:0008762 - UDP-N-acetylmuramate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003779 - actin binding [Evidence IMP,IPI] [PMID 15158445]; GO_function: GO:0003779 - actin binding [Evidence IPI] [PMID 7719850]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors [Evidence IEA]; GO_process: GO:0006089 - lactate metabolic process [Evidence TAS] [PMID 10509019]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
AWJ20_5330	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 9864355]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA] [PMID 10684247]; GO_component: GO:0070762 - nuclear pore transmembrane ring [Evidence IDA,IPI] [PMID 19414609]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9864355]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IC] [PMID 10684247]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006999 - nuclear pore organization [Evidence IGI,IMP] [PMID 15075274]; GO_process: GO:0006999 - nuclear pore organization [Evidence IGI,IMP] [PMID 16682526]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 9864355]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IMP] [PMID 15075274]; GO_process: GO:0030474 - spindle pole body duplication [Evidence IMP] [PMID 8349727]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5331	Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:1990071 - TRAPPII protein complex [Evidence IDA] [PMID 11239471]; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 16314430]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16314430]; GO_function: GO:0017112 - Rab guanyl-nucleotide exchange factor activity [Evidence IMP] [PMID 17041589]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 16314430]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IMP] [PMID 11239471]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IMP] [PMID 17041589]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5332	Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
AWJ20_5333	Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005662 - DNA replication factor A complex [Evidence IDA] [PMID 2554144]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IMP] [PMID 14702040]; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 9679065]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 7761422]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 7761422]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 8804316]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 9093844]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 9093844]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 22885009]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IDA] [PMID 2554144]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IGI] [PMID 9679065]; GO_process: GO:0045184 - establishment of protein localization [Evidence IMP] [PMID 14702040]; GO_process: GO:0030491 - heteroduplex formation [Evidence IDA] [PMID 12226081]; GO_process: GO:0006312 - mitotic recombination [Evidence IPI] [PMID 2554144]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IDA,IMP] [PMID 8910442]; GO_process: GO:0016567 - protein ubiquitination [Evidence IPI] [PMID 18342608]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IPI] [PMID 2554144]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IPI] [PMID 2554144]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 14702040]; GO_process: GO:0010833 - telomere maintenance via telomere lengthening [Evidence IMP] [PMID 22354040]
AWJ20_5335	C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10722850]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000246 - delta24(24-1) sterol reductase activity [Evidence IEA]; GO_function: GO:0000246 - delta24(24-1) sterol reductase activity [Evidence IDA] [PMID 14922]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016628 - oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 8125337]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA,IEA]
AWJ20_5336	Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0030532 - small nuclear ribonucleoprotein complex [Evidence TAS] [PMID 10690410]; GO_component: GO:0005732 - small nucleolar ribonucleoprotein complex [Evidence TAS] [PMID 10690410]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9814757]; GO_process: GO:0000154 - rRNA modification [Evidence TAS] [PMID 10690410]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_5337	Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16861225]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22735702]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16861225]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16861225]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP,IPI] [PMID 11583614]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
AWJ20_5338	Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8045256]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12374868]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 7679674]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 7679674]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 11389139]; GO_function: GO:0015440 - peptide-transporting ATPase activity [Evidence IDA,IMP] [PMID 8626301]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0000770 - peptide pheromone export [Evidence IMP] [PMID 2569166]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_5341	Forkhead transcription factor; drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20847055]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12464632]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19159085]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20847055]; GO_component: GO:0005667 - transcription factor complex [Evidence IBA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003705 - RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IBA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA,IMP] [PMID 9920414]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0008134 - transcription factor binding [Evidence IBA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 20847055]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 20847055]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 8441413]; GO_process: GO:0051090 - regulation of sequence-specific DNA binding transcription factor activity [Evidence IBA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0051300 - spindle pole body organization [Evidence IGI] [PMID 9920414]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
AWJ20_5344	Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
AWJ20_5346	Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]