-- dump date 20140620_085349 -- class Genbank::misc_feature -- table misc_feature_note -- id note 525381000001 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 525381000002 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 525381000003 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 525381000004 putative homodimer interface [polypeptide binding]; other site 525381000005 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 525381000006 heterodimer interface [polypeptide binding]; other site 525381000007 homodimer interface [polypeptide binding]; other site 525381000008 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 525381000009 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 525381000010 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 525381000011 Transglycosylase; Region: Transgly; pfam00912 525381000012 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 525381000013 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525381000014 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525381000015 active site 525381000016 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 525381000017 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 525381000018 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 525381000019 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 525381000020 FtsX-like permease family; Region: FtsX; pfam02687 525381000021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381000022 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381000023 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381000024 Winged helix-turn helix; Region: HTH_29; pfam13551 525381000025 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 525381000026 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 525381000027 dimerization interface [polypeptide binding]; other site 525381000028 active site 525381000029 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 525381000030 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525381000031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 525381000032 Walker A/P-loop; other site 525381000033 ATP binding site [chemical binding]; other site 525381000034 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 525381000035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525381000036 DNA-binding site [nucleotide binding]; DNA binding site 525381000037 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 525381000038 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 525381000039 beta-galactosidase; Region: BGL; TIGR03356 525381000040 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 525381000041 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 525381000042 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 525381000043 active site 525381000044 P-loop; other site 525381000045 phosphorylation site [posttranslational modification] 525381000046 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 525381000047 methionine cluster; other site 525381000048 active site 525381000049 phosphorylation site [posttranslational modification] 525381000050 metal binding site [ion binding]; metal-binding site 525381000051 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 525381000052 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 525381000053 putative catalytic cysteine [active] 525381000054 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 525381000055 putative active site [active] 525381000056 metal binding site [ion binding]; metal-binding site 525381000057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 525381000058 MORN repeat; Region: MORN; cl14787 525381000059 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 525381000060 Low molecular weight phosphatase family; Region: LMWPc; cd00115 525381000061 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 525381000062 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 525381000063 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 525381000064 TPP-binding site [chemical binding]; other site 525381000065 dimer interface [polypeptide binding]; other site 525381000066 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 525381000067 PYR/PP interface [polypeptide binding]; other site 525381000068 dimer interface [polypeptide binding]; other site 525381000069 TPP binding site [chemical binding]; other site 525381000070 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525381000071 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 525381000072 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 525381000073 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 525381000074 PRD domain; Region: PRD; pfam00874 525381000075 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 525381000076 active site 525381000077 P-loop; other site 525381000078 phosphorylation site [posttranslational modification] 525381000079 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 525381000080 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 525381000081 intersubunit interface [polypeptide binding]; other site 525381000082 active site 525381000083 Zn2+ binding site [ion binding]; other site 525381000084 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 525381000085 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 525381000086 AP (apurinic/apyrimidinic) site pocket; other site 525381000087 DNA interaction; other site 525381000088 Metal-binding active site; metal-binding site 525381000089 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 525381000090 active site 525381000091 dimer interface [polypeptide binding]; other site 525381000092 magnesium binding site [ion binding]; other site 525381000093 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 525381000094 active site 525381000095 phosphorylation site [posttranslational modification] 525381000096 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 525381000097 active site 525381000098 P-loop; other site 525381000099 phosphorylation site [posttranslational modification] 525381000100 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 525381000101 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 525381000102 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 525381000103 G-X-X-G motif; other site 525381000104 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 525381000105 RxxxH motif; other site 525381000106 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 525381000107 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 525381000108 ribonuclease P; Reviewed; Region: rnpA; PRK00499 525381000109 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 525381000110 propionate/acetate kinase; Provisional; Region: PRK12379 525381000111 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 525381000112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381000113 S-adenosylmethionine binding site [chemical binding]; other site 525381000114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381000115 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 525381000116 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 525381000117 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 525381000118 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 525381000119 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 525381000120 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 525381000121 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 525381000122 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525381000123 Walker A motif; other site 525381000124 ATP binding site [chemical binding]; other site 525381000125 Walker B motif; other site 525381000126 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 525381000127 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 525381000128 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 525381000129 catalytic Zn binding site [ion binding]; other site 525381000130 structural Zn binding site [ion binding]; other site 525381000131 NAD(P) binding site [chemical binding]; other site 525381000132 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 525381000133 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 525381000134 active site 525381000135 dimer interface [polypeptide binding]; other site 525381000136 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 525381000137 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 525381000138 catalytic triad [active] 525381000139 catalytic triad [active] 525381000140 oxyanion hole [active] 525381000141 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 525381000142 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 525381000143 Predicted integral membrane protein [Function unknown]; Region: COG5523 525381000144 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 525381000145 putative substrate binding pocket [chemical binding]; other site 525381000146 AC domain interface; other site 525381000147 catalytic triad [active] 525381000148 AB domain interface; other site 525381000149 interchain disulfide; other site 525381000150 Predicted membrane protein [Function unknown]; Region: COG3759 525381000151 Transcriptional regulators [Transcription]; Region: MarR; COG1846 525381000152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525381000153 putative DNA binding site [nucleotide binding]; other site 525381000154 putative Zn2+ binding site [ion binding]; other site 525381000155 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525381000156 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 525381000157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381000158 motif II; other site 525381000159 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525381000160 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 525381000161 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 525381000162 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 525381000163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381000164 catalytic residue [active] 525381000165 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 525381000166 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 525381000167 active site 525381000168 catalytic motif [active] 525381000169 Zn binding site [ion binding]; other site 525381000170 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 525381000171 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525381000172 active site 525381000173 HIGH motif; other site 525381000174 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525381000175 active site 525381000176 KMSKS motif; other site 525381000177 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 525381000178 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 525381000179 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 525381000180 active site 525381000181 dimer interface [polypeptide binding]; other site 525381000182 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 525381000183 dimer interface [polypeptide binding]; other site 525381000184 active site 525381000185 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 525381000186 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 525381000187 catalytic triad [active] 525381000188 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525381000189 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381000190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381000191 Walker A/P-loop; other site 525381000192 ATP binding site [chemical binding]; other site 525381000193 Q-loop/lid; other site 525381000194 ABC transporter signature motif; other site 525381000195 Walker B; other site 525381000196 D-loop; other site 525381000197 H-loop/switch region; other site 525381000198 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525381000199 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525381000200 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381000201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381000202 Walker A/P-loop; other site 525381000203 ATP binding site [chemical binding]; other site 525381000204 Q-loop/lid; other site 525381000205 ABC transporter signature motif; other site 525381000206 Walker B; other site 525381000207 D-loop; other site 525381000208 H-loop/switch region; other site 525381000209 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 525381000210 MutS domain I; Region: MutS_I; pfam01624 525381000211 MutS domain II; Region: MutS_II; pfam05188 525381000212 MutS domain III; Region: MutS_III; pfam05192 525381000213 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 525381000214 Walker A/P-loop; other site 525381000215 ATP binding site [chemical binding]; other site 525381000216 Q-loop/lid; other site 525381000217 ABC transporter signature motif; other site 525381000218 Walker B; other site 525381000219 D-loop; other site 525381000220 H-loop/switch region; other site 525381000221 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 525381000222 arginine repressor; Region: argR_whole; TIGR01529 525381000223 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 525381000224 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 525381000225 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 525381000226 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 525381000227 active site 525381000228 HIGH motif; other site 525381000229 KMSK motif region; other site 525381000230 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 525381000231 tRNA binding surface [nucleotide binding]; other site 525381000232 anticodon binding site; other site 525381000233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 525381000234 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 525381000235 Uncharacterized conserved protein [Function unknown]; Region: COG3542 525381000236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525381000237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381000238 active site 525381000239 phosphorylation site [posttranslational modification] 525381000240 intermolecular recognition site; other site 525381000241 dimerization interface [polypeptide binding]; other site 525381000242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525381000243 DNA binding site [nucleotide binding] 525381000244 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525381000245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525381000246 dimer interface [polypeptide binding]; other site 525381000247 phosphorylation site [posttranslational modification] 525381000248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381000249 ATP binding site [chemical binding]; other site 525381000250 G-X-G motif; other site 525381000251 PBP superfamily domain; Region: PBP_like_2; cl17296 525381000252 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 525381000253 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 525381000254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381000255 dimer interface [polypeptide binding]; other site 525381000256 conserved gate region; other site 525381000257 putative PBP binding loops; other site 525381000258 ABC-ATPase subunit interface; other site 525381000259 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 525381000260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381000261 dimer interface [polypeptide binding]; other site 525381000262 conserved gate region; other site 525381000263 putative PBP binding loops; other site 525381000264 ABC-ATPase subunit interface; other site 525381000265 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 525381000266 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 525381000267 Walker A/P-loop; other site 525381000268 ATP binding site [chemical binding]; other site 525381000269 Q-loop/lid; other site 525381000270 ABC transporter signature motif; other site 525381000271 Walker B; other site 525381000272 D-loop; other site 525381000273 H-loop/switch region; other site 525381000274 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 525381000275 PhoU domain; Region: PhoU; pfam01895 525381000276 PhoU domain; Region: PhoU; pfam01895 525381000277 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 525381000278 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525381000279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381000280 non-specific DNA binding site [nucleotide binding]; other site 525381000281 salt bridge; other site 525381000282 sequence-specific DNA binding site [nucleotide binding]; other site 525381000283 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 525381000284 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 525381000285 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 525381000286 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 525381000287 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 525381000288 active site 525381000289 tetramer interface; other site 525381000290 Rhomboid family; Region: Rhomboid; pfam01694 525381000291 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 525381000292 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 525381000293 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 525381000294 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 525381000295 metal binding site [ion binding]; metal-binding site 525381000296 putative dimer interface [polypeptide binding]; other site 525381000297 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 525381000298 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 525381000299 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 525381000300 trimer interface [polypeptide binding]; other site 525381000301 active site 525381000302 substrate binding site [chemical binding]; other site 525381000303 CoA binding site [chemical binding]; other site 525381000304 EamA-like transporter family; Region: EamA; pfam00892 525381000305 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 525381000306 Transglycosylase; Region: Transgly; pfam00912 525381000307 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 525381000308 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 525381000309 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 525381000310 active site 525381000311 HIGH motif; other site 525381000312 dimer interface [polypeptide binding]; other site 525381000313 KMSKS motif; other site 525381000314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525381000315 RNA binding surface [nucleotide binding]; other site 525381000316 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 525381000317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525381000318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381000319 motif II; other site 525381000320 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 525381000321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381000322 S-adenosylmethionine binding site [chemical binding]; other site 525381000323 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 525381000324 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525381000325 4-alpha-glucanotransferase; Provisional; Region: PRK14508 525381000326 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 525381000327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525381000328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381000329 dimer interface [polypeptide binding]; other site 525381000330 conserved gate region; other site 525381000331 putative PBP binding loops; other site 525381000332 ABC-ATPase subunit interface; other site 525381000333 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525381000334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381000335 dimer interface [polypeptide binding]; other site 525381000336 conserved gate region; other site 525381000337 putative PBP binding loops; other site 525381000338 ABC-ATPase subunit interface; other site 525381000339 Predicted integral membrane protein [Function unknown]; Region: COG5521 525381000340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525381000341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525381000342 DNA binding site [nucleotide binding] 525381000343 domain linker motif; other site 525381000344 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 525381000345 putative dimerization interface [polypeptide binding]; other site 525381000346 putative ligand binding site [chemical binding]; other site 525381000347 Uncharacterized conserved protein [Function unknown]; Region: COG1284 525381000348 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525381000349 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525381000350 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 525381000351 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 525381000352 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 525381000353 dimer interface [polypeptide binding]; other site 525381000354 anticodon binding site; other site 525381000355 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 525381000356 homodimer interface [polypeptide binding]; other site 525381000357 motif 1; other site 525381000358 active site 525381000359 motif 2; other site 525381000360 GAD domain; Region: GAD; pfam02938 525381000361 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 525381000362 motif 3; other site 525381000363 CAAX protease self-immunity; Region: Abi; pfam02517 525381000364 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 525381000365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381000366 non-specific DNA binding site [nucleotide binding]; other site 525381000367 salt bridge; other site 525381000368 sequence-specific DNA binding site [nucleotide binding]; other site 525381000369 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 525381000370 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 525381000371 dimer interface [polypeptide binding]; other site 525381000372 motif 1; other site 525381000373 active site 525381000374 motif 2; other site 525381000375 motif 3; other site 525381000376 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 525381000377 anticodon binding site; other site 525381000378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381000379 non-specific DNA binding site [nucleotide binding]; other site 525381000380 salt bridge; other site 525381000381 sequence-specific DNA binding site [nucleotide binding]; other site 525381000382 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 525381000383 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 525381000384 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 525381000385 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 525381000386 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 525381000387 PYR/PP interface [polypeptide binding]; other site 525381000388 dimer interface [polypeptide binding]; other site 525381000389 TPP binding site [chemical binding]; other site 525381000390 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525381000391 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 525381000392 TPP-binding site [chemical binding]; other site 525381000393 dimer interface [polypeptide binding]; other site 525381000394 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 525381000395 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 525381000396 active site 525381000397 P-loop; other site 525381000398 phosphorylation site [posttranslational modification] 525381000399 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 525381000400 PRD domain; Region: PRD; pfam00874 525381000401 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 525381000402 active site 525381000403 P-loop; other site 525381000404 phosphorylation site [posttranslational modification] 525381000405 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 525381000406 active site 525381000407 phosphorylation site [posttranslational modification] 525381000408 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 525381000409 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 525381000410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 525381000411 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 525381000412 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 525381000413 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 525381000414 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525381000415 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000416 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000417 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000418 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000419 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000420 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000421 Divergent AAA domain; Region: AAA_4; pfam04326 525381000422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 525381000423 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 525381000424 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 525381000425 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 525381000426 putative active site [active] 525381000427 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525381000428 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525381000429 nucleotide binding site [chemical binding]; other site 525381000430 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 525381000431 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 525381000432 active site 525381000433 metal binding site [ion binding]; metal-binding site 525381000434 homodimer interface [polypeptide binding]; other site 525381000435 catalytic site [active] 525381000436 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 525381000437 Uncharacterized conserved protein [Function unknown]; Region: COG3538 525381000438 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 525381000439 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 525381000440 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 525381000441 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 525381000442 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 525381000443 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 525381000444 arginine deiminase; Provisional; Region: PRK01388 525381000445 ornithine carbamoyltransferase; Validated; Region: PRK02102 525381000446 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525381000447 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 525381000448 carbamate kinase; Reviewed; Region: PRK12686 525381000449 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 525381000450 putative substrate binding site [chemical binding]; other site 525381000451 nucleotide binding site [chemical binding]; other site 525381000452 nucleotide binding site [chemical binding]; other site 525381000453 homodimer interface [polypeptide binding]; other site 525381000454 Predicted membrane protein [Function unknown]; Region: COG1288 525381000455 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 525381000456 hypothetical protein; Provisional; Region: PRK07205 525381000457 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 525381000458 active site 525381000459 metal binding site [ion binding]; metal-binding site 525381000460 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 525381000461 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 525381000462 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 525381000463 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 525381000464 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 525381000465 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525381000466 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 525381000467 dimer interface [polypeptide binding]; other site 525381000468 active site 525381000469 metal binding site [ion binding]; metal-binding site 525381000470 L-fucose isomerase; Provisional; Region: fucI; PRK10991 525381000471 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 525381000472 hexamer (dimer of trimers) interface [polypeptide binding]; other site 525381000473 trimer interface [polypeptide binding]; other site 525381000474 substrate binding site [chemical binding]; other site 525381000475 Mn binding site [ion binding]; other site 525381000476 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 525381000477 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 525381000478 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 525381000479 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 525381000480 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 525381000481 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 525381000482 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 525381000483 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 525381000484 active site 525381000485 phosphorylation site [posttranslational modification] 525381000486 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 525381000487 active pocket/dimerization site; other site 525381000488 active site 525381000489 phosphorylation site [posttranslational modification] 525381000490 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 525381000491 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 525381000492 intersubunit interface [polypeptide binding]; other site 525381000493 active site 525381000494 Zn2+ binding site [ion binding]; other site 525381000495 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 525381000496 N- and C-terminal domain interface [polypeptide binding]; other site 525381000497 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 525381000498 active site 525381000499 putative catalytic site [active] 525381000500 metal binding site [ion binding]; metal-binding site 525381000501 ATP binding site [chemical binding]; other site 525381000502 carbohydrate binding site [chemical binding]; other site 525381000503 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 525381000504 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 525381000505 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 525381000506 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 525381000507 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 525381000508 metal binding site [ion binding]; metal-binding site 525381000509 YodA lipocalin-like domain; Region: YodA; pfam09223 525381000510 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 525381000511 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525381000512 ABC-ATPase subunit interface; other site 525381000513 dimer interface [polypeptide binding]; other site 525381000514 putative PBP binding regions; other site 525381000515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525381000516 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 525381000517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525381000518 putative DNA binding site [nucleotide binding]; other site 525381000519 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 525381000520 DltD N-terminal region; Region: DltD_N; pfam04915 525381000521 DltD central region; Region: DltD_M; pfam04918 525381000522 DltD C-terminal region; Region: DltD_C; pfam04914 525381000523 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 525381000524 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 525381000525 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 525381000526 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 525381000527 acyl-activating enzyme (AAE) consensus motif; other site 525381000528 AMP binding site [chemical binding]; other site 525381000529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525381000530 H+ Antiporter protein; Region: 2A0121; TIGR00900 525381000531 putative substrate translocation pore; other site 525381000532 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 525381000533 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 525381000534 putative active site [active] 525381000535 putative NTP binding site [chemical binding]; other site 525381000536 putative nucleic acid binding site [nucleotide binding]; other site 525381000537 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 525381000538 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 525381000539 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 525381000540 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 525381000541 amphipathic channel; other site 525381000542 Asn-Pro-Ala signature motifs; other site 525381000543 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 525381000544 glycerol kinase; Provisional; Region: glpK; PRK00047 525381000545 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 525381000546 N- and C-terminal domain interface [polypeptide binding]; other site 525381000547 active site 525381000548 MgATP binding site [chemical binding]; other site 525381000549 catalytic site [active] 525381000550 metal binding site [ion binding]; metal-binding site 525381000551 glycerol binding site [chemical binding]; other site 525381000552 homotetramer interface [polypeptide binding]; other site 525381000553 homodimer interface [polypeptide binding]; other site 525381000554 FBP binding site [chemical binding]; other site 525381000555 protein IIAGlc interface [polypeptide binding]; other site 525381000556 Mga helix-turn-helix domain; Region: Mga; pfam05043 525381000557 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 525381000558 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 525381000559 dimerization interface [polypeptide binding]; other site 525381000560 domain crossover interface; other site 525381000561 redox-dependent activation switch; other site 525381000562 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 525381000563 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 525381000564 FMN binding site [chemical binding]; other site 525381000565 active site 525381000566 catalytic residues [active] 525381000567 substrate binding site [chemical binding]; other site 525381000568 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 525381000569 RICH domain; Region: RICH; pfam05062 525381000570 RICH domain; Region: RICH; pfam05062 525381000571 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525381000572 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381000573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381000574 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381000575 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 525381000576 RICH domain; Region: RICH; pfam05062 525381000577 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000578 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000579 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000580 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000581 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 525381000582 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 525381000584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525381000585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525381000586 dimerization interface [polypeptide binding]; other site 525381000587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525381000588 dimer interface [polypeptide binding]; other site 525381000589 phosphorylation site [posttranslational modification] 525381000590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381000591 ATP binding site [chemical binding]; other site 525381000592 Mg2+ binding site [ion binding]; other site 525381000593 G-X-G motif; other site 525381000594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525381000595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381000596 active site 525381000597 phosphorylation site [posttranslational modification] 525381000598 intermolecular recognition site; other site 525381000599 dimerization interface [polypeptide binding]; other site 525381000600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525381000601 DNA binding site [nucleotide binding] 525381000602 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 525381000603 Clp amino terminal domain; Region: Clp_N; pfam02861 525381000604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381000605 Walker A motif; other site 525381000606 ATP binding site [chemical binding]; other site 525381000607 Walker B motif; other site 525381000608 arginine finger; other site 525381000609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381000610 Walker A motif; other site 525381000611 ATP binding site [chemical binding]; other site 525381000612 Walker B motif; other site 525381000613 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 525381000614 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 525381000615 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 525381000616 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 525381000617 Walker A/P-loop; other site 525381000618 ATP binding site [chemical binding]; other site 525381000619 Q-loop/lid; other site 525381000620 ABC transporter signature motif; other site 525381000621 Walker B; other site 525381000622 D-loop; other site 525381000623 H-loop/switch region; other site 525381000624 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 525381000625 NMT1/THI5 like; Region: NMT1; pfam09084 525381000626 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 525381000627 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 525381000628 putative PBP binding loops; other site 525381000629 ABC-ATPase subunit interface; other site 525381000630 Uncharacterized conserved protein [Function unknown]; Region: COG0011 525381000631 Surface antigen [General function prediction only]; Region: COG3942 525381000632 CHAP domain; Region: CHAP; pfam05257 525381000633 Bacterial SH3 domain; Region: SH3_5; pfam08460 525381000634 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525381000635 Bacterial SH3 domain; Region: SH3_5; pfam08460 525381000636 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381000637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 525381000638 replicative DNA helicase; Provisional; Region: PRK05748 525381000639 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 525381000640 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 525381000641 Walker A motif; other site 525381000642 ATP binding site [chemical binding]; other site 525381000643 Walker B motif; other site 525381000644 DNA binding loops [nucleotide binding] 525381000645 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 525381000646 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 525381000647 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 525381000648 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 525381000649 DHH family; Region: DHH; pfam01368 525381000650 DHHA1 domain; Region: DHHA1; pfam02272 525381000651 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 525381000652 30S subunit binding site; other site 525381000653 comF family protein; Region: comF; TIGR00201 525381000654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381000655 active site 525381000656 potential frameshift: common BLAST hit: gi|225862024|ref|YP_002743533.1| superfamily II ATP-dependent DNA/RNA helicase required for DNA 525381000657 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 525381000658 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525381000659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525381000660 ATP binding site [chemical binding]; other site 525381000661 putative Mg++ binding site [ion binding]; other site 525381000662 Uncharacterized conserved protein [Function unknown]; Region: COG1739 525381000663 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 525381000664 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 525381000665 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 525381000666 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 525381000667 dimer interface [polypeptide binding]; other site 525381000668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381000669 catalytic residue [active] 525381000670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 525381000671 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 525381000672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381000673 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381000674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 525381000675 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 525381000676 elongation factor Ts; Provisional; Region: tsf; PRK09377 525381000677 UBA/TS-N domain; Region: UBA; pfam00627 525381000678 Elongation factor TS; Region: EF_TS; pfam00889 525381000679 Elongation factor TS; Region: EF_TS; pfam00889 525381000680 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 525381000681 rRNA interaction site [nucleotide binding]; other site 525381000682 S8 interaction site; other site 525381000683 putative laminin-1 binding site; other site 525381000684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 525381000685 Septum formation initiator; Region: DivIC; cl17659 525381000686 Surface antigen [General function prediction only]; Region: COG3942 525381000687 CHAP domain; Region: CHAP; pfam05257 525381000688 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 525381000689 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 525381000690 rod shape-determining protein MreC; Region: MreC; pfam04085 525381000691 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 525381000692 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 525381000693 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525381000694 Walker A/P-loop; other site 525381000695 ATP binding site [chemical binding]; other site 525381000696 Q-loop/lid; other site 525381000697 ABC transporter signature motif; other site 525381000698 Walker B; other site 525381000699 D-loop; other site 525381000700 H-loop/switch region; other site 525381000701 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 525381000702 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525381000703 Walker A/P-loop; other site 525381000704 ATP binding site [chemical binding]; other site 525381000705 Q-loop/lid; other site 525381000706 ABC transporter signature motif; other site 525381000707 Walker B; other site 525381000708 D-loop; other site 525381000709 H-loop/switch region; other site 525381000710 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 525381000711 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 525381000712 Helix-turn-helix domain; Region: HTH_25; pfam13413 525381000713 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 525381000714 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 525381000715 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 525381000716 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 525381000717 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 525381000718 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 525381000719 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 525381000720 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 525381000721 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 525381000722 Walker A/P-loop; other site 525381000723 ATP binding site [chemical binding]; other site 525381000724 Q-loop/lid; other site 525381000725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381000726 ABC transporter signature motif; other site 525381000727 Walker B; other site 525381000728 D-loop; other site 525381000729 H-loop/switch region; other site 525381000730 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 525381000731 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 525381000732 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 525381000733 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 525381000734 active site 525381000735 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 525381000736 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 525381000737 active site 525381000738 HIGH motif; other site 525381000739 dimer interface [polypeptide binding]; other site 525381000740 KMSKS motif; other site 525381000741 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 525381000742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381000743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381000744 ABC transporter; Region: ABC_tran_2; pfam12848 525381000745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381000746 Predicted membrane protein [Function unknown]; Region: COG4485 525381000747 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 525381000748 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 525381000749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525381000750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525381000751 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 525381000752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381000753 active site 525381000754 phosphorylation site [posttranslational modification] 525381000755 intermolecular recognition site; other site 525381000756 dimerization interface [polypeptide binding]; other site 525381000757 LytTr DNA-binding domain; Region: LytTR; pfam04397 525381000758 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 525381000759 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 525381000760 COMC family; Region: ComC; pfam03047 525381000761 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 525381000762 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 525381000763 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 525381000764 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525381000765 protein binding site [polypeptide binding]; other site 525381000766 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 525381000767 ParB-like nuclease domain; Region: ParBc; pfam02195 525381000768 KorB domain; Region: KorB; pfam08535 525381000769 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 525381000770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381000771 Walker A motif; other site 525381000772 ATP binding site [chemical binding]; other site 525381000773 Walker B motif; other site 525381000774 arginine finger; other site 525381000775 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 525381000776 DnaA box-binding interface [nucleotide binding]; other site 525381000777 DNA polymerase III subunit beta; Validated; Region: PRK05643 525381000778 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 525381000779 putative DNA binding surface [nucleotide binding]; other site 525381000780 dimer interface [polypeptide binding]; other site 525381000781 beta-clamp/clamp loader binding surface; other site 525381000782 beta-clamp/translesion DNA polymerase binding surface; other site 525381000783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 525381000784 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 525381000785 D5 N terminal like; Region: D5_N; smart00885 525381000786 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 525381000787 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 525381000788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 525381000789 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 525381000790 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 525381000791 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 525381000792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381000793 sequence-specific DNA binding site [nucleotide binding]; other site 525381000794 salt bridge; other site 525381000795 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525381000796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381000797 non-specific DNA binding site [nucleotide binding]; other site 525381000798 salt bridge; other site 525381000799 sequence-specific DNA binding site [nucleotide binding]; other site 525381000800 Predicted transcriptional regulator [Transcription]; Region: COG2932 525381000801 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 525381000802 Catalytic site [active] 525381000803 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 525381000804 Fic family protein [Function unknown]; Region: COG3177 525381000805 Fic/DOC family; Region: Fic; pfam02661 525381000806 Replication protein; Region: Rep_1; cl02412 525381000807 BRO family, N-terminal domain; Region: Bro-N; pfam02498 525381000808 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 525381000809 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 525381000810 Int/Topo IB signature motif; other site 525381000811 GTP-binding protein YchF; Reviewed; Region: PRK09601 525381000812 YchF GTPase; Region: YchF; cd01900 525381000813 G1 box; other site 525381000814 GTP/Mg2+ binding site [chemical binding]; other site 525381000815 Switch I region; other site 525381000816 G2 box; other site 525381000817 Switch II region; other site 525381000818 G3 box; other site 525381000819 G4 box; other site 525381000820 G5 box; other site 525381000821 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 525381000822 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 525381000823 putative active site [active] 525381000824 catalytic residue [active] 525381000825 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 525381000826 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 525381000827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525381000828 ATP binding site [chemical binding]; other site 525381000829 putative Mg++ binding site [ion binding]; other site 525381000830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525381000831 nucleotide binding region [chemical binding]; other site 525381000832 ATP-binding site [chemical binding]; other site 525381000833 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 525381000834 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525381000835 RNA binding surface [nucleotide binding]; other site 525381000836 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 525381000837 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 525381000838 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 525381000839 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 525381000840 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 525381000841 Ligand Binding Site [chemical binding]; other site 525381000842 TilS substrate C-terminal domain; Region: TilS_C; smart00977 525381000843 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381000844 active site 525381000845 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 525381000846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381000847 Walker A motif; other site 525381000848 ATP binding site [chemical binding]; other site 525381000849 Walker B motif; other site 525381000850 arginine finger; other site 525381000851 Peptidase family M41; Region: Peptidase_M41; pfam01434 525381000852 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 525381000853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381000854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381000855 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 525381000856 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 525381000857 GDP-binding site [chemical binding]; other site 525381000858 ACT binding site; other site 525381000859 IMP binding site; other site 525381000860 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 525381000861 nucleoside/Zn binding site; other site 525381000862 dimer interface [polypeptide binding]; other site 525381000863 catalytic motif [active] 525381000864 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 525381000865 trimer interface [polypeptide binding]; other site 525381000866 active site 525381000867 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525381000868 catalytic core [active] 525381000869 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525381000870 DNA repair protein RadA; Provisional; Region: PRK11823 525381000871 Walker A motif; other site 525381000872 ATP binding site [chemical binding]; other site 525381000873 Walker B motif; other site 525381000874 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 525381000875 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 525381000876 active site clefts [active] 525381000877 zinc binding site [ion binding]; other site 525381000878 dimer interface [polypeptide binding]; other site 525381000879 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 525381000880 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 525381000881 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 525381000882 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381000883 active site 525381000884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381000885 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 525381000886 DNA polymerase I; Provisional; Region: PRK05755 525381000887 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 525381000888 active site 525381000889 metal binding site 1 [ion binding]; metal-binding site 525381000890 putative 5' ssDNA interaction site; other site 525381000891 metal binding site 3; metal-binding site 525381000892 metal binding site 2 [ion binding]; metal-binding site 525381000893 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 525381000894 putative DNA binding site [nucleotide binding]; other site 525381000895 putative metal binding site [ion binding]; other site 525381000896 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 525381000897 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 525381000898 active site 525381000899 DNA binding site [nucleotide binding] 525381000900 catalytic site [active] 525381000901 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 525381000902 Predicted membrane protein [Function unknown]; Region: COG2855 525381000903 aromatic amino acid aminotransferase; Validated; Region: PRK07309 525381000904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525381000905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381000906 homodimer interface [polypeptide binding]; other site 525381000907 catalytic residue [active] 525381000908 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 525381000909 Recombination protein O N terminal; Region: RecO_N; pfam11967 525381000910 Recombination protein O C terminal; Region: RecO_C; pfam02565 525381000911 putative phosphate acyltransferase; Provisional; Region: PRK05331 525381000912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 525381000913 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 525381000914 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 525381000915 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 525381000916 putative active site [active] 525381000917 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381000918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381000919 Walker A/P-loop; other site 525381000920 ATP binding site [chemical binding]; other site 525381000921 Q-loop/lid; other site 525381000922 ABC transporter signature motif; other site 525381000923 Walker B; other site 525381000924 D-loop; other site 525381000925 H-loop/switch region; other site 525381000926 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 525381000927 HlyD family secretion protein; Region: HlyD_3; pfam13437 525381000928 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 525381000929 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 525381000930 ATP binding site [chemical binding]; other site 525381000931 active site 525381000932 substrate binding site [chemical binding]; other site 525381000933 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 525381000934 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 525381000935 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 525381000936 dimerization interface [polypeptide binding]; other site 525381000937 ATP binding site [chemical binding]; other site 525381000938 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 525381000939 dimerization interface [polypeptide binding]; other site 525381000940 ATP binding site [chemical binding]; other site 525381000941 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 525381000942 putative active site [active] 525381000943 catalytic triad [active] 525381000944 amidophosphoribosyltransferase; Provisional; Region: PRK07272 525381000945 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 525381000946 active site 525381000947 tetramer interface [polypeptide binding]; other site 525381000948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381000949 active site 525381000950 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 525381000951 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 525381000952 dimerization interface [polypeptide binding]; other site 525381000953 putative ATP binding site [chemical binding]; other site 525381000954 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 525381000955 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 525381000956 active site 525381000957 substrate binding site [chemical binding]; other site 525381000958 cosubstrate binding site; other site 525381000959 catalytic site [active] 525381000960 VanZ like family; Region: VanZ; pfam04892 525381000961 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 525381000962 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 525381000963 purine monophosphate binding site [chemical binding]; other site 525381000964 dimer interface [polypeptide binding]; other site 525381000965 putative catalytic residues [active] 525381000966 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 525381000967 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 525381000968 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 525381000969 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 525381000970 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 525381000971 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 525381000972 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 525381000973 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 525381000974 ATP-grasp domain; Region: ATP-grasp; pfam02222 525381000975 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 525381000976 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 525381000977 tetramer interface [polypeptide binding]; other site 525381000978 active site 525381000979 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 525381000980 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 525381000981 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 525381000982 active site 525381000983 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 525381000984 active site 525381000985 G5 domain; Region: G5; pfam07501 525381000986 G5 domain; Region: G5; pfam07501 525381000987 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 525381000988 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 525381000989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525381000990 DNA-binding site [nucleotide binding]; DNA binding site 525381000991 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 525381000992 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 525381000993 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 525381000994 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 525381000995 active site 525381000996 phosphorylation site [posttranslational modification] 525381000997 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 525381000998 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 525381000999 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 525381001000 active pocket/dimerization site; other site 525381001001 active site 525381001002 phosphorylation site [posttranslational modification] 525381001003 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 525381001004 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 525381001005 dimer interface [polypeptide binding]; other site 525381001006 active site 525381001007 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 525381001008 putative active site [active] 525381001009 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 525381001010 active site 525381001011 catalytic residues [active] 525381001012 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 525381001013 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 525381001014 putative metal binding site [ion binding]; other site 525381001015 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 525381001016 active site 525381001017 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 525381001018 putative homodimer interface [polypeptide binding]; other site 525381001019 putative homotetramer interface [polypeptide binding]; other site 525381001020 putative metal binding site [ion binding]; other site 525381001021 putative homodimer-homodimer interface [polypeptide binding]; other site 525381001022 putative allosteric switch controlling residues; other site 525381001023 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525381001024 active site residue [active] 525381001025 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 525381001026 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 525381001027 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 525381001028 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 525381001029 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 525381001030 TrkA-N domain; Region: TrkA_N; pfam02254 525381001031 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525381001032 active site 525381001033 Fibronectin-binding repeat; Region: SSURE; pfam11966 525381001034 Fibronectin-binding repeat; Region: SSURE; pfam11966 525381001035 Fibronectin-binding repeat; Region: SSURE; pfam11966 525381001036 Fibronectin-binding repeat; Region: SSURE; pfam11966 525381001037 Fibronectin-binding repeat; Region: SSURE; pfam11966 525381001038 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525381001039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381001040 active site 525381001041 phosphorylation site [posttranslational modification] 525381001042 intermolecular recognition site; other site 525381001043 dimerization interface [polypeptide binding]; other site 525381001044 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525381001045 DNA binding site [nucleotide binding] 525381001046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525381001047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525381001048 dimerization interface [polypeptide binding]; other site 525381001049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525381001050 dimer interface [polypeptide binding]; other site 525381001051 phosphorylation site [posttranslational modification] 525381001052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381001053 ATP binding site [chemical binding]; other site 525381001054 Mg2+ binding site [ion binding]; other site 525381001055 G-X-G motif; other site 525381001056 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 525381001057 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 525381001058 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525381001059 RNA binding surface [nucleotide binding]; other site 525381001060 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381001061 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 525381001062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381001063 dimer interface [polypeptide binding]; other site 525381001064 conserved gate region; other site 525381001065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525381001066 ABC-ATPase subunit interface; other site 525381001067 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525381001068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381001069 dimer interface [polypeptide binding]; other site 525381001070 conserved gate region; other site 525381001071 putative PBP binding loops; other site 525381001072 ABC-ATPase subunit interface; other site 525381001073 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525381001074 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 525381001075 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 525381001076 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 525381001077 active site residue [active] 525381001078 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 525381001079 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 525381001080 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381001081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 525381001082 Walker B; other site 525381001083 D-loop; other site 525381001084 H-loop/switch region; other site 525381001085 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 525381001086 Predicted membrane protein [Function unknown]; Region: COG4709 525381001087 Predicted transcriptional regulators [Transcription]; Region: COG1695 525381001088 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 525381001089 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 525381001090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525381001091 putative substrate translocation pore; other site 525381001092 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 525381001093 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525381001094 Ligand binding site; other site 525381001095 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 525381001096 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 525381001097 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 525381001098 NAD(P) binding site [chemical binding]; other site 525381001099 homodimer interface [polypeptide binding]; other site 525381001100 substrate binding site [chemical binding]; other site 525381001101 active site 525381001102 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 525381001103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381001104 motif II; other site 525381001105 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 525381001106 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 525381001107 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 525381001108 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 525381001109 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 525381001110 putative L-serine binding site [chemical binding]; other site 525381001111 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 525381001112 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525381001113 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 525381001114 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 525381001115 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525381001116 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 525381001117 Walker A/P-loop; other site 525381001118 ATP binding site [chemical binding]; other site 525381001119 Q-loop/lid; other site 525381001120 ABC transporter signature motif; other site 525381001121 Walker B; other site 525381001122 D-loop; other site 525381001123 H-loop/switch region; other site 525381001124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381001125 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525381001126 substrate binding pocket [chemical binding]; other site 525381001127 membrane-bound complex binding site; other site 525381001128 hinge residues; other site 525381001129 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 525381001130 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525381001131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381001132 non-specific DNA binding site [nucleotide binding]; other site 525381001133 salt bridge; other site 525381001134 sequence-specific DNA binding site [nucleotide binding]; other site 525381001135 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 525381001136 putative active site [active] 525381001137 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 525381001138 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381001139 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381001140 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381001141 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381001142 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381001143 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 525381001144 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381001145 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381001146 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 525381001147 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 525381001148 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 525381001149 nudix motif; other site 525381001150 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 525381001151 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 525381001152 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 525381001153 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 525381001154 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 525381001155 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 525381001156 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 525381001157 hypothetical protein; Provisional; Region: PRK13667 525381001158 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 525381001159 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 525381001160 Glycoprotease family; Region: Peptidase_M22; pfam00814 525381001161 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 525381001162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381001163 Coenzyme A binding pocket [chemical binding]; other site 525381001164 UGMP family protein; Validated; Region: PRK09604 525381001165 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 525381001166 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 525381001167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381001168 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381001169 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525381001170 Helix-turn-helix domain; Region: HTH_38; pfam13936 525381001171 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381001172 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381001173 Winged helix-turn helix; Region: HTH_33; pfam13592 525381001174 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525381001175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525381001176 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525381001177 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525381001178 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525381001179 active site 525381001180 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381001181 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 525381001182 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525381001183 Walker A/P-loop; other site 525381001184 ATP binding site [chemical binding]; other site 525381001185 Q-loop/lid; other site 525381001186 ABC transporter signature motif; other site 525381001187 Walker B; other site 525381001188 D-loop; other site 525381001189 H-loop/switch region; other site 525381001190 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 525381001191 potential frameshift: common BLAST hit: gi|182683112|ref|YP_001834859.1| UDP-glucose dehydrogenase 525381001192 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 525381001193 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 525381001194 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 525381001195 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 525381001196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525381001197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381001198 non-specific DNA binding site [nucleotide binding]; other site 525381001199 salt bridge; other site 525381001200 sequence-specific DNA binding site [nucleotide binding]; other site 525381001201 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 525381001202 CAAX protease self-immunity; Region: Abi; pfam02517 525381001203 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 525381001204 Predicted membrane protein [Function unknown]; Region: COG4392 525381001205 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525381001206 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381001207 substrate binding pocket [chemical binding]; other site 525381001208 membrane-bound complex binding site; other site 525381001209 hinge residues; other site 525381001210 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 525381001211 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 525381001212 hypothetical protein; Provisional; Region: PRK06446 525381001213 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 525381001214 metal binding site [ion binding]; metal-binding site 525381001215 dimer interface [polypeptide binding]; other site 525381001216 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 525381001217 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 525381001218 Walker A/P-loop; other site 525381001219 ATP binding site [chemical binding]; other site 525381001220 Q-loop/lid; other site 525381001221 ABC transporter signature motif; other site 525381001222 Walker B; other site 525381001223 D-loop; other site 525381001224 H-loop/switch region; other site 525381001225 NIL domain; Region: NIL; pfam09383 525381001226 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 525381001227 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 525381001228 Predicted integral membrane protein [Function unknown]; Region: COG5578 525381001229 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 525381001230 HAMP domain; Region: HAMP; pfam00672 525381001231 Histidine kinase; Region: His_kinase; pfam06580 525381001232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381001233 ATP binding site [chemical binding]; other site 525381001234 Mg2+ binding site [ion binding]; other site 525381001235 G-X-G motif; other site 525381001236 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 525381001237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381001238 active site 525381001239 phosphorylation site [posttranslational modification] 525381001240 intermolecular recognition site; other site 525381001241 dimerization interface [polypeptide binding]; other site 525381001242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525381001243 flavoprotein NrdI; Provisional; Region: PRK02551 525381001244 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 525381001245 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 525381001246 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 525381001247 LytTr DNA-binding domain; Region: LytTR; smart00850 525381001248 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 525381001249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381001250 ATP binding site [chemical binding]; other site 525381001251 Mg2+ binding site [ion binding]; other site 525381001252 G-X-G motif; other site 525381001253 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 525381001254 ATP binding site [chemical binding]; other site 525381001255 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 525381001256 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 525381001257 homopentamer interface [polypeptide binding]; other site 525381001258 active site 525381001259 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 525381001260 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 525381001261 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 525381001262 dimerization interface [polypeptide binding]; other site 525381001263 active site 525381001264 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 525381001265 Lumazine binding domain; Region: Lum_binding; pfam00677 525381001266 Lumazine binding domain; Region: Lum_binding; pfam00677 525381001267 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 525381001268 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 525381001269 catalytic motif [active] 525381001270 Zn binding site [ion binding]; other site 525381001271 RibD C-terminal domain; Region: RibD_C; cl17279 525381001272 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 525381001273 RuvA N terminal domain; Region: RuvA_N; pfam01330 525381001274 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 525381001275 CAAX protease self-immunity; Region: Abi; pfam02517 525381001276 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 525381001277 putative dimer interface [polypeptide binding]; other site 525381001278 catalytic triad [active] 525381001279 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 525381001280 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 525381001281 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 525381001282 Cl binding site [ion binding]; other site 525381001283 oligomer interface [polypeptide binding]; other site 525381001284 potential frameshift: common BLAST hit: gi|225860217|ref|YP_002741726.1| prophage Sa05, site-specific recombinase, phage integrase family 525381001285 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 525381001286 Int/Topo IB signature motif; other site 525381001287 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525381001288 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 525381001289 Divergent AAA domain; Region: AAA_4; pfam04326 525381001290 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 525381001291 Penicillinase repressor; Region: Pencillinase_R; cl17580 525381001292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381001293 non-specific DNA binding site [nucleotide binding]; other site 525381001294 salt bridge; other site 525381001295 sequence-specific DNA binding site [nucleotide binding]; other site 525381001296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525381001297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381001298 non-specific DNA binding site [nucleotide binding]; other site 525381001299 salt bridge; other site 525381001300 sequence-specific DNA binding site [nucleotide binding]; other site 525381001301 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 525381001302 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 525381001303 Preprotein translocase subunit; Region: YajC; cl00806 525381001304 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 525381001305 D5 N terminal like; Region: D5_N; smart00885 525381001306 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 525381001307 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 525381001308 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 525381001309 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 525381001310 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 525381001311 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 525381001312 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 525381001313 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 525381001314 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 525381001315 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 525381001316 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 525381001317 active site 525381001318 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 525381001319 ArsC family; Region: ArsC; pfam03960 525381001320 putative catalytic residues [active] 525381001321 thiol/disulfide switch; other site 525381001322 hypothetical protein; Provisional; Region: PRK05473 525381001323 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 525381001324 hypothetical protein; Provisional; Region: PRK13678 525381001325 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 525381001326 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525381001327 Bacterial lipoprotein; Region: DUF3642; pfam12182 525381001328 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 525381001329 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 525381001330 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 525381001331 putative active site [active] 525381001332 catalytic site [active] 525381001333 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 525381001334 putative active site [active] 525381001335 catalytic site [active] 525381001336 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 525381001337 ATP cone domain; Region: ATP-cone; pfam03477 525381001338 Class III ribonucleotide reductase; Region: RNR_III; cd01675 525381001339 effector binding site; other site 525381001340 active site 525381001341 Zn binding site [ion binding]; other site 525381001342 glycine loop; other site 525381001343 Predicted acetyltransferase [General function prediction only]; Region: COG3981 525381001344 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525381001345 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 525381001346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525381001347 FeS/SAM binding site; other site 525381001348 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 525381001349 active site 525381001350 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 525381001351 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 525381001352 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 525381001353 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 525381001354 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 525381001355 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 525381001356 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 525381001357 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 525381001358 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 525381001359 putative translocon binding site; other site 525381001360 protein-rRNA interface [nucleotide binding]; other site 525381001361 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 525381001362 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 525381001363 G-X-X-G motif; other site 525381001364 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 525381001365 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 525381001366 23S rRNA interface [nucleotide binding]; other site 525381001367 5S rRNA interface [nucleotide binding]; other site 525381001368 putative antibiotic binding site [chemical binding]; other site 525381001369 L25 interface [polypeptide binding]; other site 525381001370 L27 interface [polypeptide binding]; other site 525381001371 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 525381001372 23S rRNA interface [nucleotide binding]; other site 525381001373 putative translocon interaction site; other site 525381001374 signal recognition particle (SRP54) interaction site; other site 525381001375 L23 interface [polypeptide binding]; other site 525381001376 trigger factor interaction site; other site 525381001377 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 525381001378 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 525381001379 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 525381001380 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 525381001381 RNA binding site [nucleotide binding]; other site 525381001382 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 525381001383 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 525381001384 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 525381001385 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 525381001386 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 525381001387 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 525381001388 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525381001389 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525381001390 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 525381001391 5S rRNA interface [nucleotide binding]; other site 525381001392 L27 interface [polypeptide binding]; other site 525381001393 23S rRNA interface [nucleotide binding]; other site 525381001394 L5 interface [polypeptide binding]; other site 525381001395 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 525381001396 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 525381001397 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 525381001398 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 525381001399 23S rRNA binding site [nucleotide binding]; other site 525381001400 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 525381001401 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 525381001402 SecY translocase; Region: SecY; pfam00344 525381001403 adenylate kinase; Reviewed; Region: adk; PRK00279 525381001404 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 525381001405 AMP-binding site [chemical binding]; other site 525381001406 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 525381001407 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 525381001408 rRNA binding site [nucleotide binding]; other site 525381001409 predicted 30S ribosome binding site; other site 525381001410 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 525381001411 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 525381001412 30S ribosomal protein S13; Region: bact_S13; TIGR03631 525381001413 30S ribosomal protein S11; Validated; Region: PRK05309 525381001414 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 525381001415 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 525381001416 alphaNTD homodimer interface [polypeptide binding]; other site 525381001417 alphaNTD - beta interaction site [polypeptide binding]; other site 525381001418 alphaNTD - beta' interaction site [polypeptide binding]; other site 525381001419 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 525381001420 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 525381001421 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 525381001422 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 525381001423 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525381001424 catalytic core [active] 525381001425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381001426 putative PBP binding loops; other site 525381001427 dimer interface [polypeptide binding]; other site 525381001428 ABC-ATPase subunit interface; other site 525381001429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525381001430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525381001431 potential frameshift: common BLAST hit: gi|221231146|ref|YP_002510298.1| probable ATP-binding component of ABC transporter 525381001432 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525381001433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381001434 Walker B; other site 525381001435 D-loop; other site 525381001436 H-loop/switch region; other site 525381001437 TOBE domain; Region: TOBE_2; pfam08402 525381001438 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525381001439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381001440 Walker A/P-loop; other site 525381001441 ATP binding site [chemical binding]; other site 525381001442 Q-loop/lid; other site 525381001443 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 525381001444 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 525381001445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525381001446 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 525381001447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525381001448 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 525381001449 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 525381001450 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 525381001451 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 525381001452 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 525381001453 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 525381001454 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 525381001455 active site 525381001456 methionine cluster; other site 525381001457 phosphorylation site [posttranslational modification] 525381001458 metal binding site [ion binding]; metal-binding site 525381001459 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 525381001460 active site 525381001461 P-loop; other site 525381001462 phosphorylation site [posttranslational modification] 525381001463 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 525381001464 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 525381001465 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 525381001466 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 525381001467 dimer interface [polypeptide binding]; other site 525381001468 active site 525381001469 glycine loop; other site 525381001470 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 525381001471 active site 525381001472 intersubunit interactions; other site 525381001473 catalytic residue [active] 525381001474 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 525381001475 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 525381001476 dimer interface [polypeptide binding]; other site 525381001477 active site 525381001478 metal binding site [ion binding]; metal-binding site 525381001479 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 525381001480 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 525381001481 HIGH motif; other site 525381001482 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525381001483 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525381001484 active site 525381001485 KMSKS motif; other site 525381001486 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 525381001487 tRNA binding surface [nucleotide binding]; other site 525381001488 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 525381001489 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525381001490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 525381001491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381001492 Coenzyme A binding pocket [chemical binding]; other site 525381001493 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 525381001494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381001495 Walker A motif; other site 525381001496 ATP binding site [chemical binding]; other site 525381001497 Walker B motif; other site 525381001498 arginine finger; other site 525381001499 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 525381001500 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 525381001501 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 525381001502 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 525381001503 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 525381001504 catalytic residue [active] 525381001505 putative FPP diphosphate binding site; other site 525381001506 putative FPP binding hydrophobic cleft; other site 525381001507 dimer interface [polypeptide binding]; other site 525381001508 putative IPP diphosphate binding site; other site 525381001509 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 525381001510 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 525381001511 RIP metalloprotease RseP; Region: TIGR00054 525381001512 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 525381001513 active site 525381001514 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 525381001515 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 525381001516 putative substrate binding region [chemical binding]; other site 525381001517 prolyl-tRNA synthetase; Provisional; Region: PRK09194 525381001518 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 525381001519 dimer interface [polypeptide binding]; other site 525381001520 motif 1; other site 525381001521 active site 525381001522 motif 2; other site 525381001523 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 525381001524 putative deacylase active site [active] 525381001525 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 525381001526 active site 525381001527 motif 3; other site 525381001528 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 525381001529 anticodon binding site; other site 525381001530 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 525381001531 beta-galactosidase; Region: BGL; TIGR03356 525381001532 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 525381001533 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 525381001534 glutaminase active site [active] 525381001535 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 525381001536 dimer interface [polypeptide binding]; other site 525381001537 active site 525381001538 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 525381001539 dimer interface [polypeptide binding]; other site 525381001540 active site 525381001541 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 525381001542 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 525381001543 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 525381001544 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 525381001545 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 525381001546 carbohydrate binding site [chemical binding]; other site 525381001547 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 525381001548 carbohydrate binding site [chemical binding]; other site 525381001549 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 525381001550 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 525381001551 Ca binding site [ion binding]; other site 525381001552 active site 525381001553 catalytic site [active] 525381001554 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 525381001555 S17 interaction site [polypeptide binding]; other site 525381001556 S8 interaction site; other site 525381001557 16S rRNA interaction site [nucleotide binding]; other site 525381001558 streptomycin interaction site [chemical binding]; other site 525381001559 23S rRNA interaction site [nucleotide binding]; other site 525381001560 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 525381001561 30S ribosomal protein S7; Validated; Region: PRK05302 525381001562 elongation factor G; Reviewed; Region: PRK00007 525381001563 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 525381001564 G1 box; other site 525381001565 putative GEF interaction site [polypeptide binding]; other site 525381001566 GTP/Mg2+ binding site [chemical binding]; other site 525381001567 Switch I region; other site 525381001568 G2 box; other site 525381001569 G3 box; other site 525381001570 Switch II region; other site 525381001571 G4 box; other site 525381001572 G5 box; other site 525381001573 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525381001574 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 525381001575 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525381001576 DNA polymerase III PolC; Validated; Region: polC; PRK00448 525381001577 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 525381001578 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 525381001579 generic binding surface II; other site 525381001580 generic binding surface I; other site 525381001581 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 525381001582 active site 525381001583 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 525381001584 active site 525381001585 catalytic site [active] 525381001586 substrate binding site [chemical binding]; other site 525381001587 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 525381001588 putative PHP Thumb interface [polypeptide binding]; other site 525381001589 active site 525381001590 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 525381001591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 525381001592 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 525381001593 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 525381001594 Predicted membrane protein [Function unknown]; Region: COG2261 525381001595 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 525381001596 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525381001597 RNA binding surface [nucleotide binding]; other site 525381001598 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 525381001599 active site 525381001600 uracil binding [chemical binding]; other site 525381001601 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 525381001602 trimer interface [polypeptide binding]; other site 525381001603 active site 525381001604 G bulge; other site 525381001605 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 525381001606 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 525381001607 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 525381001608 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 525381001609 active pocket/dimerization site; other site 525381001610 active site 525381001611 phosphorylation site [posttranslational modification] 525381001612 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 525381001613 active site 525381001614 phosphorylation site [posttranslational modification] 525381001615 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 525381001616 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 525381001617 NAD binding site [chemical binding]; other site 525381001618 substrate binding site [chemical binding]; other site 525381001619 catalytic Zn binding site [ion binding]; other site 525381001620 tetramer interface [polypeptide binding]; other site 525381001621 structural Zn binding site [ion binding]; other site 525381001622 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 525381001623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381001624 active site 525381001625 motif I; other site 525381001626 motif II; other site 525381001627 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 525381001628 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 525381001629 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 525381001630 dihydropteroate synthase; Region: DHPS; TIGR01496 525381001631 substrate binding pocket [chemical binding]; other site 525381001632 dimer interface [polypeptide binding]; other site 525381001633 inhibitor binding site; inhibition site 525381001634 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 525381001635 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525381001636 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525381001637 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 525381001638 homodecamer interface [polypeptide binding]; other site 525381001639 GTP cyclohydrolase I; Provisional; Region: PLN03044 525381001640 active site 525381001641 putative catalytic site residues [active] 525381001642 zinc binding site [ion binding]; other site 525381001643 GTP-CH-I/GFRP interaction surface; other site 525381001644 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 525381001645 homooctamer interface [polypeptide binding]; other site 525381001646 active site 525381001647 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 525381001648 catalytic center binding site [active] 525381001649 ATP binding site [chemical binding]; other site 525381001650 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 525381001651 ribosomal protein L13 leader; HMPREF0837_nc10007 525381001652 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 525381001653 23S rRNA interface [nucleotide binding]; other site 525381001654 L3 interface [polypeptide binding]; other site 525381001655 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 525381001656 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525381001657 DNA binding site [nucleotide binding] 525381001658 active site 525381001659 Int/Topo IB signature motif; other site 525381001660 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 525381001661 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 525381001662 putative active site [active] 525381001663 putative catalytic site [active] 525381001664 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 525381001665 catalytic residues [active] 525381001666 dimer interface [polypeptide binding]; other site 525381001667 potential frameshift: common BLAST hit: gi|15902330|ref|NP_357880.1| hyaluronate lyase precursor (hyaluronidase/hyase) 525381001668 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 525381001669 substrate binding site [chemical binding]; other site 525381001670 catalytic residues [active] 525381001671 Transposase IS200 like; Region: Y1_Tnp; pfam01797 525381001672 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 525381001673 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 525381001674 active site 525381001675 intersubunit interface [polypeptide binding]; other site 525381001676 catalytic residue [active] 525381001677 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525381001678 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 525381001679 substrate binding site [chemical binding]; other site 525381001680 ATP binding site [chemical binding]; other site 525381001681 hypothetical protein; Provisional; Region: PRK09273 525381001682 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 525381001683 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 525381001684 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 525381001685 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 525381001686 NADP binding site [chemical binding]; other site 525381001687 homodimer interface [polypeptide binding]; other site 525381001688 active site 525381001689 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 525381001690 active pocket/dimerization site; other site 525381001691 active site 525381001692 phosphorylation site [posttranslational modification] 525381001693 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 525381001694 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 525381001695 active site 525381001696 phosphorylation site [posttranslational modification] 525381001697 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 525381001698 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 525381001699 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 525381001700 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 525381001701 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525381001702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525381001703 DNA binding site [nucleotide binding] 525381001704 domain linker motif; other site 525381001705 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 525381001706 putative dimerization interface [polypeptide binding]; other site 525381001707 putative ligand binding site [chemical binding]; other site 525381001708 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 525381001709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381001710 non-specific DNA binding site [nucleotide binding]; other site 525381001711 salt bridge; other site 525381001712 sequence-specific DNA binding site [nucleotide binding]; other site 525381001713 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 525381001714 MraW methylase family; Region: Methyltransf_5; pfam01795 525381001715 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 525381001716 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 525381001717 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525381001718 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525381001719 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 525381001720 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 525381001721 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 525381001722 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 525381001723 Mg++ binding site [ion binding]; other site 525381001724 putative catalytic motif [active] 525381001725 putative substrate binding site [chemical binding]; other site 525381001726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381001727 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525381001728 Walker A motif; other site 525381001729 ATP binding site [chemical binding]; other site 525381001730 Walker B motif; other site 525381001731 arginine finger; other site 525381001732 UvrB/uvrC motif; Region: UVR; pfam02151 525381001733 MoxR-like ATPases [General function prediction only]; Region: COG0714 525381001734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381001735 Walker A motif; other site 525381001736 ATP binding site [chemical binding]; other site 525381001737 Walker B motif; other site 525381001738 arginine finger; other site 525381001739 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 525381001740 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 525381001741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 525381001742 hypothetical protein; Provisional; Region: PRK13663 525381001743 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 525381001744 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 525381001745 Ca binding site [ion binding]; other site 525381001746 active site 525381001747 catalytic site [active] 525381001748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381001749 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381001750 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 525381001751 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 525381001752 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 525381001753 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 525381001754 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 525381001755 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 525381001756 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525381001757 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 525381001758 Bacterial sugar transferase; Region: Bac_transf; pfam02397 525381001759 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 525381001760 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 525381001761 LicD family; Region: LicD; pfam04991 525381001762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525381001763 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 525381001764 active site 525381001765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525381001766 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 525381001767 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 525381001768 active site 525381001769 homodimer interface [polypeptide binding]; other site 525381001770 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 525381001771 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 525381001772 substrate binding site; other site 525381001773 tetramer interface; other site 525381001774 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 525381001775 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 525381001776 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 525381001777 NAD binding site [chemical binding]; other site 525381001778 substrate binding site [chemical binding]; other site 525381001779 homodimer interface [polypeptide binding]; other site 525381001780 active site 525381001781 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 525381001782 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 525381001783 NADP binding site [chemical binding]; other site 525381001784 active site 525381001785 putative substrate binding site [chemical binding]; other site 525381001786 potential frameshift: common BLAST hit: gi|253755842|ref|YP_003028982.1| UDP-galactopyranose mutase 525381001787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525381001788 UDP-galactopyranose mutase; Region: GLF; pfam03275 525381001789 potential frameshift: common BLAST hit: gi|253755842|ref|YP_003028982.1| UDP-galactopyranose mutase 525381001790 UDP-galactopyranose mutase; Region: GLF; pfam03275 525381001791 UDP-galactopyranose mutase; Region: GLF; pfam03275 525381001792 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 525381001793 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 525381001794 peptide binding site [polypeptide binding]; other site 525381001795 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 525381001796 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 525381001797 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 525381001798 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 525381001799 Transglycosylase; Region: Transgly; pfam00912 525381001800 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 525381001801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 525381001802 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 525381001803 hypothetical protein; Provisional; Region: PRK13660 525381001804 cell division protein GpsB; Provisional; Region: PRK14127 525381001805 DivIVA domain; Region: DivI1A_domain; TIGR03544 525381001806 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 525381001807 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 525381001808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 525381001809 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 525381001810 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 525381001811 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 525381001812 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525381001813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381001814 active site 525381001815 phosphorylation site [posttranslational modification] 525381001816 intermolecular recognition site; other site 525381001817 dimerization interface [polypeptide binding]; other site 525381001818 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525381001819 DNA binding site [nucleotide binding] 525381001820 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525381001821 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525381001822 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 525381001823 active site 525381001824 zinc binding site [ion binding]; other site 525381001825 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 525381001826 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 525381001827 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 525381001828 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 525381001829 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 525381001830 diphosphomevalonate decarboxylase; Region: PLN02407 525381001831 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 525381001832 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 525381001833 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 525381001834 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 525381001835 homotetramer interface [polypeptide binding]; other site 525381001836 FMN binding site [chemical binding]; other site 525381001837 homodimer contacts [polypeptide binding]; other site 525381001838 putative active site [active] 525381001839 putative substrate binding site [chemical binding]; other site 525381001840 Predicted membrane protein [Function unknown]; Region: COG4758 525381001841 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 525381001842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525381001843 Histidine kinase; Region: HisKA_3; pfam07730 525381001844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381001845 ATP binding site [chemical binding]; other site 525381001846 Mg2+ binding site [ion binding]; other site 525381001847 G-X-G motif; other site 525381001848 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525381001849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381001850 active site 525381001851 phosphorylation site [posttranslational modification] 525381001852 intermolecular recognition site; other site 525381001853 dimerization interface [polypeptide binding]; other site 525381001854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525381001855 DNA binding residues [nucleotide binding] 525381001856 dimerization interface [polypeptide binding]; other site 525381001857 A new structural DNA glycosylase; Region: AlkD_like; cl11434 525381001858 A new structural DNA glycosylase; Region: AlkD_like; cl11434 525381001859 A new structural DNA glycosylase; Region: AlkD_like; cl11434 525381001860 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 525381001861 active site 525381001862 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 525381001863 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525381001864 DNA binding site [nucleotide binding] 525381001865 Int/Topo IB signature motif; other site 525381001866 active site 525381001867 trigger factor; Provisional; Region: tig; PRK01490 525381001868 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 525381001869 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 525381001870 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 525381001871 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 525381001872 DNA binding site [nucleotide binding] 525381001873 AAA domain; Region: AAA_30; pfam13604 525381001874 Family description; Region: UvrD_C_2; pfam13538 525381001875 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 525381001876 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 525381001877 Catalytic site [active] 525381001878 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 525381001879 ribonuclease HIII; Provisional; Region: PRK00996 525381001880 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 525381001881 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 525381001882 RNA/DNA hybrid binding site [nucleotide binding]; other site 525381001883 active site 525381001884 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 525381001885 Colicin V production protein; Region: Colicin_V; pfam02674 525381001886 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 525381001887 MutS domain III; Region: MutS_III; pfam05192 525381001888 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 525381001889 Walker A/P-loop; other site 525381001890 ATP binding site [chemical binding]; other site 525381001891 Q-loop/lid; other site 525381001892 ABC transporter signature motif; other site 525381001893 Walker B; other site 525381001894 D-loop; other site 525381001895 H-loop/switch region; other site 525381001896 Smr domain; Region: Smr; pfam01713 525381001897 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 525381001898 amino acid carrier protein; Region: agcS; TIGR00835 525381001899 Uncharacterized conserved protein [Function unknown]; Region: COG2128 525381001900 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 525381001901 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 525381001902 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 525381001903 gating phenylalanine in ion channel; other site 525381001904 seryl-tRNA synthetase; Provisional; Region: PRK05431 525381001905 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 525381001906 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 525381001907 dimer interface [polypeptide binding]; other site 525381001908 active site 525381001909 motif 1; other site 525381001910 motif 2; other site 525381001911 motif 3; other site 525381001912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 525381001913 aspartate kinase; Reviewed; Region: PRK09034 525381001914 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 525381001915 putative catalytic residues [active] 525381001916 putative nucleotide binding site [chemical binding]; other site 525381001917 putative aspartate binding site [chemical binding]; other site 525381001918 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 525381001919 allosteric regulatory residue; other site 525381001920 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 525381001921 enoyl-CoA hydratase; Provisional; Region: PRK07260 525381001922 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 525381001923 substrate binding site [chemical binding]; other site 525381001924 oxyanion hole (OAH) forming residues; other site 525381001925 trimer interface [polypeptide binding]; other site 525381001926 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 525381001927 MarR family; Region: MarR_2; pfam12802 525381001928 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 525381001929 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 525381001930 dimer interface [polypeptide binding]; other site 525381001931 active site 525381001932 CoA binding pocket [chemical binding]; other site 525381001933 acyl carrier protein; Provisional; Region: acpP; PRK00982 525381001934 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 525381001935 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 525381001936 FMN binding site [chemical binding]; other site 525381001937 substrate binding site [chemical binding]; other site 525381001938 putative catalytic residue [active] 525381001939 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 525381001940 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 525381001941 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 525381001942 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 525381001943 NAD(P) binding site [chemical binding]; other site 525381001944 homotetramer interface [polypeptide binding]; other site 525381001945 homodimer interface [polypeptide binding]; other site 525381001946 active site 525381001947 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 525381001948 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 525381001949 dimer interface [polypeptide binding]; other site 525381001950 active site 525381001951 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 525381001952 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 525381001953 carboxyltransferase (CT) interaction site; other site 525381001954 biotinylation site [posttranslational modification]; other site 525381001955 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 525381001956 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 525381001957 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525381001958 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 525381001959 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 525381001960 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 525381001961 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 525381001962 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 525381001963 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 525381001964 CAAX protease self-immunity; Region: Abi; pfam02517 525381001965 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 525381001966 putative RNA binding site [nucleotide binding]; other site 525381001967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 525381001968 elongation factor P; Validated; Region: PRK00529 525381001969 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 525381001970 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 525381001971 RNA binding site [nucleotide binding]; other site 525381001972 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 525381001973 RNA binding site [nucleotide binding]; other site 525381001974 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 525381001975 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 525381001976 putative NAD(P) binding site [chemical binding]; other site 525381001977 catalytic Zn binding site [ion binding]; other site 525381001978 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 525381001979 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 525381001980 GatB domain; Region: GatB_Yqey; pfam02637 525381001981 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 525381001982 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 525381001983 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 525381001984 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 525381001985 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 525381001986 G1 box; other site 525381001987 putative GEF interaction site [polypeptide binding]; other site 525381001988 GTP/Mg2+ binding site [chemical binding]; other site 525381001989 Switch I region; other site 525381001990 G2 box; other site 525381001991 G3 box; other site 525381001992 Switch II region; other site 525381001993 G4 box; other site 525381001994 G5 box; other site 525381001995 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 525381001996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525381001997 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 525381001998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 525381001999 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 525381002000 DAK2 domain; Region: Dak2; pfam02734 525381002001 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 525381002002 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 525381002003 PYR/PP interface [polypeptide binding]; other site 525381002004 dimer interface [polypeptide binding]; other site 525381002005 TPP binding site [chemical binding]; other site 525381002006 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 525381002007 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 525381002008 TPP-binding site [chemical binding]; other site 525381002009 dimer interface [polypeptide binding]; other site 525381002010 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 525381002011 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 525381002012 putative valine binding site [chemical binding]; other site 525381002013 dimer interface [polypeptide binding]; other site 525381002014 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 525381002015 ketol-acid reductoisomerase; Provisional; Region: PRK05479 525381002016 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 525381002017 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 525381002018 threonine dehydratase; Validated; Region: PRK08639 525381002019 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 525381002020 tetramer interface [polypeptide binding]; other site 525381002021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381002022 catalytic residue [active] 525381002023 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 525381002024 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525381002025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002026 Walker A/P-loop; other site 525381002027 ATP binding site [chemical binding]; other site 525381002028 Q-loop/lid; other site 525381002029 ABC transporter signature motif; other site 525381002030 Walker B; other site 525381002031 D-loop; other site 525381002032 H-loop/switch region; other site 525381002033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381002034 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525381002035 substrate binding pocket [chemical binding]; other site 525381002036 membrane-bound complex binding site; other site 525381002037 hinge residues; other site 525381002038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381002039 dimer interface [polypeptide binding]; other site 525381002040 conserved gate region; other site 525381002041 putative PBP binding loops; other site 525381002042 ABC-ATPase subunit interface; other site 525381002043 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 525381002044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 525381002045 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525381002046 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525381002047 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 525381002048 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 525381002049 active site 525381002050 DNA polymerase IV; Validated; Region: PRK02406 525381002051 DNA binding site [nucleotide binding] 525381002052 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 525381002053 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 525381002054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381002055 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381002056 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 525381002057 Mga helix-turn-helix domain; Region: Mga; pfam05043 525381002058 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 525381002059 Cna protein B-type domain; Region: Cna_B; pfam05738 525381002060 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 525381002061 metal ion-dependent adhesion site (MIDAS); other site 525381002062 Cna protein B-type domain; Region: Cna_B; pfam05738 525381002063 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 525381002064 Cna protein B-type domain; Region: Cna_B; pfam05738 525381002065 Cna protein B-type domain; Region: Cna_B; pfam05738 525381002066 Cna protein B-type domain; Region: Cna_B; pfam05738 525381002067 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 525381002068 active site 525381002069 catalytic site [active] 525381002070 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 525381002071 active site 525381002072 catalytic site [active] 525381002073 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 525381002074 active site 525381002075 catalytic site [active] 525381002076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381002077 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381002078 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525381002079 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381002080 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 525381002081 Transcriptional regulators [Transcription]; Region: MarR; COG1846 525381002082 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 525381002083 non-specific DNA interactions [nucleotide binding]; other site 525381002084 DNA binding site [nucleotide binding] 525381002085 sequence specific DNA binding site [nucleotide binding]; other site 525381002086 putative cAMP binding site [chemical binding]; other site 525381002087 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525381002088 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 525381002089 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 525381002090 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 525381002091 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 525381002092 methionine cluster; other site 525381002093 active site 525381002094 phosphorylation site [posttranslational modification] 525381002095 metal binding site [ion binding]; metal-binding site 525381002096 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 525381002097 beta-galactosidase; Region: BGL; TIGR03356 525381002098 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 525381002099 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 525381002100 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 525381002101 active site 525381002102 P-loop; other site 525381002103 phosphorylation site [posttranslational modification] 525381002104 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 525381002105 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 525381002106 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 525381002107 TrkA-N domain; Region: TrkA_N; pfam02254 525381002108 TrkA-C domain; Region: TrkA_C; pfam02080 525381002109 TrkA-N domain; Region: TrkA_N; pfam02254 525381002110 TrkA-C domain; Region: TrkA_C; pfam02080 525381002111 Uncharacterized conserved protein [Function unknown]; Region: COG1912 525381002112 hypothetical protein; Provisional; Region: PRK13661 525381002113 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525381002114 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525381002115 Walker A/P-loop; other site 525381002116 ATP binding site [chemical binding]; other site 525381002117 Q-loop/lid; other site 525381002118 ABC transporter signature motif; other site 525381002119 Walker B; other site 525381002120 D-loop; other site 525381002121 H-loop/switch region; other site 525381002122 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 525381002123 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525381002124 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525381002125 Walker A/P-loop; other site 525381002126 ATP binding site [chemical binding]; other site 525381002127 Q-loop/lid; other site 525381002128 ABC transporter signature motif; other site 525381002129 Walker B; other site 525381002130 D-loop; other site 525381002131 H-loop/switch region; other site 525381002132 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 525381002133 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 525381002134 Predicted membrane protein [Function unknown]; Region: COG3601 525381002135 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 525381002136 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 525381002137 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 525381002138 active site 525381002139 ParB-like nuclease domain; Region: ParBc; cl02129 525381002140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525381002141 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525381002142 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 525381002143 CTP synthetase; Validated; Region: pyrG; PRK05380 525381002144 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 525381002145 Catalytic site [active] 525381002146 active site 525381002147 UTP binding site [chemical binding]; other site 525381002148 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 525381002149 active site 525381002150 putative oxyanion hole; other site 525381002151 catalytic triad [active] 525381002152 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 525381002153 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 525381002154 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 525381002155 PhoU domain; Region: PhoU; pfam01895 525381002156 PhoU domain; Region: PhoU; pfam01895 525381002157 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 525381002158 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 525381002159 putative active site [active] 525381002160 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 525381002161 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 525381002162 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 525381002163 G5 domain; Region: G5; pfam07501 525381002164 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 525381002165 Phosphoglycerate kinase; Region: PGK; pfam00162 525381002166 substrate binding site [chemical binding]; other site 525381002167 hinge regions; other site 525381002168 ADP binding site [chemical binding]; other site 525381002169 catalytic site [active] 525381002170 Predicted membrane protein [Function unknown]; Region: COG4129 525381002171 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 525381002172 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 525381002173 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 525381002174 DNA binding residues [nucleotide binding] 525381002175 putative dimer interface [polypeptide binding]; other site 525381002176 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 525381002177 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 525381002178 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 525381002179 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 525381002180 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 525381002181 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 525381002182 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 525381002183 VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196 525381002184 Int/Topo IB signature motif; other site 525381002185 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 525381002186 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 525381002187 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 525381002188 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 525381002189 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 525381002190 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 525381002191 HsdM N-terminal domain; Region: HsdM_N; pfam12161 525381002192 Methyltransferase domain; Region: Methyltransf_26; pfam13659 525381002193 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 525381002194 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 525381002195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525381002196 ATP binding site [chemical binding]; other site 525381002197 putative Mg++ binding site [ion binding]; other site 525381002198 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 525381002199 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 525381002200 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 525381002201 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 525381002202 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 525381002203 dimer interface [polypeptide binding]; other site 525381002204 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 525381002205 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 525381002206 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 525381002207 nucleotide binding site [chemical binding]; other site 525381002208 NEF interaction site [polypeptide binding]; other site 525381002209 SBD interface [polypeptide binding]; other site 525381002210 chaperone protein DnaJ; Provisional; Region: PRK14276 525381002211 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525381002212 HSP70 interaction site [polypeptide binding]; other site 525381002213 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 525381002214 substrate binding site [polypeptide binding]; other site 525381002215 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 525381002216 Zn binding sites [ion binding]; other site 525381002217 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 525381002218 substrate binding site [polypeptide binding]; other site 525381002219 dimer interface [polypeptide binding]; other site 525381002220 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 525381002221 HIT family signature motif; other site 525381002222 catalytic residue [active] 525381002223 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 525381002224 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525381002225 Walker A/P-loop; other site 525381002226 ATP binding site [chemical binding]; other site 525381002227 Q-loop/lid; other site 525381002228 ABC transporter signature motif; other site 525381002229 Walker B; other site 525381002230 D-loop; other site 525381002231 H-loop/switch region; other site 525381002232 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 525381002233 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 525381002234 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 525381002235 LytTr DNA-binding domain; Region: LytTR; pfam04397 525381002236 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 525381002237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381002238 active site 525381002239 phosphorylation site [posttranslational modification] 525381002240 intermolecular recognition site; other site 525381002241 dimerization interface [polypeptide binding]; other site 525381002242 LytTr DNA-binding domain; Region: LytTR; pfam04397 525381002243 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 525381002244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381002245 ATP binding site [chemical binding]; other site 525381002246 Mg2+ binding site [ion binding]; other site 525381002247 G-X-G motif; other site 525381002248 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381002249 COMC family; Region: ComC; pfam03047 525381002250 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 525381002251 HlyD family secretion protein; Region: HlyD_3; pfam13437 525381002252 potential frameshift: common BLAST hit: gi|194398624|ref|YP_002037195.1| ABC transporter ATP-binding protein BlpA 525381002253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002254 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525381002255 Walker A/P-loop; other site 525381002256 ATP binding site [chemical binding]; other site 525381002257 Q-loop/lid; other site 525381002258 ABC transporter signature motif; other site 525381002259 Walker B; other site 525381002260 D-loop; other site 525381002261 H-loop/switch region; other site 525381002262 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 525381002263 putative active site [active] 525381002264 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 525381002265 CAAX protease self-immunity; Region: Abi; pfam02517 525381002266 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 525381002267 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 525381002268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 525381002269 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 525381002270 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 525381002271 CAAX protease self-immunity; Region: Abi; pfam02517 525381002272 CAAX protease self-immunity; Region: Abi; pfam02517 525381002273 Phosphotransferase enzyme family; Region: APH; pfam01636 525381002274 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 525381002275 substrate binding site [chemical binding]; other site 525381002276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381002277 S-adenosylmethionine binding site [chemical binding]; other site 525381002278 ribosome maturation protein RimP; Reviewed; Region: PRK00092 525381002279 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 525381002280 putative oligomer interface [polypeptide binding]; other site 525381002281 putative RNA binding site [nucleotide binding]; other site 525381002282 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 525381002283 NusA N-terminal domain; Region: NusA_N; pfam08529 525381002284 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 525381002285 RNA binding site [nucleotide binding]; other site 525381002286 homodimer interface [polypeptide binding]; other site 525381002287 NusA-like KH domain; Region: KH_5; pfam13184 525381002288 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 525381002289 G-X-X-G motif; other site 525381002290 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 525381002291 putative RNA binding cleft [nucleotide binding]; other site 525381002292 hypothetical protein; Provisional; Region: PRK07283 525381002293 translation initiation factor IF-2; Region: IF-2; TIGR00487 525381002294 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 525381002295 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 525381002296 G1 box; other site 525381002297 putative GEF interaction site [polypeptide binding]; other site 525381002298 GTP/Mg2+ binding site [chemical binding]; other site 525381002299 Switch I region; other site 525381002300 G2 box; other site 525381002301 G3 box; other site 525381002302 Switch II region; other site 525381002303 G4 box; other site 525381002304 G5 box; other site 525381002305 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 525381002306 Translation-initiation factor 2; Region: IF-2; pfam11987 525381002307 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 525381002308 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 525381002309 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 525381002310 Uncharacterized conserved protein [Function unknown]; Region: COG2461 525381002311 Family of unknown function (DUF438); Region: DUF438; pfam04282 525381002312 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 525381002313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 525381002314 putative active site [active] 525381002315 heme pocket [chemical binding]; other site 525381002316 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 525381002317 hypothetical protein; Provisional; Region: PRK07758 525381002318 Flavin Reductases; Region: FlaRed; cl00801 525381002319 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 525381002320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381002321 Coenzyme A binding pocket [chemical binding]; other site 525381002322 AAA domain; Region: AAA_18; pfam13238 525381002323 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 525381002324 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525381002325 active site 525381002326 HIGH motif; other site 525381002327 nucleotide binding site [chemical binding]; other site 525381002328 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525381002329 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 525381002330 active site 525381002331 KMSKS motif; other site 525381002332 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 525381002333 tRNA binding surface [nucleotide binding]; other site 525381002334 anticodon binding site; other site 525381002335 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 525381002336 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 525381002337 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 525381002338 cofactor binding site; other site 525381002339 AAA domain; Region: AAA_21; pfam13304 525381002340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002341 ABC transporter signature motif; other site 525381002342 Walker B; other site 525381002343 D-loop; other site 525381002344 H-loop/switch region; other site 525381002345 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 525381002346 Fic/DOC family; Region: Fic; pfam02661 525381002347 putative transposase OrfB; Reviewed; Region: PHA02517 525381002348 HTH-like domain; Region: HTH_21; pfam13276 525381002349 Integrase core domain; Region: rve; pfam00665 525381002350 Integrase core domain; Region: rve_2; pfam13333 525381002351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 525381002352 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381002353 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 525381002354 putative active site [active] 525381002355 catalytic site [active] 525381002356 transcriptional antiterminator BglG; Provisional; Region: PRK09772 525381002357 CAT RNA binding domain; Region: CAT_RBD; smart01061 525381002358 PRD domain; Region: PRD; pfam00874 525381002359 PRD domain; Region: PRD; pfam00874 525381002360 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 525381002361 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 525381002362 active site turn [active] 525381002363 phosphorylation site [posttranslational modification] 525381002364 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 525381002365 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 525381002366 HPr interaction site; other site 525381002367 glycerol kinase (GK) interaction site [polypeptide binding]; other site 525381002368 active site 525381002369 phosphorylation site [posttranslational modification] 525381002370 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 525381002371 beta-galactosidase; Region: BGL; TIGR03356 525381002372 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 525381002373 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 525381002374 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 525381002375 dimer interface [polypeptide binding]; other site 525381002376 motif 1; other site 525381002377 active site 525381002378 motif 2; other site 525381002379 motif 3; other site 525381002380 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 525381002381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381002382 Coenzyme A binding pocket [chemical binding]; other site 525381002383 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 525381002384 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 525381002385 putative tRNA-binding site [nucleotide binding]; other site 525381002386 B3/4 domain; Region: B3_4; pfam03483 525381002387 tRNA synthetase B5 domain; Region: B5; smart00874 525381002388 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 525381002389 dimer interface [polypeptide binding]; other site 525381002390 motif 1; other site 525381002391 motif 3; other site 525381002392 motif 2; other site 525381002393 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 525381002394 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 525381002395 putative catalytic site [active] 525381002396 putative metal binding site [ion binding]; other site 525381002397 putative phosphate binding site [ion binding]; other site 525381002398 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 525381002399 Helix-turn-helix domain; Region: HTH_38; pfam13936 525381002400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381002401 non-specific DNA binding site [nucleotide binding]; other site 525381002402 salt bridge; other site 525381002403 sequence-specific DNA binding site [nucleotide binding]; other site 525381002404 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 525381002405 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 525381002406 THF binding site; other site 525381002407 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 525381002408 substrate binding site [chemical binding]; other site 525381002409 THF binding site; other site 525381002410 zinc-binding site [ion binding]; other site 525381002411 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 525381002412 FAD binding site [chemical binding]; other site 525381002413 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 525381002414 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 525381002415 RNase E interface [polypeptide binding]; other site 525381002416 trimer interface [polypeptide binding]; other site 525381002417 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 525381002418 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 525381002419 RNase E interface [polypeptide binding]; other site 525381002420 trimer interface [polypeptide binding]; other site 525381002421 active site 525381002422 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 525381002423 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 525381002424 RNA binding site [nucleotide binding]; other site 525381002425 domain interface; other site 525381002426 serine O-acetyltransferase; Region: cysE; TIGR01172 525381002427 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 525381002428 trimer interface [polypeptide binding]; other site 525381002429 active site 525381002430 substrate binding site [chemical binding]; other site 525381002431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381002432 Coenzyme A binding pocket [chemical binding]; other site 525381002433 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525381002434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381002435 Coenzyme A binding pocket [chemical binding]; other site 525381002436 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 525381002437 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525381002438 active site 525381002439 HIGH motif; other site 525381002440 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525381002441 KMSKS motif; other site 525381002442 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 525381002443 tRNA binding surface [nucleotide binding]; other site 525381002444 anticodon binding site; other site 525381002445 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 525381002446 active site 525381002447 metal binding site [ion binding]; metal-binding site 525381002448 dimerization interface [polypeptide binding]; other site 525381002449 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 525381002450 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 525381002451 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 525381002452 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525381002453 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525381002454 FtsX-like permease family; Region: FtsX; pfam02687 525381002455 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525381002456 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525381002457 Walker A/P-loop; other site 525381002458 ATP binding site [chemical binding]; other site 525381002459 Q-loop/lid; other site 525381002460 ABC transporter signature motif; other site 525381002461 Walker B; other site 525381002462 D-loop; other site 525381002463 H-loop/switch region; other site 525381002464 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525381002465 FtsX-like permease family; Region: FtsX; pfam02687 525381002466 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525381002467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381002468 active site 525381002469 phosphorylation site [posttranslational modification] 525381002470 intermolecular recognition site; other site 525381002471 dimerization interface [polypeptide binding]; other site 525381002472 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525381002473 DNA binding site [nucleotide binding] 525381002474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525381002475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525381002476 dimerization interface [polypeptide binding]; other site 525381002477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525381002478 dimer interface [polypeptide binding]; other site 525381002479 phosphorylation site [posttranslational modification] 525381002480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381002481 ATP binding site [chemical binding]; other site 525381002482 Mg2+ binding site [ion binding]; other site 525381002483 G-X-G motif; other site 525381002484 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 525381002485 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 525381002486 intersubunit interface [polypeptide binding]; other site 525381002487 active site 525381002488 zinc binding site [ion binding]; other site 525381002489 Na+ binding site [ion binding]; other site 525381002490 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 525381002491 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 525381002492 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 525381002493 FAD binding pocket [chemical binding]; other site 525381002494 FAD binding motif [chemical binding]; other site 525381002495 phosphate binding motif [ion binding]; other site 525381002496 beta-alpha-beta structure motif; other site 525381002497 NAD binding pocket [chemical binding]; other site 525381002498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381002499 dimer interface [polypeptide binding]; other site 525381002500 conserved gate region; other site 525381002501 putative PBP binding loops; other site 525381002502 ABC-ATPase subunit interface; other site 525381002503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381002504 dimer interface [polypeptide binding]; other site 525381002505 conserved gate region; other site 525381002506 putative PBP binding loops; other site 525381002507 ABC-ATPase subunit interface; other site 525381002508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381002509 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525381002510 substrate binding pocket [chemical binding]; other site 525381002511 membrane-bound complex binding site; other site 525381002512 hinge residues; other site 525381002513 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525381002514 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525381002515 Walker A/P-loop; other site 525381002516 ATP binding site [chemical binding]; other site 525381002517 Q-loop/lid; other site 525381002518 ABC transporter signature motif; other site 525381002519 Walker B; other site 525381002520 D-loop; other site 525381002521 H-loop/switch region; other site 525381002522 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 525381002523 DHH family; Region: DHH; pfam01368 525381002524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 525381002525 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 525381002526 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525381002527 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 525381002528 Predicted esterase [General function prediction only]; Region: COG0627 525381002529 S-formylglutathione hydrolase; Region: PLN02442 525381002530 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 525381002531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 525381002532 FemAB family; Region: FemAB; pfam02388 525381002533 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 525381002534 active site 525381002535 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 525381002536 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 525381002537 GIY-YIG motif/motif A; other site 525381002538 active site 525381002539 catalytic site [active] 525381002540 putative DNA binding site [nucleotide binding]; other site 525381002541 metal binding site [ion binding]; metal-binding site 525381002542 UvrB/uvrC motif; Region: UVR; pfam02151 525381002543 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 525381002544 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525381002545 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525381002546 active site 525381002547 metal binding site [ion binding]; metal-binding site 525381002548 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525381002549 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525381002550 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381002551 substrate binding pocket [chemical binding]; other site 525381002552 membrane-bound complex binding site; other site 525381002553 hinge residues; other site 525381002554 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 525381002555 dimer interface [polypeptide binding]; other site 525381002556 FMN binding site [chemical binding]; other site 525381002557 dipeptidase PepV; Reviewed; Region: PRK07318 525381002558 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 525381002559 active site 525381002560 metal binding site [ion binding]; metal-binding site 525381002561 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 525381002562 putative uracil binding site [chemical binding]; other site 525381002563 putative active site [active] 525381002564 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525381002565 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 525381002566 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 525381002567 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 525381002568 putative oligomer interface [polypeptide binding]; other site 525381002569 putative active site [active] 525381002570 metal binding site [ion binding]; metal-binding site 525381002571 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 525381002572 nucleotide binding site/active site [active] 525381002573 HIT family signature motif; other site 525381002574 catalytic residue [active] 525381002575 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 525381002576 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 525381002577 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 525381002578 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 525381002579 23S rRNA interface [nucleotide binding]; other site 525381002580 L7/L12 interface [polypeptide binding]; other site 525381002581 putative thiostrepton binding site; other site 525381002582 L25 interface [polypeptide binding]; other site 525381002583 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 525381002584 mRNA/rRNA interface [nucleotide binding]; other site 525381002585 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 525381002586 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 525381002587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002588 Walker A/P-loop; other site 525381002589 ATP binding site [chemical binding]; other site 525381002590 Q-loop/lid; other site 525381002591 ABC transporter signature motif; other site 525381002592 Walker B; other site 525381002593 D-loop; other site 525381002594 H-loop/switch region; other site 525381002595 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 525381002596 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 525381002597 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 525381002598 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 525381002599 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 525381002600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 525381002601 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 525381002602 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 525381002603 putative active site [active] 525381002604 catalytic triad [active] 525381002605 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 525381002606 PA/protease or protease-like domain interface [polypeptide binding]; other site 525381002607 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 525381002608 catalytic residues [active] 525381002609 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 525381002610 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 525381002611 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 525381002612 active site 525381002613 phosphorylation site [posttranslational modification] 525381002614 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 525381002615 active site 525381002616 P-loop; other site 525381002617 phosphorylation site [posttranslational modification] 525381002618 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 525381002619 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 525381002620 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 525381002621 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 525381002622 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 525381002623 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 525381002624 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 525381002625 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 525381002626 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 525381002627 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 525381002628 G5 domain; Region: G5; pfam07501 525381002629 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 525381002630 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 525381002631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 525381002632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 525381002633 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 525381002634 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 525381002635 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 525381002636 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 525381002637 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 525381002638 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 525381002639 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 525381002640 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 525381002641 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 525381002642 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 525381002643 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525381002644 catalytic residues [active] 525381002645 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 525381002646 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 525381002647 SelR domain; Region: SelR; pfam01641 525381002648 Response regulator receiver domain; Region: Response_reg; pfam00072 525381002649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381002650 active site 525381002651 phosphorylation site [posttranslational modification] 525381002652 intermolecular recognition site; other site 525381002653 dimerization interface [polypeptide binding]; other site 525381002654 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 525381002655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525381002656 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 525381002657 Cache domain; Region: Cache_1; pfam02743 525381002658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525381002659 dimerization interface [polypeptide binding]; other site 525381002660 Histidine kinase; Region: His_kinase; pfam06580 525381002661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381002662 ATP binding site [chemical binding]; other site 525381002663 Mg2+ binding site [ion binding]; other site 525381002664 G-X-G motif; other site 525381002665 hypothetical protein; Provisional; Region: PRK13690 525381002666 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 525381002667 Neuroendocrine-specific golgi protein P55 (NESP55); Region: NESP55; pfam06390 525381002668 G5 domain; Region: G5; pfam07501 525381002669 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 525381002670 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 525381002671 aminodeoxychorismate synthase; Provisional; Region: PRK07508 525381002672 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 525381002673 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 525381002674 substrate-cofactor binding pocket; other site 525381002675 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 525381002676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381002677 catalytic residue [active] 525381002678 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525381002679 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525381002680 Excalibur calcium-binding domain; Region: Excalibur; smart00894 525381002681 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 525381002682 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 525381002683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525381002684 nucleotide binding site [chemical binding]; other site 525381002685 thymidylate synthase; Reviewed; Region: thyA; PRK01827 525381002686 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 525381002687 dimerization interface [polypeptide binding]; other site 525381002688 active site 525381002689 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 525381002690 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 525381002691 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 525381002692 GTPases [General function prediction only]; Region: HflX; COG2262 525381002693 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 525381002694 HflX GTPase family; Region: HflX; cd01878 525381002695 G1 box; other site 525381002696 GTP/Mg2+ binding site [chemical binding]; other site 525381002697 Switch I region; other site 525381002698 G2 box; other site 525381002699 G3 box; other site 525381002700 Switch II region; other site 525381002701 G4 box; other site 525381002702 G5 box; other site 525381002703 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 525381002704 ribonuclease Z; Region: RNase_Z; TIGR02651 525381002705 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 525381002706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525381002707 NAD(P) binding site [chemical binding]; other site 525381002708 active site 525381002709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525381002710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525381002711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 525381002712 dimerization interface [polypeptide binding]; other site 525381002713 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 525381002714 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525381002715 active site residue [active] 525381002716 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 525381002717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525381002718 RNA binding surface [nucleotide binding]; other site 525381002719 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 525381002720 active site 525381002721 uracil binding [chemical binding]; other site 525381002722 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 525381002723 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 525381002724 G1 box; other site 525381002725 putative GEF interaction site [polypeptide binding]; other site 525381002726 GTP/Mg2+ binding site [chemical binding]; other site 525381002727 Switch I region; other site 525381002728 G2 box; other site 525381002729 G3 box; other site 525381002730 Switch II region; other site 525381002731 G4 box; other site 525381002732 G5 box; other site 525381002733 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 525381002734 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 525381002735 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 525381002736 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 525381002737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 525381002738 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 525381002739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002740 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 525381002741 Walker A/P-loop; other site 525381002742 ATP binding site [chemical binding]; other site 525381002743 Q-loop/lid; other site 525381002744 ABC transporter signature motif; other site 525381002745 Walker B; other site 525381002746 D-loop; other site 525381002747 H-loop/switch region; other site 525381002748 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 525381002749 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 525381002750 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525381002751 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525381002752 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 525381002753 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 525381002754 homodimer interface [polypeptide binding]; other site 525381002755 active site 525381002756 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 525381002757 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 525381002758 Cell division protein FtsQ; Region: FtsQ; pfam03799 525381002759 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 525381002760 active site 525381002761 dimer interface [polypeptide binding]; other site 525381002762 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381002763 active site 525381002764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002765 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 525381002766 Walker A/P-loop; other site 525381002767 ATP binding site [chemical binding]; other site 525381002768 Q-loop/lid; other site 525381002769 ABC transporter signature motif; other site 525381002770 Walker B; other site 525381002771 D-loop; other site 525381002772 H-loop/switch region; other site 525381002773 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381002774 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 525381002775 substrate binding pocket [chemical binding]; other site 525381002776 membrane-bound complex binding site; other site 525381002777 hinge residues; other site 525381002778 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 525381002779 potential frameshift: common BLAST hit: gi|116515352|ref|YP_816112.1| amino acid ABC transporter, ATP-binding protein 525381002780 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525381002781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002782 Q-loop/lid; other site 525381002783 ABC transporter signature motif; other site 525381002784 Walker B; other site 525381002785 D-loop; other site 525381002786 H-loop/switch region; other site 525381002787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525381002789 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381002790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381002791 conserved gate region; other site 525381002792 ABC-ATPase subunit interface; other site 525381002793 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525381002794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381002795 dimer interface [polypeptide binding]; other site 525381002796 conserved gate region; other site 525381002797 putative PBP binding loops; other site 525381002798 ABC-ATPase subunit interface; other site 525381002799 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 525381002800 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 525381002801 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 525381002802 dimer interface [polypeptide binding]; other site 525381002803 putative anticodon binding site; other site 525381002804 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 525381002805 motif 1; other site 525381002806 active site 525381002807 motif 2; other site 525381002808 motif 3; other site 525381002809 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381002810 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 525381002811 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 525381002812 teramer interface [polypeptide binding]; other site 525381002813 active site 525381002814 FMN binding site [chemical binding]; other site 525381002815 catalytic residues [active] 525381002816 Putative transcription activator [Transcription]; Region: TenA; COG0819 525381002817 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 525381002818 substrate binding site [chemical binding]; other site 525381002819 multimerization interface [polypeptide binding]; other site 525381002820 ATP binding site [chemical binding]; other site 525381002821 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 525381002822 thiamine phosphate binding site [chemical binding]; other site 525381002823 active site 525381002824 pyrophosphate binding site [ion binding]; other site 525381002825 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 525381002826 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525381002827 Walker A/P-loop; other site 525381002828 ATP binding site [chemical binding]; other site 525381002829 ABC transporter; Region: ABC_tran; pfam00005 525381002830 Q-loop/lid; other site 525381002831 ABC transporter signature motif; other site 525381002832 Walker B; other site 525381002833 D-loop; other site 525381002834 H-loop/switch region; other site 525381002835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002836 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 525381002837 Walker A/P-loop; other site 525381002838 ATP binding site [chemical binding]; other site 525381002839 Q-loop/lid; other site 525381002840 ABC transporter signature motif; other site 525381002841 Walker B; other site 525381002842 D-loop; other site 525381002843 H-loop/switch region; other site 525381002844 Putative transcription activator [Transcription]; Region: TenA; COG0819 525381002845 Predicted membrane protein [Function unknown]; Region: COG4732 525381002846 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 525381002847 substrate binding site [chemical binding]; other site 525381002848 multimerization interface [polypeptide binding]; other site 525381002849 ATP binding site [chemical binding]; other site 525381002850 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 525381002851 thiamine phosphate binding site [chemical binding]; other site 525381002852 active site 525381002853 pyrophosphate binding site [ion binding]; other site 525381002854 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 525381002855 dimer interface [polypeptide binding]; other site 525381002856 substrate binding site [chemical binding]; other site 525381002857 ATP binding site [chemical binding]; other site 525381002858 Predicted transcriptional regulator [Transcription]; Region: COG3682 525381002859 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 525381002860 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 525381002861 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 525381002862 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 525381002863 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525381002864 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 525381002865 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 525381002866 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 525381002867 PYR/PP interface [polypeptide binding]; other site 525381002868 dimer interface [polypeptide binding]; other site 525381002869 tetramer interface [polypeptide binding]; other site 525381002870 TPP binding site [chemical binding]; other site 525381002871 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 525381002872 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 525381002873 TPP-binding site [chemical binding]; other site 525381002874 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 525381002875 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 525381002876 active site 525381002877 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381002878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381002879 Winged helix-turn helix; Region: HTH_33; pfam13592 525381002880 Homeodomain-like domain; Region: HTH_23; pfam13384 525381002881 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 525381002882 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 525381002883 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 525381002884 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 525381002885 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 525381002886 Na2 binding site [ion binding]; other site 525381002887 putative substrate binding site 1 [chemical binding]; other site 525381002888 Na binding site 1 [ion binding]; other site 525381002889 putative substrate binding site 2 [chemical binding]; other site 525381002890 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 525381002891 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 525381002892 dimer interface [polypeptide binding]; other site 525381002893 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 525381002894 potential frameshift: common BLAST hit: gi|194397382|ref|YP_002037386.1| MutT/nudix family protein 525381002895 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 525381002896 putative active site [active] 525381002897 nucleotide binding site [chemical binding]; other site 525381002898 nudix motif; other site 525381002899 putative metal binding site [ion binding]; other site 525381002900 HI0933-like protein; Region: HI0933_like; pfam03486 525381002901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 525381002902 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 525381002903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525381002904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525381002905 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 525381002906 catalytic motif [active] 525381002907 Zn binding site [ion binding]; other site 525381002908 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381002909 active site 525381002910 Clp protease; Region: CLP_protease; pfam00574 525381002911 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 525381002912 oligomer interface [polypeptide binding]; other site 525381002913 active site residues [active] 525381002914 hypothetical protein; Provisional; Region: PRK02302 525381002915 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525381002916 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 525381002917 putative ligand binding site [chemical binding]; other site 525381002918 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525381002919 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525381002920 TM-ABC transporter signature motif; other site 525381002921 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525381002922 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525381002923 TM-ABC transporter signature motif; other site 525381002924 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525381002925 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525381002926 Walker A/P-loop; other site 525381002927 ATP binding site [chemical binding]; other site 525381002928 Q-loop/lid; other site 525381002929 ABC transporter signature motif; other site 525381002930 Walker B; other site 525381002931 D-loop; other site 525381002932 H-loop/switch region; other site 525381002933 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525381002934 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525381002935 Walker A/P-loop; other site 525381002936 ATP binding site [chemical binding]; other site 525381002937 Q-loop/lid; other site 525381002938 ABC transporter signature motif; other site 525381002939 Walker B; other site 525381002940 D-loop; other site 525381002941 H-loop/switch region; other site 525381002942 FOG: CBS domain [General function prediction only]; Region: COG0517 525381002943 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 525381002944 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 525381002945 PCRF domain; Region: PCRF; pfam03462 525381002946 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 525381002947 RF-1 domain; Region: RF-1; pfam00472 525381002948 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 525381002949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381002950 Walker A/P-loop; other site 525381002951 ATP binding site [chemical binding]; other site 525381002952 Q-loop/lid; other site 525381002953 ABC transporter signature motif; other site 525381002954 Walker B; other site 525381002955 D-loop; other site 525381002956 H-loop/switch region; other site 525381002957 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 525381002958 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 525381002959 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 525381002960 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 525381002961 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 525381002962 active site turn [active] 525381002963 phosphorylation site [posttranslational modification] 525381002964 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 525381002965 HPr interaction site; other site 525381002966 glycerol kinase (GK) interaction site [polypeptide binding]; other site 525381002967 active site 525381002968 phosphorylation site [posttranslational modification] 525381002969 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 525381002970 putative catalytic site [active] 525381002971 putative metal binding site [ion binding]; other site 525381002972 putative phosphate binding site [ion binding]; other site 525381002973 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 525381002974 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525381002975 ATP binding site [chemical binding]; other site 525381002976 Mg++ binding site [ion binding]; other site 525381002977 motif III; other site 525381002978 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525381002979 nucleotide binding region [chemical binding]; other site 525381002980 ATP-binding site [chemical binding]; other site 525381002981 S-adenosylmethionine synthetase; Validated; Region: PRK05250 525381002982 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 525381002983 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 525381002984 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 525381002985 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 525381002986 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 525381002987 active site 525381002988 FMN binding site [chemical binding]; other site 525381002989 substrate binding site [chemical binding]; other site 525381002990 catalytic residues [active] 525381002991 homodimer interface [polypeptide binding]; other site 525381002992 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 525381002993 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 525381002994 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 525381002995 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 525381002996 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 525381002997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 525381002998 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 525381002999 VanZ like family; Region: VanZ; pfam04892 525381003000 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525381003001 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381003002 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381003003 ABC transporter; Region: ABC_tran_2; pfam12848 525381003004 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381003005 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 525381003006 active site 525381003007 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 525381003008 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 525381003009 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 525381003010 KH domain; Region: KH_4; pfam13083 525381003011 G-X-X-G motif; other site 525381003012 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381003013 Homeodomain-like domain; Region: HTH_23; pfam13384 525381003014 Winged helix-turn helix; Region: HTH_29; pfam13551 525381003015 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381003016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381003017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 525381003018 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525381003019 ATP binding site [chemical binding]; other site 525381003020 putative Mg++ binding site [ion binding]; other site 525381003021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525381003022 nucleotide binding region [chemical binding]; other site 525381003023 ATP-binding site [chemical binding]; other site 525381003024 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 525381003025 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 525381003026 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 525381003027 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 525381003028 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 525381003029 NodB motif; other site 525381003030 active site 525381003031 catalytic site [active] 525381003032 Zn binding site [ion binding]; other site 525381003033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 525381003034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 525381003035 active site 525381003036 catalytic tetrad [active] 525381003037 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 525381003038 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 525381003039 dimer interface [polypeptide binding]; other site 525381003040 motif 1; other site 525381003041 active site 525381003042 motif 2; other site 525381003043 motif 3; other site 525381003044 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 525381003045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 525381003046 DALR anticodon binding domain; Region: DALR_1; pfam05746 525381003047 hypothetical protein; Provisional; Region: PRK02539 525381003048 Predicted flavoprotein [General function prediction only]; Region: COG0431 525381003049 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525381003050 PAS domain; Region: PAS_10; pfam13596 525381003051 Predicted flavoprotein [General function prediction only]; Region: COG0431 525381003052 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525381003053 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 525381003054 ApbE family; Region: ApbE; pfam02424 525381003055 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 525381003056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525381003057 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525381003058 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 525381003059 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 525381003060 active site 525381003061 multimer interface [polypeptide binding]; other site 525381003062 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 525381003063 predicted active site [active] 525381003064 catalytic triad [active] 525381003065 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 525381003066 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 525381003067 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 525381003068 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 525381003069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 525381003070 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 525381003071 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 525381003072 DNA binding site [nucleotide binding] 525381003073 active site 525381003074 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 525381003075 putative ArsC-like catalytic residues; other site 525381003076 putative TRX-like catalytic residues [active] 525381003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525381003078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381003079 ABC-ATPase subunit interface; other site 525381003080 putative PBP binding loops; other site 525381003081 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525381003082 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525381003083 Walker A/P-loop; other site 525381003084 ATP binding site [chemical binding]; other site 525381003085 Q-loop/lid; other site 525381003086 ABC transporter signature motif; other site 525381003087 Walker B; other site 525381003088 D-loop; other site 525381003089 H-loop/switch region; other site 525381003090 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 525381003091 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 525381003092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525381003093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525381003094 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 525381003095 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 525381003096 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 525381003097 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 525381003098 active site 525381003099 catalytic residues [active] 525381003100 metal binding site [ion binding]; metal-binding site 525381003101 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 525381003102 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 525381003103 putative active site [active] 525381003104 putative metal binding site [ion binding]; other site 525381003105 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 525381003106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003107 active site 525381003108 motif I; other site 525381003109 motif II; other site 525381003110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003111 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 525381003112 active site 525381003113 catalytic triad [active] 525381003114 oxyanion hole [active] 525381003115 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 525381003116 Beta-lactamase; Region: Beta-lactamase; pfam00144 525381003117 EamA-like transporter family; Region: EamA; pfam00892 525381003118 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 525381003119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525381003120 DNA-binding site [nucleotide binding]; DNA binding site 525381003121 UTRA domain; Region: UTRA; pfam07702 525381003122 GMP synthase; Reviewed; Region: guaA; PRK00074 525381003123 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 525381003124 AMP/PPi binding site [chemical binding]; other site 525381003125 candidate oxyanion hole; other site 525381003126 catalytic triad [active] 525381003127 potential glutamine specificity residues [chemical binding]; other site 525381003128 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 525381003129 ATP Binding subdomain [chemical binding]; other site 525381003130 Dimerization subdomain; other site 525381003131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381003132 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381003133 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381003134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381003135 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525381003136 Helix-turn-helix domain; Region: HTH_18; pfam12833 525381003137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525381003138 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525381003139 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381003140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381003141 Walker A/P-loop; other site 525381003142 ATP binding site [chemical binding]; other site 525381003143 Q-loop/lid; other site 525381003144 ABC transporter signature motif; other site 525381003145 Walker B; other site 525381003146 D-loop; other site 525381003147 H-loop/switch region; other site 525381003148 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525381003149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381003150 Walker A/P-loop; other site 525381003151 ATP binding site [chemical binding]; other site 525381003152 Q-loop/lid; other site 525381003153 ABC transporter signature motif; other site 525381003154 Walker B; other site 525381003155 D-loop; other site 525381003156 H-loop/switch region; other site 525381003157 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 525381003158 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 525381003159 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525381003160 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525381003161 Walker A/P-loop; other site 525381003162 ATP binding site [chemical binding]; other site 525381003163 Q-loop/lid; other site 525381003164 ABC transporter signature motif; other site 525381003165 Walker B; other site 525381003166 D-loop; other site 525381003167 H-loop/switch region; other site 525381003168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381003169 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 525381003170 Walker A/P-loop; other site 525381003171 ATP binding site [chemical binding]; other site 525381003172 Q-loop/lid; other site 525381003173 ABC transporter signature motif; other site 525381003174 Walker B; other site 525381003175 D-loop; other site 525381003176 H-loop/switch region; other site 525381003177 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 525381003178 potential frameshift: common BLAST hit: gi|289166941|ref|YP_003445208.1| transposase, ISSmi4 525381003179 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 525381003180 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 525381003181 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 525381003182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381003183 S-adenosylmethionine binding site [chemical binding]; other site 525381003184 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 525381003185 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 525381003186 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 525381003187 Peptidase family U32; Region: Peptidase_U32; pfam01136 525381003188 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 525381003189 Peptidase family U32; Region: Peptidase_U32; pfam01136 525381003190 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 525381003191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381003192 ABC transporter; Region: ABC_tran; pfam00005 525381003193 Q-loop/lid; other site 525381003194 ABC transporter signature motif; other site 525381003195 Walker B; other site 525381003196 D-loop; other site 525381003197 H-loop/switch region; other site 525381003198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381003199 non-specific DNA binding site [nucleotide binding]; other site 525381003200 salt bridge; other site 525381003201 sequence-specific DNA binding site [nucleotide binding]; other site 525381003202 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 525381003203 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 525381003204 active site 525381003205 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 525381003206 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 525381003207 homodimer interface [polypeptide binding]; other site 525381003208 NAD binding pocket [chemical binding]; other site 525381003209 ATP binding pocket [chemical binding]; other site 525381003210 Mg binding site [ion binding]; other site 525381003211 active-site loop [active] 525381003212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525381003213 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525381003214 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381003215 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 525381003216 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381003217 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381003218 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 525381003219 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 525381003220 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 525381003221 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 525381003222 active site 525381003223 trimer interface [polypeptide binding]; other site 525381003224 allosteric site; other site 525381003225 active site lid [active] 525381003226 hexamer (dimer of trimers) interface [polypeptide binding]; other site 525381003227 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 525381003228 HPr kinase/phosphorylase; Provisional; Region: PRK05428 525381003229 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 525381003230 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 525381003231 Hpr binding site; other site 525381003232 active site 525381003233 homohexamer subunit interaction site [polypeptide binding]; other site 525381003234 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 525381003235 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 525381003236 YtxH-like protein; Region: YtxH; pfam12732 525381003237 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 525381003238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525381003239 FeS/SAM binding site; other site 525381003240 HemN C-terminal domain; Region: HemN_C; pfam06969 525381003241 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 525381003242 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 525381003243 active site 525381003244 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 525381003245 active site 525381003246 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 525381003247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003248 active site 525381003249 motif I; other site 525381003250 motif II; other site 525381003251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003252 Predicted membrane protein [Function unknown]; Region: COG4478 525381003253 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 525381003254 ArsC family; Region: ArsC; pfam03960 525381003255 putative catalytic residues [active] 525381003256 thiol/disulfide switch; other site 525381003257 hypothetical protein; Provisional; Region: PRK04387 525381003258 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 525381003259 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 525381003260 active site 525381003261 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 525381003262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381003263 S-adenosylmethionine binding site [chemical binding]; other site 525381003264 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 525381003265 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 525381003266 phosphate binding protein; Region: ptsS_2; TIGR02136 525381003267 sulfate transport protein; Provisional; Region: cysT; CHL00187 525381003268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381003269 dimer interface [polypeptide binding]; other site 525381003270 conserved gate region; other site 525381003271 putative PBP binding loops; other site 525381003272 ABC-ATPase subunit interface; other site 525381003273 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 525381003274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381003275 dimer interface [polypeptide binding]; other site 525381003276 conserved gate region; other site 525381003277 putative PBP binding loops; other site 525381003278 ABC-ATPase subunit interface; other site 525381003279 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 525381003280 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 525381003281 Walker A/P-loop; other site 525381003282 ATP binding site [chemical binding]; other site 525381003283 Q-loop/lid; other site 525381003284 ABC transporter signature motif; other site 525381003285 Walker B; other site 525381003286 D-loop; other site 525381003287 H-loop/switch region; other site 525381003288 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 525381003289 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 525381003290 Walker A/P-loop; other site 525381003291 ATP binding site [chemical binding]; other site 525381003292 Q-loop/lid; other site 525381003293 ABC transporter signature motif; other site 525381003294 Walker B; other site 525381003295 D-loop; other site 525381003296 H-loop/switch region; other site 525381003297 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 525381003298 PhoU domain; Region: PhoU; pfam01895 525381003299 PhoU domain; Region: PhoU; pfam01895 525381003300 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381003301 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525381003302 substrate binding pocket [chemical binding]; other site 525381003303 membrane-bound complex binding site; other site 525381003304 hinge residues; other site 525381003305 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 525381003306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525381003307 DNA-binding site [nucleotide binding]; DNA binding site 525381003308 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525381003309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381003310 homodimer interface [polypeptide binding]; other site 525381003311 catalytic residue [active] 525381003312 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 525381003313 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 525381003314 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 525381003315 FAD binding domain; Region: FAD_binding_4; pfam01565 525381003316 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 525381003317 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525381003318 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 525381003319 Walker A/P-loop; other site 525381003320 ATP binding site [chemical binding]; other site 525381003321 Q-loop/lid; other site 525381003322 ABC transporter signature motif; other site 525381003323 Walker B; other site 525381003324 D-loop; other site 525381003325 H-loop/switch region; other site 525381003326 TOBE domain; Region: TOBE_2; pfam08402 525381003327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381003328 dimer interface [polypeptide binding]; other site 525381003329 conserved gate region; other site 525381003330 putative PBP binding loops; other site 525381003331 ABC-ATPase subunit interface; other site 525381003332 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 525381003333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381003334 dimer interface [polypeptide binding]; other site 525381003335 conserved gate region; other site 525381003336 putative PBP binding loops; other site 525381003337 ABC-ATPase subunit interface; other site 525381003338 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 525381003339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525381003340 Uncharacterized conserved protein [Function unknown]; Region: COG4894 525381003341 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 525381003342 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 525381003343 motif 1; other site 525381003344 active site 525381003345 motif 2; other site 525381003346 motif 3; other site 525381003347 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 525381003348 DHHA1 domain; Region: DHHA1; pfam02272 525381003349 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 525381003350 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 525381003351 active site 525381003352 Na/Ca binding site [ion binding]; other site 525381003353 catalytic site [active] 525381003354 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 525381003355 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 525381003356 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525381003357 Walker A/P-loop; other site 525381003358 ATP binding site [chemical binding]; other site 525381003359 Q-loop/lid; other site 525381003360 ABC transporter signature motif; other site 525381003361 Walker B; other site 525381003362 D-loop; other site 525381003363 H-loop/switch region; other site 525381003364 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 525381003365 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 525381003366 putative RNA binding site [nucleotide binding]; other site 525381003367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381003368 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 525381003369 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 525381003370 active site 525381003371 catalytic residue [active] 525381003372 dimer interface [polypeptide binding]; other site 525381003373 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 525381003374 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 525381003375 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 525381003376 shikimate binding site; other site 525381003377 NAD(P) binding site [chemical binding]; other site 525381003378 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 525381003379 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 525381003380 active site 525381003381 dimer interface [polypeptide binding]; other site 525381003382 metal binding site [ion binding]; metal-binding site 525381003383 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 525381003384 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 525381003385 Tetramer interface [polypeptide binding]; other site 525381003386 active site 525381003387 FMN-binding site [chemical binding]; other site 525381003388 prephenate dehydrogenase; Validated; Region: PRK06545 525381003389 prephenate dehydrogenase; Validated; Region: PRK08507 525381003390 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 525381003391 hypothetical protein; Provisional; Region: PRK13676 525381003392 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 525381003393 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 525381003394 hinge; other site 525381003395 active site 525381003396 shikimate kinase; Reviewed; Region: aroK; PRK00131 525381003397 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 525381003398 ADP binding site [chemical binding]; other site 525381003399 magnesium binding site [ion binding]; other site 525381003400 putative shikimate binding site; other site 525381003401 prephenate dehydratase; Provisional; Region: PRK11898 525381003402 Prephenate dehydratase; Region: PDT; pfam00800 525381003403 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 525381003404 putative L-Phe binding site [chemical binding]; other site 525381003405 Transcriptional regulator [Transcription]; Region: LytR; COG1316 525381003406 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 525381003407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525381003408 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 525381003409 putative ADP-binding pocket [chemical binding]; other site 525381003410 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525381003411 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525381003412 active site 525381003413 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 525381003414 adaptor protein; Provisional; Region: PRK02315 525381003415 homoserine dehydrogenase; Provisional; Region: PRK06349 525381003416 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 525381003417 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 525381003418 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 525381003419 homoserine kinase; Provisional; Region: PRK01212 525381003420 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 525381003421 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 525381003422 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 525381003423 SelR domain; Region: SelR; pfam01641 525381003424 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525381003425 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381003426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381003427 Walker A/P-loop; other site 525381003428 ATP binding site [chemical binding]; other site 525381003429 Q-loop/lid; other site 525381003430 ABC transporter signature motif; other site 525381003431 Walker B; other site 525381003432 D-loop; other site 525381003433 H-loop/switch region; other site 525381003434 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525381003435 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381003436 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 525381003437 Walker A/P-loop; other site 525381003438 ATP binding site [chemical binding]; other site 525381003439 Q-loop/lid; other site 525381003440 ABC transporter signature motif; other site 525381003441 Walker B; other site 525381003442 D-loop; other site 525381003443 H-loop/switch region; other site 525381003444 chlorohydrolase; Validated; Region: PRK06687 525381003445 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 525381003446 active site 525381003447 putative substrate binding pocket [chemical binding]; other site 525381003448 ribosomal protein L10 leader; HMPREF0837_nc10016 525381003449 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 525381003450 23S rRNA interface [nucleotide binding]; other site 525381003451 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 525381003452 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 525381003453 core dimer interface [polypeptide binding]; other site 525381003454 L10 interface [polypeptide binding]; other site 525381003455 L11 interface [polypeptide binding]; other site 525381003456 putative EF-Tu interaction site [polypeptide binding]; other site 525381003457 putative EF-G interaction site [polypeptide binding]; other site 525381003458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381003459 Walker A motif; other site 525381003460 ATP binding site [chemical binding]; other site 525381003461 Walker B motif; other site 525381003462 glutamate dehydrogenase; Provisional; Region: PRK09414 525381003463 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 525381003464 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 525381003465 NAD(P) binding site [chemical binding]; other site 525381003466 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381003467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381003468 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 525381003469 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 525381003470 DHH family; Region: DHH; pfam01368 525381003471 flavodoxin; Validated; Region: PRK07308 525381003472 hypothetical protein; Provisional; Region: PRK07248 525381003473 camphor resistance protein CrcB; Provisional; Region: PRK14221 525381003474 camphor resistance protein CrcB; Provisional; Region: PRK14229 525381003475 ribosomal protein L19 leader; HMPREF0837_nc10017 525381003476 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 525381003477 SAP domain; Region: SAP; pfam02037 525381003478 sugar phosphate phosphatase; Provisional; Region: PRK10513 525381003479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003480 active site 525381003481 motif I; other site 525381003482 motif II; other site 525381003483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003484 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 525381003485 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525381003486 Zn2+ binding site [ion binding]; other site 525381003487 Mg2+ binding site [ion binding]; other site 525381003488 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 525381003489 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 525381003490 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 525381003491 signal recognition particle protein; Provisional; Region: PRK10867 525381003492 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 525381003493 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 525381003494 P loop; other site 525381003495 GTP binding site [chemical binding]; other site 525381003496 Signal peptide binding domain; Region: SRP_SPB; pfam02978 525381003497 uracil transporter; Provisional; Region: PRK10720 525381003498 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 525381003499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381003500 S-adenosylmethionine binding site [chemical binding]; other site 525381003501 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 525381003502 heat shock protein HtpX; Provisional; Region: PRK04897 525381003503 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525381003504 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381003505 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381003506 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 525381003507 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 525381003508 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525381003509 minor groove reading motif; other site 525381003510 helix-hairpin-helix signature motif; other site 525381003511 substrate binding pocket [chemical binding]; other site 525381003512 active site 525381003513 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 525381003514 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381003515 active site 525381003516 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 525381003517 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525381003518 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 525381003519 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 525381003520 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 525381003521 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 525381003522 catalytic site [active] 525381003523 subunit interface [polypeptide binding]; other site 525381003524 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 525381003525 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525381003526 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 525381003527 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 525381003528 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525381003529 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525381003530 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 525381003531 IMP binding site; other site 525381003532 dimer interface [polypeptide binding]; other site 525381003533 interdomain contacts; other site 525381003534 partial ornithine binding site; other site 525381003535 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 525381003536 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 525381003537 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 525381003538 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 525381003539 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 525381003540 substrate binding site; other site 525381003541 dimer interface; other site 525381003542 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 525381003543 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 525381003544 putative NAD(P) binding site [chemical binding]; other site 525381003545 putative catalytic Zn binding site [ion binding]; other site 525381003546 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 525381003547 Phosphotransferase enzyme family; Region: APH; pfam01636 525381003548 active site 525381003549 substrate binding site [chemical binding]; other site 525381003550 ATP binding site [chemical binding]; other site 525381003551 dimer interface [polypeptide binding]; other site 525381003552 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 525381003553 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 525381003554 active site 525381003555 metal-binding site 525381003556 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 525381003557 DNA protecting protein DprA; Region: dprA; TIGR00732 525381003558 Predicted membrane protein [Function unknown]; Region: COG1808 525381003559 DNA topoisomerase I; Validated; Region: PRK05582 525381003560 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 525381003561 active site 525381003562 interdomain interaction site; other site 525381003563 putative metal-binding site [ion binding]; other site 525381003564 nucleotide binding site [chemical binding]; other site 525381003565 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 525381003566 domain I; other site 525381003567 DNA binding groove [nucleotide binding] 525381003568 phosphate binding site [ion binding]; other site 525381003569 domain II; other site 525381003570 domain III; other site 525381003571 nucleotide binding site [chemical binding]; other site 525381003572 catalytic site [active] 525381003573 domain IV; other site 525381003574 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525381003575 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525381003576 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 525381003577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 525381003578 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 525381003579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 525381003580 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 525381003581 metal binding site [ion binding]; metal-binding site 525381003582 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 525381003583 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 525381003584 tartrate dehydrogenase; Region: TTC; TIGR02089 525381003585 Predicted membrane protein [Function unknown]; Region: COG3326 525381003586 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 525381003587 substrate binding site [chemical binding]; other site 525381003588 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 525381003589 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 525381003590 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 525381003591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381003592 Walker A motif; other site 525381003593 ATP binding site [chemical binding]; other site 525381003594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 525381003595 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 525381003596 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 525381003597 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 525381003598 active site 525381003599 ribonuclease III; Reviewed; Region: rnc; PRK00102 525381003600 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 525381003601 dimerization interface [polypeptide binding]; other site 525381003602 active site 525381003603 metal binding site [ion binding]; metal-binding site 525381003604 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 525381003605 dsRNA binding site [nucleotide binding]; other site 525381003606 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 525381003607 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 525381003608 Walker A/P-loop; other site 525381003609 ATP binding site [chemical binding]; other site 525381003610 Q-loop/lid; other site 525381003611 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 525381003612 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 525381003613 ABC transporter signature motif; other site 525381003614 Walker B; other site 525381003615 D-loop; other site 525381003616 H-loop/switch region; other site 525381003617 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 525381003618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003619 active site 525381003620 motif I; other site 525381003621 motif II; other site 525381003622 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 525381003623 sugar phosphate phosphatase; Provisional; Region: PRK10513 525381003624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003625 motif II; other site 525381003626 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 525381003627 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 525381003628 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 525381003629 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 525381003630 P loop; other site 525381003631 GTP binding site [chemical binding]; other site 525381003632 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 525381003633 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 525381003634 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 525381003635 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525381003636 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525381003637 Walker A/P-loop; other site 525381003638 ATP binding site [chemical binding]; other site 525381003639 Q-loop/lid; other site 525381003640 ABC transporter signature motif; other site 525381003641 Walker B; other site 525381003642 D-loop; other site 525381003643 H-loop/switch region; other site 525381003644 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381003645 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525381003646 substrate binding pocket [chemical binding]; other site 525381003647 membrane-bound complex binding site; other site 525381003648 hinge residues; other site 525381003649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381003650 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525381003651 substrate binding pocket [chemical binding]; other site 525381003652 membrane-bound complex binding site; other site 525381003653 hinge residues; other site 525381003654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381003655 dimer interface [polypeptide binding]; other site 525381003656 conserved gate region; other site 525381003657 putative PBP binding loops; other site 525381003658 ABC-ATPase subunit interface; other site 525381003659 CAAX protease self-immunity; Region: Abi; pfam02517 525381003660 excinuclease ABC subunit B; Provisional; Region: PRK05298 525381003661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525381003662 ATP binding site [chemical binding]; other site 525381003663 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525381003664 nucleotide binding region [chemical binding]; other site 525381003665 ATP-binding site [chemical binding]; other site 525381003666 Ultra-violet resistance protein B; Region: UvrB; pfam12344 525381003667 UvrB/uvrC motif; Region: UVR; pfam02151 525381003668 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 525381003669 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 525381003670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381003671 Coenzyme A binding pocket [chemical binding]; other site 525381003672 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 525381003673 putative active site [active] 525381003674 nucleotide binding site [chemical binding]; other site 525381003675 nudix motif; other site 525381003676 putative metal binding site [ion binding]; other site 525381003677 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 525381003678 HTH domain; Region: HTH_11; pfam08279 525381003679 3H domain; Region: 3H; pfam02829 525381003680 Predicted membrane protein [Function unknown]; Region: COG4684 525381003681 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 525381003682 Flavoprotein; Region: Flavoprotein; pfam02441 525381003683 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 525381003684 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 525381003685 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 525381003686 Potassium binding sites [ion binding]; other site 525381003687 Cesium cation binding sites [ion binding]; other site 525381003688 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 525381003689 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525381003690 minor groove reading motif; other site 525381003691 helix-hairpin-helix signature motif; other site 525381003692 substrate binding pocket [chemical binding]; other site 525381003693 active site 525381003694 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 525381003695 DNA binding and oxoG recognition site [nucleotide binding] 525381003696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525381003697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381003698 active site 525381003699 phosphorylation site [posttranslational modification] 525381003700 intermolecular recognition site; other site 525381003701 dimerization interface [polypeptide binding]; other site 525381003702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525381003703 DNA binding site [nucleotide binding] 525381003704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 525381003705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525381003706 putative active site [active] 525381003707 heme pocket [chemical binding]; other site 525381003708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525381003709 dimer interface [polypeptide binding]; other site 525381003710 phosphorylation site [posttranslational modification] 525381003711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381003712 ATP binding site [chemical binding]; other site 525381003713 Mg2+ binding site [ion binding]; other site 525381003714 G-X-G motif; other site 525381003715 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 525381003716 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 525381003717 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 525381003718 Ion channel; Region: Ion_trans_2; pfam07885 525381003719 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381003720 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 525381003721 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 525381003722 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525381003723 NAD binding site [chemical binding]; other site 525381003724 dimer interface [polypeptide binding]; other site 525381003725 substrate binding site [chemical binding]; other site 525381003726 DNA gyrase subunit A; Validated; Region: PRK05560 525381003727 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 525381003728 CAP-like domain; other site 525381003729 active site 525381003730 primary dimer interface [polypeptide binding]; other site 525381003731 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525381003732 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525381003733 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525381003734 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525381003735 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525381003736 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525381003737 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 525381003738 active site 525381003739 catalytic site [active] 525381003740 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 525381003741 Dppa2/4 conserved region; Region: DCR; pfam14047 525381003742 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 525381003743 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525381003744 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525381003745 catalytic residue [active] 525381003746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 525381003747 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 525381003748 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 525381003749 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 525381003750 RNA binding site [nucleotide binding]; other site 525381003751 active site 525381003752 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 525381003753 Enterocin A Immunity; Region: EntA_Immun; pfam08951 525381003754 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 525381003755 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 525381003756 Sugar specificity; other site 525381003757 Pyrimidine base specificity; other site 525381003758 ATP-binding site [chemical binding]; other site 525381003759 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 525381003760 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 525381003761 generic binding surface II; other site 525381003762 generic binding surface I; other site 525381003763 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 525381003764 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 525381003765 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 525381003766 substrate binding pocket [chemical binding]; other site 525381003767 chain length determination region; other site 525381003768 substrate-Mg2+ binding site; other site 525381003769 catalytic residues [active] 525381003770 aspartate-rich region 1; other site 525381003771 active site lid residues [active] 525381003772 aspartate-rich region 2; other site 525381003773 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 525381003774 S4 RNA-binding domain; Region: S4; smart00363 525381003775 RNA binding surface [nucleotide binding]; other site 525381003776 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 525381003777 Arginine repressor [Transcription]; Region: ArgR; COG1438 525381003778 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 525381003779 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 525381003780 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 525381003781 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 525381003782 Walker A/P-loop; other site 525381003783 ATP binding site [chemical binding]; other site 525381003784 Q-loop/lid; other site 525381003785 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 525381003786 ABC transporter signature motif; other site 525381003787 Walker B; other site 525381003788 D-loop; other site 525381003789 H-loop/switch region; other site 525381003790 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 525381003791 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525381003792 active site 525381003793 metal binding site [ion binding]; metal-binding site 525381003794 GTP-binding protein LepA; Provisional; Region: PRK05433 525381003795 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 525381003796 G1 box; other site 525381003797 putative GEF interaction site [polypeptide binding]; other site 525381003798 GTP/Mg2+ binding site [chemical binding]; other site 525381003799 Switch I region; other site 525381003800 G2 box; other site 525381003801 G3 box; other site 525381003802 Switch II region; other site 525381003803 G4 box; other site 525381003804 G5 box; other site 525381003805 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 525381003806 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 525381003807 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 525381003808 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 525381003809 active site 525381003810 phosphorylation site [posttranslational modification] 525381003811 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 525381003812 active site 525381003813 P-loop; other site 525381003814 phosphorylation site [posttranslational modification] 525381003815 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 525381003816 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 525381003817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 525381003818 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 525381003819 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 525381003820 active site 525381003821 catalytic residues [active] 525381003822 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 525381003823 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 525381003824 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 525381003825 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 525381003826 putative substrate binding site [chemical binding]; other site 525381003827 putative ATP binding site [chemical binding]; other site 525381003828 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 525381003829 transcriptional antiterminator BglG; Provisional; Region: PRK09772 525381003830 CAT RNA binding domain; Region: CAT_RBD; smart01061 525381003831 PRD domain; Region: PRD; pfam00874 525381003832 PRD domain; Region: PRD; pfam00874 525381003833 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 525381003834 methionine cluster; other site 525381003835 active site 525381003836 phosphorylation site [posttranslational modification] 525381003837 metal binding site [ion binding]; metal-binding site 525381003838 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 525381003839 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 525381003840 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 525381003841 active site 525381003842 P-loop; other site 525381003843 phosphorylation site [posttranslational modification] 525381003844 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 525381003845 beta-galactosidase; Region: BGL; TIGR03356 525381003846 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 525381003847 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 525381003848 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 525381003849 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 525381003850 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 525381003851 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 525381003852 dimer interface [polypeptide binding]; other site 525381003853 putative radical transfer pathway; other site 525381003854 diiron center [ion binding]; other site 525381003855 tyrosyl radical; other site 525381003856 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 525381003857 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 525381003858 Class I ribonucleotide reductase; Region: RNR_I; cd01679 525381003859 active site 525381003860 dimer interface [polypeptide binding]; other site 525381003861 catalytic residues [active] 525381003862 effector binding site; other site 525381003863 R2 peptide binding site; other site 525381003864 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 525381003865 catalytic residues [active] 525381003866 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 525381003867 dimerization domain swap beta strand [polypeptide binding]; other site 525381003868 regulatory protein interface [polypeptide binding]; other site 525381003869 active site 525381003870 regulatory phosphorylation site [posttranslational modification]; other site 525381003871 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 525381003872 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 525381003873 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525381003874 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 525381003875 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 525381003876 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381003877 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381003878 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381003879 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 525381003880 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 525381003881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003882 motif II; other site 525381003883 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 525381003884 ligand binding site [chemical binding]; other site 525381003885 active site 525381003886 UGI interface [polypeptide binding]; other site 525381003887 catalytic site [active] 525381003888 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 525381003889 putative active site [active] 525381003890 nucleotide binding site [chemical binding]; other site 525381003891 nudix motif; other site 525381003892 putative metal binding site [ion binding]; other site 525381003893 dihydroorotase; Validated; Region: pyrC; PRK09357 525381003894 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525381003895 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 525381003896 active site 525381003897 multidrug efflux protein; Reviewed; Region: PRK01766 525381003898 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 525381003899 cation binding site [ion binding]; other site 525381003900 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 525381003901 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 525381003902 tetramer interface [polypeptide binding]; other site 525381003903 TPP-binding site [chemical binding]; other site 525381003904 heterodimer interface [polypeptide binding]; other site 525381003905 phosphorylation loop region [posttranslational modification] 525381003906 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 525381003907 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 525381003908 alpha subunit interface [polypeptide binding]; other site 525381003909 TPP binding site [chemical binding]; other site 525381003910 heterodimer interface [polypeptide binding]; other site 525381003911 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525381003912 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 525381003913 e3 binding domain; Region: E3_binding; pfam02817 525381003914 e3 binding domain; Region: E3_binding; pfam02817 525381003915 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 525381003916 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 525381003917 E3 interaction surface; other site 525381003918 lipoyl attachment site [posttranslational modification]; other site 525381003919 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 525381003920 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 525381003921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525381003922 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525381003923 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 525381003924 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 525381003925 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 525381003926 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 525381003927 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525381003928 active site 525381003929 DNA binding site [nucleotide binding] 525381003930 Int/Topo IB signature motif; other site 525381003931 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 525381003932 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 525381003933 Cl- selectivity filter; other site 525381003934 Cl- binding residues [ion binding]; other site 525381003935 pore gating glutamate residue; other site 525381003936 dimer interface [polypeptide binding]; other site 525381003937 H+/Cl- coupling transport residue; other site 525381003938 TrkA-C domain; Region: TrkA_C; pfam02080 525381003939 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 525381003940 RNA/DNA hybrid binding site [nucleotide binding]; other site 525381003941 active site 525381003942 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 525381003943 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 525381003944 GTP/Mg2+ binding site [chemical binding]; other site 525381003945 G4 box; other site 525381003946 G5 box; other site 525381003947 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 525381003948 G1 box; other site 525381003949 G1 box; other site 525381003950 GTP/Mg2+ binding site [chemical binding]; other site 525381003951 Switch I region; other site 525381003952 G2 box; other site 525381003953 G2 box; other site 525381003954 G3 box; other site 525381003955 G3 box; other site 525381003956 Switch II region; other site 525381003957 Switch II region; other site 525381003958 G5 box; other site 525381003959 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 525381003960 G5 domain; Region: G5; pfam07501 525381003961 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 525381003962 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 525381003963 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 525381003964 Part of AAA domain; Region: AAA_19; pfam13245 525381003965 Family description; Region: UvrD_C_2; pfam13538 525381003966 Family description; Region: UvrD_C_2; pfam13538 525381003967 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 525381003968 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 525381003969 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 525381003970 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381003971 Winged helix-turn helix; Region: HTH_29; pfam13551 525381003972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381003973 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381003974 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525381003975 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381003976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381003977 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381003978 enolase; Provisional; Region: eno; PRK00077 525381003979 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 525381003980 dimer interface [polypeptide binding]; other site 525381003981 metal binding site [ion binding]; metal-binding site 525381003982 substrate binding pocket [chemical binding]; other site 525381003983 Uncharacterized conserved protein [Function unknown]; Region: COG5506 525381003984 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 525381003985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381003986 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 525381003987 glycogen synthase; Provisional; Region: glgA; PRK00654 525381003988 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 525381003989 ADP-binding pocket [chemical binding]; other site 525381003990 homodimer interface [polypeptide binding]; other site 525381003991 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 525381003992 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525381003993 active site 525381003994 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 525381003995 dimer interface [polypeptide binding]; other site 525381003996 N-terminal domain interface [polypeptide binding]; other site 525381003997 sulfate 1 binding site; other site 525381003998 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 525381003999 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 525381004000 ligand binding site; other site 525381004001 oligomer interface; other site 525381004002 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 525381004003 dimer interface [polypeptide binding]; other site 525381004004 N-terminal domain interface [polypeptide binding]; other site 525381004005 sulfate 1 binding site; other site 525381004006 glycogen branching enzyme; Provisional; Region: PRK12313 525381004007 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 525381004008 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 525381004009 active site 525381004010 catalytic site [active] 525381004011 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 525381004012 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 525381004013 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 525381004014 tetrameric interface [polypeptide binding]; other site 525381004015 activator binding site; other site 525381004016 NADP binding site [chemical binding]; other site 525381004017 substrate binding site [chemical binding]; other site 525381004018 catalytic residues [active] 525381004019 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 525381004020 pullulanase, type I; Region: pulA_typeI; TIGR02104 525381004021 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 525381004022 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 525381004023 Ca binding site [ion binding]; other site 525381004024 active site 525381004025 catalytic site [active] 525381004026 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 525381004027 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 525381004028 nucleotide binding pocket [chemical binding]; other site 525381004029 K-X-D-G motif; other site 525381004030 catalytic site [active] 525381004031 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 525381004032 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 525381004033 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 525381004034 Dimer interface [polypeptide binding]; other site 525381004035 BRCT sequence motif; other site 525381004036 H+ Antiporter protein; Region: 2A0121; TIGR00900 525381004037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525381004038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381004039 non-specific DNA binding site [nucleotide binding]; other site 525381004040 salt bridge; other site 525381004041 sequence-specific DNA binding site [nucleotide binding]; other site 525381004042 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 525381004043 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525381004044 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381004045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381004046 ABC transporter; Region: ABC_tran_2; pfam12848 525381004047 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381004048 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525381004049 IHF dimer interface [polypeptide binding]; other site 525381004050 IHF - DNA interface [nucleotide binding]; other site 525381004051 EDD domain protein, DegV family; Region: DegV; TIGR00762 525381004052 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 525381004053 Uncharacterized conserved protein [Function unknown]; Region: COG1284 525381004054 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525381004055 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525381004056 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 525381004057 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 525381004058 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 525381004059 active site 525381004060 Riboflavin kinase; Region: Flavokinase; smart00904 525381004061 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 525381004062 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 525381004063 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 525381004064 ribosomal protein L21 leader; HMPREF0837_nc10019 525381004065 Predicted membrane protein [Function unknown]; Region: COG3619 525381004066 hypothetical protein; Validated; Region: PRK00153 525381004067 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525381004068 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381004069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381004070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381004071 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381004072 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 525381004073 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525381004074 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 525381004075 RNA binding surface [nucleotide binding]; other site 525381004076 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525381004077 active site 525381004078 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 525381004079 ATP-NAD kinase; Region: NAD_kinase; pfam01513 525381004080 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 525381004081 synthetase active site [active] 525381004082 NTP binding site [chemical binding]; other site 525381004083 metal binding site [ion binding]; metal-binding site 525381004084 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 525381004085 putative active site [active] 525381004086 putative metal binding residues [ion binding]; other site 525381004087 signature motif; other site 525381004088 putative triphosphate binding site [ion binding]; other site 525381004089 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 525381004090 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 525381004091 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381004092 active site 525381004093 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 525381004094 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 525381004095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525381004096 catalytic residue [active] 525381004097 Putative amino acid metabolism; Region: DUF1831; pfam08866 525381004098 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 525381004099 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 525381004100 CoA binding domain; Region: CoA_binding; pfam02629 525381004101 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 525381004102 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 525381004103 catalytic triad [active] 525381004104 hypothetical protein; Reviewed; Region: PRK00024 525381004105 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 525381004106 MPN+ (JAMM) motif; other site 525381004107 Zinc-binding site [ion binding]; other site 525381004108 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 525381004109 Part of AAA domain; Region: AAA_19; pfam13245 525381004110 Family description; Region: UvrD_C_2; pfam13538 525381004111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 525381004112 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 525381004113 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 525381004114 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 525381004115 active site 525381004116 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 525381004117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525381004118 DNA-binding site [nucleotide binding]; DNA binding site 525381004119 DRTGG domain; Region: DRTGG; pfam07085 525381004120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 525381004121 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 525381004122 active site 2 [active] 525381004123 active site 1 [active] 525381004124 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525381004125 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525381004126 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 525381004127 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 525381004128 hinge; other site 525381004129 active site 525381004130 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525381004131 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381004132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381004133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381004134 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381004135 GTPase CgtA; Reviewed; Region: obgE; PRK12297 525381004136 GTP1/OBG; Region: GTP1_OBG; pfam01018 525381004137 Obg GTPase; Region: Obg; cd01898 525381004138 G1 box; other site 525381004139 GTP/Mg2+ binding site [chemical binding]; other site 525381004140 Switch I region; other site 525381004141 G2 box; other site 525381004142 G3 box; other site 525381004143 Switch II region; other site 525381004144 G4 box; other site 525381004145 G5 box; other site 525381004146 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 525381004147 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 525381004148 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 525381004149 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525381004150 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 525381004151 putative ADP-binding pocket [chemical binding]; other site 525381004152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525381004153 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525381004154 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 525381004155 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 525381004156 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 525381004157 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 525381004158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525381004159 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 525381004160 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525381004161 DNA binding residues [nucleotide binding] 525381004162 DNA primase; Validated; Region: dnaG; PRK05667 525381004163 CHC2 zinc finger; Region: zf-CHC2; pfam01807 525381004164 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 525381004165 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 525381004166 active site 525381004167 metal binding site [ion binding]; metal-binding site 525381004168 interdomain interaction site; other site 525381004169 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 525381004170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381004171 Walker A/P-loop; other site 525381004172 ATP binding site [chemical binding]; other site 525381004173 Q-loop/lid; other site 525381004174 ABC transporter signature motif; other site 525381004175 Walker B; other site 525381004176 D-loop; other site 525381004177 H-loop/switch region; other site 525381004178 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525381004179 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 525381004180 TM-ABC transporter signature motif; other site 525381004181 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 525381004182 zinc binding site [ion binding]; other site 525381004183 putative ligand binding site [chemical binding]; other site 525381004184 T-box leader; HMPREF0837_nc10020 525381004185 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 525381004186 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 525381004187 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 525381004188 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 525381004189 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 525381004190 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 525381004191 conserved cys residue [active] 525381004192 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 525381004193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381004194 Coenzyme A binding pocket [chemical binding]; other site 525381004195 potential frameshift: common BLAST hit: gi|225854543|ref|YP_002736055.1| neopullulanase 525381004196 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 525381004197 potential frameshift: common BLAST hit: gi|225854543|ref|YP_002736055.1| neopullulanase 525381004198 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 525381004199 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 525381004200 homodimer interface [polypeptide binding]; other site 525381004201 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 525381004202 active site 525381004203 homodimer interface [polypeptide binding]; other site 525381004204 catalytic site [active] 525381004205 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 525381004206 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 525381004207 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 525381004208 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 525381004209 potential frameshift: common BLAST hit: gi|116515333|ref|YP_816399.1| site-specific recombinase, resolvase family protein 525381004210 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 525381004211 Recombinase; Region: Recombinase; pfam07508 525381004212 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 525381004213 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 525381004214 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 525381004215 catalytic residues [active] 525381004216 catalytic nucleophile [active] 525381004217 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 525381004218 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 525381004219 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381004220 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381004221 MobA/MobL family; Region: MobA_MobL; pfam03389 525381004222 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 525381004223 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 525381004224 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 525381004225 Walker A/P-loop; other site 525381004226 ATP binding site [chemical binding]; other site 525381004227 Q-loop/lid; other site 525381004228 ABC transporter signature motif; other site 525381004229 Walker B; other site 525381004230 D-loop; other site 525381004231 H-loop/switch region; other site 525381004232 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525381004233 ABC-ATPase subunit interface; other site 525381004234 dimer interface [polypeptide binding]; other site 525381004235 putative PBP binding regions; other site 525381004236 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 525381004237 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525381004238 ABC-ATPase subunit interface; other site 525381004239 dimer interface [polypeptide binding]; other site 525381004240 putative PBP binding regions; other site 525381004241 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 525381004242 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 525381004243 siderophore binding site; other site 525381004244 Predicted transcriptional regulator [Transcription]; Region: COG3655 525381004245 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 525381004246 TRAM domain; Region: TRAM; cl01282 525381004247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381004248 S-adenosylmethionine binding site [chemical binding]; other site 525381004249 Predicted secreted protein [Function unknown]; Region: COG4086 525381004250 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 525381004251 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 525381004252 Lysozyme-like; Region: Lysozyme_like; pfam13702 525381004253 catalytic residue [active] 525381004254 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 525381004255 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 525381004256 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 525381004257 dimer interface [polypeptide binding]; other site 525381004258 active site 525381004259 glycine-pyridoxal phosphate binding site [chemical binding]; other site 525381004260 folate binding site [chemical binding]; other site 525381004261 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 525381004262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381004263 Coenzyme A binding pocket [chemical binding]; other site 525381004264 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 525381004265 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 525381004266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381004267 S-adenosylmethionine binding site [chemical binding]; other site 525381004268 peptide chain release factor 1; Validated; Region: prfA; PRK00591 525381004269 This domain is found in peptide chain release factors; Region: PCRF; smart00937 525381004270 RF-1 domain; Region: RF-1; pfam00472 525381004271 thymidine kinase; Provisional; Region: PRK04296 525381004272 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 525381004273 active site 1 [active] 525381004274 dimer interface [polypeptide binding]; other site 525381004275 hexamer interface [polypeptide binding]; other site 525381004276 active site 2 [active] 525381004277 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 525381004278 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 525381004279 trmE is a tRNA modification GTPase; Region: trmE; cd04164 525381004280 G1 box; other site 525381004281 GTP/Mg2+ binding site [chemical binding]; other site 525381004282 Switch I region; other site 525381004283 G2 box; other site 525381004284 Switch II region; other site 525381004285 G3 box; other site 525381004286 G4 box; other site 525381004287 G5 box; other site 525381004288 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 525381004289 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 525381004290 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 525381004291 dimer interface [polypeptide binding]; other site 525381004292 active site 525381004293 catalytic residue [active] 525381004294 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 525381004295 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 525381004296 Predicted membrane protein [Function unknown]; Region: COG4708 525381004297 Predicted membrane protein [Function unknown]; Region: COG2246 525381004298 GtrA-like protein; Region: GtrA; pfam04138 525381004299 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 525381004300 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 525381004301 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 525381004302 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 525381004303 active site 525381004304 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 525381004305 active site 525381004306 N-terminal domain interface [polypeptide binding]; other site 525381004307 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 525381004308 active site 525381004309 catalytic site [active] 525381004310 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 525381004311 active site 525381004312 catalytic site [active] 525381004313 T surface-antigen of pili; Region: FctA; cl16948 525381004314 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 525381004315 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 525381004316 Catalytic site [active] 525381004317 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 525381004318 metal ion-dependent adhesion site (MIDAS); other site 525381004319 peptidase T; Region: peptidase-T; TIGR01882 525381004320 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 525381004321 metal binding site [ion binding]; metal-binding site 525381004322 dimer interface [polypeptide binding]; other site 525381004323 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 525381004324 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 525381004325 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004326 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004327 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004328 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 525381004329 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004330 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004331 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004332 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004333 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 525381004334 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004335 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004336 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 525381004337 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 525381004338 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 525381004339 metal binding site [ion binding]; metal-binding site 525381004340 amino acid transporter; Region: 2A0306; TIGR00909 525381004341 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 525381004342 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 525381004343 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525381004344 catalytic residues [active] 525381004345 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 525381004346 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 525381004347 Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045 525381004348 dimer interface [polypeptide binding]; other site 525381004349 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381004350 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381004351 Winged helix-turn helix; Region: HTH_29; pfam13551 525381004352 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525381004353 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381004354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381004355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381004356 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381004357 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 525381004358 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 525381004359 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 525381004360 putative active site [active] 525381004361 catalytic site [active] 525381004362 putative metal binding site [ion binding]; other site 525381004363 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 525381004364 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 525381004365 active site 525381004366 catalytic site [active] 525381004367 substrate binding site [chemical binding]; other site 525381004368 MarR family; Region: MarR_2; cl17246 525381004369 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 525381004370 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 525381004371 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 525381004372 dimer interface [polypeptide binding]; other site 525381004373 ADP-ribose binding site [chemical binding]; other site 525381004374 active site 525381004375 nudix motif; other site 525381004376 metal binding site [ion binding]; metal-binding site 525381004377 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 525381004378 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 525381004379 Substrate binding site; other site 525381004380 Mg++ binding site; other site 525381004381 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 525381004382 active site 525381004383 substrate binding site [chemical binding]; other site 525381004384 CoA binding site [chemical binding]; other site 525381004385 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 525381004386 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 525381004387 active site 525381004388 Predicted membrane protein [Function unknown]; Region: COG2035 525381004389 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 525381004390 putative deacylase active site [active] 525381004391 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525381004392 catalytic core [active] 525381004393 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 525381004394 Integrase core domain; Region: rve; pfam00665 525381004395 Integrase core domain; Region: rve_2; pfam13333 525381004396 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 525381004397 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 525381004398 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 525381004399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381004400 S-adenosylmethionine binding site [chemical binding]; other site 525381004401 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 525381004402 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 525381004403 active site 525381004404 Zn binding site [ion binding]; other site 525381004405 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 525381004406 tellurite resistance protein TehB; Provisional; Region: PRK12335 525381004407 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 525381004408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381004409 S-adenosylmethionine binding site [chemical binding]; other site 525381004410 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 525381004411 SmpB-tmRNA interface; other site 525381004412 ribonuclease R; Region: RNase_R; TIGR02063 525381004413 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 525381004414 RNB domain; Region: RNB; pfam00773 525381004415 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 525381004416 RNA binding site [nucleotide binding]; other site 525381004417 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 525381004418 drug efflux system protein MdtG; Provisional; Region: PRK09874 525381004419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525381004420 putative substrate translocation pore; other site 525381004421 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 525381004422 dephospho-CoA kinase; Region: TIGR00152 525381004423 CoA-binding site [chemical binding]; other site 525381004424 ATP-binding [chemical binding]; other site 525381004425 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 525381004426 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 525381004427 DNA binding site [nucleotide binding] 525381004428 catalytic residue [active] 525381004429 H2TH interface [polypeptide binding]; other site 525381004430 putative catalytic residues [active] 525381004431 turnover-facilitating residue; other site 525381004432 intercalation triad [nucleotide binding]; other site 525381004433 8OG recognition residue [nucleotide binding]; other site 525381004434 putative reading head residues; other site 525381004435 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 525381004436 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 525381004437 GTPase Era; Reviewed; Region: era; PRK00089 525381004438 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 525381004439 G1 box; other site 525381004440 GTP/Mg2+ binding site [chemical binding]; other site 525381004441 Switch I region; other site 525381004442 G2 box; other site 525381004443 Switch II region; other site 525381004444 G3 box; other site 525381004445 G4 box; other site 525381004446 G5 box; other site 525381004447 KH domain; Region: KH_2; pfam07650 525381004448 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 525381004449 metal-binding heat shock protein; Provisional; Region: PRK00016 525381004450 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 525381004451 Domain of unknown function (DUF814); Region: DUF814; pfam05670 525381004452 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525381004453 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 525381004454 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 525381004455 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 525381004456 heterodimer interface [polypeptide binding]; other site 525381004457 active site 525381004458 FMN binding site [chemical binding]; other site 525381004459 homodimer interface [polypeptide binding]; other site 525381004460 substrate binding site [chemical binding]; other site 525381004461 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 525381004462 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 525381004463 FAD binding pocket [chemical binding]; other site 525381004464 FAD binding motif [chemical binding]; other site 525381004465 phosphate binding motif [ion binding]; other site 525381004466 beta-alpha-beta structure motif; other site 525381004467 NAD binding pocket [chemical binding]; other site 525381004468 Iron coordination center [ion binding]; other site 525381004469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 525381004470 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 525381004471 dimer interface [polypeptide binding]; other site 525381004472 active site 525381004473 metal binding site [ion binding]; metal-binding site 525381004474 glutathione binding site [chemical binding]; other site 525381004475 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 525381004476 23S rRNA binding site [nucleotide binding]; other site 525381004477 L21 binding site [polypeptide binding]; other site 525381004478 L13 binding site [polypeptide binding]; other site 525381004479 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 525381004480 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 525381004481 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 525381004482 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 525381004483 ribosomal protein L20 leader; HMPREF0837_nc10021 525381004484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525381004485 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525381004486 Walker A/P-loop; other site 525381004487 ATP binding site [chemical binding]; other site 525381004488 Q-loop/lid; other site 525381004489 ABC transporter signature motif; other site 525381004490 Walker B; other site 525381004491 D-loop; other site 525381004492 H-loop/switch region; other site 525381004493 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 525381004494 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 525381004495 Competence protein; Region: Competence; pfam03772 525381004496 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 525381004497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525381004498 SLBB domain; Region: SLBB; pfam10531 525381004499 comEA protein; Region: comE; TIGR01259 525381004500 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 525381004501 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525381004502 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525381004503 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 525381004504 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 525381004505 NAD binding site [chemical binding]; other site 525381004506 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 525381004507 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 525381004508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525381004509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381004510 Coenzyme A binding pocket [chemical binding]; other site 525381004511 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 525381004512 PhoH-like protein; Region: PhoH; pfam02562 525381004513 hypothetical protein; Provisional; Region: PRK13672 525381004514 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 525381004515 S1 domain; Region: S1_2; pfam13509 525381004516 ribosome recycling factor; Reviewed; Region: frr; PRK00083 525381004517 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 525381004518 hinge region; other site 525381004519 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 525381004520 putative nucleotide binding site [chemical binding]; other site 525381004521 uridine monophosphate binding site [chemical binding]; other site 525381004522 homohexameric interface [polypeptide binding]; other site 525381004523 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 525381004524 Glucose inhibited division protein A; Region: GIDA; pfam01134 525381004525 Predicted methyltransferases [General function prediction only]; Region: COG0313 525381004526 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 525381004527 putative SAM binding site [chemical binding]; other site 525381004528 putative homodimer interface [polypeptide binding]; other site 525381004529 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 525381004530 DNA polymerase III subunit delta'; Validated; Region: PRK07276 525381004531 DNA polymerase III subunit delta'; Validated; Region: PRK08485 525381004532 thymidylate kinase; Validated; Region: tmk; PRK00698 525381004533 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 525381004534 TMP-binding site; other site 525381004535 ATP-binding site [chemical binding]; other site 525381004536 pyrroline-5-carboxylate reductase; Region: PLN02688 525381004537 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 525381004538 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 525381004539 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 525381004540 putative catalytic cysteine [active] 525381004541 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 525381004542 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 525381004543 nucleotide binding site [chemical binding]; other site 525381004544 homotetrameric interface [polypeptide binding]; other site 525381004545 putative phosphate binding site [ion binding]; other site 525381004546 putative allosteric binding site; other site 525381004547 PUA domain; Region: PUA; pfam01472 525381004548 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 525381004549 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525381004550 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525381004551 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525381004552 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525381004553 RNA binding surface [nucleotide binding]; other site 525381004554 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525381004555 active site 525381004556 lipoprotein signal peptidase; Provisional; Region: PRK14797 525381004557 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525381004558 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525381004559 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 525381004560 dimerization interface [polypeptide binding]; other site 525381004561 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 525381004562 CAAX protease self-immunity; Region: Abi; pfam02517 525381004563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381004564 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525381004565 active site 525381004566 motif I; other site 525381004567 motif II; other site 525381004568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381004569 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 525381004570 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 525381004571 putative active site; other site 525381004572 catalytic triad [active] 525381004573 putative dimer interface [polypeptide binding]; other site 525381004574 agmatine deiminase; Provisional; Region: PRK13551 525381004575 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 525381004576 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 525381004577 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 525381004578 dimer interface [polypeptide binding]; other site 525381004579 active site 525381004580 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525381004581 catalytic residues [active] 525381004582 substrate binding site [chemical binding]; other site 525381004583 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 525381004584 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 525381004585 spermidine synthase; Provisional; Region: PRK00811 525381004586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381004587 S-adenosylmethionine binding site [chemical binding]; other site 525381004588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 525381004589 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525381004590 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 525381004591 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 525381004592 homodimer interface [polypeptide binding]; other site 525381004593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381004594 catalytic residue [active] 525381004595 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 525381004596 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 525381004597 Helix-turn-helix domain; Region: HTH_38; pfam13936 525381004598 Integrase core domain; Region: rve; pfam00665 525381004599 CCC1-related family of proteins; Region: CCC1_like; cl00278 525381004600 FtsX-like permease family; Region: FtsX; pfam02687 525381004601 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525381004602 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525381004603 Walker A/P-loop; other site 525381004604 ATP binding site [chemical binding]; other site 525381004605 Q-loop/lid; other site 525381004606 ABC transporter signature motif; other site 525381004607 Walker B; other site 525381004608 D-loop; other site 525381004609 H-loop/switch region; other site 525381004610 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 525381004611 SprT homologues; Region: SprT; cl01182 525381004612 hypothetical protein; Provisional; Region: PRK04351 525381004613 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 525381004614 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 525381004615 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 525381004616 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 525381004617 RNA binding site [nucleotide binding]; other site 525381004618 Predicted permeases [General function prediction only]; Region: COG0701 525381004619 Predicted membrane protein [Function unknown]; Region: COG3689 525381004620 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 525381004621 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 525381004622 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381004623 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525381004624 pyruvate kinase; Provisional; Region: PRK05826 525381004625 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 525381004626 domain interfaces; other site 525381004627 active site 525381004628 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 525381004629 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 525381004630 active site 525381004631 ADP/pyrophosphate binding site [chemical binding]; other site 525381004632 dimerization interface [polypeptide binding]; other site 525381004633 allosteric effector site; other site 525381004634 fructose-1,6-bisphosphate binding site; other site 525381004635 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 525381004636 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 525381004637 active site 525381004638 PHP Thumb interface [polypeptide binding]; other site 525381004639 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 525381004640 generic binding surface II; other site 525381004641 generic binding surface I; other site 525381004642 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 525381004643 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 525381004644 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 525381004645 Arginine repressor [Transcription]; Region: ArgR; COG1438 525381004646 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 525381004647 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 525381004648 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 525381004649 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 525381004650 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 525381004651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525381004652 ATP binding site [chemical binding]; other site 525381004653 putative Mg++ binding site [ion binding]; other site 525381004654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 525381004655 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 525381004656 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 525381004657 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 525381004658 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525381004659 active site 525381004660 catalytic residues [active] 525381004661 DNA binding site [nucleotide binding] 525381004662 Int/Topo IB signature motif; other site 525381004663 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 525381004664 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 525381004665 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 525381004666 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 525381004667 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 525381004668 HsdM N-terminal domain; Region: HsdM_N; pfam12161 525381004669 Methyltransferase domain; Region: Methyltransf_26; pfam13659 525381004670 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 525381004671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 525381004672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 525381004673 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 525381004674 Putative esterase; Region: Esterase; pfam00756 525381004675 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 525381004676 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 525381004677 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 525381004678 Ligand Binding Site [chemical binding]; other site 525381004679 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 525381004680 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 525381004681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525381004682 catalytic residue [active] 525381004683 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525381004684 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 525381004685 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 525381004686 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 525381004687 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 525381004688 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 525381004689 active site 525381004690 phosphorylation site [posttranslational modification] 525381004691 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 525381004692 active site 525381004693 P-loop; other site 525381004694 phosphorylation site [posttranslational modification] 525381004695 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 525381004696 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 525381004697 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 525381004698 putative substrate binding site [chemical binding]; other site 525381004699 putative ATP binding site [chemical binding]; other site 525381004700 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 525381004701 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 525381004702 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 525381004703 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525381004704 Domain of unknown function DUF20; Region: UPF0118; pfam01594 525381004705 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 525381004706 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 525381004707 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 525381004708 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 525381004709 FeS assembly protein SufB; Region: sufB; TIGR01980 525381004710 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 525381004711 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 525381004712 trimerization site [polypeptide binding]; other site 525381004713 active site 525381004714 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 525381004715 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 525381004716 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525381004717 catalytic residue [active] 525381004718 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 525381004719 FeS assembly protein SufD; Region: sufD; TIGR01981 525381004720 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 525381004721 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 525381004722 Walker A/P-loop; other site 525381004723 ATP binding site [chemical binding]; other site 525381004724 Q-loop/lid; other site 525381004725 ABC transporter signature motif; other site 525381004726 Walker B; other site 525381004727 D-loop; other site 525381004728 H-loop/switch region; other site 525381004729 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 525381004730 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 525381004731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381004732 Walker A motif; other site 525381004733 ATP binding site [chemical binding]; other site 525381004734 Walker B motif; other site 525381004735 arginine finger; other site 525381004736 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 525381004737 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 525381004738 GAF domain; Region: GAF_2; pfam13185 525381004739 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 525381004740 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 525381004741 RNA binding site [nucleotide binding]; other site 525381004742 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 525381004743 RNA binding site [nucleotide binding]; other site 525381004744 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 525381004745 RNA binding site [nucleotide binding]; other site 525381004746 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 525381004747 RNA binding site [nucleotide binding]; other site 525381004748 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 525381004749 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 525381004750 putative substrate binding pocket [chemical binding]; other site 525381004751 AC domain interface; other site 525381004752 catalytic triad [active] 525381004753 AB domain interface; other site 525381004754 interchain disulfide; other site 525381004755 Predicted membrane protein [Function unknown]; Region: COG3817 525381004756 Protein of unknown function (DUF979); Region: DUF979; pfam06166 525381004757 Predicted membrane protein [Function unknown]; Region: COG3819 525381004758 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 525381004759 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 525381004760 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 525381004761 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 525381004762 homodimer interface [polypeptide binding]; other site 525381004763 substrate-cofactor binding pocket; other site 525381004764 catalytic residue [active] 525381004765 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 525381004766 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 525381004767 CAP-like domain; other site 525381004768 active site 525381004769 primary dimer interface [polypeptide binding]; other site 525381004770 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525381004771 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 525381004772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381004773 Mg2+ binding site [ion binding]; other site 525381004774 G-X-G motif; other site 525381004775 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 525381004776 anchoring element; other site 525381004777 dimer interface [polypeptide binding]; other site 525381004778 ATP binding site [chemical binding]; other site 525381004779 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 525381004780 active site 525381004781 putative metal-binding site [ion binding]; other site 525381004782 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 525381004783 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 525381004784 putative transposase OrfB; Reviewed; Region: PHA02517 525381004785 HTH-like domain; Region: HTH_21; pfam13276 525381004786 Integrase core domain; Region: rve; pfam00665 525381004787 Integrase core domain; Region: rve_2; pfam13333 525381004788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 525381004789 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381004790 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525381004791 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525381004792 TM-ABC transporter signature motif; other site 525381004793 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525381004794 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525381004795 TM-ABC transporter signature motif; other site 525381004796 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 525381004797 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 525381004798 Walker A/P-loop; other site 525381004799 ATP binding site [chemical binding]; other site 525381004800 Q-loop/lid; other site 525381004801 ABC transporter signature motif; other site 525381004802 Walker B; other site 525381004803 D-loop; other site 525381004804 H-loop/switch region; other site 525381004805 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 525381004806 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 525381004807 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 525381004808 ligand binding site [chemical binding]; other site 525381004809 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 525381004810 active site 525381004811 catalytic motif [active] 525381004812 Zn binding site [ion binding]; other site 525381004813 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 525381004814 intersubunit interface [polypeptide binding]; other site 525381004815 active site 525381004816 catalytic residue [active] 525381004817 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 525381004818 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 525381004819 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 525381004820 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 525381004821 Methyltransferase domain; Region: Methyltransf_31; pfam13847 525381004822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381004823 S-adenosylmethionine binding site [chemical binding]; other site 525381004824 pantothenate kinase; Provisional; Region: PRK05439 525381004825 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 525381004826 ATP-binding site [chemical binding]; other site 525381004827 CoA-binding site [chemical binding]; other site 525381004828 Mg2+-binding site [ion binding]; other site 525381004829 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 525381004830 topology modulation protein; Provisional; Region: PRK07261 525381004831 AAA domain; Region: AAA_17; pfam13207 525381004832 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 525381004833 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 525381004834 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 525381004835 nucleophilic elbow; other site 525381004836 catalytic triad; other site 525381004837 purine nucleoside phosphorylase; Provisional; Region: PRK08202 525381004838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 525381004839 phosphopentomutase; Provisional; Region: PRK05362 525381004840 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 525381004841 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 525381004842 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525381004843 active site 525381004844 dimer interface [polypeptide binding]; other site 525381004845 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 525381004846 putative substrate binding site [chemical binding]; other site 525381004847 putative ATP binding site [chemical binding]; other site 525381004848 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 525381004849 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 525381004850 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 525381004851 homodimer interface [polypeptide binding]; other site 525381004852 NADP binding site [chemical binding]; other site 525381004853 substrate binding site [chemical binding]; other site 525381004854 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525381004855 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525381004856 Walker A/P-loop; other site 525381004857 ATP binding site [chemical binding]; other site 525381004858 Q-loop/lid; other site 525381004859 ABC transporter signature motif; other site 525381004860 Walker B; other site 525381004861 D-loop; other site 525381004862 H-loop/switch region; other site 525381004863 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525381004864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381004865 dimer interface [polypeptide binding]; other site 525381004866 conserved gate region; other site 525381004867 putative PBP binding loops; other site 525381004868 ABC-ATPase subunit interface; other site 525381004869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 525381004870 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 525381004871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381004872 Walker A motif; other site 525381004873 ATP binding site [chemical binding]; other site 525381004874 Walker B motif; other site 525381004875 arginine finger; other site 525381004876 UvrB/uvrC motif; Region: UVR; pfam02151 525381004877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381004878 Walker A motif; other site 525381004879 ATP binding site [chemical binding]; other site 525381004880 Walker B motif; other site 525381004881 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 525381004882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381004883 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381004884 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381004885 Winged helix-turn helix; Region: HTH_29; pfam13551 525381004886 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 525381004887 nudix motif; other site 525381004888 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 525381004889 putative transposase OrfB; Reviewed; Region: PHA02517 525381004890 HTH-like domain; Region: HTH_21; pfam13276 525381004891 Integrase core domain; Region: rve; pfam00665 525381004892 Integrase core domain; Region: rve_2; pfam13333 525381004893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 525381004894 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381004895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 525381004896 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 525381004897 potential frameshift: common BLAST hit: gi|116516202|ref|YP_816134.1| transposase family protein 525381004898 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381004899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381004900 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381004901 Winged helix-turn helix; Region: HTH_33; pfam13592 525381004902 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 525381004903 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 525381004904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381004905 Mg2+ binding site [ion binding]; other site 525381004906 G-X-G motif; other site 525381004907 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 525381004908 anchoring element; other site 525381004909 dimer interface [polypeptide binding]; other site 525381004910 ATP binding site [chemical binding]; other site 525381004911 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 525381004912 active site 525381004913 putative metal-binding site [ion binding]; other site 525381004914 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 525381004915 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 525381004916 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381004917 motif II; other site 525381004918 DJ-1 family protein; Region: not_thiJ; TIGR01383 525381004919 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 525381004920 conserved cys residue [active] 525381004921 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 525381004922 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 525381004923 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 525381004924 active site 525381004925 catalytic site [active] 525381004926 substrate binding site [chemical binding]; other site 525381004927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525381004928 ATP binding site [chemical binding]; other site 525381004929 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 525381004930 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 525381004931 Peptidase family U32; Region: Peptidase_U32; pfam01136 525381004932 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 525381004933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525381004934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525381004935 dimer interface [polypeptide binding]; other site 525381004936 phosphorylation site [posttranslational modification] 525381004937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381004938 ATP binding site [chemical binding]; other site 525381004939 Mg2+ binding site [ion binding]; other site 525381004940 G-X-G motif; other site 525381004941 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525381004942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381004943 active site 525381004944 phosphorylation site [posttranslational modification] 525381004945 intermolecular recognition site; other site 525381004946 dimerization interface [polypeptide binding]; other site 525381004947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525381004948 DNA binding site [nucleotide binding] 525381004949 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 525381004950 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 525381004951 Zn binding site [ion binding]; other site 525381004952 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 525381004953 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 525381004954 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 525381004955 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 525381004956 nudix motif; other site 525381004957 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 525381004958 classical (c) SDRs; Region: SDR_c; cd05233 525381004959 NAD(P) binding site [chemical binding]; other site 525381004960 active site 525381004961 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 525381004962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 525381004963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 525381004964 active site 525381004965 catalytic tetrad [active] 525381004966 Predicted transcriptional regulators [Transcription]; Region: COG1695 525381004967 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 525381004968 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 525381004969 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 525381004970 active site 525381004971 HIGH motif; other site 525381004972 KMSKS motif; other site 525381004973 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 525381004974 tRNA binding surface [nucleotide binding]; other site 525381004975 anticodon binding site; other site 525381004976 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 525381004977 dimer interface [polypeptide binding]; other site 525381004978 putative tRNA-binding site [nucleotide binding]; other site 525381004979 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525381004980 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525381004981 FtsX-like permease family; Region: FtsX; pfam02687 525381004982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525381004983 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525381004984 Walker A/P-loop; other site 525381004985 ATP binding site [chemical binding]; other site 525381004986 Q-loop/lid; other site 525381004987 ABC transporter signature motif; other site 525381004988 Walker B; other site 525381004989 D-loop; other site 525381004990 H-loop/switch region; other site 525381004991 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525381004992 HlyD family secretion protein; Region: HlyD_3; pfam13437 525381004993 glutathione reductase; Validated; Region: PRK06116 525381004994 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525381004995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525381004996 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525381004997 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 525381004998 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 525381004999 ATP cone domain; Region: ATP-cone; pfam03477 525381005000 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 525381005001 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 525381005002 RimM N-terminal domain; Region: RimM; pfam01782 525381005003 PRC-barrel domain; Region: PRC; pfam05239 525381005004 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 525381005005 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381005006 elongation factor Tu; Reviewed; Region: PRK00049 525381005007 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 525381005008 G1 box; other site 525381005009 GEF interaction site [polypeptide binding]; other site 525381005010 GTP/Mg2+ binding site [chemical binding]; other site 525381005011 Switch I region; other site 525381005012 G2 box; other site 525381005013 G3 box; other site 525381005014 Switch II region; other site 525381005015 G4 box; other site 525381005016 G5 box; other site 525381005017 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 525381005018 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 525381005019 Antibiotic Binding Site [chemical binding]; other site 525381005020 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 525381005021 amphipathic channel; other site 525381005022 Asn-Pro-Ala signature motifs; other site 525381005023 MucBP domain; Region: MucBP; pfam06458 525381005024 DDE superfamily endonuclease; Region: DDE_3; pfam13358 525381005025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 525381005026 Transposase; Region: HTH_Tnp_IS630; pfam01710 525381005027 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381005028 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 525381005029 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 525381005030 active site 525381005031 substrate binding site [chemical binding]; other site 525381005032 metal binding site [ion binding]; metal-binding site 525381005033 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525381005034 catalytic residues [active] 525381005035 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525381005036 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525381005037 substrate binding pocket [chemical binding]; other site 525381005038 membrane-bound complex binding site; other site 525381005039 hinge residues; other site 525381005040 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525381005041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381005042 Walker A/P-loop; other site 525381005043 ATP binding site [chemical binding]; other site 525381005044 Q-loop/lid; other site 525381005045 ABC transporter signature motif; other site 525381005046 Walker B; other site 525381005047 D-loop; other site 525381005048 H-loop/switch region; other site 525381005049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381005050 dimer interface [polypeptide binding]; other site 525381005051 conserved gate region; other site 525381005052 putative PBP binding loops; other site 525381005053 ABC-ATPase subunit interface; other site 525381005054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 525381005055 TPR motif; other site 525381005056 binding surface 525381005057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525381005058 binding surface 525381005059 TPR motif; other site 525381005060 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525381005061 Domain of unknown function DUF20; Region: UPF0118; pfam01594 525381005062 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 525381005063 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 525381005064 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 525381005065 gamma subunit interface [polypeptide binding]; other site 525381005066 epsilon subunit interface [polypeptide binding]; other site 525381005067 LBP interface [polypeptide binding]; other site 525381005068 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 525381005069 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525381005070 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 525381005071 alpha subunit interaction interface [polypeptide binding]; other site 525381005072 Walker A motif; other site 525381005073 ATP binding site [chemical binding]; other site 525381005074 Walker B motif; other site 525381005075 inhibitor binding site; inhibition site 525381005076 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525381005077 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 525381005078 core domain interface [polypeptide binding]; other site 525381005079 delta subunit interface [polypeptide binding]; other site 525381005080 epsilon subunit interface [polypeptide binding]; other site 525381005081 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 525381005082 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525381005083 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 525381005084 beta subunit interaction interface [polypeptide binding]; other site 525381005085 Walker A motif; other site 525381005086 ATP binding site [chemical binding]; other site 525381005087 Walker B motif; other site 525381005088 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525381005089 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 525381005090 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 525381005091 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 525381005092 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 525381005093 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 525381005094 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 525381005095 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 525381005096 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 525381005097 Helix-turn-helix domain; Region: HTH_38; pfam13936 525381005098 Integrase core domain; Region: rve; pfam00665 525381005099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381005100 Coenzyme A binding pocket [chemical binding]; other site 525381005101 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 525381005102 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 525381005103 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 525381005104 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 525381005105 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 525381005106 dimerization interface [polypeptide binding]; other site 525381005107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 525381005108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381005109 Coenzyme A binding pocket [chemical binding]; other site 525381005110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381005111 Coenzyme A binding pocket [chemical binding]; other site 525381005112 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 525381005113 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525381005114 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525381005115 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525381005116 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 525381005117 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 525381005118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525381005119 ATP binding site [chemical binding]; other site 525381005120 putative Mg++ binding site [ion binding]; other site 525381005121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525381005122 nucleotide binding region [chemical binding]; other site 525381005123 ATP-binding site [chemical binding]; other site 525381005124 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 525381005125 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525381005126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381005127 homodimer interface [polypeptide binding]; other site 525381005128 catalytic residue [active] 525381005129 cystathionine gamma-synthase; Reviewed; Region: PRK07269 525381005130 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 525381005131 homodimer interface [polypeptide binding]; other site 525381005132 substrate-cofactor binding pocket; other site 525381005133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381005134 catalytic residue [active] 525381005135 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381005136 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525381005137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381005138 Walker A/P-loop; other site 525381005139 ATP binding site [chemical binding]; other site 525381005140 Q-loop/lid; other site 525381005141 ABC transporter signature motif; other site 525381005142 Walker B; other site 525381005143 D-loop; other site 525381005144 H-loop/switch region; other site 525381005145 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 525381005146 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 525381005147 peptide binding site [polypeptide binding]; other site 525381005148 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 525381005149 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 525381005150 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 525381005151 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525381005152 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525381005153 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525381005154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 525381005155 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 525381005156 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 525381005157 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 525381005158 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 525381005159 DHH family; Region: DHH; pfam01368 525381005160 DHHA2 domain; Region: DHHA2; pfam02833 525381005161 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 525381005162 GIY-YIG motif/motif A; other site 525381005163 putative active site [active] 525381005164 putative metal binding site [ion binding]; other site 525381005165 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 525381005166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381005167 S-adenosylmethionine binding site [chemical binding]; other site 525381005168 hypothetical protein; Provisional; Region: PRK07252 525381005169 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 525381005170 RNA binding site [nucleotide binding]; other site 525381005171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381005172 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525381005173 active site 525381005174 motif I; other site 525381005175 motif II; other site 525381005176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381005177 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 525381005178 active site 525381005179 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 525381005180 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 525381005181 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 525381005182 dimer interface [polypeptide binding]; other site 525381005183 ssDNA binding site [nucleotide binding]; other site 525381005184 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525381005185 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 525381005186 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 525381005187 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 525381005188 putative dimer interface [polypeptide binding]; other site 525381005189 putative anticodon binding site; other site 525381005190 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 525381005191 homodimer interface [polypeptide binding]; other site 525381005192 motif 1; other site 525381005193 motif 2; other site 525381005194 active site 525381005195 motif 3; other site 525381005196 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 525381005197 active site 525381005198 aspartate aminotransferase; Provisional; Region: PRK05764 525381005199 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525381005200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381005201 homodimer interface [polypeptide binding]; other site 525381005202 catalytic residue [active] 525381005203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 525381005204 Predicted flavoprotein [General function prediction only]; Region: COG0431 525381005205 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525381005206 G5 domain; Region: G5; pfam07501 525381005207 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 525381005208 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 525381005209 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 525381005210 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 525381005211 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 525381005212 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 525381005213 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 525381005214 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 525381005215 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 525381005216 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 525381005217 Mga helix-turn-helix domain; Region: Mga; pfam05043 525381005218 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 525381005219 hypothetical protein; Validated; Region: PRK02101 525381005220 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 525381005221 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 525381005222 active site 525381005223 catalytic residues [active] 525381005224 metal binding site [ion binding]; metal-binding site 525381005225 putative S-transferase; Provisional; Region: PRK11752 525381005226 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 525381005227 C-terminal domain interface [polypeptide binding]; other site 525381005228 GSH binding site (G-site) [chemical binding]; other site 525381005229 dimer interface [polypeptide binding]; other site 525381005230 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 525381005231 N-terminal domain interface [polypeptide binding]; other site 525381005232 dimer interface [polypeptide binding]; other site 525381005233 substrate binding pocket (H-site) [chemical binding]; other site 525381005234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 525381005235 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 525381005236 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525381005237 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 525381005238 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 525381005239 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 525381005240 yybP-ykoY leader; HMPREF0837_nc10023 525381005241 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 525381005242 Cation efflux family; Region: Cation_efflux; pfam01545 525381005243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 525381005244 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525381005245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381005246 Walker A/P-loop; other site 525381005247 ATP binding site [chemical binding]; other site 525381005248 Q-loop/lid; other site 525381005249 ABC transporter signature motif; other site 525381005250 Walker B; other site 525381005251 D-loop; other site 525381005252 H-loop/switch region; other site 525381005253 ABC transporter; Region: ABC_tran_2; pfam12848 525381005254 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381005255 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 525381005256 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 525381005257 active site 525381005258 NTP binding site [chemical binding]; other site 525381005259 metal binding triad [ion binding]; metal-binding site 525381005260 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 525381005261 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 525381005262 dihydrodipicolinate reductase; Provisional; Region: PRK00048 525381005263 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 525381005264 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 525381005265 EDD domain protein, DegV family; Region: DegV; TIGR00762 525381005266 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 525381005267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 525381005268 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 525381005269 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 525381005270 active site 525381005271 substrate binding site [chemical binding]; other site 525381005272 metal binding site [ion binding]; metal-binding site 525381005273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 525381005274 YbbR-like protein; Region: YbbR; pfam07949 525381005275 Uncharacterized conserved protein [Function unknown]; Region: COG1624 525381005276 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 525381005277 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 525381005278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525381005279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525381005280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 525381005281 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 525381005282 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 525381005283 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 525381005284 dimer interface [polypeptide binding]; other site 525381005285 phosphate binding site [ion binding]; other site 525381005286 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 525381005287 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 525381005288 homotrimer interaction site [polypeptide binding]; other site 525381005289 putative active site [active] 525381005290 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 525381005291 G1 box; other site 525381005292 GTP/Mg2+ binding site [chemical binding]; other site 525381005293 Switch I region; other site 525381005294 G2 box; other site 525381005295 G3 box; other site 525381005296 Switch II region; other site 525381005297 G4 box; other site 525381005298 G5 box; other site 525381005299 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 525381005300 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 525381005301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381005302 Walker A motif; other site 525381005303 ATP binding site [chemical binding]; other site 525381005304 Walker B motif; other site 525381005305 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 525381005306 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 525381005307 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 525381005308 folate binding site [chemical binding]; other site 525381005309 NADP+ binding site [chemical binding]; other site 525381005310 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 525381005311 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 525381005312 dimerization interface [polypeptide binding]; other site 525381005313 DPS ferroxidase diiron center [ion binding]; other site 525381005314 ion pore; other site 525381005315 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525381005316 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 525381005317 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 525381005318 active site 525381005319 triosephosphate isomerase; Provisional; Region: PRK14567 525381005320 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 525381005321 substrate binding site [chemical binding]; other site 525381005322 dimer interface [polypeptide binding]; other site 525381005323 catalytic triad [active] 525381005324 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 525381005325 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 525381005326 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 525381005327 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 525381005328 proposed active site lysine [active] 525381005329 conserved cys residue [active] 525381005330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381005331 active site 525381005332 Methyltransferase domain; Region: Methyltransf_31; pfam13847 525381005333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381005334 S-adenosylmethionine binding site [chemical binding]; other site 525381005335 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 525381005336 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 525381005337 Walker A/P-loop; other site 525381005338 ATP binding site [chemical binding]; other site 525381005339 Q-loop/lid; other site 525381005340 ABC transporter signature motif; other site 525381005341 Walker B; other site 525381005342 D-loop; other site 525381005343 H-loop/switch region; other site 525381005344 TOBE domain; Region: TOBE_2; pfam08402 525381005345 Isochorismatase family; Region: Isochorismatase; pfam00857 525381005346 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 525381005347 catalytic triad [active] 525381005348 conserved cis-peptide bond; other site 525381005349 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 525381005350 CodY GAF-like domain; Region: CodY; pfam06018 525381005351 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525381005352 putative DNA binding site [nucleotide binding]; other site 525381005353 putative Zn2+ binding site [ion binding]; other site 525381005354 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 525381005355 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 525381005356 ATP binding site [chemical binding]; other site 525381005357 Mg++ binding site [ion binding]; other site 525381005358 motif III; other site 525381005359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525381005360 nucleotide binding region [chemical binding]; other site 525381005361 ATP-binding site [chemical binding]; other site 525381005362 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 525381005363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525381005364 putative substrate translocation pore; other site 525381005365 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 525381005366 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 525381005367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525381005368 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525381005369 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 525381005370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525381005371 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 525381005372 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 525381005373 catalytic triad [active] 525381005374 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 525381005375 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 525381005376 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 525381005377 active site 525381005378 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525381005379 putative transposase OrfB; Reviewed; Region: PHA02517 525381005380 HTH-like domain; Region: HTH_21; pfam13276 525381005381 Integrase core domain; Region: rve; pfam00665 525381005382 Integrase core domain; Region: rve_2; pfam13333 525381005383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 525381005384 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381005385 Predicted membrane protein [Function unknown]; Region: COG4720 525381005386 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 525381005387 dimer interface [polypeptide binding]; other site 525381005388 substrate binding site [chemical binding]; other site 525381005389 ATP binding site [chemical binding]; other site 525381005390 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 525381005391 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 525381005392 dimerization interface 3.5A [polypeptide binding]; other site 525381005393 active site 525381005394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525381005395 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 525381005396 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 525381005397 PhnA protein; Region: PhnA; pfam03831 525381005398 cytidylate kinase; Provisional; Region: cmk; PRK00023 525381005399 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 525381005400 CMP-binding site; other site 525381005401 The sites determining sugar specificity; other site 525381005402 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 525381005403 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 525381005404 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 525381005405 Ligand binding site; other site 525381005406 Putative Catalytic site; other site 525381005407 DXD motif; other site 525381005408 UDP-glucose 4-epimerase; Region: PLN02240 525381005409 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 525381005410 NAD binding site [chemical binding]; other site 525381005411 homodimer interface [polypeptide binding]; other site 525381005412 active site 525381005413 substrate binding site [chemical binding]; other site 525381005414 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 525381005415 Uncharacterized conserved protein [Function unknown]; Region: COG0327 525381005416 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 525381005417 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 525381005418 Family of unknown function (DUF633); Region: DUF633; pfam04816 525381005419 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 525381005420 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 525381005421 ATP binding site [chemical binding]; other site 525381005422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 525381005423 Helix-turn-helix domain; Region: HTH_28; pfam13518 525381005424 putative transposase OrfB; Reviewed; Region: PHA02517 525381005425 HTH-like domain; Region: HTH_21; pfam13276 525381005426 Integrase core domain; Region: rve; pfam00665 525381005427 Integrase core domain; Region: rve_2; pfam13333 525381005428 potential frameshift: common BLAST hit: gi|225861446|ref|YP_002742955.1| transketolase 525381005429 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 525381005430 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 525381005431 PYR/PP interface [polypeptide binding]; other site 525381005432 dimer interface [polypeptide binding]; other site 525381005433 TPP binding site [chemical binding]; other site 525381005434 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525381005435 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 525381005436 TPP-binding site [chemical binding]; other site 525381005437 dimer interface [polypeptide binding]; other site 525381005438 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 525381005439 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 525381005440 substrate binding site [chemical binding]; other site 525381005441 hexamer interface [polypeptide binding]; other site 525381005442 metal binding site [ion binding]; metal-binding site 525381005443 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 525381005444 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 525381005445 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 525381005446 active site 525381005447 P-loop; other site 525381005448 phosphorylation site [posttranslational modification] 525381005449 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 525381005450 active site 525381005451 phosphorylation site [posttranslational modification] 525381005452 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 525381005453 active site 525381005454 phosphorylation site [posttranslational modification] 525381005455 HTH domain; Region: HTH_11; pfam08279 525381005456 Mga helix-turn-helix domain; Region: Mga; pfam05043 525381005457 PRD domain; Region: PRD; pfam00874 525381005458 PRD domain; Region: PRD; pfam00874 525381005459 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 525381005460 active site 525381005461 P-loop; other site 525381005462 phosphorylation site [posttranslational modification] 525381005463 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 525381005464 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525381005465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381005466 motif II; other site 525381005467 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 525381005468 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 525381005469 putative acyl-acceptor binding pocket; other site 525381005470 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 525381005471 Cadmium resistance transporter; Region: Cad; pfam03596 525381005472 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 525381005473 16S/18S rRNA binding site [nucleotide binding]; other site 525381005474 S13e-L30e interaction site [polypeptide binding]; other site 525381005475 25S rRNA binding site [nucleotide binding]; other site 525381005476 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 525381005477 NADH(P)-binding; Region: NAD_binding_10; pfam13460 525381005478 NAD binding site [chemical binding]; other site 525381005479 substrate binding site [chemical binding]; other site 525381005480 putative active site [active] 525381005481 T-box leader; HMPREF0837_nc10024 525381005482 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 525381005483 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 525381005484 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 525381005485 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 525381005486 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 525381005487 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 525381005488 active site 525381005489 dimer interface [polypeptide binding]; other site 525381005490 motif 1; other site 525381005491 motif 2; other site 525381005492 motif 3; other site 525381005493 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 525381005494 anticodon binding site; other site 525381005495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525381005496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381005497 ATP binding site [chemical binding]; other site 525381005498 Mg2+ binding site [ion binding]; other site 525381005499 G-X-G motif; other site 525381005500 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525381005501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381005502 active site 525381005503 phosphorylation site [posttranslational modification] 525381005504 intermolecular recognition site; other site 525381005505 dimerization interface [polypeptide binding]; other site 525381005506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525381005507 DNA binding site [nucleotide binding] 525381005508 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 525381005509 nucleophilic elbow; other site 525381005510 catalytic triad; other site 525381005511 Predicted transcriptional regulator [Transcription]; Region: COG1959 525381005512 Transcriptional regulator; Region: Rrf2; pfam02082 525381005513 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 525381005514 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525381005515 active site 525381005516 metal binding site [ion binding]; metal-binding site 525381005517 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 525381005518 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 525381005519 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 525381005520 FeoA domain; Region: FeoA; pfam04023 525381005521 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381005522 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 525381005523 putative active site [active] 525381005524 dimerization interface [polypeptide binding]; other site 525381005525 putative tRNAtyr binding site [nucleotide binding]; other site 525381005526 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 525381005527 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525381005528 Zn2+ binding site [ion binding]; other site 525381005529 Mg2+ binding site [ion binding]; other site 525381005530 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 525381005531 synthetase active site [active] 525381005532 NTP binding site [chemical binding]; other site 525381005533 metal binding site [ion binding]; metal-binding site 525381005534 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 525381005535 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 525381005536 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 525381005537 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 525381005538 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 525381005539 active site 525381005540 Zn binding site [ion binding]; other site 525381005541 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 525381005542 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 525381005543 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 525381005544 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525381005545 ABC-ATPase subunit interface; other site 525381005546 dimer interface [polypeptide binding]; other site 525381005547 putative PBP binding regions; other site 525381005548 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 525381005549 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 525381005550 metal binding site [ion binding]; metal-binding site 525381005551 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 525381005552 dimer interface [polypeptide binding]; other site 525381005553 catalytic triad [active] 525381005554 peroxidatic and resolving cysteines [active] 525381005555 FtsX-like permease family; Region: FtsX; pfam02687 525381005556 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525381005557 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525381005558 FtsX-like permease family; Region: FtsX; pfam02687 525381005559 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525381005560 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525381005561 Walker A/P-loop; other site 525381005562 ATP binding site [chemical binding]; other site 525381005563 Q-loop/lid; other site 525381005564 ABC transporter signature motif; other site 525381005565 Walker B; other site 525381005566 D-loop; other site 525381005567 H-loop/switch region; other site 525381005568 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 525381005569 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525381005570 catalytic core [active] 525381005571 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525381005572 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 525381005573 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525381005574 active site 525381005575 HIGH motif; other site 525381005576 nucleotide binding site [chemical binding]; other site 525381005577 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 525381005578 active site 525381005579 KMSKS motif; other site 525381005580 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 525381005581 tRNA binding surface [nucleotide binding]; other site 525381005582 anticodon binding site; other site 525381005583 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 525381005584 T-box leader; HMPREF0837_nc10025 525381005585 DivIVA domain; Region: DivI1A_domain; TIGR03544 525381005586 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 525381005587 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 525381005588 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 525381005589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525381005590 RNA binding surface [nucleotide binding]; other site 525381005591 YGGT family; Region: YGGT; pfam02325 525381005592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 525381005593 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 525381005594 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525381005595 catalytic residue [active] 525381005596 cell division protein FtsZ; Validated; Region: PRK09330 525381005597 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 525381005598 nucleotide binding site [chemical binding]; other site 525381005599 SulA interaction site; other site 525381005600 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 525381005601 Cell division protein FtsA; Region: FtsA; smart00842 525381005602 Cell division protein FtsA; Region: FtsA; pfam14450 525381005603 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 525381005604 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 525381005605 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 525381005606 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 525381005607 nudix motif; other site 525381005608 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 525381005609 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525381005610 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525381005611 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525381005612 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 525381005613 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 525381005614 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 525381005615 recombination protein RecR; Reviewed; Region: recR; PRK00076 525381005616 RecR protein; Region: RecR; pfam02132 525381005617 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 525381005618 putative active site [active] 525381005619 putative metal-binding site [ion binding]; other site 525381005620 tetramer interface [polypeptide binding]; other site 525381005621 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 525381005622 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525381005623 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525381005624 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525381005625 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 525381005626 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 525381005627 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 525381005628 putative active site [active] 525381005629 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525381005630 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525381005631 nucleotide binding site [chemical binding]; other site 525381005632 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 525381005633 Class I aldolases; Region: Aldolase_Class_I; cl17187 525381005634 catalytic residue [active] 525381005635 Protein of unknown function, DUF624; Region: DUF624; pfam04854 525381005636 Domain of unknown function (DUF386); Region: DUF386; pfam04074 525381005637 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525381005638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381005639 dimer interface [polypeptide binding]; other site 525381005640 conserved gate region; other site 525381005641 putative PBP binding loops; other site 525381005642 ABC-ATPase subunit interface; other site 525381005643 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 525381005644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525381005645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381005646 putative PBP binding loops; other site 525381005647 dimer interface [polypeptide binding]; other site 525381005648 ABC-ATPase subunit interface; other site 525381005649 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525381005650 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525381005651 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 525381005652 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 525381005653 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 525381005654 active site turn [active] 525381005655 phosphorylation site [posttranslational modification] 525381005656 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 525381005657 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 525381005658 putative active site cavity [active] 525381005659 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 525381005660 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 525381005661 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 525381005662 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 525381005663 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 525381005664 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 525381005665 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 525381005666 Asp-box motif; other site 525381005667 catalytic site [active] 525381005668 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525381005669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381005670 dimer interface [polypeptide binding]; other site 525381005671 conserved gate region; other site 525381005672 putative PBP binding loops; other site 525381005673 ABC-ATPase subunit interface; other site 525381005674 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 525381005675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381005676 dimer interface [polypeptide binding]; other site 525381005677 conserved gate region; other site 525381005678 putative PBP binding loops; other site 525381005679 ABC-ATPase subunit interface; other site 525381005680 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525381005681 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525381005682 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 525381005683 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 525381005684 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 525381005685 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 525381005686 catalytic site [active] 525381005687 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 525381005688 Asp-box motif; other site 525381005689 Asp-box motif; other site 525381005690 catalytic site [active] 525381005691 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 525381005692 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 525381005693 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 525381005694 ssDNA binding site; other site 525381005695 generic binding surface II; other site 525381005696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525381005697 ATP binding site [chemical binding]; other site 525381005698 putative Mg++ binding site [ion binding]; other site 525381005699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525381005700 nucleotide binding region [chemical binding]; other site 525381005701 ATP-binding site [chemical binding]; other site 525381005702 alanine racemase; Reviewed; Region: alr; PRK00053 525381005703 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 525381005704 active site 525381005705 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525381005706 dimer interface [polypeptide binding]; other site 525381005707 substrate binding site [chemical binding]; other site 525381005708 catalytic residues [active] 525381005709 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 525381005710 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 525381005711 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 525381005712 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 525381005713 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 525381005714 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 525381005715 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 525381005716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525381005717 nucleotide binding region [chemical binding]; other site 525381005718 ATP-binding site [chemical binding]; other site 525381005719 SEC-C motif; Region: SEC-C; pfam02810 525381005720 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 525381005721 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525381005722 Walker A/P-loop; other site 525381005723 ATP binding site [chemical binding]; other site 525381005724 Q-loop/lid; other site 525381005725 ABC transporter signature motif; other site 525381005726 Walker B; other site 525381005727 D-loop; other site 525381005728 H-loop/switch region; other site 525381005729 GTP-binding protein Der; Reviewed; Region: PRK00093 525381005730 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 525381005731 G1 box; other site 525381005732 GTP/Mg2+ binding site [chemical binding]; other site 525381005733 Switch I region; other site 525381005734 G2 box; other site 525381005735 Switch II region; other site 525381005736 G3 box; other site 525381005737 G4 box; other site 525381005738 G5 box; other site 525381005739 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 525381005740 G1 box; other site 525381005741 GTP/Mg2+ binding site [chemical binding]; other site 525381005742 Switch I region; other site 525381005743 G2 box; other site 525381005744 G3 box; other site 525381005745 Switch II region; other site 525381005746 G4 box; other site 525381005747 G5 box; other site 525381005748 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 525381005749 dimer interface [polypeptide binding]; other site 525381005750 FMN binding site [chemical binding]; other site 525381005751 NADPH bind site [chemical binding]; other site 525381005752 primosomal protein DnaI; Reviewed; Region: PRK08939 525381005753 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 525381005754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381005755 Walker A motif; other site 525381005756 ATP binding site [chemical binding]; other site 525381005757 Walker B motif; other site 525381005758 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 525381005759 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 525381005760 ATP cone domain; Region: ATP-cone; pfam03477 525381005761 Predicted transcriptional regulators [Transcription]; Region: COG1725 525381005762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525381005763 DNA-binding site [nucleotide binding]; DNA binding site 525381005764 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 525381005765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525381005766 Walker A/P-loop; other site 525381005767 ATP binding site [chemical binding]; other site 525381005768 Q-loop/lid; other site 525381005769 ABC transporter signature motif; other site 525381005770 Walker B; other site 525381005771 D-loop; other site 525381005772 H-loop/switch region; other site 525381005773 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 525381005774 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 525381005775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381005776 Walker A/P-loop; other site 525381005777 ATP binding site [chemical binding]; other site 525381005778 Q-loop/lid; other site 525381005779 ABC transporter signature motif; other site 525381005780 Walker B; other site 525381005781 D-loop; other site 525381005782 H-loop/switch region; other site 525381005783 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 525381005784 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 525381005785 Uncharacterized conserved protein [Function unknown]; Region: COG0398 525381005786 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 525381005787 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525381005788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525381005789 nucleotide binding site [chemical binding]; other site 525381005790 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 525381005791 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 525381005792 active site turn [active] 525381005793 phosphorylation site [posttranslational modification] 525381005794 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 525381005795 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 525381005796 HPr interaction site; other site 525381005797 glycerol kinase (GK) interaction site [polypeptide binding]; other site 525381005798 active site 525381005799 phosphorylation site [posttranslational modification] 525381005800 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 525381005801 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 525381005802 substrate binding [chemical binding]; other site 525381005803 active site 525381005804 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 525381005805 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525381005806 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525381005807 DNA binding site [nucleotide binding] 525381005808 domain linker motif; other site 525381005809 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 525381005810 dimerization interface [polypeptide binding]; other site 525381005811 ligand binding site [chemical binding]; other site 525381005812 sodium binding site [ion binding]; other site 525381005813 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 525381005814 homodimer interface [polypeptide binding]; other site 525381005815 catalytic residues [active] 525381005816 NAD binding site [chemical binding]; other site 525381005817 substrate binding pocket [chemical binding]; other site 525381005818 flexible flap; other site 525381005819 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 525381005820 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 525381005821 dimer interface [polypeptide binding]; other site 525381005822 active site 525381005823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 525381005824 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 525381005825 Uncharacterized conserved protein [Function unknown]; Region: COG3610 525381005826 Uncharacterized conserved protein [Function unknown]; Region: COG2966 525381005827 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 525381005828 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 525381005829 Catalytic domain of Protein Kinases; Region: PKc; cd00180 525381005830 active site 525381005831 ATP binding site [chemical binding]; other site 525381005832 substrate binding site [chemical binding]; other site 525381005833 activation loop (A-loop); other site 525381005834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 525381005835 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525381005836 PASTA domain; Region: PASTA; smart00740 525381005837 PASTA domain; Region: PASTA; smart00740 525381005838 PASTA domain; Region: PASTA; smart00740 525381005839 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 525381005840 active site 525381005841 16S rRNA methyltransferase B; Provisional; Region: PRK14902 525381005842 NusB family; Region: NusB; pfam01029 525381005843 putative RNA binding site [nucleotide binding]; other site 525381005844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381005845 S-adenosylmethionine binding site [chemical binding]; other site 525381005846 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 525381005847 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 525381005848 putative active site [active] 525381005849 substrate binding site [chemical binding]; other site 525381005850 putative cosubstrate binding site; other site 525381005851 catalytic site [active] 525381005852 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 525381005853 substrate binding site [chemical binding]; other site 525381005854 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 525381005855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525381005856 ATP binding site [chemical binding]; other site 525381005857 putative Mg++ binding site [ion binding]; other site 525381005858 helicase superfamily c-terminal domain; Region: HELICc; smart00490 525381005859 ATP-binding site [chemical binding]; other site 525381005860 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 525381005861 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 525381005862 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 525381005863 catalytic site [active] 525381005864 G-X2-G-X-G-K; other site 525381005865 hypothetical protein; Provisional; Region: PRK00106 525381005866 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525381005867 Zn2+ binding site [ion binding]; other site 525381005868 Mg2+ binding site [ion binding]; other site 525381005869 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 525381005870 hypothetical protein; Provisional; Region: PRK13670 525381005871 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 525381005872 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 525381005873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381005874 S-adenosylmethionine binding site [chemical binding]; other site 525381005875 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 525381005876 Isochorismatase family; Region: Isochorismatase; pfam00857 525381005877 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 525381005878 catalytic triad [active] 525381005879 conserved cis-peptide bond; other site 525381005880 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525381005881 Zn2+ binding site [ion binding]; other site 525381005882 Mg2+ binding site [ion binding]; other site 525381005883 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 525381005884 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 525381005885 active site 525381005886 (T/H)XGH motif; other site 525381005887 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 525381005888 GTPase YqeH; Provisional; Region: PRK13796 525381005889 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 525381005890 GTP/Mg2+ binding site [chemical binding]; other site 525381005891 G4 box; other site 525381005892 G5 box; other site 525381005893 G1 box; other site 525381005894 Switch I region; other site 525381005895 G2 box; other site 525381005896 G3 box; other site 525381005897 Switch II region; other site 525381005898 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 525381005899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381005900 active site 525381005901 motif I; other site 525381005902 motif II; other site 525381005903 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 525381005904 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 525381005905 Cl binding site [ion binding]; other site 525381005906 oligomer interface [polypeptide binding]; other site 525381005907 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 525381005908 Mechanosensitive ion channel; Region: MS_channel; pfam00924 525381005909 potential frameshift: common BLAST hit: gi|221232489|ref|YP_002511642.1| serine/threonine transporter SstT 525381005910 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 525381005911 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 525381005912 Predicted membrane protein [Function unknown]; Region: COG4129 525381005913 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 525381005914 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 525381005915 MarR family; Region: MarR_2; pfam12802 525381005916 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525381005917 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525381005918 catalytic residues [active] 525381005919 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 525381005920 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 525381005921 amphipathic channel; other site 525381005922 Asn-Pro-Ala signature motifs; other site 525381005923 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 525381005924 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 525381005925 oligoendopeptidase F; Region: pepF; TIGR00181 525381005926 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 525381005927 Zn binding site [ion binding]; other site 525381005928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 525381005929 RNA methyltransferase, RsmE family; Region: TIGR00046 525381005930 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 525381005931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381005932 S-adenosylmethionine binding site [chemical binding]; other site 525381005933 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 525381005934 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 525381005935 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 525381005936 active site 525381005937 catalytic triad [active] 525381005938 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525381005939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381005940 Walker A motif; other site 525381005941 ATP binding site [chemical binding]; other site 525381005942 Walker B motif; other site 525381005943 arginine finger; other site 525381005944 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 525381005945 Peptidase family M50; Region: Peptidase_M50; pfam02163 525381005946 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 525381005947 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 525381005948 YcfA-like protein; Region: YcfA; pfam07927 525381005949 recombination factor protein RarA; Reviewed; Region: PRK13342 525381005950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381005951 Walker A motif; other site 525381005952 ATP binding site [chemical binding]; other site 525381005953 Walker B motif; other site 525381005954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 525381005955 arginine finger; other site 525381005956 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 525381005957 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 525381005958 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 525381005959 substrate binding [chemical binding]; other site 525381005960 active site 525381005961 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 525381005962 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525381005963 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525381005964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381005965 dimer interface [polypeptide binding]; other site 525381005966 conserved gate region; other site 525381005967 ABC-ATPase subunit interface; other site 525381005968 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 525381005969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381005970 dimer interface [polypeptide binding]; other site 525381005971 conserved gate region; other site 525381005972 putative PBP binding loops; other site 525381005973 ABC-ATPase subunit interface; other site 525381005974 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525381005975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525381005976 DNA binding site [nucleotide binding] 525381005977 domain linker motif; other site 525381005978 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 525381005979 dimerization interface [polypeptide binding]; other site 525381005980 ligand binding site [chemical binding]; other site 525381005981 sodium binding site [ion binding]; other site 525381005982 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 525381005983 Mga helix-turn-helix domain; Region: Mga; pfam05043 525381005984 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 525381005985 Predicted membrane protein [Function unknown]; Region: COG2261 525381005986 Small integral membrane protein [Function unknown]; Region: COG5547 525381005987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 525381005988 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 525381005989 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525381005990 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525381005991 Coenzyme A binding pocket [chemical binding]; other site 525381005992 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 525381005993 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 525381005994 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 525381005995 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525381005996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381005997 non-specific DNA binding site [nucleotide binding]; other site 525381005998 salt bridge; other site 525381005999 sequence-specific DNA binding site [nucleotide binding]; other site 525381006000 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 525381006001 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 525381006002 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 525381006003 substrate binding site [chemical binding]; other site 525381006004 active site 525381006005 catalytic residues [active] 525381006006 heterodimer interface [polypeptide binding]; other site 525381006007 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 525381006008 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 525381006009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381006010 catalytic residue [active] 525381006011 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 525381006012 active site 525381006013 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 525381006014 active site 525381006015 ribulose/triose binding site [chemical binding]; other site 525381006016 phosphate binding site [ion binding]; other site 525381006017 substrate (anthranilate) binding pocket [chemical binding]; other site 525381006018 product (indole) binding pocket [chemical binding]; other site 525381006019 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 525381006020 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 525381006021 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 525381006022 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 525381006023 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 525381006024 glutamine binding [chemical binding]; other site 525381006025 catalytic triad [active] 525381006026 anthranilate synthase component I; Provisional; Region: PRK13570 525381006027 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 525381006028 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 525381006029 T-box leader; HMPREF0837_nc10027 525381006030 T-box leader; HMPREF0837_nc10028 525381006031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525381006032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525381006033 DNA binding site [nucleotide binding] 525381006034 domain linker motif; other site 525381006035 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 525381006036 putative dimerization interface [polypeptide binding]; other site 525381006037 putative ligand binding site [chemical binding]; other site 525381006038 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 525381006039 MgtC family; Region: MgtC; pfam02308 525381006040 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 525381006041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381006042 dimer interface [polypeptide binding]; other site 525381006043 conserved gate region; other site 525381006044 putative PBP binding loops; other site 525381006045 ABC-ATPase subunit interface; other site 525381006046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381006047 putative PBP binding loops; other site 525381006048 dimer interface [polypeptide binding]; other site 525381006049 ABC-ATPase subunit interface; other site 525381006050 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525381006051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381006052 Walker A/P-loop; other site 525381006053 ATP binding site [chemical binding]; other site 525381006054 Q-loop/lid; other site 525381006055 ABC transporter signature motif; other site 525381006056 Walker B; other site 525381006057 D-loop; other site 525381006058 H-loop/switch region; other site 525381006059 TOBE domain; Region: TOBE_2; pfam08402 525381006060 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 525381006061 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525381006062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 525381006063 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 525381006064 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 525381006065 UDP-glucose 4-epimerase; Region: PLN02240 525381006066 NAD binding site [chemical binding]; other site 525381006067 homodimer interface [polypeptide binding]; other site 525381006068 active site 525381006069 substrate binding site [chemical binding]; other site 525381006070 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 525381006071 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 525381006072 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 525381006073 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 525381006074 PhoU domain; Region: PhoU; pfam01895 525381006075 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 525381006076 active site 525381006077 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 525381006078 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 525381006079 Pectate lyase; Region: Pec_lyase_C; cl01593 525381006080 Right handed beta helix region; Region: Beta_helix; pfam13229 525381006081 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 525381006082 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 525381006083 inhibitor-cofactor binding pocket; inhibition site 525381006084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381006085 catalytic residue [active] 525381006086 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 525381006087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525381006088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381006089 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 525381006090 Walker A/P-loop; other site 525381006091 ATP binding site [chemical binding]; other site 525381006092 Q-loop/lid; other site 525381006093 ABC transporter signature motif; other site 525381006094 Walker B; other site 525381006095 D-loop; other site 525381006096 H-loop/switch region; other site 525381006097 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525381006098 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381006099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381006100 Walker A/P-loop; other site 525381006101 ATP binding site [chemical binding]; other site 525381006102 Q-loop/lid; other site 525381006103 ABC transporter signature motif; other site 525381006104 Walker B; other site 525381006105 D-loop; other site 525381006106 H-loop/switch region; other site 525381006107 Predicted membrane protein [Function unknown]; Region: COG2323 525381006108 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 525381006109 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 525381006110 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 525381006111 active site 525381006112 putative catalytic site [active] 525381006113 DNA binding site [nucleotide binding] 525381006114 putative phosphate binding site [ion binding]; other site 525381006115 metal binding site A [ion binding]; metal-binding site 525381006116 AP binding site [nucleotide binding]; other site 525381006117 metal binding site B [ion binding]; metal-binding site 525381006118 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 525381006119 dimer interface [polypeptide binding]; other site 525381006120 ligand binding site [chemical binding]; other site 525381006121 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 525381006122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381006123 active site 525381006124 xanthine permease; Region: pbuX; TIGR03173 525381006125 Sulfate transporter family; Region: Sulfate_transp; pfam00916 525381006126 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 525381006127 Dam-replacing family; Region: DRP; pfam06044 525381006128 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 525381006129 CoenzymeA binding site [chemical binding]; other site 525381006130 subunit interaction site [polypeptide binding]; other site 525381006131 PHB binding site; other site 525381006132 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 525381006133 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 525381006134 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 525381006135 galactokinase; Provisional; Region: PRK05322 525381006136 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 525381006137 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 525381006138 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 525381006139 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 525381006140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525381006141 DNA binding site [nucleotide binding] 525381006142 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 525381006143 putative dimerization interface [polypeptide binding]; other site 525381006144 putative ligand binding site [chemical binding]; other site 525381006145 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 525381006146 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 525381006147 catalytic Zn binding site [ion binding]; other site 525381006148 NAD(P) binding site [chemical binding]; other site 525381006149 structural Zn binding site [ion binding]; other site 525381006150 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 525381006151 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 525381006152 DNA binding residues [nucleotide binding] 525381006153 putative dimer interface [polypeptide binding]; other site 525381006154 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 525381006155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525381006156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525381006157 Utp21 specific WD40 associated putative domain; Region: Utp21; pfam04192 525381006158 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 525381006159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381006160 dimer interface [polypeptide binding]; other site 525381006161 conserved gate region; other site 525381006162 ABC-ATPase subunit interface; other site 525381006163 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 525381006164 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 525381006165 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525381006166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381006167 Walker A/P-loop; other site 525381006168 ATP binding site [chemical binding]; other site 525381006169 Q-loop/lid; other site 525381006170 ABC transporter signature motif; other site 525381006171 Walker B; other site 525381006172 D-loop; other site 525381006173 H-loop/switch region; other site 525381006174 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 525381006175 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 525381006176 MarR family; Region: MarR_2; cl17246 525381006177 Enterocin A Immunity; Region: EntA_Immun; pfam08951 525381006178 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 525381006179 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 525381006180 oligomer interface [polypeptide binding]; other site 525381006181 active site 525381006182 metal binding site [ion binding]; metal-binding site 525381006183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525381006184 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 525381006185 NAD(P) binding site [chemical binding]; other site 525381006186 active site 525381006187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525381006188 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 525381006189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525381006190 ABC-ATPase subunit interface; other site 525381006191 dimer interface [polypeptide binding]; other site 525381006192 putative PBP binding regions; other site 525381006193 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525381006194 ABC-ATPase subunit interface; other site 525381006195 dimer interface [polypeptide binding]; other site 525381006196 putative PBP binding regions; other site 525381006197 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 525381006198 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 525381006199 Walker A/P-loop; other site 525381006200 ATP binding site [chemical binding]; other site 525381006201 Q-loop/lid; other site 525381006202 ABC transporter signature motif; other site 525381006203 Walker B; other site 525381006204 D-loop; other site 525381006205 H-loop/switch region; other site 525381006206 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 525381006207 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 525381006208 putative ligand binding residues [chemical binding]; other site 525381006209 hypothetical protein; Validated; Region: PRK00041 525381006210 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 525381006211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525381006212 RNA binding surface [nucleotide binding]; other site 525381006213 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 525381006214 active site 525381006215 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 525381006216 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 525381006217 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 525381006218 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525381006219 DNA binding site [nucleotide binding] 525381006220 Int/Topo IB signature motif; other site 525381006221 active site 525381006222 catalytic residues [active] 525381006223 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 525381006224 FOG: CBS domain [General function prediction only]; Region: COG0517 525381006225 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 525381006226 active site 525381006227 metal binding site [ion binding]; metal-binding site 525381006228 homotetramer interface [polypeptide binding]; other site 525381006229 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 525381006230 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 525381006231 active site 525381006232 dimerization interface [polypeptide binding]; other site 525381006233 glutamate racemase; Provisional; Region: PRK00865 525381006234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 525381006235 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 525381006236 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 525381006237 Ca binding site [ion binding]; other site 525381006238 active site 525381006239 catalytic site [active] 525381006240 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 525381006241 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 525381006242 active site turn [active] 525381006243 phosphorylation site [posttranslational modification] 525381006244 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 525381006245 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 525381006246 HPr interaction site; other site 525381006247 glycerol kinase (GK) interaction site [polypeptide binding]; other site 525381006248 active site 525381006249 phosphorylation site [posttranslational modification] 525381006250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525381006251 DNA-binding site [nucleotide binding]; DNA binding site 525381006252 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 525381006253 UTRA domain; Region: UTRA; pfam07702 525381006254 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525381006255 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381006256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381006257 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381006258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381006259 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 525381006260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381006261 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381006262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 525381006263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525381006264 Walker A/P-loop; other site 525381006265 ATP binding site [chemical binding]; other site 525381006266 Q-loop/lid; other site 525381006267 ABC transporter signature motif; other site 525381006268 Walker B; other site 525381006269 D-loop; other site 525381006270 H-loop/switch region; other site 525381006271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 525381006272 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525381006273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525381006274 Walker A/P-loop; other site 525381006275 ATP binding site [chemical binding]; other site 525381006276 Q-loop/lid; other site 525381006277 ABC transporter signature motif; other site 525381006278 Walker B; other site 525381006279 D-loop; other site 525381006280 H-loop/switch region; other site 525381006281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525381006282 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 525381006283 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 525381006284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381006285 dimer interface [polypeptide binding]; other site 525381006286 conserved gate region; other site 525381006287 putative PBP binding loops; other site 525381006288 ABC-ATPase subunit interface; other site 525381006289 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525381006290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381006291 dimer interface [polypeptide binding]; other site 525381006292 conserved gate region; other site 525381006293 putative PBP binding loops; other site 525381006294 ABC-ATPase subunit interface; other site 525381006295 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 525381006296 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 525381006297 peptide binding site [polypeptide binding]; other site 525381006298 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 525381006299 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 525381006300 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 525381006301 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 525381006302 active site 525381006303 homodimer interface [polypeptide binding]; other site 525381006304 catalytic site [active] 525381006305 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525381006306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381006307 dimer interface [polypeptide binding]; other site 525381006308 conserved gate region; other site 525381006309 putative PBP binding loops; other site 525381006310 ABC-ATPase subunit interface; other site 525381006311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381006312 dimer interface [polypeptide binding]; other site 525381006313 conserved gate region; other site 525381006314 putative PBP binding loops; other site 525381006315 ABC-ATPase subunit interface; other site 525381006316 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525381006317 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 525381006318 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 525381006319 Melibiase; Region: Melibiase; pfam02065 525381006320 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 525381006321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525381006322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 525381006323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525381006324 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 525381006325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525381006326 DNA-binding site [nucleotide binding]; DNA binding site 525381006327 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 525381006328 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 525381006329 TRAM domain; Region: TRAM; pfam01938 525381006330 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 525381006331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381006332 S-adenosylmethionine binding site [chemical binding]; other site 525381006333 recombination regulator RecX; Provisional; Region: recX; PRK14135 525381006334 hypothetical protein; Provisional; Region: PRK13662 525381006335 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 525381006336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381006337 non-specific DNA binding site [nucleotide binding]; other site 525381006338 salt bridge; other site 525381006339 sequence-specific DNA binding site [nucleotide binding]; other site 525381006340 Methyltransferase domain; Region: Methyltransf_31; pfam13847 525381006341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381006342 S-adenosylmethionine binding site [chemical binding]; other site 525381006343 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 525381006344 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 525381006345 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 525381006346 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 525381006347 ring oligomerisation interface [polypeptide binding]; other site 525381006348 ATP/Mg binding site [chemical binding]; other site 525381006349 stacking interactions; other site 525381006350 hinge regions; other site 525381006351 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 525381006352 oligomerisation interface [polypeptide binding]; other site 525381006353 mobile loop; other site 525381006354 roof hairpin; other site 525381006355 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 525381006356 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 525381006357 dimer interface [polypeptide binding]; other site 525381006358 ssDNA binding site [nucleotide binding]; other site 525381006359 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525381006360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525381006361 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 525381006362 NAD(P) binding site [chemical binding]; other site 525381006363 active site 525381006364 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 525381006365 putative tRNA-binding site [nucleotide binding]; other site 525381006366 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525381006367 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525381006368 catalytic residues [active] 525381006369 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381006370 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 525381006371 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 525381006372 LytTr DNA-binding domain; Region: LytTR; pfam04397 525381006373 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 525381006374 active site 525381006375 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 525381006376 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 525381006377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381006378 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525381006379 Walker A/P-loop; other site 525381006380 ATP binding site [chemical binding]; other site 525381006381 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 525381006382 Walker A/P-loop; other site 525381006383 ATP binding site [chemical binding]; other site 525381006384 Q-loop/lid; other site 525381006385 ABC transporter signature motif; other site 525381006386 Walker B; other site 525381006387 D-loop; other site 525381006388 H-loop/switch region; other site 525381006389 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525381006390 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525381006391 MarR family; Region: MarR_2; pfam12802 525381006392 Transcriptional regulators [Transcription]; Region: MarR; COG1846 525381006393 hypothetical protein; Provisional; Region: PRK12378 525381006394 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 525381006395 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 525381006396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 525381006397 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 525381006398 putative active site [active] 525381006399 catalytic site [active] 525381006400 putative metal binding site [ion binding]; other site 525381006401 oligomer interface [polypeptide binding]; other site 525381006402 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525381006403 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 525381006404 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525381006405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525381006406 Walker A/P-loop; other site 525381006407 ATP binding site [chemical binding]; other site 525381006408 Q-loop/lid; other site 525381006409 ABC transporter signature motif; other site 525381006410 Walker B; other site 525381006411 D-loop; other site 525381006412 H-loop/switch region; other site 525381006413 TOBE domain; Region: TOBE_2; pfam08402 525381006414 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 525381006415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381006416 dimer interface [polypeptide binding]; other site 525381006417 conserved gate region; other site 525381006418 putative PBP binding loops; other site 525381006419 ABC-ATPase subunit interface; other site 525381006420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525381006421 dimer interface [polypeptide binding]; other site 525381006422 conserved gate region; other site 525381006423 putative PBP binding loops; other site 525381006424 ABC-ATPase subunit interface; other site 525381006425 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 525381006426 MgtC family; Region: MgtC; pfam02308 525381006427 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 525381006428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381006429 motif II; other site 525381006430 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525381006431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525381006432 DNA binding site [nucleotide binding] 525381006433 domain linker motif; other site 525381006434 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525381006435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 525381006436 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 525381006437 Domain of unknown function (DUF955); Region: DUF955; cl01076 525381006438 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525381006439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381006440 non-specific DNA binding site [nucleotide binding]; other site 525381006441 salt bridge; other site 525381006442 sequence-specific DNA binding site [nucleotide binding]; other site 525381006443 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525381006444 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 525381006445 amidase catalytic site [active] 525381006446 Zn binding residues [ion binding]; other site 525381006447 substrate binding site [chemical binding]; other site 525381006448 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381006449 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 525381006450 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525381006451 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 525381006452 recombinase A; Provisional; Region: recA; PRK09354 525381006453 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 525381006454 hexamer interface [polypeptide binding]; other site 525381006455 Walker A motif; other site 525381006456 ATP binding site [chemical binding]; other site 525381006457 Walker B motif; other site 525381006458 competence damage-inducible protein A; Provisional; Region: PRK00549 525381006459 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 525381006460 putative MPT binding site; other site 525381006461 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 525381006462 Transcriptional regulator [Transcription]; Region: LytR; COG1316 525381006463 putative acetyltransferase YhhY; Provisional; Region: PRK10140 525381006464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525381006465 Coenzyme A binding pocket [chemical binding]; other site 525381006466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 525381006467 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 525381006468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525381006469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381006470 non-specific DNA binding site [nucleotide binding]; other site 525381006471 salt bridge; other site 525381006472 sequence-specific DNA binding site [nucleotide binding]; other site 525381006473 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 525381006474 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 525381006475 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 525381006476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525381006477 Walker A motif; other site 525381006478 ATP binding site [chemical binding]; other site 525381006479 Walker B motif; other site 525381006480 arginine finger; other site 525381006481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381006482 non-specific DNA binding site [nucleotide binding]; other site 525381006483 salt bridge; other site 525381006484 sequence-specific DNA binding site [nucleotide binding]; other site 525381006485 Replication initiation factor; Region: Rep_trans; pfam02486 525381006486 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 525381006487 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 525381006488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381006489 S-adenosylmethionine binding site [chemical binding]; other site 525381006490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 525381006491 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525381006492 Antirestriction protein (ArdA); Region: ArdA; pfam07275 525381006493 TcpE family; Region: TcpE; pfam12648 525381006494 AAA-like domain; Region: AAA_10; pfam12846 525381006495 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 525381006496 Haemolysin-III related; Region: HlyIII; cl03831 525381006497 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525381006498 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525381006499 catalytic residue [active] 525381006500 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 525381006501 NlpC/P60 family; Region: NLPC_P60; pfam00877 525381006502 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 525381006503 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 525381006504 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 525381006505 G1 box; other site 525381006506 putative GEF interaction site [polypeptide binding]; other site 525381006507 GTP/Mg2+ binding site [chemical binding]; other site 525381006508 Switch I region; other site 525381006509 G2 box; other site 525381006510 G3 box; other site 525381006511 Switch II region; other site 525381006512 G4 box; other site 525381006513 G5 box; other site 525381006514 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 525381006515 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 525381006516 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 525381006517 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 525381006518 impB/mucB/samB family C-terminal; Region: IMS_C; pfam11799 525381006519 YolD-like protein; Region: YolD; pfam08863 525381006520 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525381006521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381006522 ABC transporter; Region: ABC_tran_2; pfam12848 525381006523 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525381006524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525381006525 H+ Antiporter protein; Region: 2A0121; TIGR00900 525381006526 putative substrate translocation pore; other site 525381006527 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 525381006528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381006529 non-specific DNA binding site [nucleotide binding]; other site 525381006530 salt bridge; other site 525381006531 sequence-specific DNA binding site [nucleotide binding]; other site 525381006532 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 525381006533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525381006534 DNA binding residues [nucleotide binding] 525381006535 Helix-turn-helix domain; Region: HTH_16; pfam12645 525381006536 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 525381006537 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 525381006538 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 525381006539 Int/Topo IB signature motif; other site 525381006540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 525381006541 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 525381006542 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525381006543 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 525381006544 Walker A/P-loop; other site 525381006545 ATP binding site [chemical binding]; other site 525381006546 Q-loop/lid; other site 525381006547 ABC transporter signature motif; other site 525381006548 Walker B; other site 525381006549 D-loop; other site 525381006550 H-loop/switch region; other site 525381006551 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 525381006552 active site 525381006553 multimer interface [polypeptide binding]; other site 525381006554 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 525381006555 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 525381006556 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 525381006557 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 525381006558 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 525381006559 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 525381006560 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 525381006561 G-loop; other site 525381006562 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 525381006563 DNA binding site [nucleotide binding] 525381006564 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 525381006565 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 525381006566 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 525381006567 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 525381006568 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 525381006569 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 525381006570 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 525381006571 RPB1 interaction site [polypeptide binding]; other site 525381006572 RPB10 interaction site [polypeptide binding]; other site 525381006573 RPB11 interaction site [polypeptide binding]; other site 525381006574 RPB3 interaction site [polypeptide binding]; other site 525381006575 RPB12 interaction site [polypeptide binding]; other site 525381006576 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 525381006577 Domain of unknown function DUF21; Region: DUF21; pfam01595 525381006578 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525381006579 Transporter associated domain; Region: CorC_HlyC; smart01091 525381006580 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 525381006581 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 525381006582 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 525381006583 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 525381006584 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 525381006585 hinge; other site 525381006586 active site 525381006587 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 525381006588 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 525381006589 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 525381006590 protein binding site [polypeptide binding]; other site 525381006591 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525381006592 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 525381006593 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 525381006594 active site 525381006595 (T/H)XGH motif; other site 525381006596 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 525381006597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381006598 S-adenosylmethionine binding site [chemical binding]; other site 525381006599 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 525381006600 dimer interface [polypeptide binding]; other site 525381006601 active site 525381006602 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 525381006603 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 525381006604 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 525381006605 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 525381006606 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 525381006607 acylphosphatase; Provisional; Region: PRK14434 525381006608 OxaA-like protein precursor; Provisional; Region: PRK02463 525381006609 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 525381006610 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 525381006611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525381006612 FeS/SAM binding site; other site 525381006613 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 525381006614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 525381006615 active site 525381006616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525381006617 substrate binding site [chemical binding]; other site 525381006618 catalytic residues [active] 525381006619 dimer interface [polypeptide binding]; other site 525381006620 pur operon repressor; Provisional; Region: PRK09213 525381006621 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 525381006622 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525381006623 active site 525381006624 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 525381006625 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 525381006626 generic binding surface II; other site 525381006627 generic binding surface I; other site 525381006628 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525381006629 Zn2+ binding site [ion binding]; other site 525381006630 Mg2+ binding site [ion binding]; other site 525381006631 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 525381006632 RmuC family; Region: RmuC; pfam02646 525381006633 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 525381006634 Thiamine pyrophosphokinase; Region: TPK; cd07995 525381006635 active site 525381006636 dimerization interface [polypeptide binding]; other site 525381006637 thiamine binding site [chemical binding]; other site 525381006638 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 525381006639 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 525381006640 substrate binding site [chemical binding]; other site 525381006641 hexamer interface [polypeptide binding]; other site 525381006642 metal binding site [ion binding]; metal-binding site 525381006643 GTPase RsgA; Reviewed; Region: PRK00098 525381006644 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 525381006645 RNA binding site [nucleotide binding]; other site 525381006646 homodimer interface [polypeptide binding]; other site 525381006647 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 525381006648 GTPase/Zn-binding domain interface [polypeptide binding]; other site 525381006649 GTP/Mg2+ binding site [chemical binding]; other site 525381006650 G4 box; other site 525381006651 G5 box; other site 525381006652 G1 box; other site 525381006653 Switch I region; other site 525381006654 G2 box; other site 525381006655 G3 box; other site 525381006656 Switch II region; other site 525381006657 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 525381006658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525381006659 S-adenosylmethionine binding site [chemical binding]; other site 525381006660 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525381006661 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 525381006662 Walker A/P-loop; other site 525381006663 ATP binding site [chemical binding]; other site 525381006664 Q-loop/lid; other site 525381006665 ABC transporter signature motif; other site 525381006666 Walker B; other site 525381006667 D-loop; other site 525381006668 H-loop/switch region; other site 525381006669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 525381006670 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 525381006671 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525381006672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525381006673 non-specific DNA binding site [nucleotide binding]; other site 525381006674 salt bridge; other site 525381006675 sequence-specific DNA binding site [nucleotide binding]; other site 525381006676 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 525381006677 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 525381006678 putative active site [active] 525381006679 putative metal binding site [ion binding]; other site 525381006680 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 525381006681 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 525381006682 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 525381006683 active site 525381006684 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 525381006685 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 525381006686 aminotransferase AlaT; Validated; Region: PRK09265 525381006687 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525381006688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525381006689 homodimer interface [polypeptide binding]; other site 525381006690 catalytic residue [active] 525381006691 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525381006692 Ligand Binding Site [chemical binding]; other site 525381006693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381006694 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525381006695 active site 525381006696 motif I; other site 525381006697 motif II; other site 525381006698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525381006699 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 525381006700 putative nucleotide binding site [chemical binding]; other site 525381006701 putative metal binding site [ion binding]; other site 525381006702 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 525381006703 active site 525381006704 homotetramer interface [polypeptide binding]; other site 525381006705 homodimer interface [polypeptide binding]; other site 525381006706 catabolite control protein A; Region: ccpA; TIGR01481 525381006707 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525381006708 DNA binding site [nucleotide binding] 525381006709 domain linker motif; other site 525381006710 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 525381006711 dimerization interface [polypeptide binding]; other site 525381006712 effector binding site; other site 525381006713 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525381006714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525381006715 active site 525381006716 phosphorylation site [posttranslational modification] 525381006717 intermolecular recognition site; other site 525381006718 dimerization interface [polypeptide binding]; other site 525381006719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525381006720 DNA binding residues [nucleotide binding] 525381006721 dimerization interface [polypeptide binding]; other site 525381006722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 525381006723 Histidine kinase; Region: HisKA_3; pfam07730 525381006724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525381006725 Mg2+ binding site [ion binding]; other site 525381006726 G-X-G motif; other site 525381006727 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 525381006728 ABC-2 type transporter; Region: ABC2_membrane; cl17235 525381006729 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 525381006730 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525381006731 Walker A/P-loop; other site 525381006732 ATP binding site [chemical binding]; other site 525381006733 Q-loop/lid; other site 525381006734 ABC transporter signature motif; other site 525381006735 Walker B; other site 525381006736 D-loop; other site 525381006737 H-loop/switch region; other site 525381006738 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701