-- dump date 20140620_085026 -- class Genbank::misc_feature -- table misc_feature_note -- id note 869303000001 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 869303000002 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869303000003 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 869303000004 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869303000005 dimer interface [polypeptide binding]; other site 869303000006 active site 869303000007 catalytic residue [active] 869303000008 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 869303000009 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 869303000010 trmE is a tRNA modification GTPase; Region: trmE; cd04164 869303000011 G1 box; other site 869303000012 GTP/Mg2+ binding site [chemical binding]; other site 869303000013 Switch I region; other site 869303000014 G2 box; other site 869303000015 Switch II region; other site 869303000016 G3 box; other site 869303000017 G4 box; other site 869303000018 G5 box; other site 869303000019 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 869303000020 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 869303000021 active site 1 [active] 869303000022 dimer interface [polypeptide binding]; other site 869303000023 hexamer interface [polypeptide binding]; other site 869303000024 active site 2 [active] 869303000025 thymidine kinase; Provisional; Region: PRK04296 869303000026 peptide chain release factor 1; Validated; Region: prfA; PRK00591 869303000027 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869303000028 RF-1 domain; Region: RF-1; pfam00472 869303000029 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 869303000030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303000031 S-adenosylmethionine binding site [chemical binding]; other site 869303000032 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 869303000033 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869303000034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303000035 Coenzyme A binding pocket [chemical binding]; other site 869303000036 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 869303000037 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 869303000038 dimer interface [polypeptide binding]; other site 869303000039 active site 869303000040 glycine-pyridoxal phosphate binding site [chemical binding]; other site 869303000041 folate binding site [chemical binding]; other site 869303000042 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 869303000043 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 869303000044 Lysozyme-like; Region: Lysozyme_like; pfam13702 869303000045 Predicted secreted protein [Function unknown]; Region: COG4086 869303000046 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 869303000047 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869303000048 TRAM domain; Region: TRAM; cl01282 869303000049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303000050 S-adenosylmethionine binding site [chemical binding]; other site 869303000051 Predicted transcriptional regulator [Transcription]; Region: COG3655 869303000052 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869303000053 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869303000054 siderophore binding site; other site 869303000055 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 869303000056 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869303000057 ABC-ATPase subunit interface; other site 869303000058 dimer interface [polypeptide binding]; other site 869303000059 putative PBP binding regions; other site 869303000060 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869303000061 ABC-ATPase subunit interface; other site 869303000062 dimer interface [polypeptide binding]; other site 869303000063 putative PBP binding regions; other site 869303000064 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869303000065 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869303000066 Walker A/P-loop; other site 869303000067 ATP binding site [chemical binding]; other site 869303000068 Q-loop/lid; other site 869303000069 ABC transporter signature motif; other site 869303000070 Walker B; other site 869303000071 D-loop; other site 869303000072 H-loop/switch region; other site 869303000074 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 869303000076 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 869303000077 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 869303000078 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 869303000079 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 869303000080 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 869303000081 homodimer interface [polypeptide binding]; other site 869303000082 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 869303000083 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 869303000084 active site 869303000085 homodimer interface [polypeptide binding]; other site 869303000086 catalytic site [active] 869303000087 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869303000088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303000089 non-specific DNA binding site [nucleotide binding]; other site 869303000090 salt bridge; other site 869303000091 sequence-specific DNA binding site [nucleotide binding]; other site 869303000092 Zeta toxin; Region: Zeta_toxin; pfam06414 869303000093 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869303000094 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 869303000095 AAA domain; Region: AAA_21; pfam13304 869303000096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303000097 ABC transporter signature motif; other site 869303000098 Walker B; other site 869303000099 D-loop; other site 869303000100 H-loop/switch region; other site 869303000101 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 869303000103 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 869303000104 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869303000105 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869303000106 Enolase [Carbohydrate transport and metabolism]; Region: Eno; COG0148 869303000107 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 869303000108 metal binding site [ion binding]; metal-binding site 869303000109 substrate binding pocket [chemical binding]; other site 869303000110 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869303000111 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 869303000112 homodimer interface [polypeptide binding]; other site 869303000113 substrate-cofactor binding pocket; other site 869303000114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303000115 catalytic residue [active] 869303000116 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869303000117 TPP-binding site [chemical binding]; other site 869303000118 dimer interface [polypeptide binding]; other site 869303000119 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 869303000120 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869303000121 PYR/PP interface [polypeptide binding]; other site 869303000122 dimer interface [polypeptide binding]; other site 869303000123 TPP binding site [chemical binding]; other site 869303000124 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869303000125 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 869303000126 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869303000127 inhibitor-cofactor binding pocket; inhibition site 869303000128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303000129 catalytic residue [active] 869303000130 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 869303000131 active site 869303000132 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 869303000133 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 869303000134 active site 869303000135 catalytic residues [active] 869303000136 metal binding site [ion binding]; metal-binding site 869303000137 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 869303000138 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 869303000139 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 869303000140 tetramer interface [polypeptide binding]; other site 869303000141 active site 869303000142 Mg2+/Mn2+ binding site [ion binding]; other site 869303000143 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869303000144 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 869303000145 PYR/PP interface [polypeptide binding]; other site 869303000146 dimer interface [polypeptide binding]; other site 869303000147 TPP binding site [chemical binding]; other site 869303000148 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 869303000149 TPP-binding site [chemical binding]; other site 869303000150 hypothetical protein; Validated; Region: PRK07080 869303000151 acyl carrier protein; Provisional; Region: PRK07081 869303000152 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 869303000153 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 869303000154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303000155 Walker A/P-loop; other site 869303000156 ATP binding site [chemical binding]; other site 869303000157 Q-loop/lid; other site 869303000158 ABC transporter signature motif; other site 869303000159 Walker B; other site 869303000160 D-loop; other site 869303000161 H-loop/switch region; other site 869303000162 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869303000163 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 869303000164 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 869303000167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869303000168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303000169 non-specific DNA binding site [nucleotide binding]; other site 869303000170 salt bridge; other site 869303000171 sequence-specific DNA binding site [nucleotide binding]; other site 869303000173 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 869303000174 conserved cys residue [active] 869303000175 Phosphotransferase enzyme family; Region: APH; pfam01636 869303000176 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 869303000177 active site 869303000178 ATP binding site [chemical binding]; other site 869303000179 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 869303000180 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 869303000181 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 869303000182 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 869303000183 zinc binding site [ion binding]; other site 869303000184 putative ligand binding site [chemical binding]; other site 869303000185 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869303000186 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 869303000187 TM-ABC transporter signature motif; other site 869303000188 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 869303000189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303000190 Walker A/P-loop; other site 869303000191 ATP binding site [chemical binding]; other site 869303000192 Q-loop/lid; other site 869303000193 ABC transporter signature motif; other site 869303000194 Walker B; other site 869303000195 D-loop; other site 869303000196 H-loop/switch region; other site 869303000197 DNA primase; Validated; Region: dnaG; PRK05667 869303000198 CHC2 zinc finger; Region: zf-CHC2; pfam01807 869303000199 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 869303000200 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 869303000201 active site 869303000202 metal binding site [ion binding]; metal-binding site 869303000203 interdomain interaction site; other site 869303000204 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 869303000205 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 869303000206 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869303000207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869303000208 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869303000209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869303000210 DNA binding residues [nucleotide binding] 869303000211 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869303000212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869303000213 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 869303000214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869303000215 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 869303000216 putative ADP-binding pocket [chemical binding]; other site 869303000217 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 869303000218 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 869303000219 GTPase CgtA; Reviewed; Region: obgE; PRK12297 869303000220 GTP1/OBG; Region: GTP1_OBG; pfam01018 869303000221 Obg GTPase; Region: Obg; cd01898 869303000222 G1 box; other site 869303000223 GTP/Mg2+ binding site [chemical binding]; other site 869303000224 Switch I region; other site 869303000225 G2 box; other site 869303000226 G3 box; other site 869303000227 Switch II region; other site 869303000228 G4 box; other site 869303000229 G5 box; other site 869303000230 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 869303000231 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869303000232 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869303000233 hinge; other site 869303000234 active site 869303000235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869303000236 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869303000237 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 869303000238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869303000239 DNA-binding site [nucleotide binding]; DNA binding site 869303000240 DRTGG domain; Region: DRTGG; pfam07085 869303000241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 869303000242 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 869303000243 active site 2 [active] 869303000244 active site 1 [active] 869303000245 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 869303000246 active site 869303000248 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 869303000249 Part of AAA domain; Region: AAA_19; pfam13245 869303000250 Family description; Region: UvrD_C_2; pfam13538 869303000251 hypothetical protein; Reviewed; Region: PRK00024 869303000252 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869303000253 MPN+ (JAMM) motif; other site 869303000254 Zinc-binding site [ion binding]; other site 869303000255 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 869303000256 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 869303000257 catalytic triad [active] 869303000258 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 869303000259 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 869303000260 CoA binding domain; Region: CoA_binding; pfam02629 869303000261 Putative amino acid metabolism; Region: DUF1831; pfam08866 869303000262 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869303000263 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869303000264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869303000265 catalytic residue [active] 869303000266 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 869303000267 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869303000268 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303000269 active site 869303000270 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 869303000271 putative active site [active] 869303000272 putative metal binding residues [ion binding]; other site 869303000273 signature motif; other site 869303000274 putative triphosphate binding site [ion binding]; other site 869303000275 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869303000276 synthetase active site [active] 869303000277 NTP binding site [chemical binding]; other site 869303000278 metal binding site [ion binding]; metal-binding site 869303000279 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 869303000280 ATP-NAD kinase; Region: NAD_kinase; pfam01513 869303000281 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869303000282 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 869303000283 RNA binding surface [nucleotide binding]; other site 869303000284 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869303000285 active site 869303000286 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 869303000288 hypothetical protein; Validated; Region: PRK00153 869303000290 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 869303000291 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 869303000292 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 869303000293 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 869303000294 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 869303000295 active site 869303000296 Riboflavin kinase; Region: Flavokinase; smart00904 869303000297 Uncharacterized conserved protein [Function unknown]; Region: COG1284 869303000298 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869303000299 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869303000300 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869303000301 EDD domain protein, DegV family; Region: DegV; TIGR00762 869303000302 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869303000303 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869303000304 IHF dimer interface [polypeptide binding]; other site 869303000305 IHF - DNA interface [nucleotide binding]; other site 869303000306 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869303000307 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303000308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303000309 ABC transporter; Region: ABC_tran_2; pfam12848 869303000310 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303000311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303000312 non-specific DNA binding site [nucleotide binding]; other site 869303000313 salt bridge; other site 869303000314 sequence-specific DNA binding site [nucleotide binding]; other site 869303000315 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869303000316 H+ Antiporter protein; Region: 2A0121; TIGR00900 869303000317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869303000318 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 869303000319 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 869303000320 nucleotide binding pocket [chemical binding]; other site 869303000321 K-X-D-G motif; other site 869303000322 catalytic site [active] 869303000323 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 869303000324 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 869303000325 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 869303000326 Dimer interface [polypeptide binding]; other site 869303000327 BRCT sequence motif; other site 869303000328 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 869303000329 pullulanase, type I; Region: pulA_typeI; TIGR02104 869303000330 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 869303000331 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 869303000332 Ca binding site [ion binding]; other site 869303000333 active site 869303000334 catalytic site [active] 869303000335 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 869303000336 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 869303000337 tetrameric interface [polypeptide binding]; other site 869303000338 activator binding site; other site 869303000339 NADP binding site [chemical binding]; other site 869303000340 substrate binding site [chemical binding]; other site 869303000341 catalytic residues [active] 869303000342 glycogen branching enzyme; Provisional; Region: PRK12313 869303000343 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 869303000344 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 869303000345 active site 869303000346 catalytic site [active] 869303000347 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 869303000348 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 869303000349 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 869303000350 ligand binding site; other site 869303000351 oligomer interface; other site 869303000352 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869303000353 dimer interface [polypeptide binding]; other site 869303000354 N-terminal domain interface [polypeptide binding]; other site 869303000355 sulfate 1 binding site; other site 869303000356 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 869303000357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869303000358 active site 869303000359 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869303000360 dimer interface [polypeptide binding]; other site 869303000361 N-terminal domain interface [polypeptide binding]; other site 869303000362 sulfate 1 binding site; other site 869303000363 glycogen synthase; Provisional; Region: glgA; PRK00654 869303000364 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 869303000365 ADP-binding pocket [chemical binding]; other site 869303000366 homodimer interface [polypeptide binding]; other site 869303000368 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 869303000369 Uncharacterized conserved protein [Function unknown]; Region: COG5506 869303000370 enolase; Provisional; Region: eno; PRK00077 869303000371 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 869303000372 dimer interface [polypeptide binding]; other site 869303000373 metal binding site [ion binding]; metal-binding site 869303000374 substrate binding pocket [chemical binding]; other site 869303000377 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 869303000378 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869303000379 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 869303000380 Part of AAA domain; Region: AAA_19; pfam13245 869303000381 Family description; Region: UvrD_C_2; pfam13538 869303000382 Family description; Region: UvrD_C_2; pfam13538 869303000383 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869303000384 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869303000385 G5 domain; Region: G5; pfam07501 869303000386 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 869303000387 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 869303000388 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 869303000389 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 869303000390 GTP/Mg2+ binding site [chemical binding]; other site 869303000391 G4 box; other site 869303000392 G5 box; other site 869303000393 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869303000394 G1 box; other site 869303000395 G1 box; other site 869303000396 GTP/Mg2+ binding site [chemical binding]; other site 869303000397 Switch I region; other site 869303000398 G2 box; other site 869303000399 G2 box; other site 869303000400 G3 box; other site 869303000401 G3 box; other site 869303000402 Switch II region; other site 869303000403 Switch II region; other site 869303000404 G5 box; other site 869303000405 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 869303000406 RNA/DNA hybrid binding site [nucleotide binding]; other site 869303000407 active site 869303000408 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 869303000409 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 869303000410 Cl- selectivity filter; other site 869303000411 Cl- binding residues [ion binding]; other site 869303000412 pore gating glutamate residue; other site 869303000413 dimer interface [polypeptide binding]; other site 869303000414 H+/Cl- coupling transport residue; other site 869303000415 TrkA-C domain; Region: TrkA_C; pfam02080 869303000416 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 869303000417 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869303000418 active site 869303000419 DNA binding site [nucleotide binding] 869303000420 Int/Topo IB signature motif; other site 869303000421 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869303000422 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 869303000423 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 869303000424 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869303000425 E3 interaction surface; other site 869303000426 lipoyl attachment site [posttranslational modification]; other site 869303000427 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 869303000428 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 869303000429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869303000430 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869303000431 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 869303000432 e3 binding domain; Region: E3_binding; pfam02817 869303000433 e3 binding domain; Region: E3_binding; pfam02817 869303000434 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869303000435 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 869303000436 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 869303000437 alpha subunit interface [polypeptide binding]; other site 869303000438 TPP binding site [chemical binding]; other site 869303000439 heterodimer interface [polypeptide binding]; other site 869303000440 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869303000441 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 869303000442 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 869303000443 tetramer interface [polypeptide binding]; other site 869303000444 TPP-binding site [chemical binding]; other site 869303000445 heterodimer interface [polypeptide binding]; other site 869303000446 phosphorylation loop region [posttranslational modification] 869303000447 multidrug efflux protein; Reviewed; Region: PRK01766 869303000448 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 869303000449 cation binding site [ion binding]; other site 869303000450 dihydroorotase; Validated; Region: pyrC; PRK09357 869303000451 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869303000452 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 869303000453 active site 869303000454 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869303000455 putative active site [active] 869303000456 nucleotide binding site [chemical binding]; other site 869303000457 nudix motif; other site 869303000458 putative metal binding site [ion binding]; other site 869303000459 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 869303000460 ligand binding site [chemical binding]; other site 869303000461 active site 869303000462 UGI interface [polypeptide binding]; other site 869303000463 catalytic site [active] 869303000464 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 869303000465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303000466 motif II; other site 869303000467 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 869303000468 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869303000469 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869303000470 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869303000471 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869303000472 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 869303000473 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869303000474 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869303000475 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869303000476 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869303000477 dimerization domain swap beta strand [polypeptide binding]; other site 869303000478 regulatory protein interface [polypeptide binding]; other site 869303000479 active site 869303000480 regulatory phosphorylation site [posttranslational modification]; other site 869303000481 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 869303000482 catalytic residues [active] 869303000483 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 869303000484 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 869303000485 Class I ribonucleotide reductase; Region: RNR_I; cd01679 869303000486 active site 869303000487 dimer interface [polypeptide binding]; other site 869303000488 catalytic residues [active] 869303000489 effector binding site; other site 869303000490 R2 peptide binding site; other site 869303000491 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 869303000492 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 869303000493 dimer interface [polypeptide binding]; other site 869303000494 putative radical transfer pathway; other site 869303000495 diiron center [ion binding]; other site 869303000496 tyrosyl radical; other site 869303000497 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869303000498 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869303000499 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869303000500 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 869303000501 beta-galactosidase; Region: BGL; TIGR03356 869303000502 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 869303000503 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869303000504 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 869303000505 active site 869303000506 P-loop; other site 869303000507 phosphorylation site [posttranslational modification] 869303000508 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869303000509 methionine cluster; other site 869303000510 active site 869303000511 phosphorylation site [posttranslational modification] 869303000512 metal binding site [ion binding]; metal-binding site 869303000513 CAT RNA binding domain; Region: CAT_RBD; smart01061 869303000514 transcriptional antiterminator BglG; Provisional; Region: PRK09772 869303000515 PRD domain; Region: PRD; pfam00874 869303000516 PRD domain; Region: PRD; pfam00874 869303000517 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 869303000518 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869303000519 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 869303000520 putative substrate binding site [chemical binding]; other site 869303000521 putative ATP binding site [chemical binding]; other site 869303000522 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 869303000523 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 869303000524 N-terminal truncation due to IS insertion 869303000526 C-terminal truncation due to IS insertion 869303000527 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869303000528 active site 869303000529 phosphorylation site [posttranslational modification] 869303000530 GTP-binding protein LepA; Provisional; Region: PRK05433 869303000531 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 869303000532 G1 box; other site 869303000533 putative GEF interaction site [polypeptide binding]; other site 869303000534 GTP/Mg2+ binding site [chemical binding]; other site 869303000535 Switch I region; other site 869303000536 G2 box; other site 869303000537 G3 box; other site 869303000538 Switch II region; other site 869303000539 G4 box; other site 869303000540 G5 box; other site 869303000541 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 869303000542 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 869303000543 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 869303000544 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 869303000545 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869303000546 active site 869303000547 metal binding site [ion binding]; metal-binding site 869303000548 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 869303000549 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869303000550 Walker A/P-loop; other site 869303000551 ATP binding site [chemical binding]; other site 869303000552 Q-loop/lid; other site 869303000553 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869303000554 ABC transporter signature motif; other site 869303000555 Walker B; other site 869303000556 D-loop; other site 869303000557 H-loop/switch region; other site 869303000558 Arginine repressor [Transcription]; Region: ArgR; COG1438 869303000559 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869303000560 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869303000561 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 869303000562 S4 RNA-binding domain; Region: S4; smart00363 869303000563 RNA binding surface [nucleotide binding]; other site 869303000564 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 869303000565 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869303000566 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869303000567 substrate binding pocket [chemical binding]; other site 869303000568 chain length determination region; other site 869303000569 substrate-Mg2+ binding site; other site 869303000570 catalytic residues [active] 869303000571 aspartate-rich region 1; other site 869303000572 active site lid residues [active] 869303000573 aspartate-rich region 2; other site 869303000574 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 869303000575 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 869303000576 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 869303000577 generic binding surface II; other site 869303000578 generic binding surface I; other site 869303000579 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 869303000580 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 869303000581 Sugar specificity; other site 869303000582 Pyrimidine base specificity; other site 869303000583 ATP-binding site [chemical binding]; other site 869303000584 Enterocin A Immunity; Region: EntA_Immun; pfam08951 869303000585 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 869303000586 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 869303000587 RNA binding site [nucleotide binding]; other site 869303000588 active site 869303000589 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 869303000590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 869303000591 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 869303000593 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 869303000594 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 869303000595 active site 869303000596 catalytic site [active] 869303000597 DNA gyrase subunit A; Validated; Region: PRK05560 869303000598 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869303000599 CAP-like domain; other site 869303000600 active site 869303000601 primary dimer interface [polypeptide binding]; other site 869303000602 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869303000603 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869303000604 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869303000605 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869303000606 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869303000607 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869303000608 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 869303000609 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 869303000610 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869303000611 NAD binding site [chemical binding]; other site 869303000612 dimer interface [polypeptide binding]; other site 869303000613 substrate binding site [chemical binding]; other site 869303000614 Ion channel; Region: Ion_trans_2; pfam07885 869303000615 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 869303000616 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 869303000617 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869303000618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 869303000619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869303000620 putative active site [active] 869303000621 heme pocket [chemical binding]; other site 869303000622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869303000623 dimer interface [polypeptide binding]; other site 869303000624 phosphorylation site [posttranslational modification] 869303000625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303000626 ATP binding site [chemical binding]; other site 869303000627 Mg2+ binding site [ion binding]; other site 869303000628 G-X-G motif; other site 869303000629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869303000630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303000631 active site 869303000632 phosphorylation site [posttranslational modification] 869303000633 intermolecular recognition site; other site 869303000634 dimerization interface [polypeptide binding]; other site 869303000635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869303000636 DNA binding site [nucleotide binding] 869303000637 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 869303000638 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869303000639 minor groove reading motif; other site 869303000640 helix-hairpin-helix signature motif; other site 869303000641 substrate binding pocket [chemical binding]; other site 869303000642 active site 869303000643 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 869303000644 DNA binding and oxoG recognition site [nucleotide binding] 869303000645 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 869303000646 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 869303000647 Potassium binding sites [ion binding]; other site 869303000648 Cesium cation binding sites [ion binding]; other site 869303000649 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 869303000650 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 869303000651 Flavoprotein; Region: Flavoprotein; pfam02441 869303000652 Predicted membrane protein [Function unknown]; Region: COG4684 869303000653 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 869303000654 HTH domain; Region: HTH_11; pfam08279 869303000655 3H domain; Region: 3H; pfam02829 869303000656 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869303000657 putative active site [active] 869303000658 nucleotide binding site [chemical binding]; other site 869303000659 nudix motif; other site 869303000660 putative metal binding site [ion binding]; other site 869303000661 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869303000662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303000663 Coenzyme A binding pocket [chemical binding]; other site 869303000664 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869303000665 excinuclease ABC subunit B; Provisional; Region: PRK05298 869303000666 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869303000667 ATP binding site [chemical binding]; other site 869303000668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869303000669 nucleotide binding region [chemical binding]; other site 869303000670 ATP-binding site [chemical binding]; other site 869303000671 Ultra-violet resistance protein B; Region: UvrB; pfam12344 869303000672 UvrB/uvrC motif; Region: UVR; pfam02151 869303000673 CAAX protease self-immunity; Region: Abi; pfam02517 869303000674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303000675 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869303000676 substrate binding pocket [chemical binding]; other site 869303000677 membrane-bound complex binding site; other site 869303000678 hinge residues; other site 869303000679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303000680 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869303000681 substrate binding pocket [chemical binding]; other site 869303000682 membrane-bound complex binding site; other site 869303000683 hinge residues; other site 869303000684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303000685 dimer interface [polypeptide binding]; other site 869303000686 conserved gate region; other site 869303000687 putative PBP binding loops; other site 869303000688 ABC-ATPase subunit interface; other site 869303000689 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869303000690 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869303000691 Walker A/P-loop; other site 869303000692 ATP binding site [chemical binding]; other site 869303000693 Q-loop/lid; other site 869303000694 ABC transporter signature motif; other site 869303000695 Walker B; other site 869303000696 D-loop; other site 869303000697 H-loop/switch region; other site 869303000698 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 869303000699 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 869303000700 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 869303000701 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 869303000702 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 869303000703 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869303000704 P loop; other site 869303000705 GTP binding site [chemical binding]; other site 869303000706 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869303000707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303000708 motif II; other site 869303000709 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869303000710 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869303000711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303000712 active site 869303000713 motif I; other site 869303000714 motif II; other site 869303000715 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869303000716 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 869303000717 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869303000718 Walker A/P-loop; other site 869303000719 ATP binding site [chemical binding]; other site 869303000720 Q-loop/lid; other site 869303000721 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 869303000722 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869303000723 ABC transporter signature motif; other site 869303000724 Walker B; other site 869303000725 D-loop; other site 869303000726 H-loop/switch region; other site 869303000727 ribonuclease III; Reviewed; Region: rnc; PRK00102 869303000728 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 869303000729 dimerization interface [polypeptide binding]; other site 869303000730 active site 869303000731 metal binding site [ion binding]; metal-binding site 869303000732 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 869303000733 dsRNA binding site [nucleotide binding]; other site 869303000734 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 869303000735 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869303000736 active site 869303000737 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 869303000738 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 869303000739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303000740 Walker A motif; other site 869303000741 ATP binding site [chemical binding]; other site 869303000742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869303000744 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 869303000745 substrate binding site [chemical binding]; other site 869303000746 Predicted membrane protein [Function unknown]; Region: COG3326 869303000749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 869303000750 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 869303000751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 869303000752 DNA topoisomerase I; Validated; Region: PRK05582 869303000753 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 869303000754 active site 869303000755 interdomain interaction site; other site 869303000756 putative metal-binding site [ion binding]; other site 869303000757 nucleotide binding site [chemical binding]; other site 869303000758 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869303000759 domain I; other site 869303000760 DNA binding groove [nucleotide binding] 869303000761 phosphate binding site [ion binding]; other site 869303000762 domain II; other site 869303000763 domain III; other site 869303000764 nucleotide binding site [chemical binding]; other site 869303000765 catalytic site [active] 869303000766 domain IV; other site 869303000767 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869303000768 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869303000769 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 869303000770 Predicted membrane protein [Function unknown]; Region: COG1808 869303000771 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 869303000772 DNA protecting protein DprA; Region: dprA; TIGR00732 869303000773 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 869303000774 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 869303000775 active site 869303000776 metal-binding site 869303000777 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 869303000778 Phosphotransferase enzyme family; Region: APH; pfam01636 869303000779 active site 869303000780 substrate binding site [chemical binding]; other site 869303000781 ATP binding site [chemical binding]; other site 869303000782 dimer interface [polypeptide binding]; other site 869303000783 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 869303000784 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869303000785 putative NAD(P) binding site [chemical binding]; other site 869303000786 putative catalytic Zn binding site [ion binding]; other site 869303000787 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 869303000788 substrate binding site; other site 869303000789 dimer interface; other site 869303000790 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869303000791 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 869303000792 LicD family; Region: LicD; cl01378 869303000793 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869303000794 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 869303000795 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869303000796 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869303000797 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 869303000798 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869303000799 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869303000800 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 869303000801 IMP binding site; other site 869303000802 dimer interface [polypeptide binding]; other site 869303000803 interdomain contacts; other site 869303000804 partial ornithine binding site; other site 869303000805 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 869303000806 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 869303000807 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 869303000808 catalytic site [active] 869303000809 subunit interface [polypeptide binding]; other site 869303000810 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 869303000811 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869303000812 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869303000813 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 869303000814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303000815 active site 869303000816 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 869303000817 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869303000818 minor groove reading motif; other site 869303000819 helix-hairpin-helix signature motif; other site 869303000820 substrate binding pocket [chemical binding]; other site 869303000821 active site 869303000822 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 869303000823 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869303000824 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303000825 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303000826 heat shock protein HtpX; Provisional; Region: PRK04897 869303000827 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 869303000828 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 869303000829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303000830 S-adenosylmethionine binding site [chemical binding]; other site 869303000831 uracil transporter; Provisional; Region: PRK10720 869303000832 signal recognition particle protein; Provisional; Region: PRK10867 869303000833 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 869303000834 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869303000835 P loop; other site 869303000836 GTP binding site [chemical binding]; other site 869303000837 Signal peptide binding domain; Region: SRP_SPB; pfam02978 869303000838 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 869303000839 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869303000840 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 869303000841 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 869303000842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869303000843 Zn2+ binding site [ion binding]; other site 869303000844 Mg2+ binding site [ion binding]; other site 869303000845 sugar phosphate phosphatase; Provisional; Region: PRK10513 869303000846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303000847 active site 869303000848 motif I; other site 869303000849 motif II; other site 869303000850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303000851 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 869303000852 camphor resistance protein CrcB; Provisional; Region: PRK14229 869303000853 camphor resistance protein CrcB; Provisional; Region: PRK14221 869303000854 hypothetical protein; Provisional; Region: PRK07248 869303000855 flavodoxin; Validated; Region: PRK07308 869303000856 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 869303000857 DHH family; Region: DHH; pfam01368 869303000858 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 869303000861 glutamate dehydrogenase; Provisional; Region: PRK09414 869303000862 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 869303000863 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 869303000864 NAD(P) binding site [chemical binding]; other site 869303000869 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869303000870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869303000871 Walker A/P-loop; other site 869303000872 ATP binding site [chemical binding]; other site 869303000873 Q-loop/lid; other site 869303000874 ABC transporter signature motif; other site 869303000875 Walker B; other site 869303000876 D-loop; other site 869303000877 H-loop/switch region; other site 869303000881 CAAX protease self-immunity; Region: Abi; pfam02517 869303000882 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 869303000883 ArsC family; Region: ArsC; pfam03960 869303000884 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 869303000885 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 869303000886 core dimer interface [polypeptide binding]; other site 869303000887 L10 interface [polypeptide binding]; other site 869303000888 L11 interface [polypeptide binding]; other site 869303000889 putative EF-Tu interaction site [polypeptide binding]; other site 869303000890 putative EF-G interaction site [polypeptide binding]; other site 869303000891 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 869303000892 23S rRNA interface [nucleotide binding]; other site 869303000893 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 869303000894 chlorohydrolase; Validated; Region: PRK06687 869303000895 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 869303000896 active site 869303000897 putative substrate binding pocket [chemical binding]; other site 869303000898 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869303000899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869303000900 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869303000901 Walker A/P-loop; other site 869303000902 ATP binding site [chemical binding]; other site 869303000903 Q-loop/lid; other site 869303000904 ABC transporter signature motif; other site 869303000905 Walker B; other site 869303000906 D-loop; other site 869303000907 H-loop/switch region; other site 869303000908 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869303000909 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869303000910 APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148 869303000911 putative ligand binding site [chemical binding]; other site 869303000912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303000913 Walker A/P-loop; other site 869303000914 ATP binding site [chemical binding]; other site 869303000915 Q-loop/lid; other site 869303000916 ABC transporter signature motif; other site 869303000917 Walker B; other site 869303000918 D-loop; other site 869303000919 H-loop/switch region; other site 869303000920 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 869303000921 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 869303000922 SelR domain; Region: SelR; pfam01641 869303000923 homoserine kinase; Provisional; Region: PRK01212 869303000924 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869303000925 homoserine dehydrogenase; Provisional; Region: PRK06349 869303000926 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 869303000927 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 869303000928 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 869303000929 adaptor protein; Provisional; Region: PRK02315 869303000930 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 869303000931 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869303000932 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869303000933 active site 869303000934 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869303000935 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 869303000936 putative ADP-binding pocket [chemical binding]; other site 869303000937 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869303000938 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869303000939 prephenate dehydratase; Provisional; Region: PRK11898 869303000940 Prephenate dehydratase; Region: PDT; pfam00800 869303000941 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 869303000942 putative L-Phe binding site [chemical binding]; other site 869303000943 shikimate kinase; Reviewed; Region: aroK; PRK00131 869303000944 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 869303000945 ADP binding site [chemical binding]; other site 869303000946 magnesium binding site [ion binding]; other site 869303000947 putative shikimate binding site; other site 869303000948 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 869303000949 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 869303000950 hinge; other site 869303000951 active site 869303000952 hypothetical protein; Provisional; Region: PRK13676 869303000953 prephenate dehydrogenase; Validated; Region: PRK06545 869303000954 prephenate dehydrogenase; Validated; Region: PRK08507 869303000955 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 869303000956 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 869303000957 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 869303000958 Tetramer interface [polypeptide binding]; other site 869303000959 active site 869303000960 FMN-binding site [chemical binding]; other site 869303000961 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869303000962 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 869303000963 active site 869303000964 dimer interface [polypeptide binding]; other site 869303000965 metal binding site [ion binding]; metal-binding site 869303000966 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 869303000967 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 869303000968 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869303000969 shikimate binding site; other site 869303000970 NAD(P) binding site [chemical binding]; other site 869303000971 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 869303000972 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 869303000973 active site 869303000974 catalytic residue [active] 869303000975 dimer interface [polypeptide binding]; other site 869303000976 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 869303000977 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 869303000978 putative RNA binding site [nucleotide binding]; other site 869303000979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303000981 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869303000982 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869303000983 Walker A/P-loop; other site 869303000984 ATP binding site [chemical binding]; other site 869303000985 Q-loop/lid; other site 869303000986 ABC transporter signature motif; other site 869303000987 Walker B; other site 869303000988 D-loop; other site 869303000989 H-loop/switch region; other site 869303000990 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 869303000991 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 869303000992 active site 869303000993 Na/Ca binding site [ion binding]; other site 869303000994 catalytic site [active] 869303000995 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 869303000996 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 869303000997 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 869303000998 motif 1; other site 869303000999 active site 869303001000 motif 2; other site 869303001001 motif 3; other site 869303001002 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869303001003 DHHA1 domain; Region: DHHA1; pfam02272 869303001004 Uncharacterized conserved protein [Function unknown]; Region: COG4894 869303001005 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 869303001006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869303001007 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869303001008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001009 dimer interface [polypeptide binding]; other site 869303001010 conserved gate region; other site 869303001011 putative PBP binding loops; other site 869303001012 ABC-ATPase subunit interface; other site 869303001013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001014 dimer interface [polypeptide binding]; other site 869303001015 conserved gate region; other site 869303001016 putative PBP binding loops; other site 869303001017 ABC-ATPase subunit interface; other site 869303001018 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869303001019 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 869303001020 Walker A/P-loop; other site 869303001021 ATP binding site [chemical binding]; other site 869303001022 Q-loop/lid; other site 869303001023 ABC transporter signature motif; other site 869303001024 Walker B; other site 869303001025 D-loop; other site 869303001026 H-loop/switch region; other site 869303001027 TOBE domain; Region: TOBE_2; pfam08402 869303001028 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 869303001029 FAD binding domain; Region: FAD_binding_4; pfam01565 869303001030 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 869303001032 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 869303001033 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 869303001034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869303001035 DNA-binding site [nucleotide binding]; DNA binding site 869303001036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869303001037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303001038 homodimer interface [polypeptide binding]; other site 869303001039 catalytic residue [active] 869303001040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303001041 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869303001042 substrate binding pocket [chemical binding]; other site 869303001043 membrane-bound complex binding site; other site 869303001044 hinge residues; other site 869303001045 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869303001046 PhoU domain; Region: PhoU; pfam01895 869303001047 PhoU domain; Region: PhoU; pfam01895 869303001048 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 869303001049 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869303001050 Walker A/P-loop; other site 869303001051 ATP binding site [chemical binding]; other site 869303001052 Q-loop/lid; other site 869303001053 ABC transporter signature motif; other site 869303001054 Walker B; other site 869303001055 D-loop; other site 869303001056 H-loop/switch region; other site 869303001057 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 869303001058 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869303001059 Walker A/P-loop; other site 869303001060 ATP binding site [chemical binding]; other site 869303001061 Q-loop/lid; other site 869303001062 ABC transporter signature motif; other site 869303001063 Walker B; other site 869303001064 D-loop; other site 869303001065 H-loop/switch region; other site 869303001066 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 869303001067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001068 dimer interface [polypeptide binding]; other site 869303001069 conserved gate region; other site 869303001070 putative PBP binding loops; other site 869303001071 ABC-ATPase subunit interface; other site 869303001072 sulfate transport protein; Provisional; Region: cysT; CHL00187 869303001073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001074 dimer interface [polypeptide binding]; other site 869303001075 conserved gate region; other site 869303001076 putative PBP binding loops; other site 869303001077 ABC-ATPase subunit interface; other site 869303001078 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 869303001079 phosphate binding protein; Region: ptsS_2; TIGR02136 869303001080 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 869303001081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303001082 S-adenosylmethionine binding site [chemical binding]; other site 869303001083 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 869303001084 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 869303001085 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 869303001086 active site 869303001087 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 869303001088 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 869303001089 ArsC family; Region: ArsC; pfam03960 869303001090 putative catalytic residues [active] 869303001091 thiol/disulfide switch; other site 869303001092 Predicted membrane protein [Function unknown]; Region: COG4478 869303001093 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 869303001094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303001095 active site 869303001096 motif I; other site 869303001097 motif II; other site 869303001098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303001099 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 869303001100 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869303001101 active site 869303001102 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869303001103 active site 869303001104 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 869303001105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869303001106 FeS/SAM binding site; other site 869303001107 HemN C-terminal domain; Region: HemN_C; pfam06969 869303001108 YtxH-like protein; Region: YtxH; pfam12732 869303001109 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 869303001110 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 869303001111 HPr kinase/phosphorylase; Provisional; Region: PRK05428 869303001112 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 869303001113 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 869303001114 Hpr binding site; other site 869303001115 active site 869303001116 homohexamer subunit interaction site [polypeptide binding]; other site 869303001117 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 869303001118 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869303001119 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 869303001120 active site 869303001121 trimer interface [polypeptide binding]; other site 869303001122 allosteric site; other site 869303001123 active site lid [active] 869303001124 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869303001125 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 869303001126 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 869303001128 start codon has mutated to CTG, hence this CDS is marked as a pseudogene 869303001129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869303001130 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869303001131 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 869303001132 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 869303001133 homodimer interface [polypeptide binding]; other site 869303001134 NAD binding pocket [chemical binding]; other site 869303001135 ATP binding pocket [chemical binding]; other site 869303001136 Mg binding site [ion binding]; other site 869303001137 active-site loop [active] 869303001138 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 869303001139 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 869303001140 active site 869303001141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303001142 non-specific DNA binding site [nucleotide binding]; other site 869303001143 salt bridge; other site 869303001144 sequence-specific DNA binding site [nucleotide binding]; other site 869303001147 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 869303001148 CHY zinc finger; Region: zf-CHY; pfam05495 869303001149 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869303001150 Peptidase family U32; Region: Peptidase_U32; pfam01136 869303001153 Helix-turn-helix domain; Region: HTH_18; pfam12833 869303001154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869303001155 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869303001156 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869303001157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303001158 Walker A/P-loop; other site 869303001159 ATP binding site [chemical binding]; other site 869303001160 Q-loop/lid; other site 869303001161 ABC transporter signature motif; other site 869303001162 Walker B; other site 869303001163 D-loop; other site 869303001164 H-loop/switch region; other site 869303001165 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869303001166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303001167 Walker A/P-loop; other site 869303001168 ATP binding site [chemical binding]; other site 869303001169 Q-loop/lid; other site 869303001170 ABC transporter signature motif; other site 869303001171 Walker B; other site 869303001172 D-loop; other site 869303001173 H-loop/switch region; other site 869303001174 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 869303001175 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869303001176 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869303001177 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869303001178 Walker A/P-loop; other site 869303001179 ATP binding site [chemical binding]; other site 869303001180 Q-loop/lid; other site 869303001181 ABC transporter signature motif; other site 869303001182 Walker B; other site 869303001183 D-loop; other site 869303001184 H-loop/switch region; other site 869303001185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303001186 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 869303001187 Walker A/P-loop; other site 869303001188 ATP binding site [chemical binding]; other site 869303001189 Q-loop/lid; other site 869303001190 ABC transporter signature motif; other site 869303001191 Walker B; other site 869303001192 D-loop; other site 869303001193 H-loop/switch region; other site 869303001196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 869303001197 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 869303001199 GMP synthase; Reviewed; Region: guaA; PRK00074 869303001200 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 869303001201 AMP/PPi binding site [chemical binding]; other site 869303001202 candidate oxyanion hole; other site 869303001203 catalytic triad [active] 869303001204 potential glutamine specificity residues [chemical binding]; other site 869303001205 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 869303001206 ATP Binding subdomain [chemical binding]; other site 869303001207 Dimerization subdomain; other site 869303001208 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869303001209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869303001210 DNA-binding site [nucleotide binding]; DNA binding site 869303001211 UTRA domain; Region: UTRA; pfam07702 869303001213 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 869303001214 Beta-lactamase; Region: Beta-lactamase; pfam00144 869303001215 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 869303001216 active site 869303001217 catalytic triad [active] 869303001218 oxyanion hole [active] 869303001219 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869303001220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303001221 active site 869303001222 motif I; other site 869303001223 motif II; other site 869303001224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303001226 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869303001227 active site 869303001228 catalytic residues [active] 869303001229 metal binding site [ion binding]; metal-binding site 869303001230 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869303001231 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 869303001232 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869303001233 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 869303001234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869303001235 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869303001236 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 869303001237 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869303001238 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869303001239 Walker A/P-loop; other site 869303001240 ATP binding site [chemical binding]; other site 869303001241 Q-loop/lid; other site 869303001242 ABC transporter signature motif; other site 869303001243 Walker B; other site 869303001244 D-loop; other site 869303001245 H-loop/switch region; other site 869303001246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869303001247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001248 ABC-ATPase subunit interface; other site 869303001249 putative PBP binding loops; other site 869303001250 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 869303001251 putative ArsC-like catalytic residues; other site 869303001252 putative TRX-like catalytic residues [active] 869303001253 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 869303001254 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 869303001255 DNA binding site [nucleotide binding] 869303001256 active site 869303001257 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869303001258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869303001259 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 869303001260 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 869303001261 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 869303001262 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 869303001263 predicted active site [active] 869303001264 catalytic triad [active] 869303001265 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 869303001266 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 869303001267 active site 869303001268 multimer interface [polypeptide binding]; other site 869303001269 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 869303001270 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869303001271 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869303001272 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 869303001273 ApbE family; Region: ApbE; pfam02424 869303001274 Predicted flavoprotein [General function prediction only]; Region: COG0431 869303001275 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869303001276 Predicted flavoprotein [General function prediction only]; Region: COG0431 869303001277 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869303001278 PAS domain; Region: PAS_10; pfam13596 869303001279 hypothetical protein; Provisional; Region: PRK02539 869303001280 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 869303001281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 869303001282 DALR anticodon binding domain; Region: DALR_1; pfam05746 869303001283 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 869303001284 dimer interface [polypeptide binding]; other site 869303001285 motif 1; other site 869303001286 active site 869303001287 motif 2; other site 869303001288 motif 3; other site 869303001289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869303001290 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869303001291 active site 869303001292 catalytic tetrad [active] 869303001293 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 869303001294 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 869303001295 NodB motif; other site 869303001296 active site 869303001297 catalytic site [active] 869303001298 Zn binding site [ion binding]; other site 869303001299 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 869303001300 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869303001301 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869303001302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869303001303 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869303001304 ATP binding site [chemical binding]; other site 869303001305 putative Mg++ binding site [ion binding]; other site 869303001306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869303001307 nucleotide binding region [chemical binding]; other site 869303001308 ATP-binding site [chemical binding]; other site 869303001310 elongation factor Tu; Reviewed; Region: PRK00049 869303001311 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 869303001312 G1 box; other site 869303001313 GEF interaction site [polypeptide binding]; other site 869303001314 GTP/Mg2+ binding site [chemical binding]; other site 869303001315 Switch I region; other site 869303001316 G2 box; other site 869303001317 G3 box; other site 869303001318 Switch II region; other site 869303001319 G4 box; other site 869303001320 G5 box; other site 869303001321 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 869303001322 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 869303001323 Antibiotic Binding Site [chemical binding]; other site 869303001324 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869303001325 amphipathic channel; other site 869303001326 Asn-Pro-Ala signature motifs; other site 869303001329 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 869303001330 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 869303001331 active site 869303001332 substrate binding site [chemical binding]; other site 869303001333 metal binding site [ion binding]; metal-binding site 869303001334 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869303001335 catalytic residues [active] 869303001336 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869303001337 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303001338 substrate binding pocket [chemical binding]; other site 869303001339 membrane-bound complex binding site; other site 869303001340 hinge residues; other site 869303001341 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869303001342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303001343 Walker A/P-loop; other site 869303001344 ATP binding site [chemical binding]; other site 869303001345 Q-loop/lid; other site 869303001346 ABC transporter signature motif; other site 869303001347 Walker B; other site 869303001348 D-loop; other site 869303001349 H-loop/switch region; other site 869303001350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001351 dimer interface [polypeptide binding]; other site 869303001352 conserved gate region; other site 869303001353 putative PBP binding loops; other site 869303001354 ABC-ATPase subunit interface; other site 869303001355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869303001356 TPR motif; other site 869303001357 binding surface 869303001358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869303001359 binding surface 869303001360 TPR motif; other site 869303001361 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869303001362 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869303001363 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 869303001364 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 869303001365 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 869303001366 gamma subunit interface [polypeptide binding]; other site 869303001367 epsilon subunit interface [polypeptide binding]; other site 869303001368 LBP interface [polypeptide binding]; other site 869303001369 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 869303001370 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869303001371 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 869303001372 alpha subunit interaction interface [polypeptide binding]; other site 869303001373 Walker A motif; other site 869303001374 ATP binding site [chemical binding]; other site 869303001375 Walker B motif; other site 869303001376 inhibitor binding site; inhibition site 869303001377 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869303001378 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 869303001379 core domain interface [polypeptide binding]; other site 869303001380 delta subunit interface [polypeptide binding]; other site 869303001381 epsilon subunit interface [polypeptide binding]; other site 869303001382 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 869303001383 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869303001384 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 869303001385 beta subunit interaction interface [polypeptide binding]; other site 869303001386 Walker A motif; other site 869303001387 ATP binding site [chemical binding]; other site 869303001388 Walker B motif; other site 869303001389 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869303001390 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 869303001391 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 869303001392 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 869303001393 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 869303001394 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 869303001395 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 869303001396 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 869303001398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303001399 Coenzyme A binding pocket [chemical binding]; other site 869303001400 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 869303001401 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 869303001402 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869303001403 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 869303001404 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 869303001405 dimerization interface [polypeptide binding]; other site 869303001406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 869303001407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303001408 Coenzyme A binding pocket [chemical binding]; other site 869303001409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303001410 Coenzyme A binding pocket [chemical binding]; other site 869303001411 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 869303001412 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869303001413 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869303001414 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869303001415 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 869303001416 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 869303001417 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869303001418 ATP binding site [chemical binding]; other site 869303001419 putative Mg++ binding site [ion binding]; other site 869303001420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869303001421 nucleotide binding region [chemical binding]; other site 869303001422 ATP-binding site [chemical binding]; other site 869303001423 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 869303001424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869303001425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303001426 homodimer interface [polypeptide binding]; other site 869303001427 catalytic residue [active] 869303001428 cystathionine gamma-synthase; Reviewed; Region: PRK07269 869303001429 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869303001430 homodimer interface [polypeptide binding]; other site 869303001431 substrate-cofactor binding pocket; other site 869303001432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303001433 catalytic residue [active] 869303001435 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869303001436 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869303001437 peptide binding site [polypeptide binding]; other site 869303001438 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869303001439 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 869303001440 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 869303001441 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869303001442 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869303001443 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869303001444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 869303001445 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 869303001446 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 869303001447 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 869303001448 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 869303001449 DHH family; Region: DHH; pfam01368 869303001450 DHHA2 domain; Region: DHHA2; pfam02833 869303001451 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 869303001452 GIY-YIG motif/motif A; other site 869303001453 putative active site [active] 869303001454 putative metal binding site [ion binding]; other site 869303001455 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 869303001456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303001457 S-adenosylmethionine binding site [chemical binding]; other site 869303001458 hypothetical protein; Provisional; Region: PRK07252 869303001459 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 869303001460 RNA binding site [nucleotide binding]; other site 869303001461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303001462 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869303001463 active site 869303001464 motif I; other site 869303001465 motif II; other site 869303001466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303001467 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 869303001468 active site 869303001469 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 869303001470 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869303001471 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869303001472 dimer interface [polypeptide binding]; other site 869303001473 ssDNA binding site [nucleotide binding]; other site 869303001474 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869303001475 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 869303001476 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 869303001477 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 869303001478 putative dimer interface [polypeptide binding]; other site 869303001479 putative anticodon binding site; other site 869303001480 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 869303001481 homodimer interface [polypeptide binding]; other site 869303001482 motif 1; other site 869303001483 motif 2; other site 869303001484 active site 869303001485 motif 3; other site 869303001486 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 869303001487 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869303001488 aspartate aminotransferase; Provisional; Region: PRK05764 869303001489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869303001490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303001491 homodimer interface [polypeptide binding]; other site 869303001492 catalytic residue [active] 869303001493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 869303001494 Predicted flavoprotein [General function prediction only]; Region: COG0431 869303001495 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869303001496 hypothetical protein; Validated; Region: PRK02101 869303001497 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869303001498 active site 869303001499 catalytic residues [active] 869303001500 metal binding site [ion binding]; metal-binding site 869303001501 putative S-transferase; Provisional; Region: PRK11752 869303001502 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 869303001503 C-terminal domain interface [polypeptide binding]; other site 869303001504 GSH binding site (G-site) [chemical binding]; other site 869303001505 dimer interface [polypeptide binding]; other site 869303001506 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 869303001507 N-terminal domain interface [polypeptide binding]; other site 869303001508 dimer interface [polypeptide binding]; other site 869303001509 substrate binding pocket (H-site) [chemical binding]; other site 869303001510 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 869303001511 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 869303001512 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869303001513 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 869303001514 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 869303001515 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 869303001516 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 869303001517 Cation efflux family; Region: Cation_efflux; pfam01545 869303001518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 869303001519 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869303001520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303001521 Walker A/P-loop; other site 869303001522 ATP binding site [chemical binding]; other site 869303001523 Q-loop/lid; other site 869303001524 ABC transporter signature motif; other site 869303001525 Walker B; other site 869303001526 D-loop; other site 869303001527 H-loop/switch region; other site 869303001528 ABC transporter; Region: ABC_tran_2; pfam12848 869303001529 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303001530 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 869303001531 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869303001532 active site 869303001533 NTP binding site [chemical binding]; other site 869303001534 metal binding triad [ion binding]; metal-binding site 869303001535 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869303001536 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 869303001537 dihydrodipicolinate reductase; Provisional; Region: PRK00048 869303001538 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 869303001539 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 869303001540 EDD domain protein, DegV family; Region: DegV; TIGR00762 869303001541 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869303001542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 869303001543 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 869303001544 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 869303001545 active site 869303001546 substrate binding site [chemical binding]; other site 869303001547 metal binding site [ion binding]; metal-binding site 869303001548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 869303001549 YbbR-like protein; Region: YbbR; pfam07949 869303001550 Uncharacterized conserved protein [Function unknown]; Region: COG1624 869303001551 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 869303001552 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 869303001553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869303001554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869303001555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 869303001556 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 869303001557 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 869303001558 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 869303001559 dimer interface [polypeptide binding]; other site 869303001560 phosphate binding site [ion binding]; other site 869303001561 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 869303001562 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869303001563 homotrimer interaction site [polypeptide binding]; other site 869303001564 putative active site [active] 869303001565 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 869303001566 G1 box; other site 869303001567 GTP/Mg2+ binding site [chemical binding]; other site 869303001568 Switch I region; other site 869303001569 G2 box; other site 869303001570 G3 box; other site 869303001571 Switch II region; other site 869303001572 G4 box; other site 869303001573 G5 box; other site 869303001574 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 869303001575 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 869303001576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303001577 Walker A motif; other site 869303001578 ATP binding site [chemical binding]; other site 869303001579 Walker B motif; other site 869303001580 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869303001581 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 869303001582 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 869303001583 folate binding site [chemical binding]; other site 869303001584 NADP+ binding site [chemical binding]; other site 869303001585 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 869303001586 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 869303001587 dimerization interface [polypeptide binding]; other site 869303001588 DPS ferroxidase diiron center [ion binding]; other site 869303001589 ion pore; other site 869303001591 triosephosphate isomerase; Provisional; Region: PRK14567 869303001592 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 869303001593 substrate binding site [chemical binding]; other site 869303001594 dimer interface [polypeptide binding]; other site 869303001595 catalytic triad [active] 869303001596 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 869303001597 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 869303001598 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 869303001599 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 869303001600 proposed active site lysine [active] 869303001601 conserved cys residue [active] 869303001602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303001603 active site 869303001604 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869303001605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303001606 S-adenosylmethionine binding site [chemical binding]; other site 869303001607 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 869303001608 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 869303001609 Walker A/P-loop; other site 869303001610 ATP binding site [chemical binding]; other site 869303001611 Q-loop/lid; other site 869303001612 ABC transporter signature motif; other site 869303001613 Walker B; other site 869303001614 D-loop; other site 869303001615 H-loop/switch region; other site 869303001616 TOBE domain; Region: TOBE_2; pfam08402 869303001617 Isochorismatase family; Region: Isochorismatase; pfam00857 869303001618 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 869303001619 catalytic triad [active] 869303001620 conserved cis-peptide bond; other site 869303001621 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 869303001622 CodY GAF-like domain; Region: CodY; pfam06018 869303001623 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869303001624 putative DNA binding site [nucleotide binding]; other site 869303001625 putative Zn2+ binding site [ion binding]; other site 869303001626 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 869303001627 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869303001628 ATP binding site [chemical binding]; other site 869303001629 Mg++ binding site [ion binding]; other site 869303001630 motif III; other site 869303001631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869303001632 nucleotide binding region [chemical binding]; other site 869303001633 ATP-binding site [chemical binding]; other site 869303001634 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 869303001635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869303001636 putative substrate translocation pore; other site 869303001637 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 869303001638 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 869303001639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869303001640 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869303001641 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 869303001642 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869303001643 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 869303001644 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 869303001645 catalytic triad [active] 869303001646 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869303001647 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869303001648 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869303001649 active site 869303001650 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869303001651 putative transposase OrfB; Reviewed; Region: PHA02517 869303001652 HTH-like domain; Region: HTH_21; pfam13276 869303001653 Integrase core domain; Region: rve; pfam00665 869303001654 Integrase core domain; Region: rve_2; pfam13333 869303001656 Predicted membrane protein [Function unknown]; Region: COG4720 869303001657 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869303001658 dimer interface [polypeptide binding]; other site 869303001659 substrate binding site [chemical binding]; other site 869303001660 ATP binding site [chemical binding]; other site 869303001661 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 869303001662 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 869303001663 dimerization interface 3.5A [polypeptide binding]; other site 869303001664 active site 869303001665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869303001666 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 869303001667 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 869303001668 PhnA protein; Region: PhnA; pfam03831 869303001669 cytidylate kinase; Provisional; Region: cmk; PRK00023 869303001670 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 869303001671 CMP-binding site; other site 869303001672 The sites determining sugar specificity; other site 869303001673 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 869303001674 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 869303001675 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 869303001676 Ligand binding site; other site 869303001677 Putative Catalytic site; other site 869303001678 DXD motif; other site 869303001679 UDP-glucose 4-epimerase; Region: PLN02240 869303001680 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 869303001681 NAD binding site [chemical binding]; other site 869303001682 homodimer interface [polypeptide binding]; other site 869303001683 active site 869303001684 substrate binding site [chemical binding]; other site 869303001685 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 869303001686 Uncharacterized conserved protein [Function unknown]; Region: COG0327 869303001687 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 869303001688 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 869303001689 Family of unknown function (DUF633); Region: DUF633; pfam04816 869303001691 putative transposase OrfB; Reviewed; Region: PHA02517 869303001692 HTH-like domain; Region: HTH_21; pfam13276 869303001693 Integrase core domain; Region: rve; pfam00665 869303001694 Integrase core domain; Region: rve_2; pfam13333 869303001696 transketolase; Provisional; Region: PTZ00089 869303001697 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869303001698 TPP-binding site [chemical binding]; other site 869303001699 dimer interface [polypeptide binding]; other site 869303001700 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 869303001701 PYR/PP interface [polypeptide binding]; other site 869303001702 dimer interface [polypeptide binding]; other site 869303001703 TPP binding site [chemical binding]; other site 869303001704 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869303001705 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 869303001706 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869303001707 substrate binding site [chemical binding]; other site 869303001708 hexamer interface [polypeptide binding]; other site 869303001709 metal binding site [ion binding]; metal-binding site 869303001710 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869303001711 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869303001712 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869303001713 active site 869303001714 P-loop; other site 869303001715 phosphorylation site [posttranslational modification] 869303001716 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869303001717 active site 869303001718 phosphorylation site [posttranslational modification] 869303001719 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869303001720 active site 869303001721 phosphorylation site [posttranslational modification] 869303001722 HTH domain; Region: HTH_11; pfam08279 869303001723 Mga helix-turn-helix domain; Region: Mga; pfam05043 869303001724 PRD domain; Region: PRD; pfam00874 869303001725 PRD domain; Region: PRD; pfam00874 869303001726 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869303001727 active site 869303001728 P-loop; other site 869303001729 phosphorylation site [posttranslational modification] 869303001730 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 869303001731 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869303001732 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 869303001733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303001734 motif II; other site 869303001735 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 869303001736 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869303001737 putative acyl-acceptor binding pocket; other site 869303001738 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 869303001739 Cadmium resistance transporter; Region: Cad; pfam03596 869303001740 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 869303001741 16S/18S rRNA binding site [nucleotide binding]; other site 869303001742 S13e-L30e interaction site [polypeptide binding]; other site 869303001743 25S rRNA binding site [nucleotide binding]; other site 869303001744 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 869303001745 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869303001746 NAD binding site [chemical binding]; other site 869303001747 substrate binding site [chemical binding]; other site 869303001748 putative active site [active] 869303001751 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 869303001752 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 869303001753 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869303001754 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 869303001755 active site 869303001756 dimer interface [polypeptide binding]; other site 869303001757 motif 1; other site 869303001758 motif 2; other site 869303001759 motif 3; other site 869303001760 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 869303001761 anticodon binding site; other site 869303001762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869303001763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303001764 ATP binding site [chemical binding]; other site 869303001765 Mg2+ binding site [ion binding]; other site 869303001766 G-X-G motif; other site 869303001767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869303001768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303001769 active site 869303001770 phosphorylation site [posttranslational modification] 869303001771 intermolecular recognition site; other site 869303001772 dimerization interface [polypeptide binding]; other site 869303001773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869303001774 DNA binding site [nucleotide binding] 869303001775 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 869303001776 nucleophilic elbow; other site 869303001777 catalytic triad; other site 869303001778 Predicted transcriptional regulator [Transcription]; Region: COG1959 869303001779 Transcriptional regulator; Region: Rrf2; pfam02082 869303001780 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 869303001781 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869303001782 active site 869303001783 metal binding site [ion binding]; metal-binding site 869303001784 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 869303001785 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 869303001786 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 869303001787 FeoA domain; Region: FeoA; pfam04023 869303001789 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 869303001790 putative active site [active] 869303001791 dimerization interface [polypeptide binding]; other site 869303001792 putative tRNAtyr binding site [nucleotide binding]; other site 869303001793 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 869303001794 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869303001795 Zn2+ binding site [ion binding]; other site 869303001796 Mg2+ binding site [ion binding]; other site 869303001797 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869303001798 synthetase active site [active] 869303001799 NTP binding site [chemical binding]; other site 869303001800 metal binding site [ion binding]; metal-binding site 869303001801 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 869303001802 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 869303001803 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 869303001804 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 869303001805 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 869303001806 active site 869303001807 Zn binding site [ion binding]; other site 869303001808 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 869303001809 Helix-turn-helix domain; Region: HTH_38; pfam13936 869303001810 Integrase core domain; Region: rve; pfam00665 869303001811 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869303001812 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869303001813 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869303001814 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869303001815 ABC-ATPase subunit interface; other site 869303001816 dimer interface [polypeptide binding]; other site 869303001817 putative PBP binding regions; other site 869303001818 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869303001819 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 869303001820 metal binding site [ion binding]; metal-binding site 869303001821 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 869303001822 dimer interface [polypeptide binding]; other site 869303001823 catalytic triad [active] 869303001824 peroxidatic and resolving cysteines [active] 869303001825 FtsX-like permease family; Region: FtsX; pfam02687 869303001826 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869303001827 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869303001828 FtsX-like permease family; Region: FtsX; pfam02687 869303001829 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869303001830 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869303001831 Walker A/P-loop; other site 869303001832 ATP binding site [chemical binding]; other site 869303001833 Q-loop/lid; other site 869303001834 ABC transporter signature motif; other site 869303001835 Walker B; other site 869303001836 D-loop; other site 869303001837 H-loop/switch region; other site 869303001838 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869303001839 catalytic core [active] 869303001840 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869303001841 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 869303001842 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869303001843 active site 869303001844 HIGH motif; other site 869303001845 nucleotide binding site [chemical binding]; other site 869303001846 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869303001847 active site 869303001848 KMSKS motif; other site 869303001849 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 869303001850 tRNA binding surface [nucleotide binding]; other site 869303001851 anticodon binding site; other site 869303001852 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869303001854 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 869303001855 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869303001856 RNA binding surface [nucleotide binding]; other site 869303001857 YGGT family; Region: YGGT; pfam02325 869303001858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 869303001859 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 869303001860 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869303001861 catalytic residue [active] 869303001862 cell division protein FtsZ; Validated; Region: PRK09330 869303001863 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 869303001864 nucleotide binding site [chemical binding]; other site 869303001865 SulA interaction site; other site 869303001866 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 869303001867 Cell division protein FtsA; Region: FtsA; smart00842 869303001868 Cell division protein FtsA; Region: FtsA; pfam14450 869303001869 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 869303001870 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 869303001871 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 869303001872 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 869303001873 nudix motif; other site 869303001874 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 869303001875 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869303001876 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869303001877 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869303001878 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 869303001879 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869303001880 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 869303001881 recombination protein RecR; Reviewed; Region: recR; PRK00076 869303001882 RecR protein; Region: RecR; pfam02132 869303001883 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 869303001884 putative active site [active] 869303001885 putative metal-binding site [ion binding]; other site 869303001886 tetramer interface [polypeptide binding]; other site 869303001887 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869303001888 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869303001889 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869303001890 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869303001891 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869303001892 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869303001893 putative active site [active] 869303001894 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869303001895 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869303001896 nucleotide binding site [chemical binding]; other site 869303001897 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869303001898 Class I aldolases; Region: Aldolase_Class_I; cl17187 869303001899 catalytic residue [active] 869303001900 Protein of unknown function, DUF624; Region: DUF624; pfam04854 869303001901 Domain of unknown function (DUF386); Region: DUF386; pfam04074 869303001902 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869303001903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001904 dimer interface [polypeptide binding]; other site 869303001905 conserved gate region; other site 869303001906 putative PBP binding loops; other site 869303001907 ABC-ATPase subunit interface; other site 869303001908 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869303001909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869303001910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001911 putative PBP binding loops; other site 869303001912 dimer interface [polypeptide binding]; other site 869303001913 ABC-ATPase subunit interface; other site 869303001914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869303001915 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869303001916 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 869303001917 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869303001918 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869303001919 active site turn [active] 869303001920 phosphorylation site [posttranslational modification] 869303001921 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 869303001922 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 869303001923 putative active site cavity [active] 869303001924 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869303001925 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869303001926 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869303001927 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 869303001928 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 869303001929 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869303001930 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869303001931 Asp-box motif; other site 869303001932 catalytic site [active] 869303001933 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869303001934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001935 dimer interface [polypeptide binding]; other site 869303001936 conserved gate region; other site 869303001937 putative PBP binding loops; other site 869303001938 ABC-ATPase subunit interface; other site 869303001939 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869303001940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303001941 dimer interface [polypeptide binding]; other site 869303001942 conserved gate region; other site 869303001943 putative PBP binding loops; other site 869303001944 ABC-ATPase subunit interface; other site 869303001945 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869303001946 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869303001947 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 869303001948 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869303001949 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 869303001950 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869303001951 catalytic site [active] 869303001952 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869303001953 Asp-box motif; other site 869303001954 Asp-box motif; other site 869303001955 catalytic site [active] 869303001956 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 869303001957 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 869303001958 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 869303001959 ssDNA binding site; other site 869303001960 generic binding surface II; other site 869303001961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869303001962 ATP binding site [chemical binding]; other site 869303001963 putative Mg++ binding site [ion binding]; other site 869303001964 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869303001965 nucleotide binding region [chemical binding]; other site 869303001966 ATP-binding site [chemical binding]; other site 869303001967 alanine racemase; Reviewed; Region: alr; PRK00053 869303001968 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 869303001969 active site 869303001970 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869303001971 dimer interface [polypeptide binding]; other site 869303001972 substrate binding site [chemical binding]; other site 869303001973 catalytic residues [active] 869303001974 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 869303001975 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 869303001976 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869303001977 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 869303001978 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869303001979 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 869303001980 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 869303001981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869303001982 nucleotide binding region [chemical binding]; other site 869303001983 ATP-binding site [chemical binding]; other site 869303001984 SEC-C motif; Region: SEC-C; pfam02810 869303001985 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 869303001986 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869303001987 Walker A/P-loop; other site 869303001988 ATP binding site [chemical binding]; other site 869303001989 Q-loop/lid; other site 869303001990 ABC transporter signature motif; other site 869303001991 Walker B; other site 869303001992 D-loop; other site 869303001993 H-loop/switch region; other site 869303001994 GTP-binding protein Der; Reviewed; Region: PRK00093 869303001995 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 869303001996 G1 box; other site 869303001997 GTP/Mg2+ binding site [chemical binding]; other site 869303001998 Switch I region; other site 869303001999 G2 box; other site 869303002000 Switch II region; other site 869303002001 G3 box; other site 869303002002 G4 box; other site 869303002003 G5 box; other site 869303002004 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 869303002005 G1 box; other site 869303002006 GTP/Mg2+ binding site [chemical binding]; other site 869303002007 Switch I region; other site 869303002008 G2 box; other site 869303002009 G3 box; other site 869303002010 Switch II region; other site 869303002011 G4 box; other site 869303002012 G5 box; other site 869303002013 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 869303002014 dimer interface [polypeptide binding]; other site 869303002015 FMN binding site [chemical binding]; other site 869303002016 NADPH bind site [chemical binding]; other site 869303002017 primosomal protein DnaI; Reviewed; Region: PRK08939 869303002018 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 869303002019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303002020 Walker A motif; other site 869303002021 ATP binding site [chemical binding]; other site 869303002022 Walker B motif; other site 869303002023 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 869303002024 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 869303002025 ATP cone domain; Region: ATP-cone; pfam03477 869303002026 Predicted transcriptional regulators [Transcription]; Region: COG1725 869303002027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869303002028 DNA-binding site [nucleotide binding]; DNA binding site 869303002029 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869303002030 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869303002031 Walker A/P-loop; other site 869303002032 ATP binding site [chemical binding]; other site 869303002033 Q-loop/lid; other site 869303002034 ABC transporter signature motif; other site 869303002035 Walker B; other site 869303002036 D-loop; other site 869303002037 H-loop/switch region; other site 869303002038 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 869303002039 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 869303002040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303002041 Walker A/P-loop; other site 869303002042 ATP binding site [chemical binding]; other site 869303002043 Q-loop/lid; other site 869303002044 ABC transporter signature motif; other site 869303002045 Walker B; other site 869303002046 D-loop; other site 869303002047 H-loop/switch region; other site 869303002048 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 869303002049 Uncharacterized conserved protein [Function unknown]; Region: COG0398 869303002050 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869303002051 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869303002052 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869303002053 nucleotide binding site [chemical binding]; other site 869303002054 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 869303002055 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869303002056 active site turn [active] 869303002057 phosphorylation site [posttranslational modification] 869303002058 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869303002059 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869303002060 HPr interaction site; other site 869303002061 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869303002062 active site 869303002063 phosphorylation site [posttranslational modification] 869303002064 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 869303002065 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 869303002066 substrate binding [chemical binding]; other site 869303002067 active site 869303002068 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 869303002069 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869303002070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869303002071 DNA binding site [nucleotide binding] 869303002072 domain linker motif; other site 869303002073 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 869303002074 dimerization interface [polypeptide binding]; other site 869303002075 ligand binding site [chemical binding]; other site 869303002076 sodium binding site [ion binding]; other site 869303002077 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 869303002078 homodimer interface [polypeptide binding]; other site 869303002079 catalytic residues [active] 869303002080 NAD binding site [chemical binding]; other site 869303002081 substrate binding pocket [chemical binding]; other site 869303002082 flexible flap; other site 869303002083 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 869303002084 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 869303002085 dimer interface [polypeptide binding]; other site 869303002086 active site 869303002087 IS1381 orfs A and B appear to have fused into the same reading frame due to a small deletion 869303002088 Uncharacterized conserved protein [Function unknown]; Region: COG3610 869303002089 Uncharacterized conserved protein [Function unknown]; Region: COG2966 869303002090 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 869303002091 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 869303002092 Catalytic domain of Protein Kinases; Region: PKc; cd00180 869303002093 active site 869303002094 ATP binding site [chemical binding]; other site 869303002095 substrate binding site [chemical binding]; other site 869303002096 activation loop (A-loop); other site 869303002097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 869303002098 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869303002099 PASTA domain; Region: PASTA; smart00740 869303002100 PASTA domain; Region: PASTA; smart00740 869303002101 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869303002102 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 869303002103 active site 869303002104 16S rRNA methyltransferase B; Provisional; Region: PRK14902 869303002105 NusB family; Region: NusB; pfam01029 869303002106 putative RNA binding site [nucleotide binding]; other site 869303002107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303002108 S-adenosylmethionine binding site [chemical binding]; other site 869303002109 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 869303002110 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 869303002111 putative active site [active] 869303002112 substrate binding site [chemical binding]; other site 869303002113 putative cosubstrate binding site; other site 869303002114 catalytic site [active] 869303002115 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 869303002116 substrate binding site [chemical binding]; other site 869303002117 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 869303002118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869303002119 ATP binding site [chemical binding]; other site 869303002120 putative Mg++ binding site [ion binding]; other site 869303002121 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869303002122 ATP-binding site [chemical binding]; other site 869303002123 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 869303002124 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 869303002125 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 869303002126 catalytic site [active] 869303002127 G-X2-G-X-G-K; other site 869303002128 hypothetical protein; Provisional; Region: PRK00106 869303002129 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869303002130 Zn2+ binding site [ion binding]; other site 869303002131 Mg2+ binding site [ion binding]; other site 869303002132 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 869303002133 hypothetical protein; Provisional; Region: PRK13670 869303002134 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 869303002135 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 869303002136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303002137 S-adenosylmethionine binding site [chemical binding]; other site 869303002138 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 869303002139 Isochorismatase family; Region: Isochorismatase; pfam00857 869303002140 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 869303002141 catalytic triad [active] 869303002142 conserved cis-peptide bond; other site 869303002143 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869303002144 Zn2+ binding site [ion binding]; other site 869303002145 Mg2+ binding site [ion binding]; other site 869303002146 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 869303002147 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 869303002148 active site 869303002149 (T/H)XGH motif; other site 869303002150 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 869303002151 GTPase YqeH; Provisional; Region: PRK13796 869303002152 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 869303002153 GTP/Mg2+ binding site [chemical binding]; other site 869303002154 G4 box; other site 869303002155 G5 box; other site 869303002156 G1 box; other site 869303002157 Switch I region; other site 869303002158 G2 box; other site 869303002159 G3 box; other site 869303002160 Switch II region; other site 869303002161 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 869303002162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303002163 active site 869303002164 motif I; other site 869303002165 motif II; other site 869303002166 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869303002167 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 869303002168 Cl binding site [ion binding]; other site 869303002169 oligomer interface [polypeptide binding]; other site 869303002170 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 869303002171 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869303002174 Predicted membrane protein [Function unknown]; Region: COG4129 869303002175 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 869303002176 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 869303002177 MarR family; Region: MarR; pfam01047 869303002178 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869303002179 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869303002180 catalytic residues [active] 869303002181 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 869303002182 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869303002183 amphipathic channel; other site 869303002184 Asn-Pro-Ala signature motifs; other site 869303002185 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 869303002186 oligoendopeptidase F; Region: pepF; TIGR00181 869303002187 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 869303002188 Zn binding site [ion binding]; other site 869303002189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 869303002190 RNA methyltransferase, RsmE family; Region: TIGR00046 869303002191 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 869303002192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303002193 S-adenosylmethionine binding site [chemical binding]; other site 869303002194 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 869303002195 nudix motif; other site 869303002196 Peptidase family M50; Region: Peptidase_M50; pfam02163 869303002197 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 869303002198 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 869303002199 recombination factor protein RarA; Reviewed; Region: PRK13342 869303002200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303002201 Walker A motif; other site 869303002202 ATP binding site [chemical binding]; other site 869303002203 Walker B motif; other site 869303002204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869303002205 arginine finger; other site 869303002206 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 869303002207 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 869303002208 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 869303002209 substrate binding [chemical binding]; other site 869303002210 active site 869303002211 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 869303002212 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869303002213 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869303002214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002215 dimer interface [polypeptide binding]; other site 869303002216 conserved gate region; other site 869303002217 ABC-ATPase subunit interface; other site 869303002218 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869303002219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002220 dimer interface [polypeptide binding]; other site 869303002221 conserved gate region; other site 869303002222 ABC-ATPase subunit interface; other site 869303002223 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869303002224 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869303002225 DNA binding site [nucleotide binding] 869303002226 domain linker motif; other site 869303002227 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 869303002228 dimerization interface [polypeptide binding]; other site 869303002229 ligand binding site [chemical binding]; other site 869303002230 sodium binding site [ion binding]; other site 869303002232 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 869303002233 Mga helix-turn-helix domain; Region: Mga; pfam05043 869303002234 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 869303002235 Predicted membrane protein [Function unknown]; Region: COG2261 869303002236 Small integral membrane protein [Function unknown]; Region: COG5547 869303002237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869303002238 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869303002239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303002240 Coenzyme A binding pocket [chemical binding]; other site 869303002241 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 869303002242 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 869303002243 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 869303002244 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869303002245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303002246 non-specific DNA binding site [nucleotide binding]; other site 869303002247 salt bridge; other site 869303002248 sequence-specific DNA binding site [nucleotide binding]; other site 869303002249 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 869303002250 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 869303002251 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 869303002252 substrate binding site [chemical binding]; other site 869303002253 active site 869303002254 catalytic residues [active] 869303002255 heterodimer interface [polypeptide binding]; other site 869303002256 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 869303002257 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 869303002258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303002259 catalytic residue [active] 869303002260 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 869303002261 active site 869303002262 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 869303002263 active site 869303002264 ribulose/triose binding site [chemical binding]; other site 869303002265 phosphate binding site [ion binding]; other site 869303002266 substrate (anthranilate) binding pocket [chemical binding]; other site 869303002267 product (indole) binding pocket [chemical binding]; other site 869303002268 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 869303002269 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869303002270 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869303002271 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 869303002272 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869303002273 glutamine binding [chemical binding]; other site 869303002274 catalytic triad [active] 869303002275 anthranilate synthase component I; Provisional; Region: PRK13570 869303002276 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 869303002277 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869303002278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869303002279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869303002280 DNA binding site [nucleotide binding] 869303002281 domain linker motif; other site 869303002282 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 869303002283 putative dimerization interface [polypeptide binding]; other site 869303002284 putative ligand binding site [chemical binding]; other site 869303002285 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 869303002286 MgtC family; Region: MgtC; pfam02308 869303002287 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 869303002288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002289 dimer interface [polypeptide binding]; other site 869303002290 conserved gate region; other site 869303002291 putative PBP binding loops; other site 869303002292 ABC-ATPase subunit interface; other site 869303002293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002294 putative PBP binding loops; other site 869303002295 dimer interface [polypeptide binding]; other site 869303002296 ABC-ATPase subunit interface; other site 869303002297 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869303002298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303002299 Walker A/P-loop; other site 869303002300 ATP binding site [chemical binding]; other site 869303002301 Q-loop/lid; other site 869303002302 ABC transporter signature motif; other site 869303002303 Walker B; other site 869303002304 D-loop; other site 869303002305 H-loop/switch region; other site 869303002306 TOBE domain; Region: TOBE; pfam03459 869303002307 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 869303002308 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869303002309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 869303002310 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 869303002312 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869303002313 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 869303002314 Pectate lyase; Region: Pec_lyase_C; cl01593 869303002315 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 869303002316 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 869303002317 inhibitor-cofactor binding pocket; inhibition site 869303002318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303002319 catalytic residue [active] 869303002320 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 869303002321 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869303002322 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869303002323 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869303002324 Walker A/P-loop; other site 869303002325 ATP binding site [chemical binding]; other site 869303002326 Q-loop/lid; other site 869303002327 ABC transporter signature motif; other site 869303002328 Walker B; other site 869303002329 D-loop; other site 869303002330 H-loop/switch region; other site 869303002331 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869303002332 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 869303002333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303002334 Walker A/P-loop; other site 869303002335 ATP binding site [chemical binding]; other site 869303002336 Q-loop/lid; other site 869303002337 ABC transporter signature motif; other site 869303002338 Walker B; other site 869303002339 D-loop; other site 869303002340 H-loop/switch region; other site 869303002342 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 869303002343 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 869303002344 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 869303002345 active site 869303002346 putative catalytic site [active] 869303002347 DNA binding site [nucleotide binding] 869303002348 putative phosphate binding site [ion binding]; other site 869303002349 metal binding site A [ion binding]; metal-binding site 869303002350 AP binding site [nucleotide binding]; other site 869303002351 metal binding site B [ion binding]; metal-binding site 869303002352 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869303002353 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869303002354 active site 869303002355 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303002356 active site 869303002357 xanthine permease; Region: pbuX; TIGR03173 869303002358 Sulfate transporter family; Region: Sulfate_transp; pfam00916 869303002359 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 869303002360 Dam-replacing family; Region: DRP; pfam06044 869303002361 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 869303002362 CoenzymeA binding site [chemical binding]; other site 869303002363 subunit interaction site [polypeptide binding]; other site 869303002364 PHB binding site; other site 869303002365 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 869303002366 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 869303002367 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 869303002368 galactokinase; Provisional; Region: PRK05322 869303002369 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 869303002370 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869303002371 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869303002372 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 869303002373 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869303002374 DNA binding site [nucleotide binding] 869303002375 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 869303002376 putative dimerization interface [polypeptide binding]; other site 869303002377 putative ligand binding site [chemical binding]; other site 869303002378 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 869303002379 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869303002380 catalytic Zn binding site [ion binding]; other site 869303002381 NAD(P) binding site [chemical binding]; other site 869303002382 structural Zn binding site [ion binding]; other site 869303002383 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 869303002384 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 869303002385 DNA binding residues [nucleotide binding] 869303002386 putative dimer interface [polypeptide binding]; other site 869303002387 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 869303002388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869303002389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869303002390 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 869303002391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002392 dimer interface [polypeptide binding]; other site 869303002393 conserved gate region; other site 869303002394 ABC-ATPase subunit interface; other site 869303002395 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 869303002396 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 869303002397 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869303002398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303002399 Walker A/P-loop; other site 869303002400 ATP binding site [chemical binding]; other site 869303002401 Q-loop/lid; other site 869303002402 ABC transporter signature motif; other site 869303002403 Walker B; other site 869303002404 D-loop; other site 869303002405 H-loop/switch region; other site 869303002406 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 869303002407 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 869303002408 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869303002409 Enterocin A Immunity; Region: EntA_Immun; pfam08951 869303002410 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869303002411 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 869303002412 oligomer interface [polypeptide binding]; other site 869303002413 active site 869303002414 metal binding site [ion binding]; metal-binding site 869303002415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869303002416 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 869303002417 NAD(P) binding site [chemical binding]; other site 869303002418 active site 869303002419 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869303002420 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869303002421 ABC-ATPase subunit interface; other site 869303002422 dimer interface [polypeptide binding]; other site 869303002423 putative PBP binding regions; other site 869303002424 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869303002425 ABC-ATPase subunit interface; other site 869303002426 dimer interface [polypeptide binding]; other site 869303002427 putative PBP binding regions; other site 869303002428 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 869303002429 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869303002430 Walker A/P-loop; other site 869303002431 ATP binding site [chemical binding]; other site 869303002432 Q-loop/lid; other site 869303002433 ABC transporter signature motif; other site 869303002434 Walker B; other site 869303002435 D-loop; other site 869303002436 H-loop/switch region; other site 869303002437 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 869303002438 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 869303002439 putative ligand binding residues [chemical binding]; other site 869303002440 hypothetical protein; Validated; Region: PRK00041 869303002441 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869303002442 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869303002443 RNA binding surface [nucleotide binding]; other site 869303002444 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 869303002445 active site 869303002446 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 869303002447 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 869303002448 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 869303002449 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869303002450 DNA binding site [nucleotide binding] 869303002451 Int/Topo IB signature motif; other site 869303002452 active site 869303002453 catalytic residues [active] 869303002454 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 869303002455 FOG: CBS domain [General function prediction only]; Region: COG0517 869303002456 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 869303002457 active site 869303002458 metal binding site [ion binding]; metal-binding site 869303002459 homotetramer interface [polypeptide binding]; other site 869303002460 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 869303002461 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 869303002462 active site 869303002463 dimerization interface [polypeptide binding]; other site 869303002464 glutamate racemase; Provisional; Region: PRK00865 869303002465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 869303002466 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869303002467 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869303002468 Ca binding site [ion binding]; other site 869303002469 active site 869303002470 catalytic site [active] 869303002471 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 869303002472 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869303002473 active site turn [active] 869303002474 phosphorylation site [posttranslational modification] 869303002475 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869303002476 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 869303002477 HPr interaction site; other site 869303002478 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869303002479 active site 869303002480 phosphorylation site [posttranslational modification] 869303002481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869303002482 DNA-binding site [nucleotide binding]; DNA binding site 869303002483 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 869303002484 UTRA domain; Region: UTRA; pfam07702 869303002486 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869303002487 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869303002488 Walker A/P-loop; other site 869303002489 ATP binding site [chemical binding]; other site 869303002490 Q-loop/lid; other site 869303002491 ABC transporter signature motif; other site 869303002492 Walker B; other site 869303002493 D-loop; other site 869303002494 H-loop/switch region; other site 869303002495 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869303002496 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 869303002497 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869303002498 Walker A/P-loop; other site 869303002499 ATP binding site [chemical binding]; other site 869303002500 Q-loop/lid; other site 869303002501 ABC transporter signature motif; other site 869303002502 Walker B; other site 869303002503 D-loop; other site 869303002504 H-loop/switch region; other site 869303002505 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869303002506 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 869303002507 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869303002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002509 dimer interface [polypeptide binding]; other site 869303002510 conserved gate region; other site 869303002511 putative PBP binding loops; other site 869303002512 ABC-ATPase subunit interface; other site 869303002513 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869303002514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002515 dimer interface [polypeptide binding]; other site 869303002516 conserved gate region; other site 869303002517 putative PBP binding loops; other site 869303002518 ABC-ATPase subunit interface; other site 869303002519 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869303002520 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869303002521 peptide binding site [polypeptide binding]; other site 869303002522 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 869303002523 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 869303002525 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869303002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002527 dimer interface [polypeptide binding]; other site 869303002528 conserved gate region; other site 869303002529 putative PBP binding loops; other site 869303002530 ABC-ATPase subunit interface; other site 869303002531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002532 dimer interface [polypeptide binding]; other site 869303002533 conserved gate region; other site 869303002534 putative PBP binding loops; other site 869303002535 ABC-ATPase subunit interface; other site 869303002536 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869303002537 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869303002538 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 869303002539 Melibiase; Region: Melibiase; pfam02065 869303002540 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 869303002541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869303002542 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869303002543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869303002544 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 869303002545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869303002546 DNA-binding site [nucleotide binding]; DNA binding site 869303002547 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 869303002548 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 869303002550 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869303002551 TRAM domain; Region: TRAM; cl01282 869303002552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303002553 S-adenosylmethionine binding site [chemical binding]; other site 869303002554 recombination regulator RecX; Provisional; Region: recX; PRK14135 869303002555 hypothetical protein; Provisional; Region: PRK13662 869303002557 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869303002558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303002559 S-adenosylmethionine binding site [chemical binding]; other site 869303002560 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 869303002561 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 869303002562 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 869303002563 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 869303002564 ring oligomerisation interface [polypeptide binding]; other site 869303002565 ATP/Mg binding site [chemical binding]; other site 869303002566 stacking interactions; other site 869303002567 hinge regions; other site 869303002568 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 869303002569 oligomerisation interface [polypeptide binding]; other site 869303002570 mobile loop; other site 869303002571 roof hairpin; other site 869303002572 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869303002573 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869303002574 dimer interface [polypeptide binding]; other site 869303002575 ssDNA binding site [nucleotide binding]; other site 869303002576 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869303002577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869303002578 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 869303002579 NAD(P) binding site [chemical binding]; other site 869303002580 active site 869303002581 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869303002582 putative tRNA-binding site [nucleotide binding]; other site 869303002583 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869303002584 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869303002585 catalytic residues [active] 869303002586 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869303002587 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 869303002588 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869303002589 LytTr DNA-binding domain; Region: LytTR; pfam04397 869303002590 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 869303002591 active site 869303002592 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869303002593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898 869303002594 hypothetical protein; Provisional; Region: PRK12378 869303002595 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 869303002596 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 869303002597 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 869303002599 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 869303002600 putative active site [active] 869303002601 putative metal binding site [ion binding]; other site 869303002602 oligomer interface [polypeptide binding]; other site 869303002603 catalytic site [active] 869303002604 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869303002605 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 869303002606 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869303002607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303002608 Walker A/P-loop; other site 869303002609 ATP binding site [chemical binding]; other site 869303002610 Q-loop/lid; other site 869303002611 ABC transporter signature motif; other site 869303002612 Walker B; other site 869303002613 D-loop; other site 869303002614 H-loop/switch region; other site 869303002615 TOBE domain; Region: TOBE_2; pfam08402 869303002616 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 869303002617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869303002618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303002619 dimer interface [polypeptide binding]; other site 869303002620 conserved gate region; other site 869303002621 putative PBP binding loops; other site 869303002622 ABC-ATPase subunit interface; other site 869303002623 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 869303002624 MgtC family; Region: MgtC; pfam02308 869303002625 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 869303002626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303002627 motif II; other site 869303002628 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869303002629 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869303002630 DNA binding site [nucleotide binding] 869303002631 domain linker motif; other site 869303002632 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869303002633 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869303002634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 869303002635 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869303002636 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 869303002637 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869303002638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303002639 non-specific DNA binding site [nucleotide binding]; other site 869303002640 salt bridge; other site 869303002641 sequence-specific DNA binding site [nucleotide binding]; other site 869303002642 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869303002643 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869303002644 amidase catalytic site [active] 869303002645 Zn binding residues [ion binding]; other site 869303002646 substrate binding site [chemical binding]; other site 869303002647 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303002648 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303002649 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869303002650 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 869303002651 recombinase A; Provisional; Region: recA; PRK09354 869303002652 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 869303002653 hexamer interface [polypeptide binding]; other site 869303002654 Walker A motif; other site 869303002655 ATP binding site [chemical binding]; other site 869303002656 Walker B motif; other site 869303002657 competence damage-inducible protein A; Provisional; Region: PRK00549 869303002658 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 869303002659 putative MPT binding site; other site 869303002660 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 869303002661 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869303002662 putative acetyltransferase YhhY; Provisional; Region: PRK10140 869303002663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303002664 Coenzyme A binding pocket [chemical binding]; other site 869303002665 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 869303002666 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869303002667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303002668 non-specific DNA binding site [nucleotide binding]; other site 869303002669 salt bridge; other site 869303002670 sequence-specific DNA binding site [nucleotide binding]; other site 869303002671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869303002672 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869303002673 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869303002674 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869303002675 Walker A/P-loop; other site 869303002676 ATP binding site [chemical binding]; other site 869303002677 Q-loop/lid; other site 869303002678 ABC transporter signature motif; other site 869303002679 Walker B; other site 869303002680 D-loop; other site 869303002681 H-loop/switch region; other site 869303002682 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 869303002683 active site 869303002684 multimer interface [polypeptide binding]; other site 869303002685 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 869303002686 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 869303002687 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 869303002688 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 869303002689 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 869303002690 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869303002691 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 869303002692 G-loop; other site 869303002693 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869303002694 DNA binding site [nucleotide binding] 869303002695 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 869303002696 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 869303002697 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869303002698 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 869303002699 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869303002700 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 869303002701 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869303002702 RPB1 interaction site [polypeptide binding]; other site 869303002703 RPB10 interaction site [polypeptide binding]; other site 869303002704 RPB11 interaction site [polypeptide binding]; other site 869303002705 RPB3 interaction site [polypeptide binding]; other site 869303002706 RPB12 interaction site [polypeptide binding]; other site 869303002707 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 869303002708 Domain of unknown function DUF21; Region: DUF21; pfam01595 869303002709 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869303002710 Transporter associated domain; Region: CorC_HlyC; smart01091 869303002711 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 869303002712 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 869303002713 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 869303002714 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869303002715 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869303002716 hinge; other site 869303002717 active site 869303002718 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 869303002719 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 869303002720 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 869303002721 protein binding site [polypeptide binding]; other site 869303002722 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 869303002723 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 869303002724 active site 869303002725 (T/H)XGH motif; other site 869303002726 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 869303002727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303002728 S-adenosylmethionine binding site [chemical binding]; other site 869303002729 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 869303002730 dimer interface [polypeptide binding]; other site 869303002731 active site 869303002732 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869303002733 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 869303002734 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869303002735 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 869303002736 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869303002737 acylphosphatase; Provisional; Region: PRK14434 869303002738 OxaA-like protein precursor; Provisional; Region: PRK02463 869303002739 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869303002740 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 869303002741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869303002742 FeS/SAM binding site; other site 869303002743 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 869303002744 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 869303002745 active site 869303002746 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869303002747 substrate binding site [chemical binding]; other site 869303002748 catalytic residues [active] 869303002749 dimer interface [polypeptide binding]; other site 869303002750 pur operon repressor; Provisional; Region: PRK09213 869303002751 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 869303002752 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303002753 active site 869303002754 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 869303002755 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 869303002756 generic binding surface II; other site 869303002757 generic binding surface I; other site 869303002758 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869303002759 Zn2+ binding site [ion binding]; other site 869303002760 Mg2+ binding site [ion binding]; other site 869303002761 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 869303002762 RmuC family; Region: RmuC; pfam02646 869303002763 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 869303002764 Thiamine pyrophosphokinase; Region: TPK; cd07995 869303002765 active site 869303002766 dimerization interface [polypeptide binding]; other site 869303002767 thiamine binding site [chemical binding]; other site 869303002768 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 869303002769 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869303002770 substrate binding site [chemical binding]; other site 869303002771 hexamer interface [polypeptide binding]; other site 869303002772 metal binding site [ion binding]; metal-binding site 869303002773 GTPase RsgA; Reviewed; Region: PRK00098 869303002774 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 869303002775 RNA binding site [nucleotide binding]; other site 869303002776 homodimer interface [polypeptide binding]; other site 869303002777 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 869303002778 GTPase/Zn-binding domain interface [polypeptide binding]; other site 869303002779 GTP/Mg2+ binding site [chemical binding]; other site 869303002780 G4 box; other site 869303002781 G5 box; other site 869303002782 G1 box; other site 869303002783 Switch I region; other site 869303002784 G2 box; other site 869303002785 G3 box; other site 869303002786 Switch II region; other site 869303002787 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 869303002788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303002789 S-adenosylmethionine binding site [chemical binding]; other site 869303002790 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869303002791 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869303002792 Walker A/P-loop; other site 869303002793 ATP binding site [chemical binding]; other site 869303002794 Q-loop/lid; other site 869303002795 ABC transporter signature motif; other site 869303002796 Walker B; other site 869303002797 D-loop; other site 869303002798 H-loop/switch region; other site 869303002799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869303002800 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869303002801 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869303002802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303002803 non-specific DNA binding site [nucleotide binding]; other site 869303002804 salt bridge; other site 869303002805 sequence-specific DNA binding site [nucleotide binding]; other site 869303002806 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 869303002807 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 869303002808 putative active site [active] 869303002809 putative metal binding site [ion binding]; other site 869303002810 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 869303002811 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869303002812 active site 869303002813 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869303002814 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 869303002815 Helix-turn-helix domain; Region: HTH_38; pfam13936 869303002816 Integrase core domain; Region: rve; pfam00665 869303002817 aminotransferase AlaT; Validated; Region: PRK09265 869303002818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869303002819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303002820 homodimer interface [polypeptide binding]; other site 869303002821 catalytic residue [active] 869303002822 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869303002823 Ligand Binding Site [chemical binding]; other site 869303002824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303002825 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869303002826 active site 869303002827 motif I; other site 869303002828 motif II; other site 869303002829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303002830 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 869303002831 putative nucleotide binding site [chemical binding]; other site 869303002832 putative metal binding site [ion binding]; other site 869303002833 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 869303002834 active site 869303002835 homotetramer interface [polypeptide binding]; other site 869303002836 homodimer interface [polypeptide binding]; other site 869303002837 catabolite control protein A; Region: ccpA; TIGR01481 869303002838 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869303002839 DNA binding site [nucleotide binding] 869303002840 domain linker motif; other site 869303002841 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 869303002842 dimerization interface [polypeptide binding]; other site 869303002843 effector binding site; other site 869303002844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869303002845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303002846 active site 869303002847 phosphorylation site [posttranslational modification] 869303002848 intermolecular recognition site; other site 869303002849 dimerization interface [polypeptide binding]; other site 869303002850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869303002851 DNA binding residues [nucleotide binding] 869303002852 dimerization interface [polypeptide binding]; other site 869303002853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 869303002854 Histidine kinase; Region: HisKA_3; pfam07730 869303002855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303002856 ATP binding site [chemical binding]; other site 869303002857 Mg2+ binding site [ion binding]; other site 869303002858 G-X-G motif; other site 869303002859 ABC-2 type transporter; Region: ABC2_membrane; cl17235 869303002860 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869303002861 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869303002862 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869303002863 Walker A/P-loop; other site 869303002864 ATP binding site [chemical binding]; other site 869303002865 Q-loop/lid; other site 869303002866 ABC transporter signature motif; other site 869303002867 Walker B; other site 869303002868 D-loop; other site 869303002869 H-loop/switch region; other site 869303002870 manually curated to include N-terminal signal sequence 869303002871 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 869303002872 Helix-turn-helix domain; Region: HTH_38; pfam13936 869303002873 Integrase core domain; Region: rve; pfam00665 869303002874 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 869303002875 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 869303002876 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 869303002877 putative homodimer interface [polypeptide binding]; other site 869303002878 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 869303002879 heterodimer interface [polypeptide binding]; other site 869303002880 homodimer interface [polypeptide binding]; other site 869303002881 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 869303002882 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 869303002883 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869303002884 Transglycosylase; Region: Transgly; pfam00912 869303002885 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869303002886 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869303002887 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869303002888 active site 869303002889 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 869303002890 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 869303002891 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869303002894 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 869303002895 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 869303002896 dimerization interface [polypeptide binding]; other site 869303002897 active site 869303002898 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 869303002899 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869303002901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 869303002902 Walker A/P-loop; other site 869303002903 ATP binding site [chemical binding]; other site 869303002904 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869303002905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869303002906 DNA-binding site [nucleotide binding]; DNA binding site 869303002907 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 869303002908 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869303002909 beta-galactosidase; Region: BGL; TIGR03356 869303002910 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869303002911 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869303002912 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869303002913 active site 869303002914 P-loop; other site 869303002915 phosphorylation site [posttranslational modification] 869303002916 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869303002917 methionine cluster; other site 869303002918 active site 869303002919 phosphorylation site [posttranslational modification] 869303002920 metal binding site [ion binding]; metal-binding site 869303002921 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 869303002922 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 869303002923 putative catalytic cysteine [active] 869303002924 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 869303002925 putative active site [active] 869303002926 metal binding site [ion binding]; metal-binding site 869303002927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 869303002928 MORN repeat; Region: MORN; cl14787 869303002929 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 869303002930 Low molecular weight phosphatase family; Region: LMWPc; cd00115 869303002931 active site 869303002932 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 869303002933 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 869303002934 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869303002935 TPP-binding site [chemical binding]; other site 869303002936 dimer interface [polypeptide binding]; other site 869303002937 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869303002938 PYR/PP interface [polypeptide binding]; other site 869303002939 dimer interface [polypeptide binding]; other site 869303002940 TPP binding site [chemical binding]; other site 869303002941 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869303002942 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 869303002943 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869303002944 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869303002945 PRD domain; Region: PRD; pfam00874 869303002946 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869303002947 active site 869303002948 P-loop; other site 869303002949 phosphorylation site [posttranslational modification] 869303002950 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 869303002951 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 869303002952 intersubunit interface [polypeptide binding]; other site 869303002953 active site 869303002954 Zn2+ binding site [ion binding]; other site 869303002955 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 869303002956 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 869303002957 AP (apurinic/apyrimidinic) site pocket; other site 869303002958 DNA interaction; other site 869303002959 Metal-binding active site; metal-binding site 869303002960 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 869303002961 active site 869303002962 dimer interface [polypeptide binding]; other site 869303002963 magnesium binding site [ion binding]; other site 869303002964 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869303002965 active site 869303002966 phosphorylation site [posttranslational modification] 869303002967 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869303002968 active site 869303002969 P-loop; other site 869303002970 phosphorylation site [posttranslational modification] 869303002971 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 869303002972 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 869303002973 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 869303002974 G-X-X-G motif; other site 869303002975 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 869303002976 RxxxH motif; other site 869303002977 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 869303002978 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869303002979 ribonuclease P; Reviewed; Region: rnpA; PRK00499 869303002980 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 869303002981 propionate/acetate kinase; Provisional; Region: PRK12379 869303002982 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 869303002983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303002984 S-adenosylmethionine binding site [chemical binding]; other site 869303002986 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 869303002987 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 869303002988 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 869303002989 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 869303002990 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 869303002991 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869303002992 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 869303002993 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869303002994 Walker A motif; other site 869303002995 ATP binding site [chemical binding]; other site 869303002996 Walker B motif; other site 869303002997 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 869303002998 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 869303002999 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869303003000 catalytic Zn binding site [ion binding]; other site 869303003001 structural Zn binding site [ion binding]; other site 869303003002 NAD(P) binding site [chemical binding]; other site 869303003003 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 869303003004 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 869303003005 active site 869303003006 dimer interface [polypeptide binding]; other site 869303003007 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 869303003008 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 869303003009 catalytic triad [active] 869303003010 catalytic triad [active] 869303003011 oxyanion hole [active] 869303003012 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 869303003013 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 869303003014 Predicted integral membrane protein [Function unknown]; Region: COG5523 869303003016 Predicted membrane protein [Function unknown]; Region: COG3759 869303003017 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869303003018 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869303003019 putative DNA binding site [nucleotide binding]; other site 869303003020 putative Zn2+ binding site [ion binding]; other site 869303003021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869303003022 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869303003023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303003024 motif II; other site 869303003025 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869303003026 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 869303003027 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 869303003028 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 869303003029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303003030 catalytic residue [active] 869303003031 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 869303003032 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869303003033 active site 869303003034 catalytic motif [active] 869303003035 Zn binding site [ion binding]; other site 869303003036 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 869303003037 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869303003038 active site 869303003039 HIGH motif; other site 869303003040 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869303003041 active site 869303003042 KMSKS motif; other site 869303003043 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 869303003044 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 869303003045 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 869303003046 active site 869303003047 dimer interface [polypeptide binding]; other site 869303003048 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 869303003049 dimer interface [polypeptide binding]; other site 869303003050 active site 869303003051 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 869303003052 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 869303003053 catalytic triad [active] 869303003054 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869303003055 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869303003056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303003057 Walker A/P-loop; other site 869303003058 ATP binding site [chemical binding]; other site 869303003059 Q-loop/lid; other site 869303003060 ABC transporter signature motif; other site 869303003061 Walker B; other site 869303003062 D-loop; other site 869303003063 H-loop/switch region; other site 869303003065 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869303003066 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869303003067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303003068 Walker A/P-loop; other site 869303003069 ATP binding site [chemical binding]; other site 869303003070 Q-loop/lid; other site 869303003071 ABC transporter signature motif; other site 869303003072 Walker B; other site 869303003073 D-loop; other site 869303003074 H-loop/switch region; other site 869303003075 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 869303003076 MutS domain I; Region: MutS_I; pfam01624 869303003077 MutS domain II; Region: MutS_II; pfam05188 869303003078 MutS domain III; Region: MutS_III; pfam05192 869303003079 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 869303003080 Walker A/P-loop; other site 869303003081 ATP binding site [chemical binding]; other site 869303003082 Q-loop/lid; other site 869303003083 ABC transporter signature motif; other site 869303003084 Walker B; other site 869303003085 D-loop; other site 869303003086 H-loop/switch region; other site 869303003087 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869303003088 arginine repressor; Region: argR_whole; TIGR01529 869303003089 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869303003090 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 869303003091 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 869303003092 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 869303003093 active site 869303003094 HIGH motif; other site 869303003095 KMSK motif region; other site 869303003096 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 869303003097 tRNA binding surface [nucleotide binding]; other site 869303003098 anticodon binding site; other site 869303003100 Uncharacterized conserved protein [Function unknown]; Region: COG3542 869303003101 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869303003102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303003103 active site 869303003104 phosphorylation site [posttranslational modification] 869303003105 intermolecular recognition site; other site 869303003106 dimerization interface [polypeptide binding]; other site 869303003107 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869303003108 DNA binding site [nucleotide binding] 869303003109 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 869303003110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869303003111 dimer interface [polypeptide binding]; other site 869303003112 phosphorylation site [posttranslational modification] 869303003113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303003114 ATP binding site [chemical binding]; other site 869303003115 G-X-G motif; other site 869303003116 PBP superfamily domain; Region: PBP_like_2; cl17296 869303003117 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 869303003118 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 869303003119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303003120 dimer interface [polypeptide binding]; other site 869303003121 conserved gate region; other site 869303003122 putative PBP binding loops; other site 869303003123 ABC-ATPase subunit interface; other site 869303003124 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 869303003125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303003126 dimer interface [polypeptide binding]; other site 869303003127 conserved gate region; other site 869303003128 putative PBP binding loops; other site 869303003129 ABC-ATPase subunit interface; other site 869303003130 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 869303003131 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869303003132 Walker A/P-loop; other site 869303003133 ATP binding site [chemical binding]; other site 869303003134 Q-loop/lid; other site 869303003135 ABC transporter signature motif; other site 869303003136 Walker B; other site 869303003137 D-loop; other site 869303003138 H-loop/switch region; other site 869303003139 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869303003140 PhoU domain; Region: PhoU; pfam01895 869303003141 PhoU domain; Region: PhoU; pfam01895 869303003143 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869303003144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303003145 non-specific DNA binding site [nucleotide binding]; other site 869303003146 salt bridge; other site 869303003147 sequence-specific DNA binding site [nucleotide binding]; other site 869303003148 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 869303003149 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869303003150 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 869303003151 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869303003152 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869303003153 active site 869303003154 tetramer interface; other site 869303003155 Rhomboid family; Region: Rhomboid; pfam01694 869303003156 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 869303003157 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 869303003158 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869303003159 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 869303003160 metal binding site [ion binding]; metal-binding site 869303003161 putative dimer interface [polypeptide binding]; other site 869303003162 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 869303003163 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 869303003164 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 869303003165 trimer interface [polypeptide binding]; other site 869303003166 active site 869303003167 substrate binding site [chemical binding]; other site 869303003168 CoA binding site [chemical binding]; other site 869303003169 EamA-like transporter family; Region: EamA; pfam00892 869303003170 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869303003171 Transglycosylase; Region: Transgly; pfam00912 869303003172 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869303003173 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 869303003174 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 869303003175 active site 869303003176 HIGH motif; other site 869303003177 dimer interface [polypeptide binding]; other site 869303003178 KMSKS motif; other site 869303003179 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869303003180 RNA binding surface [nucleotide binding]; other site 869303003181 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 869303003182 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869303003183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303003184 motif II; other site 869303003185 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 869303003186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303003187 S-adenosylmethionine binding site [chemical binding]; other site 869303003188 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 869303003189 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869303003190 4-alpha-glucanotransferase; Provisional; Region: PRK14508 869303003191 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 869303003192 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869303003193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303003194 dimer interface [polypeptide binding]; other site 869303003195 conserved gate region; other site 869303003196 putative PBP binding loops; other site 869303003197 ABC-ATPase subunit interface; other site 869303003198 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869303003199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303003200 dimer interface [polypeptide binding]; other site 869303003201 conserved gate region; other site 869303003202 putative PBP binding loops; other site 869303003203 ABC-ATPase subunit interface; other site 869303003204 Predicted integral membrane protein [Function unknown]; Region: COG5521 869303003205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869303003206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869303003207 DNA binding site [nucleotide binding] 869303003208 domain linker motif; other site 869303003209 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 869303003210 putative dimerization interface [polypeptide binding]; other site 869303003211 putative ligand binding site [chemical binding]; other site 869303003212 Uncharacterized conserved protein [Function unknown]; Region: COG1284 869303003213 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869303003214 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869303003215 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869303003216 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 869303003217 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 869303003218 dimer interface [polypeptide binding]; other site 869303003219 anticodon binding site; other site 869303003220 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869303003221 homodimer interface [polypeptide binding]; other site 869303003222 motif 1; other site 869303003223 active site 869303003224 motif 2; other site 869303003225 GAD domain; Region: GAD; pfam02938 869303003226 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869303003227 motif 3; other site 869303003228 CAAX protease self-immunity; Region: Abi; pfam02517 869303003229 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 869303003230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303003231 non-specific DNA binding site [nucleotide binding]; other site 869303003232 salt bridge; other site 869303003233 sequence-specific DNA binding site [nucleotide binding]; other site 869303003234 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 869303003235 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 869303003236 dimer interface [polypeptide binding]; other site 869303003237 motif 1; other site 869303003238 active site 869303003239 motif 2; other site 869303003240 motif 3; other site 869303003241 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 869303003242 anticodon binding site; other site 869303003243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303003244 non-specific DNA binding site [nucleotide binding]; other site 869303003245 salt bridge; other site 869303003246 sequence-specific DNA binding site [nucleotide binding]; other site 869303003247 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869303003248 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869303003249 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 869303003250 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 869303003251 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869303003252 PYR/PP interface [polypeptide binding]; other site 869303003253 dimer interface [polypeptide binding]; other site 869303003254 TPP binding site [chemical binding]; other site 869303003255 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869303003256 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869303003257 TPP-binding site [chemical binding]; other site 869303003258 dimer interface [polypeptide binding]; other site 869303003259 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 869303003260 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869303003261 active site 869303003262 P-loop; other site 869303003263 phosphorylation site [posttranslational modification] 869303003264 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869303003265 PRD domain; Region: PRD; pfam00874 869303003266 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869303003267 active site 869303003268 P-loop; other site 869303003269 phosphorylation site [posttranslational modification] 869303003270 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869303003271 active site 869303003272 phosphorylation site [posttranslational modification] 869303003273 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869303003274 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 869303003275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 869303003276 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 869303003277 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869303003278 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 869303003279 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 869303003280 putative active site [active] 869303003281 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869303003282 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869303003283 nucleotide binding site [chemical binding]; other site 869303003284 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 869303003285 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 869303003286 active site 869303003287 metal binding site [ion binding]; metal-binding site 869303003288 homodimer interface [polypeptide binding]; other site 869303003289 catalytic site [active] 869303003290 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 869303003291 Uncharacterized conserved protein [Function unknown]; Region: COG3538 869303003292 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 869303003293 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 869303003294 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 869303003295 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 869303003296 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 869303003297 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869303003298 arginine deiminase; Provisional; Region: PRK01388 869303003299 ornithine carbamoyltransferase; Validated; Region: PRK02102 869303003300 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869303003301 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869303003302 carbamate kinase; Reviewed; Region: PRK12686 869303003303 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869303003304 putative substrate binding site [chemical binding]; other site 869303003305 nucleotide binding site [chemical binding]; other site 869303003306 nucleotide binding site [chemical binding]; other site 869303003307 homodimer interface [polypeptide binding]; other site 869303003308 Predicted membrane protein [Function unknown]; Region: COG1288 869303003309 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 869303003310 hypothetical protein; Provisional; Region: PRK07205 869303003311 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 869303003312 active site 869303003313 metal binding site [ion binding]; metal-binding site 869303003315 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869303003316 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 869303003317 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 869303003318 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 869303003319 dimer interface [polypeptide binding]; other site 869303003320 active site 869303003321 metal binding site [ion binding]; metal-binding site 869303003322 L-fucose isomerase; Provisional; Region: fucI; PRK10991 869303003323 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 869303003324 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869303003325 trimer interface [polypeptide binding]; other site 869303003326 substrate binding site [chemical binding]; other site 869303003327 Mn binding site [ion binding]; other site 869303003328 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 869303003329 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 869303003330 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 869303003331 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 869303003332 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 869303003333 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869303003334 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869303003335 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869303003336 active site 869303003337 phosphorylation site [posttranslational modification] 869303003338 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869303003339 active pocket/dimerization site; other site 869303003340 active site 869303003341 phosphorylation site [posttranslational modification] 869303003342 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 869303003343 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 869303003344 intersubunit interface [polypeptide binding]; other site 869303003345 active site 869303003346 Zn2+ binding site [ion binding]; other site 869303003348 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869303003349 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 869303003350 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869303003351 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869303003352 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 869303003353 metal binding site [ion binding]; metal-binding site 869303003354 YodA lipocalin-like domain; Region: YodA; pfam09223 869303003355 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869303003356 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869303003357 ABC-ATPase subunit interface; other site 869303003358 dimer interface [polypeptide binding]; other site 869303003359 putative PBP binding regions; other site 869303003360 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869303003361 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869303003362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869303003363 putative DNA binding site [nucleotide binding]; other site 869303003364 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 869303003365 DltD N-terminal region; Region: DltD_N; pfam04915 869303003366 DltD central region; Region: DltD_M; pfam04918 869303003367 DltD C-terminal region; Region: DltD_C; pfam04914 869303003368 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 869303003369 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 869303003370 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 869303003371 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 869303003372 acyl-activating enzyme (AAE) consensus motif; other site 869303003373 AMP binding site [chemical binding]; other site 869303003374 H+ Antiporter protein; Region: 2A0121; TIGR00900 869303003375 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 869303003376 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 869303003377 putative active site [active] 869303003378 putative NTP binding site [chemical binding]; other site 869303003379 putative nucleic acid binding site [nucleotide binding]; other site 869303003380 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 869303003381 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869303003382 amphipathic channel; other site 869303003383 Asn-Pro-Ala signature motifs; other site 869303003384 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 869303003385 glycerol kinase; Provisional; Region: glpK; PRK00047 869303003386 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 869303003387 N- and C-terminal domain interface [polypeptide binding]; other site 869303003388 active site 869303003389 MgATP binding site [chemical binding]; other site 869303003390 catalytic site [active] 869303003391 metal binding site [ion binding]; metal-binding site 869303003392 glycerol binding site [chemical binding]; other site 869303003393 homotetramer interface [polypeptide binding]; other site 869303003394 homodimer interface [polypeptide binding]; other site 869303003395 FBP binding site [chemical binding]; other site 869303003396 protein IIAGlc interface [polypeptide binding]; other site 869303003397 Mga helix-turn-helix domain; Region: Mga; pfam05043 869303003398 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 869303003399 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 869303003400 dimerization interface [polypeptide binding]; other site 869303003401 domain crossover interface; other site 869303003402 redox-dependent activation switch; other site 869303003403 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 869303003404 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869303003405 FMN binding site [chemical binding]; other site 869303003406 active site 869303003407 catalytic residues [active] 869303003408 substrate binding site [chemical binding]; other site 869303003409 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869303003410 RICH domain; Region: RICH; pfam05062 869303003411 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003412 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003413 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003414 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003415 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003416 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869303003417 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003418 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 869303003420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869303003421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869303003422 dimerization interface [polypeptide binding]; other site 869303003423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869303003424 dimer interface [polypeptide binding]; other site 869303003425 phosphorylation site [posttranslational modification] 869303003426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303003427 ATP binding site [chemical binding]; other site 869303003428 Mg2+ binding site [ion binding]; other site 869303003429 G-X-G motif; other site 869303003430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869303003431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303003432 active site 869303003433 phosphorylation site [posttranslational modification] 869303003434 intermolecular recognition site; other site 869303003435 dimerization interface [polypeptide binding]; other site 869303003436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869303003437 DNA binding site [nucleotide binding] 869303003438 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869303003439 Clp amino terminal domain; Region: Clp_N; pfam02861 869303003440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303003441 Walker A motif; other site 869303003442 ATP binding site [chemical binding]; other site 869303003443 Walker B motif; other site 869303003444 arginine finger; other site 869303003445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303003446 Walker A motif; other site 869303003447 ATP binding site [chemical binding]; other site 869303003448 Walker B motif; other site 869303003449 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869303003450 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 869303003451 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 869303003452 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 869303003453 Walker A/P-loop; other site 869303003454 ATP binding site [chemical binding]; other site 869303003455 Q-loop/lid; other site 869303003456 ABC transporter signature motif; other site 869303003457 Walker B; other site 869303003458 D-loop; other site 869303003459 H-loop/switch region; other site 869303003460 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 869303003461 NMT1/THI5 like; Region: NMT1; pfam09084 869303003462 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869303003463 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 869303003464 Uncharacterized conserved protein [Function unknown]; Region: COG0011 869303003465 Surface antigen [General function prediction only]; Region: COG3942 869303003466 CHAP domain; Region: CHAP; pfam05257 869303003467 Bacterial SH3 domain; Region: SH3_5; pfam08460 869303003468 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869303003469 Bacterial SH3 domain; Region: SH3_5; pfam08460 869303003470 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 869303003472 replicative DNA helicase; Provisional; Region: PRK05748 869303003473 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 869303003474 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 869303003475 Walker A motif; other site 869303003476 ATP binding site [chemical binding]; other site 869303003477 Walker B motif; other site 869303003478 DNA binding loops [nucleotide binding] 869303003479 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 869303003480 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 869303003481 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 869303003482 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 869303003483 DHH family; Region: DHH; pfam01368 869303003484 DHHA1 domain; Region: DHHA1; pfam02272 869303003485 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 869303003486 30S subunit binding site; other site 869303003487 comF family protein; Region: comF; TIGR00201 869303003488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303003489 active site 869303003490 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 869303003491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869303003492 ATP binding site [chemical binding]; other site 869303003493 putative Mg++ binding site [ion binding]; other site 869303003494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869303003495 nucleotide binding region [chemical binding]; other site 869303003496 ATP-binding site [chemical binding]; other site 869303003497 Uncharacterized conserved protein [Function unknown]; Region: COG1739 869303003498 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 869303003499 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 869303003500 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869303003501 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869303003502 dimer interface [polypeptide binding]; other site 869303003503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303003504 catalytic residue [active] 869303003508 elongation factor Ts; Provisional; Region: tsf; PRK09377 869303003509 UBA/TS-N domain; Region: UBA; pfam00627 869303003510 Elongation factor TS; Region: EF_TS; pfam00889 869303003511 Elongation factor TS; Region: EF_TS; pfam00889 869303003512 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 869303003513 rRNA interaction site [nucleotide binding]; other site 869303003514 S8 interaction site; other site 869303003515 putative laminin-1 binding site; other site 869303003516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 869303003517 Septum formation initiator; Region: DivIC; cl17659 869303003518 Surface antigen [General function prediction only]; Region: COG3942 869303003519 CHAP domain; Region: CHAP; pfam05257 869303003520 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 869303003521 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 869303003522 rod shape-determining protein MreC; Region: MreC; pfam04085 869303003523 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869303003524 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 869303003525 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869303003526 Walker A/P-loop; other site 869303003527 ATP binding site [chemical binding]; other site 869303003528 Q-loop/lid; other site 869303003529 ABC transporter signature motif; other site 869303003530 Walker B; other site 869303003531 D-loop; other site 869303003532 H-loop/switch region; other site 869303003533 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 869303003534 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869303003535 Walker A/P-loop; other site 869303003536 ATP binding site [chemical binding]; other site 869303003537 Q-loop/lid; other site 869303003538 ABC transporter signature motif; other site 869303003539 Walker B; other site 869303003540 D-loop; other site 869303003541 H-loop/switch region; other site 869303003542 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 869303003543 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 869303003544 Helix-turn-helix domain; Region: HTH_25; pfam13413 869303003545 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 869303003546 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869303003547 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869303003548 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869303003549 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869303003550 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869303003551 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 869303003552 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 869303003553 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 869303003554 Walker A/P-loop; other site 869303003555 ATP binding site [chemical binding]; other site 869303003556 Q-loop/lid; other site 869303003557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303003558 ABC transporter signature motif; other site 869303003559 Walker B; other site 869303003560 D-loop; other site 869303003561 H-loop/switch region; other site 869303003562 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 869303003563 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869303003564 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 869303003565 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869303003566 active site 869303003567 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 869303003568 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 869303003569 active site 869303003570 HIGH motif; other site 869303003571 dimer interface [polypeptide binding]; other site 869303003572 KMSKS motif; other site 869303003573 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 869303003574 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303003575 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303003576 ABC transporter; Region: ABC_tran_2; pfam12848 869303003577 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303003578 Predicted membrane protein [Function unknown]; Region: COG4485 869303003579 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 869303003580 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 869303003581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869303003582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869303003583 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869303003584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303003585 active site 869303003586 phosphorylation site [posttranslational modification] 869303003587 intermolecular recognition site; other site 869303003588 dimerization interface [polypeptide binding]; other site 869303003589 LytTr DNA-binding domain; Region: LytTR; pfam04397 869303003590 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869303003591 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 869303003592 COMC family; Region: ComC; pfam03047 869303003593 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 869303003594 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 869303003595 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869303003596 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869303003597 protein binding site [polypeptide binding]; other site 869303003598 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 869303003599 ParB-like nuclease domain; Region: ParBc; pfam02195 869303003600 KorB domain; Region: KorB; pfam08535 869303003601 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 869303003602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303003603 Walker A motif; other site 869303003604 ATP binding site [chemical binding]; other site 869303003605 Walker B motif; other site 869303003606 arginine finger; other site 869303003607 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 869303003608 DnaA box-binding interface [nucleotide binding]; other site 869303003609 DNA polymerase III subunit beta; Validated; Region: PRK05643 869303003610 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 869303003611 putative DNA binding surface [nucleotide binding]; other site 869303003612 dimer interface [polypeptide binding]; other site 869303003613 beta-clamp/clamp loader binding surface; other site 869303003614 beta-clamp/translesion DNA polymerase binding surface; other site 869303003615 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 869303003616 GTP-binding protein YchF; Reviewed; Region: PRK09601 869303003617 YchF GTPase; Region: YchF; cd01900 869303003618 G1 box; other site 869303003619 GTP/Mg2+ binding site [chemical binding]; other site 869303003620 Switch I region; other site 869303003621 G2 box; other site 869303003622 Switch II region; other site 869303003623 G3 box; other site 869303003624 G4 box; other site 869303003625 G5 box; other site 869303003626 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 869303003627 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 869303003628 putative active site [active] 869303003629 catalytic residue [active] 869303003630 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 869303003631 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 869303003632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869303003633 ATP binding site [chemical binding]; other site 869303003634 putative Mg++ binding site [ion binding]; other site 869303003635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869303003636 nucleotide binding region [chemical binding]; other site 869303003637 ATP-binding site [chemical binding]; other site 869303003638 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 869303003639 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869303003640 RNA binding surface [nucleotide binding]; other site 869303003641 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 869303003642 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 869303003643 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 869303003644 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 869303003645 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 869303003646 Ligand Binding Site [chemical binding]; other site 869303003647 TilS substrate C-terminal domain; Region: TilS_C; smart00977 869303003648 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303003649 active site 869303003650 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 869303003651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303003652 Walker A motif; other site 869303003653 ATP binding site [chemical binding]; other site 869303003654 Walker B motif; other site 869303003655 arginine finger; other site 869303003656 Peptidase family M41; Region: Peptidase_M41; pfam01434 869303003657 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 869303003659 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 869303003660 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 869303003661 GDP-binding site [chemical binding]; other site 869303003662 ACT binding site; other site 869303003663 IMP binding site; other site 869303003664 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869303003665 active site 869303003666 catalytic residues [active] 869303003667 DNA binding site [nucleotide binding] 869303003668 Int/Topo IB signature motif; other site 869303003669 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 869303003670 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 869303003671 active site 869303003672 catalytic site [active] 869303003673 substrate binding site [chemical binding]; other site 869303003674 Domain of unknown function (DUF955); Region: DUF955; pfam06114 869303003675 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869303003676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303003677 non-specific DNA binding site [nucleotide binding]; other site 869303003678 salt bridge; other site 869303003679 sequence-specific DNA binding site [nucleotide binding]; other site 869303003680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 869303003681 non-specific DNA binding site [nucleotide binding]; other site 869303003682 salt bridge; other site 869303003683 sequence-specific DNA binding site [nucleotide binding]; other site 869303003684 Prophage antirepressor [Transcription]; Region: COG3617 869303003685 BRO family, N-terminal domain; Region: Bro-N; smart01040 869303003686 ORF6C domain; Region: ORF6C; pfam10552 869303003687 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 869303003688 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 869303003689 Raw score 20.25 869303003690 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 869303003691 Raw score 10.23 869303003692 Raw score 3.71 869303003693 Phage-related protein [Function unknown]; Region: COG4695; cl01923 869303003694 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 869303003695 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 869303003696 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 869303003697 Phage capsid family; Region: Phage_capsid; pfam05065 869303003698 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 869303003699 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 869303003700 Raw score 4.87 869303003701 Raw score 5.25 869303003702 Holin family; Region: Phage_holin_4; cl01989 869303003703 Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682 869303003704 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869303003705 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869303003706 amidase catalytic site [active] 869303003707 Zn binding residues [ion binding]; other site 869303003708 substrate binding site [chemical binding]; other site 869303003709 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003710 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 869303003711 nucleoside/Zn binding site; other site 869303003712 dimer interface [polypeptide binding]; other site 869303003713 catalytic motif [active] 869303003714 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 869303003715 trimer interface [polypeptide binding]; other site 869303003716 active site 869303003717 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869303003718 catalytic core [active] 869303003719 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869303003720 DNA repair protein RadA; Provisional; Region: PRK11823 869303003721 Walker A motif; other site 869303003722 ATP binding site [chemical binding]; other site 869303003723 Walker B motif; other site 869303003724 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869303003725 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 869303003726 active site clefts [active] 869303003727 zinc binding site [ion binding]; other site 869303003728 dimer interface [polypeptide binding]; other site 869303003729 Frameshift mutation relative to orthologue in TIGR4; TIGR4 orthologue likely to also be a pseudogene due to an independent frameshift mutation in the upstream region 869303003730 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 869303003731 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869303003732 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303003733 active site 869303003735 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 869303003736 DNA polymerase I; Provisional; Region: PRK05755 869303003737 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869303003738 active site 869303003739 metal binding site 1 [ion binding]; metal-binding site 869303003740 putative 5' ssDNA interaction site; other site 869303003741 metal binding site 3; metal-binding site 869303003742 metal binding site 2 [ion binding]; metal-binding site 869303003743 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869303003744 putative DNA binding site [nucleotide binding]; other site 869303003745 putative metal binding site [ion binding]; other site 869303003746 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 869303003747 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 869303003748 active site 869303003749 DNA binding site [nucleotide binding] 869303003750 catalytic site [active] 869303003751 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 869303003752 Predicted membrane protein [Function unknown]; Region: COG2855 869303003753 aromatic amino acid aminotransferase; Validated; Region: PRK07309 869303003754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869303003755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303003756 homodimer interface [polypeptide binding]; other site 869303003757 catalytic residue [active] 869303003758 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 869303003759 Recombination protein O N terminal; Region: RecO_N; pfam11967 869303003760 Recombination protein O C terminal; Region: RecO_C; pfam02565 869303003761 putative phosphate acyltransferase; Provisional; Region: PRK05331 869303003764 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 869303003765 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 869303003766 putative active site [active] 869303003767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869303003768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303003769 Walker A/P-loop; other site 869303003770 ATP binding site [chemical binding]; other site 869303003771 Q-loop/lid; other site 869303003772 ABC transporter signature motif; other site 869303003773 Walker B; other site 869303003774 D-loop; other site 869303003775 H-loop/switch region; other site 869303003776 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 869303003777 HlyD family secretion protein; Region: HlyD_3; pfam13437 869303003778 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 869303003779 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 869303003780 ATP binding site [chemical binding]; other site 869303003781 active site 869303003782 substrate binding site [chemical binding]; other site 869303003783 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 869303003784 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 869303003785 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 869303003786 dimerization interface [polypeptide binding]; other site 869303003787 ATP binding site [chemical binding]; other site 869303003788 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 869303003789 dimerization interface [polypeptide binding]; other site 869303003790 ATP binding site [chemical binding]; other site 869303003791 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 869303003792 putative active site [active] 869303003793 catalytic triad [active] 869303003794 amidophosphoribosyltransferase; Provisional; Region: PRK07272 869303003795 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 869303003796 active site 869303003797 tetramer interface [polypeptide binding]; other site 869303003798 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303003799 active site 869303003800 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 869303003801 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 869303003802 dimerization interface [polypeptide binding]; other site 869303003803 putative ATP binding site [chemical binding]; other site 869303003804 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 869303003805 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 869303003806 active site 869303003807 substrate binding site [chemical binding]; other site 869303003808 cosubstrate binding site; other site 869303003809 catalytic site [active] 869303003810 VanZ like family; Region: VanZ; pfam04892 869303003811 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 869303003812 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 869303003813 purine monophosphate binding site [chemical binding]; other site 869303003814 dimer interface [polypeptide binding]; other site 869303003815 putative catalytic residues [active] 869303003816 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 869303003817 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 869303003818 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 869303003819 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 869303003820 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 869303003821 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 869303003822 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 869303003823 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 869303003824 ATP-grasp domain; Region: ATP-grasp; pfam02222 869303003825 adenylosuccinate lyase; Provisional; Region: PRK07492 869303003826 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 869303003827 tetramer interface [polypeptide binding]; other site 869303003828 active site 869303003829 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869303003830 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 869303003831 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 869303003832 active site 869303003833 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 869303003834 active site 869303003835 G5 domain; Region: G5; pfam07501 869303003836 G5 domain; Region: G5; pfam07501 869303003837 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869303003838 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869303003839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869303003840 DNA-binding site [nucleotide binding]; DNA binding site 869303003841 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 869303003842 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 869303003843 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 869303003844 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869303003845 active site 869303003846 phosphorylation site [posttranslational modification] 869303003847 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869303003848 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869303003849 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869303003850 active pocket/dimerization site; other site 869303003851 active site 869303003852 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 869303003853 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869303003854 dimer interface [polypeptide binding]; other site 869303003855 active site 869303003856 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 869303003857 putative active site [active] 869303003858 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 869303003859 active site 869303003860 catalytic residues [active] 869303003861 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 869303003862 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 869303003863 putative metal binding site [ion binding]; other site 869303003864 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869303003865 active site 869303003866 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 869303003867 putative homodimer interface [polypeptide binding]; other site 869303003868 putative homotetramer interface [polypeptide binding]; other site 869303003869 putative allosteric switch controlling residues; other site 869303003870 putative metal binding site [ion binding]; other site 869303003871 putative homodimer-homodimer interface [polypeptide binding]; other site 869303003872 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869303003873 active site residue [active] 869303003874 Similar to C-terminus of a protein from other streptococci 869303003876 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869303003877 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869303003878 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 869303003879 TrkA-N domain; Region: TrkA_N; pfam02254 869303003881 Fibronectin-binding repeat; Region: SSURE; pfam11966 869303003882 Fibronectin-binding repeat; Region: SSURE; pfam11966 869303003883 Fibronectin-binding repeat; Region: SSURE; pfam11966 869303003884 Fibronectin-binding repeat; Region: SSURE; pfam11966 869303003885 Fibronectin-binding repeat; Region: SSURE; pfam11966 869303003886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869303003887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303003888 active site 869303003889 phosphorylation site [posttranslational modification] 869303003890 intermolecular recognition site; other site 869303003891 dimerization interface [polypeptide binding]; other site 869303003892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869303003893 DNA binding site [nucleotide binding] 869303003894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869303003895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869303003896 dimerization interface [polypeptide binding]; other site 869303003897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869303003898 dimer interface [polypeptide binding]; other site 869303003899 phosphorylation site [posttranslational modification] 869303003900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303003901 ATP binding site [chemical binding]; other site 869303003902 Mg2+ binding site [ion binding]; other site 869303003903 G-X-G motif; other site 869303003904 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 869303003905 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 869303003906 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869303003907 RNA binding surface [nucleotide binding]; other site 869303003910 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869303003911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303003912 dimer interface [polypeptide binding]; other site 869303003913 conserved gate region; other site 869303003914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869303003915 ABC-ATPase subunit interface; other site 869303003916 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869303003917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303003918 dimer interface [polypeptide binding]; other site 869303003919 conserved gate region; other site 869303003920 putative PBP binding loops; other site 869303003921 ABC-ATPase subunit interface; other site 869303003922 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869303003923 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 869303003924 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 869303003925 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 869303003926 active site residue [active] 869303003927 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 869303003928 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 869303003929 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 869303003930 Predicted membrane protein [Function unknown]; Region: COG4709 869303003931 Predicted transcriptional regulators [Transcription]; Region: COG1695 869303003932 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869303003933 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 869303003934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869303003935 putative substrate translocation pore; other site 869303003936 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 869303003937 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869303003938 Ligand binding site; other site 869303003939 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 869303003940 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869303003941 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 869303003942 NAD(P) binding site [chemical binding]; other site 869303003943 homodimer interface [polypeptide binding]; other site 869303003944 substrate binding site [chemical binding]; other site 869303003945 active site 869303003946 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869303003947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303003948 active site 869303003949 motif I; other site 869303003950 motif II; other site 869303003951 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 869303003952 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 869303003953 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 869303003954 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 869303003955 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 869303003956 putative L-serine binding site [chemical binding]; other site 869303003957 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 869303003958 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869303003959 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 869303003960 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 869303003961 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869303003962 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869303003963 Walker A/P-loop; other site 869303003964 ATP binding site [chemical binding]; other site 869303003965 Q-loop/lid; other site 869303003966 ABC transporter signature motif; other site 869303003967 Walker B; other site 869303003968 D-loop; other site 869303003969 H-loop/switch region; other site 869303003970 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303003971 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869303003972 substrate binding pocket [chemical binding]; other site 869303003973 membrane-bound complex binding site; other site 869303003974 hinge residues; other site 869303003975 argininosuccinate synthase; Provisional; Region: PRK13820 869303003976 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 869303003977 ANP binding site [chemical binding]; other site 869303003978 Substrate Binding Site II [chemical binding]; other site 869303003979 Substrate Binding Site I [chemical binding]; other site 869303003980 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 869303003981 argininosuccinate lyase; Provisional; Region: PRK00855 869303003982 tetramer interface [polypeptide binding]; other site 869303003983 active sites [active] 869303003984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869303003985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303003986 non-specific DNA binding site [nucleotide binding]; other site 869303003987 salt bridge; other site 869303003988 sequence-specific DNA binding site [nucleotide binding]; other site 869303003989 Predicted to be a bacteriocin by BAGEL 869303003990 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 869303003991 Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389 869303003992 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003993 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003994 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003995 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003996 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003997 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869303003998 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869303003999 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 869303004000 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 869303004001 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 869303004002 nudix motif; other site 869303004003 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 869303004004 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 869303004005 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 869303004006 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869303004007 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 869303004008 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869303004009 hypothetical protein; Provisional; Region: PRK13667 869303004010 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 869303004011 Glycoprotease family; Region: Peptidase_M22; pfam00814 869303004012 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 869303004013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303004014 Coenzyme A binding pocket [chemical binding]; other site 869303004015 UGMP family protein; Validated; Region: PRK09604 869303004016 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 869303004017 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 869303004020 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869303004021 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869303004022 active site 869303004023 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869303004024 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 869303004025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869303004026 Walker A/P-loop; other site 869303004027 ATP binding site [chemical binding]; other site 869303004028 Q-loop/lid; other site 869303004029 ABC transporter signature motif; other site 869303004030 Walker B; other site 869303004031 D-loop; other site 869303004032 H-loop/switch region; other site 869303004035 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 869303004036 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 869303004037 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 869303004039 CAAX protease self-immunity; Region: Abi; pfam02517 869303004040 H+ Antiporter protein; Region: 2A0121; TIGR00900 869303004041 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 869303004042 Predicted membrane protein [Function unknown]; Region: COG4392 869303004043 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869303004044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303004045 substrate binding pocket [chemical binding]; other site 869303004046 membrane-bound complex binding site; other site 869303004047 hinge residues; other site 869303004048 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 869303004049 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 869303004050 hypothetical protein; Provisional; Region: PRK06446 869303004051 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 869303004052 metal binding site [ion binding]; metal-binding site 869303004053 dimer interface [polypeptide binding]; other site 869303004054 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 869303004055 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 869303004056 Walker A/P-loop; other site 869303004057 ATP binding site [chemical binding]; other site 869303004058 Q-loop/lid; other site 869303004059 ABC transporter signature motif; other site 869303004060 Walker B; other site 869303004061 D-loop; other site 869303004062 H-loop/switch region; other site 869303004063 NIL domain; Region: NIL; pfam09383 869303004064 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 869303004065 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 869303004066 Predicted integral membrane protein [Function unknown]; Region: COG5578 869303004067 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869303004068 HAMP domain; Region: HAMP; pfam00672 869303004069 Histidine kinase; Region: His_kinase; pfam06580 869303004070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303004071 ATP binding site [chemical binding]; other site 869303004072 Mg2+ binding site [ion binding]; other site 869303004073 G-X-G motif; other site 869303004074 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 869303004075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303004076 active site 869303004077 phosphorylation site [posttranslational modification] 869303004078 intermolecular recognition site; other site 869303004079 dimerization interface [polypeptide binding]; other site 869303004080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869303004081 flavoprotein NrdI; Provisional; Region: PRK02551 869303004082 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 869303004083 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 869303004084 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869303004085 LytTr DNA-binding domain; Region: LytTR; smart00850 869303004086 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 869303004087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303004088 ATP binding site [chemical binding]; other site 869303004089 Mg2+ binding site [ion binding]; other site 869303004090 G-X-G motif; other site 869303004091 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 869303004092 ATP binding site [chemical binding]; other site 869303004093 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 869303004094 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 869303004095 homopentamer interface [polypeptide binding]; other site 869303004096 active site 869303004097 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 869303004098 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 869303004099 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 869303004100 dimerization interface [polypeptide binding]; other site 869303004101 active site 869303004102 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 869303004103 Lumazine binding domain; Region: Lum_binding; pfam00677 869303004104 Lumazine binding domain; Region: Lum_binding; pfam00677 869303004105 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 869303004106 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 869303004107 catalytic motif [active] 869303004108 Zn binding site [ion binding]; other site 869303004109 RibD C-terminal domain; Region: RibD_C; cl17279 869303004110 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 869303004111 RuvA N terminal domain; Region: RuvA_N; pfam01330 869303004112 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 869303004113 CAAX protease self-immunity; Region: Abi; pfam02517 869303004114 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 869303004115 putative dimer interface [polypeptide binding]; other site 869303004116 catalytic triad [active] 869303004117 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 869303004118 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869303004119 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 869303004120 Cl binding site [ion binding]; other site 869303004121 oligomer interface [polypeptide binding]; other site 869303004122 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 869303004123 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869303004124 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869303004125 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 869303004126 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869303004127 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869303004128 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869303004129 active site 869303004130 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 869303004131 Helix-turn-helix domain; Region: HTH_38; pfam13936 869303004132 Integrase core domain; Region: rve; pfam00665 869303004133 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 869303004134 ArsC family; Region: ArsC; pfam03960 869303004135 putative catalytic residues [active] 869303004136 thiol/disulfide switch; other site 869303004137 hypothetical protein; Provisional; Region: PRK05473 869303004138 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 869303004139 hypothetical protein; Provisional; Region: PRK13678 869303004140 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 869303004141 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869303004142 Bacterial lipoprotein; Region: DUF3642; pfam12182 869303004143 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 869303004144 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 869303004145 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 869303004146 putative active site [active] 869303004147 catalytic site [active] 869303004148 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 869303004149 putative active site [active] 869303004150 catalytic site [active] 869303004151 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 869303004152 ATP cone domain; Region: ATP-cone; pfam03477 869303004153 Class III ribonucleotide reductase; Region: RNR_III; cd01675 869303004154 effector binding site; other site 869303004155 active site 869303004156 Zn binding site [ion binding]; other site 869303004157 glycine loop; other site 869303004158 Predicted acetyltransferase [General function prediction only]; Region: COG3981 869303004159 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869303004160 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 869303004161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869303004162 FeS/SAM binding site; other site 869303004163 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869303004164 active site 869303004165 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 869303004166 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 869303004167 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 869303004168 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 869303004169 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 869303004170 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 869303004171 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 869303004172 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 869303004173 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 869303004174 putative translocon binding site; other site 869303004175 protein-rRNA interface [nucleotide binding]; other site 869303004176 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 869303004177 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 869303004178 G-X-X-G motif; other site 869303004179 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 869303004180 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 869303004181 23S rRNA interface [nucleotide binding]; other site 869303004182 5S rRNA interface [nucleotide binding]; other site 869303004183 putative antibiotic binding site [chemical binding]; other site 869303004184 L25 interface [polypeptide binding]; other site 869303004185 L27 interface [polypeptide binding]; other site 869303004186 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 869303004187 23S rRNA interface [nucleotide binding]; other site 869303004188 putative translocon interaction site; other site 869303004189 signal recognition particle (SRP54) interaction site; other site 869303004190 L23 interface [polypeptide binding]; other site 869303004191 trigger factor interaction site; other site 869303004192 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 869303004193 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 869303004194 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 869303004195 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 869303004196 RNA binding site [nucleotide binding]; other site 869303004197 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 869303004198 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 869303004199 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 869303004200 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 869303004201 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 869303004202 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 869303004203 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869303004204 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869303004205 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 869303004206 5S rRNA interface [nucleotide binding]; other site 869303004207 L27 interface [polypeptide binding]; other site 869303004208 23S rRNA interface [nucleotide binding]; other site 869303004209 L5 interface [polypeptide binding]; other site 869303004210 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 869303004211 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 869303004212 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 869303004213 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 869303004214 23S rRNA binding site [nucleotide binding]; other site 869303004215 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 869303004216 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 869303004217 SecY translocase; Region: SecY; pfam00344 869303004218 adenylate kinase; Reviewed; Region: adk; PRK00279 869303004219 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 869303004220 AMP-binding site [chemical binding]; other site 869303004221 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 869303004222 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 869303004223 rRNA binding site [nucleotide binding]; other site 869303004224 predicted 30S ribosome binding site; other site 869303004225 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 869303004226 30S ribosomal protein S13; Region: bact_S13; TIGR03631 869303004227 30S ribosomal protein S11; Validated; Region: PRK05309 869303004228 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 869303004229 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 869303004230 alphaNTD homodimer interface [polypeptide binding]; other site 869303004231 alphaNTD - beta interaction site [polypeptide binding]; other site 869303004232 alphaNTD - beta' interaction site [polypeptide binding]; other site 869303004233 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 869303004234 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 869303004235 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 869303004236 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 869303004237 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869303004238 catalytic core [active] 869303004239 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869303004240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303004241 dimer interface [polypeptide binding]; other site 869303004242 conserved gate region; other site 869303004243 putative PBP binding loops; other site 869303004244 ABC-ATPase subunit interface; other site 869303004245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869303004246 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869303004247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303004248 Walker A/P-loop; other site 869303004249 ATP binding site [chemical binding]; other site 869303004250 Q-loop/lid; other site 869303004251 ABC transporter signature motif; other site 869303004252 Walker B; other site 869303004253 D-loop; other site 869303004254 H-loop/switch region; other site 869303004255 TOBE domain; Region: TOBE_2; pfam08402 869303004256 CDS apparently disrupted by a RUP element insertion 869303004257 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869303004258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869303004259 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 869303004260 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869303004261 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869303004262 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869303004263 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 869303004264 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 869303004265 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869303004266 active site 869303004267 methionine cluster; other site 869303004268 phosphorylation site [posttranslational modification] 869303004269 metal binding site [ion binding]; metal-binding site 869303004270 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869303004271 active site 869303004272 P-loop; other site 869303004273 phosphorylation site [posttranslational modification] 869303004274 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869303004275 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869303004276 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 869303004277 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 869303004278 dimer interface [polypeptide binding]; other site 869303004279 active site 869303004280 glycine loop; other site 869303004281 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 869303004282 active site 869303004283 intersubunit interactions; other site 869303004284 catalytic residue [active] 869303004285 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869303004286 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 869303004287 dimer interface [polypeptide binding]; other site 869303004288 active site 869303004289 metal binding site [ion binding]; metal-binding site 869303004290 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 869303004291 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869303004292 HIGH motif; other site 869303004293 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869303004294 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869303004295 active site 869303004296 KMSKS motif; other site 869303004297 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 869303004298 tRNA binding surface [nucleotide binding]; other site 869303004299 GNAT acetyltransferase gene disrupted by a RUP insertion and a frameshift mutation 869303004300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 869303004301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303004302 Coenzyme A binding pocket [chemical binding]; other site 869303004303 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 869303004304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303004305 Walker A motif; other site 869303004306 ATP binding site [chemical binding]; other site 869303004307 Walker B motif; other site 869303004308 arginine finger; other site 869303004309 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 869303004311 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 869303004312 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 869303004313 catalytic residue [active] 869303004314 putative FPP diphosphate binding site; other site 869303004315 putative FPP binding hydrophobic cleft; other site 869303004316 dimer interface [polypeptide binding]; other site 869303004317 putative IPP diphosphate binding site; other site 869303004318 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 869303004319 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 869303004320 RIP metalloprotease RseP; Region: TIGR00054 869303004321 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869303004322 active site 869303004323 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 869303004324 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869303004325 putative substrate binding region [chemical binding]; other site 869303004326 prolyl-tRNA synthetase; Provisional; Region: PRK09194 869303004327 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 869303004328 dimer interface [polypeptide binding]; other site 869303004329 motif 1; other site 869303004330 active site 869303004331 motif 2; other site 869303004332 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 869303004333 putative deacylase active site [active] 869303004334 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869303004335 active site 869303004336 motif 3; other site 869303004337 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 869303004338 anticodon binding site; other site 869303004339 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869303004340 beta-galactosidase; Region: BGL; TIGR03356 869303004341 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 869303004342 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 869303004343 glutaminase active site [active] 869303004344 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869303004345 dimer interface [polypeptide binding]; other site 869303004346 active site 869303004347 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 869303004348 dimer interface [polypeptide binding]; other site 869303004349 active site 869303004350 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 869303004351 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 869303004353 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 869303004354 S17 interaction site [polypeptide binding]; other site 869303004355 S8 interaction site; other site 869303004356 16S rRNA interaction site [nucleotide binding]; other site 869303004357 streptomycin interaction site [chemical binding]; other site 869303004358 23S rRNA interaction site [nucleotide binding]; other site 869303004359 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 869303004360 30S ribosomal protein S7; Validated; Region: PRK05302 869303004361 elongation factor G; Reviewed; Region: PRK00007 869303004362 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 869303004363 G1 box; other site 869303004364 putative GEF interaction site [polypeptide binding]; other site 869303004365 GTP/Mg2+ binding site [chemical binding]; other site 869303004366 Switch I region; other site 869303004367 G2 box; other site 869303004368 G3 box; other site 869303004369 Switch II region; other site 869303004370 G4 box; other site 869303004371 G5 box; other site 869303004372 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 869303004373 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 869303004374 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 869303004375 DNA polymerase III PolC; Validated; Region: polC; PRK00448 869303004376 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 869303004377 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 869303004378 generic binding surface II; other site 869303004379 generic binding surface I; other site 869303004380 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 869303004381 active site 869303004382 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869303004383 active site 869303004384 catalytic site [active] 869303004385 substrate binding site [chemical binding]; other site 869303004386 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 869303004387 putative PHP Thumb interface [polypeptide binding]; other site 869303004388 active site 869303004389 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 869303004390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 869303004391 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 869303004392 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 869303004393 Predicted membrane protein [Function unknown]; Region: COG2261 869303004394 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869303004395 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869303004396 RNA binding surface [nucleotide binding]; other site 869303004397 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869303004398 active site 869303004399 uracil binding [chemical binding]; other site 869303004400 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 869303004401 trimer interface [polypeptide binding]; other site 869303004402 active site 869303004403 G bulge; other site 869303004404 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869303004405 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 869303004406 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 869303004407 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869303004408 active pocket/dimerization site; other site 869303004409 active site 869303004410 phosphorylation site [posttranslational modification] 869303004411 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869303004412 active site 869303004413 phosphorylation site [posttranslational modification] 869303004414 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 869303004415 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 869303004416 NAD binding site [chemical binding]; other site 869303004417 substrate binding site [chemical binding]; other site 869303004418 catalytic Zn binding site [ion binding]; other site 869303004419 tetramer interface [polypeptide binding]; other site 869303004420 structural Zn binding site [ion binding]; other site 869303004421 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869303004422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303004423 active site 869303004424 motif I; other site 869303004425 motif II; other site 869303004426 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869303004427 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 869303004428 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 869303004429 dihydropteroate synthase; Region: DHPS; TIGR01496 869303004430 substrate binding pocket [chemical binding]; other site 869303004431 dimer interface [polypeptide binding]; other site 869303004432 inhibitor binding site; inhibition site 869303004433 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 869303004434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869303004435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869303004436 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 869303004437 homodecamer interface [polypeptide binding]; other site 869303004438 GTP cyclohydrolase I; Provisional; Region: PLN03044 869303004439 active site 869303004440 putative catalytic site residues [active] 869303004441 zinc binding site [ion binding]; other site 869303004442 GTP-CH-I/GFRP interaction surface; other site 869303004443 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 869303004444 homooctamer interface [polypeptide binding]; other site 869303004445 active site 869303004446 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 869303004447 catalytic center binding site [active] 869303004448 ATP binding site [chemical binding]; other site 869303004449 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 869303004450 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 869303004451 23S rRNA interface [nucleotide binding]; other site 869303004452 L3 interface [polypeptide binding]; other site 869303004453 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 869303004454 Uncharacterized conserved protein [Function unknown]; Region: COG1359 869303004455 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 869303004456 beta-galactosidase; Region: BGL; TIGR03356 869303004457 Uncharacterized conserved protein [Function unknown]; Region: COG4095 869303004458 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 869303004459 active site 869303004460 P-loop; other site 869303004461 phosphorylation site [posttranslational modification] 869303004462 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869303004463 HTH domain; Region: HTH_11; pfam08279 869303004464 Mga helix-turn-helix domain; Region: Mga; pfam05043 869303004465 PRD domain; Region: PRD; pfam00874 869303004466 PRD domain; Region: PRD; pfam00874 869303004467 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869303004468 active site 869303004469 P-loop; other site 869303004470 phosphorylation site [posttranslational modification] 869303004471 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 869303004472 active site 869303004473 phosphorylation site [posttranslational modification] 869303004474 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869303004475 methionine cluster; other site 869303004476 active site 869303004477 phosphorylation site [posttranslational modification] 869303004478 metal binding site [ion binding]; metal-binding site 869303004479 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869303004480 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869303004483 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 869303004484 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 869303004485 putative active site [active] 869303004486 putative catalytic site [active] 869303004487 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 869303004488 catalytic residues [active] 869303004489 dimer interface [polypeptide binding]; other site 869303004492 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 869303004493 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 869303004494 active site 869303004495 intersubunit interface [polypeptide binding]; other site 869303004496 catalytic residue [active] 869303004497 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869303004498 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 869303004499 substrate binding site [chemical binding]; other site 869303004500 ATP binding site [chemical binding]; other site 869303004501 hypothetical protein; Provisional; Region: PRK09273 869303004502 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 869303004503 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 869303004504 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 869303004505 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 869303004506 NADP binding site [chemical binding]; other site 869303004507 homodimer interface [polypeptide binding]; other site 869303004508 active site 869303004509 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869303004510 active pocket/dimerization site; other site 869303004511 active site 869303004512 phosphorylation site [posttranslational modification] 869303004513 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 869303004514 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869303004515 active site 869303004516 phosphorylation site [posttranslational modification] 869303004517 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869303004518 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869303004519 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 869303004520 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 869303004521 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869303004522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869303004523 DNA binding site [nucleotide binding] 869303004524 domain linker motif; other site 869303004525 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 869303004526 putative dimerization interface [polypeptide binding]; other site 869303004527 putative ligand binding site [chemical binding]; other site 869303004528 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 869303004529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303004530 non-specific DNA binding site [nucleotide binding]; other site 869303004531 salt bridge; other site 869303004532 sequence-specific DNA binding site [nucleotide binding]; other site 869303004533 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 869303004534 MraW methylase family; Region: Methyltransf_5; pfam01795 869303004535 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 869303004536 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869303004537 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869303004538 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869303004539 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 869303004540 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 869303004541 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 869303004542 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 869303004543 Mg++ binding site [ion binding]; other site 869303004544 putative catalytic motif [active] 869303004545 putative substrate binding site [chemical binding]; other site 869303004546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303004547 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869303004548 Walker A motif; other site 869303004549 ATP binding site [chemical binding]; other site 869303004550 Walker B motif; other site 869303004551 arginine finger; other site 869303004552 UvrB/uvrC motif; Region: UVR; pfam02151 869303004553 MoxR-like ATPases [General function prediction only]; Region: COG0714 869303004554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303004555 Walker A motif; other site 869303004556 ATP binding site [chemical binding]; other site 869303004557 Walker B motif; other site 869303004558 arginine finger; other site 869303004559 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869303004560 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 869303004561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 869303004562 hypothetical protein; Provisional; Region: PRK13663 869303004563 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869303004564 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869303004565 Ca binding site [ion binding]; other site 869303004566 active site 869303004567 catalytic site [active] 869303004572 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 869303004573 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 869303004575 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 869303004576 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869303004577 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 869303004578 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 869303004579 Hyaluronan synthases catalyze polymerization of hyaluronan; Region: GT2_HAS; cd06434 869303004580 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869303004581 DXD motif; other site 869303004582 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869303004583 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869303004584 active site 869303004585 tetramer interface; other site 869303004586 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 869303004587 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 869303004588 active site 869303004589 substrate binding site [chemical binding]; other site 869303004590 metal binding site [ion binding]; metal-binding site 869303004591 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869303004592 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869303004593 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 869303004594 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869303004595 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 869303004596 Transglycosylase; Region: Transgly; pfam00912 869303004597 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 869303004598 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869303004599 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 869303004600 hypothetical protein; Provisional; Region: PRK13660 869303004601 cell division protein GpsB; Provisional; Region: PRK14127 869303004602 DivIVA domain; Region: DivI1A_domain; TIGR03544 869303004603 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 869303004604 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 869303004605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869303004606 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869303004607 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 869303004608 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 869303004609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869303004610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303004611 active site 869303004612 phosphorylation site [posttranslational modification] 869303004613 intermolecular recognition site; other site 869303004614 dimerization interface [polypeptide binding]; other site 869303004615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869303004616 DNA binding site [nucleotide binding] 869303004617 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869303004618 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869303004619 Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403 869303004620 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 869303004621 active site 869303004622 zinc binding site [ion binding]; other site 869303004623 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 869303004624 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 869303004625 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869303004626 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869303004627 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 869303004628 diphosphomevalonate decarboxylase; Region: PLN02407 869303004629 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 869303004630 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869303004631 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 869303004632 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 869303004633 homotetramer interface [polypeptide binding]; other site 869303004634 FMN binding site [chemical binding]; other site 869303004635 homodimer contacts [polypeptide binding]; other site 869303004636 putative active site [active] 869303004637 putative substrate binding site [chemical binding]; other site 869303004638 Predicted membrane protein [Function unknown]; Region: COG4758 869303004639 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 869303004640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869303004641 Histidine kinase; Region: HisKA_3; pfam07730 869303004642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303004643 ATP binding site [chemical binding]; other site 869303004644 Mg2+ binding site [ion binding]; other site 869303004645 G-X-G motif; other site 869303004646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869303004647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303004648 active site 869303004649 phosphorylation site [posttranslational modification] 869303004650 intermolecular recognition site; other site 869303004651 dimerization interface [polypeptide binding]; other site 869303004652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869303004653 DNA binding residues [nucleotide binding] 869303004654 dimerization interface [polypeptide binding]; other site 869303004655 Appears to have been disrupted through the insertion of a BOX element; Gene model based on TIGR4 annotation and Fasta sequence similarity 869303004656 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869303004657 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869303004658 DNA binding site [nucleotide binding] 869303004659 Int/Topo IB signature motif; other site 869303004660 active site 869303004661 trigger factor; Provisional; Region: tig; PRK01490 869303004662 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869303004663 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 869303004664 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 869303004665 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 869303004666 DNA binding site [nucleotide binding] 869303004667 AAA domain; Region: AAA_30; pfam13604 869303004668 Family description; Region: UvrD_C_2; pfam13538 869303004669 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 869303004670 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 869303004671 Catalytic site [active] 869303004672 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869303004673 ribonuclease HIII; Provisional; Region: PRK00996 869303004674 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 869303004675 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 869303004676 RNA/DNA hybrid binding site [nucleotide binding]; other site 869303004677 active site 869303004678 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 869303004679 Colicin V production protein; Region: Colicin_V; pfam02674 869303004680 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 869303004681 MutS domain III; Region: MutS_III; pfam05192 869303004682 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 869303004683 Walker A/P-loop; other site 869303004684 ATP binding site [chemical binding]; other site 869303004685 Q-loop/lid; other site 869303004686 ABC transporter signature motif; other site 869303004687 Walker B; other site 869303004688 D-loop; other site 869303004689 H-loop/switch region; other site 869303004690 Smr domain; Region: Smr; pfam01713 869303004691 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 869303004692 amino acid carrier protein; Region: agcS; TIGR00835 869303004693 Uncharacterized conserved protein [Function unknown]; Region: COG2128 869303004694 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 869303004695 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 869303004696 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 869303004697 gating phenylalanine in ion channel; other site 869303004699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 869303004700 aspartate kinase; Reviewed; Region: PRK09034 869303004701 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 869303004702 putative catalytic residues [active] 869303004703 putative nucleotide binding site [chemical binding]; other site 869303004704 putative aspartate binding site [chemical binding]; other site 869303004705 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 869303004706 allosteric regulatory residue; other site 869303004707 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 869303004708 enoyl-CoA hydratase; Provisional; Region: PRK07260 869303004709 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869303004710 substrate binding site [chemical binding]; other site 869303004711 oxyanion hole (OAH) forming residues; other site 869303004712 trimer interface [polypeptide binding]; other site 869303004713 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869303004714 MarR family; Region: MarR_2; pfam12802 869303004715 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 869303004716 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 869303004717 dimer interface [polypeptide binding]; other site 869303004718 active site 869303004719 CoA binding pocket [chemical binding]; other site 869303004720 acyl carrier protein; Provisional; Region: acpP; PRK00982 869303004721 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 869303004722 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 869303004723 FMN binding site [chemical binding]; other site 869303004724 substrate binding site [chemical binding]; other site 869303004725 putative catalytic residue [active] 869303004726 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 869303004727 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869303004728 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 869303004729 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 869303004730 NAD(P) binding site [chemical binding]; other site 869303004731 homotetramer interface [polypeptide binding]; other site 869303004732 homodimer interface [polypeptide binding]; other site 869303004733 active site 869303004734 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 869303004735 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 869303004736 dimer interface [polypeptide binding]; other site 869303004737 active site 869303004738 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 869303004739 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869303004740 carboxyltransferase (CT) interaction site; other site 869303004741 biotinylation site [posttranslational modification]; other site 869303004742 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 869303004743 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 869303004744 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869303004745 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869303004746 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 869303004747 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 869303004748 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 869303004749 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 869303004750 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 869303004752 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 869303004753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869303004754 elongation factor P; Validated; Region: PRK00529 869303004755 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 869303004756 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 869303004757 RNA binding site [nucleotide binding]; other site 869303004758 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 869303004759 RNA binding site [nucleotide binding]; other site 869303004760 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 869303004761 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 869303004762 GatB domain; Region: GatB_Yqey; pfam02637 869303004763 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 869303004764 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 869303004765 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 869303004766 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 869303004767 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 869303004768 G1 box; other site 869303004769 putative GEF interaction site [polypeptide binding]; other site 869303004770 GTP/Mg2+ binding site [chemical binding]; other site 869303004771 Switch I region; other site 869303004772 G2 box; other site 869303004773 G3 box; other site 869303004774 Switch II region; other site 869303004775 G4 box; other site 869303004776 G5 box; other site 869303004777 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 869303004778 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 869303004779 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 869303004780 Ligand binding site; other site 869303004781 metal-binding site 869303004782 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 869303004783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869303004784 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 869303004785 DAK2 domain; Region: Dak2; pfam02734 869303004786 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 869303004787 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869303004788 PYR/PP interface [polypeptide binding]; other site 869303004789 dimer interface [polypeptide binding]; other site 869303004790 TPP binding site [chemical binding]; other site 869303004791 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869303004792 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 869303004793 TPP-binding site [chemical binding]; other site 869303004794 dimer interface [polypeptide binding]; other site 869303004795 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 869303004796 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 869303004797 putative valine binding site [chemical binding]; other site 869303004798 dimer interface [polypeptide binding]; other site 869303004799 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 869303004800 ketol-acid reductoisomerase; Provisional; Region: PRK05479 869303004801 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 869303004802 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869303004804 threonine dehydratase; Validated; Region: PRK08639 869303004805 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 869303004806 tetramer interface [polypeptide binding]; other site 869303004807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303004808 catalytic residue [active] 869303004809 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 869303004810 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869303004811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303004812 Walker A/P-loop; other site 869303004813 ATP binding site [chemical binding]; other site 869303004814 Q-loop/lid; other site 869303004815 ABC transporter signature motif; other site 869303004816 Walker B; other site 869303004817 D-loop; other site 869303004818 H-loop/switch region; other site 869303004819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303004820 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869303004821 substrate binding pocket [chemical binding]; other site 869303004822 membrane-bound complex binding site; other site 869303004823 hinge residues; other site 869303004824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303004825 dimer interface [polypeptide binding]; other site 869303004826 conserved gate region; other site 869303004827 putative PBP binding loops; other site 869303004828 ABC-ATPase subunit interface; other site 869303004829 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 869303004831 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 869303004832 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 869303004833 active site 869303004834 DNA polymerase IV; Validated; Region: PRK02406 869303004835 DNA binding site [nucleotide binding] 869303004836 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 869303004837 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 869303004839 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869303004840 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 869303004841 non-specific DNA interactions [nucleotide binding]; other site 869303004842 DNA binding site [nucleotide binding] 869303004843 sequence specific DNA binding site [nucleotide binding]; other site 869303004844 putative cAMP binding site [chemical binding]; other site 869303004845 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869303004846 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869303004847 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869303004848 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869303004849 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869303004850 methionine cluster; other site 869303004851 active site 869303004852 phosphorylation site [posttranslational modification] 869303004853 metal binding site [ion binding]; metal-binding site 869303004854 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 869303004855 beta-galactosidase; Region: BGL; TIGR03356 869303004856 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869303004857 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869303004858 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 869303004859 active site 869303004860 P-loop; other site 869303004861 phosphorylation site [posttranslational modification] 869303004862 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869303004863 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869303004864 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 869303004865 TrkA-N domain; Region: TrkA_N; pfam02254 869303004866 TrkA-C domain; Region: TrkA_C; pfam02080 869303004867 TrkA-N domain; Region: TrkA_N; pfam02254 869303004868 TrkA-C domain; Region: TrkA_C; pfam02080 869303004869 Uncharacterized conserved protein [Function unknown]; Region: COG1912 869303004870 hypothetical protein; Provisional; Region: PRK13661 869303004871 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869303004872 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869303004873 Walker A/P-loop; other site 869303004874 ATP binding site [chemical binding]; other site 869303004875 Q-loop/lid; other site 869303004876 ABC transporter signature motif; other site 869303004877 Walker B; other site 869303004878 D-loop; other site 869303004879 H-loop/switch region; other site 869303004880 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 869303004881 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869303004882 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869303004883 Walker A/P-loop; other site 869303004884 ATP binding site [chemical binding]; other site 869303004885 Q-loop/lid; other site 869303004886 ABC transporter signature motif; other site 869303004887 Walker B; other site 869303004888 D-loop; other site 869303004889 H-loop/switch region; other site 869303004890 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869303004891 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 869303004892 Predicted membrane protein [Function unknown]; Region: COG3601 869303004893 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 869303004894 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869303004895 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 869303004896 active site 869303004898 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869303004899 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869303004900 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 869303004901 CTP synthetase; Validated; Region: pyrG; PRK05380 869303004902 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 869303004903 Catalytic site [active] 869303004904 active site 869303004905 UTP binding site [chemical binding]; other site 869303004906 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 869303004907 active site 869303004908 putative oxyanion hole; other site 869303004909 catalytic triad [active] 869303004910 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 869303004911 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869303004912 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869303004913 PhoU domain; Region: PhoU; pfam01895 869303004914 PhoU domain; Region: PhoU; pfam01895 869303004915 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869303004916 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 869303004917 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 869303004918 putative active site [active] 869303004919 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869303004920 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 869303004921 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 869303004922 G5 domain; Region: G5; pfam07501 869303004923 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 869303004924 Phosphoglycerate kinase; Region: PGK; pfam00162 869303004925 substrate binding site [chemical binding]; other site 869303004926 hinge regions; other site 869303004927 ADP binding site [chemical binding]; other site 869303004928 catalytic site [active] 869303004929 Predicted membrane protein [Function unknown]; Region: COG4129 869303004930 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869303004931 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 869303004932 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 869303004933 DNA binding residues [nucleotide binding] 869303004934 putative dimer interface [polypeptide binding]; other site 869303004935 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 869303004936 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 869303004937 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 869303004938 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869303004939 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869303004940 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869303004941 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 869303004942 VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196 869303004943 Int/Topo IB signature motif; other site 869303004944 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869303004945 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869303004946 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869303004947 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869303004948 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869303004949 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869303004950 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869303004951 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 869303004952 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 869303004953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869303004954 ATP binding site [chemical binding]; other site 869303004955 putative Mg++ binding site [ion binding]; other site 869303004956 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 869303004957 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 869303004958 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 869303004959 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 869303004960 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 869303004961 dimer interface [polypeptide binding]; other site 869303004962 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 869303004963 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 869303004964 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 869303004965 nucleotide binding site [chemical binding]; other site 869303004966 NEF interaction site [polypeptide binding]; other site 869303004967 SBD interface [polypeptide binding]; other site 869303004969 chaperone protein DnaJ; Provisional; Region: PRK14276 869303004970 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869303004971 HSP70 interaction site [polypeptide binding]; other site 869303004972 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 869303004973 substrate binding site [polypeptide binding]; other site 869303004974 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 869303004975 Zn binding sites [ion binding]; other site 869303004976 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869303004977 substrate binding site [polypeptide binding]; other site 869303004978 dimer interface [polypeptide binding]; other site 869303004979 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 869303004980 HIT family signature motif; other site 869303004981 catalytic residue [active] 869303004982 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869303004983 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869303004984 Walker A/P-loop; other site 869303004985 ATP binding site [chemical binding]; other site 869303004986 Q-loop/lid; other site 869303004987 ABC transporter signature motif; other site 869303004988 Walker B; other site 869303004989 D-loop; other site 869303004990 H-loop/switch region; other site 869303004991 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 869303004992 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869303004993 LytTr DNA-binding domain; Region: LytTR; pfam04397 869303004994 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869303004995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303004996 active site 869303004997 phosphorylation site [posttranslational modification] 869303004998 intermolecular recognition site; other site 869303004999 dimerization interface [polypeptide binding]; other site 869303005000 LytTr DNA-binding domain; Region: LytTR; pfam04397 869303005001 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869303005002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303005003 ATP binding site [chemical binding]; other site 869303005004 Mg2+ binding site [ion binding]; other site 869303005005 G-X-G motif; other site 869303005006 COMC family; Region: ComC; pfam03047 869303005007 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 869303005008 HlyD family secretion protein; Region: HlyD_3; pfam13437 869303005010 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 869303005011 putative active site [active] 869303005012 CAAX protease self-immunity; Region: Abi; pfam02517 869303005013 disrupted by a BOX element insertion 869303005014 CAAX protease self-immunity; Region: Abi; pfam02517 869303005015 Phosphotransferase enzyme family; Region: APH; pfam01636 869303005016 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 869303005017 substrate binding site [chemical binding]; other site 869303005018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303005019 S-adenosylmethionine binding site [chemical binding]; other site 869303005020 ribosome maturation protein RimP; Reviewed; Region: PRK00092 869303005021 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 869303005022 putative oligomer interface [polypeptide binding]; other site 869303005023 putative RNA binding site [nucleotide binding]; other site 869303005024 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 869303005025 NusA N-terminal domain; Region: NusA_N; pfam08529 869303005026 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 869303005027 RNA binding site [nucleotide binding]; other site 869303005028 homodimer interface [polypeptide binding]; other site 869303005029 NusA-like KH domain; Region: KH_5; pfam13184 869303005030 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 869303005031 G-X-X-G motif; other site 869303005032 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 869303005033 putative RNA binding cleft [nucleotide binding]; other site 869303005034 hypothetical protein; Provisional; Region: PRK07283 869303005035 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869303005036 translation initiation factor IF-2; Region: IF-2; TIGR00487 869303005037 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869303005038 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 869303005039 G1 box; other site 869303005040 putative GEF interaction site [polypeptide binding]; other site 869303005041 GTP/Mg2+ binding site [chemical binding]; other site 869303005042 Switch I region; other site 869303005043 G2 box; other site 869303005044 G3 box; other site 869303005045 Switch II region; other site 869303005046 G4 box; other site 869303005047 G5 box; other site 869303005048 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 869303005049 Translation-initiation factor 2; Region: IF-2; pfam11987 869303005050 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 869303005051 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 869303005052 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 869303005053 Uncharacterized conserved protein [Function unknown]; Region: COG2461 869303005054 Family of unknown function (DUF438); Region: DUF438; pfam04282 869303005055 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 869303005056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 869303005057 putative active site [active] 869303005058 heme pocket [chemical binding]; other site 869303005059 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 869303005060 hypothetical protein; Provisional; Region: PRK07758 869303005061 Flavin Reductases; Region: FlaRed; cl00801 869303005062 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869303005063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869303005064 AAA domain; Region: AAA_18; pfam13238 869303005065 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 869303005066 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869303005067 active site 869303005068 HIGH motif; other site 869303005069 nucleotide binding site [chemical binding]; other site 869303005070 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869303005071 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 869303005072 active site 869303005073 KMSKS motif; other site 869303005074 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 869303005075 tRNA binding surface [nucleotide binding]; other site 869303005076 anticodon binding site; other site 869303005077 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 869303005078 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 869303005079 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 869303005080 Fic/DOC family; Region: Fic; pfam02661 869303005083 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 869303005084 putative active site [active] 869303005085 catalytic site [active] 869303005086 transcriptional antiterminator BglG; Provisional; Region: PRK09772 869303005087 CAT RNA binding domain; Region: CAT_RBD; smart01061 869303005088 PRD domain; Region: PRD; pfam00874 869303005089 PRD domain; Region: PRD; pfam00874 869303005090 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 869303005091 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869303005092 active site turn [active] 869303005093 phosphorylation site [posttranslational modification] 869303005094 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869303005095 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869303005096 HPr interaction site; other site 869303005097 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869303005098 active site 869303005099 phosphorylation site [posttranslational modification] 869303005100 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869303005101 beta-galactosidase; Region: BGL; TIGR03356 869303005102 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 869303005103 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 869303005104 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 869303005105 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 869303005106 dimer interface [polypeptide binding]; other site 869303005107 motif 1; other site 869303005108 active site 869303005109 motif 2; other site 869303005110 motif 3; other site 869303005111 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869303005112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303005113 Coenzyme A binding pocket [chemical binding]; other site 869303005114 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 869303005115 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869303005116 putative tRNA-binding site [nucleotide binding]; other site 869303005117 B3/4 domain; Region: B3_4; pfam03483 869303005118 tRNA synthetase B5 domain; Region: B5; smart00874 869303005119 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 869303005120 dimer interface [polypeptide binding]; other site 869303005121 motif 1; other site 869303005122 motif 3; other site 869303005123 motif 2; other site 869303005124 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 869303005125 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 869303005126 putative catalytic site [active] 869303005127 putative metal binding site [ion binding]; other site 869303005128 putative phosphate binding site [ion binding]; other site 869303005130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869303005131 non-specific DNA binding site [nucleotide binding]; other site 869303005132 salt bridge; other site 869303005133 sequence-specific DNA binding site [nucleotide binding]; other site 869303005134 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 869303005135 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 869303005136 THF binding site; other site 869303005137 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 869303005138 substrate binding site [chemical binding]; other site 869303005139 THF binding site; other site 869303005140 zinc-binding site [ion binding]; other site 869303005141 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 869303005142 FAD binding site [chemical binding]; other site 869303005143 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 869303005144 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 869303005145 RNase E interface [polypeptide binding]; other site 869303005146 trimer interface [polypeptide binding]; other site 869303005147 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 869303005148 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 869303005149 RNase E interface [polypeptide binding]; other site 869303005150 trimer interface [polypeptide binding]; other site 869303005151 active site 869303005152 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 869303005153 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 869303005154 RNA binding site [nucleotide binding]; other site 869303005155 domain interface; other site 869303005156 serine O-acetyltransferase; Region: cysE; TIGR01172 869303005157 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 869303005158 trimer interface [polypeptide binding]; other site 869303005159 active site 869303005160 substrate binding site [chemical binding]; other site 869303005161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303005162 Coenzyme A binding pocket [chemical binding]; other site 869303005163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869303005164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303005165 Coenzyme A binding pocket [chemical binding]; other site 869303005166 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 869303005167 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869303005168 active site 869303005169 HIGH motif; other site 869303005170 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869303005171 KMSKS motif; other site 869303005172 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869303005173 tRNA binding surface [nucleotide binding]; other site 869303005174 anticodon binding site; other site 869303005175 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 869303005176 active site 869303005177 metal binding site [ion binding]; metal-binding site 869303005178 dimerization interface [polypeptide binding]; other site 869303005179 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 869303005180 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 869303005181 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 869303005183 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869303005184 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869303005185 FtsX-like permease family; Region: FtsX; pfam02687 869303005186 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869303005187 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869303005188 Walker A/P-loop; other site 869303005189 ATP binding site [chemical binding]; other site 869303005190 Q-loop/lid; other site 869303005191 ABC transporter signature motif; other site 869303005192 Walker B; other site 869303005193 D-loop; other site 869303005194 H-loop/switch region; other site 869303005195 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869303005196 FtsX-like permease family; Region: FtsX; pfam02687 869303005197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869303005198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303005199 active site 869303005200 phosphorylation site [posttranslational modification] 869303005201 intermolecular recognition site; other site 869303005202 dimerization interface [polypeptide binding]; other site 869303005203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869303005204 DNA binding site [nucleotide binding] 869303005205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869303005206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869303005207 dimerization interface [polypeptide binding]; other site 869303005208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869303005209 dimer interface [polypeptide binding]; other site 869303005210 phosphorylation site [posttranslational modification] 869303005211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303005212 ATP binding site [chemical binding]; other site 869303005213 Mg2+ binding site [ion binding]; other site 869303005214 G-X-G motif; other site 869303005215 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869303005216 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869303005217 intersubunit interface [polypeptide binding]; other site 869303005218 active site 869303005219 zinc binding site [ion binding]; other site 869303005220 Na+ binding site [ion binding]; other site 869303005222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303005223 dimer interface [polypeptide binding]; other site 869303005224 conserved gate region; other site 869303005225 putative PBP binding loops; other site 869303005226 ABC-ATPase subunit interface; other site 869303005227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303005228 dimer interface [polypeptide binding]; other site 869303005229 conserved gate region; other site 869303005230 putative PBP binding loops; other site 869303005231 ABC-ATPase subunit interface; other site 869303005232 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303005233 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869303005234 substrate binding pocket [chemical binding]; other site 869303005235 membrane-bound complex binding site; other site 869303005236 hinge residues; other site 869303005237 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869303005238 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869303005239 Walker A/P-loop; other site 869303005240 ATP binding site [chemical binding]; other site 869303005241 Q-loop/lid; other site 869303005242 ABC transporter signature motif; other site 869303005243 Walker B; other site 869303005244 D-loop; other site 869303005245 H-loop/switch region; other site 869303005246 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 869303005247 DHH family; Region: DHH; pfam01368 869303005248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 869303005249 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869303005250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869303005251 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869303005252 Predicted esterase [General function prediction only]; Region: COG0627 869303005253 S-formylglutathione hydrolase; Region: PLN02442 869303005254 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 869303005255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 869303005256 FemAB family; Region: FemAB; pfam02388 869303005257 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 869303005258 active site 869303005259 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 869303005260 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 869303005261 GIY-YIG motif/motif A; other site 869303005262 active site 869303005263 catalytic site [active] 869303005264 putative DNA binding site [nucleotide binding]; other site 869303005265 metal binding site [ion binding]; metal-binding site 869303005266 UvrB/uvrC motif; Region: UVR; pfam02151 869303005267 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 869303005268 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869303005269 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 869303005270 active site 869303005271 metal binding site [ion binding]; metal-binding site 869303005272 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869303005273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303005274 substrate binding pocket [chemical binding]; other site 869303005275 membrane-bound complex binding site; other site 869303005276 hinge residues; other site 869303005277 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 869303005278 dimer interface [polypeptide binding]; other site 869303005279 FMN binding site [chemical binding]; other site 869303005280 dipeptidase PepV; Reviewed; Region: PRK07318 869303005281 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 869303005282 active site 869303005283 metal binding site [ion binding]; metal-binding site 869303005284 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 869303005285 putative uracil binding site [chemical binding]; other site 869303005286 putative active site [active] 869303005287 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869303005288 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869303005289 active site residue [active] 869303005290 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 869303005291 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869303005292 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 869303005293 putative oligomer interface [polypeptide binding]; other site 869303005294 putative active site [active] 869303005295 metal binding site [ion binding]; metal-binding site 869303005297 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869303005298 DDE superfamily endonuclease; Region: DDE_4; cl17710 869303005300 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 869303005301 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 869303005302 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 869303005303 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 869303005304 23S rRNA interface [nucleotide binding]; other site 869303005305 L7/L12 interface [polypeptide binding]; other site 869303005306 putative thiostrepton binding site; other site 869303005307 L25 interface [polypeptide binding]; other site 869303005308 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 869303005309 mRNA/rRNA interface [nucleotide binding]; other site 869303005311 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 869303005312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303005313 Walker A/P-loop; other site 869303005314 ATP binding site [chemical binding]; other site 869303005315 Q-loop/lid; other site 869303005316 ABC transporter signature motif; other site 869303005317 Walker B; other site 869303005318 D-loop; other site 869303005319 H-loop/switch region; other site 869303005320 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869303005321 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 869303005322 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 869303005323 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869303005324 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 869303005325 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 869303005326 putative active site [active] 869303005327 catalytic triad [active] 869303005328 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 869303005329 PA/protease or protease-like domain interface [polypeptide binding]; other site 869303005330 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 869303005331 catalytic residues [active] 869303005332 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 869303005333 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 869303005334 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869303005335 active site 869303005336 phosphorylation site [posttranslational modification] 869303005337 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 869303005338 active site 869303005339 P-loop; other site 869303005340 phosphorylation site [posttranslational modification] 869303005341 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 869303005342 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 869303005343 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869303005344 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 869303005345 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869303005346 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 869303005347 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 869303005348 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869303005349 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869303005350 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869303005351 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869303005352 G5 domain; Region: G5; pfam07501 869303005353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869303005354 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869303005355 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869303005356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869303005357 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 869303005358 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 869303005359 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 869303005360 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 869303005361 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869303005362 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869303005363 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 869303005364 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869303005365 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 869303005366 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869303005367 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869303005368 catalytic residues [active] 869303005369 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 869303005370 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 869303005371 SelR domain; Region: SelR; pfam01641 869303005372 Response regulator receiver domain; Region: Response_reg; pfam00072 869303005373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303005374 active site 869303005375 phosphorylation site [posttranslational modification] 869303005376 intermolecular recognition site; other site 869303005377 dimerization interface [polypeptide binding]; other site 869303005378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869303005379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869303005380 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869303005381 Cache domain; Region: Cache_1; pfam02743 869303005382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869303005383 dimerization interface [polypeptide binding]; other site 869303005384 Histidine kinase; Region: His_kinase; pfam06580 869303005385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303005386 ATP binding site [chemical binding]; other site 869303005387 Mg2+ binding site [ion binding]; other site 869303005388 G-X-G motif; other site 869303005389 hypothetical protein; Provisional; Region: PRK13690 869303005390 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869303005391 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 869303005392 G5 domain; Region: G5; pfam07501 869303005393 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 869303005394 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 869303005395 aminodeoxychorismate synthase; Provisional; Region: PRK07508 869303005396 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 869303005397 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 869303005398 substrate-cofactor binding pocket; other site 869303005399 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869303005400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303005401 catalytic residue [active] 869303005402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 869303005403 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869303005404 Excalibur calcium-binding domain; Region: Excalibur; smart00894 869303005405 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 869303005406 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869303005407 nucleotide binding site [chemical binding]; other site 869303005408 thymidylate synthase; Reviewed; Region: thyA; PRK01827 869303005409 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 869303005410 dimerization interface [polypeptide binding]; other site 869303005411 active site 869303005412 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 869303005413 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 869303005414 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 869303005415 GTPases [General function prediction only]; Region: HflX; COG2262 869303005416 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 869303005417 HflX GTPase family; Region: HflX; cd01878 869303005418 G1 box; other site 869303005419 GTP/Mg2+ binding site [chemical binding]; other site 869303005420 Switch I region; other site 869303005421 G2 box; other site 869303005422 G3 box; other site 869303005423 Switch II region; other site 869303005424 G4 box; other site 869303005425 G5 box; other site 869303005426 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 869303005427 ribonuclease Z; Region: RNase_Z; TIGR02651 869303005428 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 869303005429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869303005430 NAD(P) binding site [chemical binding]; other site 869303005431 active site 869303005432 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869303005433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869303005434 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869303005435 dimerization interface [polypeptide binding]; other site 869303005436 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 869303005437 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869303005438 active site residue [active] 869303005439 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869303005440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 869303005441 RNA binding surface [nucleotide binding]; other site 869303005442 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869303005443 active site 869303005444 uracil binding [chemical binding]; other site 869303005445 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 869303005446 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 869303005447 G1 box; other site 869303005448 putative GEF interaction site [polypeptide binding]; other site 869303005449 GTP/Mg2+ binding site [chemical binding]; other site 869303005450 Switch I region; other site 869303005451 G2 box; other site 869303005452 G3 box; other site 869303005453 Switch II region; other site 869303005454 G4 box; other site 869303005455 G5 box; other site 869303005456 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 869303005457 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 869303005458 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 869303005459 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 869303005460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869303005461 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869303005462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303005463 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869303005464 Walker A/P-loop; other site 869303005465 ATP binding site [chemical binding]; other site 869303005466 Q-loop/lid; other site 869303005467 ABC transporter signature motif; other site 869303005468 Walker B; other site 869303005469 D-loop; other site 869303005470 H-loop/switch region; other site 869303005471 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 869303005472 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 869303005473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869303005474 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869303005475 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 869303005476 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 869303005477 homodimer interface [polypeptide binding]; other site 869303005478 active site 869303005479 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 869303005480 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 869303005481 Cell division protein FtsQ; Region: FtsQ; pfam03799 869303005482 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 869303005483 active site 869303005484 dimer interface [polypeptide binding]; other site 869303005485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303005486 active site 869303005487 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869303005488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303005489 Walker A/P-loop; other site 869303005490 ATP binding site [chemical binding]; other site 869303005491 Q-loop/lid; other site 869303005492 ABC transporter signature motif; other site 869303005493 Walker B; other site 869303005494 D-loop; other site 869303005495 H-loop/switch region; other site 869303005496 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 869303005497 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869303005498 substrate binding pocket [chemical binding]; other site 869303005499 membrane-bound complex binding site; other site 869303005500 hinge residues; other site 869303005502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303005503 dimer interface [polypeptide binding]; other site 869303005504 conserved gate region; other site 869303005505 putative PBP binding loops; other site 869303005506 ABC-ATPase subunit interface; other site 869303005507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869303005508 dimer interface [polypeptide binding]; other site 869303005509 conserved gate region; other site 869303005510 putative PBP binding loops; other site 869303005511 ABC-ATPase subunit interface; other site 869303005512 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869303005513 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 869303005514 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 869303005515 dimer interface [polypeptide binding]; other site 869303005516 putative anticodon binding site; other site 869303005517 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 869303005518 motif 1; other site 869303005519 active site 869303005520 motif 2; other site 869303005521 motif 3; other site 869303005522 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 869303005523 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 869303005524 teramer interface [polypeptide binding]; other site 869303005525 active site 869303005526 FMN binding site [chemical binding]; other site 869303005527 catalytic residues [active] 869303005528 Putative transcription activator [Transcription]; Region: TenA; COG0819 869303005529 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869303005530 substrate binding site [chemical binding]; other site 869303005531 multimerization interface [polypeptide binding]; other site 869303005532 ATP binding site [chemical binding]; other site 869303005533 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869303005534 thiamine phosphate binding site [chemical binding]; other site 869303005535 active site 869303005536 pyrophosphate binding site [ion binding]; other site 869303005537 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 869303005538 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869303005539 Walker A/P-loop; other site 869303005540 ATP binding site [chemical binding]; other site 869303005541 ABC transporter; Region: ABC_tran; pfam00005 869303005542 Q-loop/lid; other site 869303005543 ABC transporter signature motif; other site 869303005544 Walker B; other site 869303005545 D-loop; other site 869303005546 H-loop/switch region; other site 869303005547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303005548 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 869303005549 Walker A/P-loop; other site 869303005550 ATP binding site [chemical binding]; other site 869303005551 Q-loop/lid; other site 869303005552 ABC transporter signature motif; other site 869303005553 Walker B; other site 869303005554 D-loop; other site 869303005555 H-loop/switch region; other site 869303005556 Putative transcription activator [Transcription]; Region: TenA; COG0819 869303005557 Predicted membrane protein [Function unknown]; Region: COG4732 869303005558 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869303005559 substrate binding site [chemical binding]; other site 869303005560 multimerization interface [polypeptide binding]; other site 869303005561 ATP binding site [chemical binding]; other site 869303005562 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869303005563 thiamine phosphate binding site [chemical binding]; other site 869303005564 active site 869303005565 pyrophosphate binding site [ion binding]; other site 869303005566 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869303005567 dimer interface [polypeptide binding]; other site 869303005568 substrate binding site [chemical binding]; other site 869303005569 ATP binding site [chemical binding]; other site 869303005570 Predicted transcriptional regulator [Transcription]; Region: COG3682 869303005571 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 869303005572 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 869303005573 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 869303005574 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 869303005575 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 869303005576 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869303005577 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869303005578 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 869303005579 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 869303005580 PYR/PP interface [polypeptide binding]; other site 869303005581 dimer interface [polypeptide binding]; other site 869303005582 tetramer interface [polypeptide binding]; other site 869303005583 TPP binding site [chemical binding]; other site 869303005584 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869303005585 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 869303005586 TPP-binding site [chemical binding]; other site 869303005587 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869303005588 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869303005589 active site 869303005592 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 869303005593 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 869303005594 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 869303005596 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 869303005597 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 869303005598 dimer interface [polypeptide binding]; other site 869303005599 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 869303005600 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869303005601 putative active site [active] 869303005602 nucleotide binding site [chemical binding]; other site 869303005603 nudix motif; other site 869303005604 putative metal binding site [ion binding]; other site 869303005605 HI0933-like protein; Region: HI0933_like; pfam03486 869303005606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 869303005607 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869303005608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869303005609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869303005610 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 869303005611 catalytic motif [active] 869303005612 Zn binding site [ion binding]; other site 869303005613 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869303005614 active site 869303005615 Clp protease; Region: CLP_protease; pfam00574 869303005616 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 869303005617 oligomer interface [polypeptide binding]; other site 869303005618 active site residues [active] 869303005619 hypothetical protein; Provisional; Region: PRK02302 869303005620 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 869303005621 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 869303005622 putative ligand binding site [chemical binding]; other site 869303005623 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869303005624 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 869303005625 TM-ABC transporter signature motif; other site 869303005626 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 869303005627 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 869303005628 TM-ABC transporter signature motif; other site 869303005629 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 869303005630 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 869303005631 Walker A/P-loop; other site 869303005632 ATP binding site [chemical binding]; other site 869303005633 Q-loop/lid; other site 869303005634 ABC transporter signature motif; other site 869303005635 Walker B; other site 869303005636 D-loop; other site 869303005637 H-loop/switch region; other site 869303005638 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 869303005639 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 869303005640 Walker A/P-loop; other site 869303005641 ATP binding site [chemical binding]; other site 869303005642 Q-loop/lid; other site 869303005643 ABC transporter signature motif; other site 869303005644 Walker B; other site 869303005645 D-loop; other site 869303005646 H-loop/switch region; other site 869303005647 FOG: CBS domain [General function prediction only]; Region: COG0517 869303005648 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 869303005649 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 869303005650 peptide chain release factor 2; Validated; Region: prfB; PRK00578 869303005651 PCRF domain; Region: PCRF; pfam03462 869303005652 RF-1 domain; Region: RF-1; pfam00472 869303005653 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 869303005654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869303005655 Walker A/P-loop; other site 869303005656 ATP binding site [chemical binding]; other site 869303005657 Q-loop/lid; other site 869303005658 ABC transporter signature motif; other site 869303005659 Walker B; other site 869303005660 D-loop; other site 869303005661 H-loop/switch region; other site 869303005662 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 869303005663 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 869303005664 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869303005665 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 869303005666 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869303005667 active site turn [active] 869303005668 phosphorylation site [posttranslational modification] 869303005669 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 869303005670 HPr interaction site; other site 869303005671 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869303005672 active site 869303005673 phosphorylation site [posttranslational modification] 869303005674 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 869303005675 putative catalytic site [active] 869303005676 putative metal binding site [ion binding]; other site 869303005677 putative phosphate binding site [ion binding]; other site 869303005678 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869303005679 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869303005680 ATP binding site [chemical binding]; other site 869303005681 Mg++ binding site [ion binding]; other site 869303005682 motif III; other site 869303005683 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869303005684 nucleotide binding region [chemical binding]; other site 869303005685 ATP-binding site [chemical binding]; other site 869303005686 S-adenosylmethionine synthetase; Validated; Region: PRK05250 869303005687 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 869303005688 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 869303005689 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 869303005690 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 869303005691 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 869303005692 active site 869303005693 FMN binding site [chemical binding]; other site 869303005694 substrate binding site [chemical binding]; other site 869303005695 catalytic residues [active] 869303005696 homodimer interface [polypeptide binding]; other site 869303005697 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 869303005698 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 869303005699 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 869303005700 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869303005701 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869303005702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 869303005703 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 869303005704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869303005705 FeS/SAM binding site; other site 869303005706 VanZ like family; Region: VanZ; pfam04892 869303005707 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869303005708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303005709 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303005710 ABC transporter; Region: ABC_tran_2; pfam12848 869303005711 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869303005712 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 869303005713 active site 869303005714 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 869303005715 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 869303005716 KH domain; Region: KH_4; pfam13083 869303005717 G-X-X-G motif; other site 869303005718 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 869303005719 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 869303005720 RimM N-terminal domain; Region: RimM; pfam01782 869303005721 PRC-barrel domain; Region: PRC; pfam05239 869303005722 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 869303005723 ATP cone domain; Region: ATP-cone; pfam03477 869303005724 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 869303005725 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 869303005726 glutathione reductase; Validated; Region: PRK06116 869303005727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869303005728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869303005729 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869303005730 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 869303005731 HlyD family secretion protein; Region: HlyD_3; pfam13437 869303005732 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869303005733 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869303005734 Walker A/P-loop; other site 869303005735 ATP binding site [chemical binding]; other site 869303005736 Q-loop/lid; other site 869303005737 ABC transporter signature motif; other site 869303005738 Walker B; other site 869303005739 D-loop; other site 869303005740 H-loop/switch region; other site 869303005741 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869303005742 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869303005743 FtsX-like permease family; Region: FtsX; pfam02687 869303005744 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 869303005745 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 869303005746 active site 869303005747 HIGH motif; other site 869303005748 KMSKS motif; other site 869303005749 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 869303005750 tRNA binding surface [nucleotide binding]; other site 869303005751 anticodon binding site; other site 869303005752 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 869303005753 dimer interface [polypeptide binding]; other site 869303005754 putative tRNA-binding site [nucleotide binding]; other site 869303005755 Predicted transcriptional regulators [Transcription]; Region: COG1695 869303005756 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869303005757 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869303005758 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869303005759 active site 869303005760 catalytic tetrad [active] 869303005761 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 869303005762 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 869303005763 classical (c) SDRs; Region: SDR_c; cd05233 869303005764 NAD(P) binding site [chemical binding]; other site 869303005765 active site 869303005766 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 869303005767 nudix motif; other site 869303005768 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 869303005769 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 869303005770 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869303005771 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 869303005772 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 869303005773 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 869303005774 Zn binding site [ion binding]; other site 869303005775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869303005776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869303005777 active site 869303005778 phosphorylation site [posttranslational modification] 869303005779 intermolecular recognition site; other site 869303005780 dimerization interface [polypeptide binding]; other site 869303005781 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869303005782 DNA binding site [nucleotide binding] 869303005783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869303005784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869303005785 dimer interface [polypeptide binding]; other site 869303005786 phosphorylation site [posttranslational modification] 869303005787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303005788 ATP binding site [chemical binding]; other site 869303005789 Mg2+ binding site [ion binding]; other site 869303005790 G-X-G motif; other site 869303005791 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 869303005792 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869303005793 Peptidase family U32; Region: Peptidase_U32; pfam01136 869303005794 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 869303005795 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869303005796 active site 869303005797 catalytic site [active] 869303005798 substrate binding site [chemical binding]; other site 869303005799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869303005800 ATP binding site [chemical binding]; other site 869303005801 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 869303005802 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 869303005803 DJ-1 family protein; Region: not_thiJ; TIGR01383 869303005804 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 869303005805 conserved cys residue [active] 869303005806 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 869303005807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303005808 motif II; other site 869303005809 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 869303005810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303005811 Mg2+ binding site [ion binding]; other site 869303005812 G-X-G motif; other site 869303005813 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869303005814 anchoring element; other site 869303005815 dimer interface [polypeptide binding]; other site 869303005816 ATP binding site [chemical binding]; other site 869303005817 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869303005818 active site 869303005819 putative metal-binding site [ion binding]; other site 869303005820 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869303005821 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 869303005823 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 869303005824 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 869303005825 nudix motif; other site 869303005827 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869303005828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303005829 Walker A motif; other site 869303005830 ATP binding site [chemical binding]; other site 869303005831 Walker B motif; other site 869303005832 arginine finger; other site 869303005833 UvrB/uvrC motif; Region: UVR; pfam02151 869303005834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303005835 Walker A motif; other site 869303005836 ATP binding site [chemical binding]; other site 869303005837 Walker B motif; other site 869303005838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869303005839 This gene appears to have been derived through a fusion of permease and ATP-binding subunits of a glutamine-transporting ABC transporter 869303005840 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 869303005841 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 869303005842 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 869303005843 homodimer interface [polypeptide binding]; other site 869303005844 NADP binding site [chemical binding]; other site 869303005845 substrate binding site [chemical binding]; other site 869303005846 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 869303005847 putative substrate binding site [chemical binding]; other site 869303005848 putative ATP binding site [chemical binding]; other site 869303005849 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 869303005850 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869303005851 active site 869303005852 dimer interface [polypeptide binding]; other site 869303005853 phosphopentomutase; Provisional; Region: PRK05362 869303005854 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 869303005855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 869303005856 purine nucleoside phosphorylase; Provisional; Region: PRK08202 869303005858 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 869303005859 topology modulation protein; Provisional; Region: PRK07261 869303005860 AAA domain; Region: AAA_17; pfam13207 869303005861 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 869303005862 pantothenate kinase; Provisional; Region: PRK05439 869303005863 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 869303005864 ATP-binding site [chemical binding]; other site 869303005865 CoA-binding site [chemical binding]; other site 869303005866 Mg2+-binding site [ion binding]; other site 869303005867 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869303005868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303005869 S-adenosylmethionine binding site [chemical binding]; other site 869303005870 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 869303005871 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869303005872 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869303005873 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 869303005874 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 869303005875 intersubunit interface [polypeptide binding]; other site 869303005876 active site 869303005877 catalytic residue [active] 869303005878 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869303005879 active site 869303005880 catalytic motif [active] 869303005881 Zn binding site [ion binding]; other site 869303005882 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 869303005883 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 869303005884 ligand binding site [chemical binding]; other site 869303005885 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 869303005886 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869303005887 Walker A/P-loop; other site 869303005888 ATP binding site [chemical binding]; other site 869303005889 Q-loop/lid; other site 869303005890 ABC transporter signature motif; other site 869303005891 Walker B; other site 869303005892 D-loop; other site 869303005893 H-loop/switch region; other site 869303005894 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869303005895 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869303005896 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869303005897 TM-ABC transporter signature motif; other site 869303005898 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869303005899 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869303005900 TM-ABC transporter signature motif; other site 869303005903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869303005904 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869303005905 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 869303005906 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 869303005907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869303005908 Mg2+ binding site [ion binding]; other site 869303005909 G-X-G motif; other site 869303005910 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869303005911 anchoring element; other site 869303005912 dimer interface [polypeptide binding]; other site 869303005913 ATP binding site [chemical binding]; other site 869303005914 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869303005915 active site 869303005916 putative metal-binding site [ion binding]; other site 869303005917 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869303005918 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 869303005919 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869303005920 CAP-like domain; other site 869303005921 active site 869303005922 primary dimer interface [polypeptide binding]; other site 869303005923 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869303005924 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 869303005925 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 869303005926 homodimer interface [polypeptide binding]; other site 869303005927 substrate-cofactor binding pocket; other site 869303005928 catalytic residue [active] 869303005929 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869303005930 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869303005931 Predicted membrane protein [Function unknown]; Region: COG3819 869303005932 Predicted membrane protein [Function unknown]; Region: COG3817 869303005933 Protein of unknown function (DUF979); Region: DUF979; pfam06166 869303005934 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 869303005935 putative substrate binding pocket [chemical binding]; other site 869303005936 AC domain interface; other site 869303005937 catalytic triad [active] 869303005938 AB domain interface; other site 869303005939 interchain disulfide; other site 869303005940 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 869303005941 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 869303005942 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 869303005943 RNA binding site [nucleotide binding]; other site 869303005944 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 869303005945 RNA binding site [nucleotide binding]; other site 869303005946 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 869303005947 RNA binding site [nucleotide binding]; other site 869303005948 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 869303005949 RNA binding site [nucleotide binding]; other site 869303005951 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 869303005952 GAF domain; Region: GAF_2; pfam13185 869303005953 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 869303005954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869303005955 Walker A motif; other site 869303005956 ATP binding site [chemical binding]; other site 869303005957 Walker B motif; other site 869303005958 arginine finger; other site 869303005959 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 869303005960 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 869303005961 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 869303005962 Walker A/P-loop; other site 869303005963 ATP binding site [chemical binding]; other site 869303005964 Q-loop/lid; other site 869303005965 ABC transporter signature motif; other site 869303005966 Walker B; other site 869303005967 D-loop; other site 869303005968 H-loop/switch region; other site 869303005969 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 869303005970 FeS assembly protein SufD; Region: sufD; TIGR01981 869303005971 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 869303005972 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 869303005973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869303005974 catalytic residue [active] 869303005975 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 869303005976 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 869303005977 trimerization site [polypeptide binding]; other site 869303005978 active site 869303005979 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 869303005980 FeS assembly protein SufB; Region: sufB; TIGR01980 869303005981 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 869303005982 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 869303005983 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 869303005984 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869303005985 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869303005986 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869303005987 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 869303005988 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869303005989 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 869303005990 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869303005991 putative substrate binding site [chemical binding]; other site 869303005992 putative ATP binding site [chemical binding]; other site 869303005993 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 869303005994 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869303005995 active site 869303005996 phosphorylation site [posttranslational modification] 869303005997 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869303005998 active site 869303005999 P-loop; other site 869303006000 phosphorylation site [posttranslational modification] 869303006001 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869303006002 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 869303006003 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 869303006004 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869303006005 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 869303006006 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869303006007 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869303006008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869303006009 catalytic residue [active] 869303006010 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 869303006011 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 869303006012 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 869303006013 Ligand Binding Site [chemical binding]; other site 869303006014 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 869303006015 Putative esterase; Region: Esterase; pfam00756 869303006016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 869303006017 Putative esterase; Region: Esterase; pfam00756 869303006019 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869303006020 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869303006021 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869303006022 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 869303006023 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 869303006024 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 869303006025 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 869303006026 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869303006027 active site 869303006028 catalytic residues [active] 869303006029 DNA binding site [nucleotide binding] 869303006030 Int/Topo IB signature motif; other site 869303006031 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869303006032 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869303006034 Arginine repressor [Transcription]; Region: ArgR; COG1438 869303006035 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869303006036 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869303006037 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 869303006038 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 869303006039 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 869303006040 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 869303006041 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 869303006042 active site 869303006043 PHP Thumb interface [polypeptide binding]; other site 869303006044 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 869303006045 generic binding surface II; other site 869303006046 generic binding surface I; other site 869303006047 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 869303006048 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 869303006049 active site 869303006050 ADP/pyrophosphate binding site [chemical binding]; other site 869303006051 dimerization interface [polypeptide binding]; other site 869303006052 allosteric effector site; other site 869303006053 fructose-1,6-bisphosphate binding site; other site 869303006054 pyruvate kinase; Provisional; Region: PRK05826 869303006055 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 869303006056 domain interfaces; other site 869303006057 active site 869303006059 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 869303006060 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869303006061 Predicted membrane protein [Function unknown]; Region: COG3689 869303006062 Predicted permeases [General function prediction only]; Region: COG0701 869303006063 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 869303006064 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 869303006065 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 869303006066 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 869303006067 RNA binding site [nucleotide binding]; other site 869303006068 SprT homologues; Region: SprT; cl01182 869303006069 hypothetical protein; Provisional; Region: PRK04351 869303006070 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 869303006071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869303006072 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869303006073 Walker A/P-loop; other site 869303006074 ATP binding site [chemical binding]; other site 869303006075 Q-loop/lid; other site 869303006076 ABC transporter signature motif; other site 869303006077 Walker B; other site 869303006078 D-loop; other site 869303006079 H-loop/switch region; other site 869303006080 FtsX-like permease family; Region: FtsX; pfam02687 869303006081 disrupted by IS insertion 869303006083 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 869303006084 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 869303006085 homodimer interface [polypeptide binding]; other site 869303006086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869303006087 catalytic residue [active] 869303006088 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869303006089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 869303006090 Transposase; Region: DEDD_Tnp_IS110; pfam01548 869303006091 spermidine synthase; Provisional; Region: PRK00811 869303006092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303006093 S-adenosylmethionine binding site [chemical binding]; other site 869303006094 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 869303006095 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 869303006096 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 869303006097 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 869303006098 dimer interface [polypeptide binding]; other site 869303006099 active site 869303006100 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869303006101 catalytic residues [active] 869303006102 substrate binding site [chemical binding]; other site 869303006103 agmatine deiminase; Provisional; Region: PRK13551 869303006104 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 869303006105 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 869303006106 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 869303006107 putative active site; other site 869303006108 catalytic triad [active] 869303006109 putative dimer interface [polypeptide binding]; other site 869303006110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303006111 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869303006112 active site 869303006113 motif I; other site 869303006114 motif II; other site 869303006115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869303006116 CAAX protease self-immunity; Region: Abi; pfam02517 869303006117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869303006118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869303006119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869303006120 dimerization interface [polypeptide binding]; other site 869303006121 lipoprotein signal peptidase; Provisional; Region: PRK14797 869303006122 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869303006123 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869303006124 RNA binding surface [nucleotide binding]; other site 869303006125 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869303006126 active site 869303006127 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 869303006128 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869303006129 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869303006130 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 869303006131 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 869303006132 nucleotide binding site [chemical binding]; other site 869303006133 homotetrameric interface [polypeptide binding]; other site 869303006134 putative phosphate binding site [ion binding]; other site 869303006135 putative allosteric binding site; other site 869303006136 PUA domain; Region: PUA; pfam01472 869303006137 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 869303006138 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 869303006139 putative catalytic cysteine [active] 869303006140 pyrroline-5-carboxylate reductase; Region: PLN02688 869303006141 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 869303006142 thymidylate kinase; Validated; Region: tmk; PRK00698 869303006143 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869303006144 TMP-binding site; other site 869303006145 ATP-binding site [chemical binding]; other site 869303006146 DNA polymerase III subunit delta'; Validated; Region: PRK07276 869303006147 DNA polymerase III subunit delta'; Validated; Region: PRK08485 869303006148 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 869303006149 Predicted methyltransferases [General function prediction only]; Region: COG0313 869303006150 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 869303006151 putative SAM binding site [chemical binding]; other site 869303006152 putative homodimer interface [polypeptide binding]; other site 869303006153 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 869303006154 Glucose inhibited division protein A; Region: GIDA; pfam01134 869303006155 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 869303006156 putative nucleotide binding site [chemical binding]; other site 869303006157 uridine monophosphate binding site [chemical binding]; other site 869303006158 homohexameric interface [polypeptide binding]; other site 869303006159 ribosome recycling factor; Reviewed; Region: frr; PRK00083 869303006160 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 869303006161 hinge region; other site 869303006163 hypothetical protein; Provisional; Region: PRK13672 869303006164 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 869303006165 PhoH-like protein; Region: PhoH; pfam02562 869303006166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869303006167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869303006168 Coenzyme A binding pocket [chemical binding]; other site 869303006169 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 869303006171 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869303006172 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869303006173 SLBB domain; Region: SLBB; pfam10531 869303006174 comEA protein; Region: comE; TIGR01259 869303006175 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 869303006176 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 869303006177 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 869303006178 Competence protein; Region: Competence; pfam03772 869303006179 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 869303006180 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869303006181 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869303006182 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869303006183 Walker A/P-loop; other site 869303006184 ATP binding site [chemical binding]; other site 869303006185 Q-loop/lid; other site 869303006186 ABC transporter signature motif; other site 869303006187 Walker B; other site 869303006188 D-loop; other site 869303006189 H-loop/switch region; other site 869303006190 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 869303006191 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 869303006192 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 869303006193 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 869303006194 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 869303006195 23S rRNA binding site [nucleotide binding]; other site 869303006196 L21 binding site [polypeptide binding]; other site 869303006197 L13 binding site [polypeptide binding]; other site 869303006198 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869303006199 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 869303006200 dimer interface [polypeptide binding]; other site 869303006201 active site 869303006202 metal binding site [ion binding]; metal-binding site 869303006203 glutathione binding site [chemical binding]; other site 869303006204 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 869303006205 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 869303006206 FAD binding pocket [chemical binding]; other site 869303006207 FAD binding motif [chemical binding]; other site 869303006208 phosphate binding motif [ion binding]; other site 869303006209 beta-alpha-beta structure motif; other site 869303006210 NAD binding pocket [chemical binding]; other site 869303006211 Iron coordination center [ion binding]; other site 869303006212 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 869303006213 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 869303006214 heterodimer interface [polypeptide binding]; other site 869303006215 active site 869303006216 FMN binding site [chemical binding]; other site 869303006217 homodimer interface [polypeptide binding]; other site 869303006218 substrate binding site [chemical binding]; other site 869303006219 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869303006220 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 869303006221 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 869303006222 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 869303006223 Domain of unknown function (DUF814); Region: DUF814; pfam05670 869303006224 metal-binding heat shock protein; Provisional; Region: PRK00016 869303006225 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 869303006226 GTPase Era; Reviewed; Region: era; PRK00089 869303006227 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 869303006228 G1 box; other site 869303006229 GTP/Mg2+ binding site [chemical binding]; other site 869303006230 Switch I region; other site 869303006231 G2 box; other site 869303006232 Switch II region; other site 869303006233 G3 box; other site 869303006234 G4 box; other site 869303006235 G5 box; other site 869303006236 KH domain; Region: KH_2; pfam07650 869303006237 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 869303006238 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 869303006239 DNA binding site [nucleotide binding] 869303006240 catalytic residue [active] 869303006241 H2TH interface [polypeptide binding]; other site 869303006242 putative catalytic residues [active] 869303006243 turnover-facilitating residue; other site 869303006244 intercalation triad [nucleotide binding]; other site 869303006245 8OG recognition residue [nucleotide binding]; other site 869303006246 putative reading head residues; other site 869303006247 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 869303006248 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869303006249 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 869303006250 dephospho-CoA kinase; Region: TIGR00152 869303006251 CoA-binding site [chemical binding]; other site 869303006252 ATP-binding [chemical binding]; other site 869303006253 drug efflux system protein MdtG; Provisional; Region: PRK09874 869303006254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869303006255 putative substrate translocation pore; other site 869303006256 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869303006257 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 869303006258 ribonuclease R; Region: RNase_R; TIGR02063 869303006259 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 869303006260 RNB domain; Region: RNB; pfam00773 869303006261 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 869303006262 RNA binding site [nucleotide binding]; other site 869303006263 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 869303006264 SmpB-tmRNA interface; other site 869303006265 tellurite resistance protein TehB; Provisional; Region: PRK12335 869303006266 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 869303006267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303006268 S-adenosylmethionine binding site [chemical binding]; other site 869303006269 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 869303006270 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 869303006271 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 869303006272 active site 869303006273 Zn binding site [ion binding]; other site 869303006274 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 869303006275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869303006276 S-adenosylmethionine binding site [chemical binding]; other site 869303006277 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 869303006278 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 869303006282 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869303006283 catalytic core [active] 869303006284 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 869303006285 putative deacylase active site [active] 869303006286 Predicted membrane protein [Function unknown]; Region: COG2035 869303006287 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 869303006288 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 869303006289 active site 869303006290 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 869303006291 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 869303006292 Substrate binding site; other site 869303006293 Mg++ binding site; other site 869303006294 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 869303006295 active site 869303006296 substrate binding site [chemical binding]; other site 869303006297 CoA binding site [chemical binding]; other site 869303006298 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869303006299 dimer interface [polypeptide binding]; other site 869303006300 ADP-ribose binding site [chemical binding]; other site 869303006301 active site 869303006302 nudix motif; other site 869303006303 metal binding site [ion binding]; metal-binding site 869303006304 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 869303006305 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 869303006306 MarR family; Region: MarR_2; cl17246 869303006307 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 869303006308 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869303006309 active site 869303006310 catalytic site [active] 869303006311 substrate binding site [chemical binding]; other site 869303006312 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 869303006313 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 869303006314 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 869303006315 putative active site [active] 869303006316 catalytic site [active] 869303006317 putative metal binding site [ion binding]; other site 869303006319 Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045 869303006320 dimer interface [polypeptide binding]; other site 869303006321 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869303006322 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 869303006323 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869303006324 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869303006325 catalytic residues [active] 869303006326 amino acid transporter; Region: 2A0306; TIGR00909 869303006327 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 869303006328 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869303006329 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 869303006330 metal binding site [ion binding]; metal-binding site 869303006332 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869303006333 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869303006334 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869303006335 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869303006336 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869303006340 peptidase T; Region: peptidase-T; TIGR01882 869303006341 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 869303006342 metal binding site [ion binding]; metal-binding site 869303006343 dimer interface [polypeptide binding]; other site 869303006344 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 869303006345 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 869303006346 C-terminal domain interface [polypeptide binding]; other site 869303006347 active site 869303006348 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 869303006349 active site 869303006350 N-terminal domain interface [polypeptide binding]; other site 869303006351 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 869303006352 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 869303006353 Predicted membrane protein [Function unknown]; Region: COG2246 869303006354 GtrA-like protein; Region: GtrA; pfam04138 869303006355 Predicted membrane protein [Function unknown]; Region: COG4708