-- dump date 20140620_084511 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 373153000001 SEQ_END SEQ_END NC_008533.1 2046115 2046115 DR NC_008533.1; contig end 2046115..2046115 Streptococcus pneumoniae D39 YP_815417.1 CDS dnaA NC_008533.1 1 1362 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1..1362 Streptococcus pneumoniae D39 4442762 YP_815419.1 CDS dnaN NC_008533.1 1521 2657 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1521..2657 Streptococcus pneumoniae D39 4442015 YP_815421.1 CDS SPD_0003 NC_008533.1 2722 2916 D equivalent gene in S.pneumoniae TIGR4 = SP0003; equivalent gene in S.pneumoniae R6 = spr0003; identified by match to protein family HMM PF06107; hypothetical protein 2722..2916 Streptococcus pneumoniae D39 4441542 YP_815423.1 CDS SPD_0004 NC_008533.1 3000 4115 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3000..4115 Streptococcus pneumoniae D39 4442821 YP_815426.1 CDS pth NC_008533.1 4186 4755 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4186..4755 Streptococcus pneumoniae D39 4441019 YP_815427.1 CDS mfd NC_008533.1 4756 8265 D equivalent gene in S.pneumoniae TIGR4 = SP0006; equivalent gene in S.pneumoniae R6 = spr0006; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 4756..8265 Streptococcus pneumoniae D39 4442513 YP_815429.1 CDS SPD_0007 NC_008533.1 8323 8589 D equivalent gene in S.pneumoniae TIGR4 = SP0007; equivalent gene in S.pneumoniae R6 = spr0007; identified by match to protein family HMM PF01479; S4 domain-containing protein 8323..8589 Streptococcus pneumoniae D39 4442715 YP_815431.1 CDS SPD_0008 NC_008533.1 8582 8950 D equivalent gene in S.pneumoniae TIGR4 = SP0008; equivalent gene in S.pneumoniae R6 = spr0008; identified by match to protein family HMM PF04977; hypothetical protein 8582..8950 Streptococcus pneumoniae D39 4442430 YP_815432.1 CDS SPD_0009 NC_008533.1 8955 9077 D equivalent gene in S.pneumoniae TIGR4 = SP0009; hypothetical protein 8955..9077 Streptococcus pneumoniae D39 4442160 YP_815433.1 CDS SPD_0010 NC_008533.1 9070 10338 D equivalent gene in S.pneumoniae TIGR4 = SP0010; equivalent gene in S.pneumoniae R6 = spr0009; hypothetical protein 9070..10338 Streptococcus pneumoniae D39 4441394 YP_815434.1 CDS tilS NC_008533.1 10335 11612 D equivalent gene in S.pneumoniae TIGR4 = SP0011; equivalent gene in S.pneumoniae R6 = spr0010; identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthetase 10335..11612 Streptococcus pneumoniae D39 4442234 YP_815435.1 CDS hpt NC_008533.1 11616 12158 D equivalent gene in S.pneumoniae TIGR4 = SP0012; equivalent gene in S.pneumoniae R6 = spr0011; identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine-guanine phosphoribosyltransferase 11616..12158 Streptococcus pneumoniae D39 4441355 YP_815436.1 CDS ftsH NC_008533.1 12174 14132 D equivalent gene in S.pneumoniae TIGR4 = SP0013; equivalent gene in S.pneumoniae R6 = spr0012; identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241; cell division protein FtsH 12174..14132 Streptococcus pneumoniae D39 4441207 YP_815437.1 CDS comX1 NC_008533.1 14254 14733 D equivalent gene in S.pneumoniae TIGR4 = SP0014; equivalent gene in S.pneumoniae R6 = spr0013; transcriptional regulator ComX1 14254..14733 Streptococcus pneumoniae D39 4441078 YP_815438.1 CDS SPD_0023 NC_008533.1 22168 22404 D equivalent gene in S.pneumoniae TIGR4 = SP0018; equivalent gene in S.pneumoniae R6 = spr0020; hypothetical protein 22168..22404 Streptococcus pneumoniae D39 4441397 YP_815439.1 CDS purA NC_008533.1 22635 23921 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 22635..23921 Streptococcus pneumoniae D39 4441672 YP_815440.1 CDS SPD_0025 NC_008533.1 24122 24589 D equivalent gene in S.pneumoniae TIGR4 = SP0020; equivalent gene in S.pneumoniae R6 = spr0022; identified by match to protein family HMM PF00383; cytidine/deoxycytidylate deaminase family protein 24122..24589 Streptococcus pneumoniae D39 4442398 YP_815441.1 CDS dut NC_008533.1 24776 25219 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 24776..25219 Streptococcus pneumoniae D39 4441073 YP_815442.1 CDS SPD_0028 NC_008533.1 25179 25736 D equivalent gene in S.pneumoniae TIGR4 = SP0022; equivalent gene in S.pneumoniae R6 = spr0024; identified by match to protein family HMM PF00300; hypothetical protein 25179..25736 Streptococcus pneumoniae D39 4442141 YP_815444.1 CDS radA NC_008533.1 25849 27111 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 25849..27111 Streptococcus pneumoniae D39 4441523 YP_815447.1 CDS SPD_0030 NC_008533.1 27184 27681 D equivalent gene in S.pneumoniae TIGR4 = SP0024; equivalent gene in S.pneumoniae R6 = spr0026; identified by match to protein family HMM PF00484; hypothetical protein 27184..27681 Streptococcus pneumoniae D39 4441187 YP_815449.1 CDS SPD_0031 NC_008533.1 27706 28365 D equivalent gene in S.pneumoniae TIGR4 = SP0026; equivalent gene in S.pneumoniae R6 = spr0027; hypothetical protein 27706..28365 Streptococcus pneumoniae D39 4442584 YP_815451.1 CDS SPD_0032 NC_008533.1 28358 28489 D equivalent gene in S.pneumoniae TIGR4 = SP0026; hypothetical protein 28358..28489 Streptococcus pneumoniae D39 4441554 YP_815453.1 CDS prsA NC_008533.1 28634 29602 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 28634..29602 Streptococcus pneumoniae D39 4442386 YP_815455.1 CDS SPD_0035 NC_008533.1 30143 30376 R equivalent gene in S.pneumoniae TIGR4 = SP0029; equivalent gene in S.pneumoniae R6 = spr0030; hypothetical protein complement(30143..30376) Streptococcus pneumoniae D39 4442175 YP_815457.1 CDS SPD_0036 NC_008533.1 30369 30485 R hypothetical protein complement(30369..30485) Streptococcus pneumoniae D39 4441144 YP_815459.1 CDS SPD_0037 NC_008533.1 30700 31053 R equivalent gene in S.pneumoniae TIGR4 = SP0031; equivalent gene in S.pneumoniae R6 = spr0031; hypothetical protein complement(30700..31053) Streptococcus pneumoniae D39 4441985 YP_815461.1 CDS SPD_0038 NC_008533.1 31306 33939 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 31306..33939 Streptococcus pneumoniae D39 4443058 YP_815463.1 CDS SPD_0039 NC_008533.1 34024 34461 D equivalent gene in S.pneumoniae TIGR4 = SP0033; equivalent gene in S.pneumoniae R6 = spr0033; identified by match to protein family HMM PF02629; hypothetical protein 34024..34461 Streptococcus pneumoniae D39 4442658 YP_815466.1 CDS SPD_0040 NC_008533.1 34652 35662 R equivalent gene in S.pneumoniae TIGR4 = SP0034; equivalent gene in S.pneumoniae R6 = spr0034; identified by match to protein family HMM PF03601; hypothetical protein complement(34652..35662) Streptococcus pneumoniae D39 4443021 YP_815468.1 CDS araT NC_008533.1 35811 36980 D catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 35811..36980 Streptococcus pneumoniae D39 4442501 YP_815471.1 CDS recO NC_008533.1 36977 37747 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 36977..37747 Streptococcus pneumoniae D39 4441827 YP_815473.1 CDS plsX NC_008533.1 37744 38736 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 37744..38736 Streptococcus pneumoniae D39 4441058 YP_815476.1 CDS SPD_0044 NC_008533.1 38742 38975 D equivalent gene in S.pneumoniae TIGR4 = SP0038; equivalent gene in S.pneumoniae R6 = spr0038; acyl carrier protein 38742..38975 Streptococcus pneumoniae D39 4442744 YP_815478.1 CDS blpU NC_008533.1 39514 39744 D equivalent gene in S.pneumoniae TIGR4 = SP0041; equivalent gene in S.pneumoniae R6 = spr0040; identified by match to protein family HMM TIGR01847; bacteriocin BlpU 39514..39744 Streptococcus pneumoniae D39 4442082 YP_815481.1 CDS SPD_0047 NC_008533.1 39747 39872 D hypothetical protein 39747..39872 Streptococcus pneumoniae D39 4442850 YP_815482.1 CDS comA NC_008533.1 41902 44055 D equivalent gene in S.pneumoniae TIGR4 = SP0042; equivalent gene in S.pneumoniae R6 = spr0043; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; competence factor transporting ATP-binding protein/permease ComA 41902..44055 Streptococcus pneumoniae D39 4442631 YP_815485.1 CDS comB NC_008533.1 44068 45417 D equivalent gene in S.pneumoniae TIGR4 = SP0043; equivalent gene in S.pneumoniae R6 = spr0044; identified by match to protein family HMM TIGR01000; competence factor transport protein ComB 44068..45417 Streptococcus pneumoniae D39 4441443 YP_815487.1 CDS purC NC_008533.1 45587 46294 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 45587..46294 Streptococcus pneumoniae D39 4441147 YP_815489.1 CDS SPD_0052 NC_008533.1 46496 50221 D equivalent gene in S.pneumoniae TIGR4 = SP0045; equivalent gene in S.pneumoniae R6 = spr0046; identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857; phosphoribosylformylglycinamidine synthase 46496..50221 Streptococcus pneumoniae D39 4442624 YP_815491.1 CDS purF NC_008533.1 50314 51756 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 50314..51756 Streptococcus pneumoniae D39 4441346 YP_815493.1 CDS purM NC_008533.1 51793 52815 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 51793..52815 Streptococcus pneumoniae D39 4441023 YP_815495.1 CDS purN NC_008533.1 52812 53357 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 52812..53357 Streptococcus pneumoniae D39 4441567 YP_815498.1 CDS SPD_0056 NC_008533.1 53441 53950 D equivalent gene in S.pneumoniae TIGR4 = SP0049; equivalent gene in S.pneumoniae R6 = spr0050; identified by match to protein family HMM PF04892; vanZ protein 53441..53950 Streptococcus pneumoniae D39 4442075 YP_815500.1 CDS purH NC_008533.1 53975 55522 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 53975..55522 Streptococcus pneumoniae D39 4442771 YP_815502.1 CDS purD NC_008533.1 55644 56906 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 55644..56906 Streptococcus pneumoniae D39 4442370 YP_815504.1 CDS purE NC_008533.1 57309 57797 D equivalent gene in S.pneumoniae TIGR4 = SP0053; equivalent gene in S.pneumoniae R6 = spr0053; identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase catalytic subunit 57309..57797 Streptococcus pneumoniae D39 4441676 YP_815506.1 CDS purK NC_008533.1 57784 58875 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 57784..58875 Streptococcus pneumoniae D39 4441599 YP_815508.1 CDS SPD_0061 NC_008533.1 58885 59112 D equivalent gene in S.pneumoniae TIGR4 = SP0055; equivalent gene in S.pneumoniae R6 = spr0055; hypothetical protein 58885..59112 Streptococcus pneumoniae D39 4442025 YP_815510.1 CDS purB NC_008533.1 59175 60473 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 59175..60473 Streptococcus pneumoniae D39 4442401 YP_815512.1 CDS strH NC_008533.1 60528 64466 R equivalent gene in S.pneumoniae TIGR4 = SP0057; equivalent gene in S.pneumoniae R6 = spr0057; identified by match to protein family HMM PF00728; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-N-acetylhexosaminidase complement(60528..64466) Streptococcus pneumoniae D39 4442356 YP_815514.1 CDS SPD_0064 NC_008533.1 64781 65524 R equivalent gene in S.pneumoniae TIGR4 = SP0058; equivalent gene in S.pneumoniae R6 = spr0058; identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator protein complement(64781..65524) Streptococcus pneumoniae D39 4441392 YP_815516.1 CDS bgaC NC_008533.1 65845 67632 D equivalent gene in S.pneumoniae TIGR4 = SP0060; equivalent gene in S.pneumoniae R6 = spr0059; identified by match to protein family HMM PF01301; match to protein family HMM PF02449; Beta-galactosidase 3 65845..67632 Streptococcus pneumoniae D39 4441811 YP_815518.1 CDS SPD_0066 NC_008533.1 67629 68105 D equivalent gene in S.pneumoniae TIGR4 = SP0061; equivalent gene in S.pneumoniae R6 = spr0060; identified by match to protein family HMM PF03830; PTS system transporter subunit IIB 67629..68105 Streptococcus pneumoniae D39 4442511 YP_815520.1 CDS SPD_0067 NC_008533.1 68133 69038 D equivalent gene in S.pneumoniae TIGR4 = SP0062; equivalent gene in S.pneumoniae R6 = spr0061; identified by match to protein family HMM PF03609; PTS system transporter subunit IIC 68133..69038 Streptococcus pneumoniae D39 4442745 YP_815521.1 CDS SPD_0068 NC_008533.1 69025 69840 D equivalent gene in S.pneumoniae TIGR4 = SP0063; equivalent gene in S.pneumoniae R6 = spr0062; identified by match to protein family HMM PF03613; PTS system transporter subunit IID 69025..69840 Streptococcus pneumoniae D39 4442668 YP_815523.1 CDS SPD_0069 NC_008533.1 69847 70251 D equivalent gene in S.pneumoniae TIGR4 = SP0064; equivalent gene in S.pneumoniae R6 = spr0063; identified by match to protein family HMM PF03610; PTS system transporter subunit IIA 69847..70251 Streptococcus pneumoniae D39 4441602 YP_815524.1 CDS agaS NC_008533.1 70550 71716 D equivalent gene in S.pneumoniae TIGR4 = SP0065; equivalent gene in S.pneumoniae R6 = spr0064; identified by match to protein family HMM PF01380; sugar isomerase 70550..71716 Streptococcus pneumoniae D39 4442993 YP_815527.1 CDS galM NC_008533.1 71832 72869 D equivalent gene in S.pneumoniae TIGR4 = SP0066; equivalent gene in S.pneumoniae R6 = spr0065; identified by match to protein family HMM PF01263; aldose 1-epimerase 71832..72869 Streptococcus pneumoniae D39 4441851 YP_815529.1 CDS SPD_0072 NC_008533.1 73076 73930 D equivalent gene in S.pneumoniae R6 = spr0066; identified by match to protein family HMM PF00903; hypothetical protein 73076..73930 Streptococcus pneumoniae D39 4441887 YP_815531.1 CDS SPD_0073 NC_008533.1 74080 74337 D equivalent gene in S.pneumoniae R6 = spr0067; identified by match to protein family HMM PF02583; hypothetical protein 74080..74337 Streptococcus pneumoniae D39 4441126 YP_815532.1 CDS SPD_0074 NC_008533.1 75312 76076 D equivalent gene in S.pneumoniae TIGR4 = SP0075; equivalent gene in S.pneumoniae R6 = spr0068; identified by match to protein family HMM PF01048; phosphorylase, Pnp/Udp family protein 75312..76076 Streptococcus pneumoniae D39 4441269 YP_815535.1 CDS SPD_0075 NC_008533.1 76332 76517 D hypothetical protein 76332..76517 Streptococcus pneumoniae D39 4441760 YP_815537.1 CDS SPD_0076 NC_008533.1 76686 78065 D equivalent gene in S.pneumoniae TIGR4 = SP0078; equivalent gene in S.pneumoniae R6 = spr0070; identified by match to protein family HMM PF02386; potassium uptake protein, Trk family protein 76686..78065 Streptococcus pneumoniae D39 4442195 YP_815540.1 CDS SPD_0077 NC_008533.1 78079 78744 D equivalent gene in S.pneumoniae TIGR4 = SP0079; equivalent gene in S.pneumoniae R6 = spr0071; identified by match to protein family HMM PF02254; potassium uptake protein, Trk family protein 78079..78744 Streptococcus pneumoniae D39 4441539 YP_815541.1 CDS SPD_0078 NC_008533.1 79054 79593 D equivalent gene in S.pneumoniae R6 = spr0072; identified by match to protein family HMM PF00535; glycosyl transferase family protein 79054..79593 Streptococcus pneumoniae D39 4441860 YP_815545.1 CDS SPD_0079 NC_008533.1 79660 80070 D equivalent gene in S.pneumoniae R6 = spr0074; hypothetical protein 79660..80070 Streptococcus pneumoniae D39 4442691 YP_815547.1 CDS SPD_0080 NC_008533.1 80186 83671 D equivalent gene in S.pneumoniae R6 = spr0075; contains 6 repeats of 456-bp SSURE domain, exact sequence of repeats could not be determined. Placeholder sequence was inserted containing the 5 repeats used previously in spr0075 in the R6 genome sequence; identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 80186..83671 Streptococcus pneumoniae D39 4441283 YP_815548.1 CDS SPD_0081 NC_008533.1 83838 84536 D equivalent gene in S.pneumoniae TIGR4 = SP0083; equivalent gene in S.pneumoniae R6 = spr0076; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 83838..84536 Streptococcus pneumoniae D39 4442307 YP_815550.1 CDS SPD_0082 NC_008533.1 84533 85585 D equivalent gene in S.pneumoniae TIGR4 = SP0084; equivalent gene in S.pneumoniae R6 = spr0077; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase 84533..85585 Streptococcus pneumoniae D39 4442488 YP_815552.1 CDS rpsD NC_008533.1 85780 86391 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 85780..86391 Streptococcus pneumoniae D39 4442104 YP_815554.1 CDS SPD_0084 NC_008533.1 86577 86735 D equivalent gene in S.pneumoniae TIGR4 = SP0086; equivalent gene in S.pneumoniae R6 = spr0014 In TIGR4 this gene is annotated as a truncation; however in R6 there are numerous near perfect copies as well as copies with a slightly longer version with a different end that is not present in either R6 or TIGR4 This indicates it may still function as a transposase.; IS630-Spn1, transposase Orf1 86577..86735 Streptococcus pneumoniae D39 4441035 YP_815557.1 CDS SPD_0085 NC_008533.1 86833 86973 R equivalent gene in S.pneumoniae TIGR4 = SP0087; hypothetical protein complement(86833..86973) Streptococcus pneumoniae D39 4443026 YP_815560.1 CDS SPD_0086 NC_008533.1 87053 87313 D equivalent gene in S.pneumoniae TIGR4 = SP0088; equivalent gene in S.pneumoniae R6 = spr0080; hypothetical protein 87053..87313 Streptococcus pneumoniae D39 4443013 YP_815562.1 CDS SPD_0087 NC_008533.1 87267 87488 D equivalent gene in S.pneumoniae TIGR4 = SP0089; hypothetical protein 87267..87488 Streptococcus pneumoniae D39 4442934 YP_815564.1 CDS SPD_0088 NC_008533.1 87807 88736 D equivalent gene in S.pneumoniae TIGR4 = SP0090; equivalent gene in S.pneumoniae R6 = spr0081; identified by match to protein family HMM PF00528; ABC transporter permease 87807..88736 Streptococcus pneumoniae D39 4442485 YP_815566.1 CDS SPD_0089 NC_008533.1 88750 89673 D equivalent gene in S.pneumoniae TIGR4 = SP0091; equivalent gene in S.pneumoniae R6 = spr0082; identified by match to protein family HMM PF00528; ABC transporter permease 88750..89673 Streptococcus pneumoniae D39 4442292 YP_815568.1 CDS SPD_0090 NC_008533.1 89931 91406 D equivalent gene in S.pneumoniae TIGR4 = SP0092; equivalent gene in S.pneumoniae R6 = spr0083; identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 89931..91406 Streptococcus pneumoniae D39 4442042 YP_815571.1 CDS SPD_0091 NC_008533.1 91678 92664 D equivalent gene in S.pneumoniae TIGR4 = SP0095; equivalent gene in S.pneumoniae R6 = spr0084; identified by match to protein family HMM PF00581; hypothetical protein 91678..92664 Streptococcus pneumoniae D39 4442371 YP_815572.1 CDS SPD_0092 NC_008533.1 92786 93646 D equivalent gene in S.pneumoniae TIGR4 = SP0096; equivalent gene in S.pneumoniae R6 = spr0085; hypothetical protein 92786..93646 Streptococcus pneumoniae D39 4442500 YP_815573.1 CDS SPD_0093 NC_008533.1 93718 94782 R equivalent gene in S.pneumoniae TIGR4 = SP0097; equivalent gene in S.pneumoniae R6 = spr0086; hypothetical protein complement(93718..94782) Streptococcus pneumoniae D39 4442117 YP_815575.1 CDS SPD_0094 NC_008533.1 94845 95756 R equivalent gene in S.pneumoniae TIGR4 = SP0098; equivalent gene in S.pneumoniae R6 = spr0087; hypothetical protein complement(94845..95756) Streptococcus pneumoniae D39 4442881 YP_815578.1 CDS SPD_0095 NC_008533.1 95749 96342 R equivalent gene in S.pneumoniae TIGR4 = SP0099; equivalent gene in S.pneumoniae R6 = spr0088; hypothetical protein complement(95749..96342) Streptococcus pneumoniae D39 4442963 YP_815579.1 CDS SPD_0096 NC_008533.1 96329 96655 R equivalent gene in S.pneumoniae TIGR4 = SP0100; equivalent gene in S.pneumoniae R6 = spr0089; identified by match to protein family HMM PF03551; hypothetical protein complement(96329..96655) Streptococcus pneumoniae D39 4442264 YP_815581.1 CDS SPD_0097 NC_008533.1 96794 97960 R equivalent gene in S.pneumoniae TIGR4 = SP0101; equivalent gene in S.pneumoniae R6 = spr0090; identified by match to protein family HMM PF07690; transporter complement(96794..97960) Streptococcus pneumoniae D39 4442733 YP_815584.1 CDS SPD_0098 NC_008533.1 98018 99175 D equivalent gene in S.pneumoniae TIGR4 = SP0102; equivalent gene in S.pneumoniae R6 = spr0091; identified by match to protein family HMM PF00535; glycosyl transferase family protein 98018..99175 Streptococcus pneumoniae D39 4441359 YP_815587.1 CDS capD NC_008533.1 99217 101067 D equivalent gene in S.pneumoniae TIGR4 = SP0103; equivalent gene in S.pneumoniae R6 = spr0092; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; capsular polysaccharide biosynthesis protein 99217..101067 Streptococcus pneumoniae D39 4441836 YP_815590.1 CDS SPD_0101 NC_008533.1 101463 102095 R equivalent gene in S.pneumoniae TIGR4 = SP0104; equivalent gene in S.pneumoniae R6 = spr0093; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; hydrolase complement(101463..102095) Streptococcus pneumoniae D39 4441555 YP_815591.1 CDS sdhA NC_008533.1 102117 102989 R equivalent gene in S.pneumoniae TIGR4 = SP0105; equivalent gene in S.pneumoniae R6 = spr0094; identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; L-serine dehydratase, iron-sulfur-dependent subunit alpha complement(102117..102989) Streptococcus pneumoniae D39 4443076 YP_815593.1 CDS sdhB NC_008533.1 102998 103669 R equivalent gene in S.pneumoniae TIGR4 = SP0106; equivalent gene in S.pneumoniae R6 = spr0095; identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; L-serine dehydratase, iron-sulfur-dependent subunit beta complement(102998..103669) Streptococcus pneumoniae D39 4442212 YP_815595.1 CDS SPD_0104 NC_008533.1 103911 104414 D equivalent gene in S.pneumoniae TIGR4 = SP0107; equivalent gene in S.pneumoniae R6 = spr0096; identified by match to protein family HMM PF01476; LysM domain-containing protein 103911..104414 Streptococcus pneumoniae D39 4442321 YP_815596.1 CDS SPD_0105 NC_008533.1 104537 104785 R equivalent gene in S.pneumoniae TIGR4 = SP0114; equivalent gene in S.pneumoniae R6 = spr0097; hypothetical protein complement(104537..104785) Streptococcus pneumoniae D39 4441541 YP_815600.1 CDS SPD_0106 NC_008533.1 105242 105490 D equivalent gene in S.pneumoniae R6 = spr0098; identified by match to protein family HMM TIGR01653; bacteriocin 105242..105490 Streptococcus pneumoniae D39 4441855 YP_815603.1 CDS SPD_0107 NC_008533.1 105545 107653 D equivalent gene in S.pneumoniae TIGR4 = SP0110; equivalent gene in S.pneumoniae R6 = spr0099; identified by match to protein family HMM TIGR01654; membrnae protein 105545..107653 Streptococcus pneumoniae D39 4443033 YP_815605.1 CDS SPD_0108 NC_008533.1 107650 108291 D equivalent gene in S.pneumoniae TIGR4 = SP0111; equivalent gene in S.pneumoniae R6 = spr0100; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 107650..108291 Streptococcus pneumoniae D39 4442006 YP_815607.1 CDS SPD_0109 NC_008533.1 108497 109303 D equivalent gene in S.pneumoniae TIGR4 = SP0112; equivalent gene in S.pneumoniae R6 = spr0101; identified by match to protein family HMM PF00497; amino acid ABC transporter periplasmic amino acid-binding protein 108497..109303 Streptococcus pneumoniae D39 4441134 YP_815608.1 CDS argG NC_008533.1 109320 110516 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 109320..110516 Streptococcus pneumoniae D39 4441249 YP_815610.1 CDS argH NC_008533.1 110545 111936 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 110545..111936 Streptococcus pneumoniae D39 4442024 YP_815612.1 CDS SPD_0112 NC_008533.1 112225 113088 R equivalent gene in S.pneumoniae TIGR4 = SP0108; equivalent gene in S.pneumoniae R6 = spr0104; identified by match to protein family HMM PF01381; hypothetical protein complement(112225..113088) Streptococcus pneumoniae D39 4442657 YP_815614.1 CDS SPD_0114 NC_008533.1 115766 116233 D equivalent gene in S.pneumoniae R6 = spr0107; hypothetical protein 115766..116233 Streptococcus pneumoniae D39 4442817 YP_815617.1 CDS SPD_0115 NC_008533.1 116230 117582 D equivalent gene in S.pneumoniae R6 = spr0108; hypothetical protein 116230..117582 Streptococcus pneumoniae D39 4443072 YP_815619.1 CDS SPD_0116 NC_008533.1 117728 118108 D equivalent gene in S.pneumoniae TIGR4 = SP0115; equivalent gene in S.pneumoniae R6 = spr0109; hypothetical protein 117728..118108 Streptococcus pneumoniae D39 4441389 YP_815621.1 CDS SPD_0117 NC_008533.1 119688 120059 D equivalent gene in S.pneumoniae R6 = spr0111; hypothetical protein 119688..120059 Streptococcus pneumoniae D39 4442801 YP_815623.1 CDS SPD_0118 NC_008533.1 120653 120778 D hypothetical protein 120653..120778 Streptococcus pneumoniae D39 4442258 YP_815626.1 CDS SPD_0119 NC_008533.1 121084 122142 D equivalent gene in S.pneumoniae R6 = spr0113; hypothetical protein 121084..122142 Streptococcus pneumoniae D39 4442650 YP_815628.1 CDS SPD_0120 NC_008533.1 122456 123433 D equivalent gene in S.pneumoniae R6 = spr0114; hypothetical protein 122456..123433 Streptococcus pneumoniae D39 4442781 YP_815630.1 CDS SPD_0121 NC_008533.1 123810 124184 D equivalent gene in S.pneumoniae R6 = spr0115; hypothetical protein 123810..124184 Streptococcus pneumoniae D39 4441261 YP_815632.1 CDS SPD_0122 NC_008533.1 124392 125294 D equivalent gene in S.pneumoniae R6 = spr0117; hypothetical protein 124392..125294 Streptococcus pneumoniae D39 4441292 YP_815634.1 CDS SPD_0123 NC_008533.1 125350 125703 D equivalent gene in S.pneumoniae R6 = spr0118; hypothetical protein 125350..125703 Streptococcus pneumoniae D39 4442843 YP_815636.1 CDS SPD_0124 NC_008533.1 125670 126428 D equivalent gene in S.pneumoniae R6 = spr0119; hypothetical protein 125670..126428 Streptococcus pneumoniae D39 4442837 YP_815639.1 CDS SPD_0125 NC_008533.1 127557 127802 D equivalent gene in S.pneumoniae TIGR4 = SP0116; equivalent gene in S.pneumoniae R6 = spr0120; hypothetical protein 127557..127802 Streptococcus pneumoniae D39 4441999 YP_815641.1 CDS pspA NC_008533.1 128356 130215 D equivalent gene in S.pneumoniae R6 = spr0121; identified by match to protein family HMM PF01473; surface protein A 128356..130215 Streptococcus pneumoniae D39 4441373 YP_815643.1 CDS mnmA NC_008533.1 130616 131737 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 130616..131737 Streptococcus pneumoniae D39 4442268 YP_815645.1 CDS SPD_0128 NC_008533.1 131878 132333 D equivalent gene in S.pneumoniae TIGR4 = SP0119; equivalent gene in S.pneumoniae R6 = spr0123; identified by match to protein family HMM PF00293; MutT/nudix family protein 131878..132333 Streptococcus pneumoniae D39 4442563 YP_815647.1 CDS gidA NC_008533.1 132343 134256 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 132343..134256 Streptococcus pneumoniae D39 4441194 YP_815649.1 CDS SPD_0130 NC_008533.1 134636 136315 R equivalent gene in S.pneumoniae TIGR4 = SP0121; equivalent gene in S.pneumoniae R6 = spr0125; identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649; metallo-beta-lactamase domain-containing protein complement(134636..136315) Streptococcus pneumoniae D39 4442834 YP_815651.1 CDS SPD_0131 NC_008533.1 136317 136550 R equivalent gene in S.pneumoniae TIGR4 = SP0122; equivalent gene in S.pneumoniae R6 = spr0126; identified by match to protein family HMM PF07288; hypothetical protein complement(136317..136550) Streptococcus pneumoniae D39 4442882 YP_815652.1 CDS SPD_0132 NC_008533.1 137368 137520 R equivalent gene in S.pneumoniae TIGR4 = SP0124; equivalent gene in S.pneumoniae R6 = spr0127; identified by match to protein family HMM TIGR01847; hypothetical protein complement(137368..137520) Streptococcus pneumoniae D39 4441224 YP_815653.1 CDS SPD_0133 NC_008533.1 137522 137707 R equivalent gene in S.pneumoniae TIGR4 = SP0125; equivalent gene in S.pneumoniae R6 = spr0128; hypothetical protein complement(137522..137707) Streptococcus pneumoniae D39 4442244 YP_815654.1 CDS SPD_0134 NC_008533.1 137885 138568 D equivalent gene in S.pneumoniae TIGR4 = SP0127; equivalent gene in S.pneumoniae R6 = spr0129; identified by match to protein family HMM PF00814; hypothetical protein 137885..138568 Streptococcus pneumoniae D39 4442229 YP_815655.1 CDS rimI NC_008533.1 138565 139002 D equivalent gene in S.pneumoniae TIGR4 = SP0128; equivalent gene in S.pneumoniae R6 = spr0130; identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575; ribosomal-protein-alanine acetyltransferase 138565..139002 Streptococcus pneumoniae D39 4441132 YP_815656.1 CDS SPD_0136 NC_008533.1 138992 140002 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 138992..140002 Streptococcus pneumoniae D39 4441951 YP_815657.1 CDS SPD_0138 NC_008533.1 142604 143809 D equivalent gene in S.pneumoniae TIGR4 = SP0133; equivalent gene in S.pneumoniae R6 = spr0135; identified by match to protein family HMM PF00534; glycoside hydrolase family protein 142604..143809 Streptococcus pneumoniae D39 4442811 YP_815658.1 CDS SPD_0139 NC_008533.1 143802 144755 D equivalent gene in S.pneumoniae TIGR4 = SP0136; equivalent gene in S.pneumoniae R6 = spr0136; identified by match to protein family HMM PF00535; glycosyl transferase family protein 143802..144755 Streptococcus pneumoniae D39 4442091 YP_815659.1 CDS SPD_0140 NC_008533.1 144765 146381 D equivalent gene in S.pneumoniae TIGR4 = SP0137; equivalent gene in S.pneumoniae R6 = spr0137; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 144765..146381 Streptococcus pneumoniae D39 4441371 YP_815660.1 CDS SPD_0141 NC_008533.1 146691 147158 D equivalent gene in S.pneumoniae TIGR4 = SP0138; hypothetical protein 146691..147158 Streptococcus pneumoniae D39 4442487 YP_815661.1 CDS SPD_0142 NC_008533.1 147164 147919 D equivalent gene in S.pneumoniae TIGR4 = SP0139; equivalent gene in S.pneumoniae R6 = spr0138; identified by match to protein family HMM PF02585; hypothetical protein 147164..147919 Streptococcus pneumoniae D39 4442942 YP_815662.1 CDS SPD_0143 NC_008533.1 147932 149104 D equivalent gene in S.pneumoniae R6 = spr0139; identified by match to protein family HMM PF00984; match to protein family HMM PF03721; UDP-glucose 6-dehydrogenase 147932..149104 Streptococcus pneumoniae D39 4441082 YP_815663.1 CDS SPD_0144 NC_008533.1 149499 150362 D equivalent gene in S.pneumoniae TIGR4 = SP0141; equivalent gene in S.pneumoniae R6 = spr0140; identified by match to protein family HMM TIGR01716; transcriptional regulator 149499..150362 Streptococcus pneumoniae D39 4442395 YP_815664.1 CDS SPD_0145 NC_008533.1 150653 150886 D equivalent gene in S.pneumoniae TIGR4 = SP0142; equivalent gene in S.pneumoniae R6 = spr0141; hypothetical protein 150653..150886 Streptococcus pneumoniae D39 4442683 YP_815665.1 CDS SPD_0146 NC_008533.1 150908 151585 D equivalent gene in S.pneumoniae TIGR4 = SP0143; equivalent gene in S.pneumoniae R6 = spr0142; identified by match to protein family HMM PF02517; CAAX amino terminal protease family protein 150908..151585 Streptococcus pneumoniae D39 4442954 YP_815666.1 CDS SPD_0147 NC_008533.1 151597 152262 D equivalent gene in S.pneumoniae TIGR4 = SP0144; equivalent gene in S.pneumoniae R6 = spr0143; identified by match to protein family HMM PF02517; CAAX amino terminal protease family protein 151597..152262 Streptococcus pneumoniae D39 4441117 YP_815667.1 CDS SPD_0148 NC_008533.1 152334 153560 D equivalent gene in S.pneumoniae TIGR4 = SP0145; equivalent gene in S.pneumoniae R6 = spr0144; identified by match to protein family HMM PF07690; transporter major facilitator family protein 152334..153560 Streptococcus pneumoniae D39 4441949 YP_815668.1 CDS SPD_0149 NC_008533.1 153893 154366 D equivalent gene in S.pneumoniae TIGR4 = SP0146; equivalent gene in S.pneumoniae R6 = spr0145; identified by match to protein family HMM PF03591; hypothetical protein 153893..154366 Streptococcus pneumoniae D39 4441271 YP_815669.1 CDS SPD_0150 NC_008533.1 154470 155300 D equivalent gene in S.pneumoniae TIGR4 = SP0148; equivalent gene in S.pneumoniae R6 = spr0146; identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein 154470..155300 Streptococcus pneumoniae D39 4441909 YP_815670.1 CDS SPD_0151 NC_008533.1 155454 156308 D equivalent gene in S.pneumoniae TIGR4 = SP0149; equivalent gene in S.pneumoniae R6 = spr0147; identified by match to protein family HMM PF03180; lipoprotein 155454..156308 Streptococcus pneumoniae D39 4442566 YP_815671.1 CDS SPD_0152 NC_008533.1 156408 157781 D equivalent gene in S.pneumoniae TIGR4 = SP0150; equivalent gene in S.pneumoniae R6 = spr0148; identified by match to protein family HMM PF01546; match to protein family HMM PF07687; hypothetical protein 156408..157781 Streptococcus pneumoniae D39 4441623 YP_815672.1 CDS SPD_0153 NC_008533.1 157774 158835 D equivalent gene in S.pneumoniae TIGR4 = SP0151; equivalent gene in S.pneumoniae R6 = spr0149; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 157774..158835 Streptococcus pneumoniae D39 4441119 YP_815673.1 CDS SPD_0154 NC_008533.1 158837 159529 D equivalent gene in S.pneumoniae TIGR4 = SP0152; equivalent gene in S.pneumoniae R6 = spr0150; identified by match to protein family HMM PF00528; ABC transporter permease 158837..159529 Streptococcus pneumoniae D39 4441883 YP_815674.1 CDS SPD_0155 NC_008533.1 159559 160128 R equivalent gene in S.pneumoniae TIGR4 = SP0153; equivalent gene in S.pneumoniae R6 = spr0151; identified by match to protein family HMM TIGR02185; hypothetical protein complement(159559..160128) Streptococcus pneumoniae D39 4442311 YP_815675.1 CDS SPD_0156 NC_008533.1 160263 160877 D equivalent gene in S.pneumoniae TIGR4 = SP0154; equivalent gene in S.pneumoniae R6 = spr0152; identified by match to protein family HMM PF04854; hypothetical protein 160263..160877 Streptococcus pneumoniae D39 4441248 YP_815676.1 CDS SPD_0157 NC_008533.1 160879 162525 D equivalent gene in S.pneumoniae TIGR4 = SP0155; equivalent gene in S.pneumoniae R6 = spr0153; identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580; sensor histidine kinase 160879..162525 Streptococcus pneumoniae D39 4442660 YP_815677.1 CDS SPD_0158 NC_008533.1 162537 163823 D equivalent gene in S.pneumoniae TIGR4 = SP0156; equivalent gene in S.pneumoniae R6 = spr0154; identified by match to protein family HMM PF00072; match to protein family HMM PF00165; DNA-binding response regulator 162537..163823 Streptococcus pneumoniae D39 4443064 YP_815678.1 CDS SPD_0159 NC_008533.1 163875 164408 D equivalent gene in S.pneumoniae TIGR4 = SP0157; equivalent gene in S.pneumoniae R6 = spr0155; hypothetical protein 163875..164408 Streptococcus pneumoniae D39 4441770 YP_815679.1 CDS SPD_0160 NC_008533.1 164486 164956 D has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 164486..164956 Streptococcus pneumoniae D39 4442534 YP_815680.1 CDS SPD_0161 NC_008533.1 165249 166511 R equivalent gene in S.pneumoniae TIGR4 = SP0159; equivalent gene in S.pneumoniae R6 = spr0157; hypothetical protein complement(165249..166511) Streptococcus pneumoniae D39 4442074 YP_815681.1 CDS SPD_0162 NC_008533.1 166821 167279 R equivalent gene in S.pneumoniae TIGR4 = SP0160; equivalent gene in S.pneumoniae R6 = spr0158; hypothetical protein complement(166821..167279) Streptococcus pneumoniae D39 4441098 YP_815682.1 CDS SPD_0163 NC_008533.1 167276 167716 R equivalent gene in S.pneumoniae TIGR4 = SP0161; equivalent gene in S.pneumoniae R6 = spr0159; identified by match to protein family HMM PF04397; hypothetical protein complement(167276..167716) Streptococcus pneumoniae D39 4442328 YP_815683.1 CDS SPD_0164 NC_008533.1 167832 168011 D equivalent gene in S.pneumoniae TIGR4 = SP0172; hypothetical protein 167832..168011 Streptococcus pneumoniae D39 4441201 YP_815684.1 CDS mutL NC_008533.1 168072 170021 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 168072..170021 Streptococcus pneumoniae D39 4441603 YP_815685.1 CDS ribH NC_008533.1 170346 170813 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(170346..170813) Streptococcus pneumoniae D39 4442376 YP_815686.1 CDS ribB NC_008533.1 170814 172019 R equivalent gene in S.pneumoniae TIGR4 = SP0176; equivalent gene in S.pneumoniae R6 = spr0162; identified by match to protein family HMM PF00925; match to protein family HMM PF00926; match to protein family HMM TIGR00505; match to protein family HMM TIGR00506; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(170814..172019) Streptococcus pneumoniae D39 4441629 YP_815687.1 CDS ribE NC_008533.1 172039 172674 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(172039..172674) Streptococcus pneumoniae D39 4442192 YP_815688.1 CDS ribD NC_008533.1 172659 173759 R equivalent gene in S.pneumoniae TIGR4 = SP0178; equivalent gene in S.pneumoniae R6 = spr0164; identified by match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326; riboflavin biosynthesis protein RibD complement(172659..173759) Streptococcus pneumoniae D39 4441673 YP_815689.1 CDS ruvA NC_008533.1 174163 174756 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 174163..174756 Streptococcus pneumoniae D39 4442652 YP_815690.1 CDS tag NC_008533.1 174766 175329 D equivalent gene in S.pneumoniae TIGR4 = SP0180; equivalent gene in S.pneumoniae R6 = spr0166; identified by match to protein family HMM PF03352; DNA-3-methyladenine glycosylase I 174766..175329 Streptococcus pneumoniae D39 4442938 YP_815691.1 CDS SPD_0172 NC_008533.1 175326 176003 D equivalent gene in S.pneumoniae TIGR4 = SP0181; equivalent gene in S.pneumoniae R6 = spr0167; identified by match to protein family HMM PF02517; hypothetical protein 175326..176003 Streptococcus pneumoniae D39 4441445 YP_815692.1 CDS SPD_0173 NC_008533.1 176158 177189 R equivalent gene in S.pneumoniae TIGR4 = SP0182; equivalent gene in S.pneumoniae R6 = spr0168; identified by match to protein family HMM PF02016; MccC family protein complement(176158..177189) Streptococcus pneumoniae D39 4443067 YP_815693.1 CDS SPD_0174 NC_008533.1 177444 178148 R equivalent gene in S.pneumoniae TIGR4 = SP0184; equivalent gene in S.pneumoniae R6 = spr0169; identified by match to protein family HMM PF06570; hypothetical protein complement(177444..178148) Streptococcus pneumoniae D39 4442070 YP_815694.1 CDS SPD_0175 NC_008533.1 178139 179083 R equivalent gene in S.pneumoniae TIGR4 = SP0185; equivalent gene in S.pneumoniae R6 = spr0170; identified by match to protein family HMM PF01544; magnesium transporter CorA family protein complement(178139..179083) Streptococcus pneumoniae D39 4442860 YP_815695.1 CDS uvrA NC_008533.1 179215 182046 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 179215..182046 Streptococcus pneumoniae D39 4441897 YP_815696.1 CDS SPD_0177 NC_008533.1 182039 183100 D equivalent gene in S.pneumoniae TIGR4 = SP0187; equivalent gene in S.pneumoniae R6 = spr0172; identified by match to protein family HMM PF00557; peptidase M24 family protein 182039..183100 Streptococcus pneumoniae D39 4442225 YP_815697.1 CDS spxA NC_008533.1 183232 183630 D the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 183232..183630 Streptococcus pneumoniae D39 4441659 YP_815698.1 CDS SPD_0179 NC_008533.1 183696 184265 D equivalent gene in S.pneumoniae TIGR4 = SP0191; equivalent gene in S.pneumoniae R6 = spr0174; hypothetical protein 183696..184265 Streptococcus pneumoniae D39 4442473 YP_815699.1 CDS SPD_0180 NC_008533.1 184352 184618 D equivalent gene in S.pneumoniae TIGR4 = SP0192; equivalent gene in S.pneumoniae R6 = spr0175; identified by match to protein family HMM PF06135; hypothetical protein 184352..184618 Streptococcus pneumoniae D39 4442962 YP_815700.1 CDS SPD_0181 NC_008533.1 184622 185041 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 184622..185041 Streptococcus pneumoniae D39 4442867 YP_815701.1 CDS SPD_0182 NC_008533.1 185057 185362 D equivalent gene in S.pneumoniae TIGR4 = SP0194; equivalent gene in S.pneumoniae R6 = spr0177; identified by match to protein family HMM PF06949; hypothetical protein 185057..185362 Streptococcus pneumoniae D39 4441357 YP_815702.1 CDS folC NC_008533.1 185813 187069 D equivalent gene in S.pneumoniae TIGR4 = SP0197; equivalent gene in S.pneumoniae R6 = spr0178; identified by match to protein family HMM PF02875; match to protein family HMM TIGR01499; folylpolyglutamate synthase 185813..187069 Streptococcus pneumoniae D39 4443024 YP_815703.1 CDS SPD_0184 NC_008533.1 187153 187584 D equivalent gene in S.pneumoniae R6 = spr0179; hypothetical protein 187153..187584 Streptococcus pneumoniae D39 4443005 YP_815704.1 CDS SPD_0185 NC_008533.1 187730 189262 D equivalent gene in S.pneumoniae TIGR4 = SP0199; equivalent gene in S.pneumoniae R6 = spr0180; identified by match to protein family HMM PF00614; cardiolipin synthetase 187730..189262 Streptococcus pneumoniae D39 4441354 YP_815705.1 CDS SPD_0186 NC_008533.1 189520 191058 D equivalent gene in S.pneumoniae TIGR4 = SP0200; equivalent gene in S.pneumoniae R6 = spr0182; competence-induced protein Ccs4 189520..191058 Streptococcus pneumoniae D39 4441212 YP_815706.1 CDS nrdD NC_008533.1 191178 193385 D Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 191178..193385 Streptococcus pneumoniae D39 4442072 YP_815707.1 CDS SPD_0188 NC_008533.1 193397 193537 D equivalent gene in S.pneumoniae TIGR4 = SP0203; hypothetical protein 193397..193537 Streptococcus pneumoniae D39 4441095 YP_815708.1 CDS SPD_0189 NC_008533.1 193581 194087 D equivalent gene in S.pneumoniae TIGR4 = SP0204; equivalent gene in S.pneumoniae R6 = spr0184; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 193581..194087 Streptococcus pneumoniae D39 4441790 YP_815709.1 CDS nrdG NC_008533.1 194080 194670 D equivalent gene in S.pneumoniae TIGR4 = SP0205; equivalent gene in S.pneumoniae R6 = spr0185; identified by match to protein family HMM PF04055; match to protein family HMM TIGR02491; anaerobic ribonucleoside-triphosphate reductase activating protein 194080..194670 Streptococcus pneumoniae D39 4442564 YP_815710.1 CDS SPD_0191 NC_008533.1 194667 195284 D equivalent gene in S.pneumoniae TIGR4 = SP0207; equivalent gene in S.pneumoniae R6 = spr0186; identified by match to protein family HMM PF00485; hypothetical protein 194667..195284 Streptococcus pneumoniae D39 4442009 YP_815711.1 CDS rpsJ NC_008533.1 195551 195859 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 195551..195859 Streptococcus pneumoniae D39 4442442 YP_815712.1 CDS rplC NC_008533.1 196076 196702 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 196076..196702 Streptococcus pneumoniae D39 4442313 YP_815713.1 CDS rplD NC_008533.1 196727 197350 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 196727..197350 Streptococcus pneumoniae D39 4441166 YP_815714.1 CDS rplW NC_008533.1 197350 197646 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 197350..197646 Streptococcus pneumoniae D39 4441121 YP_815715.1 CDS rplB NC_008533.1 197664 198497 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 197664..198497 Streptococcus pneumoniae D39 4441318 YP_815716.1 CDS rpsS NC_008533.1 198601 198882 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 198601..198882 Streptococcus pneumoniae D39 4441637 YP_815717.1 CDS rplV NC_008533.1 198894 199238 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 198894..199238 Streptococcus pneumoniae D39 4441833 YP_815718.1 CDS rpsC NC_008533.1 199251 199904 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 199251..199904 Streptococcus pneumoniae D39 4442472 YP_815719.1 CDS rplP NC_008533.1 199908 200321 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 199908..200321 Streptococcus pneumoniae D39 4442707 YP_815720.1 CDS rpmC NC_008533.1 200331 200537 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 200331..200537 Streptococcus pneumoniae D39 4442014 YP_815721.1 CDS rpsQ NC_008533.1 200562 200822 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 200562..200822 Streptococcus pneumoniae D39 4441547 YP_815722.1 CDS rplN NC_008533.1 200848 201216 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 200848..201216 Streptococcus pneumoniae D39 4441971 YP_815723.1 CDS rplX NC_008533.1 201294 201599 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 201294..201599 Streptococcus pneumoniae D39 4442759 YP_815724.1 CDS rplE NC_008533.1 201623 202165 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 201623..202165 Streptococcus pneumoniae D39 4441281 YP_815725.1 CDS rpsN NC_008533.1 202183 202452 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 202183..202452 Streptococcus pneumoniae D39 4442794 YP_815726.1 CDS rpsH NC_008533.1 202737 203135 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 202737..203135 Streptococcus pneumoniae D39 4441447 YP_815727.1 CDS rplF NC_008533.1 203327 203863 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 203327..203863 Streptococcus pneumoniae D39 4442016 YP_815728.1 CDS rplR NC_008533.1 203947 204303 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 203947..204303 Streptococcus pneumoniae D39 4441109 YP_815729.1 CDS rpsE NC_008533.1 204321 204815 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 204321..204815 Streptococcus pneumoniae D39 4441305 YP_815730.1 CDS rpmD NC_008533.1 204829 205011 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 204829..205011 Streptococcus pneumoniae D39 4442286 YP_815731.1 CDS rplO NC_008533.1 205156 205596 D late assembly protein; 50S ribosomal protein L15 205156..205596 Streptococcus pneumoniae D39 4441621 YP_815732.1 CDS secY NC_008533.1 205609 206919 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 205609..206919 Streptococcus pneumoniae D39 4442064 YP_815733.1 CDS adk NC_008533.1 207070 207708 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 207070..207708 Streptococcus pneumoniae D39 4441374 YP_815734.1 CDS infA NC_008533.1 207825 208043 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 207825..208043 Streptococcus pneumoniae D39 4441889 YP_815735.1 CDS rpsM NC_008533.1 208202 208567 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 208202..208567 Streptococcus pneumoniae D39 4442756 YP_815736.1 CDS rpsK NC_008533.1 208585 208968 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 208585..208968 Streptococcus pneumoniae D39 4441288 YP_815737.1 CDS rpoA NC_008533.1 209011 209946 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 209011..209946 Streptococcus pneumoniae D39 4442582 YP_815738.1 CDS rplQ NC_008533.1 209958 210344 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 209958..210344 Streptococcus pneumoniae D39 4441294 YP_815739.1 CDS SPD_0220 NC_008533.1 210609 210875 D ACT domain-containing protein; hypothetical protein 210609..210875 Streptococcus pneumoniae D39 4443048 YP_815740.1 CDS SPD_0222 NC_008533.1 212467 213159 D equivalent gene in S.pneumoniae TIGR4 = SP0240; equivalent gene in S.pneumoniae R6 = spr0219; identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 212467..213159 Streptococcus pneumoniae D39 4443016 YP_815741.1 CDS SPD_0223 NC_008533.1 213262 214254 R equivalent gene in S.pneumoniae R6 = spr0220; identified by match to protein family HMM PF00528; iron(III) ABC transporter permease complement(213262..214254) Streptococcus pneumoniae D39 4442708 YP_815742.1 CDS SPD_0224 NC_008533.1 214281 214907 R equivalent gene in S.pneumoniae R6 = spr0221; iron(III) ABC transporter permease complement(214281..214907) Streptococcus pneumoniae D39 4442315 YP_815743.1 CDS SPD_0225 NC_008533.1 214897 215988 R equivalent gene in S.pneumoniae TIGR4 = SP0242; equivalent gene in S.pneumoniae R6 = spr0222; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(214897..215988) Streptococcus pneumoniae D39 4442171 YP_815744.1 CDS SPD_0226 NC_008533.1 216001 216369 R equivalent gene in S.pneumoniae TIGR4 = SP0243; equivalent gene in S.pneumoniae R6 = spr0223; iron ABC transporter iron-binding protein complement(216001..216369) Streptococcus pneumoniae D39 4442863 YP_815745.1 CDS SPD_0227 NC_008533.1 216514 216708 R equivalent gene in S.pneumoniae TIGR4 = SP0243; equivalent gene in S.pneumoniae R6 = spr0224; iron(III) ABC transporter iron-binding protein complement(216514..216708) Streptococcus pneumoniae D39 4442926 YP_815746.1 CDS SPD_0228 NC_008533.1 217340 217537 R equivalent gene in S.pneumoniae R6 = spr0225; identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(217340..217537) Streptococcus pneumoniae D39 4442506 YP_815747.1 CDS SPD_0229 NC_008533.1 217612 218388 R equivalent gene in S.pneumoniae TIGR4 = SP0245; equivalent gene in S.pneumoniae R6 = spr0226; identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; glycyl-radical enzyme activating protein family protein complement(217612..218388) Streptococcus pneumoniae D39 4441823 YP_815748.1 CDS SPD_0230 NC_008533.1 218510 219256 D equivalent gene in S.pneumoniae TIGR4 = SP0246; equivalent gene in S.pneumoniae R6 = spr0227; identified by match to protein family HMM PF00455; match to protein family HMM PF08220; DeoR family transcriptional regulator 218510..219256 Streptococcus pneumoniae D39 4442581 YP_815749.1 CDS SPD_0231 NC_008533.1 219269 220249 D equivalent gene in S.pneumoniae TIGR4 = SP0247; equivalent gene in S.pneumoniae R6 = spr0228; identified by match to protein family HMM PF04198; transcriptional activator 219269..220249 Streptococcus pneumoniae D39 4441800 YP_815750.1 CDS SPD_0232 NC_008533.1 220444 220764 D equivalent gene in S.pneumoniae TIGR4 = SP0248; equivalent gene in S.pneumoniae R6 = spr0229; identified by match to protein family HMM PF02255; PTS system transporter subunit IIA 220444..220764 Streptococcus pneumoniae D39 4441366 YP_815751.1 CDS SPD_0233 NC_008533.1 220810 221118 D equivalent gene in S.pneumoniae TIGR4 = SP0249; equivalent gene in S.pneumoniae R6 = spr0230; identified by match to protein family HMM PF02302; PTS system transporter subunit IIB 220810..221118 Streptococcus pneumoniae D39 4441183 YP_815752.1 CDS SPD_0234 NC_008533.1 221135 222433 D equivalent gene in S.pneumoniae TIGR4 = SP0250; equivalent gene in S.pneumoniae R6 = spr0231; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system transporter subunit IIC 221135..222433 Streptococcus pneumoniae D39 4441370 YP_815753.1 CDS pfl NC_008533.1 222584 225022 D equivalent gene in S.pneumoniae TIGR4 = SP0251; equivalent gene in S.pneumoniae R6 = spr0232; identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; pyruvate formate-lyase 222584..225022 Streptococcus pneumoniae D39 4442887 YP_815754.1 CDS talC NC_008533.1 225041 225709 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 225041..225709 Streptococcus pneumoniae D39 4442052 YP_815755.1 CDS gldA NC_008533.1 225727 226815 D forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 225727..226815 Streptococcus pneumoniae D39 4442775 YP_815756.1 CDS leuS NC_008533.1 227270 229771 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 227270..229771 Streptococcus pneumoniae D39 4441803 YP_815757.1 CDS SPD_0239 NC_008533.1 229965 230660 D equivalent gene in S.pneumoniae TIGR4 = SP0255; equivalent gene in S.pneumoniae R6 = spr0236; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 229965..230660 Streptococcus pneumoniae D39 4441390 YP_815758.1 CDS SPD_0240 NC_008533.1 230672 231088 D equivalent gene in S.pneumoniae R6 = spr0237; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 230672..231088 Streptococcus pneumoniae D39 4441839 YP_815759.1 CDS ruvB NC_008533.1 232129 233127 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 232129..233127 Streptococcus pneumoniae D39 4442853 YP_815760.1 CDS SPD_0242 NC_008533.1 233108 233680 D equivalent gene in S.pneumoniae TIGR4 = SP0260; equivalent gene in S.pneumoniae R6 = spr0239; identified by match to protein family HMM PF06042; hypothetical protein 233108..233680 Streptococcus pneumoniae D39 4443043 YP_815761.1 CDS uppS NC_008533.1 233911 234669 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 233911..234669 Streptococcus pneumoniae D39 4442907 YP_815762.1 CDS cdsA NC_008533.1 234678 235481 D equivalent gene in S.pneumoniae TIGR4 = SP0262; equivalent gene in S.pneumoniae R6 = spr0241; identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 234678..235481 Streptococcus pneumoniae D39 4441416 YP_815763.1 CDS eep NC_008533.1 235503 236762 D equivalent gene in S.pneumoniae TIGR4 = SP0263; equivalent gene in S.pneumoniae R6 = spr0242; identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054; zinc metalloprotease Eep 235503..236762 Streptococcus pneumoniae D39 4441442 YP_815764.1 CDS proS NC_008533.1 236775 238628 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 236775..238628 Streptococcus pneumoniae D39 4441404 YP_815765.1 CDS SPD_0247 NC_008533.1 238728 240107 D equivalent gene in S.pneumoniae TIGR4 = SP0265; equivalent gene in S.pneumoniae R6 = spr0244; identified by match to protein family HMM PF00232; glycosyl hydrolase family protein 238728..240107 Streptococcus pneumoniae D39 4441054 YP_815766.1 CDS glmS NC_008533.1 240299 242107 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 240299..242107 Streptococcus pneumoniae D39 4441452 YP_815767.1 CDS SPD_0249 NC_008533.1 242226 243275 D equivalent gene in S.pneumoniae TIGR4 = SP0267; equivalent gene in S.pneumoniae R6 = spr0246; identified by match to protein family HMM PF00296; hypothetical protein 242226..243275 Streptococcus pneumoniae D39 4441182 YP_815768.1 CDS SPD_0250 NC_008533.1 243375 247145 R equivalent gene in S.pneumoniae TIGR4 = SP0268; equivalent gene in S.pneumoniae R6 = spr0247; identified by match to protein family HMM PF00128; match to protein family HMM PF00746; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; match to protein family HMM TIGR02102; pullulanase, extracellular complement(243375..247145) Streptococcus pneumoniae D39 4442469 YP_815769.1 CDS rpsL NC_008533.1 247562 247975 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 247562..247975 Streptococcus pneumoniae D39 4442792 YP_815770.1 CDS rpsG NC_008533.1 247995 248465 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 247995..248465 Streptococcus pneumoniae D39 4442066 YP_815771.1 CDS fusA NC_008533.1 248890 250971 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 248890..250971 Streptococcus pneumoniae D39 4442302 YP_815772.1 CDS polC NC_008533.1 251075 255466 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 251075..255466 Streptococcus pneumoniae D39 4441537 YP_815773.1 CDS SPD_0255 NC_008533.1 255568 255831 D equivalent gene in S.pneumoniae TIGR4 = SP0275; equivalent gene in S.pneumoniae R6 = spr0252; identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384; hypothetical protein 255568..255831 Streptococcus pneumoniae D39 4442129 YP_815774.1 CDS SPD_0256 NC_008533.1 255824 256102 D equivalent gene in S.pneumoniae TIGR4 = SP0276; equivalent gene in S.pneumoniae R6 = spr0253; identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; hypothetical protein 255824..256102 Streptococcus pneumoniae D39 4441641 YP_815775.1 CDS SPD_0257 NC_008533.1 256123 256275 D equivalent gene in S.pneumoniae TIGR4 = SP0277; hypothetical protein 256123..256275 Streptococcus pneumoniae D39 4442571 YP_815776.1 CDS pepS NC_008533.1 256297 257538 D equivalent gene in S.pneumoniae TIGR4 = SP0278; equivalent gene in S.pneumoniae R6 = spr0254; identified by match to protein family HMM PF02073; aminopeptidase PepS 256297..257538 Streptococcus pneumoniae D39 4443056 YP_815777.1 CDS SPD_0259 NC_008533.1 257548 257778 D equivalent gene in S.pneumoniae TIGR4 = SP0279; equivalent gene in S.pneumoniae R6 = spr0255; identified by match to protein family HMM PF04226; hypothetical protein 257548..257778 Streptococcus pneumoniae D39 4442952 YP_815778.1 CDS rsuA-1 NC_008533.1 258091 258813 D equivalent gene in S.pneumoniae TIGR4 = SP0280; equivalent gene in S.pneumoniae R6 = spr0256; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A 258091..258813 Streptococcus pneumoniae D39 4442757 YP_815779.1 CDS pepC NC_008533.1 259030 260364 D equivalent gene in S.pneumoniae TIGR4 = SP0281; equivalent gene in S.pneumoniae R6 = spr0258; identified by match to protein family HMM PF03051; aminopeptidase C 259030..260364 Streptococcus pneumoniae D39 4442061 YP_815780.1 CDS SPD_0262 NC_008533.1 260420 261331 R equivalent gene in S.pneumoniae TIGR4 = SP0282; equivalent gene in S.pneumoniae R6 = spr0259; identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system, mannose/fructose/sorbose family protein, IID component complement(260420..261331) Streptococcus pneumoniae D39 4442908 YP_815781.1 CDS manM NC_008533.1 261355 262158 R equivalent gene in S.pneumoniae TIGR4 = SP0283; equivalent gene in S.pneumoniae R6 = spr0260; identified by match to protein family HMM PF03609; PTS system mannose-specific transporter subunit IIC complement(261355..262158) Streptococcus pneumoniae D39 4441099 YP_815782.1 CDS manL NC_008533.1 262186 263175 R equivalent gene in S.pneumoniae TIGR4 = SP0284; equivalent gene in S.pneumoniae R6 = spr0261; identified by match to protein family HMM PF03610; match to protein family HMM PF03830; PTS system mannose-specific transporter subunit IIAB complement(262186..263175) Streptococcus pneumoniae D39 4441557 YP_815783.1 CDS SPD_0265 NC_008533.1 263408 264427 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(263408..264427) Streptococcus pneumoniae D39 4443070 YP_815784.1 CDS SPD_0266 NC_008533.1 264766 265578 R equivalent gene in S.pneumoniae TIGR4 = SP0286; equivalent gene in S.pneumoniae R6 = spr0263; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(264766..265578) Streptococcus pneumoniae D39 4442969 YP_815785.1 CDS SPD_0267 NC_008533.1 265768 267186 D equivalent gene in S.pneumoniae TIGR4 = SP0287; equivalent gene in S.pneumoniae R6 = spr0264; identified by match to protein family HMM PF00860; xanthine/uracil permease family protein 265768..267186 Streptococcus pneumoniae D39 4441298 YP_815786.1 CDS SPD_0268 NC_008533.1 267255 267947 D equivalent gene in S.pneumoniae TIGR4 = SP0288; equivalent gene in S.pneumoniae R6 = spr0265; identified by match to protein family HMM PF02517; hypothetical protein 267255..267947 Streptococcus pneumoniae D39 4442099 YP_815787.1 CDS folP NC_008533.1 268042 269016 D equivalent gene in S.pneumoniae TIGR4 = SP0289; equivalent gene in S.pneumoniae R6 = spr0266; identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase 268042..269016 Streptococcus pneumoniae D39 4443057 YP_815788.1 CDS SPD_0270 NC_008533.1 269018 270340 D equivalent gene in S.pneumoniae TIGR4 = SP0290; equivalent gene in S.pneumoniae R6 = spr0267; identified by match to protein family HMM PF02875; match to protein family HMM TIGR01499; folylpolyglutamate synthase 269018..270340 Streptococcus pneumoniae D39 4442295 YP_815789.1 CDS folE NC_008533.1 270321 270875 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 270321..270875 Streptococcus pneumoniae D39 4441347 YP_815790.1 CDS sulD NC_008533.1 270918 271730 D equivalent gene in S.pneumoniae TIGR4 = SP0292; equivalent gene in S.pneumoniae R6 = spr0269; identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498; bifunctional folate synthesis protein 270918..271730 Streptococcus pneumoniae D39 4441924 YP_815791.1 CDS SPD_0273 NC_008533.1 271775 272146 R equivalent gene in S.pneumoniae TIGR4 = SP0293; equivalent gene in S.pneumoniae R6 = spr0270; hypothetical protein complement(271775..272146) Streptococcus pneumoniae D39 4441148 YP_815792.1 CDS rplM NC_008533.1 272449 272895 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 272449..272895 Streptococcus pneumoniae D39 4442845 YP_815793.1 CDS rpsI NC_008533.1 272915 273307 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 272915..273307 Streptococcus pneumoniae D39 4441916 YP_815794.1 CDS SPD_0276 NC_008533.1 273994 274359 D equivalent gene in S.pneumoniae TIGR4 = SP0302; equivalent gene in S.pneumoniae R6 = spr0275; identified by match to protein family HMM PF03992; hypothetical protein 273994..274359 Streptococcus pneumoniae D39 4441267 YP_815795.1 CDS celA NC_008533.1 274549 275985 D converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 274549..275985 Streptococcus pneumoniae D39 4441165 YP_815796.1 CDS SPD_0278 NC_008533.1 276037 276276 D equivalent gene in S.pneumoniae TIGR4 = SP0304; equivalent gene in S.pneumoniae R6 = spr0277; identified by match to protein family HMM PF03083; hypothetical protein 276037..276276 Streptococcus pneumoniae D39 4442542 YP_815797.1 CDS celB NC_008533.1 276406 276720 D required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIB 276406..276720 Streptococcus pneumoniae D39 4441927 YP_815798.1 CDS SPD_0280 NC_008533.1 276844 278817 D equivalent gene in S.pneumoniae TIGR4 = SP0306; equivalent gene in S.pneumoniae R6 = spr0279; identified by match to protein family HMM PF00874; match to protein family HMM PF05043; transcriptional regulator 276844..278817 Streptococcus pneumoniae D39 4443078 YP_815799.1 CDS celC NC_008533.1 278827 279141 D required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIA component 278827..279141 Streptococcus pneumoniae D39 4441018 YP_815800.1 CDS SPD_0282 NC_008533.1 279160 279666 D equivalent gene in S.pneumoniae TIGR4 = SP0309; equivalent gene in S.pneumoniae R6 = spr0281; hypothetical protein 279160..279666 Streptococcus pneumoniae D39 4441311 YP_815801.1 CDS celD NC_008533.1 279746 281092 D required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIC component 279746..281092 Streptococcus pneumoniae D39 4441050 YP_815802.1 CDS SPD_0284 NC_008533.1 281474 281650 D equivalent gene in S.pneumoniae TIGR4 = SP0311; equivalent gene in S.pneumoniae R6 = spr0283; hypothetical protein 281474..281650 Streptococcus pneumoniae D39 4441031 YP_815803.1 CDS SPD_0285 NC_008533.1 282052 284265 D equivalent gene in S.pneumoniae TIGR4 = SP0312; equivalent gene in S.pneumoniae R6 = spr0284; identified by match to protein family HMM PF01055; glycosyl hydrolase family protein 282052..284265 Streptococcus pneumoniae D39 4442390 YP_815804.1 CDS SPD_0286 NC_008533.1 284487 284963 R equivalent gene in S.pneumoniae TIGR4 = SP0313; equivalent gene in S.pneumoniae R6 = spr0285; identified by match to protein family HMM PF00255; glutathione peroxidase complement(284487..284963) Streptococcus pneumoniae D39 4442131 YP_815805.1 CDS SPD_0287 NC_008533.1 285186 288389 D equivalent gene in S.pneumoniae TIGR4 = SP0314; equivalent gene in S.pneumoniae R6 = spr0286; identified by match to protein family HMM PF00746; match to protein family HMM PF02018; match to protein family HMM PF02278; match to protein family HMM PF02884; match to protein family HMM PF08124; match to protein family HMM TIGR01167; hyaluronate lyase 285186..288389 Streptococcus pneumoniae D39 4442428 YP_815806.1 CDS eda NC_008533.1 289533 290162 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(289533..290162) Streptococcus pneumoniae D39 4442880 YP_815807.1 CDS SPD_0290 NC_008533.1 290172 291173 R equivalent gene in S.pneumoniae TIGR4 = SP0318; equivalent gene in S.pneumoniae R6 = spr0288; identified by match to protein family HMM PF00294; PfkB family protein carbohydrate kinase complement(290172..291173) Streptococcus pneumoniae D39 4442572 YP_815808.1 CDS SPD_0291 NC_008533.1 291204 291845 R equivalent gene in S.pneumoniae TIGR4 = SP0319; equivalent gene in S.pneumoniae R6 = spr0289; identified by match to protein family HMM PF06562; hypothetical protein complement(291204..291845) Streptococcus pneumoniae D39 4441093 YP_815809.1 CDS SPD_0292 NC_008533.1 291864 292679 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(291864..292679) Streptococcus pneumoniae D39 4442159 YP_815810.1 CDS SPD_0293 NC_008533.1 292950 293384 D equivalent gene in S.pneumoniae TIGR4 = SP0321; equivalent gene in S.pneumoniae R6 = spr0291; identified by match to protein family HMM PF03610; PTS system transporter subunit IIA 292950..293384 Streptococcus pneumoniae D39 4442732 YP_815811.1 CDS SPD_0294 NC_008533.1 293396 294586 D equivalent gene in S.pneumoniae TIGR4 = SP0322; equivalent gene in S.pneumoniae R6 = spr0292; identified by match to protein family HMM PF07470; glucuronyl hydrolase 293396..294586 Streptococcus pneumoniae D39 4441936 YP_815812.1 CDS SPD_0295 NC_008533.1 294597 295088 D equivalent gene in S.pneumoniae TIGR4 = SP0323; equivalent gene in S.pneumoniae R6 = spr0293; identified by match to protein family HMM PF03830; PTS system transporter subunit IIB 294597..295088 Streptococcus pneumoniae D39 4441114 YP_815813.1 CDS SPD_0296 NC_008533.1 295103 295882 D equivalent gene in S.pneumoniae TIGR4 = SP0324; equivalent gene in S.pneumoniae R6 = spr0294; identified by match to protein family HMM PF03609; PTS system transporter subunit IIC 295103..295882 Streptococcus pneumoniae D39 4442474 YP_815814.1 CDS SPD_0297 NC_008533.1 295869 296687 D equivalent gene in S.pneumoniae TIGR4 = SP0325; equivalent gene in S.pneumoniae R6 = spr0295; identified by match to protein family HMM PF03613; PTS system transporter subunit IID 295869..296687 Streptococcus pneumoniae D39 4442681 YP_815815.2 CDS yajC-1 NC_008533.1 296687 296980 D equivalent gene in S.pneumoniae TIGR4 = SP0326; equivalent gene in S.pneumoniae R6 = spr0296; preprotein translocase subunit YajC 296687..296980 Streptococcus pneumoniae D39 4442710 YP_815816.1 CDS SPD_0299 NC_008533.1 297002 297118 D hypothetical protein 297002..297118 Streptococcus pneumoniae D39 4442187 YP_815817.1 CDS SPD_0300 NC_008533.1 297064 298902 D equivalent gene in S.pneumoniae TIGR4 = SP0327; equivalent gene in S.pneumoniae R6 = spr0297; identified by match to protein family HMM PF07940; hypothetical protein 297064..298902 Streptococcus pneumoniae D39 4442153 YP_815818.1 CDS regR NC_008533.1 298962 299963 D equivalent gene in S.pneumoniae TIGR4 = SP0330; equivalent gene in S.pneumoniae R6 = spr0298; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar binding transcriptional regulator RegR 298962..299963 Streptococcus pneumoniae D39 4441432 YP_815819.1 CDS SPD_0302 NC_008533.1 300409 300651 R equivalent gene in S.pneumoniae R6 = spr0300; hypothetical protein complement(300409..300651) Streptococcus pneumoniae D39 4441230 YP_815820.1 CDS SPD_0303 NC_008533.1 300667 300861 R equivalent gene in S.pneumoniae TIGR4 = SP0333; equivalent gene in S.pneumoniae R6 = spr0301; identified by match to protein family HMM PF01381; transcriptional regulator complement(300667..300861) Streptococcus pneumoniae D39 4443002 YP_815821.1 CDS mraW NC_008533.1 301027 301977 D equivalent gene in S.pneumoniae TIGR4 = SP0334; equivalent gene in S.pneumoniae R6 = spr0302; identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 301027..301977 Streptococcus pneumoniae D39 4441289 YP_815822.1 CDS ftsL NC_008533.1 301989 302306 D equivalent gene in S.pneumoniae TIGR4 = SP0335; equivalent gene in S.pneumoniae R6 = spr0303; identified by match to protein family HMM TIGR02209; cell division protein FtsL 301989..302306 Streptococcus pneumoniae D39 4441478 YP_815823.1 CDS pbpX NC_008533.1 302310 304562 D equivalent gene in S.pneumoniae TIGR4 = SP0336; equivalent gene in S.pneumoniae R6 = spr0304; identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793; penicillin-binding protein 2X 302310..304562 Streptococcus pneumoniae D39 4442351 YP_815824.1 CDS mraY NC_008533.1 304564 305544 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 304564..305544 Streptococcus pneumoniae D39 4441350 YP_815825.1 CDS clpL NC_008533.1 306101 308206 D equivalent gene in S.pneumoniae TIGR4 = SP0338; equivalent gene in S.pneumoniae R6 = spr0307; identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease, ATP-binding subunit 306101..308206 Streptococcus pneumoniae D39 4441410 YP_815826.1 CDS luxS NC_008533.1 308502 308984 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(308502..308984) Streptococcus pneumoniae D39 4441459 YP_815827.1 CDS SPD_0310 NC_008533.1 309079 310563 R equivalent gene in S.pneumoniae TIGR4 = SP0341; equivalent gene in S.pneumoniae R6 = spr0309; hypothetical protein complement(309079..310563) Streptococcus pneumoniae D39 4441141 YP_815828.1 CDS dexB NC_008533.1 310716 312323 D equivalent gene in S.pneumoniae TIGR4 = SP0342; equivalent gene in S.pneumoniae R6 = spr0310; identified by match to protein family HMM PF00128; glucan 1,6-alpha-glucosidase 310716..312323 Streptococcus pneumoniae D39 4441956 YP_815829.1 CDS SPD_0313 NC_008533.1 312482 312655 D equivalent gene in S.pneumoniae R6 = spr0311; hypothetical protein 312482..312655 Streptococcus pneumoniae D39 4442317 YP_815830.1 CDS cps2A NC_008533.1 313744 315189 D equivalent gene in S.pneumoniae TIGR4 = SP0346; equivalent gene in S.pneumoniae R6 = spr0314; identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350; integral membrane regulatory protein Cps2A 313744..315189 Streptococcus pneumoniae D39 4442916 YP_815831.1 CDS cps2B NC_008533.1 315191 315922 D equivalent gene in S.pneumoniae TIGR4 = SP0347; identified by match to protein family HMM PF02811; tyrosine-protein phosphatase CpsB 315191..315922 Streptococcus pneumoniae D39 4442833 YP_815832.1 CDS cps2C NC_008533.1 315931 316623 D identified by match to protein family HMM PF02706; match to protein family HMM TIGR01006; chain length determinant protein/polysaccharide export protein, MPA1 family protein 315931..316623 Streptococcus pneumoniae D39 4442353 YP_815833.1 CDS cps2D NC_008533.1 316633 317313 D identified by match to protein family HMM TIGR01007; tyrosine-protein kinase Cps2D cytosolic ATPase 316633..317313 Streptococcus pneumoniae D39 4441968 YP_815834.1 CDS cps2E NC_008533.1 317328 318695 D Cps2E catalyzes the reversible addition of Glc-1-phosphate from UDP-Glc to a polyprenyl phosphate acceptor; identified by match to protein family HMM PF02397; undecaprenylphosphate glucosephosphotransferase Cps2E 317328..318695 Streptococcus pneumoniae D39 4442284 YP_815835.1 CDS cps2T NC_008533.1 318727 319911 D identified by match to protein family HMM PF00534; glycoside hydrolase family protein 318727..319911 Streptococcus pneumoniae D39 4442573 YP_815836.1 CDS cps2F NC_008533.1 319904 320848 D identified by match to protein family HMM PF00535; glycosyl transferase family protein 319904..320848 Streptococcus pneumoniae D39 4441761 YP_815837.1 CDS cps2G NC_008533.1 320864 321910 D identified by match to protein family HMM PF00534; glycoside hydrolase family protein 320864..321910 Streptococcus pneumoniae D39 4441367 YP_815838.1 CDS csp2H NC_008533.1 321951 323114 D Part of the type 2 capsule locus. equivalent gene in S.pneumoniae R6 = spr0315; polysaccharide polymerase 321951..323114 Streptococcus pneumoniae D39 4441238 YP_815839.1 CDS cps2I NC_008533.1 323244 324401 D equivalent gene in S.pneumoniae R6 = spr0316; identified by match to protein family HMM PF00534; glycoside hydrolase family protein 323244..324401 Streptococcus pneumoniae D39 4442293 YP_815840.1 CDS SPD_0325 NC_008533.1 324398 325807 D equivalent gene in S.pneumoniae R6 = spr0317; identified by match to protein family HMM PF01943; hypothetical protein 324398..325807 Streptococcus pneumoniae D39 4442154 YP_815841.1 CDS cps2K NC_008533.1 325843 327081 D equivalent gene in S.pneumoniae R6 = spr0318; identified by match to protein family HMM PF00984; match to protein family HMM PF01210; match to protein family HMM PF03720; match to protein family HMM PF03721; UDP-glucose 6-dehydrogenase 325843..327081 Streptococcus pneumoniae D39 4441693 YP_815842.1 CDS cps2P NC_008533.1 327110 327715 D equivalent gene in S.pneumoniae R6 = spr0319; identified by match to protein family HMM PF03275; UDP-galactopyranose mutase 327110..327715 Streptococcus pneumoniae D39 4441861 YP_815843.1 CDS cps2L NC_008533.1 327793 328662 D equivalent gene in S.pneumoniae R6 = spr0320; identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase 327793..328662 Streptococcus pneumoniae D39 4442760 YP_815844.1 CDS rfbC NC_008533.1 328663 329256 D equivalent gene in S.pneumoniae R6 = spr0321; identified by match to protein family HMM PF00908; dTDP-4-dehydrorhamnose 3,5-epimerase 328663..329256 Streptococcus pneumoniae D39 4441822 YP_815845.1 CDS rfbB NC_008533.1 329269 330318 D equivalent gene in S.pneumoniae R6 = spr0322; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-glucose 4,6-dehydratase 329269..330318 Streptococcus pneumoniae D39 4442169 YP_815846.1 CDS rfbD NC_008533.1 330384 331235 D equivalent gene in S.pneumoniae R6 = spr0323; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01214; dTDP-4-dehydrorhamnose reductase 330384..331235 Streptococcus pneumoniae D39 4441055 YP_815847.1 CDS SPD_0333 NC_008533.1 332280 332438 D equivalent gene in S.pneumoniae TIGR4 = SP0808; equivalent gene in S.pneumoniae R6 = spr0326; hypothetical protein 332280..332438 Streptococcus pneumoniae D39 4441941 YP_815848.1 CDS aliA NC_008533.1 332640 334622 D equivalent gene in S.pneumoniae TIGR4 = SP0366; equivalent gene in S.pneumoniae R6 = spr0327; identified by match to protein family HMM PF00496; oligopeptide ABC transporter oligopeptide-binding protein AliA 332640..334622 Streptococcus pneumoniae D39 4442433 YP_815849.1 CDS SPD_0335 NC_008533.1 334922 340225 D equivalent gene in S.pneumoniae TIGR4 = SP0368; equivalent gene in S.pneumoniae R6 = spr0328; identified by match to protein family HMM PF00754; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 334922..340225 Streptococcus pneumoniae D39 4441186 YP_815850.1 CDS pbp1A NC_008533.1 340392 342551 R equivalent gene in S.pneumoniae TIGR4 = SP0369; equivalent gene in S.pneumoniae R6 = spr0329; identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 1A complement(340392..342551) Streptococcus pneumoniae D39 4442813 YP_815851.1 CDS recU NC_008533.1 342548 343144 R functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease complement(342548..343144) Streptococcus pneumoniae D39 4442724 YP_815852.1 CDS SPD_0338 NC_008533.1 343210 343737 D equivalent gene in S.pneumoniae TIGR4 = SP0371; equivalent gene in S.pneumoniae R6 = spr0331; identified by match to protein family HMM PF06908; hypothetical protein 343210..343737 Streptococcus pneumoniae D39 4442083 YP_815853.1 CDS SPD_0339 NC_008533.1 343807 344136 D equivalent gene in S.pneumoniae TIGR4 = SP0372; equivalent gene in S.pneumoniae R6 = spr0332; identified by match to protein family HMM PF05103; hypothetical protein 343807..344136 Streptococcus pneumoniae D39 4441564 YP_815854.1 CDS SPD_0341 NC_008533.1 344622 345779 D equivalent gene in S.pneumoniae TIGR4 = SP0373; equivalent gene in S.pneumoniae R6 = spr0333; identified by match to protein family HMM PF01170; hypothetical protein 344622..345779 Streptococcus pneumoniae D39 4441814 YP_815855.1 CDS SPD_0342 NC_008533.1 345792 347186 D equivalent gene in S.pneumoniae TIGR4 = SP0374; equivalent gene in S.pneumoniae R6 = spr0334; hypothetical protein 345792..347186 Streptococcus pneumoniae D39 4442806 YP_815856.1 CDS gnd NC_008533.1 347262 348686 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 347262..348686 Streptococcus pneumoniae D39 4441177 YP_815857.1 CDS SPD_0344 NC_008533.1 348698 349387 D equivalent gene in S.pneumoniae TIGR4 = SP0376; equivalent gene in S.pneumoniae R6 = spr0336; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 348698..349387 Streptococcus pneumoniae D39 4443059 YP_815858.1 CDS cbpC NC_008533.1 349485 350501 D equivalent gene in S.pneumoniae R6 = spr0337; identified by similarity to GB:AAK745441; match to protein family HMM PF01473; choline binding protein C 349485..350501 Streptococcus pneumoniae D39 4441308 YP_815859.1 CDS mvk NC_008533.1 350623 351501 D equivalent gene in S.pneumoniae TIGR4 = SP0381; equivalent gene in S.pneumoniae R6 = spr0338; identified by match to protein family HMM PF00288; match to protein family HMM TIGR00549; mevalonate kinase 350623..351501 Streptococcus pneumoniae D39 4442084 YP_815860.1 CDS mvaD NC_008533.1 351483 352436 D equivalent gene in S.pneumoniae TIGR4 = SP0382; equivalent gene in S.pneumoniae R6 = spr0339; identified by match to protein family HMM PF00288; match to protein family HMM TIGR01240; diphosphomevalonate decarboxylase 351483..352436 Streptococcus pneumoniae D39 4441675 YP_815861.1 CDS mvaK2 NC_008533.1 352423 353430 D equivalent gene in S.pneumoniae TIGR4 = SP0383; equivalent gene in S.pneumoniae R6 = spr0340; identified by match to protein family HMM PF00288; match to protein family HMM TIGR01220; phosphomevalonate kinase 352423..353430 Streptococcus pneumoniae D39 4441890 YP_815862.1 CDS fni NC_008533.1 353414 354424 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 353414..354424 Streptococcus pneumoniae D39 4441668 YP_815863.1 CDS SPD_0350 NC_008533.1 354502 355200 D equivalent gene in S.pneumoniae TIGR4 = SP0385; equivalent gene in S.pneumoniae R6 = spr0342; hypothetical protein 354502..355200 Streptococcus pneumoniae D39 4442001 YP_815864.1 CDS SPD_0351 NC_008533.1 355197 356192 D equivalent gene in S.pneumoniae TIGR4 = SP0386; equivalent gene in S.pneumoniae R6 = spr0343; identified by match to protein family HMM PF02518; match to protein family HMM PF07730; sensor histidine kinase 355197..356192 Streptococcus pneumoniae D39 4441118 YP_815865.1 CDS SPD_0352 NC_008533.1 356206 356838 D equivalent gene in S.pneumoniae TIGR4 = SP0387; equivalent gene in S.pneumoniae R6 = spr0344; identified by match to protein family HMM PF00072; match to protein family HMM PF00196; DNA-binding response regulator 356206..356838 Streptococcus pneumoniae D39 4442378 YP_815866.1 CDS SPD_0353 NC_008533.1 356839 356985 D equivalent gene in S.pneumoniae R6 = spr0345; hypothetical protein 356839..356985 Streptococcus pneumoniae D39 4442680 YP_815867.1 CDS SPD_0355 NC_008533.1 357758 357952 D equivalent gene in S.pneumoniae TIGR4 = SP0389; equivalent gene in S.pneumoniae R6 = spr0348; hypothetical protein 357758..357952 Streptococcus pneumoniae D39 4442625 YP_815868.1 CDS cbpF NC_008533.1 358922 359806 D equivalent gene in S.pneumoniae R6 = spr0351; identified by match to protein family HMM PF01473; choline binding protein F 358922..359806 Streptococcus pneumoniae D39 4441103 YP_815869.1 CDS SPD_0359 NC_008533.1 360868 361080 R equivalent gene in S.pneumoniae TIGR4 = SP1596; equivalent gene in S.pneumoniae R6 = spr0355; hypothetical protein complement(360868..361080) Streptococcus pneumoniae D39 4442687 YP_815870.1 CDS mtlA NC_008533.1 361289 363058 D equivalent gene in S.pneumoniae TIGR4 = SP0394; equivalent gene in S.pneumoniae R6 = spr0356; identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; PTS system mannitol-specific transporter subunit IIBC 361289..363058 Streptococcus pneumoniae D39 4441030 YP_815871.1 CDS SPD_0361 NC_008533.1 363082 365037 D equivalent gene in S.pneumoniae TIGR4 = SP0395; equivalent gene in S.pneumoniae R6 = spr0357; transcriptional regulator 363082..365037 Streptococcus pneumoniae D39 4442181 YP_815872.1 CDS mtlA2 NC_008533.1 365039 365476 D equivalent gene in S.pneumoniae TIGR4 = SP0396; equivalent gene in S.pneumoniae R6 = spr0358; identified by match to protein family HMM PF00359; PTS system, mannitol-specific enzyme IIA 365039..365476 Streptococcus pneumoniae D39 4442892 YP_815873.1 CDS SPD_0363 NC_008533.1 365538 366674 D equivalent gene in S.pneumoniae TIGR4 = SP0397; equivalent gene in S.pneumoniae R6 = spr0359; identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 365538..366674 Streptococcus pneumoniae D39 4443079 YP_815874.1 CDS SPD_0364 NC_008533.1 367056 367169 D equivalent gene in S.pneumoniae TIGR4 = SP0399; equivalent gene in S.pneumoniae R6 = spr0361; polar amino acid ABC transporter ATPase 367056..367169 Streptococcus pneumoniae D39 4441511 YP_815875.1 CDS tig NC_008533.1 367473 368756 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 367473..368756 Streptococcus pneumoniae D39 4442266 YP_815876.1 CDS SPD_0366 NC_008533.1 368804 371170 R equivalent gene in S.pneumoniae TIGR4 = SP0401; equivalent gene in S.pneumoniae R6 = spr0363; identified by match to protein family HMM TIGR01448; helicase, RecD/TraA family protein complement(368804..371170) Streptococcus pneumoniae D39 4442866 YP_815877.1 CDS lepB NC_008533.1 371404 372018 R equivalent gene in S.pneumoniae TIGR4 = SP0402; equivalent gene in S.pneumoniae R6 = spr0364; identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; signal peptidase I complement(371404..372018) Streptococcus pneumoniae D39 4442547 YP_815878.1 CDS rnhC NC_008533.1 372030 372902 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII complement(372030..372902) Streptococcus pneumoniae D39 4442208 YP_815879.1 CDS SPD_0369 NC_008533.1 372980 373291 D equivalent gene in S.pneumoniae TIGR4 = SP0404; equivalent gene in S.pneumoniae R6 = spr0366; hypothetical protein 372980..373291 Streptococcus pneumoniae D39 4442068 YP_815880.1 CDS SPD_0370 NC_008533.1 373288 373836 D equivalent gene in S.pneumoniae TIGR4 = SP0405; equivalent gene in S.pneumoniae R6 = spr0367; identified by match to protein family HMM PF02674; hypothetical protein 373288..373836 Streptococcus pneumoniae D39 4442464 YP_815881.1 CDS SPD_0371 NC_008533.1 373940 376276 D equivalent gene in S.pneumoniae TIGR4 = SP0406; equivalent gene in S.pneumoniae R6 = spr0368; identified by match to protein family HMM PF00488; match to protein family HMM PF01713; match to protein family HMM TIGR01069; MutS2 family protein 373940..376276 Streptococcus pneumoniae D39 4441818 YP_815882.1 CDS SPD_0372 NC_008533.1 376618 377940 D equivalent gene in S.pneumoniae TIGR4 = SP0408; equivalent gene in S.pneumoniae R6 = spr0369; identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; sodium:alanine symporter family protein 376618..377940 Streptococcus pneumoniae D39 4442666 YP_815883.1 CDS SPD_0373 NC_008533.1 378158 378706 D equivalent gene in S.pneumoniae TIGR4 = SP0409; equivalent gene in S.pneumoniae R6 = spr0370; identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778; hypothetical protein 378158..378706 Streptococcus pneumoniae D39 4442629 YP_815884.1 CDS SPD_0374 NC_008533.1 378816 379715 D equivalent gene in S.pneumoniae TIGR4 = SP0410; equivalent gene in S.pneumoniae R6 = spr0371; identified by match to protein family HMM PF03595; exfoliative toxin 378816..379715 Streptococcus pneumoniae D39 4442392 YP_815885.1 CDS serS NC_008533.1 379740 381014 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(379740..381014) Streptococcus pneumoniae D39 4442808 YP_815886.1 CDS SPD_0376 NC_008533.1 381227 381598 R equivalent gene in S.pneumoniae TIGR4 = SP0412; equivalent gene in S.pneumoniae R6 = spr0373; identified by match to protein family HMM PF06115; hypothetical protein complement(381227..381598) Streptococcus pneumoniae D39 4441593 YP_815887.1 CDS SPD_0377 NC_008533.1 381601 382965 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase complement(381601..382965) Streptococcus pneumoniae D39 4441559 YP_815888.1 CDS SPD_0378 NC_008533.1 383290 384075 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 383290..384075 Streptococcus pneumoniae D39 4442397 YP_815889.1 CDS SPD_0379 NC_008533.1 384169 384603 D equivalent gene in S.pneumoniae TIGR4 = SP0416; equivalent gene in S.pneumoniae R6 = spr0376; identified by match to protein family HMM PF01047; match to protein family HMM PF03965; transcriptional regulator, MarR family protein 384169..384603 Streptococcus pneumoniae D39 4441687 YP_815890.1 CDS fabH NC_008533.1 384603 385577 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 384603..385577 Streptococcus pneumoniae D39 4441504 YP_815891.1 CDS acpP NC_008533.1 385637 385861 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 385637..385861 Streptococcus pneumoniae D39 4442166 YP_815892.1 CDS fabK NC_008533.1 385980 386954 D equivalent gene in S.pneumoniae TIGR4 = SP0419; equivalent gene in S.pneumoniae R6 = spr0379; identified by match to protein family HMM PF03060; trans-2-enoyl-ACP reductase II 385980..386954 Streptococcus pneumoniae D39 4442635 YP_815893.1 CDS fabD NC_008533.1 386947 387867 D equivalent gene in S.pneumoniae TIGR4 = SP0420; equivalent gene in S.pneumoniae R6 = spr0380; identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; acyl-carrier-protein S-malonyltransferase 386947..387867 Streptococcus pneumoniae D39 4442363 YP_815894.1 CDS fabG NC_008533.1 387901 388632 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 387901..388632 Streptococcus pneumoniae D39 4441618 YP_815895.1 CDS fabF NC_008533.1 388654 389889 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 388654..389889 Streptococcus pneumoniae D39 4442768 YP_815896.1 CDS accB NC_008533.1 389892 390377 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 389892..390377 Streptococcus pneumoniae D39 4441640 YP_815897.1 CDS fabZ NC_008533.1 390374 390796 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 390374..390796 Streptococcus pneumoniae D39 4442197 YP_815898.1 CDS accC NC_008533.1 390808 392175 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 390808..392175 Streptococcus pneumoniae D39 4441071 YP_815899.1 CDS accD NC_008533.1 392212 393078 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 392212..393078 Streptococcus pneumoniae D39 4442872 YP_815900.1 CDS accA NC_008533.1 393075 393842 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 393075..393842 Streptococcus pneumoniae D39 4441320 YP_815901.1 CDS SPD_0391 NC_008533.1 394001 394186 D equivalent gene in S.pneumoniae TIGR4 = SP0429; equivalent gene in S.pneumoniae R6 = spr0388; hypothetical protein 394001..394186 Streptococcus pneumoniae D39 4441492 YP_815902.1 CDS SPD_0392 NC_008533.1 394443 394655 D equivalent gene in S.pneumoniae TIGR4 = SP0430; equivalent gene in S.pneumoniae R6 = spr0389; hypothetical protein 394443..394655 Streptococcus pneumoniae D39 4442180 YP_815903.1 CDS nusB NC_008533.1 394953 395375 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(394953..395375) Streptococcus pneumoniae D39 4441487 YP_815904.1 CDS SPD_0394 NC_008533.1 395368 395757 R equivalent gene in S.pneumoniae TIGR4 = SP0434; equivalent gene in S.pneumoniae R6 = spr0391; identified by match to protein family HMM PF03780; hypothetical protein complement(395368..395757) Streptococcus pneumoniae D39 4441515 YP_815905.1 CDS efp NC_008533.1 395779 396339 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(395779..396339) Streptococcus pneumoniae D39 4441136 YP_815906.1 CDS gatB NC_008533.1 396468 397910 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(396468..397910) Streptococcus pneumoniae D39 4442706 YP_815907.1 CDS gatA NC_008533.1 397910 399376 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(397910..399376) Streptococcus pneumoniae D39 4442568 YP_815908.1 CDS gatC NC_008533.1 399376 399678 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(399376..399678) Streptococcus pneumoniae D39 4441536 YP_815909.1 CDS prfC NC_008533.1 399891 401435 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 399891..401435 Streptococcus pneumoniae D39 4442020 YP_815910.1 CDS SPD_0400 NC_008533.1 401704 402189 D equivalent gene in S.pneumoniae R6 = spr0397; identified by match to protein family HMM PF01501; glycosyl transferase family protein 8 401704..402189 Streptococcus pneumoniae D39 4441208 YP_815911.1 CDS rpmB NC_008533.1 402305 402493 D required for 70S ribosome assembly; 50S ribosomal protein L28 402305..402493 Streptococcus pneumoniae D39 4441538 YP_815912.1 CDS SPD_0402 NC_008533.1 402650 403015 D equivalent gene in S.pneumoniae TIGR4 = SP0442; equivalent gene in S.pneumoniae R6 = spr0399; identified by match to protein family HMM PF03780; hypothetical protein 402650..403015 Streptococcus pneumoniae D39 4442692 YP_815913.1 CDS SPD_0403 NC_008533.1 403018 404685 D equivalent gene in S.pneumoniae TIGR4 = SP0443; equivalent gene in S.pneumoniae R6 = spr0400; identified by match to protein family HMM PF02734; hypothetical protein 403018..404685 Streptococcus pneumoniae D39 4442013 YP_815914.1 CDS ilvB NC_008533.1 404886 406586 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 404886..406586 Streptococcus pneumoniae D39 4442959 YP_815915.1 CDS ilvH NC_008533.1 406579 407055 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 406579..407055 Streptococcus pneumoniae D39 4441254 YP_815916.1 CDS ilvC NC_008533.1 407121 408143 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 407121..408143 Streptococcus pneumoniae D39 4441869 YP_815917.1 CDS SPD_0407 NC_008533.1 408220 408486 D equivalent gene in S.pneumoniae TIGR4 = SP0448; equivalent gene in S.pneumoniae R6 = spr0404; hypothetical protein 408220..408486 Streptococcus pneumoniae D39 4442869 YP_815918.1 CDS SPD_0408 NC_008533.1 408724 409080 D equivalent gene in S.pneumoniae TIGR4 = SP0449; equivalent gene in S.pneumoniae R6 = spr0405; identified by similarity to GB:AAK992091; hypothetical protein 408724..409080 Streptococcus pneumoniae D39 4442479 YP_815919.1 CDS ilvA NC_008533.1 409130 410380 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 409130..410380 Streptococcus pneumoniae D39 4442620 YP_815920.1 CDS SPD_0410 NC_008533.1 411115 411330 D equivalent gene in S.pneumoniae TIGR4 = SP0451; equivalent gene in S.pneumoniae R6 = spr0407; hypothetical protein 411115..411330 Streptococcus pneumoniae D39 4441213 YP_815921.1 CDS SPD_0411 NC_008533.1 411439 412179 R equivalent gene in S.pneumoniae TIGR4 = SP0452; equivalent gene in S.pneumoniae R6 = spr0408; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein complement(411439..412179) Streptococcus pneumoniae D39 4442454 YP_815922.1 CDS SPD_0412 NC_008533.1 412179 413744 R equivalent gene in S.pneumoniae TIGR4 = SP0453; equivalent gene in S.pneumoniae R6 = spr0409; identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter amino acid-binding protein/permease complement(412179..413744) Streptococcus pneumoniae D39 4441473 YP_815923.1 CDS SPD_0414 NC_008533.1 413882 415771 D equivalent gene in S.pneumoniae TIGR4 = SP0454; equivalent gene in S.pneumoniae R6 = spr0410; hypothetical protein 413882..415771 Streptococcus pneumoniae D39 4443081 YP_815924.1 CDS SPD_0413 NC_008533.1 415768 415929 R equivalent gene in S.pneumoniae R6 = spr0411; hypothetical protein complement(415768..415929) Streptococcus pneumoniae D39 4441943 YP_815925.1 CDS bacA NC_008533.1 417195 418040 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 417195..418040 Streptococcus pneumoniae D39 4441316 YP_815926.1 CDS SPD_0418 NC_008533.1 418033 418161 D equivalent gene in S.pneumoniae R6 = spr0346; hypothetical protein 418033..418161 Streptococcus pneumoniae D39 4442933 YP_815927.1 CDS dinP NC_008533.1 418187 419248 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(418187..419248) Streptococcus pneumoniae D39 4442686 YP_815928.1 CDS pflB NC_008533.1 419643 421967 D equivalent gene in S.pneumoniae TIGR4 = SP0459; equivalent gene in S.pneumoniae R6 = spr0415; identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 419643..421967 Streptococcus pneumoniae D39 4441825 YP_815929.1 CDS SPD_0421 NC_008533.1 422334 422681 R equivalent gene in S.pneumoniae R6 = spr0416; hypothetical protein complement(422334..422681) Streptococcus pneumoniae D39 4441460 YP_815930.1 CDS SPD_0422 NC_008533.1 422879 423163 R equivalent gene in S.pneumoniae TIGR4 = SP0471; equivalent gene in S.pneumoniae R6 = spr0417; hypothetical protein complement(422879..423163) Streptococcus pneumoniae D39 4442994 YP_815931.1 CDS SPD_0423 NC_008533.1 424598 425821 R equivalent gene in S.pneumoniae TIGR4 = SP0473; equivalent gene in S.pneumoniae R6 = spr0420; identified by match to protein family HMM PF00480; ROK family protein complement(424598..425821) Streptococcus pneumoniae D39 4441990 YP_815932.1 CDS SPD_0424 NC_008533.1 425989 427311 D equivalent gene in S.pneumoniae TIGR4 = SP0474; equivalent gene in S.pneumoniae R6 = spr0421; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system cellobiose-specific transporter subunit IIC 425989..427311 Streptococcus pneumoniae D39 4441403 YP_815933.1 CDS SPD_0425 NC_008533.1 427313 429199 D equivalent gene in S.pneumoniae TIGR4 = SP0475; equivalent gene in S.pneumoniae R6 = spr0422; hypothetical protein 427313..429199 Streptococcus pneumoniae D39 4442858 YP_815934.1 CDS lacF-1 NC_008533.1 429367 429711 D equivalent gene in S.pneumoniae TIGR4 = SP0476; equivalent gene in S.pneumoniae R6 = spr0423; identified by match to protein family HMM PF02255; PTS system lactose-specific transporter subunit IIA 429367..429711 Streptococcus pneumoniae D39 4442087 YP_815935.1 CDS lacG-1 NC_008533.1 429721 431133 D catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 429721..431133 Streptococcus pneumoniae D39 4443011 YP_815936.1 CDS lacE-1 NC_008533.1 431202 432881 D equivalent gene in S.pneumoniae TIGR4 = SP0478; equivalent gene in S.pneumoniae R6 = spr0425; identified by match to protein family HMM PF02302; match to protein family HMM PF02378; PTS system lactose-specific transporter subunit IIBC 431202..432881 Streptococcus pneumoniae D39 4442703 YP_815937.1 CDS SPD_0429 NC_008533.1 433009 434448 R equivalent gene in S.pneumoniae TIGR4 = SP0479; equivalent gene in S.pneumoniae R6 = spr0426; identified by match to protein family HMM PF02386; potassium uptake protein, Trk family protein complement(433009..434448) Streptococcus pneumoniae D39 4441891 YP_815938.1 CDS trkA NC_008533.1 434452 435801 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein complement(434452..435801) Streptococcus pneumoniae D39 4442659 YP_815939.1 CDS SPD_0431 NC_008533.1 435990 436838 D equivalent gene in S.pneumoniae TIGR4 = SP0481; equivalent gene in S.pneumoniae R6 = spr0428; identified by match to protein family HMM PF01887; hypothetical protein 435990..436838 Streptococcus pneumoniae D39 4442368 YP_815940.1 CDS SPD_0432 NC_008533.1 436853 437401 D equivalent gene in S.pneumoniae TIGR4 = SP0482; equivalent gene in S.pneumoniae R6 = spr0429; identified by match to protein family HMM PF07155; hypothetical protein 436853..437401 Streptococcus pneumoniae D39 4441502 YP_815941.1 CDS SPD_0433 NC_008533.1 437408 437620 D hypothetical protein 437408..437620 Streptococcus pneumoniae D39 4441360 YP_815942.1 CDS SPD_0434 NC_008533.1 437722 439404 D equivalent gene in S.pneumoniae TIGR4 = SP0483; equivalent gene in S.pneumoniae R6 = spr0430; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 437722..439404 Streptococcus pneumoniae D39 4442207 YP_815943.1 CDS SPD_0435 NC_008533.1 439389 440219 D equivalent gene in S.pneumoniae TIGR4 = SP0484; equivalent gene in S.pneumoniae R6 = spr0431; identified by match to protein family HMM PF02361; hypothetical protein 439389..440219 Streptococcus pneumoniae D39 4442267 YP_815944.1 CDS SPD_0436 NC_008533.1 440412 440915 D equivalent gene in S.pneumoniae TIGR4 = SP0486; equivalent gene in S.pneumoniae R6 = spr0432; identified by match to protein family HMM PF00588; TrmH family RNA methyltransferase 440412..440915 Streptococcus pneumoniae D39 4442462 YP_815945.1 CDS SPD_0437 NC_008533.1 441374 441937 D equivalent gene in S.pneumoniae TIGR4 = SP0488; equivalent gene in S.pneumoniae R6 = spr0433; hypothetical protein 441374..441937 Streptococcus pneumoniae D39 4442973 YP_815946.1 CDS SPD_0438 NC_008533.1 441927 442577 D equivalent gene in S.pneumoniae TIGR4 = SP0489; equivalent gene in S.pneumoniae R6 = spr0434; identified by match to protein family HMM PF01569; PAP2 family protein 441927..442577 Streptococcus pneumoniae D39 4442360 YP_815947.1 CDS SPD_0439 NC_008533.1 442605 442994 D equivalent gene in S.pneumoniae TIGR4 = SP0490; equivalent gene in S.pneumoniae R6 = spr0435; hypothetical protein 442605..442994 Streptococcus pneumoniae D39 4441824 YP_815948.1 CDS SPD_0440 NC_008533.1 442999 443448 D equivalent gene in S.pneumoniae TIGR4 = SP0492; equivalent gene in S.pneumoniae R6 = spr0436; hypothetical protein 442999..443448 Streptococcus pneumoniae D39 4441106 YP_815949.1 CDS SPD_0441 NC_008533.1 443576 444163 D participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 443576..444163 Streptococcus pneumoniae D39 4442445 YP_815950.1 CDS pyrG NC_008533.1 444553 446160 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 444553..446160 Streptococcus pneumoniae D39 4441199 YP_815951.1 CDS SPD_0443 NC_008533.1 446719 448350 R equivalent gene in S.pneumoniae TIGR4 = SP0496; equivalent gene in S.pneumoniae R6 = spr0439; identified by match to protein family HMM PF02690; match to protein family HMM TIGR00704; Na/Pi-cotransporter II-like protein complement(446719..448350) Streptococcus pneumoniae D39 4442737 YP_815952.1 CDS SPD_0444 NC_008533.1 448715 453622 D equivalent gene in S.pneumoniae TIGR4 = SP0498; equivalent gene in S.pneumoniae R6 = spr0440; identified by match to protein family HMM PF00746; match to protein family HMM PF00754; match to protein family HMM PF03644; match to protein family HMM PF07501; match to protein family HMM PF07523; match to protein family HMM PF07554; match to protein family HMM TIGR01167; endo-beta-N-acetylglucosaminidase 448715..453622 Streptococcus pneumoniae D39 4442040 YP_815953.1 CDS pgk NC_008533.1 453712 454908 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 453712..454908 Streptococcus pneumoniae D39 4442109 YP_815954.1 CDS SPD_0446 NC_008533.1 455044 455571 D equivalent gene in S.pneumoniae TIGR4 = SP0500; equivalent gene in S.pneumoniae R6 = spr0442; hypothetical protein 455044..455571 Streptococcus pneumoniae D39 4441299 YP_815955.1 CDS SPD_0447 NC_008533.1 455648 456004 D equivalent gene in S.pneumoniae TIGR4 = SP0501; equivalent gene in S.pneumoniae R6 = spr0443; identified by match to protein family HMM PF00376; transcriptional regulator, MerR family protein 455648..456004 Streptococcus pneumoniae D39 4441873 YP_815956.1 CDS glnA NC_008533.1 456041 457387 D equivalent gene in S.pneumoniae TIGR4 = SP0502; equivalent gene in S.pneumoniae R6 = spr0444; identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; glutamine synthetase, type I 456041..457387 Streptococcus pneumoniae D39 4442684 YP_815957.1 CDS SPD_0449 NC_008533.1 457860 457997 D hypothetical protein 457860..457997 Streptococcus pneumoniae D39 4442209 YP_815958.1 CDS SPD_0451 NC_008533.1 458167 459447 D equivalent gene in S.pneumoniae R6 = spr0445; identified by match to protein family HMM PF01420; type I restriction-modification system subunit S 458167..459447 Streptococcus pneumoniae D39 4441377 YP_815959.1 CDS SPD_0450 NC_008533.1 459401 460000 R equivalent gene in S.pneumoniae TIGR4 = SP0507; equivalent gene in S.pneumoniae R6 = spr0446; identified by match to protein family HMM PF01420; type I restriction-modification system subunit S complement(459401..460000) Streptococcus pneumoniae D39 4442032 YP_815960.1 CDS SPD_0452 NC_008533.1 460011 460808 R equivalent gene in S.pneumoniae TIGR4 = SP0506; equivalent gene in S.pneumoniae R6 = spr0447; identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family protein complement(460011..460808) Streptococcus pneumoniae D39 4442417 YP_815961.1 CDS hsdS NC_008533.1 460865 462433 R equivalent gene in S.pneumoniae R6 = spr0448; identified by match to protein family HMM PF01420; type I restriction-modification system subunit S complement(460865..462433) Streptococcus pneumoniae D39 4443004 YP_815962.1 CDS hsdM NC_008533.1 462433 463896 R equivalent gene in S.pneumoniae TIGR4 = SP0509; equivalent gene in S.pneumoniae R6 = spr0449; identified by match to protein family HMM PF02384; match to protein family HMM PF05175; type I restriction-modification system, M subunit complement(462433..463896) Streptococcus pneumoniae D39 4441259 YP_815963.1 CDS hsdR NC_008533.1 463909 466242 R equivalent gene in S.pneumoniae TIGR4 = SP0510; equivalent gene in S.pneumoniae R6 = spr0450; identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system, R subunit complement(463909..466242) Streptococcus pneumoniae D39 4441326 YP_815964.1 CDS SPD_0456 NC_008533.1 466615 466815 D equivalent gene in S.pneumoniae TIGR4 = SP0512; equivalent gene in S.pneumoniae R6 = spr0451; hypothetical protein 466615..466815 Streptococcus pneumoniae D39 4442063 YP_815965.1 CDS SPD_0457 NC_008533.1 466850 467359 D equivalent gene in S.pneumoniae TIGR4 = SP0514; equivalent gene in S.pneumoniae R6 = spr0452; hypothetical protein 466850..467359 Streptococcus pneumoniae D39 4442495 YP_815966.1 CDS hrcA NC_008533.1 467523 468557 D Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 467523..468557 Streptococcus pneumoniae D39 4442288 YP_815967.1 CDS grpE NC_008533.1 468584 469108 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 468584..469108 Streptococcus pneumoniae D39 4441918 YP_815968.1 CDS dnaK NC_008533.1 469588 471411 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 469588..471411 Streptococcus pneumoniae D39 4442619 YP_815969.1 CDS dnaJ NC_008533.1 472171 473289 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 472171..473289 Streptococcus pneumoniae D39 4442186 YP_815970.1 CDS SPD_0462 NC_008533.1 473624 473911 R equivalent gene in S.pneumoniae TIGR4 = SP0520; equivalent gene in S.pneumoniae R6 = spr0457; hypothetical protein complement(473624..473911) Streptococcus pneumoniae D39 4441517 YP_815971.1 CDS SPD_0463 NC_008533.1 473921 474331 R equivalent gene in S.pneumoniae TIGR4 = SP0521; equivalent gene in S.pneumoniae R6 = spr0458; identified by match to protein family HMM PF01230; cell-cycle regulation Hit-like protein complement(473921..474331) Streptococcus pneumoniae D39 4443040 YP_815972.1 CDS SPD_0464 NC_008533.1 474399 475130 D equivalent gene in S.pneumoniae TIGR4 = SP0522; equivalent gene in S.pneumoniae R6 = spr0459; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 474399..475130 Streptococcus pneumoniae D39 4441034 YP_815973.1 CDS SPD_0465 NC_008533.1 475127 476176 D equivalent gene in S.pneumoniae TIGR4 = SP0523; equivalent gene in S.pneumoniae R6 = spr0460; identified by match to protein family HMM PF05975; ABC transporter permease 475127..476176 Streptococcus pneumoniae D39 4442097 YP_815974.1 CDS SPD_0466 NC_008533.1 476344 476673 R equivalent gene in S.pneumoniae TIGR4 = SP0524; equivalent gene in S.pneumoniae R6 = spr0461; hypothetical protein complement(476344..476673) Streptococcus pneumoniae D39 4441682 YP_815975.1 CDS blpS NC_008533.1 476949 477287 D equivalent gene in S.pneumoniae TIGR4 = SP0525; equivalent gene in S.pneumoniae R6 = spr0462; identified by match to protein family HMM PF04397; BlpS protein 476949..477287 Streptococcus pneumoniae D39 4441234 YP_815976.1 CDS blpR NC_008533.1 477292 478029 D equivalent gene in S.pneumoniae TIGR4 = SP0526; equivalent gene in S.pneumoniae R6 = spr0463; identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator BlpR 477292..478029 Streptococcus pneumoniae D39 4442673 YP_815977.1 CDS blpH NC_008533.1 478043 479383 D equivalent gene in S.pneumoniae R6 = spr0464; identified by match to protein family HMM PF02518; histidine kinase BlpH 478043..479383 Streptococcus pneumoniae D39 4442670 YP_815978.1 CDS blpC NC_008533.1 479425 479580 R equivalent gene in S.pneumoniae TIGR4 = SP0528; equivalent gene in S.pneumoniae R6 = spr0465; identified by match to protein family HMM PF08128; match to protein family HMM TIGR01847; peptide pheromone BlpC complement(479425..479580) Streptococcus pneumoniae D39 4441474 YP_815979.1 CDS blpY NC_008533.1 483721 484410 D equivalent gene in S.pneumoniae TIGR4 = SP0545; equivalent gene in S.pneumoniae R6 = spr0472; identified by match to protein family HMM PF02517; immunity protein BlpY 483721..484410 Streptococcus pneumoniae D39 4442591 YP_815980.1 CDS SPD_0474 NC_008533.1 484452 484685 D equivalent gene in S.pneumoniae TIGR4 = SP0546; equivalent gene in S.pneumoniae R6 = spr0473; hypothetical protein 484452..484685 Streptococcus pneumoniae D39 4442373 YP_815981.1 CDS SPD_0475 NC_008533.1 484836 485447 D equivalent gene in S.pneumoniae TIGR4 = SP0547; equivalent gene in S.pneumoniae R6 = spr0474; identified by match to protein family HMM PF02517; CAAX amino terminal protease family protein 484836..485447 Streptococcus pneumoniae D39 4441530 YP_815982.1 CDS SPD_0476 NC_008533.1 485608 486402 D equivalent gene in S.pneumoniae TIGR4 = SP0549; equivalent gene in S.pneumoniae R6 = spr0475; identified by match to protein family HMM PF01636; hypothetical protein 485608..486402 Streptococcus pneumoniae D39 4442049 YP_815983.1 CDS trmB NC_008533.1 486399 487034 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 486399..487034 Streptococcus pneumoniae D39 4442702 YP_815984.1 CDS SPD_0478 NC_008533.1 487160 487639 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 487160..487639 Streptococcus pneumoniae D39 4442456 YP_815985.1 CDS nusA NC_008533.1 487683 488819 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 487683..488819 Streptococcus pneumoniae D39 4441164 YP_815986.1 CDS SPD_0480 NC_008533.1 488841 489134 D equivalent gene in S.pneumoniae TIGR4 = SP0554; equivalent gene in S.pneumoniae R6 = spr0479; identified by match to protein family HMM PF04296; hypothetical protein 488841..489134 Streptococcus pneumoniae D39 4442593 YP_815987.1 CDS SPD_0481 NC_008533.1 489127 489426 D equivalent gene in S.pneumoniae TIGR4 = SP0555; equivalent gene in S.pneumoniae R6 = spr0480; identified by match to protein family HMM PF01248; hypothetical protein 489127..489426 Streptococcus pneumoniae D39 4442260 YP_815988.1 CDS infB NC_008533.1 489443 492235 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 489443..492235 Streptococcus pneumoniae D39 4441217 YP_815989.1 CDS rbfA NC_008533.1 492486 492836 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 492486..492836 Streptococcus pneumoniae D39 4442410 YP_815990.1 CDS SPD_0484 NC_008533.1 493079 493894 D equivalent gene in S.pneumoniae TIGR4 = SP0558; equivalent gene in S.pneumoniae R6 = spr0483; hypothetical protein 493079..493894 Streptococcus pneumoniae D39 4442971 YP_815991.1 CDS SPD_0485 NC_008533.1 493896 494078 D equivalent gene in S.pneumoniae R6 = spr0484; hypothetical protein 493896..494078 Streptococcus pneumoniae D39 4441313 YP_815992.1 CDS SPD_0486 NC_008533.1 494075 494215 D hypothetical protein 494075..494215 Streptococcus pneumoniae D39 4441533 YP_815993.1 CDS SPD_0487 NC_008533.1 494516 494761 D equivalent gene in S.pneumoniae TIGR4 = SP0561; equivalent gene in S.pneumoniae R6 = spr0485; hypothetical protein 494516..494761 Streptococcus pneumoniae D39 4441808 YP_815994.1 CDS SPD_0488 NC_008533.1 494761 496095 D equivalent gene in S.pneumoniae TIGR4 = SP0562; equivalent gene in S.pneumoniae R6 = spr0486; identified by match to protein family HMM PF01814; match to protein family HMM PF04282; hypothetical protein 494761..496095 Streptococcus pneumoniae D39 4442884 YP_815995.1 CDS SPD_0489 NC_008533.1 496105 496359 D equivalent gene in S.pneumoniae TIGR4 = SP0563; equivalent gene in S.pneumoniae R6 = spr0487; hypothetical protein 496105..496359 Streptococcus pneumoniae D39 4442913 YP_815996.1 CDS SPD_0490 NC_008533.1 496455 496850 D equivalent gene in S.pneumoniae TIGR4 = SP0564; equivalent gene in S.pneumoniae R6 = spr0488; hypothetical protein 496455..496850 Streptococcus pneumoniae D39 4441029 YP_815997.1 CDS SPD_0491 NC_008533.1 497262 497711 D equivalent gene in S.pneumoniae TIGR4 = SP0565; equivalent gene in S.pneumoniae R6 = spr0489; hypothetical protein 497262..497711 Streptococcus pneumoniae D39 4442121 YP_815998.1 CDS SPD_0492 NC_008533.1 497698 498255 D equivalent gene in S.pneumoniae R6 = spr0490; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 497698..498255 Streptococcus pneumoniae D39 4441875 YP_815999.1 CDS SPD_0493 NC_008533.1 498257 499219 D equivalent gene in S.pneumoniae R6 = spr0491; hypothetical protein 498257..499219 Streptococcus pneumoniae D39 4442250 YP_816000.1 CDS valS NC_008533.1 499231 501882 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 499231..501882 Streptococcus pneumoniae D39 4442827 YP_816001.1 CDS SPD_0495 NC_008533.1 501952 502707 D equivalent gene in S.pneumoniae R6 = spr0493; hypothetical protein 501952..502707 Streptococcus pneumoniae D39 4442137 YP_816002.1 CDS SPD_0496 NC_008533.1 502990 503793 D equivalent gene in S.pneumoniae TIGR4 = SP0571; equivalent gene in S.pneumoniae R6 = spr0494; identified by match to protein family HMM PF02661; cell filamentation protein Fic-like protein 502990..503793 Streptococcus pneumoniae D39 4441575 YP_816003.1 CDS SPD_0499 NC_008533.1 504947 505159 R equivalent gene in S.pneumoniae TIGR4 = SP1596; equivalent gene in S.pneumoniae R6 = spr0498; hypothetical protein complement(504947..505159) Streptococcus pneumoniae D39 4442967 YP_816004.1 CDS licT NC_008533.1 508402 509241 D equivalent gene in S.pneumoniae TIGR4 = SP0576; equivalent gene in S.pneumoniae R6 = spr0504; identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator Lict 508402..509241 Streptococcus pneumoniae D39 4442201 YP_816005.1 CDS SPD_0502 NC_008533.1 509259 511097 D equivalent gene in S.pneumoniae TIGR4 = SP0577; equivalent gene in S.pneumoniae R6 = spr0505; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995; PTS system beta-glucosides-specific transporter subunit IIABC 509259..511097 Streptococcus pneumoniae D39 4442699 YP_816006.1 CDS bglA-2 NC_008533.1 511110 512525 D equivalent gene in S.pneumoniae TIGR4 = SP0578; equivalent gene in S.pneumoniae R6 = spr0506; identified by match to protein family HMM PF00232; 6-phospho-beta-glucosidase 511110..512525 Streptococcus pneumoniae D39 4441405 YP_816007.1 CDS pheS NC_008533.1 513117 514163 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 513117..514163 Streptococcus pneumoniae D39 4442144 YP_816008.1 CDS SPD_0505 NC_008533.1 514163 514672 D equivalent gene in S.pneumoniae TIGR4 = SP0580; equivalent gene in S.pneumoniae R6 = spr0508; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 514163..514672 Streptococcus pneumoniae D39 4441484 YP_816009.1 CDS pheT NC_008533.1 514749 517151 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 514749..517151 Streptococcus pneumoniae D39 4441915 YP_816010.1 CDS SPD_0507 NC_008533.1 517219 518220 R equivalent gene in S.pneumoniae TIGR4 = SP0582; equivalent gene in S.pneumoniae R6 = spr0510; identified by match to protein family HMM PF03372; hypothetical protein complement(517219..518220) Streptococcus pneumoniae D39 4441494 YP_816011.1 CDS SPD_0509 NC_008533.1 518949 519215 D equivalent gene in S.pneumoniae TIGR4 = SP1144; equivalent gene in S.pneumoniae R6 = spr0513; identified by match to protein family HMM PF01381; hypothetical protein 518949..519215 Streptococcus pneumoniae D39 4441544 YP_816012.1 CDS metE NC_008533.1 519476 521725 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 519476..521725 Streptococcus pneumoniae D39 4442011 YP_816013.1 CDS metF NC_008533.1 521789 522655 D equivalent gene in S.pneumoniae TIGR4 = SP0586; equivalent gene in S.pneumoniae R6 = spr0515; identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; 5,10-methylenetetrahydrofolate reductase 521789..522655 Streptococcus pneumoniae D39 4441222 YP_816014.1 CDS pnp NC_008533.1 523226 525553 D equivalent gene in S.pneumoniae TIGR4 = SP0588; equivalent gene in S.pneumoniae R6 = spr0516; identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase/polyadenylase 523226..525553 Streptococcus pneumoniae D39 4441020 YP_816015.1 CDS cysE NC_008533.1 525569 526186 D equivalent gene in S.pneumoniae TIGR4 = SP0589; equivalent gene in S.pneumoniae R6 = spr0517; identified by match to protein family HMM TIGR01172; serine O-acetyltransferase 525569..526186 Streptococcus pneumoniae D39 4442943 YP_816016.1 CDS SPD_0514 NC_008533.1 526198 527082 D equivalent gene in S.pneumoniae TIGR4 = SP0590; equivalent gene in S.pneumoniae R6 = spr0518; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 526198..527082 Streptococcus pneumoniae D39 4441181 YP_816017.1 CDS cysS NC_008533.1 527164 528507 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 527164..528507 Streptococcus pneumoniae D39 4441826 YP_816018.1 CDS SPD_0516 NC_008533.1 528500 528886 D equivalent gene in S.pneumoniae TIGR4 = SP0592; equivalent gene in S.pneumoniae R6 = spr0520; hypothetical protein 528500..528886 Streptococcus pneumoniae D39 4441171 YP_816019.1 CDS SPD_0517 NC_008533.1 528890 529774 D equivalent gene in S.pneumoniae TIGR4 = SP0593; equivalent gene in S.pneumoniae R6 = spr0521; hypothetical protein 528890..529774 Streptococcus pneumoniae D39 4442102 YP_816020.1 CDS SPD_0518 NC_008533.1 529911 530366 D equivalent gene in S.pneumoniae TIGR4 = SP0595; equivalent gene in S.pneumoniae R6 = spr0522; hypothetical protein 529911..530366 Streptococcus pneumoniae D39 4441154 YP_816021.1 CDS SPD_0519 NC_008533.1 530363 530509 D equivalent gene in S.pneumoniae TIGR4 = SP0596; hypothetical protein 530363..530509 Streptococcus pneumoniae D39 4442848 YP_816022.1 CDS SPD_0520 NC_008533.1 530655 530828 D equivalent gene in S.pneumoniae R6 = spr0523; transposase, , truncation 530655..530828 Streptococcus pneumoniae D39 4441993 YP_816023.1 CDS vex1 NC_008533.1 531180 532457 D equivalent gene in S.pneumoniae TIGR4 = SP0599; equivalent gene in S.pneumoniae R6 = spr0524; identified by match to protein family HMM PF02687; ABC transporter 531180..532457 Streptococcus pneumoniae D39 4441535 YP_816024.1 CDS vex2 NC_008533.1 532470 533117 D equivalent gene in S.pneumoniae TIGR4 = SP0600; equivalent gene in S.pneumoniae R6 = spr0525; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 532470..533117 Streptococcus pneumoniae D39 4442441 YP_816025.1 CDS vex3 NC_008533.1 533169 534548 D equivalent gene in S.pneumoniae TIGR4 = SP0601; equivalent gene in S.pneumoniae R6 = spr0526; identified by match to protein family HMM PF02687; ABC transporter 533169..534548 Streptococcus pneumoniae D39 4442709 YP_816026.1 CDS vncR NC_008533.1 534860 535516 D equivalent gene in S.pneumoniae TIGR4 = SP0603; equivalent gene in S.pneumoniae R6 = spr0528; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator VncR 534860..535516 Streptococcus pneumoniae D39 4443065 YP_816027.1 CDS vncS NC_008533.1 535513 536841 D equivalent gene in S.pneumoniae TIGR4 = SP0604; equivalent gene in S.pneumoniae R6 = spr0529; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase VncS 535513..536841 Streptococcus pneumoniae D39 4441085 YP_816028.1 CDS fba NC_008533.1 536982 537863 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 536982..537863 Streptococcus pneumoniae D39 4441096 YP_816029.1 CDS SPD_0527 NC_008533.1 538184 539374 R equivalent gene in S.pneumoniae TIGR4 = SP0606; equivalent gene in S.pneumoniae R6 = spr0531; identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794; oxidoreductase complement(538184..539374) Streptococcus pneumoniae D39 4442552 YP_816030.1 CDS SPD_0528 NC_008533.1 539632 540291 R equivalent gene in S.pneumoniae TIGR4 = SP0607; equivalent gene in S.pneumoniae R6 = spr0532; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(539632..540291) Streptococcus pneumoniae D39 4442802 YP_816031.1 CDS SPD_0529 NC_008533.1 540301 540978 R equivalent gene in S.pneumoniae TIGR4 = SP0608; equivalent gene in S.pneumoniae R6 = spr0533; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(540301..540978) Streptococcus pneumoniae D39 4442639 YP_816032.1 CDS SPD_0530 NC_008533.1 540991 541785 R equivalent gene in S.pneumoniae TIGR4 = SP0609; equivalent gene in S.pneumoniae R6 = spr0534; identified by match to protein family HMM PF00497; amino acid ABC transporter amino acid-binding protein complement(540991..541785) Streptococcus pneumoniae D39 4443071 YP_816033.1 CDS recJ NC_008533.1 542831 545053 D equivalent gene in S.pneumoniae TIGR4 = SP0611; equivalent gene in S.pneumoniae R6 = spr0537; identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644; single-stranded-DNA-specific exonuclease RecJ 542831..545053 Streptococcus pneumoniae D39 4442381 YP_816034.1 CDS SPD_0533 NC_008533.1 545228 546889 D equivalent gene in S.pneumoniae TIGR4 = SP0613; equivalent gene in S.pneumoniae R6 = spr0538; identified by match to protein family HMM PF00753; match to protein family HMM PF07521; metallo-beta-lactamase superfamily protein 545228..546889 Streptococcus pneumoniae D39 4442678 YP_816035.1 CDS estA NC_008533.1 546958 547737 D equivalent gene in S.pneumoniae TIGR4 = SP0614; equivalent gene in S.pneumoniae R6 = spr0539; identified by match to protein family HMM PF00756; tributyrin esterase 546958..547737 Streptococcus pneumoniae D39 4442559 YP_816036.1 CDS murM/fibA NC_008533.1 547849 549069 D equivalent gene in S.pneumoniae TIGR4 = SP0615; equivalent gene in S.pneumoniae R6 = spr0540; identified by match to protein family HMM PF02388; serine/alanine-adding enzyme MurM 547849..549069 Streptococcus pneumoniae D39 4442661 YP_816037.1 CDS fibB NC_008533.1 549074 550306 D equivalent gene in S.pneumoniae TIGR4 = SP0616; equivalent gene in S.pneumoniae R6 = spr0541; identified by match to protein family HMM PF02388; beta-lactam resistance factor 549074..550306 Streptococcus pneumoniae D39 4441193 YP_816038.1 CDS SPD_0537 NC_008533.1 550422 551081 D equivalent gene in S.pneumoniae TIGR4 = SP0617; equivalent gene in S.pneumoniae R6 = spr0542; identified by match to protein family HMM PF00413; hypothetical protein 550422..551081 Streptococcus pneumoniae D39 4442957 YP_816039.1 CDS uvrC NC_008533.1 551121 552965 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 551121..552965 Streptococcus pneumoniae D39 4441278 YP_816040.1 CDS SPD_0539 NC_008533.1 552955 553788 D equivalent gene in S.pneumoniae TIGR4 = SP0619; equivalent gene in S.pneumoniae R6 = spr0544; identified by match to protein family HMM PF00149; Ser/Thr protein phosphatase family protein 552955..553788 Streptococcus pneumoniae D39 4442524 YP_816041.1 CDS SPD_0540 NC_008533.1 553970 554770 R equivalent gene in S.pneumoniae TIGR4 = SP0620; equivalent gene in S.pneumoniae R6 = spr0545; identified by match to protein family HMM PF00497; amino acid ABC transporter amino acid-binding protein complement(553970..554770) Streptococcus pneumoniae D39 4442369 YP_816042.1 CDS SPD_0541 NC_008533.1 554941 555546 D equivalent gene in S.pneumoniae TIGR4 = SP0622; equivalent gene in S.pneumoniae R6 = spr0546; identified by match to protein family HMM PF00881; nitroreductase family protein 554941..555546 Streptococcus pneumoniae D39 4442048 YP_816043.1 CDS pepV NC_008533.1 555559 556959 D divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 555559..556959 Streptococcus pneumoniae D39 4441681 YP_816044.1 CDS SPD_0543 NC_008533.1 557013 557591 D equivalent gene in S.pneumoniae TIGR4 = SP0624; equivalent gene in S.pneumoniae R6 = spr0548; identified by match to protein family HMM PF03167; hypothetical protein 557013..557591 Streptococcus pneumoniae D39 4441970 YP_816045.1 CDS SPD_0544 NC_008533.1 557755 557907 D equivalent gene in S.pneumoniae R6 = spr0549; hypothetical protein 557755..557907 Streptococcus pneumoniae D39 4441396 YP_816046.1 CDS SPD_0545 NC_008533.1 557908 558042 D equivalent gene in S.pneumoniae R6 = spr0550; hypothetical protein 557908..558042 Streptococcus pneumoniae D39 4442989 YP_816047.1 CDS brnQ NC_008533.1 558213 559538 D equivalent gene in S.pneumoniae TIGR4 = SP0626; equivalent gene in S.pneumoniae R6 = spr0551; identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 558213..559538 Streptococcus pneumoniae D39 4442136 YP_816048.1 CDS SPD_0547 NC_008533.1 559742 560779 D equivalent gene in S.pneumoniae TIGR4 = SP0627; equivalent gene in S.pneumoniae R6 = spr0552; identified by match to protein family HMM PF05343; hypothetical protein 559742..560779 Streptococcus pneumoniae D39 4441600 YP_816049.1 CDS SPD_0548 NC_008533.1 560748 561251 D equivalent gene in S.pneumoniae TIGR4 = SP0628; equivalent gene in S.pneumoniae R6 = spr0553; identified by match to protein family HMM PF01230; HIT family protein 560748..561251 Streptococcus pneumoniae D39 4442731 YP_816050.1 CDS SPD_0549 NC_008533.1 561254 561970 D equivalent gene in S.pneumoniae TIGR4 = SP0629; equivalent gene in S.pneumoniae R6 = spr0554; identified by match to protein family HMM PF02557; hypothetical protein 561254..561970 Streptococcus pneumoniae D39 4441275 YP_816051.1 CDS rplK NC_008533.1 562279 562704 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 562279..562704 Streptococcus pneumoniae D39 4442253 YP_816052.1 CDS rplA NC_008533.1 562912 563601 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 562912..563601 Streptococcus pneumoniae D39 4441446 YP_816053.1 CDS SPD_0552 NC_008533.1 564193 564780 R hypothetical protein complement(564193..564780) Streptococcus pneumoniae D39 4441128 YP_816054.1 CDS SPD_0553 NC_008533.1 564746 565075 D equivalent gene in S.pneumoniae TIGR4 = SP0633; hypothetical protein 564746..565075 Streptococcus pneumoniae D39 4441976 YP_816055.1 CDS SPD_0554 NC_008533.1 566119 567111 D equivalent gene in S.pneumoniae TIGR4 = SP0636; equivalent gene in S.pneumoniae R6 = spr0557; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 566119..567111 Streptococcus pneumoniae D39 4441697 YP_816056.1 CDS SPD_0555 NC_008533.1 567113 567931 D equivalent gene in S.pneumoniae TIGR4 = SP0637; equivalent gene in S.pneumoniae R6 = spr0558; identified by match to protein family HMM PF06182; hypothetical protein 567113..567931 Streptococcus pneumoniae D39 4441774 YP_816057.1 CDS SPD_0556 NC_008533.1 567933 568718 D equivalent gene in S.pneumoniae TIGR4 = SP0638; equivalent gene in S.pneumoniae R6 = spr0559; identified by match to protein family HMM PF06182; hypothetical protein 567933..568718 Streptococcus pneumoniae D39 4442053 YP_816058.1 CDS prtA NC_008533.1 569948 576382 D equivalent gene in S.pneumoniae TIGR4 = SP0641; equivalent gene in S.pneumoniae R6 = spr0561; identified by match to protein family HMM PF00082; match to protein family HMM PF00746; match to protein family HMM PF02225; match to protein family HMM PF06280; match to protein family HMM TIGR01167; cell wall-associated serine protease PrtA 569948..576382 Streptococcus pneumoniae D39 4442925 YP_816059.1 CDS SPD_0559 NC_008533.1 577007 577483 D equivalent gene in S.pneumoniae TIGR4 = SP0645; equivalent gene in S.pneumoniae R6 = spr0562; identified by match to protein family HMM PF00359; PTS system transporter subunit IIA 577007..577483 Streptococcus pneumoniae D39 4442507 YP_816060.1 CDS SPD_0560 NC_008533.1 577521 577826 D equivalent gene in S.pneumoniae TIGR4 = SP0646; equivalent gene in S.pneumoniae R6 = spr0563; PTS system transporter subunit IIB 577521..577826 Streptococcus pneumoniae D39 4442510 YP_816061.1 CDS SPD_0561 NC_008533.1 577874 579349 D equivalent gene in S.pneumoniae TIGR4 = SP0647; equivalent gene in S.pneumoniae R6 = spr0564; identified by match to protein family HMM PF03611; PTS system transporter subunit IIC 577874..579349 Streptococcus pneumoniae D39 4441821 YP_816062.1 CDS bgaA NC_008533.1 579654 586340 D equivalent gene in S.pneumoniae TIGR4 = SP0648; equivalent gene in S.pneumoniae R6 = spr0565; identified by match to protein family HMM PF00703; match to protein family HMM PF00746; match to protein family HMM PF02836; match to protein family HMM PF02837; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07532; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-galactosidase 579654..586340 Streptococcus pneumoniae D39 4442642 YP_816063.1 CDS SPD_0564 NC_008533.1 587654 588007 R equivalent gene in S.pneumoniae TIGR4 = SP0650; equivalent gene in S.pneumoniae R6 = spr0568; hypothetical protein complement(587654..588007) Streptococcus pneumoniae D39 4442800 YP_816064.1 CDS SPD_0565 NC_008533.1 588105 588557 D equivalent gene in S.pneumoniae R6 = spr0569; hypothetical protein 588105..588557 Streptococcus pneumoniae D39 4443001 YP_816065.1 CDS SPD_0566 NC_008533.1 588615 589061 D equivalent gene in S.pneumoniae R6 = spr0570; hypothetical protein 588615..589061 Streptococcus pneumoniae D39 4441937 YP_816066.1 CDS SPD_0567 NC_008533.1 589039 589602 D equivalent gene in S.pneumoniae TIGR4 = SP0652; equivalent gene in S.pneumoniae R6 = spr0571; identified by match to protein family HMM PF06962; hypothetical protein 589039..589602 Streptococcus pneumoniae D39 4441762 YP_816067.1 CDS SPD_0568 NC_008533.1 589595 589849 D equivalent gene in S.pneumoniae TIGR4 = SP0653; equivalent gene in S.pneumoniae R6 = spr0572; hypothetical protein 589595..589849 Streptococcus pneumoniae D39 4441779 YP_816068.1 CDS SPD_0569 NC_008533.1 589861 591915 D equivalent gene in S.pneumoniae TIGR4 = SP0655; equivalent gene in S.pneumoniae R6 = spr0573; identified by match to protein family HMM PF00999; sodium/hydrogen exchanger family protein 589861..591915 Streptococcus pneumoniae D39 4442155 YP_816069.1 CDS SPD_0570 NC_008533.1 592094 592954 D equivalent gene in S.pneumoniae TIGR4 = SP0657; equivalent gene in S.pneumoniae R6 = spr0574; identified by match to protein family HMM PF03631; ribonuclease BN 592094..592954 Streptococcus pneumoniae D39 4441268 YP_816070.1 CDS ccdA-1 NC_008533.1 593165 593875 D equivalent gene in S.pneumoniae TIGR4 = SP0658; equivalent gene in S.pneumoniae R6 = spr0575; identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 593165..593875 Streptococcus pneumoniae D39 4441449 YP_816071.1 CDS SPD_0572 NC_008533.1 593895 594461 D equivalent gene in S.pneumoniae TIGR4 = SP0659; equivalent gene in S.pneumoniae R6 = spr0576; thioredoxin family protein 593895..594461 Streptococcus pneumoniae D39 4441952 YP_816072.1 CDS msrAB2 NC_008533.1 594649 595584 D equivalent gene in S.pneumoniae TIGR4 = SP0660; equivalent gene in S.pneumoniae R6 = spr0577; identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; bifunctional methionine sulfoxide reductase A/B 594649..595584 Streptococcus pneumoniae D39 4442739 YP_816073.1 CDS SPD_0574 NC_008533.1 595852 596589 D equivalent gene in S.pneumoniae TIGR4 = SP0661; equivalent gene in S.pneumoniae R6 = spr0578; identified by match to protein family HMM PF00072; match to protein family HMM PF00165; DNA-binding response regulator 595852..596589 Streptococcus pneumoniae D39 4441596 YP_816074.1 CDS SPD_0575 NC_008533.1 596586 598277 D equivalent gene in S.pneumoniae TIGR4 = SP0662; equivalent gene in S.pneumoniae R6 = spr0579; identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743; match to protein family HMM PF06580; sensor histidine kinase 596586..598277 Streptococcus pneumoniae D39 4442636 YP_816075.1 CDS SPD_0576 NC_008533.1 598393 598956 D equivalent gene in S.pneumoniae TIGR4 = SP0663; equivalent gene in S.pneumoniae R6 = spr0580; identified by match to protein family HMM PF04260; match to protein family HMM TIGR01440; hypothetical protein 598393..598956 Streptococcus pneumoniae D39 4441415 YP_816076.1 CDS zmpB NC_008533.1 598978 604608 D equivalent gene in S.pneumoniae R6 = spr0581; identified by match to protein family HMM PF00746; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpB 598978..604608 Streptococcus pneumoniae D39 4441680 YP_816077.1 CDS pabB NC_008533.1 604678 606399 D equivalent gene in S.pneumoniae TIGR4 = SP0665; equivalent gene in S.pneumoniae R6 = spr0582; identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553; para-aminobenzoate synthase, component I 604678..606399 Streptococcus pneumoniae D39 4442198 YP_816078.1 CDS SPD_0579 NC_008533.1 606557 607546 D equivalent gene in S.pneumoniae TIGR4 = SP0667; equivalent gene in S.pneumoniae R6 = spr0583; identified by match to protein family HMM PF01473; match to protein family HMM PF05901; match to protein family HMM PF07553; surface protein 606557..607546 Streptococcus pneumoniae D39 4441414 YP_816079.1 CDS gki NC_008533.1 607682 608641 D equivalent gene in S.pneumoniae TIGR4 = SP0668; equivalent gene in S.pneumoniae R6 = spr0584; identified by match to protein family HMM PF00480; match to protein family HMM TIGR00744; glucokinase 607682..608641 Streptococcus pneumoniae D39 4441973 YP_816080.1 CDS thyA NC_008533.1 608738 609577 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 608738..609577 Streptococcus pneumoniae D39 4441151 YP_816081.1 CDS SPD_0582 NC_008533.1 609625 609795 R equivalent gene in S.pneumoniae TIGR4 = SP0670; equivalent gene in S.pneumoniae R6 = spr0586; hypothetical protein complement(609625..609795) Streptococcus pneumoniae D39 4442767 YP_816082.1 CDS miaA NC_008533.1 609916 610800 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 609916..610800 Streptococcus pneumoniae D39 4441153 YP_816083.1 CDS hflX NC_008533.1 610793 612031 D equivalent gene in S.pneumoniae TIGR4 = SP0672; equivalent gene in S.pneumoniae R6 = spr0589; identified by match to protein family HMM PF01926; match to protein family HMM TIGR00231; GTP-binding protein HflX 610793..612031 Streptococcus pneumoniae D39 4441926 YP_816084.1 CDS SPD_0585 NC_008533.1 612024 612647 D equivalent gene in S.pneumoniae TIGR4 = SP0673; equivalent gene in S.pneumoniae R6 = spr0590; hypothetical protein 612024..612647 Streptococcus pneumoniae D39 4442135 YP_816085.1 CDS rnz NC_008533.1 612662 613591 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 612662..613591 Streptococcus pneumoniae D39 4442325 YP_816086.1 CDS SPD_0587 NC_008533.1 613612 614367 D equivalent gene in S.pneumoniae TIGR4 = SP0675; equivalent gene in S.pneumoniae R6 = spr0592; identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase family oxidoreductase 613612..614367 Streptococcus pneumoniae D39 4442431 YP_816087.1 CDS SPD_0588 NC_008533.1 614421 615389 R equivalent gene in S.pneumoniae TIGR4 = SP0676; equivalent gene in S.pneumoniae R6 = spr0593; identified by match to protein family HMM PF00126; transcriptional regulator complement(614421..615389) Streptococcus pneumoniae D39 4441907 YP_816088.1 CDS SPD_0589 NC_008533.1 615393 615662 D equivalent gene in S.pneumoniae TIGR4 = SP0677; equivalent gene in S.pneumoniae R6 = spr0594; identified by match to protein family HMM PF06014; hypothetical protein 615393..615662 Streptococcus pneumoniae D39 4441652 YP_816089.1 CDS SPD_0590 NC_008533.1 615662 616042 D equivalent gene in S.pneumoniae TIGR4 = SP0678; equivalent gene in S.pneumoniae R6 = spr0595; identified by match to protein family HMM PF00581; rhodanese-like domain-containing protein 615662..616042 Streptococcus pneumoniae D39 4442891 YP_816090.1 CDS SPD_0591 NC_008533.1 616161 616358 D equivalent gene in S.pneumoniae TIGR4 = SP0679; equivalent gene in S.pneumoniae R6 = spr0596; hypothetical protein 616161..616358 Streptococcus pneumoniae D39 4441939 YP_816091.1 CDS rsuA-2 NC_008533.1 616398 617123 R equivalent gene in S.pneumoniae TIGR4 = SP0680; equivalent gene in S.pneumoniae R6 = spr0597; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A complement(616398..617123) Streptococcus pneumoniae D39 4441486 YP_816092.1 CDS SPD_0593 NC_008533.1 617285 619126 D equivalent gene in S.pneumoniae TIGR4 = SP0681; equivalent gene in S.pneumoniae R6 = spr0598; identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; elongation factor Tu family protein 617285..619126 Streptococcus pneumoniae D39 4441272 YP_816093.1 CDS SPD_0594 NC_008533.1 619146 619400 D equivalent gene in S.pneumoniae TIGR4 = SP0682; equivalent gene in S.pneumoniae R6 = spr0599; hypothetical protein 619146..619400 Streptococcus pneumoniae D39 4442645 YP_816094.1 CDS SPD_0595 NC_008533.1 619716 620063 D equivalent gene in S.pneumoniae R6 = spr0600; identified by match to protein family HMM TIGR01653; hypothetical protein 619716..620063 Streptococcus pneumoniae D39 4442595 YP_816095.1 CDS SPD_0596 NC_008533.1 620134 622155 D equivalent gene in S.pneumoniae TIGR4 = SP0686; equivalent gene in S.pneumoniae R6 = spr0601; identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; hypothetical protein 620134..622155 Streptococcus pneumoniae D39 4441277 YP_816096.1 CDS SPD_0597 NC_008533.1 622157 622798 D equivalent gene in S.pneumoniae TIGR4 = SP0687; equivalent gene in S.pneumoniae R6 = spr0602; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 622157..622798 Streptococcus pneumoniae D39 4441041 YP_816097.1 CDS murD NC_008533.1 622902 624254 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 622902..624254 Streptococcus pneumoniae D39 4442418 YP_816098.1 CDS murG NC_008533.1 624258 625316 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 624258..625316 Streptococcus pneumoniae D39 4442422 YP_816099.1 CDS divIB NC_008533.1 625326 626516 D equivalent gene in S.pneumoniae TIGR4 = SP0690; equivalent gene in S.pneumoniae R6 = spr0605; identified by match to protein family HMM PF03799; cell division protein DivIB 625326..626516 Streptococcus pneumoniae D39 4442355 YP_816100.1 CDS SPD_0601 NC_008533.1 626647 626772 D equivalent gene in S.pneumoniae TIGR4 = SP0691; identified by Glimmer2; hypothetical protein 626647..626772 Streptococcus pneumoniae D39 4442948 YP_816101.1 CDS SPD_0602 NC_008533.1 626784 626915 D equivalent gene in S.pneumoniae TIGR4 = SP0692; hypothetical protein 626784..626915 Streptococcus pneumoniae D39 4442729 YP_816102.1 CDS SPD_0603 NC_008533.1 627307 628104 D equivalent gene in S.pneumoniae TIGR4 = SP0694; equivalent gene in S.pneumoniae R6 = spr0607; identified by match to protein family HMM PF02163; hypothetical protein 627307..628104 Streptococcus pneumoniae D39 4441892 YP_816103.1 CDS SPD_0604 NC_008533.1 628447 629460 D equivalent gene in S.pneumoniae TIGR4 = SP0695; equivalent gene in S.pneumoniae R6 = spr0608; identified by match to protein family HMM PF00899; HesA/MoeB/ThiF family protein 628447..629460 Streptococcus pneumoniae D39 4442761 YP_816104.1 CDS SPD_0606 NC_008533.1 630496 631209 D equivalent gene in S.pneumoniae TIGR4 = SP0698; equivalent gene in S.pneumoniae R6 = spr0611; identified by match to protein family HMM PF01061; hypothetical protein 630496..631209 Streptococcus pneumoniae D39 4441532 YP_816105.1 CDS pyrF NC_008533.1 631944 632645 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 631944..632645 Streptococcus pneumoniae D39 4442951 YP_816106.1 CDS pyrE NC_008533.1 632679 633311 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 632679..633311 Streptococcus pneumoniae D39 4442899 YP_816107.1 CDS SPD_0610 NC_008533.1 633491 633895 D equivalent gene in S.pneumoniae TIGR4 = SP0703; equivalent gene in S.pneumoniae R6 = spr0615; hypothetical protein 633491..633895 Streptococcus pneumoniae D39 4442519 YP_816108.1 CDS SPD_0611 NC_008533.1 633991 634755 D equivalent gene in S.pneumoniae TIGR4 = SP0704; equivalent gene in S.pneumoniae R6 = spr0616; hypothetical protein 633991..634755 Streptococcus pneumoniae D39 4441789 YP_816109.1 CDS SPD_0612 NC_008533.1 634755 635507 D equivalent gene in S.pneumoniae TIGR4 = SP0705; equivalent gene in S.pneumoniae R6 = spr0617; hypothetical protein 634755..635507 Streptococcus pneumoniae D39 4441969 YP_816110.1 CDS SPD_0613 NC_008533.1 635511 636215 D equivalent gene in S.pneumoniae TIGR4 = SP0706; equivalent gene in S.pneumoniae R6 = spr0618; hypothetical protein 635511..636215 Streptococcus pneumoniae D39 4441395 YP_816111.1 CDS SPD_0614 NC_008533.1 636212 636859 D equivalent gene in S.pneumoniae TIGR4 = SP0707; equivalent gene in S.pneumoniae R6 = spr0619; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 636212..636859 Streptococcus pneumoniae D39 4441589 YP_816112.1 CDS SPD_0616 NC_008533.1 637816 638574 R equivalent gene in S.pneumoniae TIGR4 = SP0709; equivalent gene in S.pneumoniae R6 = spr0622; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein complement(637816..638574) Streptococcus pneumoniae D39 4441152 YP_816113.1 CDS SPD_0617 NC_008533.1 638575 639252 R equivalent gene in S.pneumoniae TIGR4 = SP0710; equivalent gene in S.pneumoniae R6 = spr0623; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(638575..639252) Streptococcus pneumoniae D39 4441577 YP_816114.1 CDS SPD_0618 NC_008533.1 639212 639892 R equivalent gene in S.pneumoniae TIGR4 = SP0711; equivalent gene in S.pneumoniae R6 = spr0624; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(639212..639892) Streptococcus pneumoniae D39 4442394 YP_816115.1 CDS SPD_0619 NC_008533.1 640107 640253 D equivalent gene in S.pneumoniae TIGR4 = SP0712; equivalent gene in S.pneumoniae R6 = spr0625; hypothetical protein 640107..640253 Streptococcus pneumoniae D39 4442852 YP_816116.1 CDS lysS NC_008533.1 640381 641871 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 640381..641871 Streptococcus pneumoniae D39 4441901 YP_816117.1 CDS lctO NC_008533.1 642496 643632 D equivalent gene in S.pneumoniae TIGR4 = SP0715; equivalent gene in S.pneumoniae R6 = spr0627; identified by match to protein family HMM PF01070; match to protein family HMM TIGR02708; lactate oxidase 642496..643632 Streptococcus pneumoniae D39 4441863 YP_816118.1 CDS SPD_0622 NC_008533.1 644187 644855 D equivalent gene in S.pneumoniae TIGR4 = SP0716; equivalent gene in S.pneumoniae R6 = spr0628; identified by match to protein family HMM PF03070; transcriptional regulator, TENA/THI-4 family protein 644187..644855 Streptococcus pneumoniae D39 4442594 YP_816119.1 CDS thiM NC_008533.1 645144 645926 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 645144..645926 Streptococcus pneumoniae D39 4441244 YP_816120.1 CDS thiE-1 NC_008533.1 645928 646557 D equivalent gene in S.pneumoniae TIGR4 = SP0718; equivalent gene in S.pneumoniae R6 = spr0630; identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693; thiamine-phosphate pyrophosphorylase 645928..646557 Streptococcus pneumoniae D39 4441039 YP_816121.1 CDS SPD_0625 NC_008533.1 647115 647675 D equivalent gene in S.pneumoniae TIGR4 = SP0719; equivalent gene in S.pneumoniae R6 = spr0631; hypothetical protein 647115..647675 Streptococcus pneumoniae D39 4442536 YP_816122.1 CDS SPD_0626 NC_008533.1 647676 649061 D equivalent gene in S.pneumoniae TIGR4 = SP0720; equivalent gene in S.pneumoniae R6 = spr0632; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 647676..649061 Streptococcus pneumoniae D39 4442239 YP_816123.1 CDS SPD_0627 NC_008533.1 649063 649713 D equivalent gene in S.pneumoniae TIGR4 = SP0721; equivalent gene in S.pneumoniae R6 = spr0633; hypothetical protein 649063..649713 Streptococcus pneumoniae D39 4442812 YP_816124.1 CDS tenA NC_008533.1 649724 650416 D equivalent gene in S.pneumoniae TIGR4 = SP0722; equivalent gene in S.pneumoniae R6 = spr0634; identified by match to protein family HMM PF03070; transcriptional activator TenA, TENA/THI-4 family protein 649724..650416 Streptococcus pneumoniae D39 4441885 YP_816125.1 CDS thiW NC_008533.1 650421 650945 D equivalent gene in S.pneumoniae TIGR4 = SP0723; equivalent gene in S.pneumoniae R6 = spr0635; identified by match to protein family HMM TIGR02359; hypothetical protein 650421..650945 Streptococcus pneumoniae D39 4442330 YP_816126.1 CDS SPD_0630 NC_008533.1 650945 651748 D equivalent gene in S.pneumoniae TIGR4 = SP0724; equivalent gene in S.pneumoniae R6 = spr0636; identified by match to protein family HMM PF02110; hydroxyethylthiazole kinase 650945..651748 Streptococcus pneumoniae D39 4441237 YP_816127.1 CDS thiE NC_008533.1 651741 652373 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 651741..652373 Streptococcus pneumoniae D39 4441329 YP_816128.1 CDS thiD NC_008533.1 652582 653373 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(652582..653373) Streptococcus pneumoniae D39 4441258 YP_816129.1 CDS SPD_0633 NC_008533.1 653739 654134 D equivalent gene in S.pneumoniae TIGR4 = SP0727; equivalent gene in S.pneumoniae R6 = spr0639; identified by match to protein family HMM PF03965; match to protein family HMM TIGR02698; transcriptional regulator 653739..654134 Streptococcus pneumoniae D39 4442646 YP_816130.1 CDS SPD_0634 NC_008533.1 654145 654516 D equivalent gene in S.pneumoniae TIGR4 = SP0728; equivalent gene in S.pneumoniae R6 = spr0640; hypothetical protein 654145..654516 Streptococcus pneumoniae D39 4442810 YP_816131.1 CDS SPD_0635 NC_008533.1 654526 656769 D equivalent gene in S.pneumoniae TIGR4 = SP0729; equivalent gene in S.pneumoniae R6 = spr0641; identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; cation-transporting ATPase, E1-E2 family protein 654526..656769 Streptococcus pneumoniae D39 4441853 YP_816132.1 CDS spxB NC_008533.1 656976 658751 D equivalent gene in S.pneumoniae TIGR4 = SP0730; equivalent gene in S.pneumoniae R6 = spr0642; identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720; pyruvate oxidase 656976..658751 Streptococcus pneumoniae D39 4441644 YP_816133.1 CDS SPD_0637 NC_008533.1 658862 659209 D equivalent gene in S.pneumoniae TIGR4 = SP0731; equivalent gene in S.pneumoniae R6 = spr0643; identified by match to protein family HMM PF00903; hypothetical protein 658862..659209 Streptococcus pneumoniae D39 4441928 YP_816134.1 CDS SPD_0638 NC_008533.1 659326 659979 R equivalent gene in S.pneumoniae TIGR4 = SP0811; equivalent gene in S.pneumoniae R6 = spr0644; transposase family protein complement(659326..659979) Streptococcus pneumoniae D39 4441462 YP_816135.1 CDS SPD_0639 NC_008533.1 659867 660214 R equivalent gene in S.pneumoniae TIGR4 = SP1487; equivalent gene in S.pneumoniae R6 = spr0645; hypothetical protein complement(659867..660214) Streptococcus pneumoniae D39 4442231 YP_816136.1 CDS manA NC_008533.1 661064 662008 D equivalent gene in S.pneumoniae TIGR4 = SP0736; equivalent gene in S.pneumoniae R6 = spr0647; identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase 661064..662008 Streptococcus pneumoniae D39 4442605 YP_816137.1 CDS SPD_0642 NC_008533.1 662111 663496 R This gene may encode a frameshift. The COOH end is frameshifted relative to the TIGR4 ortholog. equivalent gene in S.pneumoniae TIGR4 = SP0737; equivalent gene in S.pneumoniae R6 = spr0648; identified by match to protein family HMM PF00209; sodium-dependent transporter complement(662111..663496) Streptococcus pneumoniae D39 4442493 YP_816138.1 CDS SPD_0644 NC_008533.1 664353 664808 R equivalent gene in S.pneumoniae TIGR4 = SP0740; equivalent gene in S.pneumoniae R6 = spr0650; identified by match to protein family HMM PF00293; MutT/nudix family protein complement(664353..664808) Streptococcus pneumoniae D39 4441301 YP_816139.1 CDS SPD_0645 NC_008533.1 664828 666003 R equivalent gene in S.pneumoniae TIGR4 = SP0741; equivalent gene in S.pneumoniae R6 = spr0651; identified by match to protein family HMM PF03486; match to protein family HMM TIGR00275; hypothetical protein complement(664828..666003) Streptococcus pneumoniae D39 4442124 YP_816140.1 CDS SPD_0646 NC_008533.1 666062 666907 R equivalent gene in S.pneumoniae TIGR4 = SP0742; equivalent gene in S.pneumoniae R6 = spr0652; identified by match to protein family HMM PF02645; hypothetical protein complement(666062..666907) Streptococcus pneumoniae D39 4442089 YP_816141.1 CDS SPD_0647 NC_008533.1 667032 667589 D equivalent gene in S.pneumoniae TIGR4 = SP0743; equivalent gene in S.pneumoniae R6 = spr0653; identified by match to protein family HMM PF00440; transcriptional regulator, TetR family protein 667032..667589 Streptococcus pneumoniae D39 4442358 YP_816142.1 CDS SPD_0648 NC_008533.1 667608 668075 D equivalent gene in S.pneumoniae TIGR4 = SP0744; equivalent gene in S.pneumoniae R6 = spr0654; identified by match to protein family HMM PF00383; cytidine and deoxycytidylate deaminase family protein 667608..668075 Streptococcus pneumoniae D39 4441061 YP_816143.1 CDS upp NC_008533.1 668143 668793 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 668143..668793 Streptococcus pneumoniae D39 4441158 YP_816144.1 CDS clpP NC_008533.1 668967 669557 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 668967..669557 Streptococcus pneumoniae D39 4441476 YP_816145.1 CDS SPD_0651 NC_008533.1 669636 669884 D equivalent gene in S.pneumoniae TIGR4 = SP0748; equivalent gene in S.pneumoniae R6 = spr0657; hypothetical protein 669636..669884 Streptococcus pneumoniae D39 4441420 YP_816146.1 CDS livJ NC_008533.1 669986 671146 D equivalent gene in S.pneumoniae TIGR4 = SP0749; equivalent gene in S.pneumoniae R6 = spr0659; identified by match to protein family HMM PF01094; branched-chain amino acid ABC transporter substrate-binding protein 669986..671146 Streptococcus pneumoniae D39 4442411 YP_816147.1 CDS livH NC_008533.1 671414 672283 D equivalent gene in S.pneumoniae TIGR4 = SP0750; equivalent gene in S.pneumoniae R6 = spr0660; identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 671414..672283 Streptococcus pneumoniae D39 4442669 YP_816148.1 CDS livM NC_008533.1 672287 673243 D equivalent gene in S.pneumoniae TIGR4 = SP0751; equivalent gene in S.pneumoniae R6 = spr0661; identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 672287..673243 Streptococcus pneumoniae D39 4441428 YP_816149.1 CDS livG NC_008533.1 673243 674007 D equivalent gene in S.pneumoniae TIGR4 = SP0752; equivalent gene in S.pneumoniae R6 = spr0662; identified by match to protein family HMM PF00005; branched-chain amino acid ABC transporter ATP-binding protein 673243..674007 Streptococcus pneumoniae D39 4441516 YP_816150.1 CDS livF NC_008533.1 674007 674717 D equivalent gene in S.pneumoniae TIGR4 = SP0753; equivalent gene in S.pneumoniae R6 = spr0663; identified by match to protein family HMM PF00005; branched-chain amino acid ABC transporter ATP-binding protein 674007..674717 Streptococcus pneumoniae D39 4442558 YP_816151.1 CDS SPD_0657 NC_008533.1 675131 675787 D equivalent gene in S.pneumoniae TIGR4 = SP0754; equivalent gene in S.pneumoniae R6 = spr0664; identified by match to protein family HMM PF00571; match to protein family HMM PF01842; acetoin utilization protein AcuB 675131..675787 Streptococcus pneumoniae D39 4442148 YP_816152.1 CDS prfB NC_008533.1 676001 676990 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 676001..676990 Streptococcus pneumoniae D39 4442600 YP_816153.1 CDS ftsE NC_008533.1 677008 677700 D equivalent gene in S.pneumoniae TIGR4 = SP0756; equivalent gene in S.pneumoniae R6 = spr0666; identified by match to protein family HMM PF00005; match to protein family HMM TIGR02673; cell division ATP-binding protein FtsE 677008..677700 Streptococcus pneumoniae D39 4442409 YP_816154.1 CDS ftsX NC_008533.1 677693 678619 D equivalent gene in S.pneumoniae TIGR4 = SP0757; equivalent gene in S.pneumoniae R6 = spr0667; identified by match to protein family HMM PF02687; cell division ABC transporter permease FtsX 677693..678619 Streptococcus pneumoniae D39 4441413 YP_816155.1 CDS exp5 NC_008533.1 678905 681085 D equivalent gene in S.pneumoniae TIGR4 = SP0758; equivalent gene in S.pneumoniae R6 = spr0668; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003; PTS system transporter subunit IIABC 678905..681085 Streptococcus pneumoniae D39 4441868 YP_816156.1 CDS SPD_0662 NC_008533.1 681137 681952 D equivalent gene in S.pneumoniae TIGR4 = SP0760; equivalent gene in S.pneumoniae R6 = spr0669; identified by match to protein family HMM PF03372; hypothetical protein 681137..681952 Streptococcus pneumoniae D39 4442527 YP_816157.1 CDS SPD_0663 NC_008533.1 682092 683435 D equivalent gene in S.pneumoniae TIGR4 = SP0761; equivalent gene in S.pneumoniae R6 = spr0670; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 682092..683435 Streptococcus pneumoniae D39 4442073 YP_816158.1 CDS metK NC_008533.1 683650 684840 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 683650..684840 Streptococcus pneumoniae D39 4442877 YP_816159.1 CDS pyrDa NC_008533.1 685393 686328 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 685393..686328 Streptococcus pneumoniae D39 4441361 YP_816160.1 CDS holA NC_008533.1 686362 687399 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 686362..687399 Streptococcus pneumoniae D39 4441076 YP_816161.1 CDS sodA NC_008533.1 687572 688177 D equivalent gene in S.pneumoniae TIGR4 = SP0766; equivalent gene in S.pneumoniae R6 = spr0674; identified by match to protein family HMM PF00081; match to protein family HMM PF02777; superoxide dismutase, manganese-dependent 687572..688177 Streptococcus pneumoniae D39 4442721 YP_816162.1 CDS SPD_0668 NC_008533.1 688334 688864 D equivalent gene in S.pneumoniae TIGR4 = SP0767; equivalent gene in S.pneumoniae R6 = spr0675; identified by match to protein family HMM PF06265; hypothetical protein 688334..688864 Streptococcus pneumoniae D39 4441769 YP_816163.1 CDS SPD_0669 NC_008533.1 688885 689970 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 688885..689970 Streptococcus pneumoniae D39 4442149 YP_816164.1 CDS SPD_0670 NC_008533.1 690008 690439 D equivalent gene in S.pneumoniae R6 = spr0677; identified by match to protein family HMM PF04892; hypothetical protein 690008..690439 Streptococcus pneumoniae D39 4441491 YP_816165.1 CDS SPD_0671 NC_008533.1 690441 691982 D equivalent gene in S.pneumoniae TIGR4 = SP0770; equivalent gene in S.pneumoniae R6 = spr0678; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 690441..691982 Streptococcus pneumoniae D39 4442226 YP_816166.1 CDS SPD_0672 NC_008533.1 692039 692842 R equivalent gene in S.pneumoniae TIGR4 = SP0771; equivalent gene in S.pneumoniae R6 = spr0679; identified by match to protein family HMM PF00160; cyclophilin type peptidyl-prolyl cis-trans isomerase complement(692039..692842) Streptococcus pneumoniae D39 4442012 YP_816167.1 CDS SPD_0673 NC_008533.1 692926 693147 R equivalent gene in S.pneumoniae TIGR4 = SP0772; equivalent gene in S.pneumoniae R6 = spr0680; hypothetical protein complement(692926..693147) Streptococcus pneumoniae D39 4442116 YP_816168.1 CDS rpsP NC_008533.1 694013 694285 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 694013..694285 Streptococcus pneumoniae D39 4441689 YP_816169.1 CDS SPD_0675 NC_008533.1 694305 694544 D equivalent gene in S.pneumoniae TIGR4 = SP0776; equivalent gene in S.pneumoniae R6 = spr0683; hypothetical protein 694305..694544 Streptococcus pneumoniae D39 4442742 YP_816170.1 CDS SPD_0676 NC_008533.1 695121 695549 D equivalent gene in S.pneumoniae TIGR4 = SP0777; equivalent gene in S.pneumoniae R6 = spr0684; hypothetical protein 695121..695549 Streptococcus pneumoniae D39 4441365 YP_816171.1 CDS SPD_0677 NC_008533.1 695550 695909 D equivalent gene in S.pneumoniae TIGR4 = SP0777; equivalent gene in S.pneumoniae R6 = spr0685; hypothetical protein 695550..695909 Streptococcus pneumoniae D39 4443028 YP_816172.1 CDS rimM NC_008533.1 695940 696458 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 695940..696458 Streptococcus pneumoniae D39 4441529 YP_816173.1 CDS trmD NC_008533.1 696448 697167 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 696448..697167 Streptococcus pneumoniae D39 4442080 YP_816174.1 CDS SPD_0680 NC_008533.1 697179 697517 D equivalent gene in S.pneumoniae TIGR4 = SP0780; equivalent gene in S.pneumoniae R6 = spr0688; identified by match to protein family HMM PF03477; hypothetical protein 697179..697517 Streptococcus pneumoniae D39 4441560 YP_816175.1 CDS SPD_0681 NC_008533.1 697548 697868 R equivalent gene in S.pneumoniae TIGR4 = SP0781; equivalent gene in S.pneumoniae R6 = spr0689; hypothetical protein complement(697548..697868) Streptococcus pneumoniae D39 4442179 YP_816176.1 CDS SPD_0683 NC_008533.1 697966 698181 D equivalent gene in S.pneumoniae TIGR4 = SP0782; equivalent gene in S.pneumoniae R6 = spr0690; hypothetical protein 697966..698181 Streptococcus pneumoniae D39 4442362 YP_816177.1 CDS SPD_0682 NC_008533.1 698178 698324 R hypothetical protein complement(698178..698324) Streptococcus pneumoniae D39 4442612 YP_816178.1 CDS SPD_0684 NC_008533.1 698385 698921 R equivalent gene in S.pneumoniae TIGR4 = SP0783; equivalent gene in S.pneumoniae R6 = spr0691; identified by match to protein family HMM PF02632; biotin synthase complement(698385..698921) Streptococcus pneumoniae D39 4441276 YP_816179.1 CDS gor NC_008533.1 699118 700464 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(699118..700464) Streptococcus pneumoniae D39 4442342 YP_816180.1 CDS SPD_0686 NC_008533.1 700729 701928 D equivalent gene in S.pneumoniae TIGR4 = SP0785; equivalent gene in S.pneumoniae R6 = spr0693; identified by match to protein family HMM TIGR01730; hypothetical protein 700729..701928 Streptococcus pneumoniae D39 4442248 YP_816181.1 CDS SPD_0687 NC_008533.1 701912 702613 D equivalent gene in S.pneumoniae TIGR4 = SP0786; equivalent gene in S.pneumoniae R6 = spr0694; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 701912..702613 Streptococcus pneumoniae D39 4442437 YP_816182.1 CDS SPD_0688 NC_008533.1 702615 703874 D equivalent gene in S.pneumoniae TIGR4 = SP0787; equivalent gene in S.pneumoniae R6 = spr0695; identified by match to protein family HMM PF02687; hypothetical protein 702615..703874 Streptococcus pneumoniae D39 4442128 YP_816183.1 CDS metG NC_008533.1 703998 705995 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 703998..705995 Streptococcus pneumoniae D39 4441489 YP_816184.1 CDS SPD_0690 NC_008533.1 706045 706236 D hypothetical protein 706045..706236 Streptococcus pneumoniae D39 4441946 YP_816185.1 CDS SPD_0691 NC_008533.1 706326 706646 D equivalent gene in S.pneumoniae TIGR4 = SP0789; equivalent gene in S.pneumoniae R6 = spr0697; identified by match to protein family HMM PF03551; hypothetical protein 706326..706646 Streptococcus pneumoniae D39 4442470 YP_816186.1 CDS SPD_0692 NC_008533.1 706650 707525 D equivalent gene in S.pneumoniae TIGR4 = SP0790; equivalent gene in S.pneumoniae R6 = spr0698; hypothetical protein 706650..707525 Streptococcus pneumoniae D39 4442338 YP_816187.1 CDS SPD_0693 NC_008533.1 707540 708466 D equivalent gene in S.pneumoniae TIGR4 = SP0791; equivalent gene in S.pneumoniae R6 = spr0699; identified by match to protein family HMM PF00248; oxidoreductase, aldo/keto reductase family protein 707540..708466 Streptococcus pneumoniae D39 4441551 YP_816188.1 CDS SPD_0694 NC_008533.1 708545 708802 D equivalent gene in S.pneumoniae TIGR4 = SP0792; equivalent gene in S.pneumoniae R6 = spr0700; hypothetical protein 708545..708802 Streptococcus pneumoniae D39 4441656 YP_816189.1 CDS fabG NC_008533.1 708795 709493 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 708795..709493 Streptococcus pneumoniae D39 4442717 YP_816190.1 CDS SPD_0696 NC_008533.1 709504 709983 D equivalent gene in S.pneumoniae TIGR4 = SP0794; equivalent gene in S.pneumoniae R6 = spr0702; identified by match to protein family HMM PF00293; MutT/nudix family protein 709504..709983 Streptococcus pneumoniae D39 4442831 YP_816191.1 CDS SPD_0697 NC_008533.1 709991 710719 D equivalent gene in S.pneumoniae R6 = spr0703; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 709991..710719 Streptococcus pneumoniae D39 4442241 YP_816192.1 CDS SPD_0698 NC_008533.1 710761 711630 D equivalent gene in S.pneumoniae TIGR4 = SP0795; equivalent gene in S.pneumoniae R6 = spr0704; identified by match to protein family HMM PF02896; hypothetical protein 710761..711630 Streptococcus pneumoniae D39 4441062 YP_816193.1 CDS SPD_0699 NC_008533.1 711605 712045 D equivalent gene in S.pneumoniae TIGR4 = SP0796; equivalent gene in S.pneumoniae R6 = spr0705; identified by match to protein family HMM PF06171; hypothetical protein 711605..712045 Streptococcus pneumoniae D39 4443049 YP_816194.1 CDS pepN NC_008533.1 712168 714714 D equivalent gene in S.pneumoniae TIGR4 = SP0797; equivalent gene in S.pneumoniae R6 = spr0706; identified by match to protein family HMM PF01433; aminopeptidase N 712168..714714 Streptococcus pneumoniae D39 4442749 YP_816195.1 CDS ciaR NC_008533.1 714757 715497 D equivalent gene in S.pneumoniae TIGR4 = SP0798; equivalent gene in S.pneumoniae R6 = spr0707; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator CiaR 714757..715497 Streptococcus pneumoniae D39 4441190 YP_816196.1 CDS ciaH NC_008533.1 715487 716821 D equivalent gene in S.pneumoniae TIGR4 = SP0799; equivalent gene in S.pneumoniae R6 = spr0708; identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor histidine kinase CiaH 715487..716821 Streptococcus pneumoniae D39 4441363 YP_816197.1 CDS SPD_0703 NC_008533.1 716855 717142 R equivalent gene in S.pneumoniae TIGR4 = SP0800; equivalent gene in S.pneumoniae R6 = spr0709; hypothetical protein complement(716855..717142) Streptococcus pneumoniae D39 4441816 YP_816198.1 CDS SPD_0704 NC_008533.1 717141 718211 D equivalent gene in S.pneumoniae TIGR4 = SP0801; equivalent gene in S.pneumoniae R6 = spr0710; identified by match to protein family HMM PF01136; hypothetical protein 717141..718211 Streptococcus pneumoniae D39 4441601 YP_816199.1 CDS SPD_0705 NC_008533.1 718411 720861 D unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 718411..720861 Streptococcus pneumoniae D39 4442448 YP_816200.1 CDS SPD_0706 NC_008533.1 720898 722121 D equivalent gene in S.pneumoniae TIGR4 = SP0803; equivalent gene in S.pneumoniae R6 = spr0712; identified by match to protein family HMM PF01098; rod shape-determining protein RodA 720898..722121 Streptococcus pneumoniae D39 4442886 YP_816201.1 CDS SPD_0707 NC_008533.1 722132 722686 D equivalent gene in S.pneumoniae TIGR4 = SP0804; equivalent gene in S.pneumoniae R6 = spr0713; identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 722132..722686 Streptococcus pneumoniae D39 4442031 YP_816202.1 CDS SPD_0708 NC_008533.1 722771 723334 D equivalent gene in S.pneumoniae TIGR4 = SP0805; equivalent gene in S.pneumoniae R6 = spr0714; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; hydrolase 722771..723334 Streptococcus pneumoniae D39 4441111 YP_816203.1 CDS gyrB NC_008533.1 723349 725295 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 723349..725295 Streptococcus pneumoniae D39 4442518 YP_816204.1 CDS ezrA NC_008533.1 725377 727104 D acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 725377..727104 Streptococcus pneumoniae D39 4442078 YP_816205.1 CDS SPD_0711 NC_008533.1 727898 728251 D equivalent gene in S.pneumoniae TIGR4 = SP1487; equivalent gene in S.pneumoniae R6 = spr0717; hypothetical protein 727898..728251 Streptococcus pneumoniae D39 4442747 YP_816206.1 CDS SPD_0712 NC_008533.1 728283 728792 D equivalent gene in S.pneumoniae TIGR4 = SP0811; equivalent gene in S.pneumoniae R6 = spr0718; transposase family protein 728283..728792 Streptococcus pneumoniae D39 4442980 YP_816207.1 CDS SPD_0714 NC_008533.1 729426 729725 R equivalent gene in S.pneumoniae TIGR4 = SP0816; equivalent gene in S.pneumoniae R6 = spr0720; hypothetical protein complement(729426..729725) Streptococcus pneumoniae D39 4441113 YP_816208.1 CDS SPD_0715 NC_008533.1 729890 730312 R equivalent gene in S.pneumoniae TIGR4 = SP0817; equivalent gene in S.pneumoniae R6 = spr0721; identified by match to protein family HMM PF00293; MutT/nudix family protein complement(729890..730312) Streptococcus pneumoniae D39 4441247 YP_816209.1 CDS SPD_0716 NC_008533.1 730405 730752 D equivalent gene in S.pneumoniae TIGR4 = SP0299; equivalent gene in S.pneumoniae R6 = spr0722 In TIGR4 this gene is annotated as a truncation; however in R6 there are numerous near perfect copies as well as copies with a slightly longer version with a different end that is not present in either R6 or TIGR4 This indicates it may still function as a transposase; identified by match to protein family HMM PF01710; IS630-Spn1, transposase Orf1 730405..730752 Streptococcus pneumoniae D39 4441994 YP_816210.1 CDS clpE NC_008533.1 731477 733735 R equivalent gene in S.pneumoniae TIGR4 = SP0820; equivalent gene in S.pneumoniae R6 = spr0725; identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit ClpE complement(731477..733735) Streptococcus pneumoniae D39 4442793 YP_816211.1 CDS SPD_0718 NC_008533.1 733964 734194 R equivalent gene in S.pneumoniae TIGR4 = SP0822; equivalent gene in S.pneumoniae R6 = spr0726; hypothetical protein complement(733964..734194) Streptococcus pneumoniae D39 4442898 YP_816212.1 CDS SPD_0719 NC_008533.1 734384 735067 D equivalent gene in S.pneumoniae TIGR4 = SP0823; equivalent gene in S.pneumoniae R6 = spr0727; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 734384..735067 Streptococcus pneumoniae D39 4441228 YP_816213.1 CDS SPD_0720 NC_008533.1 735067 735801 D equivalent gene in S.pneumoniae TIGR4 = SP0824; equivalent gene in S.pneumoniae R6 = spr0728; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 735067..735801 Streptococcus pneumoniae D39 4441022 YP_816214.1 CDS folD NC_008533.1 735934 736812 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 735934..736812 Streptococcus pneumoniae D39 4441104 YP_816215.1 CDS SPD_0722 NC_008533.1 736954 737826 D equivalent gene in S.pneumoniae R6 = spr0730; identified by match to protein family HMM PF01256; match to protein family HMM TIGR00196; similar to the C-terminus of Escherichia coli YjeF; YjeF-like protein 736954..737826 Streptococcus pneumoniae D39 4442348 YP_816216.1 CDS rpiA NC_008533.1 738108 738791 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 738108..738791 Streptococcus pneumoniae D39 4442565 YP_816217.1 CDS deoB NC_008533.1 738805 740016 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 738805..740016 Streptococcus pneumoniae D39 4442950 YP_816218.1 CDS SPD_0726 NC_008533.1 740576 741385 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 740576..741385 Streptococcus pneumoniae D39 4442637 YP_816219.1 CDS SPD_0727 NC_008533.1 741861 742592 D equivalent gene in S.pneumoniae TIGR4 = SP0833; equivalent gene in S.pneumoniae R6 = spr0735; hypothetical protein 741861..742592 Streptococcus pneumoniae D39 4442685 YP_816220.1 CDS SPD_0728 NC_008533.1 742638 742841 D equivalent gene in S.pneumoniae TIGR4 = SP0833; equivalent gene in S.pneumoniae R6 = spr0736; hypothetical protein 742638..742841 Streptococcus pneumoniae D39 4441832 YP_816221.1 CDS SPD_0729 NC_008533.1 742866 743378 D equivalent gene in S.pneumoniae TIGR4 = SP0834; equivalent gene in S.pneumoniae R6 = spr0737; hemolysin-like protein 742866..743378 Streptococcus pneumoniae D39 4441996 YP_816222.1 CDS deoD NC_008533.1 744036 744746 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 744036..744746 Streptococcus pneumoniae D39 4442701 YP_816223.1 CDS SPD_0731 NC_008533.1 744769 745293 R equivalent gene in S.pneumoniae TIGR4 = SP0837; equivalent gene in S.pneumoniae R6 = spr0739; topology modulation protein complement(744769..745293) Streptococcus pneumoniae D39 4442294 YP_816224.1 CDS rpsT NC_008533.1 745346 745582 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(745346..745582) Streptococcus pneumoniae D39 4442546 YP_816225.1 CDS coaA NC_008533.1 745650 746570 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(745650..746570) Streptococcus pneumoniae D39 4441674 YP_816226.1 CDS SPD_0734 NC_008533.1 746768 747208 D equivalent gene in S.pneumoniae TIGR4 = SP0840; equivalent gene in S.pneumoniae R6 = spr0742; hypothetical protein 746768..747208 Streptococcus pneumoniae D39 4443041 YP_816227.1 CDS SPD_0735 NC_008533.1 747415 748005 D equivalent gene in S.pneumoniae TIGR4 = SP0841; equivalent gene in S.pneumoniae R6 = spr0743; identified by match to protein family HMM PF05175; methyltransferase small subunit 747415..748005 Streptococcus pneumoniae D39 4442693 YP_816228.1 CDS pdp NC_008533.1 748002 749279 D Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 748002..749279 Streptococcus pneumoniae D39 4442945 YP_816229.1 CDS deoC NC_008533.1 749297 749959 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 749297..749959 Streptococcus pneumoniae D39 4441871 YP_816230.1 CDS cdd-1 NC_008533.1 749946 750335 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 749946..750335 Streptococcus pneumoniae D39 4441642 YP_816231.1 CDS SPD_0739 NC_008533.1 750425 751477 D equivalent gene in S.pneumoniae TIGR4 = SP0845; equivalent gene in S.pneumoniae R6 = spr0747; identified by match to protein family HMM PF02608; membrane lipoprotein TmpC 750425..751477 Streptococcus pneumoniae D39 4442029 YP_816232.1 CDS SPD_0740 NC_008533.1 751621 753156 D equivalent gene in S.pneumoniae TIGR4 = SP0846; equivalent gene in S.pneumoniae R6 = spr0748; identified by match to protein family HMM PF00005; sugar ABC transporter ATP-binding protein 751621..753156 Streptococcus pneumoniae D39 4441546 YP_816233.1 CDS SPD_0741 NC_008533.1 753149 754207 D equivalent gene in S.pneumoniae TIGR4 = SP0847; equivalent gene in S.pneumoniae R6 = spr0749; identified by match to protein family HMM PF02653; sugar ABC transporter permease 753149..754207 Streptococcus pneumoniae D39 4441236 YP_816234.1 CDS SPD_0742 NC_008533.1 754210 755166 D equivalent gene in S.pneumoniae TIGR4 = SP0848; equivalent gene in S.pneumoniae R6 = spr0750; identified by match to protein family HMM PF02653; sugar ABC transporter permease 754210..755166 Streptococcus pneumoniae D39 4442455 YP_816235.1 CDS SPD_0745 NC_008533.1 756641 757282 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY complement(756641..757282) Streptococcus pneumoniae D39 4441317 YP_816236.1 CDS parE NC_008533.1 757418 759361 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 757418..759361 Streptococcus pneumoniae D39 4441038 YP_816237.1 CDS SPD_0747 NC_008533.1 759482 759607 D equivalent gene in S.pneumoniae TIGR4 = SP0854; hypothetical protein 759482..759607 Streptococcus pneumoniae D39 4442585 YP_816238.1 CDS parC NC_008533.1 759772 762252 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 759772..762252 Streptococcus pneumoniae D39 4442711 YP_816239.1 CDS ilvE NC_008533.1 762382 763404 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 762382..763404 Streptococcus pneumoniae D39 4441506 YP_816240.1 CDS SPD_0750 NC_008533.1 763460 764164 D equivalent gene in S.pneumoniae R6 = spr0759; hypothetical protein 763460..764164 Streptococcus pneumoniae D39 4442247 YP_816241.1 CDS SPD_0751 NC_008533.1 764229 764918 D equivalent gene in S.pneumoniae TIGR4 = SP0858; equivalent gene in S.pneumoniae R6 = spr0760; identified by match to protein family HMM PF06149; hypothetical protein 764229..764918 Streptococcus pneumoniae D39 4441776 YP_816242.1 CDS SPD_0752 NC_008533.1 764915 765838 D equivalent gene in S.pneumoniae TIGR4 = SP0859; equivalent gene in S.pneumoniae R6 = spr0761; identified by match to protein family HMM PF06166; hypothetical protein 764915..765838 Streptococcus pneumoniae D39 4441910 YP_816243.1 CDS pcp NC_008533.1 765853 766497 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 765853..766497 Streptococcus pneumoniae D39 4441189 YP_816244.1 CDS SPD_0754 NC_008533.1 766665 766895 D equivalent gene in S.pneumoniae TIGR4 = SP0861; equivalent gene in S.pneumoniae R6 = spr0763; hypothetical protein 766665..766895 Streptococcus pneumoniae D39 4442796 YP_816245.1 CDS rpsA NC_008533.1 767268 768470 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 767268..768470 Streptococcus pneumoniae D39 4442889 YP_816246.1 CDS SPD_0759 NC_008533.1 770126 770623 D equivalent gene in S.pneumoniae TIGR4 = SP0864; equivalent gene in S.pneumoniae R6 = spr0768; hypothetical protein 770126..770623 Streptococcus pneumoniae D39 4441319 YP_816247.1 CDS dnaX NC_008533.1 770623 772278 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 770623..772278 Streptococcus pneumoniae D39 4442929 YP_816248.1 CDS SPD_0761 NC_008533.1 772306 772500 D equivalent gene in S.pneumoniae TIGR4 = SP0866; equivalent gene in S.pneumoniae R6 = spr0770; hypothetical protein 772306..772500 Streptococcus pneumoniae D39 4441617 YP_816249.1 CDS sufC NC_008533.1 772650 773420 D equivalent gene in S.pneumoniae TIGR4 = SP0867; equivalent gene in S.pneumoniae R6 = spr0771; identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978; FeS assembly ATPase SufC 772650..773420 Streptococcus pneumoniae D39 4441806 YP_816250.1 CDS sufD NC_008533.1 773448 774710 D equivalent gene in S.pneumoniae TIGR4 = SP0868; equivalent gene in S.pneumoniae R6 = spr0772; identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981; hypothetical protein 773448..774710 Streptococcus pneumoniae D39 4441634 YP_816251.1 CDS sufS NC_008533.1 774721 775947 D equivalent gene in S.pneumoniae TIGR4 = SP0869; equivalent gene in S.pneumoniae R6 = spr0773; identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979; cysteine desulfurase SufS subfamily protein 774721..775947 Streptococcus pneumoniae D39 4442030 YP_816252.1 CDS SPD_0765 NC_008533.1 775934 776374 D equivalent gene in S.pneumoniae TIGR4 = SP0870; equivalent gene in S.pneumoniae R6 = spr0774; identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994; SUF system FeS assembly protein, NifU family protein 775934..776374 Streptococcus pneumoniae D39 4441353 YP_816253.1 CDS sufB NC_008533.1 776428 777840 D equivalent gene in S.pneumoniae TIGR4 = SP0871; equivalent gene in S.pneumoniae R6 = spr0775; identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980; FeS assembly protein SufB 776428..777840 Streptococcus pneumoniae D39 4442540 YP_816254.1 CDS dacC NC_008533.1 778039 779280 R equivalent gene in S.pneumoniae TIGR4 = SP0872; equivalent gene in S.pneumoniae R6 = spr0776; identified by match to protein family HMM PF00768; match to protein family HMM PF07943; D-alanyl-D-alanine carboxypeptidase complement(778039..779280) Streptococcus pneumoniae D39 4442627 YP_816255.1 CDS SPD_0768 NC_008533.1 779383 780492 D equivalent gene in S.pneumoniae TIGR4 = SP0873; equivalent gene in S.pneumoniae R6 = spr0777; identified by match to protein family HMM PF01594; hypothetical protein 779383..780492 Streptococcus pneumoniae D39 4442213 YP_816256.1 CDS lacR1 NC_008533.1 781917 782657 D equivalent gene in S.pneumoniae TIGR4 = SP0875; equivalent gene in S.pneumoniae R6 = spr0778; identified by match to protein family HMM PF00455; match to protein family HMM PF08220; lactose phosphotransferase system repressor 781917..782657 Streptococcus pneumoniae D39 4442875 YP_816257.1 CDS SPD_0772 NC_008533.1 782654 783565 D equivalent gene in S.pneumoniae TIGR4 = SP0876; equivalent gene in S.pneumoniae R6 = spr0779; identified by match to protein family HMM PF00294; 1-phosphofructokinase 782654..783565 Streptococcus pneumoniae D39 4442115 YP_816258.1 CDS SPD_0773 NC_008533.1 783562 785514 D equivalent gene in S.pneumoniae TIGR4 = SP0877; equivalent gene in S.pneumoniae R6 = spr0780; identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427; PTS system fructose specific transporter subunit IIABC 783562..785514 Streptococcus pneumoniae D39 4441481 YP_816259.1 CDS SPD_0774 NC_008533.1 785600 787903 D equivalent gene in S.pneumoniae TIGR4 = SP0878; equivalent gene in S.pneumoniae R6 = spr0781; identified by match to protein family HMM PF01580; SpoE family protein 785600..787903 Streptococcus pneumoniae D39 4441961 YP_816260.1 CDS SPD_0775 NC_008533.1 787948 788481 R equivalent gene in S.pneumoniae TIGR4 = SP0879; equivalent gene in S.pneumoniae R6 = spr0782; hypothetical protein complement(787948..788481) Streptococcus pneumoniae D39 4442630 YP_816261.1 CDS SPD_0776 NC_008533.1 788514 789656 D equivalent gene in S.pneumoniae TIGR4 = SP0880; equivalent gene in S.pneumoniae R6 = spr0783; identified by match to protein family HMM PF00266; class V aminotransferase 788514..789656 Streptococcus pneumoniae D39 4442476 YP_816262.1 CDS thiI NC_008533.1 789665 790879 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 789665..790879 Streptococcus pneumoniae D39 4443063 YP_816263.1 CDS SPD_0778 NC_008533.1 791014 791838 D equivalent gene in S.pneumoniae TIGR4 = SP0882; equivalent gene in S.pneumoniae R6 = spr0785; identified by match to protein family HMM PF00756; hypothetical protein 791014..791838 Streptococcus pneumoniae D39 4442728 YP_816264.1 CDS SPD_0779 NC_008533.1 791860 792195 D equivalent gene in S.pneumoniae TIGR4 = SP0883; equivalent gene in S.pneumoniae R6 = spr0786; hypothetical protein 791860..792195 Streptococcus pneumoniae D39 4441972 YP_816265.1 CDS SPD_0780 NC_008533.1 792195 792599 D equivalent gene in S.pneumoniae TIGR4 = SP0884; equivalent gene in S.pneumoniae R6 = spr0788; hypothetical protein 792195..792599 Streptococcus pneumoniae D39 4441526 YP_816266.1 CDS SPD_0781 NC_008533.1 792612 793778 D equivalent gene in S.pneumoniae TIGR4 = SP0885; equivalent gene in S.pneumoniae R6 = spr0789; hypothetical protein 792612..793778 Streptococcus pneumoniae D39 4441948 YP_816267.1 CDS SPD_0782 NC_008533.1 794286 795779 D equivalent gene in S.pneumoniae TIGR4 = SP0886; equivalent gene in S.pneumoniae R6 = spr0790; identified by match to protein family HMM PF02384; type I restriction-modification system, M subunit 794286..795779 Streptococcus pneumoniae D39 4441110 YP_816268.1 CDS SPD_0783 NC_008533.1 795792 796403 D equivalent gene in S.pneumoniae TIGR4 = SP0887; equivalent gene in S.pneumoniae R6 = spr0791; identified by match to protein family HMM PF01420; type I restriction-modification system subunit S 795792..796403 Streptococcus pneumoniae D39 4441084 YP_816269.1 CDS SPD_0784 NC_008533.1 796482 799832 D equivalent gene in S.pneumoniae TIGR4 = SP0892; equivalent gene in S.pneumoniae R6 = spr0792; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system, R subunit 796482..799832 Streptococcus pneumoniae D39 4441627 YP_816270.1 CDS SPD_0785 NC_008533.1 800103 800303 D hypothetical protein 800103..800303 Streptococcus pneumoniae D39 4441250 YP_816271.1 CDS SPD_0786 NC_008533.1 800418 800888 R equivalent gene in S.pneumoniae TIGR4 = SP0893; equivalent gene in S.pneumoniae R6 = spr0793; identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional regulator of arginine metabolism expression complement(800418..800888) Streptococcus pneumoniae D39 4442094 YP_816272.1 CDS pepX NC_008533.1 800905 803178 R catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase complement(800905..803178) Streptococcus pneumoniae D39 4441586 YP_816273.1 CDS dnaE NC_008533.1 803524 806625 D Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 803524..806625 Streptococcus pneumoniae D39 4442164 YP_816274.1 CDS pfkA NC_008533.1 806708 807715 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 806708..807715 Streptococcus pneumoniae D39 4441501 YP_816275.1 CDS pyk NC_008533.1 807774 809279 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 807774..809279 Streptococcus pneumoniae D39 4442113 YP_816276.1 CDS SPD_0791 NC_008533.1 810396 810650 R equivalent gene in S.pneumoniae R6 = spr0798; hypothetical protein complement(810396..810650) Streptococcus pneumoniae D39 4443003 YP_816277.1 CDS SPD_0792 NC_008533.1 811086 811958 D equivalent gene in S.pneumoniae TIGR4 = SP0899; equivalent gene in S.pneumoniae R6 = spr0799; hypothetical protein 811086..811958 Streptococcus pneumoniae D39 4441630 YP_816278.1 CDS SPD_0793 NC_008533.1 811971 812135 D equivalent gene in S.pneumoniae R6 = spr0800; hypothetical protein 811971..812135 Streptococcus pneumoniae D39 4442544 YP_816279.1 CDS SPD_0795 NC_008533.1 812591 812902 D equivalent gene in S.pneumoniae TIGR4 = SP0901; equivalent gene in S.pneumoniae R6 = spr0802; hypothetical protein 812591..812902 Streptococcus pneumoniae D39 4442677 YP_816280.1 CDS SPD_0796 NC_008533.1 812906 813622 D equivalent gene in S.pneumoniae R6 = spr0803; hypothetical protein 812906..813622 Streptococcus pneumoniae D39 4441845 YP_816281.1 CDS SPD_0797 NC_008533.1 813752 814567 R equivalent gene in S.pneumoniae TIGR4 = SP0904; equivalent gene in S.pneumoniae R6 = spr0804; hypothetical protein complement(813752..814567) Streptococcus pneumoniae D39 4442299 YP_816282.1 CDS SPD_0798 NC_008533.1 814564 815469 R equivalent gene in S.pneumoniae TIGR4 = SP0905; equivalent gene in S.pneumoniae R6 = spr0805; identified by match to protein family HMM PF03773; hypothetical protein complement(814564..815469) Streptococcus pneumoniae D39 4442185 YP_816283.1 CDS SPD_0799 NC_008533.1 815470 815601 R equivalent gene in S.pneumoniae TIGR4 = SP0906; hypothetical protein complement(815470..815601) Streptococcus pneumoniae D39 4441312 YP_816284.1 CDS SPD_0800 NC_008533.1 815811 816170 D equivalent gene in S.pneumoniae TIGR4 = SP0907; equivalent gene in S.pneumoniae R6 = spr0806 The TIGR4 equivalent gene has 130 more amino acids than the D39 or R6 genes.; capsular polysaccharide biosynthesis protein 815811..816170 Streptococcus pneumoniae D39 4442826 YP_816285.1 CDS SPD_0801 NC_008533.1 816133 817179 D equivalent gene in S.pneumoniae TIGR4 = SP0907; equivalent gene in S.pneumoniae R6 = spr0807; hypothetical protein 816133..817179 Streptococcus pneumoniae D39 4441850 YP_816286.1 CDS SPD_0802 NC_008533.1 817281 819410 D equivalent gene in S.pneumoniae TIGR4 = SP0908; equivalent gene in S.pneumoniae R6 = spr0808; identified by match to protein family HMM PF00575; S1 RNA-binding domain-containing protein 817281..819410 Streptococcus pneumoniae D39 4442538 YP_816287.1 CDS SPD_0803 NC_008533.1 819905 820177 D equivalent gene in S.pneumoniae TIGR4 = SP0910; equivalent gene in S.pneumoniae R6 = spr0810; identified by match to protein family HMM PF04024; hypothetical protein 819905..820177 Streptococcus pneumoniae D39 4442054 YP_816288.1 CDS SPD_0804 NC_008533.1 821150 821908 D equivalent gene in S.pneumoniae TIGR4 = SP0912; equivalent gene in S.pneumoniae R6 = spr0812; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 821150..821908 Streptococcus pneumoniae D39 4441033 YP_816289.1 CDS SPD_0805 NC_008533.1 821910 823898 D equivalent gene in S.pneumoniae TIGR4 = SP0913; equivalent gene in S.pneumoniae R6 = spr0813; identified by match to protein family HMM PF02687; transporter permease 821910..823898 Streptococcus pneumoniae D39 4441525 YP_816290.1 CDS SPD_0806 NC_008533.1 823941 824531 R Gene encodes 3 transmembrane regions. equivalent gene in S.pneumoniae TIGR4 = SP0914; equivalent gene in S.pneumoniae R6 spr0814; identified by match to protein family HMM PF01988; hypothetical protein complement(823941..824531) Streptococcus pneumoniae D39 4441616 YP_816291.1 CDS SPD_0807 NC_008533.1 824611 825486 R equivalent gene in S.pneumoniae TIGR4 = SP0915; equivalent gene in S.pneumoniae R6 = spr0815; identified by match to protein family HMM PF00665; IS1239, transposase complement(824611..825486) Streptococcus pneumoniae D39 4441660 YP_816292.1 CDS SPD_0808 NC_008533.1 825719 825832 R hypothetical protein complement(825719..825832) Streptococcus pneumoniae D39 4441290 YP_816293.1 CDS cad NC_008533.1 826193 827668 D equivalent gene in S.pneumoniae TIGR4 = SP0916; equivalent gene in S.pneumoniae R6 = spr0816; identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF01276; match to protein family HMM PF03711; lysine decarboxylase 826193..827668 Streptococcus pneumoniae D39 4442920 YP_816294.1 CDS speE NC_008533.1 828605 829465 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 828605..829465 Streptococcus pneumoniae D39 4442263 YP_816295.1 CDS lys1 NC_008533.1 829462 830721 D equivalent gene in S.pneumoniae TIGR4 = SP0919; equivalent gene in S.pneumoniae R6 = spr0820; identified by match to protein family HMM PF03435; hypothetical protein 829462..830721 Streptococcus pneumoniae D39 4442277 YP_816296.1 CDS nspC NC_008533.1 830721 831848 D equivalent gene in S.pneumoniae TIGR4 = SP0920; equivalent gene in S.pneumoniae R6 = spr0821; identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047; carboxynorspermidine decarboxylase 830721..831848 Streptococcus pneumoniae D39 4442465 YP_816297.1 CDS SPD_0814 NC_008533.1 831845 832930 D agmatine iminohydrolase; catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 831845..832930 Streptococcus pneumoniae D39 4442754 YP_816298.1 CDS SPD_0815 NC_008533.1 832940 833815 D equivalent gene in S.pneumoniae TIGR4 = SP0922; equivalent gene in S.pneumoniae R6 = spr0823; identified by match to protein family HMM PF00795; carbon-nitrogen hydrolase 832940..833815 Streptococcus pneumoniae D39 4442079 YP_816299.1 CDS SPD_0816 NC_008533.1 833996 834805 R equivalent gene in S.pneumoniae TIGR4 = SP0923; equivalent gene in S.pneumoniae R6 = spr0824; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(833996..834805) Streptococcus pneumoniae D39 4441570 YP_816300.1 CDS SPD_0817 NC_008533.1 835352 836023 D equivalent gene in S.pneumoniae TIGR4 = SP0925; equivalent gene in S.pneumoniae R6 = spr0826; identified by match to protein family HMM PF02517; hypothetical protein 835352..836023 Streptococcus pneumoniae D39 4442341 YP_816301.1 CDS SPD_0818 NC_008533.1 836265 837173 D equivalent gene in S.pneumoniae TIGR4 = SP0927; equivalent gene in S.pneumoniae R6 = spr0828; identified by match to protein family HMM PF00126; match to protein family HMM PF03466; transcriptional regulator, LysR family protein 836265..837173 Streptococcus pneumoniae D39 4441252 YP_816302.1 CDS lspA NC_008533.1 837170 837631 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 837170..837631 Streptococcus pneumoniae D39 4441040 YP_816303.1 CDS rluD NC_008533.1 837621 838508 D equivalent gene in S.pneumoniae TIGR4 = SP0929; equivalent gene in S.pneumoniae R6 = spr0830; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D 837621..838508 Streptococcus pneumoniae D39 4442468 YP_816304.1 CDS cbpE NC_008533.1 838511 840394 D equivalent gene in S.pneumoniae TIGR4 = SP0930; equivalent gene in S.pneumoniae R6 = spr0831; identified by match to protein family HMM PF00753; match to protein family HMM PF01473; choline binding protein E 838511..840394 Streptococcus pneumoniae D39 4441485 YP_816305.1 CDS proB NC_008533.1 840495 841604 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 840495..841604 Streptococcus pneumoniae D39 4442275 YP_816306.1 CDS proA NC_008533.1 841614 842876 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 841614..842876 Streptococcus pneumoniae D39 4442516 YP_816307.1 CDS proC NC_008533.1 842880 843677 D equivalent gene in S.pneumoniae TIGR4 = SP0933; equivalent gene in S.pneumoniae R6 = spr0834; identified by match to protein family HMM PF01210; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR00112; pyrroline-5-carboxylate reductase 842880..843677 Streptococcus pneumoniae D39 4442577 YP_816308.1 CDS tmk NC_008533.1 843793 844431 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 843793..844431 Streptococcus pneumoniae D39 4441266 YP_816309.1 CDS holB NC_008533.1 844428 845318 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 844428..845318 Streptococcus pneumoniae D39 4442252 YP_816310.1 CDS SPD_0827 NC_008533.1 845358 845675 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 845358..845675 Streptococcus pneumoniae D39 4442815 YP_816311.1 CDS SPD_0828 NC_008533.1 845678 846547 D equivalent gene in S.pneumoniae TIGR4 = SP0938; equivalent gene in S.pneumoniae R6 = spr0838; identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; hypothetical protein 845678..846547 Streptococcus pneumoniae D39 4443000 YP_816312.1 CDS SPD_0829 NC_008533.1 846774 847292 D equivalent gene in S.pneumoniae TIGR4 = SP0939; equivalent gene in S.pneumoniae R6 = spr0839; identified by match to protein family HMM PF08020; hypothetical protein 846774..847292 Streptococcus pneumoniae D39 4441815 YP_816313.1 CDS SPD_0831 NC_008533.1 847401 848048 D equivalent gene in S.pneumoniae R6 = spr0840; identified by match to protein family HMM PF06970; hypothetical protein 847401..848048 Streptococcus pneumoniae D39 4442981 YP_816314.1 CDS SPD_0830 NC_008533.1 848037 848426 R equivalent gene in S.pneumoniae TIGR4 = SP0538; equivalent gene in S.pneumoniae R6 = spr0841; identified by match to protein family HMM PF01609; IS1381, transposase OrfB complement(848037..848426) Streptococcus pneumoniae D39 4441581 YP_816315.1 CDS SPD_0832 NC_008533.1 848452 848841 R equivalent gene in S.pneumoniae TIGR4 = SP0942; equivalent gene in S.pneumoniae R6 = spr0842; IS1381, transposase OrfA complement(848452..848841) Streptococcus pneumoniae D39 4442614 YP_816316.1 CDS gid NC_008533.1 849335 850669 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 849335..850669 Streptococcus pneumoniae D39 4441431 YP_816317.1 CDS pyrH NC_008533.1 850753 851490 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 850753..851490 Streptococcus pneumoniae D39 4441192 YP_816318.1 CDS frr NC_008533.1 851499 852056 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 851499..852056 Streptococcus pneumoniae D39 4442138 YP_816319.1 CDS SPD_0836 NC_008533.1 852077 852970 D equivalent gene in S.pneumoniae TIGR4 = SP0946; equivalent gene in S.pneumoniae R6 = spr0847; hypothetical protein 852077..852970 Streptococcus pneumoniae D39 4441205 YP_816320.1 CDS SPD_0837 NC_008533.1 852979 853194 D equivalent gene in S.pneumoniae TIGR4 = SP0947; equivalent gene in S.pneumoniae R6 = spr0848; identified by match to protein family HMM PF06855; hypothetical protein 852979..853194 Streptococcus pneumoniae D39 4441917 YP_816321.1 CDS SPD_0838 NC_008533.1 853280 854248 D equivalent gene in S.pneumoniae TIGR4 = SP0948; equivalent gene in S.pneumoniae R6 = spr0849; identified by match to protein family HMM PF02562; PhoH family protein 853280..854248 Streptococcus pneumoniae D39 4441688 YP_816322.1 CDS SPD_0839 NC_008533.1 854441 854941 D equivalent gene in S.pneumoniae TIGR4 = SP0950; equivalent gene in S.pneumoniae R6 = spr0850; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 854441..854941 Streptococcus pneumoniae D39 4441764 YP_816323.1 CDS SPD_0840 NC_008533.1 854944 855171 D equivalent gene in S.pneumoniae TIGR4 = SP0951; equivalent gene in S.pneumoniae R6 = spr0851; hypothetical protein 854944..855171 Streptococcus pneumoniae D39 4441895 YP_816324.1 CDS SPD_0842 NC_008533.1 856859 857428 D equivalent gene in S.pneumoniae TIGR4 = SP0953; equivalent gene in S.pneumoniae R6 = spr0855; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 856859..857428 Streptococcus pneumoniae D39 4441498 YP_816325.1 CDS celA NC_008533.1 857496 858146 D equivalent gene in S.pneumoniae TIGR4 = SP0954; equivalent gene in S.pneumoniae R6 = spr0856; identified by match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; competence protein CelA 857496..858146 Streptococcus pneumoniae D39 4442825 YP_816326.1 CDS celB NC_008533.1 858130 860370 D equivalent gene in S.pneumoniae TIGR4 = SP0955; equivalent gene in S.pneumoniae R6 = spr0857; identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; competence protein CelB 858130..860370 Streptococcus pneumoniae D39 4441310 YP_816327.1 CDS SPD_0845 NC_008533.1 860769 861245 D equivalent gene in S.pneumoniae TIGR4 = SP0957; equivalent gene in S.pneumoniae R6 = spr0859; ABC transporter ATP-binding protein 860769..861245 Streptococcus pneumoniae D39 4442531 YP_816328.1 CDS SPD_0846 NC_008533.1 861360 862541 D equivalent gene in S.pneumoniae TIGR4 = SP0958; equivalent gene in S.pneumoniae R6 = spr0860; hypothetical protein 861360..862541 Streptococcus pneumoniae D39 4441844 YP_816329.1 CDS infC NC_008533.1 862821 863378 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 862821..863378 Streptococcus pneumoniae D39 4441324 YP_816330.1 CDS rpmI NC_008533.1 863411 863611 D equivalent gene in S.pneumoniae TIGR4 = SP0960; equivalent gene in S.pneumoniae R6 = spr0862; identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 863411..863611 Streptococcus pneumoniae D39 4442928 YP_816331.1 CDS rplT NC_008533.1 863663 864022 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 863663..864022 Streptococcus pneumoniae D39 4441049 YP_816332.1 CDS gloA NC_008533.1 864080 864460 D equivalent gene in S.pneumoniae TIGR4 = SP0962; equivalent gene in S.pneumoniae R6 = spr0864; identified by match to protein family HMM PF00903; lactoylglutathione lyase 864080..864460 Streptococcus pneumoniae D39 4442249 YP_816333.1 CDS pyrK NC_008533.1 864710 865510 D responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 864710..865510 Streptococcus pneumoniae D39 4442427 YP_816334.1 CDS pyrDb NC_008533.1 865521 866459 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 865521..866459 Streptococcus pneumoniae D39 4441945 YP_816335.1 CDS lytB NC_008533.1 866558 868666 D equivalent gene in S.pneumoniae R6 = spr0867; identified by match to protein family HMM PF01473; match to protein family HMM PF01832; endo-beta-N-acetylglucosaminidase 866558..868666 Streptococcus pneumoniae D39 4441884 YP_816336.1 CDS pavA NC_008533.1 868727 870382 R equivalent gene in S.pneumoniae TIGR4 = SP0966; equivalent gene in S.pneumoniae R6 = spr0868; identified by match to protein family HMM PF05670; match to protein family HMM PF05833; adherence and virulence protein A complement(868727..870382) Streptococcus pneumoniae D39 4442613 YP_816337.1 CDS SPD_0855 NC_008533.1 870487 870984 D equivalent gene in S.pneumoniae TIGR4 = SP0967; equivalent gene in S.pneumoniae R6 = spr0869; identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; metalloprotease 870487..870984 Streptococcus pneumoniae D39 4442829 YP_816338.1 CDS dgkA NC_008533.1 870965 871360 D equivalent gene in S.pneumoniae TIGR4 = SP0968; equivalent gene in S.pneumoniae R6 = spr0870; identified by match to protein family HMM PF01219; diacylglycerol kinase 870965..871360 Streptococcus pneumoniae D39 4442753 YP_816339.1 CDS era NC_008533.1 871377 872276 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 871377..872276 Streptococcus pneumoniae D39 4442273 YP_816340.1 CDS mutM NC_008533.1 872325 873149 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 872325..873149 Streptococcus pneumoniae D39 4441068 YP_816341.1 CDS coaE NC_008533.1 873149 873754 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 873149..873754 Streptococcus pneumoniae D39 4441980 YP_816342.1 CDS pmrA NC_008533.1 873741 874940 D equivalent gene in S.pneumoniae TIGR4 = SP0972; equivalent gene in S.pneumoniae R6 = spr0875; identified by match to protein family HMM PF07690; multi-drug resistance efflux pump 873741..874940 Streptococcus pneumoniae D39 4441140 YP_816343.1 CDS secG NC_008533.1 875129 875362 D equivalent gene in S.pneumoniae TIGR4 = SP0974; equivalent gene in S.pneumoniae R6 = spr0877; identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 875129..875362 Streptococcus pneumoniae D39 4442165 YP_816344.1 CDS rnr NC_008533.1 875464 877818 D equivalent gene in S.pneumoniae TIGR4 = SP0975; equivalent gene in S.pneumoniae R6 = spr0878; identified by match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM PF08206; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063; ribonuclease R 875464..877818 Streptococcus pneumoniae D39 4441338 YP_816345.1 CDS smpB NC_008533.1 877781 878248 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 877781..878248 Streptococcus pneumoniae D39 4442569 YP_816346.1 CDS tehB NC_008533.1 878264 879124 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 878264..879124 Streptococcus pneumoniae D39 4442746 YP_816347.1 CDS coiA NC_008533.1 879197 880150 D equivalent gene in S.pneumoniae TIGR4 = SP0978; equivalent gene in S.pneumoniae R6 = spr0881; identified by match to protein family HMM PF06054; competence protein CoiA 879197..880150 Streptococcus pneumoniae D39 4441768 YP_816348.1 CDS pepF NC_008533.1 880169 881971 D equivalent gene in S.pneumoniae TIGR4 = SP0979; equivalent gene in S.pneumoniae R6 = spr0882; identified by match to protein family HMM PF01432; match to protein family HMM TIGR00181; oligoendopeptidase F 880169..881971 Streptococcus pneumoniae D39 4442482 YP_816349.1 CDS SPD_0867 NC_008533.1 881973 882686 D equivalent gene in S.pneumoniae TIGR4 = SP0980; equivalent gene in S.pneumoniae R6 = spr0883; identified by match to protein family HMM PF01596; O-methyltransferase 881973..882686 Streptococcus pneumoniae D39 4441580 YP_816350.1 CDS prsA NC_008533.1 882753 883694 D cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase protein PrsA 882753..883694 Streptococcus pneumoniae D39 4441933 YP_816351.1 CDS SPD_0869 NC_008533.1 883912 884154 R equivalent gene in S.pneumoniae TIGR4 = SP1485; equivalent gene in S.pneumoniae R6 = spr0885; hypothetical protein complement(883912..884154) Streptococcus pneumoniae D39 4441070 YP_816352.1 CDS SPD_0870 NC_008533.1 884914 885534 R equivalent gene in S.pneumoniae TIGR4 = SP0984; equivalent gene in S.pneumoniae R6 = spr0887; identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein complement(884914..885534) Streptococcus pneumoniae D39 4442303 YP_816353.1 CDS SPD_0871 NC_008533.1 885534 886016 R equivalent gene in S.pneumoniae TIGR4 = SP0985; equivalent gene in S.pneumoniae R6 = spr0888; identified by match to protein family HMM PF04073; regulatory protein complement(885534..886016) Streptococcus pneumoniae D39 4441638 YP_816354.1 CDS SPD_0872 NC_008533.1 886016 886858 R equivalent gene in S.pneumoniae TIGR4 = SP0986; equivalent gene in S.pneumoniae R6 = spr0889; identified by match to protein family HMM PF04018; hypothetical protein complement(886016..886858) Streptococcus pneumoniae D39 4442007 YP_816355.1 CDS SPD_0873 NC_008533.1 886953 887753 R equivalent gene in S.pneumoniae TIGR4 = SP0987; equivalent gene in S.pneumoniae R6 = spr0890; identified by match to protein family HMM PF01183; hypothetical protein complement(886953..887753) Streptococcus pneumoniae D39 4441962 YP_816356.1 CDS glmU NC_008533.1 887897 889276 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 887897..889276 Streptococcus pneumoniae D39 4442846 YP_816357.1 CDS SPD_0875 NC_008533.1 889286 889831 D equivalent gene in S.pneumoniae TIGR4 = SP0989; equivalent gene in S.pneumoniae R6 = spr0892; identified by match to protein family HMM PF00293; NUDIX family hydrolase 889286..889831 Streptococcus pneumoniae D39 4441168 YP_816358.1 CDS SPD_0876 NC_008533.1 889843 890157 D equivalent gene in S.pneumoniae TIGR4 = SP0990; equivalent gene in S.pneumoniae R6 = spr0893; hypothetical protein 889843..890157 Streptococcus pneumoniae D39 4441664 YP_816359.1 CDS mtnN NC_008533.1 890174 890866 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 890174..890866 Streptococcus pneumoniae D39 4442289 YP_816360.1 CDS SPD_0878 NC_008533.1 890943 891434 D equivalent gene in S.pneumoniae TIGR4 = SP0992; equivalent gene in S.pneumoniae R6 = spr0895; identified by match to protein family HMM PF04394; hypothetical protein 890943..891434 Streptococcus pneumoniae D39 4442674 YP_816361.1 CDS SPD_0879 NC_008533.1 891532 892122 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 891532..892122 Streptococcus pneumoniae D39 4441340 YP_816362.1 CDS SPD_0880 NC_008533.1 892131 893894 D equivalent gene in S.pneumoniae TIGR4 = SP0994; equivalent gene in S.pneumoniae R6 = spr0897; identified by match to protein family HMM PF03009; hypothetical protein 892131..893894 Streptococcus pneumoniae D39 4442621 YP_816363.1 CDS SPD_0882 NC_008533.1 894614 894754 D equivalent gene in S.pneumoniae R6 = spr0899; IS630-Spn1, transposase Orf2, truncation 894614..894754 Streptococcus pneumoniae D39 4442492 YP_816364.1 CDS SPD_0883 NC_008533.1 894915 895115 D equivalent gene in S.pneumoniae TIGR4 = SP0997; equivalent gene in S.pneumoniae R6 = spr0900; hypothetical protein 894915..895115 Streptococcus pneumoniae D39 4443019 YP_816365.1 CDS SPD_0884 NC_008533.1 895157 895561 D equivalent gene in S.pneumoniae TIGR4 = SP0998; equivalent gene in S.pneumoniae R6 = spr0902; hypothetical protein 895157..895561 Streptococcus pneumoniae D39 4441965 YP_816366.1 CDS ccdA-2 NC_008533.1 895792 896499 D equivalent gene in S.pneumoniae TIGR4 = SP0999; equivalent gene in S.pneumoniae R6 = spr0903; identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 895792..896499 Streptococcus pneumoniae D39 4442599 YP_816367.1 CDS SPD_0886 NC_008533.1 896510 897067 D equivalent gene in S.pneumoniae TIGR4 = SP1000; equivalent gene in S.pneumoniae R6 = spr0904; thioredoxin family protein 896510..897067 Streptococcus pneumoniae D39 4441947 YP_816368.1 CDS SPD_0887 NC_008533.1 897441 898832 D equivalent gene in S.pneumoniae TIGR4 = SP1001; equivalent gene in S.pneumoniae R6 = spr0905; identified by match to protein family HMM PF00324; amino acid permease family protein 897441..898832 Streptococcus pneumoniae D39 4442602 YP_816369.1 CDS lmb NC_008533.1 898975 899892 D equivalent gene in S.pneumoniae TIGR4 = SP1002; equivalent gene in S.pneumoniae R6 = spr0906; identified by match to protein family HMM PF01297; adhesion lipoprotein 898975..899892 Streptococcus pneumoniae D39 4441027 YP_816370.1 CDS phtD NC_008533.1 899900 902461 D equivalent gene in S.pneumoniae TIGR4 = SP1003; equivalent gene in S.pneumoniae R6 = spr0907; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein D 899900..902461 Streptococcus pneumoniae D39 4442509 YP_816371.1 CDS phtE NC_008533.1 902671 905790 D equivalent gene in S.pneumoniae TIGR4 = SP1004; equivalent gene in S.pneumoniae R6 = spr0908; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein E 902671..905790 Streptococcus pneumoniae D39 4443073 YP_816372.1 CDS SPD_0893 NC_008533.1 907590 908219 D equivalent gene in S.pneumoniae TIGR4 = SP1007; equivalent gene in S.pneumoniae R6 = spr0912; hypothetical protein 907590..908219 Streptococcus pneumoniae D39 4442065 YP_816373.1 CDS pepT NC_008533.1 908262 909482 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(908262..909482) Streptococcus pneumoniae D39 4441097 YP_816374.1 CDS hemH NC_008533.1 909637 910731 D equivalent gene in S.pneumoniae TIGR4 = SP1009; equivalent gene in S.pneumoniae R6 = spr0914; identified by match to protein family HMM PF00762; match to protein family HMM TIGR00109; ferrochelatase 909637..910731 Streptococcus pneumoniae D39 4442347 YP_816375.1 CDS mscL NC_008533.1 910773 911150 R equivalent gene in S.pneumoniae TIGR4 = SP1010; equivalent gene in S.pneumoniae R6 = spr0915 Protein encodes a channel which opens in response to a membrane stretch force. Probably serves as an osmotic gauge. Carboxy terminus tends to be more divergent across species with a high degree of sequence conservation found at the N-terminus; identified by match to protein family HMM PF01741; match to protein family HMM TIGR00220; large conductance mechanosensitive channel protein MscL complement(910773..911150) Streptococcus pneumoniae D39 4442840 YP_816376.1 CDS SPD_0897 NC_008533.1 911232 911663 R equivalent gene in S.pneumoniae TIGR4 = SP1011; equivalent gene in S.pneumoniae R6 = spr0916; identified by match to protein family HMM PF04138; GtrA family protein complement(911232..911663) Streptococcus pneumoniae D39 4441967 YP_816377.1 CDS SPD_0898 NC_008533.1 911786 912295 D equivalent gene in S.pneumoniae TIGR4 = SP1012; equivalent gene in S.pneumoniae R6 = spr0917; identified by match to protein family HMM PF06177; hypothetical protein 911786..912295 Streptococcus pneumoniae D39 4441302 YP_816378.1 CDS asd NC_008533.1 912810 913886 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 912810..913886 Streptococcus pneumoniae D39 4441663 YP_816379.1 CDS dapA NC_008533.1 913942 914877 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 913942..914877 Streptococcus pneumoniae D39 4441518 YP_816380.1 CDS trmE NC_008533.1 914924 916297 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(914924..916297) Streptococcus pneumoniae D39 4442168 YP_816381.1 CDS xylH NC_008533.1 916434 916616 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(916434..916616) Streptococcus pneumoniae D39 4441622 YP_816382.1 CDS tdk NC_008533.1 916739 917338 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 916739..917338 Streptococcus pneumoniae D39 4441646 YP_816383.1 CDS SPD_0905 NC_008533.1 917328 917807 D equivalent gene in S.pneumoniae TIGR4 = SP1019; equivalent gene in S.pneumoniae R6 = spr0923; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 917328..917807 Streptococcus pneumoniae D39 4442526 YP_816384.1 CDS prfA NC_008533.1 917817 918896 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 917817..918896 Streptococcus pneumoniae D39 4441867 YP_816385.1 CDS hemK NC_008533.1 918896 919735 D equivalent gene in S.pneumoniae TIGR4 = SP1021; equivalent gene in S.pneumoniae R6 = spr0925; identified by match to protein family HMM PF05175; match to protein family HMM TIGR00536; HemK protein 918896..919735 Streptococcus pneumoniae D39 4441856 YP_816386.1 CDS SPD_0908 NC_008533.1 919719 920321 D equivalent gene in S.pneumoniae TIGR4 = SP1022; equivalent gene in S.pneumoniae R6 = spr0926; identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; Sua5/YciO/YrdC/YwlC family protein 919719..920321 Streptococcus pneumoniae D39 4442931 YP_816387.1 CDS SPD_0909 NC_008533.1 920323 920754 D equivalent gene in S.pneumoniae TIGR4 = SP1023; equivalent gene in S.pneumoniae R6 = spr0927; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 920323..920754 Streptococcus pneumoniae D39 4441624 YP_816388.1 CDS glyA NC_008533.1 920816 922072 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 920816..922072 Streptococcus pneumoniae D39 4441989 YP_816389.1 CDS SPD_0911 NC_008533.1 922047 923054 D equivalent gene in S.pneumoniae TIGR4 = SP1025; equivalent gene in S.pneumoniae R6 = spr0929; hypothetical protein 922047..923054 Streptococcus pneumoniae D39 4441135 YP_816390.1 CDS pvaA NC_008533.1 923054 923668 D equivalent gene in S.pneumoniae TIGR4 = SP1026; equivalent gene in S.pneumoniae R6 = spr0930; hypothetical protein 923054..923668 Streptococcus pneumoniae D39 4442196 YP_816391.1 CDS SPD_0913 NC_008533.1 923742 924716 D equivalent gene in S.pneumoniae TIGR4 = SP1027; equivalent gene in S.pneumoniae R6 = spr0931; identified by match to protein family HMM PF06207; hypothetical protein 923742..924716 Streptococcus pneumoniae D39 4442081 YP_816392.1 CDS rumA-1 NC_008533.1 924790 926421 D equivalent gene in S.pneumoniae TIGR4 = SP1029; equivalent gene in S.pneumoniae R6 = spr0932; identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 924790..926421 Streptococcus pneumoniae D39 4442854 YP_816393.1 CDS SPD_0915 NC_008533.1 927770 928795 D equivalent gene in S.pneumoniae TIGR4 = SP1032; equivalent gene in S.pneumoniae R6 = spr0934; identified by match to protein family HMM PF01497; iron-compound ABC transporter iron compound-binding protein 927770..928795 Streptococcus pneumoniae D39 4441843 YP_816394.1 CDS SPD_0916 NC_008533.1 928785 929792 D equivalent gene in S.pneumoniae TIGR4 = SP1033; equivalent gene in S.pneumoniae R6 = spr0935; identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 928785..929792 Streptococcus pneumoniae D39 4442935 YP_816395.1 CDS SPD_0917 NC_008533.1 929792 930799 D equivalent gene in S.pneumoniae TIGR4 = SP1034; equivalent gene in S.pneumoniae R6 = spr0936; identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 929792..930799 Streptococcus pneumoniae D39 4442343 YP_816396.1 CDS SPD_0918 NC_008533.1 930799 931593 D equivalent gene in S.pneumoniae TIGR4 = SP1035; equivalent gene in S.pneumoniae R6 = spr0938; identified by match to protein family HMM PF00005; iron-compound ABC transporter ATP-binding protein 930799..931593 Streptococcus pneumoniae D39 4441296 YP_816397.1 CDS SPD_0919 NC_008533.1 932495 932650 D equivalent gene in S.pneumoniae TIGR4 = SP1038; equivalent gene in S.pneumoniae R6 = spr0940; hypothetical protein 932495..932650 Streptococcus pneumoniae D39 4442923 YP_816398.1 CDS SPD_0920 NC_008533.1 933334 933495 D equivalent gene in S.pneumoniae TIGR4 = SP1039; equivalent gene in S.pneumoniae R6 = spr0941; hypothetical protein 933334..933495 Streptococcus pneumoniae D39 4441336 YP_816399.1 CDS SPD_0921 NC_008533.1 933587 935266 D equivalent gene in S.pneumoniae TIGR4 = SP1040; equivalent gene in S.pneumoniae R6 = spr0942; identified by match to protein family HMM PF00239; match to protein family HMM PF07508; site-specific recombinase, resolvase family protein 933587..935266 Streptococcus pneumoniae D39 4441075 YP_816400.1 CDS SPD_0922 NC_008533.1 935489 936100 D equivalent gene in S.pneumoniae TIGR4 = SP1041; equivalent gene in S.pneumoniae R6 = spr0943; hypothetical protein 935489..936100 Streptococcus pneumoniae D39 4442447 YP_816401.1 CDS SPD_0923 NC_008533.1 936413 936610 D equivalent gene in S.pneumoniae TIGR4 = SP1042; equivalent gene in S.pneumoniae R6 = spr0944; hypothetical protein 936413..936610 Streptococcus pneumoniae D39 4441102 YP_816402.1 CDS SPD_0924 NC_008533.1 936672 937487 D equivalent gene in S.pneumoniae TIGR4 = SP1043; equivalent gene in S.pneumoniae R6 = spr0945; hypothetical protein 936672..937487 Streptococcus pneumoniae D39 4442002 YP_816403.1 CDS SPD_0925 NC_008533.1 937487 938341 D equivalent gene in S.pneumoniae TIGR4 = SP1044; equivalent gene in S.pneumoniae R6 = spr0946; identified by match to protein family HMM PF03747; hydrolase 937487..938341 Streptococcus pneumoniae D39 4442521 YP_816404.1 CDS SPD_0926 NC_008533.1 938453 939337 D equivalent gene in S.pneumoniae TIGR4 = SP1045; equivalent gene in S.pneumoniae R6 = spr0947; identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147; hypothetical protein 938453..939337 Streptococcus pneumoniae D39 4441896 YP_816405.1 CDS nplT NC_008533.1 939476 941239 D equivalent gene in S.pneumoniae R6 = spr0948; identified by match to protein family HMM PF00128; match to protein family HMM PF02903; neopullulanase 939476..941239 Streptococcus pneumoniae D39 4442332 YP_816406.1 CDS SPD_0928 NC_008533.1 941325 941642 D equivalent gene in S.pneumoniae TIGR4 = SP1047; equivalent gene in S.pneumoniae R6 = spr0949; hypothetical protein 941325..941642 Streptococcus pneumoniae D39 4442261 YP_816407.1 CDS SPD_0929 NC_008533.1 941688 941969 D equivalent gene in S.pneumoniae TIGR4 = SP1048; equivalent gene in S.pneumoniae R6 = spr0950; hypothetical protein 941688..941969 Streptococcus pneumoniae D39 4441386 YP_816408.1 CDS SPD_0930 NC_008533.1 942414 942890 D equivalent gene in S.pneumoniae TIGR4 = SP1050; equivalent gene in S.pneumoniae R6 = spr0951; identified by match to protein family HMM PF01381; transcriptional regulator 942414..942890 Streptococcus pneumoniae D39 4441401 YP_816409.1 CDS SPD_0931 NC_008533.1 942890 943651 D equivalent gene in S.pneumoniae TIGR4 = SP1051; equivalent gene in S.pneumoniae R6 = spr0952; identified by match to protein family HMM PF06414; hypothetical protein 942890..943651 Streptococcus pneumoniae D39 4442876 YP_816410.1 CDS SPD_0932 NC_008533.1 943679 944455 D equivalent gene in S.pneumoniae TIGR4 = SP1052; equivalent gene in S.pneumoniae R6 = spr0953; hypothetical protein 943679..944455 Streptococcus pneumoniae D39 4441430 YP_816411.1 CDS SPD_0933 NC_008533.1 944383 944835 D equivalent gene in S.pneumoniae TIGR4 = SP1053; equivalent gene in S.pneumoniae R6 = spr0954; hypothetical protein 944383..944835 Streptococcus pneumoniae D39 4442970 YP_816412.1 CDS SPD_0934 NC_008533.1 945667 946026 D equivalent gene in S.pneumoniae R6 = spr0955; Tn5252, ORF 10 protein 945667..946026 Streptococcus pneumoniae D39 4441309 YP_816413.1 CDS SPD_0935 NC_008533.1 946036 946365 D equivalent gene in S.pneumoniae R6 = spr0956; identified by match to protein family HMM PF05713; Tn5252, ORF 9 protein 946036..946365 Streptococcus pneumoniae D39 4442346 YP_816414.1 CDS SPD_0936 NC_008533.1 946388 947005 D equivalent gene in S.pneumoniae R6 = spr0957; identified by match to protein family HMM PF03432; Tn5252, relaxase 946388..947005 Streptococcus pneumoniae D39 4441467 YP_816415.1 CDS SPD_0938 NC_008533.1 947686 948273 D equivalent gene in S.pneumoniae R6 = spr0959; hypothetical protein 947686..948273 Streptococcus pneumoniae D39 4442413 YP_816416.1 CDS SPD_0939 NC_008533.1 948318 949172 R equivalent gene in S.pneumoniae R6 = spr0960; identified by match to protein family HMM TIGR01716; transcriptional activator, Rgg/GadR/MutR family protein complement(948318..949172) Streptococcus pneumoniae D39 4441594 YP_816417.1 CDS SPD_0940 NC_008533.1 949424 950719 D equivalent gene in S.pneumoniae R6 = spr0961; identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase 949424..950719 Streptococcus pneumoniae D39 4442545 YP_816418.1 CDS SPD_0941 NC_008533.1 950721 951329 D equivalent gene in S.pneumoniae R6 = spr0962; hypothetical protein 950721..951329 Streptococcus pneumoniae D39 4441263 YP_816419.1 CDS SPD_0942 NC_008533.1 951339 952121 D equivalent gene in S.pneumoniae R6 = spr0963; identified by match to protein family HMM PF01261; hypothetical protein 951339..952121 Streptococcus pneumoniae D39 4442655 YP_816420.1 CDS SPD_0943 NC_008533.1 952144 954036 D equivalent gene in S.pneumoniae R6 = spr0964; hypothetical protein 952144..954036 Streptococcus pneumoniae D39 4442352 YP_816421.1 CDS SPD_0944 NC_008533.1 954065 955171 D equivalent gene in S.pneumoniae R6 = spr0965; hypothetical protein 954065..955171 Streptococcus pneumoniae D39 4442641 YP_816422.1 CDS SPD_0945 NC_008533.1 955179 956489 D equivalent gene in S.pneumoniae R6 = spr0966; identified by match to protein family HMM PF00501; AMP-binding protein 955179..956489 Streptococcus pneumoniae D39 4443082 YP_816423.1 CDS SPD_0946 NC_008533.1 956491 957714 D This gene has a tRNA synthetase class II core domain (G, H, P, S and T) protein equivalent gene in S.pneumoniae R6 spr0967; identified by match to protein family HMM PF00587; hypothetical protein 956491..957714 Streptococcus pneumoniae D39 4441451 YP_816424.1 CDS SPD_0947 NC_008533.1 957719 958654 D equivalent gene in S.pneumoniae R6 = spr0968; hypothetical protein 957719..958654 Streptococcus pneumoniae D39 4442777 YP_816425.1 CDS SPD_0948 NC_008533.1 958669 959868 D equivalent gene in S.pneumoniae R6 = spr0969; identified by match to protein family HMM PF02655; hypothetical protein 958669..959868 Streptococcus pneumoniae D39 4442010 YP_816426.1 CDS SPD_0949 NC_008533.1 959932 960531 D equivalent gene in S.pneumoniae R6 = spr0970; identified by match to protein family HMM PF00132; hexapeptide repeat-containing transferase 959932..960531 Streptococcus pneumoniae D39 4441701 YP_816427.1 CDS SPD_0950 NC_008533.1 960914 962125 D equivalent gene in S.pneumoniae R6 = spr0971; identified by match to protein family HMM PF07690; transporter major facilitator family protein 960914..962125 Streptococcus pneumoniae D39 4442896 YP_816428.1 CDS SPD_0951 NC_008533.1 962784 963005 D equivalent gene in S.pneumoniae R6 = spr0972; identified by match to protein family HMM PF01381; hypothetical protein 962784..963005 Streptococcus pneumoniae D39 4441342 YP_816429.1 CDS SPD_0952 NC_008533.1 963907 965136 D equivalent gene in S.pneumoniae TIGR4 = SP1067; equivalent gene in S.pneumoniae R6 = spr0973; identified by match to protein family HMM PF01098; cell division protein FtsW 963907..965136 Streptococcus pneumoniae D39 4441817 YP_816430.1 CDS ppc NC_008533.1 965156 967852 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 965156..967852 Streptococcus pneumoniae D39 4441700 YP_816431.1 CDS SPD_0954 NC_008533.1 968235 969269 D equivalent gene in S.pneumoniae TIGR4 = SP1069; equivalent gene in S.pneumoniae R6 = spr0975; identified by match to protein family HMM PF04392; hypothetical protein 968235..969269 Streptococcus pneumoniae D39 4441894 YP_816432.1 CDS SPD_0955 NC_008533.1 969338 970204 D equivalent gene in S.pneumoniae TIGR4 = SP1070; equivalent gene in S.pneumoniae R6 = spr0976; identified by match to protein family HMM PF02653; amino acid or sugar ABC transporter permease 969338..970204 Streptococcus pneumoniae D39 4442672 YP_816433.1 CDS SPD_0956 NC_008533.1 970201 970959 D equivalent gene in S.pneumoniae TIGR4 = SP1071; equivalent gene in S.pneumoniae R6 = spr0977; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 970201..970959 Streptococcus pneumoniae D39 4442983 YP_816434.1 CDS dnaG NC_008533.1 971049 972809 D synthesizes RNA primers at the replication forks; DNA primase 971049..972809 Streptococcus pneumoniae D39 4442736 YP_816435.1 CDS rpoD NC_008533.1 972812 973921 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 972812..973921 Streptococcus pneumoniae D39 4441427 YP_816436.1 CDS SPD_0959 NC_008533.1 973935 974264 D equivalent gene in S.pneumoniae TIGR4 = SP1074; equivalent gene in S.pneumoniae R6 = spr0980; identified by match to protein family HMM PF01883; hypothetical protein 973935..974264 Streptococcus pneumoniae D39 4442191 YP_816437.1 CDS cpoA NC_008533.1 974298 975422 D equivalent gene in S.pneumoniae TIGR4 = SP1075; equivalent gene in S.pneumoniae R6 = spr0981; identified by match to protein family HMM PF00534; glycosyl transferase CpoA 974298..975422 Streptococcus pneumoniae D39 4442276 YP_816438.1 CDS SPD_0961 NC_008533.1 975438 976763 D equivalent gene in S.pneumoniae TIGR4 = SP1076; equivalent gene in S.pneumoniae R6 = spr0982; identified by match to protein family HMM PF00534; group 1 glycosyl transferase 975438..976763 Streptococcus pneumoniae D39 4442649 YP_816439.1 CDS SPD_0962 NC_008533.1 976794 976970 D equivalent gene in S.pneumoniae TIGR4 = SP1077; equivalent gene in S.pneumoniae R6 = spr0983; identified by match to protein family HMM PF04024; hypothetical protein 976794..976970 Streptococcus pneumoniae D39 4443007 YP_816440.1 CDS SPD_0963 NC_008533.1 977029 977163 D equivalent gene in S.pneumoniae TIGR4 = SP1078; hypothetical protein 977029..977163 Streptococcus pneumoniae D39 4442839 YP_816441.1 CDS obgE NC_008533.1 977227 978537 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 977227..978537 Streptococcus pneumoniae D39 4442664 YP_816442.1 CDS SPD_0965 NC_008533.1 978547 978705 D equivalent gene in S.pneumoniae TIGR4 = SP1080; equivalent gene in S.pneumoniae R6 = spr0985; hypothetical protein 978547..978705 Streptococcus pneumoniae D39 4441585 YP_816443.1 CDS murA-1 NC_008533.1 981327 982586 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 981327..982586 Streptococcus pneumoniae D39 4441381 YP_816444.1 CDS SPD_0968 NC_008533.1 982602 983153 D equivalent gene in S.pneumoniae TIGR4 = SP1082; equivalent gene in S.pneumoniae R6 = spr0990; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 982602..983153 Streptococcus pneumoniae D39 4443006 YP_816445.1 CDS SPD_0969 NC_008533.1 983146 984423 D equivalent gene in S.pneumoniae TIGR4 = SP1083; equivalent gene in S.pneumoniae R6 = spr0991; identified by match to protein family HMM PF00571; match to protein family HMM PF03061; match to protein family HMM PF07085; hypothetical protein 983146..984423 Streptococcus pneumoniae D39 4442377 YP_816446.1 CDS map NC_008533.1 984439 985299 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 984439..985299 Streptococcus pneumoniae D39 4443077 YP_816447.1 CDS SPD_0971 NC_008533.1 985680 986078 D equivalent gene in S.pneumoniae TIGR4 = SP1310; equivalent gene in S.pneumoniae R6 = spr0993; IS1381, transposase OrfA 985680..986078 Streptococcus pneumoniae D39 4442483 YP_816448.1 CDS SPD_0972 NC_008533.1 986093 986482 D IS1381, transposase OrfB 986093..986482 Streptococcus pneumoniae D39 4442110 YP_816449.1 CDS pcrA NC_008533.1 986673 988964 D equivalent gene in S.pneumoniae TIGR4 = SP1087; equivalent gene in S.pneumoniae R6 = spr0995; identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073; ATP-dependent DNA helicase PcrA 986673..988964 Streptococcus pneumoniae D39 4442251 YP_816450.1 CDS radC NC_008533.1 989007 989687 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 989007..989687 Streptococcus pneumoniae D39 4442389 YP_816451.1 CDS SPD_0974 NC_008533.1 989684 990373 R equivalent gene in S.pneumoniae TIGR4 = SP1089; equivalent gene in S.pneumoniae R6 = spr0997; identified by match to protein family HMM PF00117; match to protein family HMM PF07722; class I glutamine amidotransferase complement(989684..990373) Streptococcus pneumoniae D39 4441960 YP_816452.1 CDS SPD_0976 NC_008533.1 990391 991032 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(990391..991032) Streptococcus pneumoniae D39 4442478 YP_816453.1 CDS SPD_0977 NC_008533.1 991115 991366 R equivalent gene in S.pneumoniae TIGR4 = SP1092; equivalent gene in S.pneumoniae R6 = spr0999; hypothetical protein complement(991115..991366) Streptococcus pneumoniae D39 4442615 YP_816454.1 CDS SPD_0978 NC_008533.1 991338 991685 R equivalent gene in S.pneumoniae TIGR4 = SP1093; equivalent gene in S.pneumoniae R6 = spr1000; hypothetical protein complement(991338..991685) Streptococcus pneumoniae D39 4442883 YP_816455.1 CDS SPD_0979 NC_008533.1 991690 992805 R equivalent gene in S.pneumoniae TIGR4 = SP1094; equivalent gene in S.pneumoniae R6 = spr1001; identified by match to protein family HMM PF00266; class V aminotransferase complement(991690..992805) Streptococcus pneumoniae D39 4441180 YP_816456.1 CDS prs2 NC_008533.1 992815 993774 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(992815..993774) Streptococcus pneumoniae D39 4442349 YP_816457.1 CDS SPD_0981 NC_008533.1 993887 994456 R equivalent gene in S.pneumoniae TIGR4 = SP1096; equivalent gene in S.pneumoniae R6 = spr1003; identified by match to protein family HMM PF01928; hypothetical protein complement(993887..994456) Streptococcus pneumoniae D39 4441470 YP_816458.1 CDS SPD_0982 NC_008533.1 994584 995255 D equivalent gene in S.pneumoniae TIGR4 = SP1097; equivalent gene in S.pneumoniae R6 = spr1004 This protein has been crystalized; identified by match to protein family HMM PF04607; pyrophosphokinase family protein 994584..995255 Streptococcus pneumoniae D39 4442405 YP_816459.1 CDS ppnK NC_008533.1 995239 996057 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 995239..996057 Streptococcus pneumoniae D39 4441101 YP_816460.1 CDS SPD_0984 NC_008533.1 996054 996950 D equivalent gene in S.pneumoniae TIGR4 = SP1099; equivalent gene in S.pneumoniae R6 = spr1006; identified by match to protein family HMM PF00849; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase, RluD subfamily protein 996054..996950 Streptococcus pneumoniae D39 4442836 YP_816461.1 CDS eutD NC_008533.1 996994 997968 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 996994..997968 Streptococcus pneumoniae D39 4442579 YP_816462.1 CDS SPD_0987 NC_008533.1 999729 1000028 R equivalent gene in S.pneumoniae TIGR4 = SP1102; equivalent gene in S.pneumoniae R6 = spr1010; identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein complement(999729..1000028) Streptococcus pneumoniae D39 4442388 YP_816463.1 CDS SPD_0988 NC_008533.1 1000430 1001134 D equivalent gene in S.pneumoniae TIGR4 = SP1104; equivalent gene in S.pneumoniae R6 = spr1011; identified by match to protein family HMM PF06912; hypothetical protein 1000430..1001134 Streptococcus pneumoniae D39 4442134 YP_816464.1 CDS rplU NC_008533.1 1001316 1001630 D equivalent gene in S.pneumoniae TIGR4 = SP1105; equivalent gene in S.pneumoniae R6 = spr1012; identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 1001316..1001630 Streptococcus pneumoniae D39 4442297 YP_816465.1 CDS SPD_0990 NC_008533.1 1001646 1001990 D equivalent gene in S.pneumoniae TIGR4 = SP1106; equivalent gene in S.pneumoniae R6 = spr1013; identified by match to protein family HMM PF04327; hypothetical protein 1001646..1001990 Streptococcus pneumoniae D39 4441287 YP_816466.1 CDS rpmA NC_008533.1 1002007 1002300 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1002007..1002300 Streptococcus pneumoniae D39 4441188 YP_816467.1 CDS SPD_0992 NC_008533.1 1002646 1002816 R equivalent gene in S.pneumoniae TIGR4 = SP1108; equivalent gene in S.pneumoniae R6 = spr1015; hypothetical protein complement(1002646..1002816) Streptococcus pneumoniae D39 4442972 YP_816468.1 CDS SPD_0993 NC_008533.1 1002788 1002916 R equivalent gene in S.pneumoniae TIGR4 = SP1109; hypothetical protein complement(1002788..1002916) Streptococcus pneumoniae D39 4441480 YP_816469.1 CDS ribF NC_008533.1 1003253 1004170 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1003253..1004170 Streptococcus pneumoniae D39 4441879 YP_816470.1 CDS SPD_0995 NC_008533.1 1004263 1005111 R equivalent gene in S.pneumoniae TIGR4 = SP1111; equivalent gene in S.pneumoniae R6 = spr1018; identified by match to protein family HMM PF02588; hypothetical protein complement(1004263..1005111) Streptococcus pneumoniae D39 4441584 YP_816471.1 CDS SPD_0996 NC_008533.1 1005253 1006092 D equivalent gene in S.pneumoniae TIGR4 = SP1112; equivalent gene in S.pneumoniae R6 = spr1019; identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; DegV family protein 1005253..1006092 Streptococcus pneumoniae D39 4441852 YP_816472.1 CDS hup NC_008533.1 1006198 1006473 D equivalent gene in S.pneumoniae TIGR4 = SP1113; equivalent gene in S.pneumoniae R6 = spr1020; identified by match to protein family HMM PF00216; DNA-binding protein HU 1006198..1006473 Streptococcus pneumoniae D39 4441465 YP_816473.1 CDS SPD_0998 NC_008533.1 1006899 1008800 D equivalent gene in S.pneumoniae TIGR4 = SP1114; equivalent gene in S.pneumoniae R6 = spr1021; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1006899..1008800 Streptococcus pneumoniae D39 4442227 YP_816474.1 CDS SPD_0999 NC_008533.1 1008803 1009666 D equivalent gene in S.pneumoniae TIGR4 = SP1115; equivalent gene in S.pneumoniae R6 = spr1022; identified by match to protein family HMM TIGR01716; transcriptional regulator MutR 1008803..1009666 Streptococcus pneumoniae D39 4442235 YP_816475.1 CDS SPD_1000 NC_008533.1 1009746 1010924 D equivalent gene in S.pneumoniae TIGR4 = SP1116; equivalent gene in S.pneumoniae R6 = spr1023; identified by match to protein family HMM PF07690; transporter major facilitator family protein 1009746..1010924 Streptococcus pneumoniae D39 4441440 YP_816476.1 CDS ligA NC_008533.1 1011017 1012975 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1011017..1012975 Streptococcus pneumoniae D39 4442940 YP_816477.1 CDS pulA NC_008533.1 1013087 1015366 D equivalent gene in S.pneumoniae TIGR4 = SP1118; equivalent gene in S.pneumoniae R6 = spr1025; identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; pullulanase 1013087..1015366 Streptococcus pneumoniae D39 4441162 YP_816478.1 CDS SPD_1003 NC_008533.1 1015718 1015891 R equivalent gene in S.pneumoniae R6 = spr1027; hypothetical protein complement(1015718..1015891) Streptococcus pneumoniae D39 4442556 YP_816479.1 CDS gapN NC_008533.1 1015910 1017334 D equivalent gene in S.pneumoniae TIGR4 = SP1119; equivalent gene in S.pneumoniae R6 = spr1028; identified by match to protein family HMM PF00171; glyceraldehyde-3-phosphate dehydrogenase 1015910..1017334 Streptococcus pneumoniae D39 4443074 YP_816480.1 CDS glgB NC_008533.1 1017799 1019727 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 1017799..1019727 Streptococcus pneumoniae D39 4442375 YP_816481.1 CDS glgC NC_008533.1 1019717 1020859 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1019717..1020859 Streptococcus pneumoniae D39 4442809 YP_816482.1 CDS glgD NC_008533.1 1020849 1021988 D equivalent gene in S.pneumoniae TIGR4 = SP1123; equivalent gene in S.pneumoniae R6 = spr1031; identified by match to protein family HMM PF00483; match to protein family HMM TIGR02092; glucose-1-phosphate adenylyltransferase, GlgD subunit 1020849..1021988 Streptococcus pneumoniae D39 4441771 YP_816483.1 CDS glgA NC_008533.1 1021985 1023418 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1021985..1023418 Streptococcus pneumoniae D39 4443012 YP_816484.1 CDS SPD_1011 NC_008533.1 1024131 1025246 D equivalent gene in S.pneumoniae TIGR4 = SP1126; equivalent gene in S.pneumoniae R6 = spr1034; identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase 1024131..1025246 Streptococcus pneumoniae D39 4441167 YP_816485.1 CDS SPD_1010 NC_008533.1 1025243 1025689 R equivalent gene in S.pneumoniae TIGR4 = SP1127; equivalent gene in S.pneumoniae R6 = spr1035; identified by match to protein family HMM PF07997; hypothetical protein complement(1025243..1025689) Streptococcus pneumoniae D39 4441830 YP_816486.1 CDS eno NC_008533.1 1025853 1027157 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1025853..1027157 Streptococcus pneumoniae D39 4442279 YP_816487.1 CDS SPD_1013 NC_008533.1 1027295 1027741 R equivalent gene in S.pneumoniae TIGR4 = SP1147; identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family protein complement(1027295..1027741) Streptococcus pneumoniae D39 4441393 YP_816488.1 CDS SPD_1014 NC_008533.1 1028138 1028488 R equivalent gene in S.pneumoniae TIGR4 = SP0299; equivalent gene in S.pneumoniae R6 = spr1038 In TIGR4 this gene is annotated as a truncation; however in R6 there are numerous near perfect copies as well as copies with a slightly longer version with a different end that is not present in either R6 or TIGR4 This indicates it may still function as a transposase; identified by match to protein family HMM PF01710; IS630-Spn1, transposase Orf1 complement(1028138..1028488) Streptococcus pneumoniae D39 4441543 YP_816489.1 CDS rexB NC_008533.1 1028989 1032288 D RexAB system found in Gram positive bacteria appears to fulfill the biological roles of RecBCD found in Gram negative bacteria. equivalent gene in S.pneumoniae TIGR4 = SP1151; equivalent gene in S.pneumoniae R6 = spr1039; identified by match to protein family HMM TIGR02774; ATP-dependent exonuclease RexB 1028989..1032288 Streptococcus pneumoniae D39 4442911 YP_816490.1 CDS rexA NC_008533.1 1032285 1035935 D RexAB system found in Gram positive bacteria appears to fulfill the biological roles of RecBCD found in Gram negative bacteria. equivalent gene in S.pneumoniae TIGR4 = SP1152; equivalent gene in S.pneumoniae R6 = spr1040; identified by match to protein family HMM PF00580; match to protein family HMM TIGR02785; exonuclease RexA 1032285..1035935 Streptococcus pneumoniae D39 4441291 YP_816491.1 CDS SPD_1017 NC_008533.1 1036105 1037283 D equivalent gene in S.pneumoniae TIGR4 = SP1153; equivalent gene in S.pneumoniae R6 = spr1041; hypothetical protein 1036105..1037283 Streptococcus pneumoniae D39 4441958 YP_816492.1 CDS iga NC_008533.1 1037492 1043383 D equivalent gene in S.pneumoniae R6 = spr1042; identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; immunoglobulin A1 protease 1037492..1043383 Streptococcus pneumoniae D39 4442828 YP_816493.1 CDS rbgA NC_008533.1 1043842 1044693 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1043842..1044693 Streptococcus pneumoniae D39 4441293 YP_816494.1 CDS rnhB NC_008533.1 1044680 1045459 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1044680..1045459 Streptococcus pneumoniae D39 4442425 YP_816495.1 CDS SPD_1021 NC_008533.1 1045475 1047025 D equivalent gene in S.pneumoniae TIGR4 = SP1157; equivalent gene in S.pneumoniae R6 = spr1045; identified by match to protein family HMM PF00654; match to protein family HMM PF02080; voltage-gated chloride channel family protein 1045475..1047025 Streptococcus pneumoniae D39 4441862 YP_816496.1 CDS SPD_1022 NC_008533.1 1047218 1047331 R equivalent gene in S.pneumoniae TIGR4 = SP1158; hypothetical protein complement(1047218..1047331) Streptococcus pneumoniae D39 4442915 YP_816497.1 CDS xerS NC_008533.1 1047609 1048679 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1047609..1048679 Streptococcus pneumoniae D39 4442838 YP_816498.1 CDS SPD_1024 NC_008533.1 1048752 1049741 R equivalent gene in S.pneumoniae TIGR4 = SP1160; equivalent gene in S.pneumoniae R6 = spr1047; identified by match to protein family HMM PF03099; match to protein family HMM TIGR00545; lipoate-protein ligase complement(1048752..1049741) Streptococcus pneumoniae D39 4442301 YP_816499.1 CDS lpdA NC_008533.1 1049805 1051490 R equivalent gene in S.pneumoniae TIGR4 = SP1161; equivalent gene in S.pneumoniae R6 = spr1048; identified by match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350; dihydrolipoamide dehydrogenase complement(1049805..1051490) Streptococcus pneumoniae D39 4441333 YP_816500.1 CDS SPD_1026 NC_008533.1 1051554 1052597 R unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase complement(1051554..1052597) Streptococcus pneumoniae D39 4442477 YP_816501.1 CDS SPD_1027 NC_008533.1 1052815 1053807 R equivalent gene in S.pneumoniae TIGR4 = SP1163; equivalent gene in S.pneumoniae R6 = spr1050; identified by match to protein family HMM PF02779; match to protein family HMM PF02780; acetoin dehydrogenase, E1 component subunit beta complement(1052815..1053807) Streptococcus pneumoniae D39 4442291 YP_816502.1 CDS acoA NC_008533.1 1053823 1054791 R equivalent gene in S.pneumoniae TIGR4 = SP1164; equivalent gene in S.pneumoniae R6 = spr1051; identified by match to protein family HMM PF00676; TPP-dependent acetoin dehydrogenase subunit alpha complement(1053823..1054791) Streptococcus pneumoniae D39 4441464 YP_816503.1 CDS SPD_1029 NC_008533.1 1054945 1056306 R equivalent gene in S.pneumoniae TIGR4 = SP1166; equivalent gene in S.pneumoniae R6 = spr1052; identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; MATE efflux family protein complement(1054945..1056306) Streptococcus pneumoniae D39 4441954 YP_816504.1 CDS pyrC NC_008533.1 1056591 1057859 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1056591..1057859) Streptococcus pneumoniae D39 4442857 YP_816505.1 CDS mutX NC_008533.1 1057872 1058336 R equivalent gene in S.pneumoniae TIGR4 = SP1168; equivalent gene in S.pneumoniae R6 = spr1054; identified by match to protein family HMM PF00293; Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) complement(1057872..1058336) Streptococcus pneumoniae D39 4441251 YP_816506.1 CDS ung NC_008533.1 1058346 1058999 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(1058346..1058999) Streptococcus pneumoniae D39 4442309 YP_816507.1 CDS SPD_1033 NC_008533.1 1059135 1059782 R equivalent gene in S.pneumoniae TIGR4 = SP1170; equivalent gene in S.pneumoniae R6 = spr1056; hypothetical protein complement(1059135..1059782) Streptococcus pneumoniae D39 4441170 YP_816508.1 CDS SPD_1034 NC_008533.1 1059796 1060509 R equivalent gene in S.pneumoniae TIGR4 = SP1171; equivalent gene in S.pneumoniae R6 = spr1057; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254; hydrolase complement(1059796..1060509) Streptococcus pneumoniae D39 4442574 YP_816509.1 CDS SPD_1035 NC_008533.1 1060967 1061125 R equivalent gene in S.pneumoniae TIGR4 = SP1173; equivalent gene in S.pneumoniae R6 = spr1058; hypothetical protein complement(1060967..1061125) Streptococcus pneumoniae D39 4441528 YP_816510.1 CDS SPD_1036 NC_008533.1 1061195 1061347 R equivalent gene in S.pneumoniae R6 = spr1059; hypothetical protein complement(1061195..1061347) Streptococcus pneumoniae D39 4442069 YP_816511.1 CDS SPD_1037 NC_008533.1 1061769 1064303 R equivalent gene in S.pneumoniae R6 = spr1060; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein complement(1061769..1064303) Streptococcus pneumoniae D39 4441531 YP_816512.1 CDS phpA NC_008533.1 1064461 1066911 R equivalent gene in S.pneumoniae TIGR4 = SP1175; equivalent gene in S.pneumoniae R6 = spr1061; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein A complement(1064461..1066911) Streptococcus pneumoniae D39 4441988 YP_816513.1 CDS ptsI NC_008533.1 1067166 1068899 R equivalent gene in S.pneumoniae TIGR4 = SP1176; equivalent gene in S.pneumoniae R6 = spr1062; identified by match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; phosphoenolpyruvate-protein phosphotransferase complement(1067166..1068899) Streptococcus pneumoniae D39 4441380 YP_816514.1 CDS ptsH NC_008533.1 1068905 1069168 R equivalent gene in S.pneumoniae TIGR4 = SP1177; equivalent gene in S.pneumoniae R6 = spr1063; identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphocarrier protein HPr complement(1068905..1069168) Streptococcus pneumoniae D39 4442339 YP_816515.1 CDS nrdH NC_008533.1 1069519 1069737 D equivalent gene in S.pneumoniae TIGR4 = SP1178; equivalent gene in S.pneumoniae R6 = spr1064; identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin-like protein NrdH 1069519..1069737 Streptococcus pneumoniae D39 4442017 YP_816516.1 CDS nrdE NC_008533.1 1069818 1071977 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1069818..1071977 Streptococcus pneumoniae D39 4442530 YP_816517.1 CDS nrdF NC_008533.1 1072165 1073127 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1072165..1073127 Streptococcus pneumoniae D39 4441876 YP_816518.1 CDS lacR2 NC_008533.1 1073309 1074070 D equivalent gene in S.pneumoniae TIGR4 = SP1182; equivalent gene in S.pneumoniae R6 = spr1067; identified by match to protein family HMM PF00455; match to protein family HMM PF08220; lactose phosphotransferase system repressor 1073309..1074070 Streptococcus pneumoniae D39 4442936 YP_816519.1 CDS SPD_1045 NC_008533.1 1074340 1074525 R hypothetical protein complement(1074340..1074525) Streptococcus pneumoniae D39 4441245 YP_816520.1 CDS lacG-2 NC_008533.1 1074568 1075974 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(1074568..1075974) Streptococcus pneumoniae D39 4442459 YP_816521.1 CDS lacE-2 NC_008533.1 1076183 1077874 R equivalent gene in S.pneumoniae TIGR4 = SP1185; equivalent gene in S.pneumoniae R6 = spr1070; identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00394; match to protein family HMM TIGR00410; match to protein family HMM TIGR00853; PTS system lactose-specific transporter subunit IIBC complement(1076183..1077874) Streptococcus pneumoniae D39 4441210 YP_816522.1 CDS lacF-2 NC_008533.1 1077874 1078191 R equivalent gene in S.pneumoniae TIGR4 = SP1186; equivalent gene in S.pneumoniae R6 = spr1071; identified by match to protein family HMM PF02255; match to protein family HMM TIGR00823; PTS system lactose-specific transporter subunit IIA complement(1077874..1078191) Streptococcus pneumoniae D39 4441229 YP_816523.1 CDS lacT NC_008533.1 1078227 1079063 R equivalent gene in S.pneumoniae TIGR4 = SP1187; equivalent gene in S.pneumoniae R6 = spr1072; identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LacT complement(1078227..1079063) Streptococcus pneumoniae D39 4441809 YP_816524.1 CDS lacD NC_008533.1 1079297 1080277 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1079297..1080277) Streptococcus pneumoniae D39 4443030 YP_816525.1 CDS lacC NC_008533.1 1080279 1081208 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(1080279..1081208) Streptococcus pneumoniae D39 4441699 YP_816526.1 CDS lacB NC_008533.1 1081219 1081734 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1081219..1081734) Streptococcus pneumoniae D39 4442367 YP_816527.1 CDS lacA NC_008533.1 1081765 1082190 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(1081765..1082190) Streptococcus pneumoniae D39 4441388 YP_816528.1 CDS SPD_1054 NC_008533.1 1082348 1082692 R equivalent gene in S.pneumoniae TIGR4 = SP1194; equivalent gene in S.pneumoniae R6 = spr1077; hypothetical protein complement(1082348..1082692) Streptococcus pneumoniae D39 4442085 YP_816529.1 CDS SPD_1057 NC_008533.1 1083671 1083973 R equivalent gene in S.pneumoniae TIGR4 = SP1197; equivalent gene in S.pneumoniae R6 = spr1080; PTS system transporter subunit IIB complement(1083671..1083973) Streptococcus pneumoniae D39 4441051 YP_816530.1 CDS SPD_1059 NC_008533.1 1084667 1084819 D hypothetical protein 1084667..1084819 Streptococcus pneumoniae D39 4442240 YP_816531.1 CDS lepA NC_008533.1 1084900 1086723 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1084900..1086723) Streptococcus pneumoniae D39 4441488 YP_816532.1 CDS SPD_1061 NC_008533.1 1086802 1087530 R equivalent gene in S.pneumoniae TIGR4 = SP1201; equivalent gene in S.pneumoniae R6 = spr1083; identified by match to protein family HMM PF00149; serine/threonine protein phosphatase complement(1086802..1087530) Streptococcus pneumoniae D39 4442937 YP_816533.1 CDS recN NC_008533.1 1087532 1089199 R equivalent gene in S.pneumoniae TIGR4 = SP1202; equivalent gene in S.pneumoniae R6 = spr1084; identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; DNA repair protein RecN complement(1087532..1089199) Streptococcus pneumoniae D39 4442157 YP_816534.1 CDS SPD_1063 NC_008533.1 1089206 1089637 R equivalent gene in S.pneumoniae TIGR4 = SP1203; equivalent gene in S.pneumoniae R6 = spr1085; identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional regulator of arginine metabolism expression complement(1089206..1089637) Streptococcus pneumoniae D39 4441032 YP_816535.1 CDS SPD_1064 NC_008533.1 1089630 1090445 R equivalent gene in S.pneumoniae TIGR4 = SP1204; equivalent gene in S.pneumoniae R6 = spr1086; identified by match to protein family HMM PF01479; match to protein family HMM PF01728; match to protein family HMM TIGR00478; hemolysin A complement(1089630..1090445) Streptococcus pneumoniae D39 4442162 YP_816536.1 CDS ispA NC_008533.1 1090438 1091313 R equivalent gene in S.pneumoniae TIGR4 = SP1205; equivalent gene in S.pneumoniae R6 = spr1087; identified by match to protein family HMM PF00348; geranyltranstransferase complement(1090438..1091313) Streptococcus pneumoniae D39 4441508 YP_816537.1 CDS xseB NC_008533.1 1091310 1091522 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1091310..1091522) Streptococcus pneumoniae D39 4443075 YP_816538.1 CDS xseA NC_008533.1 1091500 1092840 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1091500..1092840) Streptococcus pneumoniae D39 4441185 YP_816539.1 CDS udk NC_008533.1 1092968 1093606 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1092968..1093606) Streptococcus pneumoniae D39 4442822 YP_816540.1 CDS SPD_1069 NC_008533.1 1093714 1094016 R equivalent gene in S.pneumoniae TIGR4 = SP1210; equivalent gene in S.pneumoniae R6 = spr1091; hypothetical protein complement(1093714..1094016) Streptococcus pneumoniae D39 4441255 YP_816541.1 CDS truB NC_008533.1 1094257 1095135 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1094257..1095135) Streptococcus pneumoniae D39 4441016 YP_816542.1 CDS SPD_1071 NC_008533.1 1095236 1098421 R equivalent gene in S.pneumoniae R6 = spr1093; hypothetical protein complement(1095236..1098421) Streptococcus pneumoniae D39 4441274 YP_816543.1 CDS SPD_1072 NC_008533.1 1098433 1099707 R equivalent gene in S.pneumoniae TIGR4 = SP1213; equivalent gene in S.pneumoniae R6 = spr1094; hypothetical protein complement(1098433..1099707) Streptococcus pneumoniae D39 4441348 YP_816544.1 CDS SPD_1073 NC_008533.1 1099803 1100918 R equivalent gene in S.pneumoniae R6 = spr1095; identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326; O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase complement(1099803..1100918) Streptococcus pneumoniae D39 4442203 YP_816545.1 CDS SPD_1074 NC_008533.1 1100940 1101062 R similar to a domain of the O-acetylhomoserine sulfhydrylase characterized in Leptospira meyeri. equivalent gene in S.pneumoniae R6 = spr1096; hypothetical protein complement(1100940..1101062) Streptococcus pneumoniae D39 4442127 YP_816546.1 CDS SPD_1075 NC_008533.1 1101210 1102007 R equivalent gene in S.pneumoniae TIGR4 = SP1215; equivalent gene in S.pneumoniae R6 = spr1097; identified by match to protein family HMM PF01226; transporter FNT family protein complement(1101210..1102007) Streptococcus pneumoniae D39 4442514 YP_816547.1 CDS srtA NC_008533.1 1102251 1102994 R equivalent gene in S.pneumoniae TIGR4 = SP1218; equivalent gene in S.pneumoniae R6 = spr1098; identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase complement(1102251..1102994) Streptococcus pneumoniae D39 4442999 YP_816548.1 CDS gyrA NC_008533.1 1102994 1105462 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(1102994..1105462) Streptococcus pneumoniae D39 4442457 YP_816549.1 CDS ldh NC_008533.1 1105656 1106642 D Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1105656..1106642 Streptococcus pneumoniae D39 4442741 YP_816550.1 CDS SPD_1079 NC_008533.1 1107028 1110282 R equivalent gene in S.pneumoniae TIGR4 = SP1221; equivalent gene in S.pneumoniae R6 = spr1101; identified by match to protein family HMM PF04851; type II restriction endonuclease complement(1107028..1110282) Streptococcus pneumoniae D39 4443037 YP_816551.1 CDS SPD_1080 NC_008533.1 1110447 1112318 R equivalent gene in S.pneumoniae TIGR4 = SP1222; equivalent gene in S.pneumoniae R6 = spr1102; identified by match to protein family HMM PF07669; type II restriction endonuclease complement(1110447..1112318) Streptococcus pneumoniae D39 4441679 YP_816552.1 CDS SPD_1081 NC_008533.1 1112393 1112647 R equivalent gene in S.pneumoniae TIGR4 = SP1223; equivalent gene in S.pneumoniae R6 = spr1103; identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; hypothetical protein complement(1112393..1112647) Streptococcus pneumoniae D39 4441469 YP_816553.1 CDS SPD_1082 NC_008533.1 1112649 1112951 R equivalent gene in S.pneumoniae TIGR4 = SP1224; equivalent gene in S.pneumoniae R6 = spr1104; hypothetical protein complement(1112649..1112951) Streptococcus pneumoniae D39 4442357 YP_816554.1 CDS vicX NC_008533.1 1112982 1113791 R equivalent gene in S.pneumoniae TIGR4 = SP1225; equivalent gene in S.pneumoniae R6 = spr1105; identified by match to protein family HMM PF00753; vicX protein complement(1112982..1113791) Streptococcus pneumoniae D39 4442200 YP_816555.1 CDS SPD_1084 NC_008533.1 1113793 1115142 R equivalent gene in S.pneumoniae TIGR4 = SP1226; equivalent gene in S.pneumoniae R6 = spr1106; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229; sensory box sensor histidine kinase complement(1113793..1115142) Streptococcus pneumoniae D39 4441065 YP_816556.1 CDS SPD_1085 NC_008533.1 1115135 1115839 R equivalent gene in S.pneumoniae TIGR4 = SP1227; equivalent gene in S.pneumoniae R6 = spr1107; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator complement(1115135..1115839) Streptococcus pneumoniae D39 4441330 YP_816557.1 CDS mutY NC_008533.1 1115894 1117069 R equivalent gene in S.pneumoniae TIGR4 = SP1228; equivalent gene in S.pneumoniae R6 = spr1108; identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; A/G-specific adenine glycosylase complement(1115894..1117069) Streptococcus pneumoniae D39 4442450 YP_816558.1 CDS fhs NC_008533.1 1117398 1119068 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1117398..1119068) Streptococcus pneumoniae D39 4442359 YP_816559.1 CDS coaB NC_008533.1 1119298 1119987 D equivalent gene in S.pneumoniae TIGR4 = SP1230; equivalent gene in S.pneumoniae R6 = spr1110; identified by match to protein family HMM PF04127; match to protein family HMM TIGR02114; phosphopantothenate--cysteine ligase 1119298..1119987 Streptococcus pneumoniae D39 4441133 YP_816560.1 CDS coaC NC_008533.1 1119999 1120550 D decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1119999..1120550 Streptococcus pneumoniae D39 4442804 YP_816561.1 CDS SPD_1090 NC_008533.1 1120534 1121097 D equivalent gene in S.pneumoniae TIGR4 = SP1232; equivalent gene in S.pneumoniae R6 = spr1112; hypothetical protein 1120534..1121097 Streptococcus pneumoniae D39 4442990 YP_816562.1 CDS SPD_1091 NC_008533.1 1121379 1121906 D equivalent gene in S.pneumoniae TIGR4 = SP1233; equivalent gene in S.pneumoniae R6 = spr1113; hypothetical protein 1121379..1121906 Streptococcus pneumoniae D39 4441678 YP_816563.1 CDS SPD_1093 NC_008533.1 1121918 1122433 D equivalent gene in S.pneumoniae R6 = spr1114; identified by match to protein family HMM PF02829; transcriptional regulator, biotin repressor family protein 1121918..1122433 Streptococcus pneumoniae D39 4441582 YP_816564.1 CDS SPD_1092 NC_008533.1 1122430 1122897 R equivalent gene in S.pneumoniae TIGR4 = SP1235; equivalent gene in S.pneumoniae R6 = spr1115; identified by match to protein family HMM PF00293; MutT/nudix family protein complement(1122430..1122897) Streptococcus pneumoniae D39 4441653 YP_816565.1 CDS SPD_1094 NC_008533.1 1122971 1123459 R equivalent gene in S.pneumoniae TIGR4 = SP1236; equivalent gene in S.pneumoniae R6 = spr1116; identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1122971..1123459) Streptococcus pneumoniae D39 4441264 YP_816566.1 CDS SPD_1095 NC_008533.1 1123425 1123988 R equivalent gene in S.pneumoniae TIGR4 = SP1237; equivalent gene in S.pneumoniae R6 = spr1117; hypothetical protein complement(1123425..1123988) Streptococcus pneumoniae D39 4442374 YP_816567.1 CDS uvrB NC_008533.1 1123998 1125986 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1123998..1125986) Streptococcus pneumoniae D39 4443015 YP_816568.1 CDS SPD_1097 NC_008533.1 1126063 1127016 R equivalent gene in S.pneumoniae TIGR4 = SP1240; equivalent gene in S.pneumoniae R6 = spr1119; identified by match to protein family HMM PF02517; hypothetical protein complement(1126063..1127016) Streptococcus pneumoniae D39 4441563 YP_816569.1 CDS SPD_1098 NC_008533.1 1127189 1129354 D equivalent gene in S.pneumoniae TIGR4 = SP1241; equivalent gene in S.pneumoniae R6 = spr1120; identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter amino acid-binding protein/permease 1127189..1129354 Streptococcus pneumoniae D39 4442047 YP_816570.1 CDS SPD_1099 NC_008533.1 1129354 1130094 D equivalent gene in S.pneumoniae TIGR4 = SP1242; equivalent gene in S.pneumoniae R6 = spr1121; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 1129354..1130094 Streptococcus pneumoniae D39 4443083 YP_816571.1 CDS zwf NC_008533.1 1130243 1131730 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1130243..1131730 Streptococcus pneumoniae D39 4441677 YP_816572.1 CDS ftsY NC_008533.1 1131776 1133053 R equivalent gene in S.pneumoniae TIGR4 = SP1244; equivalent gene in S.pneumoniae R6 = spr1123; identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064; signal recognition particle-docking protein FtsY complement(1131776..1133053) Streptococcus pneumoniae D39 4441605 YP_816573.1 CDS SPD_1102 NC_008533.1 1133057 1133875 R equivalent gene in S.pneumoniae TIGR4 = SP1245; equivalent gene in S.pneumoniae R6 = spr1124; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1133057..1133875) Streptococcus pneumoniae D39 4441285 YP_816574.1 CDS SPD_1103 NC_008533.1 1133875 1134669 R equivalent gene in S.pneumoniae TIGR4 = SP1246; equivalent gene in S.pneumoniae R6 = spr1125; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1133875..1134669) Streptococcus pneumoniae D39 4441995 YP_816575.1 CDS smc NC_008533.1 1134666 1138205 R equivalent gene in S.pneumoniae TIGR4 = SP1247; equivalent gene in S.pneumoniae R6 = spr1126; identified by match to protein family HMM PF02463; match to protein family HMM PF06470; match to protein family HMM TIGR00650; match to protein family HMM TIGR02168; chromosome segregation protein SMC complement(1134666..1138205) Streptococcus pneumoniae D39 4442786 YP_816576.1 CDS rnc NC_008533.1 1138196 1138894 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(1138196..1138894) Streptococcus pneumoniae D39 4441922 YP_816577.1 CDS guaC NC_008533.1 1139212 1140198 R equivalent gene in S.pneumoniae TIGR4 = SP1249; equivalent gene in S.pneumoniae R6 = spr1128; identified by match to protein family HMM PF00478; match to protein family HMM TIGR01306; guanosine 5'-monophosphate oxidoreductase complement(1139212..1140198) Streptococcus pneumoniae D39 4441775 YP_816578.1 CDS SPD_1108 NC_008533.1 1140373 1141689 R equivalent gene in S.pneumoniae TIGR4 = SP1250; equivalent gene in S.pneumoniae R6 = spr1129; hypothetical protein complement(1140373..1141689) Streptococcus pneumoniae D39 4442098 YP_816579.1 CDS SPD_1109 NC_008533.1 1141676 1143607 R equivalent gene in S.pneumoniae TIGR4 = SP1251; equivalent gene in S.pneumoniae R6 = spr1130; endonuclease complement(1141676..1143607) Streptococcus pneumoniae D39 4441214 YP_816580.1 CDS SPD_1110 NC_008533.1 1143771 1143932 R equivalent gene in S.pneumoniae TIGR4 = SP1252; equivalent gene in S.pneumoniae R6 = spr1131; hypothetical protein complement(1143771..1143932) Streptococcus pneumoniae D39 4441368 YP_816581.1 CDS SPD_1111 NC_008533.1 1143922 1144095 R equivalent gene in S.pneumoniae TIGR4 = SP1253; equivalent gene in S.pneumoniae R6 = spr1132; hypothetical protein complement(1143922..1144095) Streptococcus pneumoniae D39 4441500 YP_816582.1 CDS SPD_1112 NC_008533.1 1144195 1144338 R equivalent gene in S.pneumoniae TIGR4 = SP1254; hypothetical protein complement(1144195..1144338) Streptococcus pneumoniae D39 4442618 YP_816583.1 CDS SPD_1113 NC_008533.1 1144557 1144916 R equivalent gene in S.pneumoniae TIGR4 = SP1255; equivalent gene in S.pneumoniae R6 = spr1133; hypothetical protein complement(1144557..1144916) Streptococcus pneumoniae D39 4441202 YP_816584.1 CDS SPD_1114 NC_008533.1 1145014 1145127 D hypothetical protein 1145014..1145127 Streptococcus pneumoniae D39 4441341 YP_816585.1 CDS leuB NC_008533.1 1145186 1146223 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(1145186..1146223) Streptococcus pneumoniae D39 4442132 YP_816586.1 CDS SPD_1117 NC_008533.1 1147348 1148004 R equivalent gene in S.pneumoniae TIGR4 = SP1259; equivalent gene in S.pneumoniae R6 = spr1138; identified by match to protein family HMM PF04237; hypothetical protein complement(1147348..1148004) Streptococcus pneumoniae D39 4442435 YP_816587.1 CDS cutC NC_008533.1 1148048 1148680 R equivalent gene in S.pneumoniae TIGR4 = SP1260; equivalent gene in S.pneumoniae R6 = spr1139; identified by match to protein family HMM PF03932; copper homeostasis protein CutC complement(1148048..1148680) Streptococcus pneumoniae D39 4442143 YP_816588.1 CDS SPD_1119 NC_008533.1 1148773 1149132 R equivalent gene in S.pneumoniae TIGR4 = SP1261; equivalent gene in S.pneumoniae R6 = spr1140; identified by match to protein family HMM PF04304; hypothetical protein complement(1148773..1149132) Streptococcus pneumoniae D39 4442539 YP_816589.1 CDS topA NC_008533.1 1149238 1151325 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(1149238..1151325) Streptococcus pneumoniae D39 4442393 YP_816590.1 CDS SPD_1121 NC_008533.1 1151492 1152535 R equivalent gene in S.pneumoniae TIGR4 = SP1264; equivalent gene in S.pneumoniae R6 = spr1142; identified by match to protein family HMM PF04087; hypothetical protein complement(1151492..1152535) Streptococcus pneumoniae D39 4442730 YP_816591.1 CDS SPD_1122 NC_008533.1 1153425 1154273 R equivalent gene in S.pneumoniae TIGR4 = SP1266; equivalent gene in S.pneumoniae R6 = spr1144; identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA processing protein DprA complement(1153425..1154273) Streptococcus pneumoniae D39 4442966 YP_816592.1 CDS licC NC_008533.1 1154369 1155058 R equivalent gene in S.pneumoniae TIGR4 = SP1267; equivalent gene in S.pneumoniae R6 = spr1145; identified by match to protein family HMM PF00483; CTP:phosphocholine cytidylyltransferase complement(1154369..1155058) Streptococcus pneumoniae D39 4442550 YP_816593.1 CDS licB NC_008533.1 1155070 1155948 R equivalent gene in S.pneumoniae TIGR4 = SP1268; equivalent gene in S.pneumoniae R6 = spr1146; identified by match to protein family HMM PF00892; protein LicB complement(1155070..1155948) Streptococcus pneumoniae D39 4441045 YP_816594.1 CDS pck NC_008533.1 1155938 1156807 R equivalent gene in S.pneumoniae TIGR4 = SP1269; equivalent gene in S.pneumoniae R6 = spr1147; identified by match to protein family HMM PF01633; match to protein family HMM PF01636; choline kinase complement(1155938..1156807) Streptococcus pneumoniae D39 4442720 YP_816595.1 CDS SPD_1126 NC_008533.1 1156824 1157846 R equivalent gene in S.pneumoniae TIGR4 = SP1270; equivalent gene in S.pneumoniae R6 = spr1148; zinc-containing alcohol dehydrogenase complement(1156824..1157846) Streptococcus pneumoniae D39 4442798 YP_816596.1 CDS ispD NC_008533.1 1157851 1158558 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1157851..1158558) Streptococcus pneumoniae D39 4441914 YP_816597.1 CDS SPD_1128 NC_008533.1 1158894 1160381 D equivalent gene in S.pneumoniae TIGR4 = SP1272; equivalent gene in S.pneumoniae R6 = spr1150; identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein 1158894..1160381 Streptococcus pneumoniae D39 4441521 YP_816598.1 CDS licD1 NC_008533.1 1160391 1161194 D equivalent gene in S.pneumoniae TIGR4 = SP1273; equivalent gene in S.pneumoniae R6 = spr1151; identified by match to protein family HMM PF04991; phosphotransferase LicD1 1160391..1161194 Streptococcus pneumoniae D39 4442139 YP_816599.1 CDS licD2 NC_008533.1 1161196 1162005 D equivalent gene in S.pneumoniae TIGR4 = SP1274; equivalent gene in S.pneumoniae R6 = spr1152; identified by match to protein family HMM PF04991; phosphotransferase LicD2 1161196..1162005 Streptococcus pneumoniae D39 4442426 YP_816600.1 CDS carB NC_008533.1 1162280 1165456 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(1162280..1165456) Streptococcus pneumoniae D39 4442622 YP_816601.1 CDS carA NC_008533.1 1165769 1166848 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(1165769..1166848) Streptococcus pneumoniae D39 4441609 YP_816602.1 CDS pyrB NC_008533.1 1166898 1167821 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit complement(1166898..1167821) Streptococcus pneumoniae D39 4442176 YP_816603.1 CDS pyrR NC_008533.1 1167840 1168361 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase complement(1167840..1168361) Streptococcus pneumoniae D39 4441450 YP_816604.1 CDS nth NC_008533.1 1168572 1169201 R equivalent gene in S.pneumoniae TIGR4 = SP1279; equivalent gene in S.pneumoniae R6 = spr1157; identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083; endonuclease III complement(1168572..1169201) Streptococcus pneumoniae D39 4441695 YP_816605.1 CDS SPD_1136 NC_008533.1 1169201 1169743 R equivalent gene in S.pneumoniae TIGR4 = SP1280; equivalent gene in S.pneumoniae R6 = spr1158; identified by match to protein family HMM PF02620; COG1399; hypothetical protein complement(1169201..1169743) Streptococcus pneumoniae D39 4442272 YP_816606.1 CDS SPD_1137 NC_008533.1 1170469 1172028 D equivalent gene in S.pneumoniae TIGR4 = SP1282; equivalent gene in S.pneumoniae R6 = spr1161; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1170469..1172028 Streptococcus pneumoniae D39 4441828 YP_816607.1 CDS htpX NC_008533.1 1172177 1173076 R metalloprotease; heat shock protein HtpX complement(1172177..1173076) Streptococcus pneumoniae D39 4442766 YP_816608.1 CDS lemA NC_008533.1 1173078 1173638 R equivalent gene in S.pneumoniae TIGR4 = SP1284; equivalent gene in S.pneumoniae R6 = spr1163; identified by match to protein family HMM PF04011; LemA protein complement(1173078..1173638) Streptococcus pneumoniae D39 4441507 YP_816609.1 CDS gidB NC_008533.1 1173732 1174445 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1173732..1174445 Streptococcus pneumoniae D39 4442151 YP_816610.1 CDS uraA NC_008533.1 1174797 1176080 D equivalent gene in S.pneumoniae TIGR4 = SP1286; equivalent gene in S.pneumoniae R6 = spr1165; identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil-xanthine permease 1174797..1176080 Streptococcus pneumoniae D39 4441694 YP_816611.1 CDS ffh NC_008533.1 1176275 1177846 R equivalent gene in S.pneumoniae TIGR4 = SP1287; equivalent gene in S.pneumoniae R6 = spr1166; identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959; signal recognition particle protein complement(1176275..1177846) Streptococcus pneumoniae D39 4441332 YP_816612.1 CDS SPD_1143 NC_008533.1 1177858 1178190 R equivalent gene in S.pneumoniae TIGR4 = SP1288; equivalent gene in S.pneumoniae R6 = spr1167; identified by match to protein family HMM PF04297; match to protein family HMM PF04967; DNA-binding protein complement(1177858..1178190) Streptococcus pneumoniae D39 4442725 YP_816613.1 CDS SPD_1144 NC_008533.1 1178281 1178658 R equivalent gene in S.pneumoniae TIGR4 = SP1289; equivalent gene in S.pneumoniae R6 = spr1168; hypothetical protein complement(1178281..1178658) Streptococcus pneumoniae D39 4442961 YP_816614.1 CDS SPD_1145 NC_008533.1 1178730 1180034 D equivalent gene in S.pneumoniae TIGR4 = SP1290; equivalent gene in S.pneumoniae R6 = spr1169; identified by match to protein family HMM PF01966; hypothetical protein 1178730..1180034 Streptococcus pneumoniae D39 4442689 YP_816615.1 CDS SPD_1146 NC_008533.1 1180047 1180853 D equivalent gene in S.pneumoniae TIGR4 = SP1291; equivalent gene in S.pneumoniae R6 = spr1170; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1180047..1180853 Streptococcus pneumoniae D39 4442033 YP_816616.1 CDS rplS NC_008533.1 1181021 1181368 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1181021..1181368) Streptococcus pneumoniae D39 4441142 YP_816617.1 CDS crcB1 NC_008533.1 1181487 1181816 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1181487..1181816) Streptococcus pneumoniae D39 4441069 YP_816618.1 CDS crcB2 NC_008533.1 1181810 1182184 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1181810..1182184) Streptococcus pneumoniae D39 4442190 YP_816619.1 CDS SPD_1151 NC_008533.1 1182181 1182447 R equivalent gene in S.pneumoniae TIGR4 = SP1296; equivalent gene in S.pneumoniae R6 = spr1174; identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805; hypothetical protein complement(1182181..1182447) Streptococcus pneumoniae D39 4443053 YP_816620.1 CDS fld NC_008533.1 1182563 1183006 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(1182563..1183006) Streptococcus pneumoniae D39 4441982 YP_816621.1 CDS SPD_1153 NC_008533.1 1183110 1184045 D equivalent gene in S.pneumoniae TIGR4 = SP1298; equivalent gene in S.pneumoniae R6 = spr1176; identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 1183110..1184045 Streptococcus pneumoniae D39 4442976 YP_816622.1 CDS rpmE2 NC_008533.1 1184141 1184383 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1184141..1184383 Streptococcus pneumoniae D39 4442420 YP_816623.1 CDS SPD_1155 NC_008533.1 1184440 1185018 R equivalent gene in S.pneumoniae TIGR4 = SP1300; equivalent gene in S.pneumoniae R6 = spr1178; hypothetical protein complement(1184440..1185018) Streptococcus pneumoniae D39 4442452 YP_816624.1 CDS SPD_1156 NC_008533.1 1184993 1185997 R equivalent gene in S.pneumoniae R6 = spr1179; identified by match to protein family HMM PF04261; match to protein family HMM TIGR01413; Dyp-type peroxidase family protein complement(1184993..1185997) Streptococcus pneumoniae D39 4441686 YP_816625.1 CDS SPD_1157 NC_008533.1 1186049 1186315 R equivalent gene in S.pneumoniae TIGR4 = SP0733; equivalent gene in S.pneumoniae R6 = spr1180; hypothetical protein complement(1186049..1186315) Streptococcus pneumoniae D39 4442167 YP_816626.1 CDS gdhA NC_008533.1 1187003 1188349 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1187003..1188349 Streptococcus pneumoniae D39 4442918 YP_816627.1 CDS SPD_1159 NC_008533.1 1188845 1189015 R equivalent gene in S.pneumoniae TIGR4 = SP1307; equivalent gene in S.pneumoniae R6 = spr1182; hypothetical protein complement(1188845..1189015) Streptococcus pneumoniae D39 4442776 YP_816628.1 CDS SPD_1160 NC_008533.1 1189028 1189669 R equivalent gene in S.pneumoniae TIGR4 = SP1308; equivalent gene in S.pneumoniae R6 = spr1183; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1189028..1189669) Streptococcus pneumoniae D39 4442617 YP_816629.1 CDS SPD_1161 NC_008533.1 1189941 1190378 D equivalent gene in S.pneumoniae R6 = spr1184; hypothetical protein 1189941..1190378 Streptococcus pneumoniae D39 4442517 YP_816630.1 CDS SPD_1162 NC_008533.1 1190669 1190872 R This gene is a fragement of the glucokinase genes 3' end. equivalent gene in S.pneumoniae R6 = spr1185; hypothetical protein complement(1190669..1190872) Streptococcus pneumoniae D39 4442323 YP_816631.1 CDS SPD_1163 NC_008533.1 1190890 1191621 R equivalent gene in S.pneumoniae TIGR4 = SP1676; equivalent gene in S.pneumoniae R6 = spr1186; identified by match to protein family HMM PF00701; N-acetylneuraminate lyase complement(1190890..1191621) Streptococcus pneumoniae D39 4442489 YP_816632.1 CDS cdd-2 NC_008533.1 1191839 1192246 R equivalent gene in S.pneumoniae R6 = spr1188; identified by match to protein family HMM PF00383; match to protein family HMM TIGR01354; cytidine deaminase complement(1191839..1192246) Streptococcus pneumoniae D39 4443069 YP_816633.1 CDS SPD_1165 NC_008533.1 1192534 1193022 R equivalent gene in S.pneumoniae R6 = spr1189; hypothetical protein complement(1192534..1193022) Streptococcus pneumoniae D39 4442654 YP_816634.1 CDS SPD_1166 NC_008533.1 1193027 1194436 R equivalent gene in S.pneumoniae R6 = spr1190; hypothetical protein complement(1193027..1194436) Streptococcus pneumoniae D39 4441120 YP_816635.1 CDS SPD_1167 NC_008533.1 1194446 1196428 R equivalent gene in S.pneumoniae R6 = spr1191; identified by match to protein family HMM PF00005; match to protein family HMM TIGR01727; ABC transporter ATP-binding protein complement(1194446..1196428) Streptococcus pneumoniae D39 4441448 YP_816636.1 CDS SPD_1168 NC_008533.1 1196441 1197292 R equivalent gene in S.pneumoniae R6 = spr1192; identified by match to protein family HMM PF00528; oligopeptide ABC transporter pemease protein complement(1196441..1197292) Streptococcus pneumoniae D39 4441671 YP_816637.1 CDS SPD_1169 NC_008533.1 1197309 1198259 R equivalent gene in S.pneumoniae R6 = spr1193; identified by match to protein family HMM PF00528; oligopeptide ABC transporter permease complement(1197309..1198259) Streptococcus pneumoniae D39 4443060 YP_816638.1 CDS SPD_1170 NC_008533.1 1198369 1199997 R equivalent gene in S.pneumoniae R6 = spr1194; identified by match to protein family HMM PF00496; oligopeptide ABC transporteroligopeptide-binding protein complement(1198369..1199997) Streptococcus pneumoniae D39 4441081 YP_816639.1 CDS SPD_1171 NC_008533.1 1200079 1201002 R equivalent gene in S.pneumoniae R6 = spr1195; identified by match to protein family HMM PF07646; hypothetical protein complement(1200079..1201002) Streptococcus pneumoniae D39 4441422 YP_816640.1 CDS nanE-2 NC_008533.1 1201026 1201724 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1201026..1201724) Streptococcus pneumoniae D39 4443010 YP_816641.1 CDS SPD_1174 NC_008533.1 1202617 1202838 R equivalent gene in S.pneumoniae R6 = spr1199; hypothetical protein complement(1202617..1202838) Streptococcus pneumoniae D39 4441813 YP_816642.1 CDS SPD_1175 NC_008533.1 1203902 1205221 R equivalent gene in S.pneumoniae TIGR4 = SP1340; equivalent gene in S.pneumoniae R6 = spr1201; hypothetical protein complement(1203902..1205221) Streptococcus pneumoniae D39 4441607 YP_816643.1 CDS SPD_1176 NC_008533.1 1205224 1205964 R equivalent gene in S.pneumoniae TIGR4 = SP1341; equivalent gene in S.pneumoniae R6 = spr1202; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1205224..1205964) Streptococcus pneumoniae D39 4441702 YP_816644.1 CDS SPD_1177 NC_008533.1 1205979 1207586 R equivalent gene in S.pneumoniae TIGR4 = SP1342; equivalent gene in S.pneumoniae R6 = spr1203; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; drug efflux ABC transporter ATP-binding protein/permease complement(1205979..1207586) Streptococcus pneumoniae D39 4441893 YP_816645.1 CDS SPD_1178 NC_008533.1 1207583 1209523 R equivalent gene in S.pneumoniae TIGR4 = SP1343; equivalent gene in S.pneumoniae R6 = spr1204; identified by match to protein family HMM PF00326; prolyl oligopeptidase family protein complement(1207583..1209523) Streptococcus pneumoniae D39 4442384 YP_816646.1 CDS SPD_1179 NC_008533.1 1209556 1212165 R equivalent gene in S.pneumoniae TIGR4 = SP1344; equivalent gene in S.pneumoniae R6 = spr1205; identified by match to protein family HMM PF05147; hypothetical protein complement(1209556..1212165) Streptococcus pneumoniae D39 4442549 YP_816647.1 CDS SPD_1180 NC_008533.1 1212683 1213270 R equivalent gene in S.pneumoniae TIGR4 = SP1346; equivalent gene in S.pneumoniae R6 = spr1206; identified by match to protein family HMM PF02517; CAAX amino terminal protease family protein complement(1212683..1213270) Streptococcus pneumoniae D39 4441436 YP_816648.1 CDS SPD_1181 NC_008533.1 1213363 1213506 R equivalent gene in S.pneumoniae TIGR4 = SP1333; hypothetical protein complement(1213363..1213506) Streptococcus pneumoniae D39 4441578 YP_816649.1 CDS SPD_1182 NC_008533.1 1213519 1213899 R equivalent gene in S.pneumoniae TIGR4 = SP1348; equivalent gene in S.pneumoniae R6 = spr1207; hypothetical protein complement(1213519..1213899) Streptococcus pneumoniae D39 4442123 YP_816650.1 CDS SPD_1183 NC_008533.1 1213954 1214232 R equivalent gene in S.pneumoniae TIGR4 = SP1349; equivalent gene in S.pneumoniae R6 = spr1208; hypothetical protein complement(1213954..1214232) Streptococcus pneumoniae D39 4442578 YP_816651.1 CDS SPD_1184 NC_008533.1 1214240 1214494 R equivalent gene in S.pneumoniae TIGR4 = SP1350; equivalent gene in S.pneumoniae R6 = spr1209; identified by match to protein family HMM PF06970; hypothetical protein complement(1214240..1214494) Streptococcus pneumoniae D39 4442787 YP_816652.1 CDS SPD_1185 NC_008533.1 1214491 1214664 R equivalent gene in S.pneumoniae R6 = spr1210; hypothetical protein complement(1214491..1214664) Streptococcus pneumoniae D39 4442050 YP_816653.1 CDS SPD_1186 NC_008533.1 1214640 1214822 D hypothetical protein 1214640..1214822 Streptococcus pneumoniae D39 4442700 YP_816654.1 CDS rplL NC_008533.1 1214852 1215220 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1214852..1215220) Streptococcus pneumoniae D39 4442399 YP_816655.1 CDS rplJ NC_008533.1 1215296 1215796 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1215296..1215796) Streptococcus pneumoniae D39 4443054 YP_816656.1 CDS SPD_1189 NC_008533.1 1215801 1216025 D equivalent gene in S.pneumoniae R6 = spr1213; hypothetical protein 1215801..1216025 Streptococcus pneumoniae D39 4442228 YP_816657.1 CDS SPD_1190 NC_008533.1 1216046 1217305 R equivalent gene in S.pneumoniae TIGR4 = SP1356; equivalent gene in S.pneumoniae R6 = spr1214; identified by match to protein family HMM PF01979; match to protein family HMM PF07969; chlorohydrolase complement(1216046..1217305) Streptococcus pneumoniae D39 4442988 YP_816658.1 CDS SPD_1191 NC_008533.1 1217607 1219358 R equivalent gene in S.pneumoniae TIGR4 = SP1357; equivalent gene in S.pneumoniae R6 = spr1215; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1217607..1219358) Streptococcus pneumoniae D39 4441053 YP_816659.1 CDS SPD_1192 NC_008533.1 1219360 1221084 R equivalent gene in S.pneumoniae TIGR4 = SP1358; equivalent gene in S.pneumoniae R6 = spr1216; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1219360..1221084) Streptococcus pneumoniae D39 4441483 YP_816660.1 CDS msrAB1 NC_008533.1 1221142 1222080 R equivalent gene in S.pneumoniae TIGR4 = SP1359; equivalent gene in S.pneumoniae R6 = spr1217; identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; bifunctional methionine sulfoxide reductase A/B complement(1221142..1222080) Streptococcus pneumoniae D39 4442965 YP_816661.1 CDS thrB NC_008533.1 1222376 1223245 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(1222376..1223245) Streptococcus pneumoniae D39 4441912 YP_816662.1 CDS hom NC_008533.1 1223247 1224533 R catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase complement(1223247..1224533) Streptococcus pneumoniae D39 4441524 YP_816663.1 CDS mecA NC_008533.1 1224684 1225421 R enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein complement(1224684..1225421) Streptococcus pneumoniae D39 4442555 YP_816664.1 CDS SPD_1197 NC_008533.1 1225563 1226597 R equivalent gene in S.pneumoniae TIGR4 = SP1363; equivalent gene in S.pneumoniae R6 = spr1221; hypothetical protein complement(1225563..1226597) Streptococcus pneumoniae D39 4441576 YP_816665.1 CDS SPD_1198 NC_008533.1 1226626 1228059 R equivalent gene in S.pneumoniae TIGR4 = SP1364; equivalent gene in S.pneumoniae R6 = spr1222; hypothetical protein complement(1226626..1228059) Streptococcus pneumoniae D39 4442257 YP_816666.1 CDS SPD_1199 NC_008533.1 1228075 1229061 R equivalent gene in S.pneumoniae TIGR4 = SP1365; equivalent gene in S.pneumoniae R6 = spr1223; identified by match to protein family HMM PF00535; glycosyl transferase family protein complement(1228075..1229061) Streptococcus pneumoniae D39 4442271 YP_816667.1 CDS SPD_1200 NC_008533.1 1229063 1230163 R equivalent gene in S.pneumoniae TIGR4 = SP1366; equivalent gene in S.pneumoniae R6 = spr1224; identified by match to protein family HMM PF00534; glycoside hydrolase family protein complement(1229063..1230163) Streptococcus pneumoniae D39 4442096 YP_816668.1 CDS licD3 NC_008533.1 1230156 1231001 R equivalent gene in S.pneumoniae TIGR4 = SP1367; equivalent gene in S.pneumoniae R6 = spr1225; identified by match to protein family HMM PF04991; phosphotransferase LicD3 complement(1230156..1231001) Streptococcus pneumoniae D39 4442408 YP_816669.1 CDS psr NC_008533.1 1231280 1232554 R equivalent gene in S.pneumoniae TIGR4 = SP1368; equivalent gene in S.pneumoniae R6 = spr1226; identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; Psr protein complement(1231280..1232554) Streptococcus pneumoniae D39 4441477 YP_816670.1 CDS SPD_1203 NC_008533.1 1232551 1233399 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(1232551..1233399) Streptococcus pneumoniae D39 4442643 YP_816671.1 CDS aroK NC_008533.1 1233396 1233872 R equivalent gene in S.pneumoniae TIGR4 = SP1370; equivalent gene in S.pneumoniae R6 = spr1228; identified by match to protein family HMM PF01202; shikimate kinase complement(1233396..1233872) Streptococcus pneumoniae D39 4441920 YP_816672.1 CDS aroA NC_008533.1 1233865 1235148 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1233865..1235148) Streptococcus pneumoniae D39 4441387 YP_816673.1 CDS SPD_1206 NC_008533.1 1235240 1235578 R equivalent gene in S.pneumoniae TIGR4 = SP1372; equivalent gene in S.pneumoniae R6 = spr1230; identified by match to protein family HMM PF06133; hypothetical protein complement(1235240..1235578) Streptococcus pneumoniae D39 4441160 YP_816674.1 CDS tyrA NC_008533.1 1235589 1236692 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(1235589..1236692) Streptococcus pneumoniae D39 4441475 YP_816675.1 CDS aroC NC_008533.1 1236702 1237868 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1236702..1237868) Streptococcus pneumoniae D39 4441579 YP_816676.1 CDS aroB NC_008533.1 1237878 1238945 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1237878..1238945) Streptococcus pneumoniae D39 4442142 YP_816677.1 CDS aroE NC_008533.1 1238964 1239818 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1238964..1239818) Streptococcus pneumoniae D39 4441696 YP_816678.1 CDS aroD NC_008533.1 1239808 1240485 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1239808..1240485) Streptococcus pneumoniae D39 4441953 YP_816679.1 CDS SPD_1212 NC_008533.1 1240482 1241654 R equivalent gene in S.pneumoniae TIGR4 = SP1378; equivalent gene in S.pneumoniae R6 = spr1236; hypothetical protein complement(1240482..1241654) Streptococcus pneumoniae D39 4441139 YP_816680.1 CDS SPD_1213 NC_008533.1 1242332 1243966 R equivalent gene in S.pneumoniae TIGR4 = SP1380; equivalent gene in S.pneumoniae R6 = spr1237; hypothetical protein complement(1242332..1243966) Streptococcus pneumoniae D39 4442633 YP_816681.1 CDS SPD_1214 NC_008533.1 1243947 1244696 R equivalent gene in S.pneumoniae TIGR4 = SP1381; equivalent gene in S.pneumoniae R6 = spr1238; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1243947..1244696) Streptococcus pneumoniae D39 4441282 YP_816682.1 CDS amy NC_008533.1 1244874 1246328 D converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 1244874..1246328 Streptococcus pneumoniae D39 4443068 YP_816683.1 CDS alaS NC_008533.1 1246418 1249036 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1246418..1249036) Streptococcus pneumoniae D39 4442752 YP_816684.1 CDS SPD_1217 NC_008533.1 1249058 1249543 R equivalent gene in S.pneumoniae TIGR4 = SP1384; equivalent gene in S.pneumoniae R6 = spr1241; identified by match to protein family HMM PF04525; hypothetical protein complement(1249058..1249543) Streptococcus pneumoniae D39 4442484 YP_816685.1 CDS potD NC_008533.1 1250318 1251388 R equivalent gene in S.pneumoniae TIGR4 = SP1386; equivalent gene in S.pneumoniae R6 = spr1243; identified by match to protein family HMM PF01547; spermidine/putrescine ABC transporter spermidine/putrescine-binding protein complement(1250318..1251388) Streptococcus pneumoniae D39 4442604 YP_816686.1 CDS potC NC_008533.1 1251385 1252158 R equivalent gene in S.pneumoniae TIGR4 = SP1387; equivalent gene in S.pneumoniae R6 = spr1244; identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease complement(1251385..1252158) Streptococcus pneumoniae D39 4441903 YP_816687.1 CDS potH NC_008533.1 1252155 1252961 R equivalent gene in S.pneumoniae TIGR4 = SP1388; equivalent gene in S.pneumoniae R6 = spr1245; identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease complement(1252155..1252961) Streptococcus pneumoniae D39 4442904 YP_816688.1 CDS potA NC_008533.1 1252942 1254099 R equivalent gene in S.pneumoniae TIGR4 = SP1389; equivalent gene in S.pneumoniae R6 = spr1246; identified by match to protein family HMM PF00005; spermidine/putrescine ABC transporter ATP-binding protein complement(1252942..1254099) Streptococcus pneumoniae D39 4441606 YP_816689.1 CDS murB NC_008533.1 1254158 1255108 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(1254158..1255108) Streptococcus pneumoniae D39 4441024 YP_816690.1 CDS SPD_1223 NC_008533.1 1255220 1255972 R equivalent gene in S.pneumoniae TIGR4 = SP1391; equivalent gene in S.pneumoniae R6 = spr1248; hypothetical protein complement(1255220..1255972) Streptococcus pneumoniae D39 4441455 YP_816691.1 CDS budA NC_008533.1 1255982 1256713 R equivalent gene in S.pneumoniae TIGR4 = SP1392; equivalent gene in S.pneumoniae R6 = spr1249; identified by match to protein family HMM PF03306; match to protein family HMM TIGR01252; alpha-acetolactate decarboxylase complement(1255982..1256713) Streptococcus pneumoniae D39 4442183 YP_816692.1 CDS SPD_1225 NC_008533.1 1256855 1258126 D equivalent gene in S.pneumoniae TIGR4 = SP1393; equivalent gene in S.pneumoniae R6 = spr1250; identified by match to protein family HMM PF00392; hypothetical protein 1256855..1258126 Streptococcus pneumoniae D39 4441314 YP_816693.1 CDS SPD_1226 NC_008533.1 1258146 1258961 R equivalent gene in S.pneumoniae TIGR4 = SP1394; equivalent gene in S.pneumoniae R6 = spr1251; identified by match to protein family HMM PF00497; amino acid ABC transporter amino acid-binding protein complement(1258146..1258961) Streptococcus pneumoniae D39 4441233 YP_816694.1 CDS SPD_1227 NC_008533.1 1259118 1259771 R equivalent gene in S.pneumoniae TIGR4 = SP1395; equivalent gene in S.pneumoniae R6 = spr1252; identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU complement(1259118..1259771) Streptococcus pneumoniae D39 4442856 YP_816695.1 CDS SPD_1228 NC_008533.1 1259783 1260541 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1259783..1260541) Streptococcus pneumoniae D39 4441647 YP_816696.1 CDS SPD_1229 NC_008533.1 1260554 1261357 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1260554..1261357) Streptococcus pneumoniae D39 4441698 YP_816697.1 CDS SPD_1230 NC_008533.1 1261368 1262252 R equivalent gene in S.pneumoniae TIGR4 = SP1398; equivalent gene in S.pneumoniae R6 = spr1255; identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease complement(1261368..1262252) Streptococcus pneumoniae D39 4442178 YP_816698.1 CDS SPD_1231 NC_008533.1 1262242 1263159 R equivalent gene in S.pneumoniae TIGR4 = SP1399; equivalent gene in S.pneumoniae R6 = spr1256; identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease complement(1262242..1263159) Streptococcus pneumoniae D39 4442601 YP_816699.1 CDS SPD_1232 NC_008533.1 1263159 1264037 R equivalent gene in S.pneumoniae TIGR4 = SP1400; equivalent gene in S.pneumoniae R6 = spr1257; identified by match to protein family HMM PF01547; match to protein family HMM TIGR02136; phosphate ABC transporter substrate-binding protein complement(1263159..1264037) Streptococcus pneumoniae D39 4441935 YP_816700.1 CDS SPD_1233 NC_008533.1 1264611 1265915 R equivalent gene in S.pneumoniae TIGR4 = SP1402; equivalent gene in S.pneumoniae R6 = spr1259; identified by match to protein family HMM PF01189; NOL1/NOP2/sun family protein complement(1264611..1265915) Streptococcus pneumoniae D39 4443042 YP_816701.1 CDS SPD_1234 NC_008533.1 1265916 1266689 R equivalent gene in S.pneumoniae TIGR4 = SP1403; equivalent gene in S.pneumoniae R6 = spr1260; identified by match to protein family HMM PF00459; inositol monophosphatase family protein complement(1265916..1266689) Streptococcus pneumoniae D39 4441615 YP_816702.1 CDS SPD_1235 NC_008533.1 1266679 1266957 R equivalent gene in S.pneumoniae TIGR4 = SP1404; equivalent gene in S.pneumoniae R6 = spr1261; identified by match to protein family HMM PF05256; hypothetical protein complement(1266679..1266957) Streptococcus pneumoniae D39 4442946 YP_816703.1 CDS spxA NC_008533.1 1266957 1267358 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx complement(1266957..1267358) Streptococcus pneumoniae D39 4441239 YP_816704.1 CDS SPD_1237 NC_008533.1 1267568 1268185 R equivalent gene in S.pneumoniae TIGR4 = SP1406; equivalent gene in S.pneumoniae R6 = spr1263; identified by match to protein family HMM PF07314; match to protein family HMM TIGR01906; hypothetical protein complement(1267568..1268185) Streptococcus pneumoniae D39 4442900 YP_816705.1 CDS SPD_1238 NC_008533.1 1268175 1268948 R equivalent gene in S.pneumoniae TIGR4 = SP1407; equivalent gene in S.pneumoniae R6 = spr1264; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01457; match to protein family HMM TIGR01460; hydrolase complement(1268175..1268948) Streptococcus pneumoniae D39 4442329 YP_816706.1 CDS SPD_1239 NC_008533.1 1268959 1269696 R equivalent gene in S.pneumoniae TIGR4 = SP1408; equivalent gene in S.pneumoniae R6 = spr1265; identified by match to protein family HMM PF01643; acyl-ACP thioesterase complement(1268959..1269696) Streptococcus pneumoniae D39 4441763 YP_816707.1 CDS SPD_1240 NC_008533.1 1269701 1270831 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1269701..1270831) Streptococcus pneumoniae D39 4441944 YP_816708.1 CDS SPD_1241 NC_008533.1 1270915 1271304 R equivalent gene in S.pneumoniae TIGR4 = SP1410; equivalent gene in S.pneumoniae R6 = spr1267; hypothetical protein complement(1270915..1271304) Streptococcus pneumoniae D39 4441362 YP_816709.1 CDS SPD_1242 NC_008533.1 1271320 1271703 R equivalent gene in S.pneumoniae TIGR4 = SP1411; equivalent gene in S.pneumoniae R6 = spr1268; identified by match to protein family HMM PF06103; hypothetical protein complement(1271320..1271703) Streptococcus pneumoniae D39 4442460 YP_816710.1 CDS lgt NC_008533.1 1271704 1272492 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1271704..1272492) Streptococcus pneumoniae D39 4441067 YP_816711.1 CDS hprK NC_008533.1 1272485 1273420 R catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase complement(1272485..1273420) Streptococcus pneumoniae D39 4442748 YP_816712.1 CDS rpsU NC_008533.1 1273550 1273726 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1273550..1273726) Streptococcus pneumoniae D39 4441906 YP_816713.1 CDS nagB NC_008533.1 1273866 1274573 R equivalent gene in S.pneumoniae TIGR4 = SP1415; equivalent gene in S.pneumoniae R6 = spr1272; identified by match to protein family HMM PF01182; glucosamine-6-phosphate isomerase complement(1273866..1274573) Streptococcus pneumoniae D39 4441482 YP_816714.1 CDS queA NC_008533.1 1274724 1275752 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1274724..1275752 Streptococcus pneumoniae D39 4442551 YP_816715.1 CDS SPD_1248 NC_008533.1 1276301 1276690 R equivalent gene in S.pneumoniae R6 = spr1274 The R6 gene is annotated as a choline binding protein truncation (spsA-truncation); identified by match to protein family HMM PF01473; hypothetical protein complement(1276301..1276690) Streptococcus pneumoniae D39 4441849 YP_816716.1 CDS SPD_1249 NC_008533.1 1278144 1278695 R equivalent gene in S.pneumoniae TIGR4 = SP1419; equivalent gene in S.pneumoniae R6 = spr1275; identified by match to protein family HMM PF00583; acetyltransferase complement(1278144..1278695) Streptococcus pneumoniae D39 4442977 YP_816717.1 CDS nadE NC_008533.1 1278942 1279766 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1278942..1279766) Streptococcus pneumoniae D39 4441558 YP_816718.1 CDS pncB NC_008533.1 1279763 1281223 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1279763..1281223) Streptococcus pneumoniae D39 4441378 YP_816719.1 CDS SPD_1252 NC_008533.1 1281339 1281827 R equivalent gene in S.pneumoniae TIGR4 = SP1422; equivalent gene in S.pneumoniae R6 = spr1278; hypothetical protein complement(1281339..1281827) Streptococcus pneumoniae D39 4442184 YP_816720.1 CDS SPD_1253 NC_008533.1 1281817 1282026 R equivalent gene in S.pneumoniae TIGR4 = SP1423; equivalent gene in S.pneumoniae R6 = spr1279; identified by match to protein family HMM PF01381; transcriptional repressor complement(1281817..1282026) Streptococcus pneumoniae D39 4441964 YP_816721.1 CDS SPD_1254 NC_008533.1 1282411 1283139 R equivalent gene in S.pneumoniae TIGR4 = SP1424; equivalent gene in S.pneumoniae R6 = spr1280; hypothetical protein complement(1282411..1283139) Streptococcus pneumoniae D39 4441379 YP_816722.1 CDS SPD_1255 NC_008533.1 1283155 1283877 R equivalent gene in S.pneumoniae TIGR4 = SP1426; equivalent gene in S.pneumoniae R6 = spr1281; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1283155..1283877) Streptococcus pneumoniae D39 4442590 YP_816723.1 CDS SPD_1256 NC_008533.1 1284382 1285107 R equivalent gene in S.pneumoniae TIGR4 = SP1427; equivalent gene in S.pneumoniae R6 = spr1282; identified by match to protein family HMM PF01136; peptidase, U32 family protein complement(1284382..1285107) Streptococcus pneumoniae D39 4441174 YP_816724.1 CDS SPD_1257 NC_008533.1 1285274 1285441 D equivalent gene in S.pneumoniae R6 = spr1283; hypothetical protein 1285274..1285441 Streptococcus pneumoniae D39 4442177 YP_816725.1 CDS SPD_1258 NC_008533.1 1285696 1286982 R equivalent gene in S.pneumoniae TIGR4 = SP1429; equivalent gene in S.pneumoniae R6 = spr1284; identified by match to protein family HMM PF01136; peptidase, U32 family protein complement(1285696..1286982) Streptococcus pneumoniae D39 4442312 YP_816726.1 CDS SPD_1260 NC_008533.1 1288160 1289338 D Possibly an isoschizomer of XbaI. equivalent gene in S.pneumoniae TIGR4 = SP1431; equivalent gene in S.pneumoniae R6 spr1287; identified by match to protein family HMM PF01555; type II DNA modification methyltransferase 1288160..1289338 Streptococcus pneumoniae D39 4442000 YP_816727.1 CDS SPD_1261 NC_008533.1 1289597 1289743 D equivalent gene in S.pneumoniae TIGR4 = SP1432; hypothetical protein 1289597..1289743 Streptococcus pneumoniae D39 4441417 YP_816728.1 CDS SPD_1262 NC_008533.1 1289865 1290857 R equivalent gene in S.pneumoniae TIGR4 = SP1433; equivalent gene in S.pneumoniae R6 = spr1288; identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(1289865..1290857) Streptococcus pneumoniae D39 4442662 YP_816729.1 CDS SPD_1263 NC_008533.1 1291017 1292771 D equivalent gene in S.pneumoniae TIGR4 = SP1434; equivalent gene in S.pneumoniae R6 = spr1289; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein/permease 1291017..1292771 Streptococcus pneumoniae D39 4442975 YP_816730.1 CDS SPD_1264 NC_008533.1 1292755 1294476 D equivalent gene in S.pneumoniae TIGR4 = SP1435; equivalent gene in S.pneumoniae R6 = spr1290; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1292755..1294476 Streptococcus pneumoniae D39 4442434 YP_816731.1 CDS SPD_1265 NC_008533.1 1294487 1295071 D equivalent gene in S.pneumoniae TIGR4 = SP1436; equivalent gene in S.pneumoniae R6 = spr1291; identified by match to protein family HMM TIGR02185; hypothetical protein 1294487..1295071 Streptococcus pneumoniae D39 4441942 YP_816732.1 CDS SPD_1266 NC_008533.1 1295071 1295766 D equivalent gene in S.pneumoniae TIGR4 = SP1437; equivalent gene in S.pneumoniae R6 = spr1292; identified by match to protein family HMM PF02361; hypothetical protein 1295071..1295766 Streptococcus pneumoniae D39 4442219 YP_816733.1 CDS SPD_1267 NC_008533.1 1295754 1297118 D equivalent gene in S.pneumoniae TIGR4 = SP1438; equivalent gene in S.pneumoniae R6 = spr1293; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1295754..1297118 Streptococcus pneumoniae D39 4442105 YP_816734.1 CDS SPD_1268 NC_008533.1 1297906 1298367 R equivalent gene in S.pneumoniae R6 = spr1294; hypothetical protein complement(1297906..1298367) Streptococcus pneumoniae D39 4442543 YP_816735.1 CDS SPD_1269 NC_008533.1 1298440 1298652 R equivalent gene in S.pneumoniae R6 = spr1295; hypothetical protein complement(1298440..1298652) Streptococcus pneumoniae D39 4442326 YP_816736.1 CDS SPD_1270 NC_008533.1 1298661 1298966 R equivalent gene in S.pneumoniae R6 = spr1296; hypothetical protein complement(1298661..1298966) Streptococcus pneumoniae D39 4441566 YP_816737.1 CDS SPD_1271 NC_008533.1 1298953 1299147 R equivalent gene in S.pneumoniae R6 = spr1297; hypothetical protein complement(1298953..1299147) Streptococcus pneumoniae D39 4442046 YP_816738.1 CDS SPD_1272 NC_008533.1 1299317 1299667 R equivalent gene in S.pneumoniae TIGR4 = SP1442; equivalent gene in S.pneumoniae R6 = spr1298; identified by match to protein family HMM PF05717; IS66 family Orf2 complement(1299317..1299667) Streptococcus pneumoniae D39 4442535 YP_816739.1 CDS SPD_1273 NC_008533.1 1299648 1299887 R equivalent gene in S.pneumoniae TIGR4 = SP1443; equivalent gene in S.pneumoniae R6 = spr1299; IS66 family Orf1 complement(1299648..1299887) Streptococcus pneumoniae D39 4441841 YP_816740.1 CDS guaA NC_008533.1 1300137 1301699 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(1300137..1301699) Streptococcus pneumoniae D39 4442944 YP_816741.1 CDS SPD_1275 NC_008533.1 1301841 1302539 D equivalent gene in S.pneumoniae TIGR4 = SP1446; equivalent gene in S.pneumoniae R6 = spr1301; identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator protein 1301841..1302539 Streptococcus pneumoniae D39 4442638 YP_816742.1 CDS SPD_1276 NC_008533.1 1302582 1303478 R equivalent gene in S.pneumoniae TIGR4 = SP1447; equivalent gene in S.pneumoniae R6 = spr1302; identified by match to protein family HMM PF00892; hypothetical protein complement(1302582..1303478) Streptococcus pneumoniae D39 4442953 YP_816743.1 CDS SPD_1277 NC_008533.1 1303487 1304425 R equivalent gene in S.pneumoniae TIGR4 = SP1448; equivalent gene in S.pneumoniae R6 = spr1303; identified by match to protein family HMM PF00144; hypothetical protein complement(1303487..1304425) Streptococcus pneumoniae D39 4441265 YP_816744.1 CDS cppA NC_008533.1 1304422 1305147 R equivalent gene in S.pneumoniae TIGR4 = SP1449; equivalent gene in S.pneumoniae R6 = spr1304; C3-degrading proteinase complement(1304422..1305147) Streptococcus pneumoniae D39 4442415 YP_816745.1 CDS SPD_1279 NC_008533.1 1305231 1305866 R equivalent gene in S.pneumoniae TIGR4 = SP1450; equivalent gene in S.pneumoniae R6 = spr1305; identified by match to protein family HMM PF00657; GDSL-like lipase/acylhydrolase complement(1305231..1305866) Streptococcus pneumoniae D39 4442667 YP_816746.1 CDS SPD_1280 NC_008533.1 1305868 1306695 R equivalent gene in S.pneumoniae TIGR4 = SP1451; equivalent gene in S.pneumoniae R6 = spr1306; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1305868..1306695) Streptococcus pneumoniae D39 4441369 YP_816747.1 CDS SPD_1281 NC_008533.1 1306717 1307052 R equivalent gene in S.pneumoniae TIGR4 = SP1452; equivalent gene in S.pneumoniae R6 = spr1307; hypothetical protein complement(1306717..1307052) Streptococcus pneumoniae D39 4441209 YP_816748.1 CDS SPD_1282 NC_008533.1 1307053 1307565 R equivalent gene in S.pneumoniae TIGR4 = SP1453; equivalent gene in S.pneumoniae R6 = spr1308; hypothetical protein complement(1307053..1307565) Streptococcus pneumoniae D39 4442791 YP_816749.1 CDS SPD_1283 NC_008533.1 1307659 1307781 R equivalent gene in S.pneumoniae TIGR4 = SP1454; hypothetical protein complement(1307659..1307781) Streptococcus pneumoniae D39 4443027 YP_816750.1 CDS SPD_1284 NC_008533.1 1307857 1307970 D equivalent gene in S.pneumoniae R6 = spr1309; identified by similarity to GB:AAL001131; hypothetical protein 1307857..1307970 Streptococcus pneumoniae D39 4442992 YP_816751.1 CDS def NC_008533.1 1308294 1308905 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1308294..1308905 Streptococcus pneumoniae D39 4441635 YP_816752.1 CDS SPD_1286 NC_008533.1 1308950 1309678 D equivalent gene in S.pneumoniae TIGR4 = SP1457; equivalent gene in S.pneumoniae R6 = spr1311; identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; TrmH family RNA methyltransferase group 3 1308950..1309678 Streptococcus pneumoniae D39 4442172 YP_816753.1 CDS trxB NC_008533.1 1309717 1310628 R equivalent gene in S.pneumoniae TIGR4 = SP1458; equivalent gene in S.pneumoniae R6 = spr1312; identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; thioredoxin-disulfide reductase complement(1309717..1310628) Streptococcus pneumoniae D39 4442060 YP_816754.1 CDS SPD_1288 NC_008533.1 1310694 1310918 R equivalent gene in S.pneumoniae TIGR4 = SP1459; equivalent gene in S.pneumoniae R6 = spr1313; hypothetical protein complement(1310694..1310918) Streptococcus pneumoniae D39 4442220 YP_816755.1 CDS SPD_1289 NC_008533.1 1310996 1311739 R equivalent gene in S.pneumoniae TIGR4 = SP1460; equivalent gene in S.pneumoniae R6 = spr1314; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein complement(1310996..1311739) Streptococcus pneumoniae D39 4442335 YP_816756.1 CDS SPD_1290 NC_008533.1 1311739 1312539 R equivalent gene in S.pneumoniae TIGR4 = SP1461; equivalent gene in S.pneumoniae R6 = spr1315; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(1311739..1312539) Streptococcus pneumoniae D39 4441349 YP_816757.1 CDS SPD_1291 NC_008533.1 1312697 1313053 R equivalent gene in S.pneumoniae TIGR4 = SP1462; equivalent gene in S.pneumoniae R6 = spr1316; identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; hypothetical protein complement(1312697..1313053) Streptococcus pneumoniae D39 4441206 YP_816758.1 CDS ogt NC_008533.1 1313047 1313577 R equivalent gene in S.pneumoniae TIGR4 = SP1463; equivalent gene in S.pneumoniae R6 = spr1317; identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; methylated-DNA--protein-cysteine S-methyltransferase complement(1313047..1313577) Streptococcus pneumoniae D39 4442336 YP_816759.1 CDS SPD_1293 NC_008533.1 1313577 1314071 R equivalent gene in S.pneumoniae TIGR4 = SP1464; equivalent gene in S.pneumoniae R6 = spr1318; identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1313577..1314071) Streptococcus pneumoniae D39 4441087 YP_816760.1 CDS SPD_1294 NC_008533.1 1314206 1314652 D equivalent gene in S.pneumoniae TIGR4 = SP1465; equivalent gene in S.pneumoniae R6 = spr1319; hypothetical protein 1314206..1314652 Streptococcus pneumoniae D39 4441654 YP_816761.1 CDS SPD_1295 NC_008533.1 1314649 1315296 D equivalent gene in S.pneumoniae TIGR4 = SP1466; equivalent gene in S.pneumoniae R6 = spr1320; identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin 1314649..1315296 Streptococcus pneumoniae D39 4442419 YP_816762.1 CDS SPD_1296 NC_008533.1 1315317 1315898 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(1315317..1315898) Streptococcus pneumoniae D39 4442077 YP_816763.1 CDS SPD_1297 NC_008533.1 1315899 1316774 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(1315899..1316774) Streptococcus pneumoniae D39 4442407 YP_816764.1 CDS nox NC_008533.1 1316926 1318305 R equivalent gene in S.pneumoniae TIGR4 = SP1469; equivalent gene in S.pneumoniae R6 = spr1323; identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; NADH oxidase complement(1316926..1318305) Streptococcus pneumoniae D39 4442449 YP_816765.1 CDS SPD_1299 NC_008533.1 1318447 1318602 D hypothetical protein 1318447..1318602 Streptococcus pneumoniae D39 4442471 YP_816766.1 CDS SPD_1300 NC_008533.1 1318599 1319522 D equivalent gene in S.pneumoniae TIGR4 = SP1470; equivalent gene in S.pneumoniae R6 = spr1324; identified by match to protein family HMM PF02424; thiamine biosynthesis protein ApbE 1318599..1319522 Streptococcus pneumoniae D39 4442979 YP_816767.1 CDS SPD_1301 NC_008533.1 1319582 1320187 D equivalent gene in S.pneumoniae TIGR4 = SP1471; equivalent gene in S.pneumoniae R6 = spr1325; identified by match to protein family HMM PF03358; NADPH-dependent FMN reductase 1319582..1320187 Streptococcus pneumoniae D39 4441639 YP_816768.1 CDS SPD_1302 NC_008533.1 1320205 1321449 D equivalent gene in S.pneumoniae TIGR4 = SP1472; equivalent gene in S.pneumoniae R6 = spr1326; identified by match to protein family HMM PF03358; oxidoreductase 1320205..1321449 Streptococcus pneumoniae D39 4441886 YP_816769.1 CDS SPD_1303 NC_008533.1 1321566 1321823 R equivalent gene in S.pneumoniae TIGR4 = SP1473; equivalent gene in S.pneumoniae R6 = spr1327; identified by match to protein family HMM PF05979; hypothetical protein complement(1321566..1321823) Streptococcus pneumoniae D39 4441880 YP_816770.1 CDS glyS NC_008533.1 1321865 1323901 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1321865..1323901) Streptococcus pneumoniae D39 4441512 YP_816771.1 CDS glyQ NC_008533.1 1324161 1325078 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1324161..1325078) Streptococcus pneumoniae D39 4441426 YP_816772.1 CDS SPD_1306 NC_008533.1 1325272 1325661 R equivalent gene in S.pneumoniae TIGR4 = SP1476; equivalent gene in S.pneumoniae R6 = spr1330; hypothetical protein complement(1325272..1325661) Streptococcus pneumoniae D39 4442688 YP_816773.1 CDS SPD_1307 NC_008533.1 1325643 1326032 R equivalent gene in S.pneumoniae TIGR4 = SP1477; equivalent gene in S.pneumoniae R6 = spr1331; hypothetical protein complement(1325643..1326032) Streptococcus pneumoniae D39 4441493 YP_816774.1 CDS SPD_1308 NC_008533.1 1326305 1327147 R equivalent gene in S.pneumoniae TIGR4 = SP1478; equivalent gene in S.pneumoniae R6 = spr1332; identified by match to protein family HMM PF00248; oxidoreductase, aldo/keto reductase family protein complement(1326305..1327147) Streptococcus pneumoniae D39 4442795 YP_816775.1 CDS pgdA NC_008533.1 1327261 1328703 R equivalent gene in S.pneumoniae TIGR4 = SP1479; equivalent gene in S.pneumoniae R6 = spr1333; identified by match to protein family HMM PF01522; peptidoglycan GlcNAc deacetylase complement(1327261..1328703) Streptococcus pneumoniae D39 4441553 YP_816776.1 CDS SPD_1310 NC_008533.1 1328887 1329132 R equivalent gene in S.pneumoniae TIGR4 = SP1480; equivalent gene in S.pneumoniae R6 = spr1334; hypothetical protein complement(1328887..1329132) Streptococcus pneumoniae D39 4441911 YP_816777.1 CDS SPD_1311 NC_008533.1 1329479 1330456 D equivalent gene in S.pneumoniae TIGR4 = SP1482; equivalent gene in S.pneumoniae R6 = spr1335; identified by match to protein family HMM PF01118; match to protein family HMM PF01408; oxidoreductase, Gfo/Idh/MocA family protein 1329479..1330456 Streptococcus pneumoniae D39 4442805 YP_816778.1 CDS SPD_1312 NC_008533.1 1330453 1331535 D equivalent gene in S.pneumoniae TIGR4 = SP1483; equivalent gene in S.pneumoniae R6 = spr1336; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 1330453..1331535 Streptococcus pneumoniae D39 4442188 YP_816779.1 CDS SPD_1316 NC_008533.1 1333510 1333848 R equivalent gene in S.pneumoniae TIGR4 = SP1487; equivalent gene in S.pneumoniae R6 = spr1342; hypothetical protein complement(1333510..1333848) Streptococcus pneumoniae D39 4441454 YP_816780.1 CDS SPD_1317 NC_008533.1 1333971 1334111 R equivalent gene in S.pneumoniae TIGR4 = SP1488; hypothetical protein complement(1333971..1334111) Streptococcus pneumoniae D39 4442237 YP_816781.1 CDS tuf NC_008533.1 1334495 1335691 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1334495..1335691) Streptococcus pneumoniae D39 4441156 YP_816782.1 CDS SPD_1319 NC_008533.1 1336034 1336156 R hypothetical protein complement(1336034..1336156) Streptococcus pneumoniae D39 4441931 YP_816783.1 CDS SPD_1320 NC_008533.1 1336613 1337482 R equivalent gene in S.pneumoniae TIGR4 = SP1491; equivalent gene in S.pneumoniae R6 = spr1344; identified by match to protein family HMM PF00230; glycerol uptake facilitator protein complement(1336613..1337482) Streptococcus pneumoniae D39 4442738 YP_816784.1 CDS SPD_1321 NC_008533.1 1337706 1338314 R equivalent gene in S.pneumoniae TIGR4 = SP1492; equivalent gene in S.pneumoniae R6 = spr1345; identified by match to protein family HMM PF00746; match to protein family HMM PF06458; match to protein family HMM TIGR01167; cell wall surface anchor family protein complement(1337706..1338314) Streptococcus pneumoniae D39 4442956 YP_816785.1 CDS SPD_1322 NC_008533.1 1338272 1339378 R equivalent gene in S.pneumoniae TIGR4 = SP1493; equivalent gene in S.pneumoniae R6 = spr1346; hypothetical protein complement(1338272..1339378) Streptococcus pneumoniae D39 4441613 YP_816786.1 CDS SPD_1323 NC_008533.1 1339489 1339743 R equivalent gene in S.pneumoniae TIGR4 = SP1494; equivalent gene in S.pneumoniae R6 = spr1347; hypothetical protein complement(1339489..1339743) Streptococcus pneumoniae D39 4442310 YP_816787.1 CDS SPD_1324 NC_008533.1 1340101 1340400 R equivalent gene in S.pneumoniae TIGR4 = SP1496; equivalent gene in S.pneumoniae R6 = spr1349; IS630-Spn1, transposase Orf2 complement(1340101..1340400) Streptococcus pneumoniae D39 4441246 YP_816788.1 CDS pgm NC_008533.1 1341179 1342897 D equivalent gene in S.pneumoniae TIGR4 = SP1498; equivalent gene in S.pneumoniae R6 = spr1351; identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphoglucomutase/phosphomannomutase family protein 1341179..1342897 Streptococcus pneumoniae D39 4442743 YP_816789.1 CDS bta NC_008533.1 1343008 1343355 D equivalent gene in S.pneumoniae TIGR4 = SP1499; equivalent gene in S.pneumoniae R6 = spr1352; identified by match to protein family HMM TIGR01295; bacterocin transport accessory protein 1343008..1343355 Streptococcus pneumoniae D39 4443061 YP_816790.1 CDS aatB NC_008533.1 1343634 1344470 R equivalent gene in S.pneumoniae TIGR4 = SP1500; equivalent gene in S.pneumoniae R6 = spr1353; identified by match to protein family HMM PF00497; amino acid ABC transporter amino acid-binding protein complement(1343634..1344470) Streptococcus pneumoniae D39 4442897 YP_816791.1 CDS SPD_1329 NC_008533.1 1344483 1345112 R equivalent gene in S.pneumoniae TIGR4 = SP1501; equivalent gene in S.pneumoniae R6 = spr1354; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein complement(1344483..1345112) Streptococcus pneumoniae D39 4442835 YP_816792.1 CDS SPD_1330 NC_008533.1 1345122 1345763 R equivalent gene in S.pneumoniae TIGR4 = SP1502; equivalent gene in S.pneumoniae R6 = spr1355; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(1345122..1345763) Streptococcus pneumoniae D39 4443080 YP_816793.1 CDS SPD_1331 NC_008533.1 1345909 1347138 R equivalent gene in S.pneumoniae TIGR4 = SP1504; equivalent gene in S.pneumoniae R6 = spr1356; identified by match to protein family HMM PF00515; match to protein family HMM PF07719; hypothetical protein complement(1345909..1347138) Streptococcus pneumoniae D39 4441351 YP_816794.1 CDS SPD_1332 NC_008533.1 1347128 1348294 R equivalent gene in S.pneumoniae TIGR4 = SP1505; equivalent gene in S.pneumoniae R6 = spr1357; identified by match to protein family HMM PF01594; hypothetical protein complement(1347128..1348294) Streptococcus pneumoniae D39 4441959 YP_816795.1 CDS SPD_1333 NC_008533.1 1348438 1349451 D equivalent gene in S.pneumoniae TIGR4 = SP1506; equivalent gene in S.pneumoniae R6 = spr1358; hypothetical protein 1348438..1349451 Streptococcus pneumoniae D39 4441280 YP_816796.1 CDS atpC NC_008533.1 1349496 1349915 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(1349496..1349915) Streptococcus pneumoniae D39 4441604 YP_816797.1 CDS atpD NC_008533.1 1349926 1351332 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(1349926..1351332) Streptococcus pneumoniae D39 4441048 YP_816798.1 CDS atpG NC_008533.1 1351418 1352296 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(1351418..1352296) Streptococcus pneumoniae D39 4442785 YP_816799.1 CDS atpA NC_008533.1 1352312 1353817 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(1352312..1353817) Streptococcus pneumoniae D39 4441807 YP_816800.1 CDS atpH NC_008533.1 1353832 1354368 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(1353832..1354368) Streptococcus pneumoniae D39 4442505 YP_816801.1 CDS atpF NC_008533.1 1354368 1354862 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(1354368..1354862) Streptococcus pneumoniae D39 4442991 YP_816802.1 CDS atpB NC_008533.1 1354876 1355592 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(1354876..1355592) Streptococcus pneumoniae D39 4443045 YP_816803.1 CDS atpE NC_008533.1 1355627 1355827 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(1355627..1355827) Streptococcus pneumoniae D39 4441163 YP_816804.1 CDS SPD_1342 NC_008533.1 1355902 1356909 R equivalent gene in S.pneumoniae TIGR4 = SP0915; equivalent gene in S.pneumoniae R6 = spr1367; identified by match to protein family HMM PF00665; IS1239, transposase complement(1355902..1356909) Streptococcus pneumoniae D39 4442298 YP_816805.1 CDS SPD_1343 NC_008533.1 1357354 1357782 R equivalent gene in S.pneumoniae TIGR4 = SP1516; equivalent gene in S.pneumoniae R6 = spr1368; identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1357354..1357782) Streptococcus pneumoniae D39 4442665 YP_816806.1 CDS SPD_1344 NC_008533.1 1357870 1358277 R hypothetical protein complement(1357870..1358277) Streptococcus pneumoniae D39 4442058 YP_816807.1 CDS greA NC_008533.1 1358305 1358787 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1358305..1358787) Streptococcus pneumoniae D39 4443020 YP_816808.1 CDS SPD_1346 NC_008533.1 1358858 1360513 R YceG family protein; equivalent gene in S.pneumoniae TIGR4 = SP1518; equivalent gene in S.pneumoniae R6 = spr1370; identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; COG1559; hypothetical protein complement(1358858..1360513) Streptococcus pneumoniae D39 4441241 YP_816809.1 CDS SPD_1347 NC_008533.1 1360594 1361088 R equivalent gene in S.pneumoniae TIGR4 = SP1519; equivalent gene in S.pneumoniae R6 = spr1371; identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1360594..1361088) Streptococcus pneumoniae D39 4442322 YP_816810.1 CDS SPD_1348 NC_008533.1 1361085 1361549 R equivalent gene in S.pneumoniae TIGR4 = SP1520; equivalent gene in S.pneumoniae R6 = spr1372; identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1361085..1361549) Streptococcus pneumoniae D39 4441777 YP_816811.1 CDS murC NC_008533.1 1361559 1362893 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1361559..1362893) Streptococcus pneumoniae D39 4441620 YP_816812.1 CDS SPD_1350 NC_008533.1 1362904 1363521 R equivalent gene in S.pneumoniae TIGR4 = SP1522; equivalent gene in S.pneumoniae R6 = spr1374; hypothetical protein complement(1362904..1363521) Streptococcus pneumoniae D39 4441574 YP_816813.1 CDS SPD_1351 NC_008533.1 1363569 1366667 R equivalent gene in S.pneumoniae TIGR4 = SP1523; equivalent gene in S.pneumoniae R6 = spr1375; identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434; Snf2 family protein complement(1363569..1366667) Streptococcus pneumoniae D39 4442120 YP_816814.1 CDS SPD_1352 NC_008533.1 1366760 1367926 R equivalent gene in S.pneumoniae TIGR4 = SP1524; equivalent gene in S.pneumoniae R6 = spr1376; identified by match to protein family HMM PF00155; class II aminotransferase complement(1366760..1367926) Streptococcus pneumoniae D39 4441900 YP_816815.1 CDS SPD_1353 NC_008533.1 1367934 1369028 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(1367934..1369028) Streptococcus pneumoniae D39 4441064 YP_816816.1 CDS SPD_1354 NC_008533.1 1369186 1369338 R This may be a degenerate gene resulting from mutation in the ATP-binding protein located just upstream. equivalent gene in S.pneumoniae R6 = spr1378; hypothetical protein complement(1369186..1369338) Streptococcus pneumoniae D39 4442467 YP_816817.1 CDS SPD_1355 NC_008533.1 1369457 1369909 R This may be a degenerate gene resulting from mutations in an ATP-binding protein liberating the downstream gene. equivalent gene in S.pneumoniae R6 = spr1379; hypothetical protein complement(1369457..1369909) Streptococcus pneumoniae D39 4442626 YP_816818.1 CDS aliB NC_008533.1 1371041 1372999 R equivalent gene in S.pneumoniae TIGR4 = SP1527; equivalent gene in S.pneumoniae R6 = spr1382; identified by match to protein family HMM PF00496; oligopeptide ABC transporter oligopeptide-binding protein AliB complement(1371041..1372999) Streptococcus pneumoniae D39 4441626 YP_816819.1 CDS SPD_1358 NC_008533.1 1373202 1374824 R equivalent gene in S.pneumoniae TIGR4 = SP1529; equivalent gene in S.pneumoniae R6 = spr1383; identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein complement(1373202..1374824) Streptococcus pneumoniae D39 4441882 YP_816820.1 CDS murE NC_008533.1 1374930 1376375 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1374930..1376375 Streptococcus pneumoniae D39 4442610 YP_816821.1 CDS SPD_1360 NC_008533.1 1376421 1376615 R equivalent gene in S.pneumoniae TIGR4 = SP1531; equivalent gene in S.pneumoniae R6 = spr1385; identified by match to protein family HMM PF05532; hypothetical protein complement(1376421..1376615) Streptococcus pneumoniae D39 4442984 YP_816822.1 CDS SPD_1362 NC_008533.1 1377348 1377860 R equivalent gene in S.pneumoniae TIGR4 = SP1533; equivalent gene in S.pneumoniae R6 = spr1388; hypothetical protein complement(1377348..1377860) Streptococcus pneumoniae D39 4442438 YP_816823.1 CDS ppaC NC_008533.1 1377947 1378882 R catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase complement(1377947..1378882) Streptococcus pneumoniae D39 4442182 YP_816824.1 CDS SPD_1364 NC_008533.1 1378953 1379252 R equivalent gene in S.pneumoniae TIGR4 = SP1535; equivalent gene in S.pneumoniae R6 = spr1390; identified by match to protein family HMM PF01541; hypothetical protein complement(1378953..1379252) Streptococcus pneumoniae D39 4441090 YP_816825.1 CDS SPD_1365 NC_008533.1 1379242 1379991 R equivalent gene in S.pneumoniae TIGR4 = SP1536; equivalent gene in S.pneumoniae R6 = spr1391; identified by match to protein family HMM PF05175; hypothetical protein complement(1379242..1379991) Streptococcus pneumoniae D39 4442567 YP_816826.1 CDS SPD_1366 NC_008533.1 1380045 1380404 R equivalent gene in S.pneumoniae TIGR4 = SP1537; equivalent gene in S.pneumoniae R6 = spr1392; identified by match to protein family HMM PF00575; hypothetical protein complement(1380045..1380404) Streptococcus pneumoniae D39 4443014 YP_816827.1 CDS SPD_1367 NC_008533.1 1380406 1381806 R equivalent gene in S.pneumoniae TIGR4 = SP1538; equivalent gene in S.pneumoniae R6 = spr1393; identified by match to protein family HMM PF00160; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein/peptidyl-prolyl cis-trans isomerase complement(1380406..1381806) Streptococcus pneumoniae D39 4442888 YP_816828.1 CDS rpsR NC_008533.1 1382101 1382340 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1382101..1382340) Streptococcus pneumoniae D39 4442300 YP_816829.1 CDS ssb NC_008533.1 1382372 1382842 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1382372..1382842) Streptococcus pneumoniae D39 4442122 YP_816830.1 CDS rpsF NC_008533.1 1382854 1383144 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1382854..1383144) Streptococcus pneumoniae D39 4442290 YP_816831.1 CDS asnC NC_008533.1 1383297 1384640 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1383297..1384640) Streptococcus pneumoniae D39 4441315 YP_816832.1 CDS SPD_1372 NC_008533.1 1384659 1385024 R equivalent gene in S.pneumoniae R6 = spr1398; identified by match to protein family HMM PF00903; glyoxalase family protein complement(1384659..1385024) Streptococcus pneumoniae D39 4442868 YP_816833.1 CDS aspC NC_008533.1 1385017 1386204 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(1385017..1386204) Streptococcus pneumoniae D39 4442818 YP_816834.1 CDS SPD_1374 NC_008533.1 1386201 1386632 R equivalent gene in S.pneumoniae TIGR4 = SP1545; equivalent gene in S.pneumoniae R6 = spr1400; identified by match to protein family HMM PF03413; hypothetical protein complement(1386201..1386632) Streptococcus pneumoniae D39 4441628 YP_816835.1 CDS SPD_1375 NC_008533.1 1387010 1387558 D equivalent gene in S.pneumoniae TIGR4 = SP1546; equivalent gene in S.pneumoniae R6 = spr1402; identified by match to protein family HMM PF02525; match to protein family HMM PF03358; hypothetical protein 1387010..1387558 Streptococcus pneumoniae D39 4441834 YP_816836.1 CDS SPD_1376 NC_008533.1 1387796 1395451 R equivalent gene in S.pneumoniae R6 = spr1403; identified by match to protein family HMM PF01391; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07554; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; G5 domain-containing protein complement(1387796..1395451) Streptococcus pneumoniae D39 4442779 YP_816837.1 CDS SPD_1377 NC_008533.1 1395667 1397151 D equivalent gene in S.pneumoniae R6 = spr1404; identified by match to protein family HMM PF05043; hypothetical protein 1395667..1397151 Streptococcus pneumoniae D39 4442093 YP_816838.1 CDS SPD_1378 NC_008533.1 1397202 1397930 R equivalent gene in S.pneumoniae TIGR4 = SP1547; equivalent gene in S.pneumoniae R6 = spr1405; identified by match to protein family HMM PF03883; hypothetical protein complement(1397202..1397930) Streptococcus pneumoniae D39 4442088 YP_816839.1 CDS SPD_1379 NC_008533.1 1398009 1398173 R equivalent gene in S.pneumoniae R6 = spr1406; hypothetical protein complement(1398009..1398173) Streptococcus pneumoniae D39 4442864 YP_816840.1 CDS SPD_1380 NC_008533.1 1398340 1399935 R equivalent gene in S.pneumoniae TIGR4 = SP1548; equivalent gene in S.pneumoniae R6 = spr1407; hypothetical protein complement(1398340..1399935) Streptococcus pneumoniae D39 4441878 YP_816841.1 CDS def-2 NC_008533.1 1399947 1400357 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1399947..1400357) Streptococcus pneumoniae D39 4441304 YP_816842.1 CDS SPD_1382 NC_008533.1 1400473 1401264 R YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase complement(1400473..1401264) Streptococcus pneumoniae D39 4442807 YP_816843.1 CDS SPD_1383 NC_008533.1 1401277 1403973 R equivalent gene in S.pneumoniae TIGR4 = SP1551; equivalent gene in S.pneumoniae R6 = spr1410; identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; cation-transporting ATPase, E1-E2 family protein complement(1401277..1403973) Streptococcus pneumoniae D39 4442797 YP_816844.1 CDS SPD_1384 NC_008533.1 1404277 1405461 D equivalent gene in S.pneumoniae TIGR4 = SP1552; equivalent gene in S.pneumoniae R6 = spr1411; identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux family protein 1404277..1405461 Streptococcus pneumoniae D39 4441846 YP_816845.1 CDS SPD_1385 NC_008533.1 1405604 1407475 R equivalent gene in S.pneumoniae TIGR4 = SP1553; equivalent gene in S.pneumoniae R6 = spr1412; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1405604..1407475) Streptococcus pneumoniae D39 4442503 YP_816846.1 CDS SPD_1386 NC_008533.1 1407472 1408656 R catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase complement(1407472..1408656) Streptococcus pneumoniae D39 4441984 YP_816847.1 CDS dapB NC_008533.1 1408668 1409435 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(1408668..1409435) Streptococcus pneumoniae D39 4442704 YP_816848.1 CDS SPD_1388 NC_008533.1 1409712 1410560 R equivalent gene in S.pneumoniae TIGR4 = SP1557; equivalent gene in S.pneumoniae R6 = spr1415; identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; DegV family protein complement(1409712..1410560) Streptococcus pneumoniae D39 4442174 YP_816849.1 CDS SPD_1389 NC_008533.1 1410562 1410936 R equivalent gene in S.pneumoniae TIGR4 = SP1558; equivalent gene in S.pneumoniae R6 = spr1416; identified by match to protein family HMM PF06619; hypothetical protein complement(1410562..1410936) Streptococcus pneumoniae D39 4442481 YP_816850.1 CDS glmM NC_008533.1 1411010 1412362 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1411010..1412362) Streptococcus pneumoniae D39 4441648 YP_816851.1 CDS SPD_1391 NC_008533.1 1412386 1413165 R equivalent gene in S.pneumoniae TIGR4 = SP1560; equivalent gene in S.pneumoniae R6 = spr1418; identified by match to protein family HMM PF07949; hypothetical protein complement(1412386..1413165) Streptococcus pneumoniae D39 4441923 YP_816852.1 CDS SPD_1392 NC_008533.1 1413152 1413967 R equivalent gene in S.pneumoniae TIGR4 = SP1561; equivalent gene in S.pneumoniae R6 = spr1419; identified by match to protein family HMM PF02457; match to protein family HMM TIGR00159; hypothetical protein complement(1413152..1413967) Streptococcus pneumoniae D39 4441778 YP_816853.1 CDS SPD_1393 NC_008533.1 1414145 1415113 D equivalent gene in S.pneumoniae TIGR4 = SP1563; equivalent gene in S.pneumoniae R6 = spr1421; identified by match to protein family HMM PF00070; match to protein family HMM PF03486; match to protein family HMM PF07992; pyridine nucleotide-disulfide oxidoreductase family protein 1414145..1415113 Streptococcus pneumoniae D39 4442814 YP_816854.1 CDS SPD_1394 NC_008533.1 1415147 1416058 R equivalent gene in S.pneumoniae TIGR4 = SP1564; equivalent gene in S.pneumoniae R6 = spr1422; identified by match to protein family HMM PF02650; match to protein family HMM TIGR00647; COG1481; hypothetical protein complement(1415147..1416058) Streptococcus pneumoniae D39 4442995 YP_816855.1 CDS SPD_1395 NC_008533.1 1416055 1417032 R equivalent gene in S.pneumoniae TIGR4 = SP1565; equivalent gene in S.pneumoniae R6 = spr1423; identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; hypothetical protein complement(1416055..1417032) Streptococcus pneumoniae D39 4442575 YP_816856.1 CDS SPD_1396 NC_008533.1 1417029 1417919 R equivalent gene in S.pneumoniae TIGR4 = SP1566; equivalent gene in S.pneumoniae R6 = spr1424; identified by match to protein family HMM PF03668; hypothetical protein complement(1417029..1417919) Streptococcus pneumoniae D39 4441088 YP_816857.1 CDS SPD_1397 NC_008533.1 1417971 1418351 R equivalent gene in S.pneumoniae TIGR4 = SP1567; equivalent gene in S.pneumoniae R6 = spr1425; identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; endoribonuclease L-PSP complement(1417971..1418351) Streptococcus pneumoniae D39 4443023 YP_816858.1 CDS engB NC_008533.1 1418362 1418949 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1418362..1418949) Streptococcus pneumoniae D39 4442463 YP_816859.1 CDS clpX NC_008533.1 1418958 1420190 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1418958..1420190) Streptococcus pneumoniae D39 4442365 YP_816860.1 CDS SPD_1400 NC_008533.1 1420222 1420392 R equivalent gene in S.pneumoniae TIGR4 = SP1570; equivalent gene in S.pneumoniae R6 = spr1428; hypothetical protein complement(1420222..1420392) Streptococcus pneumoniae D39 4441704 YP_816861.1 CDS folA NC_008533.1 1420392 1420898 R equivalent gene in S.pneumoniae TIGR4 = SP1571; equivalent gene in S.pneumoniae R6 = spr1429; identified by match to protein family HMM PF00186; dihydrofolate reductase complement(1420392..1420898) Streptococcus pneumoniae D39 4442919 YP_816862.1 CDS SPD_1402 NC_008533.1 1421028 1421546 R equivalent gene in S.pneumoniae TIGR4 = SP1572; equivalent gene in S.pneumoniae R6 = spr1430; identified by match to protein family HMM PF00210; non-heme iron-containing ferritin complement(1421028..1421546) Streptococcus pneumoniae D39 4442862 YP_816863.1 CDS lytC NC_008533.1 1422042 1423514 R equivalent gene in S.pneumoniae TIGR4 = SP1573; equivalent gene in S.pneumoniae R6 = spr1431; identified by match to protein family HMM PF01183; match to protein family HMM PF01473; 1,4-beta-N-acetylmuramidase complement(1422042..1423514) Streptococcus pneumoniae D39 4441545 YP_816864.1 CDS tpiA NC_008533.1 1423585 1424343 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1423585..1424343) Streptococcus pneumoniae D39 4442193 YP_816865.1 CDS SPD_1405 NC_008533.1 1424441 1425118 R equivalent gene in S.pneumoniae TIGR4 = SP1575; equivalent gene in S.pneumoniae R6 = spr1433; identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; hypothetical protein complement(1424441..1425118) Streptococcus pneumoniae D39 4441691 YP_816866.1 CDS metA NC_008533.1 1425127 1426071 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(1425127..1426071) Streptococcus pneumoniae D39 4442126 YP_816867.1 CDS apt NC_008533.1 1426253 1426783 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1426253..1426783) Streptococcus pneumoniae D39 4441767 YP_816868.1 CDS SPD_1408 NC_008533.1 1426853 1427611 R equivalent gene in S.pneumoniae TIGR4 = SP1578; equivalent gene in S.pneumoniae R6 = spr1436; hypothetical protein complement(1426853..1427611) Streptococcus pneumoniae D39 4441904 YP_816869.1 CDS SPD_1409 NC_008533.1 1428112 1429242 R equivalent gene in S.pneumoniae TIGR4 = SP1580; equivalent gene in S.pneumoniae R6 = spr1437; identified by match to protein family HMM PF00005; match to protein family HMM PF03459; sugar ABC transporter ATP-binding protein complement(1428112..1429242) Streptococcus pneumoniae D39 4442987 YP_816870.1 CDS SPD_1411 NC_008533.1 1429692 1430267 R equivalent gene in S.pneumoniae TIGR4 = SP1583; equivalent gene in S.pneumoniae R6 = spr1438; identified by match to protein family HMM PF00857; isochorismatase family protein complement(1429692..1430267) Streptococcus pneumoniae D39 4441590 YP_816871.1 CDS codY NC_008533.1 1430267 1431055 R CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY complement(1430267..1431055) Streptococcus pneumoniae D39 4442404 YP_816872.1 CDS SPD_1413 NC_008533.1 1431319 1432893 R equivalent gene in S.pneumoniae TIGR4 = SP1586; equivalent gene in S.pneumoniae R6 = spr1440; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase complement(1431319..1432893) Streptococcus pneumoniae D39 4441573 YP_816873.1 CDS SPD_1414 NC_008533.1 1433092 1434318 R equivalent gene in S.pneumoniae TIGR4 = SP1587; equivalent gene in S.pneumoniae R6 = spr1441; identified by match to protein family HMM PF07690; oxalate/formate antiporter complement(1433092..1434318) Streptococcus pneumoniae D39 4442939 YP_816874.1 CDS SPD_1415 NC_008533.1 1434508 1435824 D Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1434508..1435824 Streptococcus pneumoniae D39 4442490 YP_816875.1 CDS SPD_1416 NC_008533.1 1435923 1437266 D equivalent gene in S.pneumoniae TIGR4 = SP1589; equivalent gene in S.pneumoniae R6 = spr1443; hypothetical protein 1435923..1437266 Streptococcus pneumoniae D39 4441046 YP_816876.1 CDS SPD_1417 NC_008533.1 1437266 1438048 D equivalent gene in S.pneumoniae TIGR4 = SP1590; equivalent gene in S.pneumoniae R6 = spr1444; identified by match to protein family HMM PF07685; hypothetical protein 1437266..1438048 Streptococcus pneumoniae D39 4441345 YP_816877.1 CDS pepQ NC_008533.1 1438174 1439256 D equivalent gene in S.pneumoniae TIGR4 = SP1591; equivalent gene in S.pneumoniae R6 = spr1445; identified by match to protein family HMM PF00557; proline dipeptidase PepQ 1438174..1439256 Streptococcus pneumoniae D39 4442210 YP_816878.1 CDS SPD_1419 NC_008533.1 1439249 1439452 D equivalent gene in S.pneumoniae TIGR4 = SP1592; hypothetical protein 1439249..1439452 Streptococcus pneumoniae D39 4441829 YP_816879.1 CDS SPD_1422 NC_008533.1 1441071 1441532 R equivalent gene in S.pneumoniae TIGR4 = SP1597; equivalent gene in S.pneumoniae R6 = spr1449; hypothetical protein complement(1441071..1441532) Streptococcus pneumoniae D39 4441666 YP_816880.1 CDS SPD_1423 NC_008533.1 1441510 1442283 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(1441510..1442283) Streptococcus pneumoniae D39 4442161 YP_816881.1 CDS truA NC_008533.1 1442273 1443022 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1442273..1443022) Streptococcus pneumoniae D39 4442238 YP_816882.1 CDS SPD_1425 NC_008533.1 1443335 1444486 R equivalent gene in S.pneumoniae TIGR4 = SP1600; equivalent gene in S.pneumoniae R6 = spr1453; identified by match to protein family HMM PF07690; transporter major facilitator family protein complement(1443335..1444486) Streptococcus pneumoniae D39 4441337 YP_816883.1 CDS SPD_1426 NC_008533.1 1444726 1445355 R equivalent gene in S.pneumoniae TIGR4 = SP1601; equivalent gene in S.pneumoniae R6 = spr1454; hypothetical protein complement(1444726..1445355) Streptococcus pneumoniae D39 4441588 YP_816884.1 CDS phnA NC_008533.1 1445358 1445696 R equivalent gene in S.pneumoniae TIGR4 = SP1602; equivalent gene in S.pneumoniae R6 = spr1455; identified by match to protein family HMM PF03831; match to protein family HMM TIGR00686; PhnA protein complement(1445358..1445696) Streptococcus pneumoniae D39 4441591 YP_816885.1 CDS cmk NC_008533.1 1445827 1446498 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(1445827..1446498) Streptococcus pneumoniae D39 4442698 YP_816886.1 CDS SPD_1429 NC_008533.1 1446507 1446983 R equivalent gene in S.pneumoniae TIGR4 = SP1604; equivalent gene in S.pneumoniae R6 = spr1457; hypothetical protein complement(1446507..1446983) Streptococcus pneumoniae D39 4442269 YP_816887.1 CDS fer NC_008533.1 1447035 1447241 D equivalent gene in S.pneumoniae TIGR4 = SP1605; equivalent gene in S.pneumoniae R6 = spr1458; ferredoxin 1447035..1447241 Streptococcus pneumoniae D39 4442780 YP_816888.1 CDS SPD_1431 NC_008533.1 1447303 1448256 R equivalent gene in S.pneumoniae TIGR4 = SP1606; equivalent gene in S.pneumoniae R6 = spr1459; identified by match to protein family HMM PF00535; glycosyl transferase family protein complement(1447303..1448256) Streptococcus pneumoniae D39 4441300 YP_816889.1 CDS galE-1 NC_008533.1 1448258 1449277 R equivalent gene in S.pneumoniae TIGR4 = SP1607; equivalent gene in S.pneumoniae R6 = spr1460; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase complement(1448258..1449277) Streptococcus pneumoniae D39 4442819 YP_816890.1 CDS SPD_1433 NC_008533.1 1449578 1450681 R equivalent gene in S.pneumoniae TIGR4 = SP1608; equivalent gene in S.pneumoniae R6 = spr1461; identified by match to protein family HMM PF01266; FAD dependent oxidoreductase complement(1449578..1450681) Streptococcus pneumoniae D39 4441765 YP_816891.1 CDS SPD_1434 NC_008533.1 1450698 1451495 R equivalent gene in S.pneumoniae TIGR4 = SP1609; equivalent gene in S.pneumoniae R6 = spr1462; identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; hypothetical protein complement(1450698..1451495) Streptococcus pneumoniae D39 4442345 YP_816892.1 CDS SPD_1435 NC_008533.1 1451482 1452159 R equivalent gene in S.pneumoniae TIGR4 = SP1610; equivalent gene in S.pneumoniae R6 = spr1463; identified by match to protein family HMM PF04816; hypothetical protein complement(1451482..1452159) Streptococcus pneumoniae D39 4442696 YP_816893.1 CDS SPD_1436 NC_008533.1 1452261 1454597 R equivalent gene in S.pneumoniae TIGR4 = SP1623; equivalent gene in S.pneumoniae R6 = spr1464; identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; cation-transporting ATPase, E1-E2 family protein complement(1452261..1454597) Streptococcus pneumoniae D39 4441339 YP_816894.1 CDS SPD_1437 NC_008533.1 1454730 1455479 D equivalent gene in S.pneumoniae TIGR4 = SP1624; equivalent gene in S.pneumoniae R6 = spr1465; identified by match to protein family HMM PF01553; acyltransferase domain-containing protein 1454730..1455479 Streptococcus pneumoniae D39 4442648 YP_816895.1 CDS SPD_1438 NC_008533.1 1455772 1456386 R equivalent gene in S.pneumoniae TIGR4 = SP1625; equivalent gene in S.pneumoniae R6 = spr1466; identified by match to protein family HMM PF03596; match to protein family HMM TIGR00779; cadmium resistance transporter complement(1455772..1456386) Streptococcus pneumoniae D39 4442583 YP_816896.1 CDS rpsO NC_008533.1 1457120 1457389 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1457120..1457389) Streptococcus pneumoniae D39 4441864 YP_816897.1 CDS SPD_1440 NC_008533.1 1457530 1458159 R equivalent gene in S.pneumoniae TIGR4 = SP1627; equivalent gene in S.pneumoniae R6 = spr1468; hypothetical protein complement(1457530..1458159) Streptococcus pneumoniae D39 4442679 YP_816898.1 CDS SPD_1441 NC_008533.1 1458222 1458344 D hypothetical protein 1458222..1458344 Streptococcus pneumoniae D39 4442958 YP_816899.1 CDS SPD_1442 NC_008533.1 1458963 1459169 D equivalent gene in S.pneumoniae TIGR4 = SP1630; equivalent gene in S.pneumoniae R6 = spr1470; hypothetical protein 1458963..1459169 Streptococcus pneumoniae D39 4442998 YP_816900.1 CDS SPD_1443 NC_008533.1 1459176 1459352 D equivalent gene in S.pneumoniae TIGR4 = SP1630; equivalent gene in S.pneumoniae R6 = spr1471; hypothetical protein 1459176..1459352 Streptococcus pneumoniae D39 4441921 YP_816901.1 CDS thrS NC_008533.1 1459410 1461353 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1459410..1461353 Streptococcus pneumoniae D39 4441080 YP_816902.1 CDS SPD_1445 NC_008533.1 1461402 1462376 R equivalent gene in S.pneumoniae TIGR4 = SP1632; equivalent gene in S.pneumoniae R6 = spr1473; identified by match to protein family HMM PF02518; sensor histidine kinase complement(1461402..1462376) Streptococcus pneumoniae D39 4442111 YP_816903.1 CDS SPD_1446 NC_008533.1 1462369 1463046 R equivalent gene in S.pneumoniae TIGR4 = SP1633; equivalent gene in S.pneumoniae R6 = spr1474; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator complement(1462369..1463046) Streptococcus pneumoniae D39 4442218 YP_816904.1 CDS SPD_1447 NC_008533.1 1463202 1464275 D equivalent gene in S.pneumoniae TIGR4 = SP1634; equivalent gene in S.pneumoniae R6 = spr1475; hypothetical protein 1463202..1464275 Streptococcus pneumoniae D39 4442038 YP_816905.1 CDS SPD_1448 NC_008533.1 1464737 1465174 R equivalent gene in S.pneumoniae TIGR4 = SP1636; equivalent gene in S.pneumoniae R6 = spr1477; identified by match to protein family HMM PF02082; Rrf2 family protein complement(1464737..1465174) Streptococcus pneumoniae D39 4441116 YP_816906.1 CDS SPD_1449 NC_008533.1 1465250 1466092 R equivalent gene in S.pneumoniae TIGR4 = SP1637; equivalent gene in S.pneumoniae R6 = spr1479; identified by match to protein family HMM PF00149; hypothetical protein complement(1465250..1466092) Streptococcus pneumoniae D39 4442554 YP_816907.1 CDS SPD_1450 NC_008533.1 1466204 1466854 D equivalent gene in S.pneumoniae TIGR4 = SP1638; equivalent gene in S.pneumoniae R6 = spr1480; identified by match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023; iron-dependent transcriptional regulator 1466204..1466854 Streptococcus pneumoniae D39 4442296 YP_816908.1 CDS SPD_1451 NC_008533.1 1466835 1467005 D equivalent gene in S.pneumoniae R6 = spr1481; hypothetical protein 1466835..1467005 Streptococcus pneumoniae D39 4442382 YP_816909.1 CDS SPD_1452 NC_008533.1 1467156 1467548 D equivalent gene in S.pneumoniae R6 = spr1482; hypothetical protein 1467156..1467548 Streptococcus pneumoniae D39 4441632 YP_816910.1 CDS SPD_1454 NC_008533.1 1467807 1468244 D equivalent gene in S.pneumoniae TIGR4 = SP1641; equivalent gene in S.pneumoniae R6 = spr1483; hypothetical protein 1467807..1468244 Streptococcus pneumoniae D39 4442960 YP_816911.1 CDS SPD_1455 NC_008533.1 1469540 1469653 D equivalent gene in S.pneumoniae TIGR4 = SP1642 This gene has a frameshift relative to the TIGR4 SP1642 gene.; hypothetical protein 1469540..1469653 Streptococcus pneumoniae D39 4442494 YP_816912.1 CDS SPD_1456 NC_008533.1 1469793 1469954 D equivalent gene in S.pneumoniae TIGR4 = SP1643; equivalent gene in S.pneumoniae R6 = spr1485; hypothetical protein 1469793..1469954 Streptococcus pneumoniae D39 4442930 YP_816913.1 CDS dtd NC_008533.1 1469993 1470436 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1469993..1470436) Streptococcus pneumoniae D39 4442713 YP_816914.1 CDS relA NC_008533.1 1470466 1472688 R equivalent gene in S.pneumoniae TIGR4 = SP1645; equivalent gene in S.pneumoniae R6 = spr1487; identified by match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; GTP pyrophosphokinase complement(1470466..1472688) Streptococcus pneumoniae D39 4442334 YP_816915.1 CDS SPD_1459 NC_008533.1 1473683 1474312 D equivalent gene in S.pneumoniae TIGR4 = SP1646; equivalent gene in S.pneumoniae R6 = spr1490; identified by match to protein family HMM PF00753; metallo-beta-lactamase superfamily protein 1473683..1474312 Streptococcus pneumoniae D39 4441568 YP_816916.1 CDS pepO NC_008533.1 1474435 1476327 R equivalent gene in S.pneumoniae TIGR4 = SP1647; equivalent gene in S.pneumoniae R6 = spr1491; identified by match to protein family HMM PF01431; match to protein family HMM PF05649; endopeptidase O complement(1474435..1476327) Streptococcus pneumoniae D39 4441913 YP_816917.1 CDS psaB NC_008533.1 1476618 1477340 D equivalent gene in S.pneumoniae TIGR4 = SP1648; equivalent gene in S.pneumoniae R6 = spr1492; identified by match to protein family HMM PF00005; manganese ABC transporter ATP-binding protein 1476618..1477340 Streptococcus pneumoniae D39 4442774 YP_816918.1 CDS psaC NC_008533.1 1477337 1478185 D equivalent gene in S.pneumoniae TIGR4 = SP1649; equivalent gene in S.pneumoniae R6 = spr1493; identified by match to protein family HMM PF00950; manganese ABC transporter permease 1477337..1478185 Streptococcus pneumoniae D39 4442282 YP_816919.1 CDS SPD_1463 NC_008533.1 1478217 1479146 D equivalent gene in S.pneumoniae TIGR4 = SP1650; equivalent gene in S.pneumoniae R6 = spr1494; identified by match to protein family HMM PF01297; ABC transporter substrate-binding protein 1478217..1479146 Streptococcus pneumoniae D39 4442424 YP_816920.1 CDS tpx NC_008533.1 1479269 1479760 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1479269..1479760 Streptococcus pneumoniae D39 4441865 YP_816921.1 CDS SPD_1465 NC_008533.1 1479856 1482564 R equivalent gene in S.pneumoniae TIGR4 = SP1652; equivalent gene in S.pneumoniae R6 = spr1496; identified by match to protein family HMM PF02687; hypothetical protein complement(1479856..1482564) Streptococcus pneumoniae D39 4442755 YP_816922.1 CDS SPD_1466 NC_008533.1 1482566 1483267 R equivalent gene in S.pneumoniae TIGR4 = SP1653; equivalent gene in S.pneumoniae R6 = spr1497; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1482566..1483267) Streptococcus pneumoniae D39 4442982 YP_816923.1 CDS SPD_1467 NC_008533.1 1483517 1485928 R equivalent gene in S.pneumoniae TIGR4 = SP1654; equivalent gene in S.pneumoniae R6 = spr1498; hypothetical protein complement(1483517..1485928) Streptococcus pneumoniae D39 4442675 YP_816924.1 CDS gpmA NC_008533.1 1485981 1486673 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1485981..1486673) Streptococcus pneumoniae D39 4442440 YP_816925.1 CDS SPD_1469 NC_008533.1 1486724 1486912 R equivalent gene in S.pneumoniae TIGR4 = SP1656; equivalent gene in S.pneumoniae R6 = spr1500; hypothetical protein complement(1486724..1486912) Streptococcus pneumoniae D39 4441322 YP_816926.1 CDS SPD_1470 NC_008533.1 1487288 1487428 R equivalent gene in S.pneumoniae TIGR4 = SP1658; equivalent gene in S.pneumoniae R6 = spr1501; hypothetical protein complement(1487288..1487428) Streptococcus pneumoniae D39 4441505 YP_816927.1 CDS SPD_1471 NC_008533.1 1487432 1487548 R equivalent gene in S.pneumoniae TIGR4 = SP1658; hypothetical protein complement(1487432..1487548) Streptococcus pneumoniae D39 4441801 YP_816928.1 CDS ileS NC_008533.1 1487996 1490788 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1487996..1490788) Streptococcus pneumoniae D39 4441344 YP_816929.1 CDS SPD_1473 NC_008533.1 1491041 1491157 R hypothetical protein complement(1491041..1491157) Streptococcus pneumoniae D39 4442232 YP_816930.1 CDS divIVA NC_008533.1 1491136 1491924 R equivalent gene in S.pneumoniae TIGR4 = SP1661; equivalent gene in S.pneumoniae R6 = spr1505; identified by match to protein family HMM PF05103; cell division protein DivIVA complement(1491136..1491924) Streptococcus pneumoniae D39 4441335 YP_816931.1 CDS ylmH NC_008533.1 1491933 1492718 R equivalent gene in S.pneumoniae TIGR4 = SP1662; equivalent gene in S.pneumoniae R6 = spr1506; identified by match to protein family HMM PF01479; YlmH protein complement(1491933..1492718) Streptococcus pneumoniae D39 4442125 YP_816932.1 CDS ylmG NC_008533.1 1492715 1492978 R equivalent gene in S.pneumoniae TIGR4 = SP1663; equivalent gene in S.pneumoniae R6 = spr1507; identified by match to protein family HMM PF02325; hypothetical protein complement(1492715..1492978) Streptococcus pneumoniae D39 4441364 YP_816933.1 CDS ylmF NC_008533.1 1492978 1493517 R equivalent gene in S.pneumoniae TIGR4 = SP1664; equivalent gene in S.pneumoniae R6 = spr1508; identified by match to protein family HMM PF04472; hypothetical protein complement(1492978..1493517) Streptococcus pneumoniae D39 4442890 YP_816934.1 CDS ylmE NC_008533.1 1493527 1494198 R equivalent gene in S.pneumoniae TIGR4 = SP1665; equivalent gene in S.pneumoniae R6 = spr1509; identified by match to protein family HMM TIGR00044; YlmE protein complement(1493527..1494198) Streptococcus pneumoniae D39 4443032 YP_816935.1 CDS ftsZ NC_008533.1 1494203 1495462 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1494203..1495462) Streptococcus pneumoniae D39 4442611 YP_816936.1 CDS ftsA NC_008533.1 1495479 1496852 R equivalent gene in S.pneumoniae TIGR4 = SP1667; equivalent gene in S.pneumoniae R6 = spr1511; identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174; cell division protein FtsA complement(1495479..1496852) Streptococcus pneumoniae D39 4441979 YP_816937.1 CDS SPD_1481 NC_008533.1 1497071 1497775 R equivalent gene in S.pneumoniae TIGR4 = SP1668; equivalent gene in S.pneumoniae R6 = spr1512; identified by match to protein family HMM TIGR02206; hypothetical protein complement(1497071..1497775) Streptococcus pneumoniae D39 4442557 YP_816938.1 CDS SPD_1482 NC_008533.1 1497866 1498477 R equivalent gene in S.pneumoniae TIGR4 = SP1669; equivalent gene in S.pneumoniae R6 = spr1513; identified by match to protein family HMM PF00293; MutT/nudix family protein complement(1497866..1498477) Streptococcus pneumoniae D39 4441256 YP_816939.1 CDS murF NC_008533.1 1498464 1499837 R equivalent gene in S.pneumoniae TIGR4 = SP1670; equivalent gene in S.pneumoniae R6 = spr1514; identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM TIGR01143; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanine ligase complement(1498464..1499837) Streptococcus pneumoniae D39 4442412 YP_816940.1 CDS ddl NC_008533.1 1499921 1500964 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1499921..1500964) Streptococcus pneumoniae D39 4442150 YP_816941.1 CDS recR NC_008533.1 1501140 1501736 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1501140..1501736) Streptococcus pneumoniae D39 4441569 YP_816942.1 CDS penA NC_008533.1 1501747 1503804 R equivalent gene in S.pneumoniae TIGR4 = SP1673; equivalent gene in S.pneumoniae R6 = spr1517; identified by match to protein family HMM PF00905; match to protein family HMM PF03717; penicillin-binding protein 2B complement(1501747..1503804) Streptococcus pneumoniae D39 4441870 YP_816943.1 CDS SPD_1487 NC_008533.1 1504004 1504855 D equivalent gene in S.pneumoniae TIGR4 = SP1674; equivalent gene in S.pneumoniae R6 = spr1518; identified by match to protein family HMM PF01380; match to protein family HMM PF01418; phosphosugar-binding transcriptional regulator 1504004..1504855 Streptococcus pneumoniae D39 4441520 YP_816944.1 CDS SPD_1488 NC_008533.1 1504871 1505755 R equivalent gene in S.pneumoniae TIGR4 = SP1675; equivalent gene in S.pneumoniae R6 = spr1519; identified by match to protein family HMM PF00480; ROK family protein complement(1504871..1505755) Streptococcus pneumoniae D39 4442644 YP_816945.1 CDS SPD_1489 NC_008533.1 1505773 1506504 R equivalent gene in S.pneumoniae TIGR4 = SP1676; equivalent gene in S.pneumoniae R6 = spr1520; identified by match to protein family HMM PF00701; N-acetylneuraminate lyase complement(1505773..1506504) Streptococcus pneumoniae D39 4441257 YP_816946.1 CDS SPD_1490 NC_008533.1 1506873 1507337 R equivalent gene in S.pneumoniae TIGR4 = SP1677; equivalent gene in S.pneumoniae R6 = spr1522; identified by match to protein family HMM PF04854; hypothetical protein complement(1506873..1507337) Streptococcus pneumoniae D39 4442663 YP_816947.1 CDS SPD_1491 NC_008533.1 1507624 1507968 R equivalent gene in S.pneumoniae R6 = spr1523; hypothetical protein complement(1507624..1507968) Streptococcus pneumoniae D39 4442429 YP_816948.1 CDS SPD_1492 NC_008533.1 1508065 1508517 R equivalent gene in S.pneumoniae TIGR4 = SP1680; equivalent gene in S.pneumoniae R6 = spr1524; identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1508065..1508517) Streptococcus pneumoniae D39 4441178 YP_816949.1 CDS SPD_1493 NC_008533.1 1508790 1509629 R equivalent gene in S.pneumoniae TIGR4 = SP1681; equivalent gene in S.pneumoniae R6 = spr1525; identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1508790..1509629) Streptococcus pneumoniae D39 4441703 YP_816950.1 CDS SPD_1494 NC_008533.1 1509645 1510532 R equivalent gene in S.pneumoniae TIGR4 = SP1682; equivalent gene in S.pneumoniae R6 = spr1526; identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1509645..1510532) Streptococcus pneumoniae D39 4442304 YP_816951.1 CDS SPD_1495 NC_008533.1 1510763 1512091 R equivalent gene in S.pneumoniae TIGR4 = SP1683; equivalent gene in S.pneumoniae R6 = spr1527; identified by match to protein family HMM PF01547; sugar ABC transporter sugar-binding protein complement(1510763..1512091) Streptococcus pneumoniae D39 4442475 YP_816952.1 CDS SPD_1496 NC_008533.1 1512216 1513733 R equivalent gene in S.pneumoniae TIGR4 = SP1684; equivalent gene in S.pneumoniae R6 = spr1528; identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; PTS system transporter subunit IIBC complement(1512216..1513733) Streptococcus pneumoniae D39 4442051 YP_816953.1 CDS nanE-1 NC_008533.1 1513752 1514450 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1513752..1514450) Streptococcus pneumoniae D39 4441385 YP_816954.1 CDS SPD_1498 NC_008533.1 1514630 1515733 R equivalent gene in S.pneumoniae TIGR4 = SP1686; equivalent gene in S.pneumoniae R6 = spr1530; identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; oxidoreductase complement(1514630..1515733) Streptococcus pneumoniae D39 4441633 YP_816955.1 CDS nanB NC_008533.1 1515745 1517838 R neuraminidase B; equivalent gene in S.pneumoniae TIGR4 = SP1687; equivalent gene in S.pneumoniae R6 = spr1531; identified by match to protein family HMM PF02012; match to protein family HMM PF02973; sialidase B complement(1515745..1517838) Streptococcus pneumoniae D39 4442008 YP_816956.1 CDS SPD_1500 NC_008533.1 1517856 1518689 R equivalent gene in S.pneumoniae TIGR4 = SP1688; equivalent gene in S.pneumoniae R6 = spr1532; identified by match to protein family HMM PF00528; ABC transporter permease complement(1517856..1518689) Streptococcus pneumoniae D39 4442820 YP_816957.1 CDS SPD_1501 NC_008533.1 1518689 1519573 R equivalent gene in S.pneumoniae TIGR4 = SP1689; equivalent gene in S.pneumoniae R6 = spr1533; identified by match to protein family HMM PF00528; ABC transporter permease complement(1518689..1519573) Streptococcus pneumoniae D39 4441243 YP_816958.1 CDS SPD_1502 NC_008533.1 1519652 1520989 R equivalent gene in S.pneumoniae TIGR4 = SP1690; equivalent gene in S.pneumoniae R6 = spr1534; identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein complement(1519652..1520989) Streptococcus pneumoniae D39 4442092 YP_816959.1 CDS SPD_1503 NC_008533.1 1521008 1521460 R equivalent gene in S.pneumoniae TIGR4 = SP1691; equivalent gene in S.pneumoniae R6 = spr1535; identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1521008..1521460) Streptococcus pneumoniae D39 4441211 YP_816960.1 CDS nanA NC_008533.1 1522475 1525468 R equivalent gene in S.pneumoniae R6 = spr1536; identified by match to protein family HMM PF02012; match to protein family HMM PF02973; match to protein family HMM TIGR01167; sialidase A complement(1522475..1525468) Streptococcus pneumoniae D39 4442379 YP_816961.1 CDS SPD_1505 NC_008533.1 1525825 1526052 R equivalent gene in S.pneumoniae TIGR4 = SP1694; equivalent gene in S.pneumoniae R6 = spr1537; hypothetical protein complement(1525825..1526052) Streptococcus pneumoniae D39 4442903 YP_816962.1 CDS SPD_1506 NC_008533.1 1526947 1527927 R equivalent gene in S.pneumoniae TIGR4 = SP1695; equivalent gene in S.pneumoniae R6 = spr1538; identified by match to protein family HMM PF05448; acetyl xylan esterase complement(1526947..1527927) Streptococcus pneumoniae D39 4442036 YP_816963.1 CDS recG NC_008533.1 1528243 1530258 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(1528243..1530258) Streptococcus pneumoniae D39 4442537 YP_816964.1 CDS alr NC_008533.1 1530277 1531380 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1530277..1531380) Streptococcus pneumoniae D39 4441665 YP_816965.1 CDS acpS NC_008533.1 1531370 1531732 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1531370..1531732) Streptococcus pneumoniae D39 4441372 YP_816966.1 CDS SPD_1510 NC_008533.1 1531777 1532808 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1531777..1532808) Streptococcus pneumoniae D39 4441138 YP_816967.1 CDS SPD_1511 NC_008533.1 1532810 1533841 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1532810..1533841) Streptococcus pneumoniae D39 4441842 YP_816968.1 CDS secA NC_008533.1 1533922 1536435 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1533922..1536435) Streptococcus pneumoniae D39 4442480 YP_816969.1 CDS SPD_1514 NC_008533.1 1536881 1537531 R equivalent gene in S.pneumoniae TIGR4 = SP1704; equivalent gene in S.pneumoniae R6 = spr1546; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1536881..1537531) Streptococcus pneumoniae D39 4442799 YP_816970.1 CDS SPD_1515 NC_008533.1 1537535 1538110 R equivalent gene in S.pneumoniae TIGR4 = SP1705; equivalent gene in S.pneumoniae R6 = spr1547; hypothetical protein complement(1537535..1538110) Streptococcus pneumoniae D39 4442548 YP_816971.1 CDS SPD_1516 NC_008533.1 1538169 1538960 R equivalent gene in S.pneumoniae TIGR4 = SP1706; equivalent gene in S.pneumoniae R6 = spr1548; hypothetical protein complement(1538169..1538960) Streptococcus pneumoniae D39 4442385 YP_816972.1 CDS SPD_1517 NC_008533.1 1538982 1539374 R equivalent gene in S.pneumoniae R6 = spr1549; hypothetical protein complement(1538982..1539374) Streptococcus pneumoniae D39 4442922 YP_816973.1 CDS SPD_1518 NC_008533.1 1539701 1540552 D equivalent gene in S.pneumoniae R6 = spr1550; identified by match to protein family HMM PF01381; match to protein family HMM TIGR01716; transcriptional activator, Rgg/GadR/MutR family protein 1539701..1540552 Streptococcus pneumoniae D39 4442927 YP_816974.1 CDS engA NC_008533.1 1541688 1542998 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1541688..1542998) Streptococcus pneumoniae D39 4441376 YP_816975.1 CDS SPD_1520 NC_008533.1 1543012 1543725 R equivalent gene in S.pneumoniae TIGR4 = SP1710; equivalent gene in S.pneumoniae R6 = spr1554; identified by match to protein family HMM PF00881; nitroreductase family protein complement(1543012..1543725) Streptococcus pneumoniae D39 4441925 YP_816976.1 CDS dnaI NC_008533.1 1543722 1544618 R Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI complement(1543722..1544618) Streptococcus pneumoniae D39 4441466 YP_816977.1 CDS SPD_1522 NC_008533.1 1544619 1545788 R equivalent gene in S.pneumoniae TIGR4 = SP1712; equivalent gene in S.pneumoniae R6 = spr1556; identified by match to protein family HMM PF07261; hypothetical protein complement(1544619..1545788) Streptococcus pneumoniae D39 4442640 YP_816978.1 CDS nrdR NC_008533.1 1545789 1546262 R equivalent gene in S.pneumoniae TIGR4 = SP1713; equivalent gene in S.pneumoniae R6 = spr1557; identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR complement(1545789..1546262) Streptococcus pneumoniae D39 4442319 YP_816979.1 CDS SPD_1524 NC_008533.1 1546402 1546767 D equivalent gene in S.pneumoniae TIGR4 = SP1714; equivalent gene in S.pneumoniae R6 = spr1558; identified by match to protein family HMM PF00392; GntR family transcriptional regulator protein 1546402..1546767 Streptococcus pneumoniae D39 4442245 YP_816980.1 CDS SPD_1525 NC_008533.1 1546772 1547467 D equivalent gene in S.pneumoniae TIGR4 = SP1715; equivalent gene in S.pneumoniae R6 = spr1559; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1546772..1547467 Streptococcus pneumoniae D39 4442423 YP_816981.1 CDS SPD_1526 NC_008533.1 1547484 1548251 D equivalent gene in S.pneumoniae TIGR4 = SP1715; equivalent gene in S.pneumoniae R6 = spr1560; hypothetical protein 1547484..1548251 Streptococcus pneumoniae D39 4441408 YP_816982.1 CDS SPD_1527 NC_008533.1 1548664 1549863 R equivalent gene in S.pneumoniae TIGR4 = SP1716; equivalent gene in S.pneumoniae R6 = spr1561; hypothetical protein complement(1548664..1549863) Streptococcus pneumoniae D39 4441981 YP_816983.1 CDS SPD_1528 NC_008533.1 1549860 1550753 R equivalent gene in S.pneumoniae TIGR4 = SP1717; equivalent gene in S.pneumoniae R6 = spr1562; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1549860..1550753) Streptococcus pneumoniae D39 4441137 YP_816984.1 CDS SPD_1530 NC_008533.1 1552062 1552679 D equivalent gene in S.pneumoniae TIGR4 = SP1720; equivalent gene in S.pneumoniae R6 = spr1564; hypothetical protein 1552062..1552679 Streptococcus pneumoniae D39 4441382 YP_816985.1 CDS scrK NC_008533.1 1552999 1553886 R equivalent gene in S.pneumoniae TIGR4 = SP1721; equivalent gene in S.pneumoniae R6 = spr1565; identified by match to protein family HMM PF00480; fructokinase complement(1552999..1553886) Streptococcus pneumoniae D39 4442285 YP_816986.1 CDS SPD_1532 NC_008533.1 1554035 1555918 R equivalent gene in S.pneumoniae TIGR4 = SP1722; equivalent gene in S.pneumoniae R6 = spr1566; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996; PTS system IIABC components complement(1554035..1555918) Streptococcus pneumoniae D39 4441888 YP_816987.1 CDS SPD_1533 NC_008533.1 1556045 1556242 R equivalent gene in S.pneumoniae TIGR4 = SP1723; hypothetical protein complement(1556045..1556242) Streptococcus pneumoniae D39 4441562 YP_816988.1 CDS scrB NC_008533.1 1556295 1557749 D equivalent gene in S.pneumoniae TIGR4 = SP1724; equivalent gene in S.pneumoniae R6 = spr1568; identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase 1556295..1557749 Streptococcus pneumoniae D39 4442978 YP_816989.1 CDS scrR NC_008533.1 1557730 1558695 D equivalent gene in S.pneumoniae TIGR4 = SP1725; equivalent gene in S.pneumoniae R6 = spr1569; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sucrose operon repressor 1557730..1558695 Streptococcus pneumoniae D39 4442770 YP_816990.1 CDS SPD_1536 NC_008533.1 1558730 1560004 R equivalent gene in S.pneumoniae TIGR4 = SP1726; equivalent gene in S.pneumoniae R6 = spr1570; identified by match to protein family HMM TIGR00532; hydroxymethylglutaryl-CoA reductase, degradative complement(1558730..1560004) Streptococcus pneumoniae D39 4442305 YP_816991.1 CDS mvaS NC_008533.1 1560004 1561200 R equivalent gene in S.pneumoniae TIGR4 = SP1727; equivalent gene in S.pneumoniae R6 = spr1571; identified by match to protein family HMM PF01154; match to protein family HMM TIGR01835; hydroxymethylglutaryl-CoA synthase complement(1560004..1561200) Streptococcus pneumoniae D39 4441619 YP_816992.1 CDS SPD_1538 NC_008533.1 1561307 1561594 R equivalent gene in S.pneumoniae TIGR4 = SP1728; equivalent gene in S.pneumoniae R6 = spr1572; hypothetical protein complement(1561307..1561594) Streptococcus pneumoniae D39 4441548 YP_816993.1 CDS SPD_1540 NC_008533.1 1562311 1562760 R equivalent gene in S.pneumoniae TIGR4 = SP1730; equivalent gene in S.pneumoniae R6 = spr1575; hypothetical protein complement(1562311..1562760) Streptococcus pneumoniae D39 4441037 YP_816994.1 CDS SPD_1541 NC_008533.1 1562762 1563520 R equivalent gene in S.pneumoniae TIGR4 = SP1731; equivalent gene in S.pneumoniae R6 = spr1576; identified by match to protein family HMM PF06738; hypothetical protein complement(1562762..1563520) Streptococcus pneumoniae D39 4441773 YP_816995.1 CDS SPD_1542 NC_008533.1 1563635 1565614 R equivalent gene in S.pneumoniae TIGR4 = SP1732; equivalent gene in S.pneumoniae R6 = spr1577; identified by match to protein family HMM PF00069; match to protein family HMM PF01163; match to protein family HMM PF03793; serine/threonine protein kinase complement(1563635..1565614) Streptococcus pneumoniae D39 4441819 YP_816996.1 CDS SPD_1543 NC_008533.1 1565611 1566351 R equivalent gene in S.pneumoniae TIGR4 = SP1733; equivalent gene in S.pneumoniae R6 = spr1578; identified by match to protein family HMM PF00481; phosphatase complement(1565611..1566351) Streptococcus pneumoniae D39 4441334 YP_816997.1 CDS sun NC_008533.1 1566366 1567679 R equivalent gene in S.pneumoniae TIGR4 = SP1734; equivalent gene in S.pneumoniae R6 = spr1579; identified by match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563; ribosomal RNA small subunit methyltransferase B complement(1566366..1567679) Streptococcus pneumoniae D39 4442344 YP_816998.1 CDS fmt NC_008533.1 1567672 1568607 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1567672..1568607) Streptococcus pneumoniae D39 4441669 YP_816999.1 CDS priA NC_008533.1 1568620 1571016 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1568620..1571016) Streptococcus pneumoniae D39 4442914 YP_817000.1 CDS SPD_1547 NC_008533.1 1571082 1571396 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1571082..1571396) Streptococcus pneumoniae D39 4441196 YP_817001.1 CDS gmk NC_008533.1 1571421 1572047 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1571421..1572047) Streptococcus pneumoniae D39 4443062 YP_817002.1 CDS SPD_1549 NC_008533.1 1572177 1573790 R equivalent gene in S.pneumoniae TIGR4 = SP1739; equivalent gene in S.pneumoniae R6 = spr1584; identified by match to protein family HMM PF00013; match to protein family HMM PF01966; match to protein family HMM TIGR00277; hypothetical protein complement(1572177..1573790) Streptococcus pneumoniae D39 4442112 YP_817003.1 CDS SPD_1550 NC_008533.1 1573981 1574235 R equivalent gene in S.pneumoniae TIGR4 = SP1740; equivalent gene in S.pneumoniae R6 = spr1585; identified by match to protein family HMM PF06769; match to protein family HMM TIGR02116; hypothetical protein complement(1573981..1574235) Streptococcus pneumoniae D39 4441130 YP_817004.1 CDS SPD_1551 NC_008533.1 1574239 1574499 R equivalent gene in S.pneumoniae TIGR4 = SP1741; equivalent gene in S.pneumoniae R6 = spr1586; identified by match to protein family HMM PF02604; match to protein family HMM TIGR01552; hypothetical protein complement(1574239..1574499) Streptococcus pneumoniae D39 4442026 YP_817005.1 CDS SPD_1552 NC_008533.1 1574731 1575828 R equivalent gene in S.pneumoniae TIGR4 = SP1742; equivalent gene in S.pneumoniae R6 = spr1587; identified by match to protein family HMM PF05636; hypothetical protein complement(1574731..1575828) Streptococcus pneumoniae D39 4442676 YP_817006.1 CDS SPD_1553 NC_008533.1 1575838 1576584 R equivalent gene in S.pneumoniae TIGR4 = SP1743; equivalent gene in S.pneumoniae R6 = spr1588; hypothetical protein complement(1575838..1576584) Streptococcus pneumoniae D39 4441940 YP_817007.1 CDS SPD_1554 NC_008533.1 1576687 1577040 R equivalent gene in S.pneumoniae TIGR4 = SP1744; equivalent gene in S.pneumoniae R6 = spr1589; identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; iojap-like protein complement(1576687..1577040) Streptococcus pneumoniae D39 4442727 YP_817008.1 CDS SPD_1555 NC_008533.1 1577053 1577553 R equivalent gene in S.pneumoniae TIGR4 = SP1745; equivalent gene in S.pneumoniae R6 = spr1590; identified by match to protein family HMM PF00857; isochorismatase family protein complement(1577053..1577553) Streptococcus pneumoniae D39 4442316 YP_817009.1 CDS SPD_1556 NC_008533.1 1577554 1578147 R equivalent gene in S.pneumoniae TIGR4 = SP1746; equivalent gene in S.pneumoniae R6 = spr1591; identified by match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR00488; hypothetical protein complement(1577554..1578147) Streptococcus pneumoniae D39 4441169 YP_817010.1 CDS nadD NC_008533.1 1578147 1578776 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1578147..1578776) Streptococcus pneumoniae D39 4441125 YP_817011.1 CDS SPD_1558 NC_008533.1 1578828 1579139 R equivalent gene in S.pneumoniae TIGR4 = SP1748; equivalent gene in S.pneumoniae R6 = spr1593; identified by match to protein family HMM PF01985; match to protein family HMM TIGR00253; hypothetical protein complement(1578828..1579139) Streptococcus pneumoniae D39 4441321 YP_817012.1 CDS SPD_1559 NC_008533.1 1579354 1580460 R in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH complement(1579354..1580460) Streptococcus pneumoniae D39 4442598 YP_817013.1 CDS SPD_1560 NC_008533.1 1580463 1580990 R equivalent gene in S.pneumoniae TIGR4 = SP1750; equivalent gene in S.pneumoniae R6 = spr1595; identified by match to protein family HMM TIGR01662; match to protein family HMM TIGR01668; hypothetical protein complement(1580463..1580990) Streptococcus pneumoniae D39 4441805 YP_817014.1 CDS SPD_1561 NC_008533.1 1581005 1581901 R equivalent gene in S.pneumoniae TIGR4 = SP1751; equivalent gene in S.pneumoniae R6 = spr1596; identified by match to protein family HMM PF01544; magnesium transporter CorA family protein complement(1581005..1581901) Streptococcus pneumoniae D39 4442504 YP_817015.1 CDS SPD_1562 NC_008533.1 1581958 1582554 R equivalent gene in S.pneumoniae TIGR4 = SP1752; equivalent gene in S.pneumoniae R6 = spr1597; identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel (MscS) family protein complement(1581958..1582554) Streptococcus pneumoniae D39 4442027 YP_817016.1 CDS SPD_1563 NC_008533.1 1582907 1583866 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1582907..1583866 Streptococcus pneumoniae D39 4442337 YP_817017.1 CDS SPD_1564 NC_008533.1 1583934 1584887 D equivalent gene in S.pneumoniae TIGR4 = SP1754; equivalent gene in S.pneumoniae R6 = spr1599; identified by match to protein family HMM PF06081; hypothetical protein 1583934..1584887 Streptococcus pneumoniae D39 4441877 YP_817018.1 CDS SPD_1565 NC_008533.1 1585031 1585411 D equivalent gene in S.pneumoniae TIGR4 = SP1774; equivalent gene in S.pneumoniae R6 = spr1600; identified by match to protein family HMM PF01047; transcriptional regulator 1585031..1585411 Streptococcus pneumoniae D39 4443066 YP_817019.1 CDS SPD_1566 NC_008533.1 1585429 1585731 D equivalent gene in S.pneumoniae TIGR4 = SP1775; equivalent gene in S.pneumoniae R6 = spr1601; hypothetical protein 1585429..1585731 Streptococcus pneumoniae D39 4442553 YP_817020.1 CDS trx NC_008533.1 1585748 1586062 D equivalent gene in S.pneumoniae TIGR4 = SP1776; equivalent gene in S.pneumoniae R6 = spr1602; identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 1585748..1586062 Streptococcus pneumoniae D39 4442233 YP_817021.1 CDS SPD_1568 NC_008533.1 1586556 1586900 D equivalent gene in S.pneumoniae TIGR4 = SP1777; equivalent gene in S.pneumoniae R6 = spr1603; identified by match to protein family HMM PF01227; GTP cyclohydrolase 1586556..1586900 Streptococcus pneumoniae D39 4442784 YP_817022.1 CDS SPD_1569 NC_008533.1 1587380 1588048 R equivalent gene in S.pneumoniae TIGR4 = SP1778; equivalent gene in S.pneumoniae R6 = spr1604; identified by match to protein family HMM PF00230; aquaporin complement(1587380..1588048) Streptococcus pneumoniae D39 4441021 YP_817023.1 CDS SPD_1570 NC_008533.1 1588159 1588713 R equivalent gene in S.pneumoniae TIGR4 = SP1779; equivalent gene in S.pneumoniae R6 = spr1605; hypothetical protein complement(1588159..1588713) Streptococcus pneumoniae D39 4441173 YP_817024.1 CDS SPD_1571 NC_008533.1 1588959 1590755 R equivalent gene in S.pneumoniae TIGR4 = SP1780; equivalent gene in S.pneumoniae R6 = spr1606; identified by match to protein family HMM PF01432; match to protein family HMM TIGR00181; oligoendopeptidase F complement(1588959..1590755) Streptococcus pneumoniae D39 4442108 YP_817025.1 CDS SPD_1572 NC_008533.1 1590766 1591509 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1590766..1591509) Streptococcus pneumoniae D39 4441433 YP_817026.1 CDS prmA NC_008533.1 1591511 1592461 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase complement(1591511..1592461) Streptococcus pneumoniae D39 4443051 YP_817027.1 CDS SPD_1574 NC_008533.1 1592599 1593027 R equivalent gene in S.pneumoniae R6 = spr1609; identified by match to protein family HMM PF00293; MutT/nudix family protein complement(1592599..1593027) Streptococcus pneumoniae D39 4442740 YP_817028.1 CDS SPD_1575 NC_008533.1 1592993 1594096 R equivalent gene in S.pneumoniae TIGR4 = SP1784; equivalent gene in S.pneumoniae R6 = spr1610; identified by match to protein family HMM PF02163; hypothetical protein complement(1592993..1594096) Streptococcus pneumoniae D39 4441905 YP_817029.1 CDS SPD_1576 NC_008533.1 1594115 1594585 R equivalent gene in S.pneumoniae TIGR4 = SP1785; equivalent gene in S.pneumoniae R6 = spr1611; hypothetical protein complement(1594115..1594585) Streptococcus pneumoniae D39 4441124 YP_817030.1 CDS SPD_1577 NC_008533.1 1594876 1595328 R equivalent gene in S.pneumoniae TIGR4 = SP1786; equivalent gene in S.pneumoniae R6 = spr1612; identified by match to protein family HMM PF03681; hypothetical protein complement(1594876..1595328) Streptococcus pneumoniae D39 4442498 YP_817031.1 CDS SPD_1578 NC_008533.1 1595681 1595860 R equivalent gene in S.pneumoniae R6 = spr1614; hypothetical protein complement(1595681..1595860) Streptococcus pneumoniae D39 4442607 YP_817032.1 CDS SPD_1579 NC_008533.1 1596025 1596264 R equivalent gene in S.pneumoniae TIGR4 = SP1789; equivalent gene in S.pneumoniae R6 = spr1615; hypothetical protein complement(1596025..1596264) Streptococcus pneumoniae D39 4441441 YP_817033.1 CDS SPD_1580 NC_008533.1 1596534 1597805 D equivalent gene in S.pneumoniae TIGR4 = SP1790; equivalent gene in S.pneumoniae R6 = spr1616; identified by match to protein family HMM PF00004; recombination factor protein RarA 1596534..1597805 Streptococcus pneumoniae D39 4442320 YP_817034.1 CDS SPD_1582 NC_008533.1 1598352 1599671 R equivalent gene in S.pneumoniae TIGR4 = SP1795; equivalent gene in S.pneumoniae R6 = spr1617; identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase complement(1598352..1599671) Streptococcus pneumoniae D39 4441804 YP_817035.1 CDS SPD_1583 NC_008533.1 1599681 1600526 R equivalent gene in S.pneumoniae R6 = spr1618; identified by match to protein family HMM PF00528; ABC transporter permease complement(1599681..1600526) Streptococcus pneumoniae D39 4441631 YP_817036.1 CDS SPD_1584 NC_008533.1 1600528 1601430 R equivalent gene in S.pneumoniae R6 = spr1619; identified by match to protein family HMM PF00528; ABC transporter permease complement(1600528..1601430) Streptococcus pneumoniae D39 4441444 YP_817037.1 CDS SPD_1585 NC_008533.1 1601526 1602836 R equivalent gene in S.pneumoniae R6 = spr1620; identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein complement(1601526..1602836) Streptococcus pneumoniae D39 4442021 YP_817038.1 CDS SPD_1586 NC_008533.1 1602963 1603958 R equivalent gene in S.pneumoniae R6 = spr1621; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; LacI family transcriptional regulator complement(1602963..1603958) Streptococcus pneumoniae D39 4442719 YP_817039.1 CDS SPD_1587 NC_008533.1 1604320 1605801 R equivalent gene in S.pneumoniae TIGR4 = SP1800; equivalent gene in S.pneumoniae R6 = spr1622; identified by match to protein family HMM PF05043; transcriptional activator complement(1604320..1605801) Streptococcus pneumoniae D39 4442589 YP_817040.1 CDS SPD_1588 NC_008533.1 1606491 1607057 D equivalent gene in S.pneumoniae TIGR4 = SP1802; equivalent gene in S.pneumoniae R6 = spr1623; hypothetical protein 1606491..1607057 Streptococcus pneumoniae D39 4442215 YP_817041.1 CDS SPD_1589 NC_008533.1 1607069 1607239 D equivalent gene in S.pneumoniae TIGR4 = SP1803; equivalent gene in S.pneumoniae R6 = spr1624; hypothetical protein 1607069..1607239 Streptococcus pneumoniae D39 4442726 YP_817042.1 CDS SPD_1590 NC_008533.1 1607278 1607886 D equivalent gene in S.pneumoniae TIGR4 = SP1804; equivalent gene in S.pneumoniae R6 = spr1625; identified by match to protein family HMM PF03780; general stress protein 24 1607278..1607886 Streptococcus pneumoniae D39 4442788 YP_817043.1 CDS SPD_1591 NC_008533.1 1607917 1608120 D equivalent gene in S.pneumoniae TIGR4 = SP1805; equivalent gene in S.pneumoniae R6 = spr1626; identified by match to protein family HMM PF05532; hypothetical protein 1607917..1608120 Streptococcus pneumoniae D39 4442783 YP_817044.1 CDS SPD_1592 NC_008533.1 1608647 1609093 R equivalent gene in S.pneumoniae TIGR4 = SP1807; equivalent gene in S.pneumoniae R6 = spr1627; identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1608647..1609093) Streptococcus pneumoniae D39 4441997 YP_817045.1 CDS SPD_1593 NC_008533.1 1609163 1609822 D equivalent gene in S.pneumoniae TIGR4 = SP1808; equivalent gene in S.pneumoniae R6 = spr1628; identified by match to protein family HMM PF01478; match to protein family HMM PF06750; type IV prepilin peptidase 1609163..1609822 Streptococcus pneumoniae D39 4441468 YP_817046.1 CDS SPD_1594 NC_008533.1 1609874 1611025 R equivalent gene in S.pneumoniae TIGR4 = SP1809; equivalent gene in S.pneumoniae R6 = spr1629; identified by match to protein family HMM PF01381; match to protein family HMM PF06114; transcriptional regulator complement(1609874..1611025) Streptococcus pneumoniae D39 4442214 YP_817047.1 CDS SPD_1595 NC_008533.1 1611040 1611771 R equivalent gene in S.pneumoniae TIGR4 = SP1810; equivalent gene in S.pneumoniae R6 = spr1630; hypothetical protein complement(1611040..1611771) Streptococcus pneumoniae D39 4442364 YP_817048.1 CDS trpA NC_008533.1 1612073 1612849 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1612073..1612849) Streptococcus pneumoniae D39 4442671 YP_817049.1 CDS trpB NC_008533.1 1612842 1614065 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1612842..1614065) Streptococcus pneumoniae D39 4442400 YP_817050.1 CDS trpF NC_008533.1 1614043 1614642 R catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase complement(1614043..1614642) Streptococcus pneumoniae D39 4441409 YP_817051.1 CDS trpC NC_008533.1 1614629 1615396 R involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase complement(1614629..1615396) Streptococcus pneumoniae D39 4442158 YP_817052.1 CDS trpD NC_008533.1 1615393 1616397 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(1615393..1616397) Streptococcus pneumoniae D39 4442608 YP_817053.1 CDS trpG NC_008533.1 1616408 1616974 R TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II complement(1616408..1616974) Streptococcus pneumoniae D39 4442532 YP_817054.1 CDS trpE NC_008533.1 1616971 1618332 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1616971..1618332) Streptococcus pneumoniae D39 4442037 YP_817055.1 CDS SPD_1603 NC_008533.1 1618467 1618622 R equivalent gene in S.pneumoniae R6 = spr1638; hypothetical protein complement(1618467..1618622) Streptococcus pneumoniae D39 4442432 YP_817056.1 CDS SPD_1604 NC_008533.1 1618626 1618745 R hypothetical protein complement(1618626..1618745) Streptococcus pneumoniae D39 4441123 YP_817057.1 CDS SPD_1605 NC_008533.1 1619519 1620520 R equivalent gene in S.pneumoniae TIGR4 = SP1821; equivalent gene in S.pneumoniae R6 = spr1639; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; LacI family transcriptional regulator complement(1619519..1620520) Streptococcus pneumoniae D39 4442318 YP_817058.1 CDS SPD_1606 NC_008533.1 1621092 1621802 R equivalent gene in S.pneumoniae TIGR4 = SP1823; equivalent gene in S.pneumoniae R6 = spr1641; identified by match to protein family HMM PF02308; MgtC/SapB family protein complement(1621092..1621802) Streptococcus pneumoniae D39 4442714 YP_817059.1 CDS SPD_1607 NC_008533.1 1621805 1623496 R equivalent gene in S.pneumoniae TIGR4 = SP1824; equivalent gene in S.pneumoniae R6 = spr1643; identified by match to protein family HMM PF00528; ABC transporter permease complement(1621805..1623496) Streptococcus pneumoniae D39 4443009 YP_817060.1 CDS SPD_1608 NC_008533.1 1623508 1624518 R equivalent gene in S.pneumoniae TIGR4 = SP1825; equivalent gene in S.pneumoniae R6 = spr1644; identified by match to protein family HMM PF00005; match to protein family HMM PF03459; ABC transporter ATP-binding protein complement(1623508..1624518) Streptococcus pneumoniae D39 4442830 YP_817061.1 CDS SPD_1609 NC_008533.1 1624621 1625688 R equivalent gene in S.pneumoniae TIGR4 = SP1826; equivalent gene in S.pneumoniae R6 = spr1645; ABC transporter substrate-binding protein complement(1624621..1625688) Streptococcus pneumoniae D39 4442497 YP_817062.1 CDS SPD_1610 NC_008533.1 1625713 1626372 R equivalent gene in S.pneumoniae TIGR4 = SP1827; equivalent gene in S.pneumoniae R6 = spr1646; hypothetical protein complement(1625713..1626372) Streptococcus pneumoniae D39 4442682 YP_817063.1 CDS SPD_1611 NC_008533.1 1626500 1626613 R hypothetical protein complement(1626500..1626613) Streptococcus pneumoniae D39 4441866 YP_817064.1 CDS galE-2 NC_008533.1 1626582 1627562 R equivalent gene in S.pneumoniae TIGR4 = SP1828; equivalent gene in S.pneumoniae R6 = spr1647; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase complement(1626582..1627562) Streptococcus pneumoniae D39 4442878 YP_817065.1 CDS galT-1 NC_008533.1 1627575 1629050 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1627575..1629050) Streptococcus pneumoniae D39 4442034 YP_817066.1 CDS SPD_1614 NC_008533.1 1629063 1629704 R equivalent gene in S.pneumoniae TIGR4 = SP1830; equivalent gene in S.pneumoniae R6 = spr1649; phosphate transport system regulatory protein PhoU complement(1629063..1629704) Streptococcus pneumoniae D39 4442949 YP_817067.1 CDS SPD_1615 NC_008533.1 1629762 1630256 R equivalent gene in S.pneumoniae TIGR4 = SP1831; equivalent gene in S.pneumoniae R6 = spr1650; hypothetical protein complement(1629762..1630256) Streptococcus pneumoniae D39 4441215 YP_817068.1 CDS SPD_1616 NC_008533.1 1630317 1630613 R equivalent gene in S.pneumoniae TIGR4 = SP1832; equivalent gene in S.pneumoniae R6 = spr1651; hypothetical protein complement(1630317..1630613) Streptococcus pneumoniae D39 4442528 YP_817069.1 CDS SPD_1617 NC_008533.1 1630597 1632723 R equivalent gene in S.pneumoniae TIGR4 = SP1833; equivalent gene in S.pneumoniae R6 = spr1652; identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; cell wall surface anchor family protein complement(1630597..1632723) Streptococcus pneumoniae D39 4441161 YP_817070.1 CDS SPD_1618 NC_008533.1 1633669 1633845 D equivalent gene in S.pneumoniae TIGR4 = SP1836; equivalent gene in S.pneumoniae R6 = spr1653; hypothetical protein 1633669..1633845 Streptococcus pneumoniae D39 4441812 YP_817071.1 CDS SPD_1619 NC_008533.1 1633887 1635113 R equivalent gene in S.pneumoniae TIGR4 = SP1837; equivalent gene in S.pneumoniae R6 = spr1654; identified by match to protein family HMM PF01041; capsular polysaccharide biosynthesis protein complement(1633887..1635113) Streptococcus pneumoniae D39 4441645 YP_817072.1 CDS SPD_1620 NC_008533.1 1635156 1635848 R equivalent gene in S.pneumoniae TIGR4 = SP1838; equivalent gene in S.pneumoniae R6 = spr1655; identified by match to protein family HMM PF02397; glycosyl transferase family protein complement(1635156..1635848) Streptococcus pneumoniae D39 4441975 YP_817073.1 CDS SPD_1621 NC_008533.1 1636021 1637772 R equivalent gene in S.pneumoniae TIGR4 = SP1839; equivalent gene in S.pneumoniae R6 = spr1656; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1636021..1637772) Streptococcus pneumoniae D39 4442520 YP_817074.1 CDS SPD_1622 NC_008533.1 1637762 1639507 R equivalent gene in S.pneumoniae TIGR4 = SP1840; equivalent gene in S.pneumoniae R6 = spr1657; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1637762..1639507) Streptococcus pneumoniae D39 4442406 YP_817075.1 CDS SPD_1623 NC_008533.1 1639635 1640165 R equivalent gene in S.pneumoniae TIGR4 = SP1841; equivalent gene in S.pneumoniae R6 = spr1658; identified by match to protein family HMM PF04239; hypothetical protein complement(1639635..1640165) Streptococcus pneumoniae D39 4441129 YP_817076.1 CDS SPD_1624 NC_008533.1 1640162 1640431 R equivalent gene in S.pneumoniae TIGR4 = SP1842; equivalent gene in S.pneumoniae R6 = spr1659; hypothetical protein complement(1640162..1640431) Streptococcus pneumoniae D39 4441297 YP_817077.1 CDS SPD_1625 NC_008533.1 1640391 1640618 R equivalent gene in S.pneumoniae TIGR4 = SP1844; hypothetical protein complement(1640391..1640618) Streptococcus pneumoniae D39 4442100 YP_817078.1 CDS xth NC_008533.1 1640752 1641579 D equivalent gene in S.pneumoniae TIGR4 = SP1845; equivalent gene in S.pneumoniae R6 = spr1660; identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease III 1640752..1641579 Streptococcus pneumoniae D39 4442758 YP_817079.1 CDS xpt NC_008533.1 1642851 1643432 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1642851..1643432 Streptococcus pneumoniae D39 4442859 YP_817080.1 CDS pbuX NC_008533.1 1643432 1644694 D equivalent gene in S.pneumoniae TIGR4 = SP1848; equivalent gene in S.pneumoniae R6 = spr1663; identified by match to protein family HMM PF00860; match to protein family HMM PF00916; match to protein family HMM TIGR00801; xanthine permease 1643432..1644694 Streptococcus pneumoniae D39 4441998 YP_817081.1 CDS SPD_1630 NC_008533.1 1644745 1645206 R equivalent gene in S.pneumoniae TIGR4 = SP1849; equivalent gene in S.pneumoniae R6 = spr1664; hypothetical protein complement(1644745..1645206) Streptococcus pneumoniae D39 4441100 YP_817082.1 CDS SPD_1631 NC_008533.1 1645203 1645967 R equivalent gene in S.pneumoniae TIGR4 = SP1850; equivalent gene in S.pneumoniae R6 = spr1665; identified by match to protein family HMM PF06044; Dam-replacing family protein complement(1645203..1645967) Streptococcus pneumoniae D39 4442106 YP_817083.1 CDS SPD_1632 NC_008533.1 1646148 1646552 R equivalent gene in S.pneumoniae TIGR4 = SP1851; equivalent gene in S.pneumoniae R6 = spr1666; identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein complement(1646148..1646552) Streptococcus pneumoniae D39 4441510 YP_817084.1 CDS galT-2 NC_008533.1 1646622 1648103 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1646622..1648103) Streptococcus pneumoniae D39 4441840 YP_817085.1 CDS galK NC_008533.1 1648122 1649300 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(1648122..1649300) Streptococcus pneumoniae D39 4442502 YP_817086.1 CDS galR NC_008533.1 1649464 1650471 D equivalent gene in S.pneumoniae TIGR4 = SP1854; equivalent gene in S.pneumoniae R6 = spr1669; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; galactose operon repressor 1649464..1650471 Streptococcus pneumoniae D39 4442722 YP_817087.1 CDS SPD_1636 NC_008533.1 1650517 1651554 R equivalent gene in S.pneumoniae TIGR4 = SP1855; equivalent gene in S.pneumoniae R6 = spr1670; identified by match to protein family HMM PF00107; zinc-containing alcohol dehydrogenase complement(1650517..1651554) Streptococcus pneumoniae D39 4443044 YP_817088.1 CDS SPD_1637 NC_008533.1 1651555 1651908 R equivalent gene in S.pneumoniae TIGR4 = SP1856; equivalent gene in S.pneumoniae R6 = spr1671; identified by match to protein family HMM PF00376; transcriptional regulator, MerR family protein complement(1651555..1651908) Streptococcus pneumoniae D39 4441026 YP_817089.1 CDS SPD_1638 NC_008533.1 1652152 1653042 R equivalent gene in S.pneumoniae TIGR4 = SP1857; equivalent gene in S.pneumoniae R6 = spr1672; identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux system protein complement(1652152..1653042) Streptococcus pneumoniae D39 4442910 YP_817090.1 CDS SPD_1639 NC_008533.1 1653175 1653711 D equivalent gene in S.pneumoniae TIGR4 = SP1858; equivalent gene in S.pneumoniae R6 = spr1673; identified by match to protein family HMM PF00440; transcriptional regulator, TetR family protein 1653175..1653711 Streptococcus pneumoniae D39 4442444 YP_817091.1 CDS pnuC NC_008533.1 1653878 1654684 R equivalent gene in S.pneumoniae TIGR4 = SP1859; equivalent gene in S.pneumoniae R6 = spr1674; identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter PnuC complement(1653878..1654684) Streptococcus pneumoniae D39 4441191 YP_817092.1 CDS proWX NC_008533.1 1656513 1658033 R equivalent gene in S.pneumoniae TIGR4 = SP1860; equivalent gene in S.pneumoniae R6 = spr1677; identified by match to protein family HMM PF00528; match to protein family HMM PF04069; choline transporter (glycine betaine transport system permease) complement(1656513..1658033) Streptococcus pneumoniae D39 4442451 YP_817093.1 CDS proV NC_008533.1 1658026 1658754 R equivalent gene in S.pneumoniae TIGR4 = SP1861; equivalent gene in S.pneumoniae R6 = spr1678; identified by match to protein family HMM PF00005; choline transporter complement(1658026..1658754) Streptococcus pneumoniae D39 4442496 YP_817094.1 CDS SPD_1644 NC_008533.1 1658769 1659533 R equivalent gene in S.pneumoniae TIGR4 = SP1862; equivalent gene in S.pneumoniae R6 = spr1679; identified by match to protein family HMM PF07366; hypothetical protein complement(1658769..1659533) Streptococcus pneumoniae D39 4441651 YP_817095.1 CDS SPD_1645 NC_008533.1 1659537 1659980 R equivalent gene in S.pneumoniae TIGR4 = SP1863; equivalent gene in S.pneumoniae R6 = spr1680; identified by match to protein family HMM PF01047; transcriptional regulator, MarR family protein complement(1659537..1659980) Streptococcus pneumoniae D39 4442522 YP_817096.1 CDS SPD_1646 NC_008533.1 1660662 1660958 R equivalent gene in S.pneumoniae TIGR4 = SP1864; equivalent gene in S.pneumoniae R6 = spr1681; hypothetical protein complement(1660662..1660958) Streptococcus pneumoniae D39 4442194 YP_817097.1 CDS pepA NC_008533.1 1660980 1662044 R equivalent gene in S.pneumoniae TIGR4 = SP1865; equivalent gene in S.pneumoniae R6 = spr1682; identified by match to protein family HMM PF05343; glutamyl aminopeptidase PepA complement(1660980..1662044) Streptococcus pneumoniae D39 4441461 YP_817098.1 CDS SPD_1648 NC_008533.1 1662445 1663146 D equivalent gene in S.pneumoniae TIGR4 = SP1867; equivalent gene in S.pneumoniae R6 = spr1683; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; NAD-dependent epimerase/dehydratase family protein 1662445..1663146 Streptococcus pneumoniae D39 4442885 YP_817099.1 CDS SPD_1649 NC_008533.1 1663569 1664528 D equivalent gene in S.pneumoniae TIGR4 = SP1869; equivalent gene in S.pneumoniae R6 = spr1684; identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1663569..1664528 Streptococcus pneumoniae D39 4441057 YP_817100.1 CDS SPD_1650 NC_008533.1 1664518 1665474 D equivalent gene in S.pneumoniae TIGR4 = SP1870; equivalent gene in S.pneumoniae R6 = spr1685; identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1664518..1665474 Streptococcus pneumoniae D39 4441963 YP_817101.1 CDS SPD_1651 NC_008533.1 1665471 1666223 D equivalent gene in S.pneumoniae TIGR4 = SP1871; equivalent gene in S.pneumoniae R6 = spr1686; identified by match to protein family HMM PF00005; iron-compound ABC transporter ATP-binding protein 1665471..1666223 Streptococcus pneumoniae D39 4441398 YP_817102.1 CDS SPD_1652 NC_008533.1 1666319 1667284 D equivalent gene in S.pneumoniae TIGR4 = SP1872; equivalent gene in S.pneumoniae R6 = spr1687; identified by match to protein family HMM PF01497; iron-compound ABC transporter iron-compound-binding protein 1666319..1667284 Streptococcus pneumoniae D39 4441089 YP_817103.1 CDS SPD_1653 NC_008533.1 1667509 1667751 R equivalent gene in S.pneumoniae TIGR4 = SP1873; equivalent gene in S.pneumoniae R6 = spr1688; identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein complement(1667509..1667751) Streptococcus pneumoniae D39 4441456 YP_817104.1 CDS rluB NC_008533.1 1667751 1668473 R equivalent gene in S.pneumoniae TIGR4 = SP1874; equivalent gene in S.pneumoniae R6 = spr1689; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal large subunit pseudouridine synthase B complement(1667751..1668473) Streptococcus pneumoniae D39 4441550 YP_817105.1 CDS scpB NC_008533.1 1668460 1669029 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B complement(1668460..1669029) Streptococcus pneumoniae D39 4441419 YP_817106.1 CDS scpA NC_008533.1 1669048 1669776 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A complement(1669048..1669776) Streptococcus pneumoniae D39 4441509 YP_817107.1 CDS xerD NC_008533.1 1669776 1670516 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(1669776..1670516) Streptococcus pneumoniae D39 4442354 YP_817108.1 CDS SPD_1658 NC_008533.1 1670507 1670968 R equivalent gene in S.pneumoniae TIGR4 = SP1878; equivalent gene in S.pneumoniae R6 = spr1693; identified by match to protein family HMM PF00571; hypothetical protein complement(1670507..1670968) Streptococcus pneumoniae D39 4441435 YP_817109.1 CDS SPD_1659 NC_008533.1 1670965 1671486 R equivalent gene in S.pneumoniae TIGR4 = SP1879; equivalent gene in S.pneumoniae R6 = spr1694; identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; hypothetical protein complement(1670965..1671486) Streptococcus pneumoniae D39 4442242 YP_817110.1 CDS SPD_1660 NC_008533.1 1671462 1672433 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein complement(1671462..1672433) Streptococcus pneumoniae D39 4441306 YP_817111.1 CDS murI NC_008533.1 1672430 1673224 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(1672430..1673224) Streptococcus pneumoniae D39 4441225 YP_817112.1 CDS SPD_1662 NC_008533.1 1673431 1673679 R equivalent gene in S.pneumoniae TIGR4 = SP1882; equivalent gene in S.pneumoniae R6 = spr1697; hypothetical protein complement(1673431..1673679) Streptococcus pneumoniae D39 4443034 YP_817113.1 CDS treC NC_008533.1 1673821 1675446 R equivalent gene in S.pneumoniae TIGR4 = SP1883; equivalent gene in S.pneumoniae R6 = spr1698; identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; alpha,alpha-phosphotrehalase complement(1673821..1675446) Streptococcus pneumoniae D39 4442894 YP_817114.1 CDS SPD_1664 NC_008533.1 1675624 1677591 R equivalent gene in S.pneumoniae TIGR4 = SP1884; equivalent gene in S.pneumoniae R6 = spr1699; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992; PTS system, trehalose-specific IIABC components complement(1675624..1677591) Streptococcus pneumoniae D39 4441930 YP_817115.1 CDS treR NC_008533.1 1677776 1678486 D equivalent gene in S.pneumoniae TIGR4 = SP1885; equivalent gene in S.pneumoniae R6 = spr1700; identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404; trehalose operon repressor 1677776..1678486 Streptococcus pneumoniae D39 4441497 YP_817116.1 CDS amiF NC_008533.1 1680023 1680949 R equivalent gene in S.pneumoniae TIGR4 = SP1887; equivalent gene in S.pneumoniae R6 = spr1703; identified by match to protein family HMM PF00005; oligopeptide ABC transporter ATP-binding protein AmiF complement(1680023..1680949) Streptococcus pneumoniae D39 4441260 YP_817117.1 CDS amiE NC_008533.1 1680960 1682027 R equivalent gene in S.pneumoniae TIGR4 = SP1888; equivalent gene in S.pneumoniae R6 = spr1704; identified by match to protein family HMM PF00005; match to protein family HMM TIGR01727; oligopeptide ABC transporter ATP-binding protein AmiE complement(1680960..1682027) Streptococcus pneumoniae D39 4441184 YP_817118.1 CDS amiD NC_008533.1 1682036 1682962 R equivalent gene in S.pneumoniae TIGR4 = SP1889; equivalent gene in S.pneumoniae R6 = spr1705; identified by match to protein family HMM PF00528; oligopeptide ABC transporter permease AmiD complement(1682036..1682962) Streptococcus pneumoniae D39 4442587 YP_817119.1 CDS amiC NC_008533.1 1682962 1684458 R equivalent gene in S.pneumoniae TIGR4 = SP1890; equivalent gene in S.pneumoniae R6 = spr1706; identified by match to protein family HMM PF00528; oligopeptide ABC transporter permease AmiC complement(1682962..1684458) Streptococcus pneumoniae D39 4441898 YP_817120.1 CDS amiA NC_008533.1 1684525 1686504 R equivalent gene in S.pneumoniae TIGR4 = SP1891; equivalent gene in S.pneumoniae R6 = spr1707; identified by match to protein family HMM PF00496; oligopeptide ABC transporter oligopeptide-binding protein AmiA complement(1684525..1686504) Streptococcus pneumoniae D39 4441155 YP_817121.1 CDS SPD_1672 NC_008533.1 1687191 1688384 R equivalent gene in S.pneumoniae TIGR4 = SP1893; equivalent gene in S.pneumoniae R6 = spr1708; identified by match to protein family HMM PF04932; hypothetical protein complement(1687191..1688384) Streptococcus pneumoniae D39 4442308 YP_817122.1 CDS gtfA NC_008533.1 1688522 1689964 R equivalent gene in S.pneumoniae TIGR4 = SP1894; equivalent gene in S.pneumoniae R6 = spr1709; identified by match to protein family HMM PF00128; sucrose phosphorylase complement(1688522..1689964) Streptococcus pneumoniae D39 4441327 YP_817123.1 CDS SPD_1674 NC_008533.1 1690148 1690315 R hypothetical protein complement(1690148..1690315) Streptococcus pneumoniae D39 4442045 YP_817124.1 CDS rafG NC_008533.1 1690322 1691155 R equivalent gene in S.pneumoniae TIGR4 = SP1895; equivalent gene in S.pneumoniae R6 = spr1710; identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1690322..1691155) Streptococcus pneumoniae D39 4441479 YP_817125.1 CDS rafF NC_008533.1 1691169 1692035 R equivalent gene in S.pneumoniae TIGR4 = SP1896; equivalent gene in S.pneumoniae R6 = spr1711; identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1691169..1692035) Streptococcus pneumoniae D39 4441899 YP_817126.1 CDS rafE NC_008533.1 1692049 1693308 R equivalent gene in S.pneumoniae TIGR4 = SP1897; equivalent gene in S.pneumoniae R6 = spr1712; identified by match to protein family HMM PF01547; sugar ABC transporter sugar-binding protein complement(1692049..1693308) Streptococcus pneumoniae D39 4442985 YP_817127.1 CDS aga NC_008533.1 1693400 1695562 R equivalent gene in S.pneumoniae TIGR4 = SP1898; equivalent gene in S.pneumoniae R6 = spr1713; identified by match to protein family HMM PF02065; alpha-galactosidase AgaN complement(1693400..1695562) Streptococcus pneumoniae D39 4442466 YP_817128.1 CDS msmR NC_008533.1 1695670 1696530 D equivalent gene in S.pneumoniae TIGR4 = SP1899; equivalent gene in S.pneumoniae R6 = spr1714; identified by match to protein family HMM PF00165; match to protein family HMM PF02311; msm operon regulatory protein MsmR 1695670..1696530 Streptococcus pneumoniae D39 4443084 YP_817129.1 CDS SPD_1680 NC_008533.1 1696527 1697462 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1696527..1697462 Streptococcus pneumoniae D39 4442254 YP_817130.1 CDS rumA-2 NC_008533.1 1705095 1706450 R equivalent gene in S.pneumoniae TIGR4 = SP1901; equivalent gene in S.pneumoniae R6 = spr1717; identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA complement(1705095..1706450) Streptococcus pneumoniae D39 4441649 YP_817131.1 CDS recX NC_008533.1 1706488 1707264 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1706488..1707264 Streptococcus pneumoniae D39 4442609 YP_817132.1 CDS SPD_1706 NC_008533.1 1707353 1707886 D equivalent gene in S.pneumoniae TIGR4 = SP1903; equivalent gene in S.pneumoniae R6 = spr1719; identified by match to protein family HMM PF04167; hypothetical protein 1707353..1707886 Streptococcus pneumoniae D39 4442562 YP_817133.1 CDS SPD_1707 NC_008533.1 1708240 1708446 R equivalent gene in S.pneumoniae TIGR4 = SP1904; equivalent gene in S.pneumoniae R6 = spr1720; hypothetical protein complement(1708240..1708446) Streptococcus pneumoniae D39 4442421 YP_817134.1 CDS SPD_1708 NC_008533.1 1708606 1709835 D equivalent gene in S.pneumoniae TIGR4 = SP1262; equivalent gene in S.pneumoniae R6 = spr1721; identified by match to protein family HMM PF01610; IS1167, transposase 1708606..1709835 Streptococcus pneumoniae D39 4442246 YP_817135.1 CDS groEL NC_008533.1 1709934 1711556 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(1709934..1711556) Streptococcus pneumoniae D39 4441425 YP_817136.1 CDS groES NC_008533.1 1711572 1711856 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1711572..1711856) Streptococcus pneumoniae D39 4442043 YP_817137.1 CDS SPD_1711 NC_008533.1 1712012 1712407 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1712012..1712407) Streptococcus pneumoniae D39 4442861 YP_817138.1 CDS SPD_1712 NC_008533.1 1712485 1713246 R equivalent gene in S.pneumoniae TIGR4 = SP1909; equivalent gene in S.pneumoniae R6 = spr1725; identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase family oxidoreductase complement(1712485..1713246) Streptococcus pneumoniae D39 4442964 YP_817139.1 CDS SPD_1713 NC_008533.1 1713279 1713905 R equivalent gene in S.pneumoniae TIGR4 = SP1910; equivalent gene in S.pneumoniae R6 = spr1726; identified by match to protein family HMM PF01588; hypothetical protein complement(1713279..1713905) Streptococcus pneumoniae D39 4442750 YP_817140.1 CDS SPD_1714 NC_008533.1 1713921 1714238 R equivalent gene in S.pneumoniae TIGR4 = SP1911; equivalent gene in S.pneumoniae R6 = spr1727; identified by match to protein family HMM PF00085; thioredoxin family protein complement(1713921..1714238) Streptococcus pneumoniae D39 4441934 YP_817141.1 CDS SPD_1715 NC_008533.1 1714235 1714534 R equivalent gene in S.pneumoniae TIGR4 = SP1912; equivalent gene in S.pneumoniae R6 = spr1728; hypothetical protein complement(1714235..1714534) Streptococcus pneumoniae D39 4441527 YP_817142.1 CDS SPD_1716 NC_008533.1 1714871 1715062 R equivalent gene in S.pneumoniae R6 = spr1729; identified by match to protein family HMM PF01473; hypothetical protein complement(1714871..1715062) Streptococcus pneumoniae D39 4441240 YP_817143.1 CDS SPD_1717 NC_008533.1 1715223 1715897 R equivalent gene in S.pneumoniae TIGR4 = SP1914; equivalent gene in S.pneumoniae R6 = spr1730; hypothetical protein complement(1715223..1715897) Streptococcus pneumoniae D39 4442632 YP_817144.1 CDS SPD_1718 NC_008533.1 1715903 1716349 R equivalent gene in S.pneumoniae TIGR4 = SP1915; equivalent gene in S.pneumoniae R6 = spr1731; identified by match to protein family HMM PF04397; hypothetical protein complement(1715903..1716349) Streptococcus pneumoniae D39 4441496 YP_817145.1 CDS SPD_1719 NC_008533.1 1716463 1716966 R equivalent gene in S.pneumoniae TIGR4 = SP1916; equivalent gene in S.pneumoniae R6 = spr1732; identified by match to protein family HMM PF01569; PAP2 family protein complement(1716463..1716966) Streptococcus pneumoniae D39 4441262 YP_817146.1 CDS SPD_1720 NC_008533.1 1716963 1717325 R equivalent gene in S.pneumoniae TIGR4 = SP1917; equivalent gene in S.pneumoniae R6 = spr1733; hypothetical protein complement(1716963..1717325) Streptococcus pneumoniae D39 4441242 YP_817147.1 CDS SPD_1721 NC_008533.1 1717391 1718422 R equivalent gene in S.pneumoniae TIGR4 = SP1918; equivalent gene in S.pneumoniae R6 = spr1734; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1717391..1718422) Streptococcus pneumoniae D39 4441583 YP_817148.1 CDS SPD_1723 NC_008533.1 1719267 1719380 R hypothetical protein complement(1719267..1719380) Streptococcus pneumoniae D39 4442690 YP_817149.1 CDS SPD_1725 NC_008533.1 1719860 1720576 R equivalent gene in S.pneumoniae TIGR4 = SP1922; equivalent gene in S.pneumoniae R6 = spr1738; identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein complement(1719860..1720576) Streptococcus pneumoniae D39 4441854 YP_817150.1 CDS ply NC_008533.1 1721457 1722872 R equivalent gene in S.pneumoniae TIGR4 = SP1923; equivalent gene in S.pneumoniae R6 = spr1739; identified by match to protein family HMM PF01289; pneumolysin complement(1721457..1722872) Streptococcus pneumoniae D39 4441611 YP_817151.1 CDS SPD_1727 NC_008533.1 1722883 1723293 R equivalent gene in S.pneumoniae TIGR4 = SP1924; equivalent gene in S.pneumoniae R6 = spr1740; hypothetical protein complement(1722883..1723293) Streptococcus pneumoniae D39 4441220 YP_817152.1 CDS SPD_1728 NC_008533.1 1723286 1723894 R equivalent gene in S.pneumoniae TIGR4 = SP1925; equivalent gene in S.pneumoniae R6 = spr1741; hypothetical protein complement(1723286..1723894) Streptococcus pneumoniae D39 4442653 YP_817153.1 CDS SPD_1729 NC_008533.1 1723907 1724365 R equivalent gene in S.pneumoniae TIGR4 = SP1926; equivalent gene in S.pneumoniae R6 = spr1742 This gene has a frameshift at amaino acid 96 relative to its R6 equivalent gene but not its TIGR4 equivalent gene.; hypothetical protein complement(1723907..1724365) Streptococcus pneumoniae D39 4441112 YP_817154.1 CDS SPD_1731 NC_008533.1 1725654 1725914 R equivalent gene in S.pneumoniae TIGR4 = SP1930; equivalent gene in S.pneumoniae R6 = spr1746; hypothetical protein complement(1725654..1725914) Streptococcus pneumoniae D39 4441227 YP_817155.1 CDS SPD_1732 NC_008533.1 1725973 1726524 R equivalent gene in S.pneumoniae TIGR4 = SP1931; equivalent gene in S.pneumoniae R6 = spr1747; hypothetical protein complement(1725973..1726524) Streptococcus pneumoniae D39 4441231 YP_817156.1 CDS SPD_1733 NC_008533.1 1726514 1726711 R equivalent gene in S.pneumoniae TIGR4 = SP1932; equivalent gene in S.pneumoniae R6 = spr1748; hypothetical protein complement(1726514..1726711) Streptococcus pneumoniae D39 4442917 YP_817157.1 CDS SPD_1734 NC_008533.1 1726715 1727509 R equivalent gene in S.pneumoniae TIGR4 = SP1933; equivalent gene in S.pneumoniae R6 = spr1749; hypothetical protein complement(1726715..1727509) Streptococcus pneumoniae D39 4441992 YP_817158.1 CDS SPD_1735 NC_008533.1 1727917 1728342 R equivalent gene in S.pneumoniae TIGR4 = SP1934; equivalent gene in S.pneumoniae R6 = spr1750; hypothetical protein complement(1727917..1728342) Streptococcus pneumoniae D39 4441458 YP_817159.1 CDS SPD_1736 NC_008533.1 1728471 1728830 R equivalent gene in S.pneumoniae TIGR4 = SP1935; equivalent gene in S.pneumoniae R6 = spr1751; hypothetical protein complement(1728471..1728830) Streptococcus pneumoniae D39 4442841 YP_817160.1 CDS lytA NC_008533.1 1729601 1730557 R equivalent gene in S.pneumoniae TIGR4 = SP1937; equivalent gene in S.pneumoniae R6 = spr1754; identified by match to protein family HMM PF01473; match to protein family HMM PF01510; autolysin/N-acetylmuramoyl-L-alanine amidase complement(1729601..1730557) Streptococcus pneumoniae D39 4442230 YP_817161.1 CDS dinF NC_008533.1 1730933 1732303 R equivalent gene in S.pneumoniae TIGR4 = SP1939; equivalent gene in S.pneumoniae R6 = spr1756; identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; MATE efflux family protein DinF complement(1730933..1732303) Streptococcus pneumoniae D39 4441957 YP_817162.1 CDS recA NC_008533.1 1732610 1733776 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1732610..1733776) Streptococcus pneumoniae D39 4442603 YP_817163.1 CDS cinA NC_008533.1 1733831 1735087 R equivalent gene in S.pneumoniae TIGR4 = SP1941; equivalent gene in S.pneumoniae R6 = spr1758; identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; competence damage-inducible protein A complement(1733831..1735087) Streptococcus pneumoniae D39 4441683 YP_817164.1 CDS SPD_1741 NC_008533.1 1735172 1736188 R equivalent gene in S.pneumoniae TIGR4 = SP1942; equivalent gene in S.pneumoniae R6 = spr1759; identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; transcriptional regulator complement(1735172..1736188) Streptococcus pneumoniae D39 4443038 YP_817165.1 CDS SPD_1742 NC_008533.1 1736196 1736714 R equivalent gene in S.pneumoniae TIGR4 = SP1943; equivalent gene in S.pneumoniae R6 = spr1760; identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1736196..1736714) Streptococcus pneumoniae D39 4442270 YP_817166.1 CDS SPD_1743 NC_008533.1 1736704 1737147 R equivalent gene in S.pneumoniae TIGR4 = SP1944; equivalent gene in S.pneumoniae R6 = spr1761; identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150; hypothetical protein complement(1736704..1737147) Streptococcus pneumoniae D39 4441056 YP_817167.1 CDS SPD_1744 NC_008533.1 1737233 1737853 R equivalent gene in S.pneumoniae TIGR4 = SP1945; equivalent gene in S.pneumoniae R6 = spr1762; hypothetical protein complement(1737233..1737853) Streptococcus pneumoniae D39 4441514 YP_817168.1 CDS SPD_1745 NC_008533.1 1738236 1739099 R equivalent gene in S.pneumoniae TIGR4 = SP1946; equivalent gene in S.pneumoniae R6 = spr1763; identified by match to protein family HMM PF01381; transcriptional regulator PlcR complement(1738236..1739099) Streptococcus pneumoniae D39 4441802 YP_817169.1 CDS SPD_1746 NC_008533.1 1739291 1739461 D equivalent gene in S.pneumoniae TIGR4 = SP1947; equivalent gene in S.pneumoniae R6 = spr1764; hypothetical protein 1739291..1739461 Streptococcus pneumoniae D39 4442512 YP_817170.1 CDS SPD_1747 NC_008533.1 1739564 1739788 D equivalent gene in S.pneumoniae TIGR4 = SP1948; equivalent gene in S.pneumoniae R6 = spr1765; hypothetical protein 1739564..1739788 Streptococcus pneumoniae D39 4442596 YP_817171.1 CDS SPD_1748 NC_008533.1 1739795 1739983 D equivalent gene in S.pneumoniae TIGR4 = SP1949; equivalent gene in S.pneumoniae R6 = spr1766; hypothetical protein 1739795..1739983 Streptococcus pneumoniae D39 4442873 YP_817172.1 CDS SPD_1749 NC_008533.1 1740099 1743089 D equivalent gene in S.pneumoniae TIGR4 = SP1950; equivalent gene in S.pneumoniae R6 = spr1767; identified by match to protein family HMM PF05147; bacteriocin formation protein 1740099..1743089 Streptococcus pneumoniae D39 4441429 YP_817173.1 CDS wrbA NC_008533.1 1743439 1744143 D equivalent gene in S.pneumoniae TIGR4 = SP1951; equivalent gene in S.pneumoniae R6 = spr1768 The crystal structure of this protein is published; identified by similarity to GB:1SQS_A; hypothetical protein 1743439..1744143 Streptococcus pneumoniae D39 4442133 YP_817174.1 CDS SPD_1751 NC_008533.1 1744124 1745053 D equivalent gene in S.pneumoniae TIGR4 = SP1952; equivalent gene in S.pneumoniae R6 = spr1769; hypothetical protein 1744124..1745053 Streptococcus pneumoniae D39 4441685 YP_817175.1 CDS SPD_1752 NC_008533.1 1745050 1747158 D equivalent gene in S.pneumoniae TIGR4 = SP1953; equivalent gene in S.pneumoniae R6 = spr1770; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; toxin secretion ABC transporter ATP-binding protein/permease 1745050..1747158 Streptococcus pneumoniae D39 4442202 YP_817176.1 CDS SPD_1753 NC_008533.1 1747182 1748921 D equivalent gene in S.pneumoniae TIGR4 = SP1954; equivalent gene in S.pneumoniae R6 = spr1771; identified by match to protein family HMM PF00082; subtilase family serine protease 1747182..1748921 Streptococcus pneumoniae D39 4441402 YP_817177.1 CDS SPD_1754 NC_008533.1 1748972 1749739 D equivalent gene in S.pneumoniae TIGR4 = SP1956; equivalent gene in S.pneumoniae R6 = spr1772; identified by match to protein family HMM PF07242; hypothetical protein 1748972..1749739 Streptococcus pneumoniae D39 4441966 YP_817178.1 CDS SPD_1755 NC_008533.1 1749741 1750373 D equivalent gene in S.pneumoniae TIGR4 = SP1957; equivalent gene in S.pneumoniae R6 = spr1773; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1749741..1750373 Streptococcus pneumoniae D39 4441471 YP_817179.1 CDS SPD_1756 NC_008533.1 1750531 1750692 D equivalent gene in S.pneumoniae TIGR4 = SP1958; equivalent gene in S.pneumoniae R6 = spr1774; hypothetical protein 1750531..1750692 Streptococcus pneumoniae D39 4441421 YP_817180.1 CDS ndk NC_008533.1 1751319 1751732 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1751319..1751732) Streptococcus pneumoniae D39 4442018 YP_817181.1 CDS rpoC NC_008533.1 1751843 1755520 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(1751843..1755520) Streptococcus pneumoniae D39 4442262 YP_817182.1 CDS rpoB NC_008533.1 1755553 1759164 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1755553..1759164) Streptococcus pneumoniae D39 4441661 YP_817183.1 CDS SPD_1761 NC_008533.1 1759848 1761179 R equivalent gene in S.pneumoniae TIGR4 = SP1963; equivalent gene in S.pneumoniae R6 = spr1778; identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; hypothetical protein complement(1759848..1761179) Streptococcus pneumoniae D39 4442902 YP_817184.1 CDS SPD_1762 NC_008533.1 1761408 1762232 R equivalent gene in S.pneumoniae TIGR4 = SP1964; equivalent gene in S.pneumoniae R6 = spr1779; identified by match to protein family HMM PF01223; DNA-entry nuclease complement(1761408..1762232) Streptococcus pneumoniae D39 4441657 YP_817185.1 CDS SPD_1763 NC_008533.1 1762271 1762477 R equivalent gene in S.pneumoniae TIGR4 = SP1965; equivalent gene in S.pneumoniae R6 = spr1780; hypothetical protein complement(1762271..1762477) Streptococcus pneumoniae D39 4442606 YP_817186.1 CDS murA-2 NC_008533.1 1762452 1763735 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1762452..1763735) Streptococcus pneumoniae D39 4442163 YP_817187.1 CDS SPD_1765 NC_008533.1 1764047 1765084 R equivalent gene in S.pneumoniae TIGR4 = SP1967; equivalent gene in S.pneumoniae R6 = spr1782; hypothetical protein complement(1764047..1765084) Streptococcus pneumoniae D39 4441572 YP_817188.1 CDS coaD NC_008533.1 1765068 1765556 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1765068..1765556) Streptococcus pneumoniae D39 4441323 YP_817189.1 CDS SPD_1767 NC_008533.1 1765546 1766085 R equivalent gene in S.pneumoniae TIGR4 = SP1969; equivalent gene in S.pneumoniae R6 = spr1784; identified by match to protein family HMM PF03602; match to protein family HMM TIGR00095; type II DNA modification methyltransferase complement(1765546..1766085) Streptococcus pneumoniae D39 4442331 YP_817190.1 CDS asnA NC_008533.1 1766150 1767142 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(1766150..1767142) Streptococcus pneumoniae D39 4441684 YP_817191.1 CDS SPD_1770 NC_008533.1 1767122 1767280 D equivalent gene in S.pneumoniae TIGR4 = SP1971; equivalent gene in S.pneumoniae R6 = spr1786; hypothetical protein 1767122..1767280 Streptococcus pneumoniae D39 4441074 YP_817192.1 CDS SPD_1769 NC_008533.1 1767254 1767961 R equivalent gene in S.pneumoniae TIGR4 = SP1972; equivalent gene in S.pneumoniae R6 = spr1787; identified by match to protein family HMM PF01027; hypothetical protein complement(1767254..1767961) Streptococcus pneumoniae D39 4442147 YP_817193.1 CDS SPD_1771 NC_008533.1 1767993 1768733 R equivalent gene in S.pneumoniae TIGR4 = SP1973; equivalent gene in S.pneumoniae R6 = spr1788; identified by match to protein family HMM PF00588; match to protein family HMM PF08032; SpoU rRNA methylase family protein complement(1767993..1768733) Streptococcus pneumoniae D39 4442057 YP_817194.1 CDS SPD_1772 NC_008533.1 1768782 1769045 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1768782..1769045 Streptococcus pneumoniae D39 4441490 YP_817195.1 CDS SPD_1773 NC_008533.1 1769123 1770049 D involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1769123..1770049 Streptococcus pneumoniae D39 4441950 YP_817196.1 CDS pflA NC_008533.1 1770124 1770918 R equivalent gene in S.pneumoniae TIGR4 = SP1976; equivalent gene in S.pneumoniae R6 = spr1791; identified by match to protein family HMM PF04055; match to protein family HMM TIGR02493; pyruvate formate-lyase activating enzyme complement(1770124..1770918) Streptococcus pneumoniae D39 4441766 YP_817197.1 CDS lysA NC_008533.1 1771044 1772294 R equivalent gene in S.pneumoniae TIGR4 = SP1978; equivalent gene in S.pneumoniae R6 = spr1792; identified by match to protein family HMM PF00278; match to protein family HMM PF02784; diaminopimelate decarboxylase complement(1771044..1772294) Streptococcus pneumoniae D39 4442592 YP_817198.1 CDS purR NC_008533.1 1772361 1773188 R equivalent gene in S.pneumoniae TIGR4 = SP1979; equivalent gene in S.pneumoniae R6 = spr1793; identified by match to protein family HMM PF00156; match to protein family HMM TIGR01743; pur operon repressor complement(1772361..1773188) Streptococcus pneumoniae D39 4442651 YP_817199.1 CDS cbf1 NC_008533.1 1773455 1774408 R equivalent gene in S.pneumoniae TIGR4 = SP1980; equivalent gene in S.pneumoniae R6 = spr1794; identified by match to protein family HMM PF01336; cmp-binding-factor 1 complement(1773455..1774408) Streptococcus pneumoniae D39 4441223 YP_817200.1 CDS SPD_1778 NC_008533.1 1774386 1775642 R equivalent gene in S.pneumoniae TIGR4 = SP1981; equivalent gene in S.pneumoniae R6 = spr1795; identified by match to protein family HMM PF02646; hypothetical protein complement(1774386..1775642) Streptococcus pneumoniae D39 4442204 YP_817201.1 CDS SPD_1779 NC_008533.1 1775644 1776306 R equivalent gene in S.pneumoniae TIGR4 = SP1982; equivalent gene in S.pneumoniae R6 = spr1796; identified by match to protein family HMM PF04263; match to protein family HMM PF04265; match to protein family HMM TIGR01378; hypothetical protein complement(1775644..1776306) Streptococcus pneumoniae D39 4441218 YP_817202.1 CDS rpe NC_008533.1 1776269 1776925 R equivalent gene in S.pneumoniae TIGR4 = SP1983; equivalent gene in S.pneumoniae R6 = spr1797; identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; ribulose-phosphate 3-epimerase complement(1776269..1776925) Streptococcus pneumoniae D39 4442906 YP_817203.1 CDS rsgA NC_008533.1 1776936 1777814 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(1776936..1777814) Streptococcus pneumoniae D39 4442623 YP_817204.1 CDS ksgA NC_008533.1 1777816 1778688 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1777816..1778688) Streptococcus pneumoniae D39 4441667 YP_817205.1 CDS SPD_1783 NC_008533.1 1778819 1779127 R equivalent gene in S.pneumoniae TIGR4 = SP1986; equivalent gene in S.pneumoniae R6 = spr1800; hypothetical protein complement(1778819..1779127) Streptococcus pneumoniae D39 4441835 YP_817206.1 CDS SPD_1784 NC_008533.1 1779120 1779761 R equivalent gene in S.pneumoniae TIGR4 = SP1987; equivalent gene in S.pneumoniae R6 = spr1801; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1779120..1779761) Streptococcus pneumoniae D39 4442997 YP_817207.1 CDS SPD_1785 NC_008533.1 1779763 1781793 R equivalent gene in S.pneumoniae TIGR4 = SP1988; equivalent gene in S.pneumoniae R6 = spr1802; identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; immunity protein complement(1779763..1781793) Streptococcus pneumoniae D39 4442278 YP_817208.1 CDS SPD_1786 NC_008533.1 1782062 1782961 R equivalent gene in S.pneumoniae TIGR4 = SP1989; equivalent gene in S.pneumoniae R6 = spr1803; identified by match to protein family HMM PF01381; transcriptional regulator PlcR complement(1782062..1782961) Streptococcus pneumoniae D39 4441145 YP_817209.1 CDS SPD_1787 NC_008533.1 1783033 1783593 R equivalent gene in S.pneumoniae TIGR4 = SP1990; equivalent gene in S.pneumoniae R6 = spr1804; identified by match to protein family HMM PF01751; match to protein family HMM TIGR00334; primase-like protein complement(1783033..1783593) Streptococcus pneumoniae D39 4441025 YP_817210.1 CDS SPD_1788 NC_008533.1 1783593 1784366 R equivalent gene in S.pneumoniae TIGR4 = SP1991; equivalent gene in S.pneumoniae R6 = spr1805; identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; TatD family hydrolase complement(1783593..1784366) Streptococcus pneumoniae D39 4441235 YP_817211.1 CDS SPD_1789 NC_008533.1 1784672 1785337 R equivalent gene in S.pneumoniae TIGR4 = SP1992; equivalent gene in S.pneumoniae R6 = spr1806; identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167; cell wall surface anchor family protein complement(1784672..1785337) Streptococcus pneumoniae D39 4442580 YP_817212.1 CDS rpmH NC_008533.1 1785600 1785734 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(1785600..1785734) Streptococcus pneumoniae D39 4441929 YP_817213.1 CDS SPD_1791 NC_008533.1 1785879 1787093 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT complement(1785879..1787093) Streptococcus pneumoniae D39 4441463 YP_817214.1 CDS SPD_1792 NC_008533.1 1787249 1787542 R equivalent gene in S.pneumoniae TIGR4 = SP1995; equivalent gene in S.pneumoniae R6 = spr1809; hypothetical protein complement(1787249..1787542) Streptococcus pneumoniae D39 4442803 YP_817215.1 CDS SPD_1793 NC_008533.1 1787704 1788156 D equivalent gene in S.pneumoniae TIGR4 = SP1996; equivalent gene in S.pneumoniae R6 = spr1810; identified by match to protein family HMM PF00582; universal stress protein family protein 1787704..1788156 Streptococcus pneumoniae D39 4442486 YP_817216.1 CDS SPD_1794 NC_008533.1 1788191 1789579 R equivalent gene in S.pneumoniae TIGR4 = SP1997; equivalent gene in S.pneumoniae R6 = spr1811; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1788191..1789579) Streptococcus pneumoniae D39 4441052 YP_817217.1 CDS SPD_1796 NC_008533.1 1789645 1790607 D equivalent gene in S.pneumoniae TIGR4 = SP1998; equivalent gene in S.pneumoniae R6 = spr1812; identified by match to protein family HMM PF00710; L-asparaginase 1789645..1790607 Streptococcus pneumoniae D39 4442855 YP_817218.1 CDS SPD_1795 NC_008533.1 1790604 1790732 R hypothetical protein complement(1790604..1790732) Streptococcus pneumoniae D39 4442541 YP_817219.1 CDS ccpA NC_008533.1 1790859 1791869 R equivalent gene in S.pneumoniae TIGR4 = SP1999; equivalent gene in S.pneumoniae R6 = spr1813; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481; catabolite control protein A complement(1790859..1791869) Streptococcus pneumoniae D39 4441881 YP_817220.1 CDS SPD_1798 NC_008533.1 1792294 1792893 R equivalent gene in S.pneumoniae TIGR4 = SP2000; equivalent gene in S.pneumoniae R6 = spr1814; identified by match to protein family HMM PF00072; match to protein family HMM PF00196; DNA-binding response regulator complement(1792294..1792893) Streptococcus pneumoniae D39 4442224 YP_817221.1 CDS SPD_1799 NC_008533.1 1792895 1793992 R equivalent gene in S.pneumoniae TIGR4 = SP2001; equivalent gene in S.pneumoniae R6 = spr1815; identified by match to protein family HMM PF02518; match to protein family HMM PF07730; sensor histidine kinase complement(1792895..1793992) Streptococcus pneumoniae D39 4441279 YP_817222.1 CDS SPD_1800 NC_008533.1 1793992 1794729 R equivalent gene in S.pneumoniae TIGR4 = SP2002; equivalent gene in S.pneumoniae R6 = spr1816; identified by match to protein family HMM PF01061; hypothetical protein complement(1793992..1794729) Streptococcus pneumoniae D39 4442968 YP_817223.1 CDS SPD_1801 NC_008533.1 1794731 1795615 R equivalent gene in S.pneumoniae R6 = spr1817; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1794731..1795615) Streptococcus pneumoniae D39 4441143 YP_817224.1 CDS SPD_1802 NC_008533.1 1795602 1795796 R hypothetical protein complement(1795602..1795796) Streptococcus pneumoniae D39 4442832 YP_817225.1 CDS SPD_1803 NC_008533.1 1795793 1795972 R equivalent gene in S.pneumoniae R6 = spr1818; hypothetical protein complement(1795793..1795972) Streptococcus pneumoniae D39 4441157 YP_817226.1 CDS comX2 NC_008533.1 1802678 1803157 R equivalent gene in S.pneumoniae TIGR4 = SP0014; equivalent gene in S.pneumoniae R6 = spr0013; transcriptional regulator ComX2 complement(1802678..1803157) Streptococcus pneumoniae D39 4442416 YP_817227.1 CDS nusG NC_008533.1 1803279 1803815 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(1803279..1803815) Streptococcus pneumoniae D39 4441437 YP_817228.1 CDS secE NC_008533.1 1803870 1804046 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1803870..1804046) Streptococcus pneumoniae D39 4442146 YP_817229.1 CDS pbp2A NC_008533.1 1804261 1806456 R equivalent gene in S.pneumoniae TIGR4 = SP2010; equivalent gene in S.pneumoniae R6 = spr1823; identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 2A complement(1804261..1806456) Streptococcus pneumoniae D39 4441503 YP_817230.1 CDS SPD_1822 NC_008533.1 1806543 1807418 D equivalent gene in S.pneumoniae TIGR4 = SP2011; equivalent gene in S.pneumoniae R6 = spr1824; identified by match to protein family HMM PF00849; ribosomal large subunit pseudouridine synthase, RluD subfamily protein 1806543..1807418 Streptococcus pneumoniae D39 4442265 YP_817231.1 CDS gap NC_008533.1 1807486 1808493 R equivalent gene in S.pneumoniae TIGR4 = SP2012; equivalent gene in S.pneumoniae R6 = spr1825; identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase complement(1807486..1808493) Streptococcus pneumoniae D39 4442561 YP_817232.1 CDS SPD_1824 NC_008533.1 1808670 1809632 R equivalent gene in S.pneumoniae TIGR4 = SP2013; equivalent gene in S.pneumoniae R6 = spr1826; identified by match to protein family HMM PF02687; hypothetical protein complement(1808670..1809632) Streptococcus pneumoniae D39 4442695 YP_817233.1 CDS nadC NC_008533.1 1810656 1811528 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase complement(1810656..1811528) Streptococcus pneumoniae D39 4442118 YP_817234.1 CDS SPD_1827 NC_008533.1 1811765 1813075 D equivalent gene in S.pneumoniae TIGR4 = SP2017; equivalent gene in S.pneumoniae R6 = spr1830; identified by match to protein family HMM PF03600; match to protein family HMM PF07158; hypothetical protein 1811765..1813075 Streptococcus pneumoniae D39 4442350 YP_817235.1 CDS SPD_1828 NC_008533.1 1813441 1813572 R equivalent gene in S.pneumoniae TIGR4 = SP2019; equivalent gene in S.pneumoniae R6 = spr1831; hypothetical protein complement(1813441..1813572) Streptococcus pneumoniae D39 4441066 YP_817236.1 CDS SPD_1829 NC_008533.1 1814095 1814823 R equivalent gene in S.pneumoniae TIGR4 = SP2020; equivalent gene in S.pneumoniae R6 = spr1832; identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator protein complement(1814095..1814823) Streptococcus pneumoniae D39 4442628 YP_817237.1 CDS SPD_1830 NC_008533.1 1814981 1816390 D equivalent gene in S.pneumoniae TIGR4 = SP2021; equivalent gene in S.pneumoniae R6 = spr1833; identified by match to protein family HMM PF00232; glycosyl hydrolase family protein 1814981..1816390 Streptococcus pneumoniae D39 4441608 YP_817238.1 CDS SPD_1831 NC_008533.1 1816408 1817703 D equivalent gene in S.pneumoniae TIGR4 = SP2022; equivalent gene in S.pneumoniae R6 = spr1834; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system transporter subunit IIC 1816408..1817703 Streptococcus pneumoniae D39 4441325 YP_817239.1 CDS SPD_1832 NC_008533.1 1817708 1818016 D equivalent gene in S.pneumoniae TIGR4 = SP2023; equivalent gene in S.pneumoniae R6 = spr1835; identified by match to protein family HMM PF02302; PTS system transporter subunit IIB 1817708..1818016 Streptococcus pneumoniae D39 4442735 YP_817240.1 CDS SPD_1833 NC_008533.1 1818013 1818321 D equivalent gene in S.pneumoniae TIGR4 = SP2024; equivalent gene in S.pneumoniae R6 = spr1836; identified by match to protein family HMM PF02255; PTS system transporter subunit IIA 1818013..1818321 Streptococcus pneumoniae D39 4442019 YP_817241.1 CDS SPD_1834 NC_008533.1 1819229 1821880 R equivalent gene in S.pneumoniae TIGR4 = SP2026; equivalent gene in S.pneumoniae R6 = spr1837; identified by match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1819229..1821880) Streptococcus pneumoniae D39 4441384 YP_817242.1 CDS SPD_1835 NC_008533.1 1822083 1822220 R hypothetical protein complement(1822083..1822220) Streptococcus pneumoniae D39 4441831 YP_817243.1 CDS SPD_1836 NC_008533.1 1822180 1822590 R equivalent gene in S.pneumoniae TIGR4 = SP2027; equivalent gene in S.pneumoniae R6 = spr1838; identified by match to protein family HMM PF02493; hypothetical protein complement(1822180..1822590) Streptococcus pneumoniae D39 4441232 YP_817244.1 CDS SPD_1837 NC_008533.1 1822592 1823020 R equivalent gene in S.pneumoniae TIGR4 = SP2028; equivalent gene in S.pneumoniae R6 = spr1839; identified by match to protein family HMM PF01451; phosphotyrosine protein phosphatase complement(1822592..1823020) Streptococcus pneumoniae D39 4442380 YP_817245.1 CDS yajC NC_008533.1 1823067 1823366 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(1823067..1823366) Streptococcus pneumoniae D39 4442816 YP_817246.1 CDS tkt NC_008533.1 1823483 1825459 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1823483..1825459) Streptococcus pneumoniae D39 4441017 YP_817247.1 CDS SPD_1840 NC_008533.1 1825573 1826664 R equivalent gene in S.pneumoniae TIGR4 = SP2031; equivalent gene in S.pneumoniae R6 = spr1842; L-ascorbate 6-phosphate lactonase complement(1825573..1826664) Streptococcus pneumoniae D39 4441692 YP_817248.1 CDS SPD_1841 NC_008533.1 1826776 1828449 R equivalent gene in S.pneumoniae TIGR4 = SP2032; equivalent gene in S.pneumoniae R6 = spr1843; identified by match to protein family HMM PF00874; BglG family transcriptional regulator complement(1826776..1828449) Streptococcus pneumoniae D39 4442697 YP_817249.1 CDS araD NC_008533.1 1828628 1829332 R catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase complement(1828628..1829332) Streptococcus pneumoniae D39 4442705 YP_817250.1 CDS SPD_1843 NC_008533.1 1829334 1830197 R L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase complement(1829334..1830197) Streptococcus pneumoniae D39 4442647 YP_817251.1 CDS ulaD NC_008533.1 1830201 1830866 R catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase complement(1830201..1830866) Streptococcus pneumoniae D39 4442586 YP_817252.1 CDS SPD_1845 NC_008533.1 1830883 1831368 R equivalent gene in S.pneumoniae TIGR4 = SP2036; equivalent gene in S.pneumoniae R6 = spr1847; identified by match to protein family HMM PF00359; PTS system transporter subunit IIA complement(1830883..1831368) Streptococcus pneumoniae D39 4441556 YP_817253.1 CDS SPD_1846 NC_008533.1 1831445 1831726 R equivalent gene in S.pneumoniae TIGR4 = SP2037; equivalent gene in S.pneumoniae R6 = spr1848; identified by match to protein family HMM PF02302; PTS system transporter subunit IIB complement(1831445..1831726) Streptococcus pneumoniae D39 4442383 YP_817254.1 CDS SPD_1847 NC_008533.1 1831749 1833206 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1831749..1833206) Streptococcus pneumoniae D39 4442327 YP_817255.1 CDS SPD_1848 NC_008533.1 1833337 1833960 R equivalent gene in S.pneumoniae TIGR4 = SP2039; equivalent gene in S.pneumoniae R6 = spr1850; hypothetical protein complement(1833337..1833960) Streptococcus pneumoniae D39 4441534 YP_817256.1 CDS SPD_1849 NC_008533.1 1834011 1834997 R equivalent gene in S.pneumoniae TIGR4 = SP2040; equivalent gene in S.pneumoniae R6 = spr1851; identified by match to protein family HMM PF01424; protein jag (SpoIIIJ-associated protein ) complement(1834011..1834997) Streptococcus pneumoniae D39 4442004 YP_817257.1 CDS SPD_1850 NC_008533.1 1835016 1835846 R equivalent gene in S.pneumoniae TIGR4 = SP2041; equivalent gene in S.pneumoniae R6 = spr1852; identified by match to protein family HMM PF02096; SpoIIIJ family protein complement(1835016..1835846) Streptococcus pneumoniae D39 4442217 YP_817258.1 CDS rnpA NC_008533.1 1835815 1836186 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(1835815..1836186) Streptococcus pneumoniae D39 4441391 YP_817259.1 CDS SPD_1852 NC_008533.1 1836203 1836334 R equivalent gene in S.pneumoniae TIGR4 = SP2043; hypothetical protein complement(1836203..1836334) Streptococcus pneumoniae D39 4442921 YP_817260.1 CDS ackA NC_008533.1 1836335 1837525 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(1836335..1837525) Streptococcus pneumoniae D39 4441549 YP_817261.1 CDS SPD_1854 NC_008533.1 1837576 1838529 R equivalent gene in S.pneumoniae TIGR4 = SP2045; equivalent gene in S.pneumoniae R6 = spr1855; hypothetical protein complement(1837576..1838529) Streptococcus pneumoniae D39 4442333 YP_817262.1 CDS SPD_1855 NC_008533.1 1838590 1838970 R equivalent gene in S.pneumoniae R6 = spr1856; hypothetical protein complement(1838590..1838970) Streptococcus pneumoniae D39 4441328 YP_817263.1 CDS SPD_1856 NC_008533.1 1839002 1839184 R equivalent gene in S.pneumoniae R6 = spr1857; hypothetical protein complement(1839002..1839184) Streptococcus pneumoniae D39 4443025 YP_817264.1 CDS SPD_1857 NC_008533.1 1839321 1839734 R equivalent gene in S.pneumoniae TIGR4 = SP2047; equivalent gene in S.pneumoniae R6 = spr1858; hypothetical protein complement(1839321..1839734) Streptococcus pneumoniae D39 4442491 YP_817265.1 CDS SPD_1858 NC_008533.1 1839712 1840173 R equivalent gene in S.pneumoniae TIGR4 = SP2048; equivalent gene in S.pneumoniae R6 = spr1859; hypothetical protein complement(1839712..1840173) Streptococcus pneumoniae D39 4442515 YP_817266.1 CDS SPD_1859 NC_008533.1 1840136 1840396 R equivalent gene in S.pneumoniae TIGR4 = SP2049; hypothetical protein complement(1840136..1840396) Streptococcus pneumoniae D39 4442844 YP_817267.1 CDS clgD NC_008533.1 1840401 1840805 R equivalent gene in S.pneumoniae TIGR4 = SP2050; equivalent gene in S.pneumoniae R6 = spr1861; identified by match to protein family HMM TIGR02532; competence protein CglD complement(1840401..1840805) Streptococcus pneumoniae D39 4442173 YP_817268.1 CDS cglC NC_008533.1 1840798 1841124 R equivalent gene in S.pneumoniae TIGR4 = SP2051; equivalent gene in S.pneumoniae R6 = spr1862; identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; competence protein CglC complement(1840798..1841124) Streptococcus pneumoniae D39 4442790 YP_817269.1 CDS cglB NC_008533.1 1841126 1841998 R equivalent gene in S.pneumoniae TIGR4 = SP2052; equivalent gene in S.pneumoniae R6 = spr1863; identified by match to protein family HMM PF00482; competence protein CglB complement(1841126..1841998) Streptococcus pneumoniae D39 4441495 YP_817270.1 CDS cglA NC_008533.1 1842090 1843031 R equivalent gene in S.pneumoniae TIGR4 = SP2053; equivalent gene in S.pneumoniae R6 = spr1864; identified by match to protein family HMM PF00437; competence protein CglA complement(1842090..1843031) Streptococcus pneumoniae D39 4442236 YP_817271.1 CDS SPD_1864 NC_008533.1 1843107 1843472 R equivalent gene in S.pneumoniae TIGR4 = SP2054; equivalent gene in S.pneumoniae R6 = spr1865; identified by match to protein family HMM PF06279; hypothetical protein complement(1843107..1843472) Streptococcus pneumoniae D39 4442789 YP_817272.1 CDS SPD_1865 NC_008533.1 1843623 1844681 R equivalent gene in S.pneumoniae TIGR4 = SP2055; equivalent gene in S.pneumoniae R6 = spr1866; identified by match to protein family HMM PF00107; zinc-containing alcohol dehydrogenase complement(1843623..1844681) Streptococcus pneumoniae D39 4441908 YP_817273.1 CDS nagA NC_008533.1 1844844 1845995 R equivalent gene in S.pneumoniae TIGR4 = SP2056; equivalent gene in S.pneumoniae R6 = spr1867; identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase complement(1844844..1845995) Streptococcus pneumoniae D39 4441513 YP_817274.1 CDS SPD_1867 NC_008533.1 1846148 1847965 R equivalent gene in S.pneumoniae TIGR4 = SP2057; equivalent gene in S.pneumoniae R6 = spr1868; identified by match to protein family HMM PF01757; hypothetical protein complement(1846148..1847965) Streptococcus pneumoniae D39 4442955 YP_817275.1 CDS tgt NC_008533.1 1848063 1849205 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(1848063..1849205) Streptococcus pneumoniae D39 4442996 YP_817276.1 CDS SPD_1869 NC_008533.1 1849335 1850192 D equivalent gene in S.pneumoniae TIGR4 = SP2059; equivalent gene in S.pneumoniae R6 = spr1870; identified by match to protein family HMM PF06161; hypothetical protein 1849335..1850192 Streptococcus pneumoniae D39 4442773 YP_817277.1 CDS SPD_1871 NC_008533.1 1851003 1851302 R equivalent gene in S.pneumoniae TIGR4 = SP2061; equivalent gene in S.pneumoniae R6 = spr1873; identified by match to protein family HMM PF06993; hypothetical protein complement(1851003..1851302) Streptococcus pneumoniae D39 4441987 YP_817278.1 CDS SPD_1873 NC_008533.1 1851734 1851847 R hypothetical protein complement(1851734..1851847) Streptococcus pneumoniae D39 4441086 YP_817279.1 CDS SPD_1874 NC_008533.1 1852057 1853199 R equivalent gene in S.pneumoniae TIGR4 = SP2063; equivalent gene in S.pneumoniae R6 = spr1875; identified by match to protein family HMM PF01476; LysM domain-containing protein complement(1852057..1853199) Streptococcus pneumoniae D39 4441670 YP_817280.1 CDS SPD_1875 NC_008533.1 1853365 1853985 R equivalent gene in S.pneumoniae TIGR4 = SP2064; equivalent gene in S.pneumoniae R6 = spr1876; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; hydrolase complement(1853365..1853985) Streptococcus pneumoniae D39 4441423 YP_817281.1 CDS SPD_1876 NC_008533.1 1853989 1855269 R equivalent gene in S.pneumoniae TIGR4 = SP2065; equivalent gene in S.pneumoniae R6 = spr1877; identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; MATE efflux family protein complement(1853989..1855269) Streptococcus pneumoniae D39 4441060 YP_817282.1 CDS thrC NC_008533.1 1855330 1856814 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(1855330..1856814) Streptococcus pneumoniae D39 4442274 YP_817283.1 CDS SPD_1878 NC_008533.1 1856890 1858167 R equivalent gene in S.pneumoniae TIGR4 = SP2067; equivalent gene in S.pneumoniae R6 = spr1879; hypothetical protein complement(1856890..1858167) Streptococcus pneumoniae D39 4441176 YP_817284.1 CDS SPD_1895 NC_008533.1 1864631 1865065 R equivalent gene in S.pneumoniae TIGR4 = SP2068; equivalent gene in S.pneumoniae R6 = spr1880; identified by match to protein family HMM PF00383; cytidine/deoxycytidylate deaminase family protein complement(1864631..1865065) Streptococcus pneumoniae D39 4441083 YP_817285.1 CDS gltX NC_008533.1 1865079 1866539 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(1865079..1866539) Streptococcus pneumoniae D39 4442022 YP_817286.1 CDS pgi NC_008533.1 1866663 1868012 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1866663..1868012) Streptococcus pneumoniae D39 4442387 YP_817287.1 CDS SPD_1898 NC_008533.1 1867999 1868178 R equivalent gene in S.pneumoniae TIGR4 = SP2071; equivalent gene in S.pneumoniae R6 = spr1883; hypothetical protein complement(1867999..1868178) Streptococcus pneumoniae D39 4442283 YP_817288.1 CDS SPD_1899 NC_008533.1 1868182 1868910 R equivalent gene in S.pneumoniae TIGR4 = SP2072; equivalent gene in S.pneumoniae R6 = spr1884; identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase, class 1 complement(1868182..1868910) Streptococcus pneumoniae D39 4443029 YP_817289.1 CDS SPD_1900 NC_008533.1 1869010 1870776 R equivalent gene in S.pneumoniae TIGR4 = SP2073; equivalent gene in S.pneumoniae R6 = spr1885; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1869010..1870776) Streptococcus pneumoniae D39 4442895 YP_817290.1 CDS SPD_1901 NC_008533.1 1871024 1871233 D equivalent gene in S.pneumoniae R6 = spr1886; transposase 1871024..1871233 Streptococcus pneumoniae D39 4441643 YP_817291.1 CDS SPD_1902 NC_008533.1 1871563 1873257 R equivalent gene in S.pneumoniae TIGR4 = SP2075; equivalent gene in S.pneumoniae R6 = spr1887; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1871563..1873257) Streptococcus pneumoniae D39 4441857 YP_817292.1 CDS mutS NC_008533.1 1873404 1875938 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(1873404..1875938) Streptococcus pneumoniae D39 4441122 YP_817293.1 CDS argR NC_008533.1 1875989 1876435 R equivalent gene in S.pneumoniae TIGR4 = SP2077; equivalent gene in S.pneumoniae R6 = spr1889; identified by match to protein family HMM PF01316; match to protein family HMM PF02863; match to protein family HMM TIGR01529; arginine repressor complement(1875989..1876435) Streptococcus pneumoniae D39 4442912 YP_817294.1 CDS argS NC_008533.1 1876583 1878274 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1876583..1878274 Streptococcus pneumoniae D39 4441042 YP_817295.1 CDS SPD_1906 NC_008533.1 1878589 1878978 R equivalent gene in S.pneumoniae TIGR4 = SP1086; equivalent gene in S.pneumoniae R6 = spr1891; identified by match to protein family HMM PF01609; IS1381, transposase OrfB complement(1878589..1878978) Streptococcus pneumoniae D39 4443008 YP_817296.1 CDS SPD_1907 NC_008533.1 1879142 1879618 D equivalent gene in S.pneumoniae TIGR4 = SP2081; equivalent gene in S.pneumoniae R6 = spr1892; identified by match to protein family HMM PF06172; hypothetical protein 1879142..1879618 Streptococcus pneumoniae D39 4442461 YP_817297.1 CDS SPD_1908 NC_008533.1 1879702 1880409 D equivalent gene in S.pneumoniae TIGR4 = SP2082; equivalent gene in S.pneumoniae R6 = spr1893; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator 1879702..1880409 Streptococcus pneumoniae D39 4441636 YP_817298.1 CDS pnpS NC_008533.1 1880410 1881741 D equivalent gene in S.pneumoniae TIGR4 = SP2083; equivalent gene in S.pneumoniae R6 = spr1894; identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor histidine kinase PnpS 1880410..1881741 Streptococcus pneumoniae D39 4441352 YP_817299.1 CDS pstS NC_008533.1 1881908 1882783 D equivalent gene in S.pneumoniae TIGR4 = SP2084; equivalent gene in S.pneumoniae R6 = spr1895; phosphate ABC transporter substrate-binding protein 1881908..1882783 Streptococcus pneumoniae D39 4442243 YP_817300.1 CDS pstC NC_008533.1 1882901 1883764 D equivalent gene in S.pneumoniae TIGR4 = SP2085; equivalent gene in S.pneumoniae R6 = spr1896; identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease 1882901..1883764 Streptococcus pneumoniae D39 4442256 YP_817301.1 CDS pstA NC_008533.1 1883757 1884572 D equivalent gene in S.pneumoniae TIGR4 = SP2086; equivalent gene in S.pneumoniae R6 = spr1897; identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease 1883757..1884572 Streptococcus pneumoniae D39 4441273 YP_817302.1 CDS pstB NC_008533.1 1884574 1885326 D ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1884574..1885326 Streptococcus pneumoniae D39 4442095 YP_817303.1 CDS phoU NC_008533.1 1885341 1885991 D equivalent gene in S.pneumoniae TIGR4 = SP2088; equivalent gene in S.pneumoniae R6 = spr1899; identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 1885341..1885991 Streptococcus pneumoniae D39 4442718 YP_817304.1 CDS SPD_1916 NC_008533.1 1886598 1887038 R equivalent gene in S.pneumoniae TIGR4 = SP2090; equivalent gene in S.pneumoniae R6 = spr1901; identified by match to protein family HMM PF01381; transcriptional regulator complement(1886598..1887038) Streptococcus pneumoniae D39 4441938 YP_817305.1 CDS SPD_1917 NC_008533.1 1887129 1887251 R hypothetical protein complement(1887129..1887251) Streptococcus pneumoniae D39 4442616 YP_817306.1 CDS gpsA NC_008533.1 1887250 1888266 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1887250..1888266 Streptococcus pneumoniae D39 4441977 YP_817307.1 CDS galU NC_008533.1 1888288 1889187 D equivalent gene in S.pneumoniae TIGR4 = SP2092; equivalent gene in S.pneumoniae R6 = spr1903; identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 1888288..1889187 Streptococcus pneumoniae D39 4441150 YP_817308.1 CDS SPD_1920 NC_008533.1 1889254 1889931 R equivalent gene in S.pneumoniae TIGR4 = SP2094; equivalent gene in S.pneumoniae R6 = spr1904; identified by match to protein family HMM PF01694; hypothetical protein complement(1889254..1889931) Streptococcus pneumoniae D39 4442145 YP_817309.1 CDS SPD_1921 NC_008533.1 1889915 1890454 R equivalent gene in S.pneumoniae TIGR4 = SP2095; equivalent gene in S.pneumoniae R6 = spr1905; identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; 5-formyltetrahydrofolate cyclo-ligase complement(1889915..1890454) Streptococcus pneumoniae D39 4441063 YP_817310.1 CDS SPD_1922 NC_008533.1 1890466 1891596 R equivalent gene in S.pneumoniae TIGR4 = SP2096; equivalent gene in S.pneumoniae R6 = spr1906; identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; peptidase, M20/M25/M40 family protein complement(1890466..1891596) Streptococcus pneumoniae D39 4441204 YP_817311.1 CDS SPD_1923 NC_008533.1 1891664 1892362 R equivalent gene in S.pneumoniae TIGR4 = SP2097; equivalent gene in S.pneumoniae R6 = spr1907; identified by match to protein family HMM PF00132; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(1891664..1892362) Streptococcus pneumoniae D39 4443052 YP_817312.1 CDS SPD_1924 NC_008533.1 1892592 1893503 R equivalent gene in S.pneumoniae TIGR4 = SP2098; equivalent gene in S.pneumoniae R6 = spr1908; identified by match to protein family HMM PF00892; hypothetical protein complement(1892592..1893503) Streptococcus pneumoniae D39 4441253 YP_817313.1 CDS pbp1B NC_008533.1 1893568 1896033 R equivalent gene in S.pneumoniae TIGR4 = SP2099; equivalent gene in S.pneumoniae R6 = spr1909; identified by match to protein family HMM PF00905; match to protein family HMM PF00912; penicillin-binding protein 1B complement(1893568..1896033) Streptococcus pneumoniae D39 4443022 YP_817314.1 CDS tyrS NC_008533.1 1896175 1897431 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1896175..1897431 Streptococcus pneumoniae D39 4442764 YP_817315.1 CDS SPD_1927 NC_008533.1 1897509 1899572 R equivalent gene in S.pneumoniae TIGR4 = SP2101; equivalent gene in S.pneumoniae R6 = spr1911; identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01512; match to protein family HMM TIGR01525; cation-transporting ATPase, E1-E2 family protein complement(1897509..1899572) Streptococcus pneumoniae D39 4441902 YP_817316.1 CDS SPD_1928 NC_008533.1 1899574 1899885 R equivalent gene in S.pneumoniae TIGR4 = SP2102; equivalent gene in S.pneumoniae R6 = spr1912; hypothetical protein complement(1899574..1899885) Streptococcus pneumoniae D39 4442723 YP_817317.1 CDS rrmA NC_008533.1 1900004 1900852 D equivalent gene in S.pneumoniae TIGR4 = SP2103; equivalent gene in S.pneumoniae R6 = spr1913; rRNA (guanine-N1-)-methyltransferase 1900004..1900852 Streptococcus pneumoniae D39 4441356 YP_817318.1 CDS SPD_1930 NC_008533.1 1901368 1901574 R equivalent gene in S.pneumoniae TIGR4 = SP2104; equivalent gene in S.pneumoniae R6 = spr1914; hypothetical protein complement(1901368..1901574) Streptococcus pneumoniae D39 4441358 YP_817319.1 CDS SPD_1931 NC_008533.1 1901651 1902223 D equivalent gene in S.pneumoniae TIGR4 = SP2105; equivalent gene in S.pneumoniae R6 = spr1915; hypothetical protein 1901651..1902223 Streptococcus pneumoniae D39 4442874 YP_817320.1 CDS malP NC_008533.1 1903268 1905526 R equivalent gene in S.pneumoniae TIGR4 = SP2106; equivalent gene in S.pneumoniae R6 = spr1916; identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; maltodextrin phosphorylase complement(1903268..1905526) Streptococcus pneumoniae D39 4441399 YP_817321.1 CDS malQ NC_008533.1 1905552 1907069 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(1905552..1907069) Streptococcus pneumoniae D39 4442130 YP_817322.1 CDS malX NC_008533.1 1907619 1908890 D equivalent gene in S.pneumoniae TIGR4 = SP2108; equivalent gene in S.pneumoniae R6 = spr1918; identified by match to protein family HMM PF01547; maltose/maltodextrin ABC transporter maltose/maltodextrin-binding protein 1907619..1908890 Streptococcus pneumoniae D39 4441847 YP_817323.1 CDS malC NC_008533.1 1909001 1910293 D equivalent gene in S.pneumoniae TIGR4 = SP2109; equivalent gene in S.pneumoniae R6 = spr1919; identified by match to protein family HMM PF00528; match to protein family HMM PF05154; maltodextrin ABC transporter permease 1909001..1910293 Streptococcus pneumoniae D39 4441625 YP_817324.1 CDS malD NC_008533.1 1910295 1911137 D equivalent gene in S.pneumoniae TIGR4 = SP2110; equivalent gene in S.pneumoniae R6 = spr1920; identified by match to protein family HMM PF00528; maltodextrin ABC transporter permease 1910295..1911137 Streptococcus pneumoniae D39 4441872 YP_817325.1 CDS malA NC_008533.1 1911390 1912190 D equivalent gene in S.pneumoniae TIGR4 = SP2111; equivalent gene in S.pneumoniae R6 = spr1921; maltodextrose utilization protein MalA 1911390..1912190 Streptococcus pneumoniae D39 4441571 YP_817326.1 CDS malR NC_008533.1 1912200 1913186 D equivalent gene in S.pneumoniae TIGR4 = SP2112; equivalent gene in S.pneumoniae R6 = spr1922; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; maltose operon transcriptional repressor 1912200..1913186 Streptococcus pneumoniae D39 4442076 YP_817327.1 CDS SPD_1939 NC_008533.1 1913253 1913474 D hypothetical protein 1913253..1913474 Streptococcus pneumoniae D39 4441561 YP_817328.1 CDS SPD_1940 NC_008533.1 1913478 1914419 R equivalent gene in S.pneumoniae TIGR4 = SP2113; equivalent gene in S.pneumoniae R6 = spr1923; identified by match to protein family HMM PF02588; hypothetical protein complement(1913478..1914419) Streptococcus pneumoniae D39 4441858 YP_817329.1 CDS aspS NC_008533.1 1914397 1916160 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1914397..1916160) Streptococcus pneumoniae D39 4442499 YP_817330.1 CDS SPD_1942 NC_008533.1 1916279 1916470 R hypothetical protein complement(1916279..1916470) Streptococcus pneumoniae D39 4441650 YP_817331.1 CDS SPD_1943 NC_008533.1 1916512 1916742 R equivalent gene in S.pneumoniae TIGR4 = SP2115; equivalent gene in S.pneumoniae R6 = spr1925; hypothetical protein complement(1916512..1916742) Streptococcus pneumoniae D39 4441092 YP_817332.1 CDS SPD_1944 NC_008533.1 1916760 1917401 R equivalent gene in S.pneumoniae TIGR4 = SP2116; equivalent gene in S.pneumoniae R6 = spr1926; identified by match to protein family HMM PF02517; hypothetical protein complement(1916760..1917401) Streptococcus pneumoniae D39 4443050 YP_817333.1 CDS SPD_1945 NC_008533.1 1917413 1918147 R equivalent gene in S.pneumoniae TIGR4 = SP2117; equivalent gene in S.pneumoniae R6 = spr1927; hypothetical protein complement(1917413..1918147) Streptococcus pneumoniae D39 4442751 YP_817334.1 CDS SPD_1946 NC_008533.1 1918150 1918347 R equivalent gene in S.pneumoniae TIGR4 = SP2118; equivalent gene in S.pneumoniae R6 = spr1928; hypothetical protein complement(1918150..1918347) Streptococcus pneumoniae D39 4441991 YP_817335.1 CDS SPD_1947 NC_008533.1 1918347 1918553 R equivalent gene in S.pneumoniae TIGR4 = SP2119; equivalent gene in S.pneumoniae R6 = spr1929; identified by match to protein family HMM PF01381; transcriptional regulator complement(1918347..1918553) Streptococcus pneumoniae D39 4441690 YP_817336.1 CDS SPD_1948 NC_008533.1 1918563 1919027 R equivalent gene in S.pneumoniae R6 = spr1930; hypothetical protein complement(1918563..1919027) Streptococcus pneumoniae D39 4442656 YP_817337.1 CDS SPD_1949 NC_008533.1 1919027 1919206 R hypothetical protein complement(1919027..1919206) Streptococcus pneumoniae D39 4443035 YP_817338.1 CDS hisS NC_008533.1 1919203 1920492 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1919203..1920492) Streptococcus pneumoniae D39 4441552 YP_817339.1 CDS SPD_1951 NC_008533.1 1920570 1921817 R equivalent gene in S.pneumoniae TIGR4 = SP2122; equivalent gene in S.pneumoniae R6 = spr1932; identified by match to protein family HMM PF07690; hypothetical protein complement(1920570..1921817) Streptococcus pneumoniae D39 4441216 YP_817340.1 CDS SPD_1952 NC_008533.1 1922007 1922858 R equivalent gene in S.pneumoniae R6 = spr1933; identified by match to protein family HMM TIGR01716; transcriptional activator Rgg/GadR/MutR family protein complement(1922007..1922858) Streptococcus pneumoniae D39 4441072 YP_817341.1 CDS SPD_1953 NC_008533.1 1922833 1922967 R equivalent gene in S.pneumoniae TIGR4 = SP2124; hypothetical protein complement(1922833..1922967) Streptococcus pneumoniae D39 4442189 YP_817342.1 CDS SPD_1954 NC_008533.1 1922982 1923323 D equivalent gene in S.pneumoniae TIGR4 = SP2125; equivalent gene in S.pneumoniae R6 = spr1934; identified by match to protein family HMM PF01883; hypothetical protein 1922982..1923323 Streptococcus pneumoniae D39 4442223 YP_817343.1 CDS SPD_1955 NC_008533.1 1923387 1923506 D hypothetical protein 1923387..1923506 Streptococcus pneumoniae D39 4442281 YP_817344.1 CDS ilvD NC_008533.1 1923532 1925235 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(1923532..1925235) Streptococcus pneumoniae D39 4441270 YP_817345.1 CDS SPD_1957 NC_008533.1 1925468 1926400 R equivalent gene in S.pneumoniae TIGR4 = SP2127; equivalent gene in S.pneumoniae R6 = spr1936; identified by match to protein family HMM PF02779; match to protein family HMM PF02780; transketolase, C-terminal subunit complement(1925468..1926400) Streptococcus pneumoniae D39 4441610 YP_817346.1 CDS SPD_1958 NC_008533.1 1926397 1927254 R equivalent gene in S.pneumoniae TIGR4 = SP2128; equivalent gene in S.pneumoniae R6 = spr1937; identified by match to protein family HMM PF00456; transketolase complement(1926397..1927254) Streptococcus pneumoniae D39 4441079 YP_817347.1 CDS ulaA NC_008533.1 1927258 1928604 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1927258..1928604) Streptococcus pneumoniae D39 4443047 YP_817348.1 CDS SPD_1960 NC_008533.1 1928617 1928901 R equivalent gene in S.pneumoniae TIGR4 = SP2130; equivalent gene in S.pneumoniae R6 = spr1939; identified by match to protein family HMM PF02302; PTS system transporter subunit IIB complement(1928617..1928901) Streptococcus pneumoniae D39 4442765 YP_817349.1 CDS SPD_1961 NC_008533.1 1928905 1930935 R equivalent gene in S.pneumoniae TIGR4 = SP2131; equivalent gene in S.pneumoniae R6 = spr1940; identified by match to protein family HMM PF00359; match to protein family HMM PF00874; BglG family transcriptional regulator complement(1928905..1930935) Streptococcus pneumoniae D39 4441655 YP_817350.1 CDS SPD_1962 NC_008533.1 1931126 1932133 D equivalent gene in S.pneumoniae TIGR4 = SP2132; equivalent gene in S.pneumoniae R6 = spr1941; identified by match to protein family HMM PF01145; hypothetical protein 1931126..1932133 Streptococcus pneumoniae D39 4441838 YP_817351.1 CDS rpmF NC_008533.1 1932488 1932670 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1932488..1932670 Streptococcus pneumoniae D39 4442772 YP_817352.1 CDS rpmG NC_008533.1 1932686 1932835 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1932686..1932835 Streptococcus pneumoniae D39 4442056 YP_817353.1 CDS pcpA NC_008533.1 1933315 1935357 R equivalent gene in S.pneumoniae TIGR4 = SP2136; equivalent gene in S.pneumoniae R6 = spr1945; identified by match to protein family HMM PF01473; choline binding protein PcpA complement(1933315..1935357) Streptococcus pneumoniae D39 4441565 YP_817354.1 CDS SPD_1966 NC_008533.1 1935714 1936283 D equivalent gene in S.pneumoniae TIGR4 = SP0537; equivalent gene in S.pneumoniae R6 = spr1946; identified by match to protein family HMM PF04326; IS1381, transposase OrfA 1935714..1936283 Streptococcus pneumoniae D39 4441597 YP_817355.1 CDS SPD_1967 NC_008533.1 1936309 1936698 D equivalent gene in S.pneumoniae TIGR4 = SP1086; equivalent gene in S.pneumoniae R6 = spr1947; identified by match to protein family HMM PF01609; IS1381, transposase OrfB 1936309..1936698 Streptococcus pneumoniae D39 4441091 YP_817356.1 CDS SPD_1968 NC_008533.1 1936750 1937076 R equivalent gene in S.pneumoniae TIGR4 = SP2139; equivalent gene in S.pneumoniae R6 = spr1948; hypothetical protein complement(1936750..1937076) Streptococcus pneumoniae D39 4442974 YP_817357.1 CDS SPD_1969 NC_008533.1 1937402 1939282 R equivalent gene in S.pneumoniae TIGR4 = SP2141; equivalent gene in S.pneumoniae R6 = spr1949; identified by match to protein family HMM PF00728; glycosyl hydrolase-like protein complement(1937402..1939282) Streptococcus pneumoniae D39 4441375 YP_817358.1 CDS SPD_1970 NC_008533.1 1939276 1940145 R equivalent gene in S.pneumoniae TIGR4 = SP2142; equivalent gene in S.pneumoniae R6 = spr1950; identified by match to protein family HMM PF00480; ROK family protein complement(1939276..1940145) Streptococcus pneumoniae D39 4442003 YP_817359.1 CDS SPD_1971 NC_008533.1 1940229 1942874 R equivalent gene in S.pneumoniae TIGR4 = SP2143; equivalent gene in S.pneumoniae R6 = spr1951; identified by match to protein family HMM PF01074; match to protein family HMM PF07748; hypothetical protein complement(1940229..1942874) Streptococcus pneumoniae D39 4442842 YP_817360.1 CDS SPD_1972 NC_008533.1 1942965 1944245 R equivalent gene in S.pneumoniae TIGR4 = SP2144; equivalent gene in S.pneumoniae R6 = spr1952; identified by match to protein family HMM PF06824; hypothetical protein complement(1942965..1944245) Streptococcus pneumoniae D39 4441974 YP_817361.1 CDS SPD_1973 NC_008533.1 1944416 1946500 D equivalent gene in S.pneumoniae TIGR4 = SP2145; equivalent gene in S.pneumoniae R6 = spr1953; identified by match to protein family HMM PF07971; match to protein family HMM TIGR01180; alpha-1,2-mannosidase 1944416..1946500 Streptococcus pneumoniae D39 4442782 YP_817362.1 CDS SPD_1974 NC_008533.1 1946540 1948219 R equivalent gene in S.pneumoniae TIGR4 = SP2146; equivalent gene in S.pneumoniae R6 = spr1954; identified by match to protein family HMM PF00754; hypothetical protein complement(1946540..1948219) Streptococcus pneumoniae D39 4442909 YP_817363.1 CDS argF NC_008533.1 1950271 1951287 D catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 1950271..1951287 Streptococcus pneumoniae D39 4442847 YP_817364.1 CDS arcC NC_008533.1 1951452 1952399 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1951452..1952399 Streptococcus pneumoniae D39 4441837 YP_817365.1 CDS SPD_1978 NC_008533.1 1952608 1954119 D equivalent gene in S.pneumoniae TIGR4 = SP2152; equivalent gene in S.pneumoniae R6 = spr1959; identified by match to protein family HMM PF03606; hypothetical protein 1952608..1954119 Streptococcus pneumoniae D39 4442694 YP_817366.1 CDS SPD_1979 NC_008533.1 1954141 1955472 D equivalent gene in S.pneumoniae TIGR4 = SP2153; equivalent gene in S.pneumoniae R6 = spr1960; identified by match to protein family HMM PF01546; match to protein family HMM TIGR01887; hypothetical protein 1954141..1955472 Streptococcus pneumoniae D39 4442560 YP_817367.1 CDS SPD_1981 NC_008533.1 1955877 1956167 R equivalent gene in S.pneumoniae R6 = spr1961; hypothetical protein complement(1955877..1956167) Streptococcus pneumoniae D39 4441044 YP_817368.1 CDS SPD_1982 NC_008533.1 1956155 1956304 R hypothetical protein complement(1956155..1956304) Streptococcus pneumoniae D39 4442086 YP_817369.1 CDS SPD_1983 NC_008533.1 1956590 1956769 D equivalent gene in S.pneumoniae R6 = spr1214; hypothetical protein 1956590..1956769 Streptococcus pneumoniae D39 4441115 YP_817370.1 CDS SPD_1984 NC_008533.1 1956806 1957705 R equivalent gene in S.pneumoniae TIGR4 = SP2156; equivalent gene in S.pneumoniae R6 = spr1962; identified by match to protein family HMM PF01145; hypersensitive-induced reaction protein 4 complement(1956806..1957705) Streptococcus pneumoniae D39 4442458 YP_817371.1 CDS SPD_1985 NC_008533.1 1957835 1958986 R equivalent gene in S.pneumoniae TIGR4 = SP2157; equivalent gene in S.pneumoniae R6 = spr1963; identified by match to protein family HMM PF00465; iron-containing alcohol dehydrogenase complement(1957835..1958986) Streptococcus pneumoniae D39 4442871 YP_817372.1 CDS fucI NC_008533.1 1959132 1960898 R catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase complement(1959132..1960898) Streptococcus pneumoniae D39 4442576 YP_817373.1 CDS SPD_1987 NC_008533.1 1960955 1964071 R equivalent gene in S.pneumoniae TIGR4 = SP2159; equivalent gene in S.pneumoniae R6 = spr1965; identified by match to protein family HMM PF00754; fucolectin-like protein complement(1960955..1964071) Streptococcus pneumoniae D39 4442901 YP_817374.1 CDS SPD_1988 NC_008533.1 1964081 1966375 R equivalent gene in S.pneumoniae TIGR4 = SP2160; equivalent gene in S.pneumoniae R6 = spr1966; hypothetical protein complement(1964081..1966375) Streptococcus pneumoniae D39 4441810 YP_817375.1 CDS SPD_1989 NC_008533.1 1966434 1967234 R equivalent gene in S.pneumoniae TIGR4 = SP2161; equivalent gene in S.pneumoniae R6 = spr1967; identified by match to protein family HMM PF03613; PTS system transporter subunit IID complement(1966434..1967234) Streptococcus pneumoniae D39 4442508 YP_817376.1 CDS SPD_1990 NC_008533.1 1967231 1968004 R equivalent gene in S.pneumoniae TIGR4 = SP2162; equivalent gene in S.pneumoniae R6 = spr1968; identified by match to protein family HMM PF03609; PTS system transporter subunit IIC complement(1967231..1968004) Streptococcus pneumoniae D39 4442924 YP_817377.1 CDS SPD_1991 NC_008533.1 1968029 1968499 R equivalent gene in S.pneumoniae TIGR4 = SP2163; equivalent gene in S.pneumoniae R6 = spr1969; identified by match to protein family HMM PF03830; PTS system transporter subunit IIB complement(1968029..1968499) Streptococcus pneumoniae D39 4441400 YP_817378.1 CDS SPD_1992 NC_008533.1 1968490 1968933 R equivalent gene in S.pneumoniae TIGR4 = SP2164; equivalent gene in S.pneumoniae R6 = spr1970; identified by match to protein family HMM PF03610; PTS system transporter subunit IIA complement(1968490..1968933) Streptococcus pneumoniae D39 4441820 YP_817379.1 CDS fucU NC_008533.1 1968914 1969354 R equivalent gene in S.pneumoniae TIGR4 = SP2165; equivalent gene in S.pneumoniae R6 = spr1971; identified by match to protein family HMM PF05025; RbsD/FucU transport protein family protein complement(1968914..1969354) Streptococcus pneumoniae D39 4442216 YP_817380.1 CDS fucA NC_008533.1 1969366 1970004 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(1969366..1970004) Streptococcus pneumoniae D39 4442280 YP_817381.1 CDS fucK NC_008533.1 1970119 1971522 R equivalent gene in S.pneumoniae TIGR4 = SP2167; equivalent gene in S.pneumoniae R6 = spr1973; identified by match to protein family HMM PF00370; match to protein family HMM PF02782; L-fuculose kinase complement(1970119..1971522) Streptococcus pneumoniae D39 4443055 YP_817382.1 CDS SPD_1996 NC_008533.1 1971698 1972471 D equivalent gene in S.pneumoniae TIGR4 = SP2168; equivalent gene in S.pneumoniae R6 = spr1974; identified by match to protein family HMM PF00455; match to protein family HMM PF08220; fucose operon repressor 1971698..1972471 Streptococcus pneumoniae D39 4442372 YP_817383.1 CDS adcA NC_008533.1 1973600 1975105 R equivalent gene in S.pneumoniae TIGR4 = SP2169; equivalent gene in S.pneumoniae R6 = spr1975; identified by match to protein family HMM PF01297; zinc ABC transporter zinc-binding lipoprotein complement(1973600..1975105) Streptococcus pneumoniae D39 4442769 YP_817384.1 CDS adcB NC_008533.1 1975115 1975921 R equivalent gene in S.pneumoniae TIGR4 = SP2170; equivalent gene in S.pneumoniae R6 = spr1976; identified by match to protein family HMM PF00950; zinc ABC transporter permease complement(1975115..1975921) Streptococcus pneumoniae D39 4443031 YP_817385.1 CDS adcC NC_008533.1 1975914 1976618 R equivalent gene in S.pneumoniae TIGR4 = SP2171; equivalent gene in S.pneumoniae R6 = spr1977; identified by match to protein family HMM PF00005; zinc ABC transporter ATP-binding protein complement(1975914..1976618) Streptococcus pneumoniae D39 4441522 YP_817386.1 CDS adcR NC_008533.1 1976618 1977058 R equivalent gene in S.pneumoniae TIGR4 = SP2172; equivalent gene in S.pneumoniae R6 = spr1978; identified by match to protein family HMM PF01022; match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF01978; adc operon repressor AdcR complement(1976618..1977058) Streptococcus pneumoniae D39 4441424 YP_817387.1 CDS SPD_2001 NC_008533.1 1977043 1977180 D hypothetical protein 1977043..1977180 Streptococcus pneumoniae D39 4442879 YP_817388.1 CDS dltD NC_008533.1 1977213 1978481 R equivalent gene in S.pneumoniae TIGR4 = SP2173; equivalent gene in S.pneumoniae R6 = spr1979; identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918; undecaprenol-phosphate-poly(glycerophosphate subunit) D-alanine transfer protein complement(1977213..1978481) Streptococcus pneumoniae D39 4441343 YP_817389.1 CDS dltC NC_008533.1 1978474 1978713 R D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 complement(1978474..1978713) Streptococcus pneumoniae D39 4442205 YP_817390.1 CDS dltB NC_008533.1 1978727 1979971 R equivalent gene in S.pneumoniae TIGR4 = SP2175; equivalent gene in S.pneumoniae R6 = spr1981; identified by match to protein family HMM PF03062; protein DltB complement(1978727..1979971) Streptococcus pneumoniae D39 4441284 YP_817391.1 CDS dltA NC_008533.1 1979968 1981518 R transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 complement(1979968..1981518) Streptococcus pneumoniae D39 4442941 YP_817392.1 CDS SPD_2006 NC_008533.1 1981539 1981670 R equivalent gene in S.pneumoniae TIGR4 = SP2177; hypothetical protein complement(1981539..1981670) Streptococcus pneumoniae D39 4442763 YP_817393.1 CDS SPD_2007 NC_008533.1 1981984 1983162 R equivalent gene in S.pneumoniae TIGR4 = SP2180; equivalent gene in S.pneumoniae R6 = spr1983; identified by match to protein family HMM PF07690; transporter major facilitator family protein complement(1981984..1983162) Streptococcus pneumoniae D39 4441874 YP_817394.1 CDS SPD_2009 NC_008533.1 1986006 1986593 D equivalent gene in S.pneumoniae TIGR4 = SP2182; equivalent gene in S.pneumoniae R6 = spr1986; hypothetical protein 1986006..1986593 Streptococcus pneumoniae D39 4443018 YP_817395.1 CDS SPD_2010 NC_008533.1 1986680 1986826 R equivalent gene in S.pneumoniae TIGR4 = SP2183; equivalent gene in S.pneumoniae R6 = spr1987; hypothetical protein complement(1986680..1986826) Streptococcus pneumoniae D39 4441438 YP_817396.1 CDS glpF NC_008533.1 1987074 1987778 R equivalent gene in S.pneumoniae TIGR4 = SP2184; equivalent gene in S.pneumoniae R6 = spr1988; identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein complement(1987074..1987778) Streptococcus pneumoniae D39 4442597 YP_817397.1 CDS glpO NC_008533.1 1987848 1989674 R equivalent gene in S.pneumoniae TIGR4 = SP2185; equivalent gene in S.pneumoniae R6 = spr1990; identified by match to protein family HMM PF01266; alpha-glycerophosphate oxidase complement(1987848..1989674) Streptococcus pneumoniae D39 4441519 YP_817398.1 CDS glpK NC_008533.1 1989716 1991224 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(1989716..1991224) Streptococcus pneumoniae D39 4441472 YP_817399.1 CDS SPD_2014 NC_008533.1 1991383 1992810 R equivalent gene in S.pneumoniae TIGR4 = SP2187; equivalent gene in S.pneumoniae R6 = spr1992; identified by match to protein family HMM PF05043; hypothetical protein complement(1991383..1992810) Streptococcus pneumoniae D39 4442340 YP_817400.1 CDS hslO NC_008533.1 1992975 1993847 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 1992975..1993847 Streptococcus pneumoniae D39 4441411 YP_817401.1 CDS SPD_2016 NC_008533.1 1993858 1994814 D equivalent gene in S.pneumoniae TIGR4 = SP2189; equivalent gene in S.pneumoniae R6 = spr1994; identified by match to protein family HMM PF01180; match to protein family HMM PF01207; match to protein family HMM TIGR00737; TIM-barrel protein, nifR3 family protein 1993858..1994814 Streptococcus pneumoniae D39 4442932 YP_817402.1 CDS cbpA NC_008533.1 1995044 1997149 R equivalent gene in S.pneumoniae R6 = spr1995 This gene is also called SpsA, pspC (pneumococcal surface protein C)and Hic; identified by match to protein family HMM PF01473; match to protein family HMM PF04650; match to protein family HMM PF05062; match to protein family HMM TIGR01168; choline binding protein A complement(1995044..1997149) Streptococcus pneumoniae D39 4441159 YP_817403.1 CDS SPD_2018 NC_008533.1 1997228 1997755 R equivalent gene in S.pneumoniae TIGR4 = SP2191; equivalent gene in S.pneumoniae R6 = spr1996; identified by match to protein family HMM PF04140; hypothetical protein complement(1997228..1997755) Streptococcus pneumoniae D39 4442396 YP_817404.1 CDS SPD_2019 NC_008533.1 1997838 1999169 R equivalent gene in S.pneumoniae TIGR4 = SP2192; equivalent gene in S.pneumoniae R6 = spr1997; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase complement(1997838..1999169) Streptococcus pneumoniae D39 4442259 YP_817405.1 CDS SPD_2020 NC_008533.1 1999166 1999819 R equivalent gene in S.pneumoniae TIGR4 = SP2193; equivalent gene in S.pneumoniae R6 = spr1998; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator complement(1999166..1999819) Streptococcus pneumoniae D39 4442588 YP_817406.1 CDS SPD_2021 NC_008533.1 2000108 2000242 R hypothetical protein complement(2000108..2000242) Streptococcus pneumoniae D39 4441175 YP_817407.1 CDS SPD_2022 NC_008533.1 2000461 2002893 R equivalent gene in S.pneumoniae TIGR4 = SP2194; equivalent gene in S.pneumoniae R6 = spr2000; identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease, ATP-binding subunit complement(2000461..2002893) Streptococcus pneumoniae D39 4442525 YP_817408.1 CDS ctsR NC_008533.1 2002895 2003353 R equivalent gene in S.pneumoniae TIGR4 = SP2195; equivalent gene in S.pneumoniae R6 = spr2001; identified by match to protein family HMM PF05848; CtsR family transcriptional regulator complement(2002895..2003353) Streptococcus pneumoniae D39 4441662 YP_817409.1 CDS SPD_2024 NC_008533.1 2003472 2004200 R equivalent gene in S.pneumoniae TIGR4 = SP2196; equivalent gene in S.pneumoniae R6 = spr2002; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(2003472..2004200) Streptococcus pneumoniae D39 4441986 YP_817410.1 CDS SPD_2025 NC_008533.1 2004200 2005207 R equivalent gene in S.pneumoniae TIGR4 = SP2197; equivalent gene in S.pneumoniae R6 = spr2003; ABC transporter substrate-binding protein complement(2004200..2005207) Streptococcus pneumoniae D39 4441146 YP_817411.1 CDS SPD_2026 NC_008533.1 2005245 2005961 R equivalent gene in S.pneumoniae TIGR4 = SP2198; equivalent gene in S.pneumoniae R6 = spr2004; identified by match to protein family HMM PF00528; ABC transporter permease complement(2005245..2005961) Streptococcus pneumoniae D39 4441059 YP_817412.1 CDS SPD_2027 NC_008533.1 2005966 2006256 R equivalent gene in S.pneumoniae TIGR4 = SP2199; equivalent gene in S.pneumoniae R6 = spr2005; hypothetical protein complement(2005966..2006256) Streptococcus pneumoniae D39 4442114 YP_817413.1 CDS cbpD NC_008533.1 2006512 2007858 R equivalent gene in S.pneumoniae TIGR4 = SP2201; equivalent gene in S.pneumoniae R6 = spr2006; identified by match to protein family HMM PF01473; match to protein family HMM PF05257; choline binding protein D complement(2006512..2007858) Streptococcus pneumoniae D39 4442443 YP_817414.1 CDS SPD_2029 NC_008533.1 2007947 2008213 R equivalent gene in S.pneumoniae TIGR4 = SP2202; equivalent gene in S.pneumoniae R6 = spr2007; identified by match to protein family HMM PF06257; hypothetical protein complement(2007947..2008213) Streptococcus pneumoniae D39 4441198 YP_817415.1 CDS dnaB NC_008533.1 2008215 2009567 R unwinds double stranded DNA; replicative DNA helicase complement(2008215..2009567) Streptococcus pneumoniae D39 4441658 YP_817416.1 CDS rplI NC_008533.1 2009611 2010063 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(2009611..2010063) Streptococcus pneumoniae D39 4441077 YP_817417.1 CDS SPD_2032 NC_008533.1 2010060 2012033 R equivalent gene in S.pneumoniae TIGR4 = SP2205; equivalent gene in S.pneumoniae R6 = spr2010; identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein complement(2010060..2012033) Streptococcus pneumoniae D39 4442059 YP_817418.1 CDS yfiA NC_008533.1 2012169 2012717 R equivalent gene in S.pneumoniae TIGR4 = SP2206; equivalent gene in S.pneumoniae R6 = spr2011; identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741; ribosomal subunit interface protein complement(2012169..2012717) Streptococcus pneumoniae D39 4442067 YP_817419.1 CDS SPD_2034 NC_008533.1 2012797 2013459 R equivalent gene in S.pneumoniae TIGR4 = SP2207; equivalent gene in S.pneumoniae R6 = spr2012; competence protein ComF complement(2012797..2013459) Streptococcus pneumoniae D39 4441105 YP_817420.1 CDS SPD_2035 NC_008533.1 2013456 2014754 R equivalent gene in S.pneumoniae TIGR4 = SP2208; equivalent gene in S.pneumoniae R6 = spr2013; identified by match to protein family HMM PF00271; match to protein family HMM PF04851; helicase complement(2013456..2014754) Streptococcus pneumoniae D39 4442287 YP_817421.1 CDS SPD_2036 NC_008533.1 2014810 2015445 D equivalent gene in S.pneumoniae TIGR4 = SP2209; equivalent gene in S.pneumoniae R6 = spr2014; identified by match to protein family HMM PF01205; match to protein family HMM TIGR00257; hypothetical protein 2014810..2015445 Streptococcus pneumoniae D39 4441286 YP_817422.1 CDS cysK NC_008533.1 2015730 2016650 D equivalent gene in S.pneumoniae TIGR4 = SP2210; equivalent gene in S.pneumoniae R6 = spr2015; identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; cysteine synthase A 2015730..2016650 Streptococcus pneumoniae D39 4441595 YP_817423.1 CDS SPD_2038 NC_008533.1 2016847 2017116 R equivalent gene in S.pneumoniae R6 = spr2016; hypothetical protein complement(2016847..2017116) Streptococcus pneumoniae D39 4442712 YP_817424.1 CDS tsf NC_008533.1 2018234 2019274 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(2018234..2019274) Streptococcus pneumoniae D39 4442533 YP_817425.1 CDS rpsB NC_008533.1 2019340 2020119 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(2019340..2020119) Streptococcus pneumoniae D39 4442366 YP_817426.1 CDS SPD_2043 NC_008533.1 2020343 2021521 R equivalent gene in S.pneumoniae TIGR4 = SP2216; equivalent gene in S.pneumoniae R6 = spr2021; identified by match to protein family HMM PF05257; hypothetical protein complement(2020343..2021521) Streptococcus pneumoniae D39 4441219 YP_817427.1 CDS SPD_2044 NC_008533.1 2021615 2022109 R equivalent gene in S.pneumoniae TIGR4 = SP2217; equivalent gene in S.pneumoniae R6 = spr2022; identified by match to protein family HMM PF04093; rod shpae-determining protein MreD complement(2021615..2022109) Streptococcus pneumoniae D39 4441303 YP_817428.1 CDS mreC NC_008533.1 2022109 2022927 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(2022109..2022927) Streptococcus pneumoniae D39 4443036 YP_817429.1 CDS SPD_2046 NC_008533.1 2022986 2023780 R equivalent gene in S.pneumoniae TIGR4 = SP2219; equivalent gene in S.pneumoniae R6 = spr2024; identified by match to protein family HMM PF02361; cobalt ABC transporter permease complement(2022986..2023780) Streptococcus pneumoniae D39 4441772 YP_817430.1 CDS cbiO NC_008533.1 2023773 2024612 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2023773..2024612) Streptococcus pneumoniae D39 4441932 YP_817431.1 CDS cbiO NC_008533.1 2024597 2025424 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2024597..2025424) Streptococcus pneumoniae D39 4442439 YP_817432.1 CDS pgsA NC_008533.1 2025421 2025966 R equivalent gene in S.pneumoniae TIGR4 = SP2222; equivalent gene in S.pneumoniae R6 = spr2027; identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2025421..2025966) Streptococcus pneumoniae D39 4442119 YP_817433.1 CDS SPD_2050 NC_008533.1 2025977 2026798 R equivalent gene in S.pneumoniae TIGR4 = SP2223; equivalent gene in S.pneumoniae R6 = spr2028; hypothetical protein complement(2025977..2026798) Streptococcus pneumoniae D39 4442403 YP_817434.1 CDS SPD_2051 NC_008533.1 2026840 2028123 R equivalent gene in S.pneumoniae TIGR4 = SP2224; equivalent gene in S.pneumoniae R6 = spr2029; identified by match to protein family HMM PF00675; match to protein family HMM PF05193; peptidase, M16 family protein complement(2026840..2028123) Streptococcus pneumoniae D39 4441412 YP_817435.1 CDS SPD_2052 NC_008533.1 2028120 2029370 R equivalent gene in S.pneumoniae TIGR4 = SP2225; equivalent gene in S.pneumoniae R6 = spr2030; identified by match to protein family HMM PF05193; hypothetical protein complement(2028120..2029370) Streptococcus pneumoniae D39 4441295 YP_817436.1 CDS SPD_2053 NC_008533.1 2029529 2029897 D equivalent gene in S.pneumoniae TIGR4 = SP2226; equivalent gene in S.pneumoniae R6 = spr2031; hypothetical protein 2029529..2029897 Streptococcus pneumoniae D39 4441614 YP_817437.1 CDS recF NC_008533.1 2029900 2030997 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2029900..2030997 Streptococcus pneumoniae D39 4441043 YP_817438.1 CDS guaB NC_008533.1 2031048 2032526 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2031048..2032526) Streptococcus pneumoniae D39 4441407 YP_817439.1 CDS trpS NC_008533.1 2032678 2033703 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II complement(2032678..2033703) Streptococcus pneumoniae D39 4442206 YP_817440.1 CDS SPD_2057 NC_008533.1 2033909 2035531 D equivalent gene in S.pneumoniae TIGR4 = SP2230; equivalent gene in S.pneumoniae R6 = spr2035; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 2033909..2035531 Streptococcus pneumoniae D39 4441094 YP_817441.1 CDS SPD_2058 NC_008533.1 2035593 2038145 D equivalent gene in S.pneumoniae TIGR4 = SP2231; equivalent gene in S.pneumoniae R6 = spr2036; ABC transporter permease 2035593..2038145 Streptococcus pneumoniae D39 4442170 YP_817442.1 CDS SPD_2060 NC_008533.1 2039957 2040499 D equivalent gene in S.pneumoniae TIGR4 = SP2234; equivalent gene in S.pneumoniae R6 = spr2040; identified by match to protein family HMM PF00440; transcriptional regulator, TetR family protein 2039957..2040499 Streptococcus pneumoniae D39 4441221 YP_817443.1 CDS comE NC_008533.1 2040742 2041494 R equivalent gene in S.pneumoniae TIGR4 = SP2235; equivalent gene in S.pneumoniae R6 = spr2041; identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator complement(2040742..2041494) Streptococcus pneumoniae D39 4441307 YP_817444.1 CDS comD NC_008533.1 2041491 2042816 R equivalent gene in S.pneumoniae TIGR4 = SP2236; equivalent gene in S.pneumoniae R6 = spr2042; identified by match to protein family HMM PF02518; sensor histidine kinase ComD complement(2041491..2042816) Streptococcus pneumoniae D39 4442986 YP_817445.1 CDS comC1 NC_008533.1 2042837 2042962 R equivalent gene in S.pneumoniae R6 = spr2043; identified by match to protein family HMM PF03047; competence-stimulating peptide type 1 complement(2042837..2042962) Streptococcus pneumoniae D39 4441955 YP_817446.1 CDS SPD_2067 NC_008533.1 2043244 2043723 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(2043244..2043723) Streptococcus pneumoniae D39 4442870 YP_817447.1 CDS SPD_2068 NC_008533.1 2043906 2045087 D equivalent gene in S.pneumoniae TIGR4 = SP2239; equivalent gene in S.pneumoniae R6 = spr2045; identified by match to protein family HMM PF00089; serine protease 2043906..2045087 Streptococcus pneumoniae D39 4442324 YP_817448.1 CDS SPD_2069 NC_008533.1 2045145 2045903 D equivalent gene in S.pneumoniae TIGR4 = SP2240; equivalent gene in S.pneumoniae R6 = spr2046; identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; SpoJ protein 2045145..2045903 Streptococcus pneumoniae D39 4442402 SPD_0015 tRNA SPD_0015 NC_008533.1 14827 14898 D tRNA-Glu 14827..14898 Streptococcus pneumoniae D39 4441726 SPD_0017 tRNA SPD_0017 NC_008533.1 16748 16820 D tRNA-Ala 16748..16820 Streptococcus pneumoniae D39 4441798 SPD_0020 tRNA SPD_0020 NC_008533.1 20044 20117 D tRNA-Asn 20044..20117 Streptococcus pneumoniae D39 4441750 SPD_0755 tRNA SPD_0755 NC_008533.1 766945 767025 D tRNA-Tyr 766945..767025 Streptococcus pneumoniae D39 4441742 SPD_0756 tRNA SPD_0756 NC_008533.1 767035 767106 D tRNA-Gln 767035..767106 Streptococcus pneumoniae D39 4441788 SPD_0770 tRNA SPD_0770 NC_008533.1 781668 781755 R tRNA-Ser complement(781668..781755) Streptococcus pneumoniae D39 4441746 SPD_0899 tRNA SPD_0899 NC_008533.1 912395 912467 D tRNA-Thr 912395..912467 Streptococcus pneumoniae D39 4441752 SPD_1106 tRNA SPD_1106 NC_008533.1 1139077 1139148 R tRNA-Arg complement(1139077..1139148) Streptococcus pneumoniae D39 4441782 SPD_1147 tRNA SPD_1147 NC_008533.1 1180908 1180979 R tRNA-Arg complement(1180908..1180979) Streptococcus pneumoniae D39 4441759 SPD_1410 tRNA SPD_1410 NC_008533.1 1429525 1429610 R tRNA-Leu complement(1429525..1429610) Streptococcus pneumoniae D39 4441757 SPD_1581 tRNA SPD_1581 NC_008533.1 1598070 1598142 D tRNA-Lys 1598070..1598142 Streptococcus pneumoniae D39 4441727 SPD_1682 tRNA SPD_1682 NC_008533.1 1698314 1698401 R tRNA-Ser complement(1698314..1698401) Streptococcus pneumoniae D39 4441792 SPD_1683 tRNA SPD_1683 NC_008533.1 1698408 1698481 R tRNA-Ile complement(1698408..1698481) Streptococcus pneumoniae D39 4441747 SPD_1684 tRNA SPD_1684 NC_008533.1 1698517 1698587 R tRNA-Gly complement(1698517..1698587) Streptococcus pneumoniae D39 4441758 SPD_1685 tRNA SPD_1685 NC_008533.1 1698607 1698679 R tRNA-Phe complement(1698607..1698679) Streptococcus pneumoniae D39 4441786 SPD_1686 tRNA SPD_1686 NC_008533.1 1698683 1698756 R tRNA-Met complement(1698683..1698756) Streptococcus pneumoniae D39 4441714 SPD_1687 tRNA SPD_1687 NC_008533.1 1698770 1698859 R tRNA-Ser complement(1698770..1698859) Streptococcus pneumoniae D39 4441732 SPD_1688 tRNA SPD_1688 NC_008533.1 1698870 1698943 R tRNA-Met complement(1698870..1698943) Streptococcus pneumoniae D39 4441739 SPD_1689 tRNA SPD_1689 NC_008533.1 1698957 1699030 R tRNA-Met complement(1698957..1699030) Streptococcus pneumoniae D39 4441785 SPD_1690 tRNA SPD_1690 NC_008533.1 1699036 1699109 R tRNA-Pro complement(1699036..1699109) Streptococcus pneumoniae D39 4441753 SPD_1691 tRNA SPD_1691 NC_008533.1 1699125 1699198 R tRNA-Arg complement(1699125..1699198) Streptococcus pneumoniae D39 4441794 SPD_1692 tRNA SPD_1692 NC_008533.1 1699208 1699293 R tRNA-Leu complement(1699208..1699293) Streptococcus pneumoniae D39 4441737 SPD_1693 tRNA SPD_1693 NC_008533.1 1699301 1699372 R tRNA-Gly complement(1699301..1699372) Streptococcus pneumoniae D39 4441733 SPD_1694 tRNA SPD_1694 NC_008533.1 1699395 1699467 R tRNA-Thr complement(1699395..1699467) Streptococcus pneumoniae D39 4441754 SPD_1695 tRNA SPD_1695 NC_008533.1 1699486 1699567 R tRNA-Leu complement(1699486..1699567) Streptococcus pneumoniae D39 4441748 SPD_1696 tRNA SPD_1696 NC_008533.1 1699573 1699645 R tRNA-Lys complement(1699573..1699645) Streptococcus pneumoniae D39 4441741 SPD_1697 tRNA SPD_1697 NC_008533.1 1699670 1699742 R tRNA-Asp complement(1699670..1699742) Streptococcus pneumoniae D39 4441728 SPD_1698 tRNA SPD_1698 NC_008533.1 1699745 1699817 R tRNA-Val complement(1699745..1699817) Streptococcus pneumoniae D39 4441799 SPD_1701 tRNA SPD_1701 NC_008533.1 1703040 1703112 R tRNA-Ala complement(1703040..1703112) Streptococcus pneumoniae D39 4441797 SPD_1703 tRNA SPD_1703 NC_008533.1 1704962 1705033 R tRNA-Glu complement(1704962..1705033) Streptococcus pneumoniae D39 4441781 SPD_1760 tRNA SPD_1760 NC_008533.1 1759580 1759650 D tRNA-Cys 1759580..1759650 Streptococcus pneumoniae D39 4441723 SPD_1804 tRNA SPD_1804 NC_008533.1 1796587 1796660 R tRNA-Pro complement(1796587..1796660) Streptococcus pneumoniae D39 4441783 SPD_1805 tRNA SPD_1805 NC_008533.1 1796676 1796749 R tRNA-Arg complement(1796676..1796749) Streptococcus pneumoniae D39 4441791 SPD_1806 tRNA SPD_1806 NC_008533.1 1796759 1796844 R tRNA-Leu complement(1796759..1796844) Streptococcus pneumoniae D39 4441744 SPD_1807 tRNA SPD_1807 NC_008533.1 1796852 1796923 R tRNA-Gly complement(1796852..1796923) Streptococcus pneumoniae D39 4441743 SPD_1808 tRNA SPD_1808 NC_008533.1 1796946 1797018 R tRNA-Thr complement(1796946..1797018) Streptococcus pneumoniae D39 4441745 SPD_1809 tRNA SPD_1809 NC_008533.1 1797037 1797118 R tRNA-Leu complement(1797037..1797118) Streptococcus pneumoniae D39 4441736 SPD_1810 tRNA SPD_1810 NC_008533.1 1797124 1797196 R tRNA-Lys complement(1797124..1797196) Streptococcus pneumoniae D39 4441780 SPD_1811 tRNA SPD_1811 NC_008533.1 1797221 1797293 R tRNA-Asp complement(1797221..1797293) Streptococcus pneumoniae D39 4441787 SPD_1812 tRNA SPD_1812 NC_008533.1 1797296 1797368 R tRNA-Val complement(1797296..1797368) Streptococcus pneumoniae D39 4441795 SPD_1815 tRNA SPD_1815 NC_008533.1 1800591 1800663 R tRNA-Ala complement(1800591..1800663) Streptococcus pneumoniae D39 4441735 SPD_1817 tRNA SPD_1817 NC_008533.1 1802513 1802584 R tRNA-Glu complement(1802513..1802584) Streptococcus pneumoniae D39 4441738 SPD_1879 tRNA SPD_1879 NC_008533.1 1858274 1858357 R tRNA-Leu complement(1858274..1858357) Streptococcus pneumoniae D39 4441731 SPD_1880 tRNA SPD_1880 NC_008533.1 1858367 1858438 R tRNA-Gln complement(1858367..1858438) Streptococcus pneumoniae D39 4441713 SPD_1881 tRNA SPD_1881 NC_008533.1 1858449 1858521 R tRNA-His complement(1858449..1858521) Streptococcus pneumoniae D39 4441730 SPD_1882 tRNA SPD_1882 NC_008533.1 1858536 1858606 R tRNA-Trp complement(1858536..1858606) Streptococcus pneumoniae D39 4441784 SPD_1883 tRNA SPD_1883 NC_008533.1 1858611 1858691 R tRNA-Tyr complement(1858611..1858691) Streptococcus pneumoniae D39 4441729 SPD_1884 tRNA SPD_1884 NC_008533.1 1858704 1858776 R tRNA-Phe complement(1858704..1858776) Streptococcus pneumoniae D39 4441751 SPD_1885 tRNA SPD_1885 NC_008533.1 1858780 1858853 R tRNA-Met complement(1858780..1858853) Streptococcus pneumoniae D39 4441725 SPD_1886 tRNA SPD_1886 NC_008533.1 1858864 1858953 R tRNA-Ser complement(1858864..1858953) Streptococcus pneumoniae D39 4441793 SPD_1887 tRNA SPD_1887 NC_008533.1 1859037 1859110 R tRNA-Ile complement(1859037..1859110) Streptococcus pneumoniae D39 4441734 SPD_1888 tRNA SPD_1888 NC_008533.1 1859145 1859215 R tRNA-Gly complement(1859145..1859215) Streptococcus pneumoniae D39 4441740 SPD_1889 tRNA SPD_1889 NC_008533.1 1859221 1859293 R tRNA-Val complement(1859221..1859293) Streptococcus pneumoniae D39 4441749 SPD_1892 tRNA SPD_1892 NC_008533.1 1862516 1862588 R tRNA-Ala complement(1862516..1862588) Streptococcus pneumoniae D39 4441755 SPD_1894 tRNA SPD_1894 NC_008533.1 1864438 1864509 R tRNA-Glu complement(1864438..1864509) Streptococcus pneumoniae D39 4441715 SPD_2061 tRNA SPD_2061 NC_008533.1 2040540 2040613 R tRNA-Asn complement(2040540..2040613) Streptococcus pneumoniae D39 4441756 SPD_2062 tRNA SPD_2062 NC_008533.1 2040619 2040690 R tRNA-Glu complement(2040619..2040690) Streptococcus pneumoniae D39 4441796 SPD_2066 tRNA SPD_2066 NC_008533.1 2043127 2043200 R tRNA-Arg complement(2043127..2043200) Streptococcus pneumoniae D39 4441724 SPD_0016 rRNA rrsA NC_008533.1 15164 16621 D 16S ribosomal RNA 15164..16621 Streptococcus pneumoniae D39 4441719 SPD_0018 rRNA rrlA NC_008533.1 16945 19846 D 23S ribosomal RNA 16945..19846 Streptococcus pneumoniae D39 4441707 SPD_0019 rRNA rrfA NC_008533.1 19923 20038 D 5S ribosomal RNA 19923..20038 Streptococcus pneumoniae D39 4441718 SPD_1699 rRNA rrfB NC_008533.1 1699822 1699937 R 5S ribosomal RNA complement(1699822..1699937) Streptococcus pneumoniae D39 4441722 SPD_1700 rRNA rrlB NC_008533.1 1700014 1702915 R 23S ribosomal RNA complement(1700014..1702915) Streptococcus pneumoniae D39 4441705 SPD_1702 rRNA rrsB NC_008533.1 1703239 1704696 R 16S ribosomal RNA complement(1703239..1704696) Streptococcus pneumoniae D39 4441716 SPD_1813 rRNA rrfC NC_008533.1 1797373 1797488 R 5S ribosomal RNA complement(1797373..1797488) Streptococcus pneumoniae D39 4441708 SPD_1814 rRNA rrlC NC_008533.1 1797565 1800466 R 23S ribosomal RNA complement(1797565..1800466) Streptococcus pneumoniae D39 4441709 SPD_1816 rRNA rrsC NC_008533.1 1800790 1802247 R 16S ribosomal RNA complement(1800790..1802247) Streptococcus pneumoniae D39 4441720 SPD_1890 rRNA rrfD NC_008533.1 1859298 1859413 R 5S ribosomal RNA complement(1859298..1859413) Streptococcus pneumoniae D39 4441717 SPD_1891 rRNA rrlD NC_008533.1 1859490 1862391 R 23S ribosomal RNA complement(1859490..1862391) Streptococcus pneumoniae D39 4441721 SPD_1893 rRNA rrsD NC_008533.1 1862715 1864172 R 16S ribosomal RNA complement(1862715..1864172) Streptococcus pneumoniae D39 4441706